TDMS Study 89002-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:47:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:47:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF PENTACHLOROPHENOL
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Degeneration Fatty
Hypertrophy
Adrenal Medulla Hyperplasia
Bone Marrow Hyperplasia
Heart Cardiomyopathy Chronic
Heart: Atrium Thrombosis
Kidney Nephropathy Chronic
Kidney: Renal Tubule Pigmentation
Liver Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Hepatodiaphragmatic Nodule
Inflammation Chronic
Liver: Bile Duct Hyperplasia
Liver: Hepatocyte Degeneration Cystic
Vacuolization Cytoplasmic
Lung: Alveolus Infiltration Cellular Histiocyte
Lymph Node, Mediastinal Pigmentation Hemosiderin
Mammary Gland Hyperplasia Cystic
Mesentery: Fat Necrosis
Nose Fungus
Inflammation Chronic
Nose: Respiratory Epithelium Hyperplasia
Metaplasia
Pancreas: Acinus Atrophy
Parathyroid Gland Hyperplasia
Pituitary Gland: Pars Distalis Cyst
Hyperplasia
Preputial Gland Hyperplasia
Inflammation Chronic
Prostate Inflammation Chronic
Skin: Epidermis Hyperkeratosis
Spleen Fibrosis
Hematopoietic Cell Proliferation
Stomach, Forestomach Inflammation Chronic
Stomach, Forestomach: Epithelium Hyperplasia
Ulcer
Testes: Interstitial Cell Hyperplasia
Thyroid Gland: C-Cell Hyperplasia
===============================================================
Female Rats
------------
Organ Morphology
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:47:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
----- ----------
Adrenal Cortex Degeneration Fatty
Hyperplasia
Hypertrophy
Bone Osteopetrosis
Bone Marrow Hyperplasia
Clitoral Gland Inflammation Chronic
Eye: Lens Cataract
Eye: Retina Atrophy
Heart Cardiomyopathy Chronic
Intestine Large, Colon Parasite Metazoan
Intestine Large, Rectum Parasite Metazoan
Liver Clear Cell Focus
Mixed Cell Focus
Liver: Hepatocyte Vacuolization Cytoplasmic
Lymph Node, Mediastinal Pigmentation Hemosiderin
Nose Fungus
Inflammation Chronic
Nose: Respiratory Epithelium Hyperplasia
Pituitary Gland: Pars Distalis Cyst
Thyroid Gland: C-Cell Hyperplasia
===============================================================
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Accessory Adrenal Cortical Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 4.6% |2.4% 4.7% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 2/31 (7%) |1/28 (4%) 2/33 (6%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 736 (T) 736 (T) |738 (T) 738 (T) --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.161 (e) P=0.612 P=0.463 |P=0.138N P=0.558 P=0.461N P=0.500N |
|POLY 3 | P=0.076 (e) P=0.504 P=0.272 |P=0.148N P=0.514 P=0.491N P=0.502N |
|POLY 1.5 | P=0.068 (e) P=0.502 P=0.256 |P=0.148N P=0.505 P=0.495N P=0.501N |
|POLY 6 | P=0.091 (e) P=0.509 P=0.299 |P=0.150N P=0.529 P=0.485N P=0.505N |
|LOGISTIC REGRESSION| (e) (e) P=0.612 P=0.463 |P=0.138N P=0.558 (e) (e) |
|COCH-ARM / FISHERS | P=0.059 (e) P=0.500 P=0.247 |P=0.149N P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |0/50 (0%) 4/50 (8%) 3/50 (6%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 2.7% 2.8% 2.6% 0.0% |0.0% 9.3% 7.0% 0.0% |
