TDMS Study 88124-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 02/22/00
EXPERIMENT: 88124 TEST: 04 TIME: 09:32:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: MILLER, R. CAS: 22398-80-7
------------------------------------------------------------------------------------------------------------------------------------
FINAL#2,
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 02/22/00
EXPERIMENT: 88124 TEST: 04 TIME: 09:32:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: MILLER, R. CAS: 22398-80-7
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 559 561 590 607 615 662 664 669 671 686 |
| 686 716 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.03 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 1 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 331 405 405 421 457 504 530 557 562 562 |
| 562 571 574 589 638 682 687 687 687 700 |
| 700 706 715 729 730 |
| CENSORED DEATHS |
| 700 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1MG/M3 STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 475 478 481 491 562 572 597 625 635 644 |
| 650 657 657 664 669 672 678 681 681 682 |
| 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.3MG/M3 STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 370 471 501 533 562 562 589 589 595 608 |
| 619 632 645 648 664 668 671 685 687 706 |
| 715 715 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 94.0 86.0 74.0 |
| | |
| | |
|0.03 | 100.0 100.0 100.0 98.0 92.0 90.0 86.0 72.0 70.0 49.7 |
|MG/M3 | |
| | |
|0.1MG/M3 | 100.0 100.0 100.0 100.0 100.0 94.0 92.0 86.0 72.0 58.0 |
|STOP | |
| | |
|0.3MG/M3 | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 82.0 70.0 54.0 |
|STOP | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| MG/M3 STOP STOP |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 49.7% 58.0% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.288 P=0.016 P=0.106 P=0.046 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 647.1 587.6 618.0 615.7 |
|NATURAL DEATHS (C) | (15.3) (23.4) (17.0) (18.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 710.7 659.7 684.7 679.1 |
|(STANDARD ERROR) | ( 6.6) (15.5) (10.7) (11.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 1 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 264 593 626 664 678 699 715 |
| CENSORED DEATHS |
| 517 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.03 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 426 489 514 514 533 533 533 533 548 580 |
| 589 589 617 617 630 645 645 645 645 653 |
| 657 659 671 674 674 686 686 687 687 688 |
| 688 688 700 706 715 727 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1MG/M3 STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 547 589 617 617 658 664 672 672 681 685 |
| 687 687 691 699 699 728 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.3MG/M3 STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 1 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 421 421 487 493 496 510 512 533 578 594 |
| 600 608 615 619 633 642 645 650 658 669 |
| 687 695 695 705 709 726 727 729 |
| CENSORED DEATHS |
| 197 |
| |
==================================================================================
INDIUM PHOSPHIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 98.0 98.0 98.0 96.0 91.9 85.7 |
| | |
| | |
|0.03 | 100.0 100.0 100.0 100.0 100.0 98.0 84.0 76.0 56.0 26.0 |
|MG/M3 | |
| | |
|0.1MG/M3 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 88.0 66.0 |
|STOP | |
| | |
|0.3MG/M3 | 100.0 100.0 100.0 100.0 95.9 95.9 83.7 77.6 61.2 42.9 |
|STOP | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| MG/M3 STOP STOP |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 85.7% 26.0% 66.0% 42.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.029 P<0.001 P=0.044 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 605.6 627.1 666.0 609.2 |
|NATURAL DEATHS (C) | (59.1) (12.5) (11.7) (17.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 712.5 655.2 711.5 653.8 |
|(STANDARD ERROR) | (10.8) (11.4) ( 6.1) (16.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
INDIUM PHOSPHIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.03 MG/M3 = 2
0.1MG/M3 STOP = 3
0.3MG/M3 STOP = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 2 4 3 1
|
| 2 4 2 33 11
| 4 4 1 1
95 +
| 2 2 3 34 4 1 1
| 2 2 3 4 3 11
|
90 + 2 2 33 1 1
|
| 2 2 43 43
| 2 2 3 3 11
P 85 +
E | 22 33
R | 4 4 33 1 1
C |
E 80 + 4 4 33
N |
T | 22 4 4 33 1 1
| 4 4 11
S 75 +
U | 2 2 3 3 1 1
R | 2 24 33
V |
I 70 + 2 44 2
V |
A | 3322
L | 433
65 +
| 44
| 224
|
60 + 3 4 43
|
| 22 3 3
| 2 24
55 +
| 24 2
|
|
50 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
INDIUM PHOSPHIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.03 MG/M3 = 2
0.1MG/M3 STOP = 3
0.3MG/M3 STOP = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
104 +
|
| 1 1 2 3
| 1 2 2 3 1
96 + 4 2 2 1 31
| 44 1 1
| 2 2 3 3 1 1
| 4 4 3 3 1 1
88 + 44 33 1 1
| 4 4 1 1
| 2 2 4 3 3
| 2 2 4
P 80 + 2 24 33
E | 44
R | 2 442
C | 44 33
E 72 + 224
N | 2442 3 3
T | 44 3 3
| 3
S 64 + 44
U | 22 4
R | 4 4
V | 2 2 44
I 56 + 22
V | 22 44
A | 44
L | 22
48 + 4 4
| 22
| 4 4
| 4
40 +
|
| 22
| 22
32 + 2 2
| 22
| 2 2
| 2
24 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.
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