TDMS Study 88133-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) DATE: 07/12/02
EXPERIMENT: 88133 TEST: 06 TIME: 08:52:59
TEST TYPE: SUBCHRON 26-WEEK PAGE: 1
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 88133B
PATHOLOGIST: TOFT, JOHN CAS: 15625-89-5
------------------------------------------------------------------------------------------------------------------------------------
Final#2
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 MG/KG
INCLUDE 002 0 MG/KG
INCLUDE 003 0.75 MG/KG
INCLUDE 004 0.75 MG/KG
INCLUDE 005 1.5 MG/KG
INCLUDE 006 1.5 MG/KG
INCLUDE 007 3 MG/KG
INCLUDE 008 3 MG/KG
INCLUDE 009 6 MG/KG
INCLUDE 010 6 MG/KG
INCLUDE 011 12 MG/KG
INCLUDE 012 12 MG/KG
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) DATE: 07/12/02
EXPERIMENT: 88133 TEST: 06 TIME: 08:52:59
TEST TYPE: SUBCHRON 26-WEEK
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 88133B
PATHOLOGIST: TOFT, JOHN CAS: 15625-89-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Epididymis Inflammation Chronic
Epididymis: Unilateral Hypospermia
Kidney Inflammation Chronic
Liver Hematopoietic Cell Proliferation
Infiltration Cellular
Lymph Node Hyperplasia
Inflammation Chronic
Lymph Node, Mandibular Hematopoietic Cell Proliferation
Infiltration Cellular
Lymph Node: Mediastinal Infiltration Cellular
Infiltration Cellular Plasma Cell
Inflammation Chronic
Skin: Epidermis, Skin, Site of Application
Hyperplasia
Skin: Skin, Site of Application Hyperkeratosis
Inflammation Chronic
Spleen Atrophy
Hematopoietic Cell Proliferation
Stomach, Forestomach Hyperkeratosis
Testes: Unilateral, Germinal Epithelium
Degeneration
Thymus Atrophy
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Kidney Inflammation Chronic
Nephropathy
Liver Hematopoietic Cell Proliferation
Inflammation Chronic
Myelodysplasia
Pigmentation
Lymph Node Hematopoietic Cell Proliferation
Hyperplasia
Lymph Node, Mandibular Hematopoietic Cell Proliferation
Infiltration Cellular Plasma Cell
Lymph Node, Mesenteric Hematopoietic Cell Proliferation
Infiltration Cellular
Lymph Node: Inguinal Infiltration Cellular Plasma Cell
Myelodysplasia
Lymph Node: Mediastinal Hematopoietic Cell Proliferation
Infiltration Cellular
Infiltration Cellular Plasma Cell
Skin: Epidermis, Skin, Site of Application
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) DATE: 07/12/02
EXPERIMENT: 88133 TEST: 06 TIME: 08:52:59
TEST TYPE: SUBCHRON 26-WEEK
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 88133B
PATHOLOGIST: TOFT, JOHN CAS: 15625-89-5
Hyperplasia
Hyperplasia Focal
Skin: Skin, Site of Application Hyperkeratosis
Inflammation Chronic
Spleen Hematopoietic Cell Proliferation
Myelodysplasia
Thyroid Gland Inflammation Chronic
===============================================================
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/15 (47%) 5/15 (33%) 9/15 (60%) 8/15 (53%) 5/15 (33%) 5/15 (33%) |
|POLY-3 RATE (b) | 7/14.15 5/15.00 9/12.73 8/14.33 5/13.93 5/14.43 |
|POLY-3 PERCENT (g) | 49.5% 33.3% 70.7% 55.9% 35.9% 34.7% |
|TERMINAL (d) | 7/14 (50%) 5/15 (33%) 9/12 (75%) 8/14 (57%) 5/13 (39%) 4/11 (36%) |
|FIRST INCIDENCE | 192 (T) 192 (T) 192 (T) 192 (T) 192 (T) 161 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.390N P=0.300N P=0.188 P=0.500 P=0.416N P=0.542N |
|POLY 3 | P=0.186N P=0.309N P=0.234 P=0.514 P=0.367N P=0.339N |
|POLY 1.5 | P=0.182N P=0.322N P=0.267 P=0.514 P=0.363N P=0.339N |
|POLY 6 | P=0.201N P=0.302N P=0.209 P=0.507 P=0.374N P=0.353N |
|LOGISTIC REGRESSION| P=0.213N P=0.300N P=0.188 P=0.500 P=0.416N P=0.356N |
|COCH-ARM / FISHERS | P=0.192N P=0.355N P=0.358 P=0.500 P=0.355N P=0.355N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 0/12.32 0/14.27 0/14.59 0/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 0/12 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 2/15 (13%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/14.15 2/15.00 0/12.73 0/14.33 0/13.93 3/14.02 |
|POLY-3 PERCENT (g) | 0.0% 13.3% 0.0% 0.0% 0.0% 21.4% |
|TERMINAL (d) | 0/14 (0%) 2/15 (13%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 3/11 (27%) |
|FIRST INCIDENCE | --- 192 (T) --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.025 * P=0.251 (e) (e) (e) P=0.076 |
|POLY 3 | P=0.044 * P=0.245 (e) (e) (e) P=0.103 |
|POLY 1.5 | P=0.043 * P=0.241 (e) (e) (e) P=0.106 |
|POLY 6 | P=0.043 * P=0.247 (e) (e) (e) P=0.096 |
|LOGISTIC REGRESSION| (e) P=0.251 (e) (e) (e) P=0.076 |
|COCH-ARM / FISHERS | P=0.045 * P=0.241 (e) (e) (e) P=0.112 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis: Unilateral |
| Hypospermia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/15 (27%) 0/15 (0%) 2/15 (13%) 1/15 (7%) 1/15 (7%) 2/15 (13%) |
|POLY-3 RATE (b) | 4/14.15 0/15.00 2/13.18 1/14.33 1/13.93 2/14.02 |
|POLY-3 PERCENT (g) | 28.3% 0.0% 15.2% 7.0% 7.2% 14.3% |
|TERMINAL (d) | 4/14 (29%) 0/15 (0%) 1/12 (8%) 1/14 (7%) 1/13 (8%) 2/11 (18%) |
|FIRST INCIDENCE | 192 (T) --- 157 192 (T) 192 (T) 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.599 P=0.048N* P=0.400N P=0.166N P=0.189N P=0.449N |
|POLY 3 | P=0.529N P=0.038N* P=0.361N P=0.157N P=0.166N P=0.330N |
|POLY 1.5 | P=0.520N P=0.040N* P=0.354N P=0.157N P=0.164N P=0.324N |
|POLY 6 | P=0.541N P=0.037N* P=0.363N P=0.159N P=0.168N P=0.348N |
|LOGISTIC REGRESSION| P=0.508N (e) P=0.353N P=0.166N P=0.189N P=0.449N |
|COCH-ARM / FISHERS | P=0.508N P=0.050N P=0.326N P=0.165N P=0.165N P=0.326N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis: Unilateral |
| Hypospermia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 2/15 (13%) 1/15 (7%) 0/15 (0%) 1/15 (7%) 5/15 (33%) |
|POLY-3 RATE (b) | 0/14.15 2/15.00 1/12.73 0/14.33 1/13.93 5/14.02 |
|POLY-3 PERCENT (g) | 0.0% 13.3% 7.9% 0.0% 7.2% 35.7% |
|TERMINAL (d) | 0/14 (0%) 2/15 (13%) 1/12 (8%) 0/14 (0%) 1/13 (8%) 5/11 (46%) |
|FIRST INCIDENCE | --- 192 (T) 192 (T) --- 192 (T) 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.251 P=0.469 (e) P=0.485 P=0.012 * |
|POLY 3 | P=0.003 ** P=0.245 P=0.479 (e) P=0.497 P=0.016 * |
|POLY 1.5 | P=0.003 ** P=0.241 P=0.485 (e) P=0.498 P=0.017 * |
|POLY 6 | P=0.002 ** P=0.247 P=0.474 (e) P=0.495 P=0.013 * |
|LOGISTIC REGRESSION| (e) P=0.251 P=0.469 (e) P=0.485 P=0.012 * |
|COCH-ARM / FISHERS | P=0.004 ** P=0.241 P=0.500 (e) P=0.500 P=0.021 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 2/15 (13%) 0/15 (0%) 0/15 (0%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 2/12.32 0/14.27 0/14.59 3/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 16.2% 0.0% 0.0% 21.5% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 2/12 (17%) 0/14 (0%) 0/14 (0%) 3/12 (25%) |
|FIRST INCIDENCE | --- --- 193 (T) --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.022 * (e) P=0.188 (e) (e) P=0.079 |
|POLY 3 | P=0.022 * (e) P=0.188 (e) (e) P=0.092 |
|POLY 1.5 | P=0.024 * (e) P=0.197 (e) (e) P=0.097 |
|POLY 6 | P=0.021 * (e) P=0.184 (e) (e) P=0.087 |
|LOGISTIC REGRESSION| (e) (e) P=0.188 (e) (e) P=0.079 |
|COCH-ARM / FISHERS | P=0.032 * (e) P=0.241 (e) (e) P=0.112 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/15 (20%) 6/15 (40%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) |
|POLY-3 RATE (b) | 3/14.15 6/15.00 0/12.73 0/14.33 0/13.93 3/14.02 |
|POLY-3 PERCENT (g) | 21.2% 40.0% 0.0% 0.0% 0.0% 21.4% |
|TERMINAL (d) | 3/14 (21%) 6/15 (40%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 3/11 (27%) |
|FIRST INCIDENCE | 192 (T) 192 (T) --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.525N P=0.252 P=0.143N P=0.115N P=0.128N P=0.551 |
|POLY 3 | P=0.371N P=0.246 P=0.125N P=0.103N P=0.108N P=0.668 |
