TDMS Study 88133-06 Pathology Tables
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
Final#2
Facility: Battelle Columbus Laboratory
Chemical CAS #: 15625-89-5
Lock Date: 06/16/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 001 0 MG/KG
Include 004 0.75 MG/KG
Include 003 0.75 MG/KG
Include 006 1.5 MG/KG
Include 005 1.5 MG/KG
Include 008 3 MG/KG
Include 007 3 MG/KG
Include 010 6 MG/KG
Include 009 6 MG/KG
Include 012 12 MG/KG
Include 011 12 MG/KG
Page 1
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 3| 3| 3| 4| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 | 15 1.1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0|
Hepatocyte, Necrosis | 1 2 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 3| 3| 3| 4| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 1 1 1 1 2 2 2 2 | 10 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + M M M + M + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 | 7 1.1|
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 3| 3| 3| 4| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 4| 4| 4| 4| 4| 3| 4| 4| 4| 3| 4| 4| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.75 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | 14 1.1|
Pigmentation | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 15 1.1|
Hepatocyte, Necrosis | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Hydrometra | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 4| 4| 4| 4| 4| 3| 4| 4| 4| 3| 4| 4| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.75 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Cervix, Inflammation, Chronic Active | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 1 1 1 3 2 1 2 1 2 2 | 11 1.6|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 4 3 3 | 3 3.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 2 1 1 2 2 2 2 2 2 2 2 2 2 | 13 1.8|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 4| 4| 4| 4| 4| 3| 4| 4| 4| 3| 4| 4| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.75 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 6| 9| 9| 6| 9| 9| 2| 9| 9| 9| 9| 9| | |
| 4| 3| 4| 3| 4| 4| 3| 4| 4| 2| 4| 3| 4| 4| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infiltration Cellular | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 2 1 1 1 | 13 1.2|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0|
Hepatocyte, Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 6| 9| 9| 6| 9| 9| 2| 9| 9| 9| 9| 9| | |
| 4| 3| 4| 3| 4| 4| 3| 4| 4| 2| 4| 3| 4| 4| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Endometrium, Hyperplasia, Cystic | 2 1 1 2 2 1 1 | 7 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | M + + + + M + + + + + + + + + | 13 |
Mediastinal, Infiltration Cellular | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia | 2 3 | 2 2.5|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular | 3 | 1 3.0|
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 3 2 | 3 2.3|
Hematopoietic Cell Proliferation | 1 2 1 2 2 1 2 1 2 | 9 1.6|
Hyperplasia, Lymphoid | 4 3 | 2 3.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 4 3 3 | 3 3.3|
Thymocyte, Necrosis | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 | 1 2.0|
Skin, Site of Application, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 6| 9| 9| 6| 9| 9| 2| 9| 9| 9| 9| 9| | |
| 4| 3| 4| 3| 4| 4| 3| 4| 4| 2| 4| 3| 4| 4| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperkeratosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 4| 3| 4| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
3 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 13 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 13 1.0|
Hepatocyte, Necrosis | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Angiectasis | 1 | 1 1.0|
Pars Distalis, Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 4| 3| 4| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
3 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Hydrometra | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 1 2 2 2 1 2 2 | 8 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | M + M + + + + M + + M + + + M | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 | 6 1.8|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 4 2 | 2 3.0|
Thymocyte, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia, Focal | 4 | 1 4.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 1 1 1 | 4 1.0|
Skin, Site of Application, | | |
Hyperkeratosis | 1 1 1 1 1 1 1 | 7 1.0|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 4| 3| 4| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
3 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| | |
| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| 4| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
6 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 3 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 14 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 14 1.0|
Hepatocyte, Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| | |
| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| 4| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
6 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Hydrometra | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 2 2 1 | 8 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | M + + + M + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 3 3 | 2 3.0|
Hyperplasia, Plasma Cell | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 1 3 | 2 2.0|
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 2 1 | 8 1.8|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia, Focal | 3 | 1 3.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 1 1 1 1 2 1 1 2 1 1 1 2 1 1 | 15 1.2|
Skin, Site of Application, | | |
Hyperkeratosis | 2 1 1 1 1 1 1 1 1 1 1 1 1 2 | 14 1.1|
Skin, Site of Application, | | |
Hyperplasia | 1 | 1 1.0|
Skin, Site of Application, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| | |
| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| 4| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