|TERMINAL (d) | 1/12 (8%) 1/16 (6%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 4/33 (12%) 3/34 (9%) 0/28 (0%) |
|FIRST INCIDENCE | 736 (T) 736 (T) 624 --- |--- 738 (T) 738 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.168N P=0.698N P=0.704N P=0.311N |P=0.496N P=0.085 P=0.157 (e) |
|POLY 3 | P=0.268N P=0.754 P=0.755N P=0.470N |P=0.506N P=0.065 P=0.126 (e) |
|POLY 1.5 | P=0.284N P=0.756 P=0.757N P=0.484N |P=0.502N P=0.062 P=0.123 (e) |
|POLY 6 | P=0.245N P=0.753 P=0.748N P=0.449N |P=0.518N P=0.071 P=0.132 (e) |
|LOGISTIC REGRESSION| P=0.259N P=0.698N P=0.759N (e) |(e) P=0.085 P=0.157 (e) |
|COCH-ARM / FISHERS | P=0.301N P=0.753N P=0.753N P=0.500N |P=0.500N P=0.059 P=0.121 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Fatty |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 28/50 (56%) 19/50 (38%) 16/50 (32%) 20/50 (40%) |9/50 (18%) 11/50 (22%) 17/50 (34%) 15/50 (30%) |
|POLY-3 ADJUSTED (b)| 63.2% 46.9% 38.1% 43.5% |21.2% 25.5% 37.7% 35.6% |
|TERMINAL (d) | 8/12 (67%) 6/16 (38%) 6/21 (29%) 12/31 (39%) |4/28 (14%) 10/33 (30%) 10/34 (29%) 11/28 (39%) |
|FIRST INCIDENCE | 396 507 443 518 |585 620 451 586 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.064N P=0.005N** P<0.001N** |P=0.049 * P=0.545 P=0.139 P=0.122 |
|POLY 3 | P=0.020N* P=0.087N P=0.012N* P=0.041N* |P=0.044 * P=0.417 P=0.071 P=0.107 |
|POLY 1.5 | P=0.030N* P=0.072N P=0.012N* P=0.059N |P=0.046 * P=0.403 P=0.062 P=0.114 |
|POLY 6 | P=0.011N* P=0.100N P=0.012N* P=0.023N* |P=0.038 * P=0.441 P=0.084 P=0.096 |
|LOGISTIC REGRESSION| P=0.037N* P=0.058N P=0.013N* P=0.080N |P=0.045 * P=0.442 P=0.060 P=0.112 |
|COCH-ARM / FISHERS | P=0.048N* P=0.054N P=0.013N* P=0.080N |P=0.049 * P=0.402 P=0.055 P=0.121 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 11/50 (22%) 13/50 (26%) 15/50 (30%) |7/50 (14%) 12/50 (24%) 23/50 (46%) 12/50 (24%) |
|POLY-3 ADJUSTED (b)| 32.2% 29.3% 33.1% 34.0% |17.0% 28.0% 51.6% 29.1% |
|TERMINAL (d) | 4/12 (33%) 7/16 (44%) 8/21 (38%) 12/31 (39%) |6/28 (21%) 12/33 (36%) 19/34 (56%) 10/28 (36%) |
|FIRST INCIDENCE | 564 524 605 619 |698 738 (T) 451 634 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.067N P=0.313N P=0.291N P=0.088N |P=0.027 * P=0.255 P=0.003 ** P=0.141 |
|POLY 3 | P=0.417 P=0.488N P=0.562 P=0.521 |P=0.027 * P=0.168 P<0.001 ** P=0.144 |
|POLY 1.5 | P=0.363 P=0.450N P=0.576 P=0.471 |P=0.031 * P=0.156 P<0.001 ** P=0.149 |
|POLY 6 | P=0.500 P=0.541N P=0.544 P=0.590 |P=0.022 * P=0.192 P<0.001 ** P=0.135 |
|LOGISTIC REGRESSION| P=0.499N P=0.441N P=0.567N P=0.582 |P=0.024 * P=0.255 P<0.001 ** P=0.120 |
|COCH-ARM / FISHERS | P=0.307 P=0.408N P=0.590N P=0.412 |P=0.037 * P=0.154 P<0.001 ** P=0.154 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 4/50 (8%) |1/50 (2%) 6/50 (12%) 8/50 (16%) 7/50 (14%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.7% 5.1% 9.2% |2.4% 14.0% 18.6% 17.2% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 4/31 (13%) |1/28 (4%) 6/33 (18%) 8/34 (24%) 7/28 (25%) |
|FIRST INCIDENCE | --- 619 443 736 (T) |738 (T) 738 (T) 738 (T) 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.068 P=0.489 P=0.244 P=0.238 |P=0.020 * P=0.085 P=0.033 * P=0.029 * |