|POLY 1.5 | P=0.379N P=0.237 P=0.119N P=0.103N P=0.107N P=0.669N |
|POLY 6 | P=0.369N P=0.251 P=0.130N P=0.104N P=0.109N P=0.650 |
|LOGISTIC REGRESSION| P=0.525N P=0.252 (e) (e) (e) P=0.551 |
|COCH-ARM / FISHERS | P=0.411N P=0.213 P=0.112N P=0.112N P=0.112N P=0.674N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/15 (27%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 4/15.00 0/14.85 0/12.32 0/14.27 0/14.59 1/13.93 |
|POLY-3 PERCENT (g) | 26.7% 0.0% 0.0% 0.0% 0.0% 7.2% |
|TERMINAL (d) | 4/15 (27%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 1/12 (8%) |
|FIRST INCIDENCE | 193 (T) --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.347N P=0.065N P=0.086N P=0.065N P=0.065N P=0.240N |
|POLY 3 | P=0.267N P=0.046N* P=0.073N P=0.051N P=0.048N* P=0.186N |
|POLY 1.5 | P=0.274N P=0.046N* P=0.066N P=0.049N* P=0.047N* P=0.177N |
|POLY 6 | P=0.262N P=0.047N* P=0.077N P=0.053N P=0.051N P=0.197N |
|LOGISTIC REGRESSION| P=0.347N (e) (e) (e) (e) P=0.240N |
|COCH-ARM / FISHERS | P=0.313N P=0.050N P=0.050N P=0.050N P=0.050N P=0.165N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Regeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 1/15 (7%) 5/15 (33%) 4/15 (27%) 4/15 (27%) 0/15 (0%) |
|POLY-3 RATE (b) | 2/14.15 1/15.00 5/12.73 4/14.33 4/13.93 0/14.02 |
|POLY-3 PERCENT (g) | 14.1% 6.7% 39.3% 27.9% 28.7% 0.0% |
|TERMINAL (d) | 2/14 (14%) 1/15 (7%) 5/12 (42%) 4/14 (29%) 4/13 (31%) 0/11 (0%) |
|FIRST INCIDENCE | 192 (T) 192 (T) 192 (T) 192 (T) 192 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.245N P=0.475N P=0.135 P=0.326 P=0.289 P=0.290N |
|POLY 3 | P=0.174N P=0.479N P=0.147 P=0.332 P=0.318 P=0.233N |
|POLY 1.5 | P=0.163N P=0.485N P=0.160 P=0.333 P=0.321 P=0.230N |
|POLY 6 | P=0.196N P=0.476N P=0.138 P=0.329 P=0.314 P=0.241N |
|LOGISTIC REGRESSION| P=0.245N P=0.475N P=0.135 P=0.326 P=0.289 (e) |
|COCH-ARM / FISHERS | P=0.162N P=0.500N P=0.195 P=0.326 P=0.326 P=0.241N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Regeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/15.00 1/14.85 0/12.32 0/14.27 2/14.59 1/13.93 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 0.0% 0.0% 13.7% 7.2% |
|TERMINAL (d) | 0/15 (0%) 1/14 (7%) 0/12 (0%) 0/14 (0%) 2/14 (14%) 1/12 (8%) |
|FIRST INCIDENCE | --- 193 (T) --- --- 193 (T) 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.186 P=0.486 (e) (e) P=0.221 P=0.455 |
|POLY 3 | P=0.212 P=0.498 (e) (e) P=0.225 P=0.485 |
|POLY 1.5 | P=0.218 P=0.499 (e) (e) P=0.228 P=0.491 |
|POLY 6 | P=0.204 P=0.496 (e) (e) P=0.221 P=0.479 |
|LOGISTIC REGRESSION| (e) P=0.486 (e) (e) P=0.221 P=0.455 |
|COCH-ARM / FISHERS | P=0.219 P=0.500 (e) (e) P=0.241 P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 6/15 (40%) |
|POLY-3 RATE (b) | 1/15.00 0/15.00 1/12.73 0/14.33 0/13.93 6/14.02 |
|POLY-3 PERCENT (g) | 6.7% 0.0% 7.9% 0.0% 0.0% 42.8% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 1/12 (8%) 0/14 (0%) 0/13 (0%) 6/11 (55%) |
|FIRST INCIDENCE | 101 --- 192 (T) --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.500N P=0.727 P=0.500N P=0.514N P=0.024 * |
|POLY 3 | P<0.001 ** P=0.500N P=0.723 P=0.509N P=0.515N P=0.025 * |
|POLY 1.5 | P<0.001 ** P=0.500N P=0.734 P=0.506N P=0.510N P=0.029 * |
|POLY 6 | P<0.001 ** P=0.500N P=0.715 P=0.512N P=0.518N P=0.020 * |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.691N (e) P=0.421N P=0.032 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500N P=0.759N P=0.500N P=0.500N P=0.040 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 6/15 (40%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 1/12.32 0/14.27 0/14.59 6/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.1% 0.0% 0.0% 43.1% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 1/12 (8%) 0/14 (0%) 0/14 (0%) 6/12 (50%) |
|FIRST INCIDENCE | --- --- 193 (T) --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.455 (e) (e) P=0.005 ** |
|POLY 3 | P<0.001 ** (e) P=0.461 (e) (e) P=0.003 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.470 (e) (e) P=0.004 ** |
|POLY 6 | P<0.001 ** (e) P=0.457 (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) P=0.455 (e) (e) P=0.005 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 (e) (e) P=0.008 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 5/15 (33%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 0/12.73 0/14.33 0/13.93 5/14.02 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 35.7% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 5/11 (46%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.012 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.016 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.017 * |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.013 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.012 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.021 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 1/12.32 0/14.27 0/14.59 1/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.1% 0.0% 0.0% 7.2% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 1/12 (8%) 0/14 (0%) 0/14 (0%) 1/12 (8%) |
|FIRST INCIDENCE | --- --- 193 (T) --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.289 (e) P=0.455 (e) (e) P=0.455 |
|POLY 3 | P=0.294 (e) P=0.461 (e) (e) P=0.485 |
|POLY 1.5 | P=0.301 (e) P=0.470 (e) (e) P=0.491 |
|POLY 6 | P=0.288 (e) P=0.457 (e) (e) P=0.479 |
|LOGISTIC REGRESSION| (e) (e) P=0.455 (e) (e) P=0.455 |
|COCH-ARM / FISHERS | P=0.316 (e) P=0.500 (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 9
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/15 (47%) 10/15 (67%) 8/15 (53%) 8/15 (53%) 7/15 (47%) 8/15 (53%) |
|POLY-3 RATE (b) | 7/14.15 10/15.00 8/13.60 8/14.33 7/13.93 8/14.02 |
|POLY-3 PERCENT (g) | 49.5% 66.7% 58.8% 55.9% 50.2% 57.1% |
|TERMINAL (d) | 7/14 (50%) 10/15 (67%) 7/12 (58%) 8/14 (57%) 7/13 (54%) 8/11 (73%) |
|FIRST INCIDENCE | 192 (T) 192 (T) 95 192 (T) 192 (T) 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.340 P=0.300 P=0.344 P=0.500 P=0.572 P=0.234 |
|POLY 3 | P=0.499N P=0.290 P=0.457 P=0.514 P=0.629 P=0.490 |
|POLY 1.5 | P=0.476N P=0.272 P=0.469 P=0.514 P=0.633 P=0.505 |
|POLY 6 | P=0.547N P=0.299 P=0.441 P=0.507 P=0.621 P=0.448 |
|LOGISTIC REGRESSION| P=0.469N P=0.300 P=0.440 P=0.500 P=0.572 P=0.234 |
|COCH-ARM / FISHERS | P=0.469N P=0.231 P=0.500 P=0.500 P=0.642N P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/15 (100%) 14/15 (93%) 13/15 (87%) 13/15 (87%) 14/15 (93%) 8/15 (53%) |
|POLY-3 RATE (b) | 15/15.00 14/15.00 13/13.07 13/14.27 14/14.59 8/13.93 |
|POLY-3 PERCENT (g) | 100.0% 93.3% 99.5% 91.1% 96.0% 57.5% |
|TERMINAL (d) | 15/15 (100%) 13/14 (93%) 12/12 (100%) 13/14 (93%) 14/14 (100%) 8/12 (67%) |
|FIRST INCIDENCE | 193 (T) 183 122 193 (T) 193 (T) 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002N** P=0.753N P=0.471 P=0.486N P=1.000N P=0.033N* |
|POLY 3 | P<0.001N** P=0.500N P=1.000N P=0.386N P=0.748N P=0.003N** |
|POLY 1.5 | P<0.001N** P=0.500N P=0.988N P=0.312N P=0.614N P=0.002N** |
|POLY 6 | P<0.001N** P=0.500N P=1.000N P=0.458N P=0.964N P=0.004N** |
|LOGISTIC REGRESSION| P<0.001N** (e) (e) P=0.486N P=1.000N P=0.033N* |
|COCH-ARM / FISHERS | P<0.001N** P=0.500N P=0.241N P=0.241N P=0.500N P=0.003N** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 10
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 0/12.73 0/14.33 0/13.93 1/14.02 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 7.1% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 1/11 (9%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.082 (e) (e) (e) (e) P=0.452 |
