TDMS Study 88127-03 Pathology Tables
NTP Experiment-Test: 88127-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PENTAERYTHRITOL TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:48:22
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 3524-68-3
Lock Date: 10/09/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88127-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PENTAERYTHRITOL TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (4) (1) (1) (10)
Hepatodiaphragmatic Nodule 1 (100%) 3 (75%) 1 (100%) 1 (100%) 2 (20%)
Inflammation, Chronic Active 9 (90%) 4 (40%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (10)
Ultimobranchial Cyst 1 (10%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (1) (10)
Atrophy 1 (10%)
Cyst 1 (10%) 1 (100%) 1 (10%)
Ovary (10) (1) (1) (10)
Cyst 1 (100%) 1 (100%)
Uterus (10) (10)
Hydrometra 1 (10%) 5 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88127-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PENTAERYTHRITOL TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mesenteric (10) (10)
Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Dermis, Skin, Site of Application, Fibrosis 1 (10%)
Dermis, Skin, Site of Application,
Inflammation, Chronic Active 3 (30%) 4 (40%) 9 (90%) 10 (100%)
Epidermis, Skin, Site of Application,
Degeneration 4 (40%) 5 (50%) 5 (50%) 6 (60%)
Epidermis, Skin, Site of Application,
Hyperplasia 3 (30%) 8 (80%) 8 (80%) 9 (90%)
Epidermis, Skin, Site of Application,
Inflammation, Suppurative 4 (40%)
Epidermis, Skin, Site of Application,
Necrosis 3 (30%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 8 (80%) 8 (80%) 10 (100%) 9 (90%)
Skin, Site of Application, Hyperkeratosis 4 (40%) 8 (80%) 9 (90%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation, Chronic Active 4 (40%) 7 (70%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88127-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PENTAERYTHRITOL TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88127-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PENTAERYTHRITOL TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (4) (2) (2) (2) (10)
Hepatodiaphragmatic Nodule 3 (30%) 4 (100%) 1 (50%) 2 (100%) 1 (50%) 3 (30%)
Tongue (1)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 2 (20%) 2 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10)
Inflammation, Chronic Active 1 (10%) 1 (10%)
Prostate (10) (10)
Inflammation, Chronic Active 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mesenteric (10) (10)
Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88127-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PENTAERYTHRITOL TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Dermis, Skin, Site of Application,
Inflammation, Chronic Active 1 (10%) 3 (30%) 10 (100%) 10 (100%) 9 (90%)
Epidermis, Skin, Site of Application,
Degeneration 1 (10%) 6 (60%) 7 (70%) 7 (70%) 5 (50%)
Epidermis, Skin, Site of Application,
Hyperplasia 1 (10%) 2 (20%) 7 (70%) 9 (90%) 10 (100%) 7 (70%)
Epidermis, Skin, Site of Application,
Inflammation, Suppurative 6 (60%) 3 (30%)
Epidermis, Skin, Site of Application,
Necrosis 1 (10%) 1 (10%) 5 (50%) 2 (20%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 2 (20%) 9 (90%) 9 (90%) 10 (100%) 9 (90%)
Skin, Site of Application, Degeneration 1 (10%)
Skin, Site of Application, Hyperkeratosis 2 (20%) 8 (80%) 10 (100%) 10 (100%) 10 (100%) 9 (90%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation, Chronic Active 7 (70%) 8 (80%)
Nose (10) (10)
Inflammation, Acute 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88127-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PENTAERYTHRITOL TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Nephropathy 4 (40%) 6 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
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