|POLY 3 | P=0.028 * P=0.495 P=0.249 P=0.082 |P=0.024 * P=0.061 P=0.018 * P=0.028 * |
|POLY 1.5 | P=0.024 * P=0.497 P=0.244 P=0.071 |P=0.025 * P=0.058 P=0.017 * P=0.029 * |
|POLY 6 | P=0.038 * P=0.496 P=0.258 P=0.100 |P=0.022 * P=0.069 P=0.020 * P=0.025 * |
|LOGISTIC REGRESSION| P=0.016 * P=0.506 P=0.198 P=0.238 |P=0.020 * P=0.085 P=0.033 * P=0.029 * |
|COCH-ARM / FISHERS | P=0.019 * P=0.500 P=0.247 P=0.059 |P=0.027 * P=0.056 P=0.015 * P=0.030 * |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/50 (36%) 27/50 (54%) 22/50 (44%) 25/50 (50%) |3/50 (6%) 7/50 (14%) 6/50 (12%) 7/50 (14%) |
|POLY-3 ADJUSTED (b)| 46.2% 65.0% 51.8% 53.9% |7.3% 16.0% 13.6% 16.3% |
|TERMINAL (d) | 6/12 (50%) 9/16 (56%) 9/21 (43%) 17/31 (55%) |3/28 (11%) 5/33 (15%) 4/34 (12%) 2/28 (7%) |
|FIRST INCIDENCE | 647 563 521 544 |738 (T) 430 399 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.056N P=0.167 P=0.477N P=0.118N |P=0.158 P=0.223 P=0.327 P=0.163 |
|POLY 3 | P=0.456 P=0.056 P=0.383 P=0.307 |P=0.183 P=0.182 P=0.276 P=0.173 |
|POLY 1.5 | P=0.303 P=0.050 P=0.325 P=0.199 |P=0.175 P=0.168 P=0.261 P=0.168 |
|POLY 6 | P=0.386N P=0.087 P=0.491 P=0.495 |P=0.191 P=0.205 P=0.296 P=0.180 |
|LOGISTIC REGRESSION| P=0.377 P=0.024 * P=0.288 P=0.334 |P=0.160 P=0.166 P=0.248 P=0.158 |
|COCH-ARM / FISHERS | P=0.171 P=0.054 P=0.270 P=0.113 |P=0.161 P=0.159 P=0.243 P=0.159 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone |
| Osteopetrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |6/50 (12%) 1/50 (2%) 4/50 (8%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.7% 0.0% 0.0% |14.5% 2.3% 9.3% 4.9% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) |3/28 (11%) 0/33 (0%) 4/34 (12%) 1/28 (4%) |
|FIRST INCIDENCE | --- 614 --- --- |698 698 738 (T) 634 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.474N P=0.489 (e) (e) |P=0.157N P=0.040N* P=0.273N P=0.154N |
|POLY 3 | P=0.497N P=0.495 (e) (e) |P=0.157N P=0.050N P=0.347N P=0.134N |
|POLY 1.5 | P=0.499N P=0.497 (e) (e) |P=0.152N P=0.054N P=0.357N P=0.133N |
|POLY 6 | P=0.490N P=0.496 (e) (e) |P=0.168N P=0.044N* P=0.333N P=0.139N |
|LOGISTIC REGRESSION| P=0.520N P=0.507 (e) (e) |P=0.153N P=0.049N* P=0.312N P=0.138N |
|COCH-ARM / FISHERS | P=0.500N P=0.500 (e) (e) |P=0.152N P=0.056N P=0.370N P=0.134N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 33/50 (66%) 36/50 (72%) 32/50 (64%) |11/50 (22%) 14/50 (28%) 17/50 (34%) 21/50 (42%) |
|POLY-3 ADJUSTED (b)| 67.6% 74.9% 77.7% 67.1% |25.3% 31.4% 38.2% 45.1% |
|TERMINAL (d) | 5/12 (42%) 11/16 (69%) 16/21 (76%) 19/31 (61%) |3/28 (11%) 6/33 (18%) 12/34 (35%) 9/28 (32%) |
|FIRST INCIDENCE | 396 435 360 518 |475 535 535 444 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.013N* P=0.477 P=0.505N P=0.019N* |P=0.023 * P=0.474 P=0.273 P=0.046 * |
|POLY 3 | P=0.528N P=0.291 P=0.188 P=0.569N |P=0.020 * P=0.346 P=0.140 P=0.037 * |
|POLY 1.5 | P=0.423 P=0.309 P=0.170 P=0.524 |P=0.018 * P=0.326 P=0.135 P=0.032 * |
|POLY 6 | P=0.401N P=0.280 P=0.206 P=0.475N |P=0.022 * P=0.383 P=0.146 P=0.042 * |
|LOGISTIC REGRESSION| P=0.385 P=0.304 P=0.151 P=0.504 |P=0.015 * P=0.324 P=0.140 P=0.025 * |