|POLY 3 | P=0.106 (e) (e) (e) (e) P=0.498 |
|POLY 1.5 | P=0.107 (e) (e) (e) (e) P=0.501 |
|POLY 6 | P=0.103 (e) (e) (e) (e) P=0.491 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.452 |
|COCH-ARM / FISHERS | P=0.105 (e) (e) (e) (e) P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 0/12.32 0/14.27 0/14.59 2/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 14.4% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 2/12 (17%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** (e) (e) (e) (e) P=0.188 |
|POLY 3 | P=0.009 ** (e) (e) (e) (e) P=0.214 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.221 |
|POLY 6 | P=0.009 ** (e) (e) (e) (e) P=0.208 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.188 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 11
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 2/15 (13%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/14.15 2/15.00 0/12.73 0/14.33 0/13.93 0/14.02 |
|POLY-3 PERCENT (g) | 0.0% 13.3% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 2/15 (13%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 0/11 (0%) |
|FIRST INCIDENCE | --- 192 (T) --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.317N P=0.251 (e) (e) (e) (e) |
|POLY 3 | P=0.260N P=0.245 (e) (e) (e) (e) |
|POLY 1.5 | P=0.266N P=0.241 (e) (e) (e) (e) |
|POLY 6 | P=0.256N P=0.247 (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.251 (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.286N P=0.241 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/15 (80%) 15/15 (100%) 12/15 (80%) 13/15 (87%) 14/15 (93%) 4/15 (27%) |
|POLY-3 RATE (b) | 12/15.00 15/15.00 12/12.32 13/14.27 14/15.00 4/13.93 |
|POLY-3 PERCENT (g) | 80.0% 100.0% 97.4% 91.1% 93.3% 28.7% |
|TERMINAL (d) | 12/15 (80%) 14/14 (100%) 12/12 (100%) 13/14 (93%) 13/14 (93%) 4/12 (33%) |
|FIRST INCIDENCE | 193 (T) 183 193 (T) 193 (T) 162 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.068 P=0.157 P=0.324 P=0.192 P=0.022N* |
|POLY 3 | P<0.001N** P=0.106 P=0.207 P=0.371 P=0.298 P=0.003N** |
|POLY 1.5 | P<0.001N** P=0.106 P=0.317 P=0.417 P=0.298 P=0.003N** |
|POLY 6 | P<0.001N** P=0.106 P=0.163 P=0.336 P=0.298 P=0.005N** |
|LOGISTIC REGRESSION| P<0.001N** (e) P=0.157 P=0.324 (e) P=0.022N* |
|COCH-ARM / FISHERS | P<0.001N** P=0.112 P=0.674N P=0.500 P=0.299 P=0.005N** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 12
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 2/15 (13%) 2/15 (13%) 0/15 (0%) 1/15 (7%) 1/15 (7%) |
|POLY-3 RATE (b) | 2/15.00 2/15.00 2/12.73 0/14.33 1/13.93 1/14.02 |
|POLY-3 PERCENT (g) | 13.3% 13.3% 15.7% 0.0% 7.2% 7.1% |
|TERMINAL (d) | 1/14 (7%) 2/15 (13%) 2/12 (17%) 0/14 (0%) 1/13 (8%) 1/11 (9%) |
|FIRST INCIDENCE | 101 192 (T) 192 (T) --- 192 (T) 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.379N P=0.678N P=0.641 P=0.240N P=0.525N P=0.556N |
|POLY 3 | P=0.325N P=0.698 P=0.637 P=0.242N P=0.526N P=0.524N |
|POLY 1.5 | P=0.319N P=0.698 P=0.655 P=0.238N P=0.518N P=0.513N |
|POLY 6 | P=0.334N P=0.698 P=0.624 P=0.246N P=0.532N P=0.540N |
|LOGISTIC REGRESSION| P=0.317N P=0.678N P=0.662N P=0.284N P=0.479N P=0.612N |
|COCH-ARM / FISHERS | P=0.310N P=0.701N P=0.701N P=0.241N P=0.500N P=0.500N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/15 (27%) 2/15 (13%) 1/15 (7%) 2/15 (13%) 1/15 (7%) 1/15 (7%) |
|POLY-3 RATE (b) | 4/15.00 2/14.85 1/12.32 2/14.27 1/14.59 1/13.93 |
|POLY-3 PERCENT (g) | 26.7% 13.5% 8.1% 14.0% 6.9% 7.2% |
|TERMINAL (d) | 4/15 (27%) 2/14 (14%) 1/12 (8%) 2/14 (14%) 1/14 (7%) 1/12 (8%) |
|FIRST INCIDENCE | 193 (T) 193 (T) 193 (T) 193 (T) 193 (T) 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.198N P=0.360N P=0.240N P=0.360N P=0.189N P=0.240N |
|POLY 3 | P=0.155N P=0.332N P=0.230N P=0.352N P=0.171N P=0.186N |
|POLY 1.5 | P=0.154N P=0.330N P=0.214N P=0.343N P=0.168N P=0.177N |
|POLY 6 | P=0.159N P=0.336N P=0.238N P=0.359N P=0.177N P=0.197N |
|LOGISTIC REGRESSION| P=0.198N P=0.360N P=0.240N P=0.360N P=0.189N P=0.240N |
|COCH-ARM / FISHERS | P=0.162N P=0.326N P=0.165N P=0.326N P=0.165N P=0.165N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 13
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 2/15 (13%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/14 (14%) |
|POLY-3 RATE (b) | 0/14.15 2/15.00 0/12.73 0/14.33 0/13.93 2/13.02 |
|POLY-3 PERCENT (g) | 0.0% 13.3% 0.0% 0.0% 0.0% 15.4% |
|TERMINAL (d) | 0/14 (0%) 2/15 (13%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- 192 (T) --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.123 P=0.251 (e) (e) (e) P=0.164 |
|POLY 3 | P=0.183 P=0.245 (e) (e) (e) P=0.211 |
|POLY 1.5 | P=0.181 P=0.241 (e) (e) (e) P=0.215 |
|POLY 6 | P=0.181 P=0.247 (e) (e) (e) P=0.202 |
|LOGISTIC REGRESSION| (e) P=0.251 (e) (e) (e) P=0.164 |
|COCH-ARM / FISHERS | P=0.176 P=0.241 (e) (e) (e) P=0.224 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 1/12.32 0/14.27 0/14.59 0/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.1% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 1/12 (8%) 0/14 (0%) 0/14 (0%) 0/12 (0%) |
|FIRST INCIDENCE | --- --- 193 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.581N (e) P=0.455 (e) (e) (e) |
|POLY 3 | P=0.585N (e) P=0.461 (e) (e) (e) |
|POLY 1.5 | P=0.581N (e) P=0.470 (e) (e) (e) |
|POLY 6 | P=0.587N (e) P=0.457 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.455 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.561N (e) P=0.500 (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 14
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 0/14 (0%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 0/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) 0/13 (0%) 2/12 (17%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 0/10.32 0/9.27 0/12.59 2/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 18.3% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/12 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007 ** (e) (e) (e) (e) P=0.190 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.226 |
|POLY 1.5 | P=0.008 ** (e) (e) (e) (e) P=0.235 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.217 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.190 |
|COCH-ARM / FISHERS | P=0.010 * (e) (e) (e) (e) P=0.261 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 15
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 4/14 (29%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 4/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 30.4% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 4/11 (36%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.044 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.051 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.053 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.047 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.044 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.057 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) 0/13 (0%) 2/12 (17%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 0/10.32 0/9.27 0/12.59 2/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 18.3% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/12 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007 ** (e) (e) (e) (e) P=0.190 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.226 |
|POLY 1.5 | P=0.008 ** (e) (e) (e) (e) P=0.235 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.217 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.190 |
|COCH-ARM / FISHERS | P=0.010 * (e) (e) (e) (e) P=0.261 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 16