6 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 14 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Renal Tubule, Regeneration | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 1| 9| 7| 9| 9| 8| 9| 9| | |
| 4| 3| 3| 3| 4| 3| 4| 8| 4| 6| 4| 4| 9| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 | 6 1.8|
Infiltration Cellular | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 1 1 1 1 1 1 | 8 1.3|
Myelodysplasia | 2 3 | 2 2.5|
Pigmentation | 1 1 1 1 | 4 1.0|
Hepatocyte, Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
Parotid Gland, Infiltration Cellular | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Fibrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 | 1 1.0|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 1| 9| 7| 9| 9| 8| 9| 9| | |
| 4| 3| 3| 3| 4| 3| 4| 8| 4| 6| 4| 4| 9| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Inflammation, Chronic Active | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Hydrometra | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 1 1 1 2 2 2 2 1 | 9 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + M M + + + + + + + M + + + + | 12 |
Hematopoietic Cell Proliferation | 2 4 | 2 3.0|
Hyperplasia | 3 4 | 2 3.5|
Inguinal, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Inguinal, Hyperplasia | 2 | 1 2.0|
Inguinal, Infiltration Cellular, | | |
Plasma Cell | 2 4 | 2 3.0|
Inguinal, Myelodysplasia | 2 3 | 2 2.5|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 2 2 2 2 2 | 5 2.0|
Mediastinal, Infiltration Cellular | 2 2 | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 3 2 2 1 2 | 6 2.0|
Hyperplasia | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 1| 9| 7| 9| 9| 8| 9| 9| | |
| 4| 3| 3| 3| 4| 3| 4| 8| 4| 6| 4| 4| 9| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Infiltration Cellular | 3 | 1 3.0|
Infiltration Cellular, Plasma Cell | 2 2 | 2 2.0|
Myelodysplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 3 2 2 1 | 4 2.0|
Infiltration Cellular | 3 2 | 2 2.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 2 2 3 4 2 4 4 2 | 10 2.7|
Infiltration Cellular | 1 | 1 1.0|
Myelodysplasia | 3 1 | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 4 4 3 | 3 3.7|
Thymocyte, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia, Focal | 2 4 2 3 2 2 3 4 | 8 2.8|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 2 3 2 3 2 2 1 2 2 2 2 2 2 2 | 15 2.0|
Skin, Site of Application, | | |
Hyperkeratosis | 1 1 2 1 2 1 2 1 2 2 2 2 2 | 13 1.6|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 2 2 1 2 | 12 1.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 1| 9| 7| 9| 9| 8| 9| 9| | |
| 4| 3| 3| 3| 4| 3| 4| 8| 4| 6| 4| 4| 9| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Mediastinum, Infiltration Cellular | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 1 | 3 1.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 1 | 1 1.0|
Renal Tubule, Cyst | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 2| 3| 2| 2| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 | 7 1.1|
Hepatocyte, Necrosis | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 3 1 2 2 1 1 1 | 7 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Unilateral, Hypospermia | 4 3 4 4 | 4 3.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 2| 3| 2| 2| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Preputial Gland | + | 1 |
Duct, Ectasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 2 | 2 2.0|
Unilateral, Germinal Epithelium, | | |
Degeneration | 3 2 2 3 | 4 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + M + + + M + | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 2| 3| 2| 2| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + | 15 |
Interstitium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Nephropathy | 1 1 1 | 3 1.0|
Renal Tubule, Cyst | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Regeneration | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.75 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Basophilic Focus | X | 1 |
Infarct | 4 | 1 4.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Mineralization | 1 | 1 1.0|
Pigmentation | 1 1 | 2 1.0|
Hepatocyte, Necrosis | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 1 2 2 2 2 | 5 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.75 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Inflammation, Chronic Active | 1 2 | 2 1.5|
Bilateral, Hypospermia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Bilateral, Germinal Epithelium, | | |
Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | M + + + + + + + + M + + + + + | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + | 14 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 2 2 1 | 4 1.5|
Hyperplasia, Lymphoid | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.75 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Nephropathy | 1 1 1 1 1 1 | 6 1.0|
Renal Tubule, Cyst | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 7| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 5| 4| 3| 2| 7| 2| 2| 3| 3| 2| 2| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Necrosis | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 2 2 2 1 2 1 1 2 2 | 9 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 7| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 5| 4| 3| 2| 7| 2| 2| 3| 3| 2| 2| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Unilateral, Hypospermia | 4 4 4 | 3 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
Unilateral, Germinal Epithelium, | | |
Degeneration | 2 3 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Plasma Cell | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Depletion Cellular | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + | 14 |
Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia, Focal | 4 | 1 4.0|
Skin, Site of Application, | | |
Hyperkeratosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 7| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 5| 4| 3| 2| 7| 2| 2| 3| 3| 2| 2| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Interstitium, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 | 1 1.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Regeneration | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 3| 2| 3| 2| 3| 2| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 8 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 1 1 1 2 1 1 1 2 | 8 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + + + + + | 14 |
Pars Distalis, Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Unilateral, Hypospermia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 3| 2| 3| 2| 3| 2| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Unilateral, Germinal Epithelium, | | |
Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 2 | 2 1.5|
Hyperplasia, Lymphoid | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
Skin, Site of Application, | | |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 15 1.0|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 3| 2| 3| 2| 3| 2| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Renal Tubule, Regeneration | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| | |
DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 0| 3| 2| 3| 2| 2| 2| 3| 3| 2| 2| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
6 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 7 1.0|
Hepatocyte, Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Epithelium, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 2 1 1 2 1 | 5 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| | |
DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 0| 3| 2| 3| 2| 2| 2| 3| 3| 2| 2| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
6 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Unilateral, Hypospermia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Unilateral, Germinal Epithelium, | | |
Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + M + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + I + + | 14 |
Hyperplasia, Plasma Cell | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 1 | 1 1.0|
Depletion Cellular | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 2 3 2 2 | 6 2.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia, Focal | 4 | 1 4.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 1 1 1 2 2 1 2 2 1 3 1 3 2 | 14 1.7|
Skin, Site of Application, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| | |
DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 0| 3| 2| 3| 2| 2| 2| 3| 3| 2| 2| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
6 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | 14 1.1|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 | 9 1.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Infarct | 3 | 1 3.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | 1 | 1 1.0|
Glomerulus, Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 8| 9| | |
| 2| 2| 1| 2| 3| 2| 2| 3| 2| 2| 1| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
12 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 2 2 1 1 | 6 1.3|
Infiltration Cellular | 2 1 1 2 2 | 5 1.6|
Inflammation, Chronic Active | 1 1 1 1 2 1 1 2 | 8 1.3|
Myelodysplasia | 1 | 1 1.0|
Hepatocyte, Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
Mandibular, Infiltration Cellular | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 2 1 1 2 | 5 1.4|
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 8| 9| | |
| 2| 2| 1| 2| 3| 2| 2| 3| 2| 2| 1| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
12 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 3 2 2 | 3 2.3|
Myelodysplasia | 3 | 1 3.0|
Unilateral, Hypospermia | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
Germinal Epithelium, Degeneration | 1 | 1 1.0|
Unilateral, Germinal Epithelium, | | |
Degeneration | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + M + | 14 |
Hyperplasia | 3 3 3 4 | 5 3.4|
Inflammation, Chronic Active | 3 2 2 | 3 2.3|
Axillary, Infiltration Cellular | 3 | 1 3.0|
Axillary, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Inguinal, Hyperplasia | 4 | 1 4.0|
Inguinal, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 8| 9| | |
| 2| 2| 1| 2| 3| 2| 2| 3| 2| 2| 1| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
12 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Mediastinal, Infiltration Cellular | 3 2 2 | 3 2.3|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 2 2 | 3 2.0|
Mediastinal, Inflammation, Chronic | | |
Active | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + M + + + | 13 |
Hematopoietic Cell Proliferation | 1 2 | 2 1.5|
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular | 2 1 2 2 | 4 1.8|
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + M M + + + | 12 |
Infiltration Cellular | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 2 1 2 | 4 1.8|
Hematopoietic Cell Proliferation | 3 3 3 3 2 3 2 2 | 8 2.6|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 2 3 4 3 | 5 3.0|
Thymocyte, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 3 1 1 2 2 1 1 2 2 3 2 2 2 2 2 | 15 1.9|
Skin, Site of Application, | | |
Hyperkeratosis | 2 1 1 1 2 2 2 2 2 1 2 2 | 12 1.7|
Skin, Site of Application, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 88133-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) Date: 07/12/02
Route: SKIN APPLICATION Time: 08:52:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 8| 9| | |
| 2| 2| 1| 2| 3| 2| 2| 3| 2| 2| 1| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
12 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperplasia | 3 | 1 3.0|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 2 1 2 1 2 1 1 1 1 2 | 12 1.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + M + + | 14 |
Inflammation, Chronic Active | 1 2 | 2 1.5|
Mediastinum, Infiltration Cellular | 1 | 1 1.0|
Mediastinum, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Infarct | 2 | 1 2.0|
Infiltration Cellular | 1 | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 2 | 5 1.2|
Nephropathy | 1 1 1 | 3 1.0|
Renal Tubule, Cyst | 1 | 1 1.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
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