|COCH-ARM / FISHERS | P=0.297 P=0.339 P=0.146 P=0.418 |P=0.015 * P=0.322 P=0.133 P=0.026 * |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Myelofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 2.7% 5.5% 0.0% 2.3% |2.4% 2.3% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 684 698 --- 708 |705 698 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.265N P=0.516 P=0.500N P=0.645N |P=0.176N P=0.722N P=0.470N P=0.513N |
|POLY 3 | P=0.390N P=0.488 P=0.497N P=0.726N |P=0.174N P=0.752N P=0.492N P=0.502N |
|POLY 1.5 | P=0.401N P=0.493 P=0.498N P=0.743N |P=0.172N P=0.757N P=0.496N P=0.501N |
|POLY 6 | P=0.371N P=0.485 P=0.494N P=0.701N |P=0.177N P=0.742N P=0.486N P=0.506N |
|LOGISTIC REGRESSION| P=0.346N P=0.487 P=0.496N P=0.742N |P=0.169N P=0.759N P=0.494N P=0.502N |
|COCH-ARM / FISHERS | P=0.411N P=0.500 P=0.500N P=0.753N |P=0.170N P=0.753N P=0.500N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/50 (0%) 6/50 (12%) 2/50 (4%) |0/50 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 10.3% 0.0% 14.7% 4.5% |0.0% 2.3% 0.0% 4.7% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 564 --- 527 518 |--- 392 --- 444 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.428N P=0.080N P=0.388 P=0.235N |P=0.154 P=0.496 (e) P=0.237 |
|POLY 3 | P=0.447N P=0.069N P=0.397 P=0.278N |P=0.156 P=0.512 (e) P=0.243 |
|POLY 1.5 | P=0.496N P=0.065N P=0.385 P=0.305N |P=0.153 P=0.506 (e) P=0.242 |
|POLY 6 | P=0.377N P=0.074N P=0.419 P=0.244N |P=0.160 P=0.521 (e) P=0.242 |
|LOGISTIC REGRESSION| P=0.470 P=0.059N P=0.350 P=0.404N |P=0.054 P=0.735 (e) P=0.166 |
|COCH-ARM / FISHERS | P=0.553N P=0.059N P=0.370 P=0.339N |P=0.149 P=0.500 (e) P=0.247 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |10/50 (20%) 12/50 (24%) 14/48 (29%) 11/50 (22%) |
|POLY-3 ADJUSTED (b)| |23.7% 27.4% 33.5% 25.7% |
|TERMINAL (d) | |6/28 (21%) 10/33 (30%) 13/34 (38%) 6/28 (21%) |
|FIRST INCIDENCE | |523 535 600 586 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.381 P=0.554 P=0.409 P=0.487 |
|POLY 3 | |P=0.377 P=0.438 P=0.223 P=0.512 |
|POLY 1.5 | |P=0.377 P=0.415 P=0.214 P=0.508 |
|POLY 6 | |P=0.371 P=0.477 P=0.241 P=0.515 |
|LOGISTIC REGRESSION| |P=0.362 P=0.435 P=0.253 P=0.497 |
|COCH-ARM / FISHERS | |P=0.370 P=0.405 P=0.206 P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |4/50 (8%) 11/50 (22%) 4/48 (8%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| |9.4% 24.1% 9.3% 12.0% |
|TERMINAL (d) | |1/28 (4%) 6/33 (18%) 2/34 (6%) 3/28 (11%) |
|FIRST INCIDENCE | |544 337 417 572 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.383N P=0.080 P=0.590N P=0.502 |
|POLY 3 | |P=0.398N P=0.059 P=0.638N P=0.487 |
|POLY 1.5 | |P=0.394N P=0.051 P=0.638 P=0.494 |
|POLY 6 | |P=0.410N P=0.071 P=0.624N P=0.474 |
|LOGISTIC REGRESSION| |P=0.408N P=0.045 * P=0.587 P=0.500 |
|COCH-ARM / FISHERS | |P=0.395N P=0.045 * P=0.619 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Coagulating Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/2 (100%) 1/1 (100%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|POLY-3 ADJUSTED (b)| 100.0% 100.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 715 736 (T) --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Epididymis |
| Granuloma Sperm |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | |
|POLY-3 ADJUSTED (b)| 0.0% 5.4% 0.0% 0.0% | |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) | |
|FIRST INCIDENCE | --- 507 --- --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.334N P=0.229 (e) (e) | |
|POLY 3 | P=0.352N P=0.234 (e) (e) | |
|POLY 1.5 | P=0.363N P=0.235 (e) (e) | |
|POLY 6 | P=0.331N P=0.235 (e) (e) | |
|LOGISTIC REGRESSION| P=0.403N P=0.247 (e) (e) | |
|COCH-ARM / FISHERS | P=0.375N P=0.247 (e) (e) | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/1 (0%) 0/4 (0%) 0/1 (0%) 0/3 (0%) |2/3 (67%) 0/3 (0%) 0/2 (0%) 0/2 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |70.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 0/2 (0%) 0/1 (0%) 0/3 (0%) |2/2 (100%) 0/2 (0%) 0/0 (0%) 0/1 (0%) |
|FIRST INCIDENCE | --- --- --- --- |738 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.132N P=0.193N P=1.000N P=0.362N |
|POLY 3 | (e) (e) (e) (e) |P=0.059N P=0.146N P=0.485N P=0.350N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.050N P=0.152N P=0.404N P=0.318N |
|POLY 6 | (e) (e) (e) (e) |P=0.066N P=0.134N P=0.572N P=0.393N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.132N (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.066N P=0.200N P=0.300N P=0.300N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Lens |
| Cataract |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/1 (100%) 3/4 (75%) 0/1 (0%) 3/3 (100%) |0/3 (0%) 2/3 (67%) 2/2 (100%) 2/2 (100%) |
|POLY-3 ADJUSTED (b)| 100.0% 77.1% 0.0% 100.0% |0.0% 70.3% 100.0% 100.0% |
|TERMINAL (d) | 0/0 (0%) 2/2 (100%) 0/1 (0%) 3/3 (100%) |0/2 (0%) 2/2 (100%) 0/0 (0%) 1/1 (100%) |
|FIRST INCIDENCE | 396 592 --- 736 (T) |--- 738 (T) 417 586 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.186N P=0.759N P=0.510N (e) |P=0.041 * P=0.193 P=0.262 P=0.161 |
|POLY 3 | P=0.584 P=0.783N P=1.000N (e) |P<0.001 ** P=0.146 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P=0.569 P=0.766N P=1.000N (e) |P<0.001 ** P=0.152 P<0.001 ** P<0.001 ** |
|POLY 6 | P=0.615 P=0.817N P=1.000N (e) |P<0.001 ** P=0.134 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.351 (e) (e) (e) |P=0.028 * P=0.193 (e) P=0.174 |
|COCH-ARM / FISHERS | P=0.550 P=0.800N P=0.500N (e) |P=0.015 * P=0.200 P=0.100 P=0.100 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Lens |
| Synechia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/1 (0%) 0/4 (0%) 0/1 (0%) 0/3 (0%) |0/3 (0%) 2/3 (67%) 0/2 (0%) 0/2 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 66.7% 0.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 0/2 (0%) 0/1 (0%) 0/3 (0%) |0/2 (0%) 1/2 (50%) 0/0 (0%) 0/1 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- 698 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.503N P=0.257 (e) (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.698N P=0.172 (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.606N P=0.165 (e) (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.626 P=0.185 (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.610N P=0.186 (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.471N P=0.200 (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Retina |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/1 (100%) 4/4 (100%) 0/1 (0%) 3/3 (100%) |0/3 (0%) 3/3 (100%) 2/2 (100%) 2/2 (100%) |