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 3/14 (21%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 3/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 22.8% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 3/11 (27%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.098 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.118 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.120 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.112 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.098 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.124 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) 0/13 (0%) 0/12 (0%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 0/10.32 0/9.27 0/12.59 0/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/12 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 17
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 2/13 (15%) |
|POLY-3 RATE (b) | 0/14.15 0/14.00 0/12.73 0/14.33 0/13.82 2/12.03 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 16.6% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** (e) (e) (e) (e) P=0.164 |
|POLY 3 | P=0.006 ** (e) (e) (e) (e) P=0.193 |
|POLY 1.5 | P=0.006 ** (e) (e) (e) (e) P=0.197 |
|POLY 6 | P=0.006 ** (e) (e) (e) (e) P=0.184 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.164 |
|COCH-ARM / FISHERS | P=0.007 ** (e) (e) (e) (e) P=0.206 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 6/15 (40%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 1/12.32 0/14.27 0/14.59 6/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.1% 0.0% 0.0% 43.1% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 1/12 (8%) 0/14 (0%) 0/14 (0%) 6/12 (50%) |
|FIRST INCIDENCE | --- --- 193 (T) --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.455 (e) (e) P=0.005 ** |
|POLY 3 | P<0.001 ** (e) P=0.461 (e) (e) P=0.003 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.470 (e) (e) P=0.004 ** |
|POLY 6 | P<0.001 ** (e) P=0.457 (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) P=0.455 (e) (e) P=0.005 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 (e) (e) P=0.008 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 18
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/14 (7%) 1/15 (7%) 0/15 (0%) 1/14 (7%) 1/13 (8%) |
|POLY-3 RATE (b) | 0/14.15 1/14.00 1/13.18 0/14.33 1/14.00 1/12.03 |
|POLY-3 PERCENT (g) | 0.0% 7.1% 7.6% 0.0% 7.1% 8.3% |
|TERMINAL (d) | 0/14 (0%) 1/14 (7%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 1/10 (10%) |
|FIRST INCIDENCE | --- 192 (T) 157 --- 180 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.376 P=0.500 P=0.485 (e) P=0.500 P=0.433 |
|POLY 3 | P=0.371 P=0.498 P=0.486 (e) P=0.498 P=0.468 |
|POLY 1.5 | P=0.378 P=0.495 P=0.489 (e) P=0.495 P=0.471 |
|POLY 6 | P=0.356 P=0.500 P=0.485 (e) P=0.500 P=0.459 |
|LOGISTIC REGRESSION| P=0.359 P=0.500 P=0.557 (e) P=0.448 P=0.433 |
|COCH-ARM / FISHERS | P=0.376 P=0.483 P=0.500 (e) P=0.483 P=0.464 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 3/15 (20%) 3/15 (20%) 0/15 (0%) 3/15 (20%) 3/15 (20%) |
|POLY-3 RATE (b) | 1/15.00 3/14.85 3/13.29 0/14.27 3/15.00 3/13.93 |
|POLY-3 PERCENT (g) | 6.7% 20.2% 22.6% 0.0% 20.0% 21.5% |
|TERMINAL (d) | 1/15 (7%) 3/14 (21%) 2/12 (17%) 0/14 (0%) 2/14 (14%) 3/12 (25%) |
|FIRST INCIDENCE | 193 (T) 193 (T) 63 --- 162 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.245 P=0.273 P=0.245 P=0.514N P=0.285 P=0.220 |
|POLY 3 | P=0.272 P=0.295 P=0.254 P=0.510N P=0.298 P=0.270 |
|POLY 1.5 | P=0.282 P=0.296 P=0.264 P=0.507N P=0.298 P=0.281 |
|POLY 6 | P=0.261 P=0.291 P=0.248 P=0.513N P=0.298 P=0.259 |
|LOGISTIC REGRESSION| P=0.287 P=0.273 P=0.448 (e) (e) P=0.220 |
|COCH-ARM / FISHERS | P=0.295 P=0.299 P=0.299 P=0.500N P=0.299 P=0.299 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 19
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 4/13 (31%) |
|POLY-3 RATE (b) | 0/14.15 0/14.00 0/12.73 0/14.33 0/13.82 4/12.03 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 33.3% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 4/10 (40%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.023 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.025 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.027 * |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.022 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.023 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.035 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 1/12.32 0/14.27 0/14.59 1/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.1% 0.0% 0.0% 7.2% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 1/12 (8%) 0/14 (0%) 0/14 (0%) 1/12 (8%) |
|FIRST INCIDENCE | --- --- 193 (T) --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.289 (e) P=0.455 (e) (e) P=0.455 |
|POLY 3 | P=0.294 (e) P=0.461 (e) (e) P=0.485 |
|POLY 1.5 | P=0.301 (e) P=0.470 (e) (e) P=0.491 |
|POLY 6 | P=0.288 (e) P=0.457 (e) (e) P=0.479 |
|LOGISTIC REGRESSION| (e) (e) P=0.455 (e) (e) P=0.455 |
|COCH-ARM / FISHERS | P=0.316 (e) P=0.500 (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 20
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 1/13 (8%) |
|POLY-3 RATE (b) | 0/14.15 0/14.00 0/12.73 0/14.33 0/13.82 1/12.03 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 8.3% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 1/10 (10%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.075 (e) (e) (e) (e) P=0.433 |
|POLY 3 | P=0.091 (e) (e) (e) (e) P=0.468 |
|POLY 1.5 | P=0.092 (e) (e) (e) (e) P=0.471 |
|POLY 6 | P=0.088 (e) (e) (e) (e) P=0.459 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.433 |
|COCH-ARM / FISHERS | P=0.091 (e) (e) (e) (e) P=0.464 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 1/12.32 0/14.27 0/14.59 2/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.1% 0.0% 0.0% 14.4% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 1/12 (8%) 0/14 (0%) 0/14 (0%) 2/12 (17%) |
|FIRST INCIDENCE | --- --- 193 (T) --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.047 * (e) P=0.455 (e) (e) P=0.188 |
|POLY 3 | P=0.053 (e) P=0.461 (e) (e) P=0.214 |
|POLY 1.5 | P=0.055 (e) P=0.470 (e) (e) P=0.221 |
|POLY 6 | P=0.051 (e) P=0.457 (e) (e) P=0.208 |
|LOGISTIC REGRESSION| (e) (e) P=0.455 (e) (e) P=0.188 |
|COCH-ARM / FISHERS | P=0.060 (e) P=0.500 (e) (e) P=0.241 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 21
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) |
|POLY-3 RATE (b) | 0/14.15 0/14.00 0/11.73 0/14.33 0/13.93 0/11.44 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 4/15 (27%) |
|POLY-3 RATE (b) | 0/15.00 0/14.00 0/12.07 0/14.27 0/14.59 4/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 28.7% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 4/12 (33%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.033 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.036 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.039 * |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.033 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.033 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.050 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 22
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 1/12 (8%) |
|POLY-3 RATE (b) | 0/14.15 0/14.00 0/11.73 0/14.33 0/13.93 1/11.44 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 8.7% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 0/11 (0%) 0/14 (0%) 0/13 (0%) 1/10 (10%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.077 (e) (e) (e) (e) P=0.433 |
