TDMS Study 88133-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) DATE: 07/12/02
EXPERIMENT: 88133 TEST: 06 TIME: 08:53:21
TEST TYPE: SUBCHRON 26-WEEK PAGE: 1
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 88133B
PATHOLOGIST: TOFT, JOHN CAS: 15625-89-5
------------------------------------------------------------------------------------------------------------------------------------
Final#2
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 MG/KG
INCLUDE 002 0 MG/KG
INCLUDE 003 0.75 MG/KG
INCLUDE 004 0.75 MG/KG
INCLUDE 005 1.5 MG/KG
INCLUDE 006 1.5 MG/KG
INCLUDE 007 3 MG/KG
INCLUDE 008 3 MG/KG
INCLUDE 009 6 MG/KG
INCLUDE 010 6 MG/KG
INCLUDE 011 12 MG/KG
INCLUDE 012 12 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) DATE: 07/12/02
EXPERIMENT: 88133 TEST: 06 TIME: 08:53:21
TEST TYPE: SUBCHRON 26-WEEK
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 88133B
PATHOLOGIST: TOFT, JOHN CAS: 15625-89-5
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 192 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 101 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.75 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.5 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 74 95 157 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 192 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 132 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 92 180 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 161 161 182 191 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 192 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 20 40 60 80 100 120 140 160 180 192 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 93.3 93.3 93.3 93.3 93.3 |
| | |
| | |
|0.75 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|MG/KG | |
| | |
|1.5 | 100.0 100.0 100.0 93.3 86.7 86.7 86.7 86.7 80.0 80.0 |
|MG/KG | |
| | |
|3 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 93.3 93.3 |
| | |
| | |
|6 MG/KG | 100.0 100.0 100.0 100.0 93.3 93.3 93.3 93.3 93.3 86.7 |
| | |
| | |
|12 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 86.7 73.3 |
| | |
| | |
==================================================================================
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 192 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| MG/KG MG/KG |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 93.3% 100.0% 80.0% 93.3% 86.7% 73.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.111 P=1.000N P=0.567 P=1.000N P=0.984 P=0.357 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 101.0 . 108.7 132.0 136.0 173.8 |
|NATURAL DEATHS (C) | ( . ) ( . ) (24.9) ( . ) (44.0) ( 7.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 185.9 192.0 175.3 188.0 184.5 187.1 |
|(STANDARD ERROR) | ( 6.1) ( 0.0) ( 9.9) ( 4.0) ( 6.7) ( 2.8) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 193 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.75 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 183 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.5 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 63 63 122 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 193 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 124 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 162 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 118 176 189 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 193 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 20 40 60 80 100 120 140 160 180 193 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
|0.75 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 |
|MG/KG | |
| | |
|1.5 | 100.0 100.0 100.0 86.7 86.7 86.7 80.0 80.0 80.0 80.0 |
|MG/KG | |
| | |
|3 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 93.3 93.3 |
| | |
| | |
|6 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 |
| | |
| | |
|12 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 93.3 80.0 |
| | |
| | |
==================================================================================
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 193 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| MG/KG MG/KG |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 93.3% 80.0% 93.3% 93.3% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.305 P=1.000 P=0.226 P=1.000 P=1.000 P=0.224 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . 183.0 82.7 124.0 162.0 161.0 |
|NATURAL DEATHS (C) | ( . ) ( . ) (19.7) ( . ) ( . ) (21.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 193.0 192.3 170.9 188.4 190.9 186.6 |
|(STANDARD ERROR) | ( 0.0) ( 0.7) (12.3) ( 4.6) ( 2.1) ( 5.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
0.75 MG/KG = 2
1.5 MG/KG = 3
3 MG/KG = 4
6 MG/KG = 5
12 MG/KG = 6
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
P 100.00 + 1 3 5 1 4 6 2
E |
R |
C |
E 93.33 + 3 3 1 4 5 1
N |
T |
|
S 86.67 + 3 3 5 5
U |
R |
V |
I 80.00 + 3 6 3
V |
A |
L |
73.33 + 6
|
---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+--
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
WEEK
NOTE: 10 obs hidden.
TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
0.75 MG/KG = 2
1.5 MG/KG = 3
3 MG/KG = 4
6 MG/KG = 5
12 MG/KG = 6
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
P |
E |
R 100.00 + 1 3 6 4 5 2 1
C |
E |
N |
T 93.33 + 6 4 5 6 2 2
|
S |
U |
R 86.67 + 3 3 6 6
V |
I |
V |
A 80.00 + 3 6 3
L |
---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+--
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
WEEK
NOTE: 8 obs hidden.