|POLY-3 ADJUSTED (b)| 100.0% 100.0% 0.0% 100.0% |0.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 0/0 (0%) 2/2 (100%) 0/1 (0%) 3/3 (100%) |0/2 (0%) 2/2 (100%) 0/0 (0%) 1/1 (100%) |
|FIRST INCIDENCE | 396 592 --- 736 (T) |--- 698 417 586 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.119N (e) P=0.510N (e) |P=0.083 P=0.104 P=0.262 P=0.161 |
|POLY 3 | P=1.000N (e) P=1.000N (e) |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P=1.000N (e) P=1.000N (e) |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P=1.000 (e) P=1.000N (e) |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.032 * P=0.051 (e) P=0.174 |
|COCH-ARM / FISHERS | P=0.567N (e) P=0.500N (e) |P=0.016 * P=0.050 P=0.100 P=0.100 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 41/50 (82%) 41/50 (82%) 41/50 (82%) 44/50 (88%) |27/50 (54%) 31/50 (62%) 36/50 (72%) 35/50 (70%) |
|POLY-3 ADJUSTED (b)| 87.8% 87.0% 89.0% 89.3% |58.9% 66.8% 79.6% 77.2% |
|TERMINAL (d) | 12/12 (100%) 15/16 (94%) 21/21 (100%) 27/31 (87%) |15/28 (54%) 22/33 (67%) 29/34 (85%) 22/28 (79%) |
|FIRST INCIDENCE | 396 410 360 213 |461 284 535 459 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.391N P=0.094N P<0.001N** |P=0.055 P=0.554 P=0.290 P=0.114 |
|POLY 3 | P=0.411 P=0.588N P=0.565 P=0.541 |P=0.011 * P=0.280 P=0.021 * P=0.041 * |
|POLY 1.5 | P=0.336 P=0.579N P=0.600 P=0.433 |P=0.017 * P=0.266 P=0.028 * P=0.053 |
|POLY 6 | P=0.531 P=0.633N P=0.480 P=0.620N |P=0.006 ** P=0.313 P=0.017 * P=0.030 * |
|LOGISTIC REGRESSION| P=0.334 P=0.580 P=0.580N P=0.356 |P=0.030 * P=0.278 P=0.060 P=0.071 |
|COCH-ARM / FISHERS | P=0.248 P=0.602N P=0.602N P=0.288 |P=0.032 * P=0.272 P=0.048 * P=0.074 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Heart: Atrium |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 7/50 (14%) 4/50 (8%) 2/50 (4%) |0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 18.5% 18.4% 10.4% 4.6% |0.0% 2.3% 0.0% 0.0% |
|TERMINAL (d) | 3/12 (25%) 1/16 (6%) 2/21 (10%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 684 507 640 708 |--- 620 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.003N** P=0.532N P=0.109N P=0.004N** |P=0.509N P=0.514 (e) (e) |
|POLY 3 | P=0.018N* P=0.611N P=0.242N P=0.048N* |P=0.502N P=0.510 (e) (e) |
|POLY 1.5 | P=0.025N* P=0.613N P=0.251N P=0.061N |P=0.501N P=0.504 (e) (e) |
|POLY 6 | P=0.011N* P=0.596N P=0.225N P=0.033N* |P=0.507N P=0.520 (e) (e) |
|LOGISTIC REGRESSION| P=0.019N* P=0.588 P=0.210N P=0.017N* |P=0.507N P=0.508 (e) (e) |
|COCH-ARM / FISHERS | P=0.037N* P=0.613N P=0.262N P=0.080N |P=0.500N P=0.500 (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Large, Colon |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 1/50 (2%) 3/49 (6%) |0/50 (0%) 2/50 (4%) 1/50 (2%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| 2.7% 7.9% 2.6% 7.0% |0.0% 4.7% 2.3% 12.3% |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 1/21 (5%) 1/30 (3%) |0/28 (0%) 2/33 (6%) 0/34 (0%) 5/28 (18%) |
|FIRST INCIDENCE | 736 (T) 410 736 (T) 708 |--- 738 (T) 417 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.532 P=0.330 P=0.633N P=0.596 |P=0.016 * P=0.275 P=0.500 P=0.032 * |
