TDMS Study 89002-01 Pathology Tables
NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:26:51
28 DAY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 0000087-86-5
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:26:51
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FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 800 PPM 1600 PPM 3200 PPM
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DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 1
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 10 8
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (9)
Angiectasis 1 (10%)
Hepatodiaphragmatic Nodule 3 (30%) 2 (20%) 2 (20%) 3 (30%) 2 (22%)
Hepatocyte, Degeneration 1 (10%) 6 (60%) 8 (80%) 8 (89%)
Hepatocyte, Centrilobular, Hypertrophy 1 (10%) 7 (78%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (9)
Cardiomyopathy 1 (10%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (10) (10) (10) (10) (10) (9)
Inflammation, Chronic Active 1 (10%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:26:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 800 PPM 1600 PPM 3200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Thymus (10) (10) (10) (10) (10) (9)
Degeneration 1 (11%)
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INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Hemorrhage, Acute 1 (10%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (9)
Inflammation, Chronic Active 1 (10%) 1 (10%) 1 (10%) 3 (33%)
Nose (10) (10) (10) (10) (10) (10)
Inflammation, Suppurative 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (9)
Mineralization 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 8 (89%)
Nephropathy, Chronic 6 (60%) 3 (30%) 5 (50%) 3 (30%) 2 (20%) 3 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:26:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 800 PPM 1600 PPM 3200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 10 10 10 10 10 9
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Basophilic Focus 1 (10%)
Hepatodiaphragmatic Nodule 2 (20%) 2 (20%) 1 (10%) 1 (10%)
Hepatocyte, Degeneration 4 (40%) 7 (70%) 9 (90%) 10 (100%)
Hepatocyte, Necrosis 1 (10%)
Hepatocyte, Centrilobular, Hypertrophy 3 (30%) 6 (60%)
Salivary Glands (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (10)
Cardiomyopathy 2 (20%) 7 (70%) 6 (60%) 2 (20%) 1 (10%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Preputial Gland (10) (10) (10) (10) (10) (10)
Hyperplasia 1 (10%)
Inflammation, Chronic Active 3 (30%)
Prostate (10) (10) (10) (10) (10) (10)
Inflammation 1 (10%)
Inflammation, Chronic Active 1 (10%)
Testes (10) (10) (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:26:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 800 PPM 1600 PPM 3200 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Germinal Epithelium, Degeneration 10 (100%)
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HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 3 (30%) 1 (10%) 2 (20%) 4 (40%)
Nose (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 10 (100%) 1 (10%) 5 (50%) 3 (30%) 1 (10%) 1 (10%)
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Mineralization 4 (40%) 2 (20%) 1 (10%)
Nephropathy, Chronic 7 (70%) 9 (90%) 5 (50%) 8 (80%) 7 (70%) 3 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
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