|POLY 3 | P=0.086 (e) (e) (e) (e) P=0.457 |
|POLY 1.5 | P=0.086 (e) (e) (e) (e) P=0.458 |
|POLY 6 | P=0.085 (e) (e) (e) (e) P=0.453 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.433 |
|COCH-ARM / FISHERS | P=0.085 (e) (e) (e) (e) P=0.444 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/15.00 0/14.00 0/12.07 0/14.27 0/14.59 2/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 14.4% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 2/12 (17%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** (e) (e) (e) (e) P=0.188 |
|POLY 3 | P=0.010 * (e) (e) (e) (e) P=0.214 |
|POLY 1.5 | P=0.010 * (e) (e) (e) (e) P=0.221 |
|POLY 6 | P=0.010 * (e) (e) (e) (e) P=0.208 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.188 |
|COCH-ARM / FISHERS | P=0.012 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 23
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Inguinal |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 0/14 (0%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 0/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Inguinal |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) 0/13 (0%) 2/12 (17%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 0/10.32 0/9.27 0/12.59 2/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 18.3% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/12 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007 ** (e) (e) (e) (e) P=0.190 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.226 |
|POLY 1.5 | P=0.008 ** (e) (e) (e) (e) P=0.235 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.217 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.190 |
|COCH-ARM / FISHERS | P=0.010 * (e) (e) (e) (e) P=0.261 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 24
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Inguinal |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 0/14 (0%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 0/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Inguinal |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) 0/13 (0%) 2/12 (17%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 0/10.32 0/9.27 0/12.59 2/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 18.3% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/12 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007 ** (e) (e) (e) (e) P=0.190 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.226 |
|POLY 1.5 | P=0.008 ** (e) (e) (e) (e) P=0.235 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.217 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.190 |
|COCH-ARM / FISHERS | P=0.010 * (e) (e) (e) (e) P=0.261 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 25
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 1/14 (7%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 1/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 7.6% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 1/11 (9%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.093 (e) (e) (e) (e) P=0.483 |
|POLY 3 | P=0.110 (e) (e) (e) (e) P=0.516 |
|POLY 1.5 | P=0.111 (e) (e) (e) (e) P=0.518 |
|POLY 6 | P=0.108 (e) (e) (e) (e) P=0.510 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.483 |
|COCH-ARM / FISHERS | P=0.108 (e) (e) (e) (e) P=0.519 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) 0/13 (0%) 5/12 (42%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 0/10.32 0/9.27 0/12.59 5/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 45.8% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/12 (0%) 5/9 (56%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.011 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.010 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.012 * |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.008 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.011 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.024 * |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 26
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 3/14 (21%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 3/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 22.8% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 3/11 (27%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.098 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.118 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.120 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.112 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.098 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.124 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 1/13 (8%) 0/10 (0%) 0/13 (0%) 2/12 (17%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 1/10.32 0/9.27 0/12.59 2/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 9.7% 0.0% 0.0% 18.3% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 1/10 (10%) 0/9 (0%) 0/12 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- 193 (T) --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.042 * (e) P=0.481 (e) (e) P=0.190 |
|POLY 3 | P=0.050 (e) P=0.487 (e) (e) P=0.226 |
|POLY 1.5 | P=0.052 (e) P=0.498 (e) (e) P=0.235 |
|POLY 6 | P=0.048 * (e) P=0.482 (e) (e) P=0.217 |
|LOGISTIC REGRESSION| (e) (e) P=0.481 (e) (e) P=0.190 |
|COCH-ARM / FISHERS | P=0.059 (e) P=0.542 (e) (e) P=0.261 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 27
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 3/14 (21%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 3/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 22.8% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 3/11 (27%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.098 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.118 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.120 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.112 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.098 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.124 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) 0/13 (0%) 2/12 (17%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 0/10.32 0/9.27 0/12.59 2/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 18.3% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/12 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007 ** (e) (e) (e) (e) P=0.190 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.226 |
|POLY 1.5 | P=0.008 ** (e) (e) (e) (e) P=0.235 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.217 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.190 |
|COCH-ARM / FISHERS | P=0.010 * (e) (e) (e) (e) P=0.261 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 28
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/13 (0%) 0/13 (0%) 0/14 (0%) 0/15 (0%) 0/14 (0%) 2/14 (14%) |
|POLY-3 RATE (b) | 0/12.15 0/13.00 0/11.73 0/14.33 0/12.93 2/13.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 15.2% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/11 (0%) 0/14 (0%) 0/12 (0%) 2/11 (18%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** (e) (e) (e) (e) P=0.216 |
|POLY 3 | P=0.009 ** (e) (e) (e) (e) P=0.249 |
|POLY 1.5 | P=0.010 * (e) (e) (e) (e) P=0.251 |
|POLY 6 | P=0.009 ** (e) (e) (e) (e) P=0.242 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.216 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.259 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/10 (0%) 0/13 (0%) 0/12 (0%) |
|POLY-3 RATE (b) | 0/11.00 0/13.85 0/10.32 0/9.27 0/12.59 0/10.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/11 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/12 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 29
