TDMS Study 88133-06 Pathology Tables
NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 Final#3 Facility: Battelle Columbus Laboratory Chemical CAS #: 15625-89-5 Lock Date: 06/16/99 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 002 0 MG/KG Include 001 0 MG/KG Include 004 0.75 MG/KG Include 003 0.75 MG/KG Include 006 1.5 MG/KG Include 005 1.5 MG/KG Include 008 3 MG/KG Include 007 3 MG/KG Include 010 6 MG/KG Include 009 6 MG/KG Include 012 12 MG/KG Include 011 12 MG/KG Note: Animals arranged according to days on test Page 1 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0 MG/KG | 7| 7| 7| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 8| 8| | L | | 2| 3| 8| 1| 2| 3| 5| 1| 4| 5| 6| 7| 9| 0| 4| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Salivary Glands | + | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X | 3 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | Odontogenic Tumor | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0 MG/KG | 7| 7| 7| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 8| 8| | L | | 2| 3| 8| 1| 2| 3| 5| 1| 4| 5| 6| 7| 9| 0| 4| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + M + + + + + M M M + + + + | 11 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolar/Bronchiolar Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0 MG/KG | 7| 7| 7| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 8| 8| | L | | 2| 3| 8| 1| 2| 3| 5| 1| 4| 5| 6| 7| 9| 0| 4| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0.75 | 8| 9| 9| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L | MG/KG | 6| 2| 6| 9| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X | 4 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Tooth | + + + + | 4 | Odontogenic Tumor | X X X X | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0.75 | 8| 9| 9| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L | MG/KG | 6| 2| 6| 9| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Vagina | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + + + + + M + + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 1 | Osteosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0.75 | 8| 9| 9| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L | MG/KG | 6| 2| 6| 9| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 6| 6| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1.5 | 0| 0| 1| 0| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L | MG/KG | 4| 7| 0| 2| 2| 5| 1| 3| 5| 6| 8| 9| 1| 3| 4| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X | 3 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | Odontogenic Tumor | X X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 6| 6| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1.5 | 0| 0| 1| 0| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L | MG/KG | 4| 7| 0| 2| 2| 5| 1| 3| 5| 6| 8| 9| 1| 3| 4| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + + + + + M + + M + + + + + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Skin, Site of Application, Squamous | | | Cell Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 3 MG/KG | 2| 1| 1| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 2| 6| 8| 0| 1| 7| 9| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 3 MG/KG | 2| 1| 1| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 2| 6| 8| 0| 1| 7| 9| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node | + M M + + + + M + + M + + + M | 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | Skin, Site of Application, Squamous | | | Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolar/Bronchiolar Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 3 MG/KG | 2| 1| 1| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 2| 6| 8| 0| 1| 7| 9| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 6 MG/KG | 4| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 4| 4| 4| | L | | 5| 1| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 3 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X | 4 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | Odontogenic Tumor | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 6 MG/KG | 4| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 4| 4| 4| | L | | 5| 1| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Uterus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + M + + + + + + + + M + + + + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Skin, Site of Application, Squamous | | | Cell Carcinoma | X | 1 | Skin, Site of Application, Squamous | | | Cell Papilloma | X X X X X X | 6 | Skin, Site of Application, Squamous | | | Cell Papilloma, Multiple | X X X X X | 5 | Vulva, Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 6 MG/KG | 4| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 4| 4| 4| | L | | 5| 1| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 1| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 8| 6| 9| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 12 MG/KG | 5| 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 6| | L | | 3| 5| 8| 7| 8| 9| 1| 6| 0| 2| 4| 6| 7| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Salivary Glands | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X X X | 6 | Squamous Cell Papilloma, Multiple | X X X | 3 | |__________________________________________________________________________|____________| Tooth | + + | 2 | Odontogenic Tumor | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 1| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 8| 6| 9| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 12 MG/KG | 5| 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 6| | L | | 3| 5| 8| 7| 8| 9| 1| 6| 0| 2| 4| 6| 7| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Uterus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + + M M + + + + + + M + + + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Skin, Site of Application, Squamous | | | Cell Carcinoma | X | 1 | Skin, Site of Application, Squamous | | | Cell Papilloma, Multiple | X X X X X X X X X X X X X X X | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 1| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 8| 6| 9| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 12 MG/KG | 5| 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 6| | L | | 3| 5| 8| 7| 8| 9| 1| 6| 0| 2| 4| 6| 7| 9| 0| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X X | 2 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 8| 8| 8| 8| 9| 9| 9| 9| | L | | 1| 2| 4| 5| 6| 1| 3| 3| 7| 8| 9| 0| 2| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X | 3 | Squamous Cell Papilloma, Multiple | X X | 2 | |__________________________________________________________________________|____________| Tooth | + | 1 | Odontogenic Tumor | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Preputial Gland | + | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 8| 8| 8| 8| 9| 9| 9| 9| | L | | 1| 2| 4| 5| 6| 1| 3| 3| 7| 8| 9| 0| 2| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + M + M + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/KG | 8| 8| 8| 8| 8| 9| 9| 8| 8| 8| 8| 9| 9| 9| 9| | L | | 1| 2| 4| 5| 6| 1| 3| 3| 7| 8| 9| 0| 2| 4| 5| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.75 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| | L | MG/KG | 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X X X | 4 | Squamous Cell Papilloma, Multiple | X X X | 3 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | Odontogenic Tumor | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.75 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| | L | MG/KG | 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | M + + + + + + + M + + + + + + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 5| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.5 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 1| 1| 2| 2| 2| | L | MG/KG | 3| 2| 6| 1| 5| 7| 8| 1| 2| 5| 4| 9| 0| 3| 4| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Salivary Glands | + | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | Odontogenic Tumor | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 5| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.5 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 1| 1| 2| 2| 2| | L | MG/KG | 3| 2| 6| 1| 5| 7| 8| 1| 2| 5| 4| 9| 0| 3| 4| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + M + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + | 14 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 4| 5| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.5 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 1| 1| 2| 2| 2| | L | MG/KG | 3| 2| 6| 1| 5| 7| 8| 1| 2| 5| 4| 9| 0| 3| 4| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Urinary Bladder | + | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 3 MG/KG | 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 5| 6| 7| 8| 9| 0| 1| 3| 7| 9| 2| 4| 6| 8| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Salivary Glands | + | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X | 2 | Squamous Cell Papilloma, Multiple | X X | 2 | |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + + + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 3 MG/KG | 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 5| 6| 7| 8| 9| 0| 1| 3| 7| 9| 2| 4| 6| 8| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Skin, Site of Application, Squamous | | | Cell Papilloma | X X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 3 MG/KG | 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 5| 6| 7| 8| 9| 0| 1| 3| 7| 9| 2| 4| 6| 8| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 6 MG/KG | 5| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 5| 5| 5| | L | | 3| 3| 1| 2| 5| 7| 8| 9| 2| 5| 4| 6| 0| 1| 4| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Mesentery | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X | 2 | Squamous Cell Papilloma, Multiple | X | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | Odontogenic Tumor | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 6 MG/KG | 5| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 5| 5| 5| | L | | 3| 3| 1| 2| 5| 7| 8| 9| 2| 5| 4| 6| 0| 1| 4| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + M + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | I + + + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Skin, Site of Application, Squamous | | | Cell Papilloma, Multiple | X X X X X X X X X X X X | 12 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 6 MG/KG | 5| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 5| 5| 5| | L | | 3| 3| 1| 2| 5| 7| 8| 9| 2| 5| 4| 6| 0| 1| 4| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 1| 1| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 12 MG/KG | 5| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 7| 6| 6| | L | | 8| 6| 9| 7| 6| 7| 9| 1| 2| 4| 5| 8| 0| 0| 3| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Mesentery | + | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + | 2 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X | 2 | |__________________________________________________________________________|____________| Tooth | + | 1 | Odontogenic Tumor | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 1| 1| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 12 MG/KG | 5| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 7| 6| 6| | L | | 8| 6| 9| 7| 6| 7| 9| 1| 2| 4| 5| 8| 0| 0| 3| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Preputial Gland | + | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + M + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M M + + + + + + + + + + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + M + + + + M + + + + + + | 12 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Squamous Cell Papilloma | X X | 2 | Skin, Site of Application, Squamous | | | Cell Papilloma, Multiple | X X X X X X X X X X X X X | 13 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 88133-06 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: SUBCHRON 26-WEEK TRIMETHYLOLPROPANE TRIACRYLATE Date: 10/30/02 Route: SKIN APPLICATION Time: 10:09:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 1| 1| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 12 MG/KG | 5| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 7| 6| 6| | L | | 8| 6| 9| 7| 6| 7| 9| 1| 2| 4| 5| 8| 0| 0| 3| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + M + + + | 14 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + | 15 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------