TDMS Study 88127-06 Pathology Tables
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
Final#2
Facility: Battelle Columbus Laboratory
Chemical CAS #: 3524-68-3
Lock Date: 06/16/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Natural Death 2 3 3 2 3
Moribund Sacrifice 1 1 3
Survivors
Terminal Sacrifice 12 14 12 12 13 9
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%) 6 (40%)
Infiltration Cellular 3 (20%) 2 (13%)
Inflammation, Chronic Active 12 (80%) 14 (93%) 11 (73%) 14 (93%) 13 (87%) 11 (73%)
Necrosis 1 (7%)
Pigmentation 11 (73%) 11 (73%) 9 (60%) 13 (87%) 5 (33%) 2 (13%)
Bile Duct, Hyperplasia 1 (7%)
Hepatocyte, Necrosis 2 (13%) 2 (13%) 2 (13%) 3 (20%) 4 (27%) 2 (13%)
Stomach, Forestomach (15) (15) (15) (15) (15) (15)
Hyperkeratosis 1 (7%) 3 (20%) 3 (20%) 4 (27%) 4 (27%)
Inflammation 2 (13%)
Epithelium, Hyperplasia 1 (7%) 2 (13%)
Epithelium, Ulcer 1 (7%)
Tooth (4) (3) (3) (1)
Inflammation, Chronic Active 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (15) (15) (15) (15) (15) (15)
Infiltration Cellular 1 (7%)
Inflammation, Chronic Active 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%)
Necrosis 1 (7%)
Capsule, Hyperplasia 1 (7%) 4 (27%) 7 (47%) 2 (13%) 1 (7%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pituitary Gland (15) (15) (14) (15) (15) (15)
Pars Distalis, Cyst 3 (20%) 2 (14%) 2 (13%) 4 (27%) 2 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15) (15) (15)
Cyst 1 (7%) 1 (7%) 2 (13%)
Uterus (15) (15) (15) (15) (15) (15)
Hydrometra 1 (7%) 2 (13%)
Endometrium, Hyperplasia, Cystic 11 (73%) 9 (60%) 7 (47%) 10 (67%) 11 (73%) 7 (47%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (15) (14) (13) (12) (15) (14)
Hematopoietic Cell Proliferation 2 (14%)
Inguinal, Hematopoietic Cell Proliferation 1 (7%)
Inguinal, Hyperplasia 1 (7%)
Inguinal, Infiltration Cellular 1 (7%)
Inguinal, Infiltration Cellular, Plasma Cell 1 (7%)
Mediastinal, Hematopoietic Cell Proliferation 1 (7%)
Mediastinal, Hyperplasia 1 (7%)
Mediastinal, Infiltration Cellular 3 (20%) 1 (7%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (7%)
Mediastinal, Necrosis, Lymphoid 1 (8%)
Lymph Node, Mandibular (15) (15) (15) (15) (15) (13)
Hematopoietic Cell Proliferation 1 (7%) 8 (62%)
Hyperplasia 3 (20%) 1 (7%) 5 (33%) 3 (20%) 1 (8%)
Infiltration Cellular 1 (7%) 2 (13%) 2 (15%)
Infiltration Cellular, Plasma Cell 1 (7%) 1 (8%)
Necrosis, Lymphoid 1 (7%) 1 (7%)
Lymph Node, Mesenteric (14) (15) (15) (14) (15) (15)
Infiltration Cellular 4 (27%)
Necrosis, Lymphoid 1 (7%)
Spleen (15) (15) (15) (15) (15) (15)
Depletion Cellular 2 (13%) 1 (7%) 2 (13%) 1 (7%) 2 (13%) 3 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 2 (13%) 11 (73%) 11 (73%)
Infiltration Cellular 1 (7%) 1 (7%)
Necrosis, Lymphoid 1 (7%) 1 (7%) 1 (7%)
Thymus (15) (15) (15) (14) (14) (15)
Atrophy 3 (20%) 2 (13%) 2 (14%) 3 (21%) 6 (40%)
Pigmentation 1 (7%)
