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TDMS Study 89002-01 Pathology Tables

NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97
Route: DOSED FEED                                                                                                 Time: 08:26:51

                                                             28 DAY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  0000087-86-5

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:26:51  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      800 PPM      1600 PPM     3200 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                  1           
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            8           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (9)          
      Angiectasis                                                                             1 (10%)                               
      Hepatodiaphragmatic Nodule                       3 (30%)                   2 (20%)      2 (20%)      3 (30%)      2 (22%)     
      Hepatocyte, Degeneration                                                   1 (10%)      6 (60%)      8 (80%)      8 (89%)     
      Hepatocyte, Centrilobular, Hypertrophy                                                               1 (10%)      7 (78%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)         (10)         (9)          
      Cardiomyopathy                                                1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)         (10)         (10)         (10)         (10)         (9)          
      Inflammation, Chronic Active                                                            1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:26:51  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      800 PPM      1600 PPM     3200 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Degeneration                                                                                                      1 (11%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage, Acute                                                          1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)         (10)         (9)          
      Inflammation, Chronic Active                     1 (10%)                   1 (10%)                   1 (10%)      3 (33%)     
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Suppurative                        1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Mineralization                                  10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)     8 (89%)     
      Nephropathy, Chronic                             6 (60%)      3 (30%)      5 (50%)      3 (30%)      2 (20%)      3 (33%)     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:26:51  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      800 PPM      1600 PPM     3200 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                  1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            9           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Basophilic Focus                                                           1 (10%)                                            
      Hepatodiaphragmatic Nodule                       2 (20%)                   2 (20%)      1 (10%)                   1 (10%)     
      Hepatocyte, Degeneration                                                   4 (40%)      7 (70%)      9 (90%)     10 (100%)    
      Hepatocyte, Necrosis                             1 (10%)                                                                      
      Hepatocyte, Centrilobular, Hypertrophy                                                               3 (30%)      6 (60%)     
   Salivary Glands                                    (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                   2 (20%)      7 (70%)      6 (60%)      2 (20%)      1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                   1 (10%)                                                         
      Inflammation, Chronic Active                                                                                      3 (30%)     
   Prostate                                           (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation                                                                                         1 (10%)                  
      Inflammation, Chronic Active                                                                                      1 (10%)     
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:26:51  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      800 PPM      1600 PPM     3200 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Germinal Epithelium, Degeneration                                                                                10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                     3 (30%)                                1 (10%)      2 (20%)      4 (40%)     
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                    10 (100%)     1 (10%)      5 (50%)      3 (30%)      1 (10%)      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                                4 (40%)      2 (20%)      1 (10%)                               
      Nephropathy, Chronic                             7 (70%)      9 (90%)      5 (50%)      8 (80%)      7 (70%)      3 (30%)     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
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