TDMS Study 88133-04 Pathology Tables
NTP Experiment-Test: 88133-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRIMETHYLOLPROPANE TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:52:32
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 15625-89-5
Lock Date: 10/09/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88133-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRIMETHYLOLPROPANE TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:52:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Inflammation, Chronic Active 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Vacuolization Cytoplasmic 8 (80%) 9 (90%)
Subcapsular, Hyperplasia 7 (70%) 9 (90%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (1) (10)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88133-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRIMETHYLOLPROPANE TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:52:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Dermis, Inflammation, Chronic Active 1 (10%) 2 (20%)
Dermis, Skin, Site of Application, Fibrosis 1 (10%) 7 (70%)
Dermis, Skin, Site of Application,
Inflammation, Chronic Active 7 (70%) 10 (100%) 10 (100%) 10 (100%)
Epidermis, Skin, Site of Application,
Degeneration 5 (50%) 9 (90%)
Epidermis, Skin, Site of Application,
Hyperplasia 3 (30%) 10 (100%) 9 (90%) 10 (100%)
Epidermis, Skin, Site of Application,
Inflammation, Suppurative 1 (10%) 1 (10%) 2 (20%) 5 (50%)
Epidermis, Skin, Site of Application,
Necrosis 1 (10%) 2 (20%) 8 (80%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 1 (10%) 10 (100%) 10 (100%) 10 (100%)
Skin, Site of Application, Hyperkeratosis 3 (30%) 10 (100%) 9 (90%) 8 (80%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88133-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRIMETHYLOLPROPANE TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:52:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Inflammation, Suppurative 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Dermis, Skin, Site of Application, Fibrosis 7 (70%)
Dermis, Skin, Site of Application,
Inflammation, Chronic Active 1 (10%) 2 (20%) 10 (100%) 9 (90%) 10 (100%)
Epidermis, Skin, Site of Application,
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88133-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRIMETHYLOLPROPANE TRIACRYLATE Date: 12/08/99
Route: SKIN APPLICATION Time: 08:52:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Degeneration 4 (40%) 8 (80%) 9 (90%)
Epidermis, Skin, Site of Application,
Hyperplasia 3 (30%) 10 (100%) 10 (100%) 10 (100%)
Epidermis, Skin, Site of Application,
Inflammation, Suppurative 1 (10%) 1 (10%) 8 (80%)
Epidermis, Skin, Site of Application,
Necrosis 1 (10%) 1 (10%) 2 (20%) 7 (70%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 9 (90%) 10 (100%) 10 (100%)
Skin, Site of Application, Hyperkeratosis 3 (30%) 8 (80%) 8 (80%) 10 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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