TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:28 27 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 87-86-5 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: All Treatment Groups: Include 002 0 PPM Include 010 1000 PPM Include 001 0 PPM Include 009 1000 PPM a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 1000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 Scheduled Sacrifice 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) Basophilic Focus 4 (40%) Hepatodiaphragmatic Nodule 3 (30%) Inflammation, Chronic 10 (100%) 10 (100%) Centrilobular, Hypertrophy 2 (20%) Hepatocyte, Necrosis 3 (30%) Hepatocyte, Centrilobular, Hypertrophy 6 (60%) Pancreas (10) (10) Acinus, Atrophy 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Cardiomyopathy, Chronic 2 (20%) 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Pituitary Gland (10) (10) Pars Distalis, Cyst 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (10) (10) Inflammation, Chronic Active 6 (60%) 2 (20%) Ovary (10) (10) Cyst 1 (10%) 2 (20%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 1000 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Inflammation, Chronic Active 7 (70%) 5 (50%) Nose (10) (10) Inflammation, Chronic Active 4 (40%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) Mineralization 10 (100%) 10 (100%) Nephropathy, Chronic 3 (30%) 3 (30%) Renal Tubule, Pigmentation 10 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 1000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 Scheduled Sacrifice 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) Basophilic Focus 1 (10%) 1 (10%) Hepatodiaphragmatic Nodule 1 (10%) Inflammation, Chronic 7 (70%) 5 (50%) Artery, Inflammation, Chronic 2 (20%) Bile Duct, Hyperplasia 2 (20%) Centrilobular, Hypertrophy 3 (30%) Hepatocyte, Hypertrophy 1 (10%) Hepatocyte, Vacuolization Cytoplasmic 8 (80%) Hepatocyte, Centrilobular, Hypertrophy 6 (60%) Pancreas (10) (10) Acinus, Atrophy 2 (20%) Acinus, Inflammation, Chronic Active 2 (20%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Cardiomyopathy, Chronic 9 (90%) 10 (100%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Pituitary Gland (10) (10) Pars Distalis, Hyperplasia 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 1000 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (10) (10) Atrophy 1 (10%) Inflammation, Chronic Active 1 (10%) Preputial Gland (10) (10) Inflammation, Chronic Active 10 (100%) 10 (100%) Prostate (10) (10) Inflammation, Chronic Active 5 (50%) 7 (70%) Testes (10) (10) Mineralization 1 (10%) Necrosis 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Inflammation, Chronic Active 7 (70%) 6 (60%) Nose (10) (10) Fungus 1 (10%) 1 (10%) Inflammation, Chronic Active 6 (60%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 1000 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) Mineralization 8 (80%) 9 (90%) Nephropathy, Chronic 10 (100%) 9 (90%) Renal Tubule, Pigmentation 10 (100%) Transitional Epithelium, Hyperplasia 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------