TDMS Study 88133-06 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Battelle Columbus TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) DATE: 07/12/02
EXPERIMENT: 88133 TEST: 06 TIME: 08:46:58
PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK ROUTE: SKIN APPLICATION NTP: C88133B
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Final#2
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 MG/KG
INCLUDE 002 0 MG/KG
INCLUDE 003 0.75 MG/KG
INCLUDE 004 0.75 MG/KG
INCLUDE 005 1.5 MG/KG
INCLUDE 006 1.5 MG/KG
INCLUDE 007 3 MG/KG
INCLUDE 008 3 MG/KG
INCLUDE 009 6 MG/KG
INCLUDE 010 6 MG/KG
INCLUDE 011 12 MG/KG
INCLUDE 012 12 MG/KG
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BATTELLE COLUMBUS TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) DATE: 07/12/02
EXPERIMENT: 88133 TEST: 06 TIME: 8:52:15
SPECIES: MICE, TG.AC HEMI
TEST TYPE: SUBCHRONIC (26-WEEK) ROUTE: DERMAL NTP: 88133B
CONT: NO1-ES-65406 CAS: 15625-89-5
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
SUBCHRONIC (26-WEEK) DERMAL STUDY OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
==========================================================================================================================
WEEK 0 MG/KG 0.75 MG/KG 1.5 MG/KG 3 MG/KG 6 MG/KG
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 22.1 15 21.9 99.1 15 21.3 96.4 15 21.9 99.1 15 21.7 98.2 15
1 22.1 15 21.9 99.1 15 21.3 96.4 15 21.9 99.1 15 21.7 98.2 15
2 22.7 15 22.5 99.1 15 22.5 99.1 15 22.9 100.9 15 21.2 93.4 15
3 24.3 15 23.3 95.9 15 24.0 98.8 15 23.9 98.4 15 23.0 94.7 15
4 25.3 15 24.5 96.8 15 24.8 98.0 15 25.1 99.2 15 24.9 98.4 15
5 25.9 15 25.2 97.3 15 26.2 101.2 15 26.4 101.9 15 25.9 100.0 15
6 27.2 15 26.3 96.7 15 27.5 101.1 15 26.6 97.8 15 27.3 100.4 15
7 27.3 15 26.8 98.2 15 27.9 102.2 15 27.4 100.4 15 27.6 101.1 15
8 28.2 15 27.5 97.5 15 28.5 101.1 15 28.1 99.6 15 27.9 98.9 15
9 28.0 15 26.7 95.4 15 28.7 102.5 15 28.5 101.8 15 27.9 99.6 15
10 28.6 15 27.1 94.8 15 29.1 101.7 15 28.6 100.0 15 28.3 99.0 15
11 29.2 15 27.9 95.5 15 29.5 101.0 15 29.0 99.3 15 28.8 98.6 15
12 29.7 15 28.3 95.3 15 30.6 103.0 14 29.2 98.3 15 28.8 97.0 15
13 29.3 15 28.7 98.0 15 30.3 103.4 14 29.7 101.4 15 28.7 98.0 15
14 30.0 15 29.2 97.3 15 29.9 99.7 14 30.3 101.0 15 29.3 97.7 14
15 30.4 15 28.6 94.1 15 31.7 104.3 13 31.1 102.3 15 30.2 99.3 14
16 30.3 14 29.3 96.7 15 31.4 103.6 13 31.0 102.3 15 29.8 98.3 14
17 30.1 14 29.9 99.3 15 31.7 105.3 13 31.7 105.3 15 30.3 100.7 14
18 31.3 14 30.4 97.1 15 31.8 101.6 13 32.0 102.2 15 31.3 100.0 14
19 31.4 14 30.1 95.9 15 32.3 102.9 13 32.2 102.5 15 30.5 97.1 14
20 31.3 14 30.9 98.7 15 31.2 99.7 13 32.7 104.5 14 30.6 97.8 14
21 31.2 14 30.2 96.8 15 32.6 104.5 13 32.5 104.2 14 30.8 98.7 14
22 31.9 14 31.2 97.8 15 33.2 104.1 13 33.4 104.7 14 31.2 97.8 14
23 32.1 14 31.1 96.9 15 32.6 101.6 13 32.9 102.5 14 31.0 96.6 14
24 31.7 14 31.9 100.6 15 33.9 106.9 12 33.8 106.6 14 31.9 100.6 14
25 33.1 14 32.0 96.7 15 35.3 106.6 12 34.3 103.6 14 30.8 93.1 14
26 32.5 14 32.1 98.8 15 33.8 104.0 12 34.3 105.5 14 31.6 97.2 14
27 33.1 14 32.2 97.3 15 35.2 106.3 12 34.5 104.2 14 32.4 97.9 13
28 32.6 14 32.5 99.7 15 36.3 111.3 12 33.8 103.7 14 32.8 100.6 13
TERM. SAC. 14 15 12 14 13
==========================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
SUBCHRONIC (26-WEEK) DERMAL STUDY OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
===============================
12 MG/KG
WEEK ----------------
AV.WT. PERCENT NO.
