TDMS Study 88133-06 Pathology Tables
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
Final#3
Facility: Battelle Columbus Laboratory
Chemical CAS #: 15625-89-5
Lock Date: 06/16/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 001 0 MG/KG
Include 004 0.75 MG/KG
Include 003 0.75 MG/KG
Include 006 1.5 MG/KG
Include 005 1.5 MG/KG
Include 008 3 MG/KG
Include 007 3 MG/KG
Include 010 6 MG/KG
Include 009 6 MG/KG
Include 012 12 MG/KG
Include 011 12 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 2 1 1 3
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 14 12 14 14 12
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%) 2 (13%)
Lymphoma Malignant 1 (7%)
Salivary Glands (1) (1)
Carcinoma 1 (100%)
Stomach, Forestomach (15) (15) (15) (15) (15) (15)
Squamous Cell Papilloma 3 (20%) 4 (27%) 3 (20%) 1 (7%) 4 (27%) 6 (40%)
Squamous Cell Papilloma, Multiple 1 (7%) 1 (7%) 1 (7%) 1 (7%) 1 (7%) 3 (20%)
Tooth (1) (4) (3) (1) (3) (2)
Odontogenic Tumor 1 (100%) 4 (100%) 2 (67%) 3 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 2 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
Uterus (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
Vagina (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (11) (14) (13) (10) (13) (12)
Mediastinal, Leukemia Erythrocytic 2 (17%)
Lymph Node, Mandibular (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Lymph Node, Mesenteric (15) (14) (14) (15) (15) (15)
Leukemia Erythrocytic 2 (13%)
Spleen (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%) 2 (13%)
Lymphoma Malignant 1 (7%)
Thymus (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 2 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15) (15) (15)
Squamous Cell Papilloma 1 (7%) 1 (7%)
Skin, Site of Application, Leukemia
Erythrocytic 2 (13%)
Skin, Site of Application, Squamous Cell
Carcinoma 1 (7%) 1 (7%) 1 (7%)
Skin, Site of Application, Squamous Cell
Papilloma 1 (7%) 6 (40%)
Skin, Site of Application, Squamous Cell
Papilloma, Multiple 5 (33%) 15 (100%)
Vulva, Squamous Cell Papilloma 1 (7%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1)
Osteosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 1 (7%) 1 (7%)
Leukemia Erythrocytic 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 1 (7%) 1 (7%) 2 (13%)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 6 9 6 5 12 15
Total Primary Neoplasms 7 13 7 6 21 29
Total Animals with Benign Neoplasms 5 5 4 4 11 15
Total Benign Neoplasms 5 7 4 5 17 24
Total Animals with Malignant Neoplasms 1 2 1 1 1 3
Total Malignant Neoplasms 1 2 1 1 1 4
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 4 2 3 1
Total Uncertain Neoplasms 1 4 2 3 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 3 1 2 4
Survivors
Terminal Sacrifice 14 15 12 14 13 11
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
Lymphoma Malignant 1 (7%)
Salivary Glands (1) (1) (2)
Carcinoma 1 (100%) 1 (100%) 1 (50%)
Stomach, Forestomach (15) (15) (15) (15) (15) (15)
Squamous Cell Papilloma 3 (20%) 4 (27%) 1 (7%) 2 (13%) 2 (13%) 2 (13%)
Squamous Cell Papilloma, Multiple 2 (13%) 3 (20%) 2 (13%) 1 (7%)
Tooth (1) (3) (1) (2) (1) (1)
Odontogenic Tumor 1 (100%) 3 (100%) 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (15) (15) (15) (15) (15) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (15) (15) (15) (14) (15) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (13) (13) (14) (15) (14) (14)
Mediastinal, Lymphoma Malignant 1 (7%)
Lymph Node, Mandibular (15) (14) (15) (15) (14) (13)
Leukemia Erythrocytic 1 (8%)
Lymphoma Malignant 1 (7%)
Lymph Node, Mesenteric (15) (14) (14) (15) (15) (12)
Leukemia Erythrocytic 1 (8%)
Lymphoma Malignant 1 (7%)
Spleen (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
Lymphoma Malignant 1 (7%)
Thymus (15) (15) (14) (15) (15) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15) (15) (15)
Squamous Cell Papilloma 2 (13%)
Skin, Site of Application, Squamous Cell
Papilloma 2 (13%)
Skin, Site of Application, Squamous Cell
Papilloma, Multiple 12 (80%) 13 (87%)
Subcutaneous Tissue, Fibrosarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (14)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 1 (7%)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 88133-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02
Route: SKIN APPLICATION Time: 10:04:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 6 8 4 6 12 13
Total Primary Neoplasms 6 10 4 8 16 20
Total Animals with Benign Neoplasms 5 7 1 5 12 13
Total Benign Neoplasms 5 7 1 6 15 17
Total Animals with Malignant Neoplasms 2 1 2
Total Malignant Neoplasms 2 2 2
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 3 1 1 1
Total Uncertain Neoplasms 1 3 1 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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