Thymocyte, Necrosis 1 (7%) 2 (13%) 2 (14%) 5 (33%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15) (15) (15)
Epidermis, Skin, Site of Application,
Hyperplasia 5 (33%) 14 (93%) 14 (93%) 14 (93%)
Epidermis, Skin, Site of Application, Ulcer 1 (7%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia, Adenomatous 1 (7%)
Skin, Site of Application, Cyst Epithelial
Inclusion 1 (7%) 1 (7%)
Skin, Site of Application, Hyperkeratosis 1 (7%) 4 (27%) 14 (93%) 11 (73%) 13 (87%)
Skin, Site of Application, Inflammation,
Chronic Active 1 (7%) 9 (60%) 10 (67%) 15 (100%)
Subcutaneous Tissue, Hemorrhage 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Infiltration Cellular 1 (7%)
Infiltration Cellular, Mononuclear Cell 1 (7%)
Inflammation, Chronic Active 1 (7%) 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%) 2 (13%) 1 (7%) 1 (7%) 1 (7%) 1 (7%)
Nephropathy 3 (20%) 2 (13%)
Polyarteritis 1 (7%)
Cortex, Cyst 2 (13%)
Papilla, Necrosis 1 (7%)
Renal Tubule, Degeneration 1 (7%)
Renal Tubule, Hyperplasia 1 (7%) 1 (7%)
Renal Tubule, Necrosis 2 (13%)
Renal Tubule, Regeneration 1 (7%) 1 (7%) 2 (13%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Natural Death 3 2 5
Moribund Sacrifice 1 1
Survivors
Terminal Sacrifice 12 14 15 15 12 10
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (15) (15)
Atrophy 1 (7%)
Hematopoietic Cell Proliferation 2 (13%)
Infiltration Cellular 5 (33%) 3 (20%)
Inflammation, Chronic Active 5 (33%) 11 (73%) 10 (67%) 13 (87%) 13 (87%) 5 (33%)
Mineralization 1 (7%)
Myelodysplasia 5 (33%)
Pigmentation 1 (7%) 1 (7%)
Hepatocyte, Necrosis 1 (7%) 1 (7%) 1 (7%) 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 1 (7%)
Salivary Glands (1) (1) (1) (2)
Parotid Gland, Infiltration Cellular 1 (50%)
Stomach, Forestomach (15) (15) (15) (15) (15) (15)
Hyperkeratosis 2 (13%) 1 (7%) 3 (20%) 4 (27%)
Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (15) (15) (15) (15) (15) (15)
Infiltration Cellular 3 (20%)
Inflammation, Chronic Active 3 (20%) 1 (7%)
Myelodysplasia 3 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15) (15) (15)
Hypertrophy 7 (47%) 10 (67%) 3 (20%) 5 (33%) 1 (7%) 3 (20%)
Myelodysplasia 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Medulla (15) (15) (15) (15) (15) (15)
Infiltration Cellular 2 (13%)
Myelodysplasia 2 (13%)
Pituitary Gland (15) (14) (15) (15) (15) (15)
Pars Distalis, Cyst 1 (7%) 3 (20%)
Thyroid Gland (15) (15) (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%)
Myelodysplasia 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (14) (15) (15) (15) (15)
Infiltration Cellular 5 (33%) 5 (33%)
Inflammation, Chronic Active 1 (7%) 4 (27%)
Myelodysplasia 5 (33%)
Bilateral, Hypospermia 1 (7%)
Unilateral, Hypospermia 1 (7%) 1 (7%) 2 (13%)
Preputial Gland (1)
Duct, Ectasia 1 (100%)
Testes (15) (15) (15) (15) (15) (15)
Cyst 2 (13%) 1 (7%) 1 (7%) 1 (7%)
Bilateral, Germinal Epithelium, Degeneration 1 (7%)