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 1/15 (7%) 1/15 (7%) 1/14 (7%) 1/15 (7%) 2/15 (13%) |
|POLY-3 RATE (b) | 2/14.15 1/15.00 1/12.73 1/13.33 1/13.93 2/14.02 |
|POLY-3 PERCENT (g) | 14.1% 6.7% 7.9% 7.5% 7.2% 14.3% |
|TERMINAL (d) | 2/14 (14%) 1/15 (7%) 1/12 (8%) 1/13 (8%) 1/13 (8%) 2/11 (18%) |
|FIRST INCIDENCE | 192 (T) 192 (T) 192 (T) 192 (T) 192 (T) 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.363 P=0.475N P=0.555N P=0.527N P=0.527N P=0.610 |
|POLY 3 | P=0.455 P=0.479N P=0.538N P=0.521N P=0.505N P=0.696 |
|POLY 1.5 | P=0.461 P=0.485N P=0.527N P=0.521N P=0.504N P=0.697N |
|POLY 6 | P=0.442 P=0.476N P=0.546N P=0.524N P=0.508N P=0.683 |
|LOGISTIC REGRESSION| P=0.363 P=0.475N P=0.555N P=0.527N P=0.527N P=0.610 |
|COCH-ARM / FISHERS | P=0.458 P=0.500N P=0.500N P=0.527N P=0.500N P=0.701N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 2/15 (13%) 1/15 (7%) 2/15 (13%) 2/15 (13%) |
|POLY-3 RATE (b) | 1/15.00 0/14.85 2/12.32 1/14.27 2/14.59 2/13.93 |
|POLY-3 PERCENT (g) | 6.7% 0.0% 16.2% 7.0% 13.7% 14.4% |
|TERMINAL (d) | 1/15 (7%) 0/14 (0%) 2/12 (17%) 1/14 (7%) 2/14 (14%) 2/12 (17%) |
|FIRST INCIDENCE | 193 (T) --- 193 (T) 193 (T) 193 (T) 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.189 P=0.514N P=0.420 P=0.749 P=0.475 P=0.420 |
|POLY 3 | P=0.216 P=0.502N P=0.431 P=0.749 P=0.490 P=0.474 |
|POLY 1.5 | P=0.226 P=0.501N P=0.446 P=0.753 P=0.495 P=0.483 |
|POLY 6 | P=0.207 P=0.504N P=0.423 P=0.746 P=0.484 P=0.463 |
|LOGISTIC REGRESSION| P=0.189 (e) P=0.420 P=0.749 P=0.475 P=0.420 |
|COCH-ARM / FISHERS | P=0.236 P=0.500N P=0.500 P=0.759N P=0.500 P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 30
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Epidermis, Skin, Site of Application |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 6/15 (40%) 14/15 (93%) 15/15 (100%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 0/12.73 6/14.33 14/14.82 15/15.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 41.9% 94.4% 100.0% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/12 (0%) 6/14 (43%) 13/13 (100%) 11/11 (100%) |
|FIRST INCIDENCE | --- --- --- 192 (T) 92 161 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.012 * P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.005 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.005 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.005 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.012 * P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.008 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Epidermis, Skin, Site of Application |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 4/15 (27%) 15/15 (100%) 15/15 (100%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 1/12.32 4/14.27 15/15.00 15/15.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.1% 28.0% 100.0% 100.0% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 1/12 (8%) 4/14 (29%) 14/14 (100%) 12/12 (100%) |
|FIRST INCIDENCE | --- --- 193 (T) 193 (T) 162 118 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.455 P=0.048 * P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.461 P=0.039 * P<0.001N** P<0.001N** |
|POLY 1.5 | P<0.001 ** (e) P=0.470 P=0.041 * P<0.001N** P<0.001N** |
|POLY 6 | P<0.001 ** (e) P=0.457 P=0.038 * P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.455 P=0.048 * (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 P=0.050 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 31
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Epidermis, Skin, Site of Application |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 1/15 (7%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 1/12.73 0/14.33 1/13.93 0/14.02 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 7.9% 0.0% 7.2% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 1/12 (8%) 0/14 (0%) 1/13 (8%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- 192 (T) --- 192 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.683 (e) P=0.469 (e) P=0.485 (e) |
|POLY 3 | P=0.696 (e) P=0.479 (e) P=0.497 (e) |
|POLY 1.5 | P=0.691N (e) P=0.485 (e) P=0.498 (e) |
|POLY 6 | P=0.679 (e) P=0.474 (e) P=0.495 (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.469 (e) P=0.485 (e) |
|COCH-ARM / FISHERS | P=0.684N (e) P=0.500 (e) P=0.500 (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Epidermis, Skin, Site of Application |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 1/15 (7%) 8/15 (53%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 0/12.32 1/14.27 1/14.59 8/14.70 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 7.0% 6.9% 54.4% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 1/14 (7%) 1/14 (7%) 7/12 (58%) |
|FIRST INCIDENCE | --- --- --- 193 (T) 193 (T) 118 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.486 P=0.486 P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.490 P=0.494 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.493 P=0.497 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.487 P=0.491 P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.486 P=0.486 P=0.003 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.500 P=0.500 P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 32
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Skin, Site of Application |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 15/15 (100%) 14/15 (93%) 12/15 (80%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 1/13.18 15/15.00 14/14.82 12/15.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 7.6% 100.0% 94.4% 80.0% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/12 (0%) 14/14 (100%) 13/13 (100%) 8/11 (73%) |
|FIRST INCIDENCE | --- --- 157 132 92 161 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.485 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.486 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.489 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P=0.485 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.557 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Skin, Site of Application |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 7/15 (47%) 14/15 (93%) 13/15 (87%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 1/12.32 7/14.27 14/15.00 13/14.23 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.1% 49.1% 93.3% 91.4% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 1/12 (8%) 7/14 (50%) 13/14 (93%) 11/12 (92%) |
|FIRST INCIDENCE | --- --- 193 (T) 193 (T) 162 176 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.455 P=0.004 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.461 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.470 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P=0.457 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.455 P=0.004 ** (e) P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 P=0.003 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 33
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Skin, Site of Application |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 1/15 (7%) 9/15 (60%) 12/15 (80%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 1/12.73 1/15.00 9/13.93 12/14.59 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 7.9% 6.7% 64.6% 82.3% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 1/12 (8%) 0/14 (0%) 9/13 (69%) 9/11 (82%) |