|POLY 3 | P=0.365 P=0.310 P=0.757N P=0.355 |P=0.018 * P=0.246 P=0.513 P=0.029 * |
|POLY 1.5 | P=0.337 P=0.308 P=0.759N P=0.328 |P=0.018 * P=0.240 P=0.507 P=0.030 * |
|POLY 6 | P=0.414 P=0.317 P=0.753N P=0.398 |P=0.019 * P=0.256 P=0.520 P=0.027 * |
|LOGISTIC REGRESSION| P=0.279 P=0.325 P=0.633N P=0.439 |P=0.018 * P=0.275 P=0.541 P=0.032 * |
|COCH-ARM / FISHERS | P=0.307 P=0.309 P=0.753N P=0.301 |P=0.018 * P=0.247 P=0.500 P=0.028 * |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 3/50 (6%) 3/49 (6%) |2/50 (4%) 5/50 (10%) 8/50 (16%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| 2.7% 13.1% 7.7% 7.0% |4.9% 11.7% 18.3% 12.1% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 3/30 (10%) |2/28 (7%) 5/33 (15%) 7/34 (21%) 2/28 (7%) |
|FIRST INCIDENCE | 643 507 583 736 (T) |738 (T) 738 (T) 451 605 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.511N P=0.098 P=0.373 P=0.577 |P=0.116 P=0.284 P=0.081 P=0.216 |
|POLY 3 | P=0.424 P=0.102 P=0.313 P=0.349 |P=0.124 P=0.231 P=0.055 P=0.218 |
|POLY 1.5 | P=0.381 P=0.101 P=0.310 P=0.325 |P=0.125 P=0.222 P=0.051 P=0.218 |
|POLY 6 | P=0.491 P=0.105 P=0.322 P=0.387 |P=0.121 P=0.250 P=0.061 P=0.216 |
|LOGISTIC REGRESSION| P=0.321 P=0.111 P=0.308 P=0.391 |P=0.116 P=0.284 P=0.054 P=0.210 |
|COCH-ARM / FISHERS | P=0.336 P=0.102 P=0.309 P=0.301 |P=0.123 P=0.218 P=0.046 * P=0.218 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 1/48 (2%) |0/50 (0%) 0/49 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 0.0% 2.4% |0.0% 0.0% 0.0% 2.5% |
|TERMINAL (d) | 2/12 (17%) 0/16 (0%) 0/21 (0%) 1/30 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 1/28 (4%) |
|FIRST INCIDENCE | 736 (T) --- --- 736 (T) |--- --- --- 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.126N P=0.175N P=0.124N P=0.200N |P=0.178 (e) (e) P=0.500 |
|POLY 3 | P=0.309N P=0.244N P=0.232N P=0.462N |P=0.194 (e) (e) P=0.498 |
|POLY 1.5 | P=0.310N P=0.241N P=0.234N P=0.487N |P=0.190 (e) (e) P=0.499 |
|POLY 6 | P=0.305N P=0.245N P=0.226N P=0.426N |P=0.200 (e) (e) P=0.495 |
|LOGISTIC REGRESSION| P=0.126N (e) (e) P=0.200N |(e) (e) (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.309N P=0.247N P=0.247N P=0.515N |P=0.186 (e) (e) P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 1/50 (2%) 1/50 (2%) |1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 2.7% 10.8% 2.6% 2.3% |2.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 1/21 (5%) 1/31 (3%) |1/28 (4%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 681 507 736 (T) 736 (T) |738 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.176N P=0.198 P=0.704N P=0.616N |P=0.176N P=0.467N P=0.461N P=0.500N |
|POLY 3 | P=0.312N P=0.172 P=0.758N P=0.727N |P=0.192N P=0.492N P=0.491N P=0.502N |
|POLY 1.5 | P=0.337N P=0.175 P=0.759N P=0.743N |P=0.188N P=0.497N P=0.495N P=0.501N |
|POLY 6 | P=0.273N P=0.172 P=0.755N P=0.702N |P=0.199N P=0.483N P=0.485N P=0.505N |
|LOGISTIC REGRESSION| P=0.330N P=0.176 P=0.751N P=0.719N |P=0.176N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.365N P=0.181 P=0.753N P=0.753N |P=0.185N P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 49/50 (98%) 50/50 (100%) 49/50 (98%) |44/50 (88%) 46/50 (92%) 44/50 (88%) 48/50 (96%) |