(GRAMS) OF CNTL (A)
==============================
B 21.0 95.0 15
1 21.0 95.0 15
2 22.7 100.0 15
3 23.9 98.4 15
4 24.8 98.0 15
5 26.2 101.2 15
6 26.7 98.2 15
7 27.2 99.6 15
8 28.1 99.6 15
9 28.0 100.0 15
10 28.2 98.6 15
11 28.5 97.6 15
12 28.9 97.3 15
13 29.1 99.3 15
14 29.6 98.7 15
15 30.0 98.7 15
16 30.1 99.3 15
17 30.5 101.3 15
18 30.7 98.1 15
19 31.3 99.7 15
20 31.9 101.9 15
21 31.7 101.6 15
22 32.0 100.3 15
23 32.2 100.3 15
24 32.9 103.8 13
25 32.9 99.4 13
26 33.1 101.8 13
27 33.5 101.2 12
28 33.0 101.2 12
TERM. SAC. 11
===============================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DERMAL STUDY OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
==========================================================================================================================
WEEK 0 MG/KG 0.75 MG/KG 1.5 MG/KG 3 MG/KG 6 MG/KG
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 18.6 15 18.4 98.9 15 18.5 99.5 15 18.6 100.0 15 18.7 100.5 15
1 18.6 15 18.4 98.9 15 18.5 99.5 15 18.6 100.0 15 18.7 100.5 15
2 19.3 15 19.0 98.4 15 19.4 100.5 15 18.6 96.4 15 18.7 96.9 15
3 20.4 15 20.9 102.5 15 20.9 102.5 15 20.7 101.5 15 20.1 98.5 15
4 21.7 15 21.6 99.5 15 21.8 100.5 15 21.2 97.7 15 21.5 99.1 15
5 22.8 15 22.7 99.6 15 22.8 100.0 15 22.8 100.0 15 22.3 97.8 15
6 23.3 15 23.1 99.1 15 23.6 101.3 15 23.6 101.3 15 23.4 100.4 15
7 23.8 15 23.7 99.6 15 23.3 97.9 15 23.6 99.2 15 23.0 96.6 15
8 22.8 15 23.6 103.5 15 23.6 103.5 15 24.5 107.5 15 24.0 105.3 15
9 24.1 15 23.4 97.1 15 23.5 97.5 15 23.0 95.4 15 23.7 98.3 15
10 24.3 15 24.6 101.2 15 25.0 102.9 13 24.3 100.0 15 24.5 100.8 15
11 24.4 15 25.2 103.3 15 25.3 103.7 13 25.0 102.5 15 24.9 102.0 15
12 24.6 15 25.2 102.4 15 25.6 104.1 13 24.8 100.8 15 25.0 101.6 15
13 25.1 15 25.5 101.6 15 25.6 102.0 13 25.6 102.0 15 24.8 98.8 15
14 24.7 15 25.8 104.5 15 25.7 104.0 13 25.3 102.4 15 25.4 102.8 15
15 26.2 15 25.8 98.5 15 26.9 102.7 13 26.0 99.2 15 26.0 99.2 15
16 25.7 15 25.8 100.4 15 26.0 101.2 13 26.0 101.2 15 25.7 100.0 15
17 26.1 15 26.4 101.1 15 26.9 103.1 13 26.3 100.8 15 26.6 101.9 15
18 26.1 15 26.6 101.9 15 26.7 102.3 13 26.1 100.0 15 26.2 100.4 15
19 25.5 15 26.2 102.7 15 26.5 103.9 12 26.3 103.1 14 26.3 103.1 15
20 26.0 15 26.6 102.3 15 27.3 105.0 12 27.3 105.0 14 27.2 104.6 15
21 26.3 15 26.8 101.9 15 27.6 104.9 12 27.0 102.7 14 27.1 103.0 15
22 27.0 15 26.7 98.9 15 27.4 101.5 12 26.9 99.6 14 26.3 97.4 15
23 27.2 15 26.7 98.2 15 26.9 98.9 12 27.5 101.1 14 26.4 97.1 15
24 27.5 15 26.9 97.8 15 28.4 103.3 12 27.6 100.4 14 27.8 101.1 14
25 27.5 15 26.9 97.8 15 28.4 103.3 12 27.6 100.4 14 27.6 100.4 14
26 27.1 15 27.3 100.7 15 28.1 103.7 12 26.6 98.2 14 27.3 100.7 14
27 27.9 15 27.5 98.6 14 27.4 98.2 12 27.9 100.0 14 26.4 94.6 14
28 28.2 15 27.6 97.9 14 28.9 102.5 12 28.5 101.1 14 27.9 98.9 14
TERM. SAC. 15 14 12 14 14
==========================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DERMAL STUDY OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
===============================
12 MG/KG
WEEK ----------------
AV.WT. PERCENT NO.
(GRAMS) OF CNTL (A)
==============================
B 18.5 99.5 15
1 18.5 99.5 15
2 19.4 100.5 15
3 20.2 99.0 15
4 21.7 100.0 15
5 22.3 97.8 15
6 22.5 96.6 15
7 23.2 97.5 15
8 23.3 102.2 15
9 23.8 98.8 15
10 23.2 95.5 15
11 24.5 100.4 15
12 24.8 100.8 15
13 25.2 100.4 15
14 25.3 102.4 15
15 25.5 97.3 15
16 24.6 95.7 15
17 26.2 100.4 15
18 25.8 98.9 14
19 26.8 105.1 14
20 27.4 105.4 14
21 27.2 103.4 14
22 27.5 101.9 14
23 27.4 100.7 14
24 28.2 102.5 14
25 27.6 100.4 14
26 28.4 104.8 13
27 28.7 102.9 13
28 28.7 101.8 12
TERM. SAC. 12
===============================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.