TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 Core Study Facility: Battelle Columbus Laboratory Chemical CAS #: 87-86-5 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 PPM Include 002 0 PPM Include 003 200 PPM Include 004 200 PPM Include 005 400 PPM Include 006 400 PPM Include 007 600 PPM Include 008 600 PPM a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 60 50 50 50 Early Deaths Moribund Sacrifice 15 12 12 17 Natural Death 7 5 4 5 Survivors Terminal Sacrifice 28 33 34 28 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) (50) Intestine Large, Rectum (50) (50) (50) (50) Intestine Small, Duodenum (50) (50) (50) (50) Intestine Small, Jejunum (50) (50) (50) (50) Carcinoma 1 (2%) Intestine Small, Ileum (50) (50) (50) (50) Liver (50) (50) (50) (50) Mesentery (8) (1) (5) (5) Carcinoma, Metastatic, Intestine Small, Jejunum 1 (20%) Schwannoma Malignant, Metastatic, Uterus 1 (13%) Oral Mucosa (1) (1) Pharyngeal, Squamous Cell Papilloma 1 (100%) Pancreas (50) (49) (50) (50) Carcinoma, Metastatic, Intestine Small, Jejunum 1 (2%) Salivary Glands (50) (49) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Stomach, Glandular (50) (50) (50) (50) Carcinoma, Metastatic, Intestine Small, Jejunum 1 (2%) Tongue (1) Squamous Cell Papilloma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) (50) Heart (50) (50) (50) (50) Carcinoma, Metastatic, Intestine Small, Jejunum 1 (2%) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Adenoma 1 (2%) Adrenal Medulla (50) (50) (50) (50) Pheochromocytoma Malignant 1 (2%) Pheochromocytoma Benign 3 (6%) 1 (2%) 1 (2%) Islets, Pancreatic (50) (49) (50) (50) Adenoma 1 (2%) Parathyroid Gland (46) (44) (41) (47) Adenoma 1 (2%) Pituitary Gland (50) (50) (50) (50) Pars Distalis, Adenoma 22 (44%) 20 (40%) 14 (28%) 15 (30%) Pars Distalis, Adenoma, Multiple 1 (2%) Pars Intermedia, Adenoma 1 (2%) 1 (2%) Thyroid Gland (50) (50) (50) (50) Bilateral, C-Cell, Adenoma 1 (2%) C-Cell, Adenoma 3 (6%) 3 (6%) 1 (2%) 3 (6%) C-Cell, Carcinoma 2 (4%) 1 (2%) 2 (4%) Follicular Cell, Adenoma 1 (2%) 1 (2%) Follicular Cell, Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) Abdominal, Paraganglioma 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (50) (48) (50) Adenoma 4 (8%) 1 (2%) 1 (2%) 2 (4%) Carcinoma 1 (2%) 1 (2%) 2 (4%) Bilateral, Adenoma 1 (2%) Bilateral, Carcinoma 1 (2%) Ovary (50) (50) (50) (50) Granulosa Cell Tumor Benign 1 (2%) 1 (2%) Leiomyosarcoma, Metastatic, Uterus 1 (2%) Thecoma Malignant 1 (2%) Uterus (50) (50) (50) (50) Leiomyosarcoma 1 (2%) Polyp Stromal 6 (12%) 6 (12%) 3 (6%) 4 (8%) Sarcoma Stromal 1 (2%) 1 (2%) Schwannoma Malignant, Metastatic, Uterus 1 (2%) Vagina (2) (1) Schwannoma Malignant, Metastatic, Uterus 1 (50%) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Lymph Node (35) (27) (26) (28) Deep Cervical, Carcinoma, Metastatic, Thyroid Gland 1 (4%) 1 (4%) Mediastinal, Carcinoma, Metastatic, Intestine Small, Jejunum 1 (4%) Pancreatic, Carcinoma, Metastatic, Intestine Small, Jejunum 1 (4%) Lymph Node, Mandibular (50) (49) (50) (50) Lymph Node, Mesenteric (50) (50) (50) (50) Spleen (50) (50) (50) (50) Thymus (48) (44) (48) (47) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Adenoma 1 (2%) 1 (2%) Carcinoma 1 (2%) 2 (4%) 2 (4%) Carcinoma, Multiple 1 (2%) Fibroadenoma 16 (32%) 17 (34%) 18 (36%) 11 (22%) Fibroadenoma, Multiple 9 (18%) 3 (6%) 1 (2%) 1 (2%) Skin (50) (50) (50) (50) Keratoacanthoma 1 (2%) Squamous Cell Papilloma 1 (2%) Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Vertebra, Fibrosarcoma 1 (2%) Skeletal Muscle (2) (1) Carcinoma, Metastatic, Intestine Small, Jejunum 1 (50%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Astrocytoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 2 (4%) Alveolar/Bronchiolar Carcinoma 1 (2%) Carcinoma, Metastatic, Intestine Small, Jejunum 1 (2%) Nose (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Ureter (1) Carcinoma 1 (100%) Urinary Bladder (50) (50) (49) (49) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Leukemia Mononuclear 15 (30%) 15 (30%) 15 (30%) 18 (36%) Lymphoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 45 43 42 43 Total Primary Neoplasms 93 77 69 69 Total Animals with Benign Neoplasms 37 37 27 30 Total Benign Neoplasms 70 56 42 45 Total Animals with Malignant Neoplasms 20 18 23 24 Total Malignant Neoplasms 23 21 27 24 Total Animals with Metastatic Neoplasms 1 1 2 1 Total Metastatic Neoplasm 3 1 9 1 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 60 50 50 50 Early Deaths Moribund Sacrifice 28 28 24 11 Natural Death 10 6 5 8 Survivors Natural Death 1 2 Terminal Sacrifice 11 16 21 29 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) (49) Intestine Large, Rectum (50) (50) (50) (49) Polyp Adenomatous 1 (2%) Intestine Large, Cecum (50) (50) (50) (50) Polyp Adenomatous 1 (2%) Intestine Small, Duodenum (50) (50) (50) (49) Intestine Small, Jejunum (49) (50) (50) (50) Intestine Small, Ileum (49) (50) (50) (49) Liver (50) (50) (50) (50) Fibrous Histiocytoma 1 (2%) Hepatocellular Carcinoma 1 (2%) Hepatocellular Adenoma 1 (2%) Osteosarcoma, Metastatic, Spleen 1 (2%) Mesentery (15) (12) (15) (11) Lipoma 1 (8%) Fat, Osteosarcoma, Metastatic, Spleen 1 (9%) Fat, Sarcoma 1 (7%) Oral Mucosa (1) (1) (1) Pharyngeal, Squamous Cell Papilloma 1 (100%) Pancreas (50) (50) (50) (48) Acinus, Adenoma 2 (4%) 1 (2%) Salivary Glands (50) (50) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Osteosarcoma, Metastatic, Spleen 1 (2%) Squamous Cell Carcinoma 1 (2%) Stomach, Glandular (50) (50) (50) (50) Osteosarcoma, Metastatic, Spleen 1 (2%) Tongue (1) (1) (1) Squamous Cell Carcinoma 1 (100%) Squamous Cell Papilloma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) (50) Heart (50) (50) (50) (50) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Adrenal Medulla (50) (50) (50) (50) Pheochromocytoma Malignant 1 (2%) 1 (2%) 3 (6%) 1 (2%) Pheochromocytoma Complex 1 (2%) 1 (2%) Pheochromocytoma Benign 7 (14%) 17 (34%) 17 (34%) 12 (24%) Bilateral, Pheochromocytoma Benign 7 (14%) 4 (8%) 3 (6%) 11 (22%) Islets, Pancreatic (50) (50) (50) (48) Adenoma 1 (2%) Carcinoma 1 (2%) Parathyroid Gland (47) (45) (47) (46) Adenoma 1 (2%) 1 (2%) 1 (2%) Pituitary Gland (50) (50) (49) (50) Pars Distalis, Adenoma 18 (36%) 16 (32%) 13 (27%) 13 (26%) Pars Distalis, Adenoma, Multiple 1 (2%) Pars Distalis, Carcinoma 1 (2%) Pars Intermedia, Adenoma 1 (2%) Thyroid Gland (50) (50) (50) (50) C-Cell, Adenoma 5 (10%) 8 (16%) 7 (14%) 6 (12%) C-Cell, Carcinoma 2 (4%) 2 (4%) 2 (4%) Follicular Cell, Adenoma 1 (2%) Follicular Cell, Carcinoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Fibrous Histiocytoma, Metastatic, Skin 1 (2%) Preputial Gland (50) (50) (50) (50) Adenoma 4 (8%) 3 (6%) 1 (2%) Carcinoma 1 (2%) 7 (14%) 1 (2%) Bilateral, Adenoma 1 (2%) Prostate (50) (50) (50) (49) Carcinoma 1 (2%) Seminal Vesicle (50) (50) (50) (49) Page 8 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont Testes (50) (50) (50) (50) Bilateral, Interstitial Cell, Adenoma 34 (68%) 35 (70%) 42 (84%) 42 (84%) Interstitial Cell, Adenoma 8 (16%) 12 (24%) 3 (6%) 4 (8%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) Lymph Node (34) (34) (35) (41) Deep Cervical, Carcinoma, Metastatic, Thyroid Gland 1 (2%) Mediastinal, Fibrous Histiocytoma, Metastatic, Liver 1 (3%) Mediastinal, Osteosarcoma, Metastatic, Spleen 1 (2%) Mediastinal, Sarcoma, Metastatic, Mesentery 1 (3%) Renal, Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (3%) Lymph Node, Mandibular (50) (50) (50) (50) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) Lymph Node, Mesenteric (50) (50) (50) (49) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) Fibrous Histiocytoma, Metastatic, Skin 1 (2%) Osteosarcoma, Metastatic, Spleen 1 (2%) Spleen (50) (50) (50) (50) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) Osteosarcoma 1 (2%) Thymus (49) (46) (49) (47) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) Thymoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (49) (47) (50) (49) Carcinoma 1 (2%) Fibroadenoma 5 (10%) 5 (11%) 4 (8%) 2 (4%) Skin (50) (50) (50) (50) Basal Cell Adenoma 1 (2%) Basal Cell Carcinoma 1 (2%) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) Keratoacanthoma 2 (4%) 1 (2%) 3 (6%) Squamous Cell Papilloma 2 (4%) 1 (2%) 3 (6%) Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) 2 (4%) 2 (4%) Subcutaneous Tissue, Fibroma, Multiple 1 (2%) Subcutaneous Tissue, Fibrosarcoma 2 (4%) 2 (4%) Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%) 1 (2%) Page 9 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Vertebra, Chordoma 1 (2%) Vertebra, Hemangiosarcoma 1 (2%) Skeletal Muscle (1) (1) Osteosarcoma, Metastatic, Spleen 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Astrocytoma Malignant 1 (2%) 1 (2%) Carcinoma, Metastatic, Pituitary Gland 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 2 (4%) Alveolar/Bronchiolar Carcinoma 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Chordoma, Metastatic, Bone 1 (2%) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) Fibrous Histiocytoma, Metastatic, Skin 1 (2%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (2%) Squamous Cell Carcinoma 1 (2%) Mediastinum, Hemangiosarcoma 1 (2%) Mediastinum, Squamous Cell Carcinoma, Metastatic, Lung 1 (2%) Nose (50) (50) (50) (50) Squamous Cell Carcinoma 1 (2%) 3 (6%) 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) (2) Adenoma 1 (50%) Carcinoma 1 (100%) 1 (50%) ____________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Fibrous Histiocytoma, Metastatic, Liver 1 (2%) Fibrous Histiocytoma, Metastatic, Skin 1 (2%) Renal Tubule, Adenoma 1 (2%) 1 (2%) Renal Tubule, Carcinoma 2 (4%) Urinary Bladder (48) (50) (50) (49) Transitional Epithelium, Papilloma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Leukemia Mononuclear 25 (50%) 26 (52%) 26 (52%) 23 (46%) Mesothelioma Malignant 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 11 NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 11:03:46 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 50 50 50 48 Total Primary Neoplasms 135 155 145 141 Total Animals with Benign Neoplasms 48 50 48 48 Total Benign Neoplasms 100 110 101 103 Total Animals with Malignant Neoplasms 32 37 36 32 Total Malignant Neoplasms 35 45 44 38 Total Animals with Metastatic Neoplasms 1 2 4 4 Total Metastatic Neoplasm 1 5 13 10 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------