Unilateral, Germinal Epithelium, Degeneration 1 (7%) 1 (7%) 2 (13%) 1 (7%) 4 (27%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (1)
Myeloid Cell, Hyperplasia 1 (100%)
Lymph Node (14) (15) (14) (13) (15) (14)
Hyperplasia 1 (7%)
Infiltration Cellular, Plasma Cell 1 (7%)
Inflammation, Chronic Active 1 (7%)
Myelodysplasia 1 (7%)
Axillary, Hyperplasia, Lymphoid 1 (7%)
Axillary, Infiltration Cellular 1 (7%) 1 (7%)
Axillary, Infiltration Cellular, Plasma Cell 1 (7%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Axillary, Infiltration Cellular, Histiocyte 1 (7%)
Inguinal, Myelodysplasia 1 (7%)
Mediastinal, Hyperplasia 1 (7%)
Mediastinal, Infiltration Cellular 4 (27%) 2 (14%)
Mediastinal, Myelodysplasia 1 (7%)
Lymph Node, Mandibular (15) (15) (15) (15) (15) (15)
Hematopoietic Cell Proliferation 3 (20%)
Hyperplasia 2 (13%) 1 (7%) 2 (13%)
Hyperplasia, Plasma Cell 1 (7%)
Infiltration Cellular 5 (33%) 6 (40%)
Infiltration Cellular, Plasma Cell 1 (7%) 6 (40%)
Myelodysplasia 2 (13%)
Necrosis, Lymphoid 2 (13%)
Lymph Node, Mesenteric (12) (15) (15) (15) (15) (14)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%)
Infiltration Cellular 4 (27%) 2 (14%)
Myelodysplasia 3 (21%)
Necrosis, Lymphoid 1 (7%)
Spleen (15) (15) (15) (15) (15) (15)
Atrophy 1 (7%)
Depletion Cellular 2 (13%) 2 (13%)
Hematopoietic Cell Proliferation 1 (7%) 2 (13%) 1 (7%) 2 (13%) 9 (60%) 8 (53%)
Infiltration Cellular 1 (7%) 4 (27%)
Myelodysplasia 4 (27%)
Necrosis, Lymphoid 2 (13%) 1 (7%)
Thymus (15) (15) (15) (15) (14) (14)
Atrophy 4 (27%) 1 (7%) 2 (13%) 4 (29%) 5 (36%)
Myelodysplasia 3 (21%)
Thymocyte, Necrosis 2 (14%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15) (15) (15)
Dermis, Skin, Site of Application, Necrosis 1 (7%)
Epidermis, Skin, Site of Application,
Hyperplasia 3 (20%) 8 (53%) 10 (67%) 14 (93%)
Epidermis, Skin, Site of Application, Ulcer 1 (7%)
Skin, Site of Application, Cyst Epithelial
Inclusion 1 (7%)
Skin, Site of Application, Hyperkeratosis 1 (7%) 2 (13%) 6 (40%) 10 (67%) 13 (87%)
Skin, Site of Application, Inflammation,
Chronic Active 2 (13%) 5 (33%) 12 (80%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:37:45
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Infiltration Cellular 1 (7%) 3 (20%)
Inflammation, Chronic Active 1 (7%) 2 (13%)
Myelodysplasia 3 (20%)
Alveolar Epithelium, Hyperplasia 1 (7%)
Mediastinum, Infiltration Cellular 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Hydronephrosis 1 (7%)
Infarct 1 (7%) 2 (13%)
Infiltration Cellular 2 (13%) 3 (20%)
Inflammation, Chronic Active 1 (7%) 4 (27%) 4 (27%) 3 (20%)
Mineralization 1 (7%)
Myelodysplasia 4 (27%)
Nephropathy 6 (40%) 1 (7%)
Pigmentation 1 (7%)
Cortex, Cyst 1 (7%) 1 (7%) 1 (7%) 1 (7%)
Renal Tubule, Dilatation 1 (7%)
Renal Tubule, Regeneration 1 (7%) 2 (13%) 3 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
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