|FIRST INCIDENCE | --- --- 192 (T) 132 192 (T) 161 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.469 P=0.514 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.479 P=0.512 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.485 P=0.508 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P=0.474 P=0.513 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.469 P=0.324 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 P=0.500 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Skin, Site of Application |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) 14/15 (93%) 12/15 (80%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 0/12.32 3/14.27 14/15.00 12/13.99 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 21.0% 93.3% 85.8% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 3/14 (21%) 13/14 (93%) 11/12 (92%) |
|FIRST INCIDENCE | --- --- --- 193 (T) 162 189 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.104 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.097 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.100 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.094 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.104 (e) P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.112 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 34
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 1/15 (7%) 4/15 (27%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 1/13.18 0/14.33 1/14.11 4/15.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 7.6% 0.0% 7.1% 26.7% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- 157 --- 180 161 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** (e) P=0.485 (e) P=0.500 P=0.062 |
|POLY 3 | P<0.001 ** (e) P=0.486 (e) P=0.499 P=0.052 |
|POLY 1.5 | P<0.001 ** (e) P=0.489 (e) P=0.499 P=0.050 |
|POLY 6 | P<0.001 ** (e) P=0.485 (e) P=0.500 P=0.054 |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.557 (e) P=0.503 P=0.033 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 (e) P=0.500 P=0.050 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 3/15 (20%) 1/15 (7%) 2/15 (13%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/15.00 1/15.00 3/15.00 1/15.00 2/15.00 1/13.99 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 20.0% 6.7% 13.3% 7.2% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 1/14 (7%) 0/12 (0%) |
|FIRST INCIDENCE | --- 183 63 124 162 189 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.545 P=0.500 P=0.113 P=0.500 P=0.232 P=0.471 |
|POLY 3 | P=0.522 P=0.500 P=0.106 P=0.500 P=0.232 P=0.486 |
|POLY 1.5 | P=0.536 P=0.500 P=0.106 P=0.500 P=0.232 P=0.491 |
|POLY 6 | P=0.507 P=0.500 P=0.106 P=0.500 P=0.232 P=0.481 |
|LOGISTIC REGRESSION| P=0.610 (e) (e) (e) (e) P=0.506 |
|COCH-ARM / FISHERS | P=0.562 P=0.500 P=0.112 P=0.500 P=0.241 P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 35
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 4/15 (27%) 1/15 (7%) 2/15 (13%) 6/15 (40%) 8/15 (53%) |
|POLY-3 RATE (b) | 1/15.00 4/15.00 1/12.73 2/14.33 6/13.93 8/14.02 |
|POLY-3 PERCENT (g) | 6.7% 26.7% 7.9% 14.0% 43.1% 57.1% |
|TERMINAL (d) | 0/14 (0%) 4/15 (27%) 1/12 (8%) 2/14 (14%) 6/13 (46%) 8/11 (73%) |
|FIRST INCIDENCE | 101 192 (T) 192 (T) 192 (T) 192 (T) 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.192 P=0.727 P=0.500 P=0.039 * P=0.003 ** |
|POLY 3 | P<0.001 ** P=0.163 P=0.723 P=0.484 P=0.025 * P=0.002 ** |
|POLY 1.5 | P<0.001 ** P=0.163 P=0.734 P=0.490 P=0.027 * P=0.002 ** |
|POLY 6 | P<0.001 ** P=0.163 P=0.715 P=0.478 P=0.023 * P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.192 P=0.691N P=0.422 P=0.042 * P=0.007 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.165 P=0.759N P=0.500 P=0.040 * P=0.007 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/15 (47%) 13/15 (87%) 9/15 (60%) 6/15 (40%) 8/15 (53%) 10/15 (67%) |
|POLY-3 RATE (b) | 7/15.00 13/14.85 9/12.32 6/14.27 8/14.59 10/14.70 |
|POLY-3 PERCENT (g) | 46.7% 87.5% 73.0% 42.1% 54.8% 68.0% |
|TERMINAL (d) | 7/15 (47%) 13/14 (93%) 9/12 (75%) 6/14 (43%) 8/14 (57%) 9/12 (75%) |
|FIRST INCIDENCE | 193 (T) 193 (T) 193 (T) 193 (T) 193 (T) 118 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.274 P=0.012 * P=0.141 P=0.565N P=0.425 P=0.086 |
|POLY 3 | P=0.526 P=0.016 * P=0.159 P=0.547N P=0.470 P=0.211 |
|POLY 1.5 | P=0.526 P=0.018 * P=0.197 P=0.531N P=0.483 P=0.222 |
|POLY 6 | P=0.506 P=0.014 * P=0.143 P=0.560N P=0.452 P=0.194 |
|LOGISTIC REGRESSION| P=0.460 P=0.012 * P=0.141 P=0.565N P=0.425 P=0.268 |
|COCH-ARM / FISHERS | P=0.482 P=0.025 * P=0.358 P=0.500N P=0.500 P=0.231 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 36
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 1/15 (7%) 1/15 (7%) 1/15 (7%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/14.15 1/15.00 1/13.67 1/14.33 1/13.93 0/14.02 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 7.3% 7.0% 7.2% 0.0% |
|TERMINAL (d) | 0/14 (0%) 1/15 (7%) 0/12 (0%) 1/14 (7%) 1/13 (8%) 0/11 (0%) |
|FIRST INCIDENCE | --- 192 (T) 74 192 (T) 192 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.484N P=0.514 P=0.500 P=0.500 P=0.485 (e) |
|POLY 3 | P=0.446N P=0.512 P=0.493 P=0.503 P=0.497 (e) |
|POLY 1.5 | P=0.441N P=0.508 P=0.496 P=0.503 P=0.498 (e) |
|POLY 6 | P=0.457N P=0.513 P=0.490 P=0.501 P=0.495 (e) |
|LOGISTIC REGRESSION| P=0.485N P=0.514 (e) P=0.500 P=0.485 (e) |
|COCH-ARM / FISHERS | P=0.438N P=0.500 P=0.500 P=0.500 P=0.500 (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 2/15 (13%) 2/15 (13%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 2/15.00 2/14.85 2/12.32 0/14.27 0/14.59 0/13.93 |
|POLY-3 PERCENT (g) | 13.3% 13.5% 16.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/15 (13%) 2/14 (14%) 2/12 (17%) 0/14 (0%) 0/14 (0%) 0/12 (0%) |
|FIRST INCIDENCE | 193 (T) 193 (T) 193 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.062N P=0.676 P=0.617 P=0.251N P=0.251N P=0.286N |
|POLY 3 | P=0.053N P=0.695 P=0.624 P=0.243N P=0.238N P=0.249N |
|POLY 1.5 | P=0.052N P=0.696 P=0.642 P=0.239N P=0.235N P=0.242N |
|POLY 6 | P=0.054N P=0.692 P=0.616 P=0.246N P=0.242N P=0.256N |
|LOGISTIC REGRESSION| P=0.062N P=0.676 P=0.617 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.053N P=0.701N P=0.701N P=0.241N P=0.241N P=0.241N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 37
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 0/12.73 0/14.33 0/13.93 0/14.02 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 0/12.32 0/14.27 0/14.59 2/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 14.4% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 2/12 (17%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** (e) (e) (e) (e) P=0.188 |
|POLY 3 | P=0.009 ** (e) (e) (e) (e) P=0.214 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.221 |
|POLY 6 | P=0.009 ** (e) (e) (e) (e) P=0.208 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.188 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 38
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 1/15 (7%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 1/13.60 0/14.33 1/13.93 3/14.59 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 7.4% 0.0% 7.2% 20.6% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/12 (0%) 0/14 (0%) 1/13 (8%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- 95 --- 192 (T) 161 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009 ** (e) P=0.486 (e) P=0.485 P=0.115 |
|POLY 3 | P=0.008 ** (e) P=0.492 (e) P=0.497 P=0.111 |
|POLY 1.5 | P=0.008 ** (e) P=0.494 (e) P=0.498 P=0.111 |
|POLY 6 | P=0.008 ** (e) P=0.489 (e) P=0.495 P=0.110 |
|LOGISTIC REGRESSION| P=0.004 ** (e) P=0.772 (e) P=0.485 P=0.092 |
|COCH-ARM / FISHERS | P=0.009 ** (e) P=0.500 (e) P=0.500 P=0.112 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 0/12.32 0/14.27 0/14.59 0/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 0/12 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 39
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 2/14.15 0/15.00 1/13.18 0/14.33 0/13.93 1/14.02 |
|POLY-3 PERCENT (g) | 14.1% 0.0% 7.6% 0.0% 0.0% 7.1% |
|TERMINAL (d) | 2/14 (14%) 0/15 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 1/11 (9%) |
|FIRST INCIDENCE | 192 (T) --- 157 --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.593N P=0.221N P=0.545N P=0.236N P=0.252N P=0.587N |
|POLY 3 | P=0.563N P=0.218N P=0.525N P=0.228N P=0.234N P=0.503N |
|POLY 1.5 | P=0.559N P=0.222N P=0.520N P=0.228N P=0.233N P=0.498N |
|POLY 6 | P=0.565N P=0.216N P=0.526N P=0.230N P=0.236N P=0.516N |
|LOGISTIC REGRESSION| P=0.552N (e) P=0.499N (e) (e) P=0.587N |
|COCH-ARM / FISHERS | P=0.550N P=0.241N P=0.500N P=0.241N P=0.241N P=0.500N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 40
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes: Unilateral, Germinal Epithelium |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/15 (27%) 0/15 (0%) 3/15 (20%) 1/15 (7%) 1/15 (7%) 2/15 (13%) |
|POLY-3 RATE (b) | 4/14.15 0/15.00 3/14.06 1/14.33 1/13.93 2/14.02 |
|POLY-3 PERCENT (g) | 28.3% 0.0% 21.3% 7.0% 7.2% 14.3% |
|TERMINAL (d) | 4/14 (29%) 0/15 (0%) 1/12 (8%) 1/14 (7%) 1/13 (8%) 2/11 (18%) |
|FIRST INCIDENCE | 192 (T) --- 95 192 (T) 192 (T) 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.520N P=0.048N* P=0.573N P=0.166N P=0.189N P=0.449N |
|POLY 3 | P=0.462N P=0.038N* P=0.504N P=0.157N P=0.166N P=0.330N |
|POLY 1.5 | P=0.451N P=0.040N* P=0.506N P=0.157N P=0.164N P=0.324N |
|POLY 6 | P=0.475N P=0.037N* P=0.501N P=0.159N P=0.168N P=0.348N |
|LOGISTIC REGRESSION| P=0.446N (e) P=0.449N P=0.166N P=0.189N P=0.449N |
|COCH-ARM / FISHERS | P=0.434N P=0.050N P=0.500N P=0.165N P=0.165N P=0.326N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes: Unilateral, Germinal Epithelium |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 41
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 1/14 (7%) 0/15 (0%) 2/15 (13%) 5/15 (33%) |
|POLY-3 RATE (b) | 1/14.15 0/15.00 1/12.18 0/14.33 2/15.00 5/15.00 |
|POLY-3 PERCENT (g) | 7.1% 0.0% 8.2% 0.0% 13.3% 33.3% |
|TERMINAL (d) | 1/14 (7%) 0/15 (0%) 0/11 (0%) 0/14 (0%) 0/13 (0%) 1/11 (9%) |
|FIRST INCIDENCE | 192 (T) --- 157 --- 92 161 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** P=0.486N P=0.725 P=0.500N P=0.491 P=0.086 |
|POLY 3 | P<0.001 ** P=0.488N P=0.727 P=0.497N P=0.521 P=0.094 |
|POLY 1.5 | P<0.001 ** P=0.492N P=0.731 P=0.497N P=0.515 P=0.089 |
|POLY 6 | P<0.001 ** P=0.487N P=0.726 P=0.499N P=0.524 P=0.096 |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.774 (e) P=0.526 P=0.071 |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500N P=0.741 P=0.500N P=0.500 P=0.084 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 3/15 (20%) 2/15 (13%) 2/15 (13%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/15.00 1/15.00 3/15.00 2/15.00 2/15.00 3/15.00 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 20.0% 13.3% 13.3% 20.0% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 1/14 (7%) 1/14 (7%) 0/12 (0%) |
|FIRST INCIDENCE | --- 183 63 124 162 118 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.146 P=0.500 P=0.113 P=0.232 P=0.232 P=0.112 |
|POLY 3 | P=0.146 P=0.500 P=0.106 P=0.232 P=0.232 P=0.106 |
|POLY 1.5 | P=0.146 P=0.500 P=0.106 P=0.232 P=0.232 P=0.106 |
|POLY 6 | P=0.146 P=0.500 P=0.106 P=0.232 P=0.232 P=0.106 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.143 P=0.500 P=0.112 P=0.241 P=0.241 P=0.112 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 42
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus: Thymocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 0/11.73 0/14.33 0/13.93 1/14.43 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 6.9% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/11 (0%) 0/14 (0%) 0/13 (0%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 161 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.117 (e) (e) (e) (e) P=0.514 |
|POLY 3 | P=0.111 (e) (e) (e) (e) P=0.504 |
|POLY 1.5 | P=0.111 (e) (e) (e) (e) P=0.504 |
|POLY 6 | P=0.110 (e) (e) (e) (e) P=0.500 |
|LOGISTIC REGRESSION| P=0.078 (e) (e) (e) (e) P=0.410 |
|COCH-ARM / FISHERS | P=0.107 (e) (e) (e) (e) P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus: Thymocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 2/15 (13%) 1/15 (7%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 2/14.04 1/15.00 0/14.59 1/13.99 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 14.3% 6.7% 0.0% 7.2% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 0/12 (0%) |
|FIRST INCIDENCE | --- --- 63 124 --- 189 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.518 (e) P=0.224 P=0.500 (e) P=0.471 |
|POLY 3 | P=0.497 (e) P=0.216 P=0.500 (e) P=0.486 |
|POLY 1.5 | P=0.506 (e) P=0.219 P=0.500 (e) P=0.491 |
|POLY 6 | P=0.489 (e) P=0.216 P=0.500 (e) P=0.481 |
|LOGISTIC REGRESSION| P=0.406 (e) P=0.829 (e) (e) P=0.506 |
|COCH-ARM / FISHERS | P=0.525 (e) P=0.241 P=0.500 (e) P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 43
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/14.15 0/15.00 0/12.73 0/14.33 0/13.93 1/14.02 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 7.1% |
|TERMINAL (d) | 0/14 (0%) 0/15 (0%) 0/12 (0%) 0/14 (0%) 0/13 (0%) 1/11 (9%) |
|FIRST INCIDENCE | --- --- --- --- --- 192 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.082 (e) (e) (e) (e) P=0.452 |
|POLY 3 | P=0.106 (e) (e) (e) (e) P=0.498 |
|POLY 1.5 | P=0.107 (e) (e) (e) (e) P=0.501 |
|POLY 6 | P=0.103 (e) (e) (e) (e) P=0.491 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.452 |
|COCH-ARM / FISHERS | P=0.105 (e) (e) (e) (e) P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/15.00 0/14.85 0/12.32 0/14.27 0/14.59 2/13.93 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 14.4% |
|TERMINAL (d) | 0/15 (0%) 0/14 (0%) 0/12 (0%) 0/14 (0%) 0/14 (0%) 2/12 (17%) |
|FIRST INCIDENCE | --- --- --- --- --- 193 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** (e) (e) (e) (e) P=0.188 |
|POLY 3 | P=0.009 ** (e) (e) (e) (e) P=0.214 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.221 |
|POLY 6 | P=0.009 ** (e) (e) (e) (e) P=0.208 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.188 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88133 TEST: 06 Page 44
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - TRIMETHYLOLPROPANE TRIACRYLATE
(TMPTA)
Terminal Sacrifice at 28 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/15 (67%) 11/15 (73%) 7/15 (47%) 8/15 (53%) 8/15 (53%) 9/15 (60%) |
|POLY-3 RATE (b) | 10/15.00 11/14.85 7/12.32 8/14.27 8/14.59 9/13.99 |
|POLY-3 PERCENT (g) | 66.7% 74.1% 56.8% 56.1% 54.8% 64.4% |
|TERMINAL (d) | 10/15 (67%) 11/14 (79%) 7/12 (58%) 8/14 (57%) 8/14 (57%) 8/12 (67%) |
|FIRST INCIDENCE | 193 (T) 193 (T) 193 (T) 193 (T) 193 (T) 189 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.493 P=0.384 P=0.483N P=0.443N P=0.443N P=0.489 |
|POLY 3 | P=0.428N P=0.484 P=0.449N P=0.419N P=0.391N P=0.600N |
|POLY 1.5 | P=0.411N P=0.492 P=0.394N P=0.397N P=0.376N P=0.563N |
|POLY 6 | P=0.456N P=0.470 P=0.476N P=0.437N P=0.412N P=0.637N |
|LOGISTIC REGRESSION| P=0.566 P=0.384 P=0.483N P=0.443N P=0.443N P=0.596 |
|COCH-ARM / FISHERS | P=0.425N P=0.500 P=0.231N P=0.355N P=0.355N P=0.500N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).