|POLY-3 ADJUSTED (b)| 100.0% 99.3% 100.0% 100.0% |95.7% 96.2% 92.8% 97.9% |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%)|28/28 (100%) 33/33 (100%) 34/34 (100%) 28/28 (100%) |
|FIRST INCIDENCE | 396 410 360 518 |507 284 451 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.359N (e) P<0.001N** |P=0.293 P=0.267N P=0.126N P=0.279 |
|POLY 3 | P=0.856 P=0.981N (e) P=1.000N |P=0.442 P=0.705 P=0.420N P=0.478 |
|POLY 1.5 | P=0.757 P=0.774N (e) P=1.000N |P=0.284 P=0.504 P=0.526N P=0.256 |
|POLY 6 | P=1.000 P=1.000N (e) P=1.000N |P=0.544N P=0.678N P=0.292N P=0.883 |
|LOGISTIC REGRESSION| P=0.538N P=0.506N (e) (e) |P=0.182 P=0.259 P=0.522N P=0.118 |
|COCH-ARM / FISHERS | P=0.375N P=0.500N (e) P=0.500N |P=0.160 P=0.370 P=0.620N P=0.134 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 48/50 (96%) 49/50 (98%) 50/50 (100%)|48/50 (96%) 48/50 (96%) 50/50 (100%) 50/50 (100%) |
|POLY-3 ADJUSTED (b)| 98.7% 98.4% 99.8% 100.0% |98.4% 99.6% 100.0% 100.0% |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%)|28/28 (100%) 33/33 (100%) 34/34 (100%) 28/28 (100%) |
|FIRST INCIDENCE | 396 410 443 213 |391 337 399 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.353N P=0.114N P<0.001N** |P=0.350 P=0.179N P=0.246N P=0.408 |
|POLY 3 | P=0.207 P=0.832N P=0.748 P=0.690 |P=0.114 P=0.759 P=0.636 P=0.636 |
|POLY 1.5 | P=0.204 P=0.685N P=0.725 P=0.588 |P=0.063 P=0.649 P=0.384 P=0.384 |
|POLY 6 | P=0.292 P=0.953 P=0.899 P=0.892 |P=0.508 P=0.998 P=0.997 P=0.997 |
|LOGISTIC REGRESSION| P=0.261 P=0.522N P=0.744N P=0.520 |P=0.057 P=0.493 P=0.243 P=0.249 |
|COCH-ARM / FISHERS | P=0.249 P=0.500N P=0.753N P=0.500 |P=0.057 P=0.691N P=0.247 P=0.247 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 2.6% 2.3% |0.0% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 647 --- 736 (T) 736 (T) |--- --- --- 613 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.237N P=0.241N P=0.422N P=0.312N |P=0.179 (e) (e) P=0.495 |
|POLY 3 | P=0.384N P=0.246N P=0.497N P=0.451N |P=0.192 (e) (e) P=0.500 |
|POLY 1.5 | P=0.397N P=0.243N P=0.498N P=0.473N |P=0.189 (e) (e) P=0.501 |
|POLY 6 | P=0.362N P=0.250N P=0.493N P=0.418N |P=0.197 (e) (e) P=0.499 |
|LOGISTIC REGRESSION| P=0.334N P=0.244N P=0.487N P=0.449N |P=0.177 (e) (e) P=0.495 |
|COCH-ARM / FISHERS | P=0.411N P=0.247N P=0.500N P=0.500N |P=0.185 (e) (e) P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 14/50 (28%) 20/50 (40%) 16/50 (32%) |41/50 (82%) 42/50 (84%) 44/50 (88%) 35/50 (70%) |
|POLY-3 ADJUSTED (b)| 42.0% 37.9% 49.6% 36.2% |86.2% 92.9% 93.8% 79.0% |
|TERMINAL (d) | 10/12 (83%) 12/16 (75%) 16/21 (76%) 14/31 (45%) |27/28 (96%) 33/33 (100%) 34/34 (100%) 25/28 (89%) |
|FIRST INCIDENCE | 396 563 360 544 |391 522 399 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.091N P=0.197N P=0.002N** |P=0.159N P=0.220N P=0.302N P=0.186N |
|POLY 3 | P=0.424N P=0.442N P=0.314 P=0.368N |P=0.195N P=0.213 P=0.154 P=0.237N |
|POLY 1.5 | P=0.517N P=0.396N P=0.325 P=0.436N |P=0.138N P=0.286 P=0.203 P=0.175N |
|POLY 6 | P=0.272N P=0.488N P=0.310 P=0.261N |P=0.319N P=0.191 P=0.119 P=0.345N |
|LOGISTIC REGRESSION| P=0.309N P=0.381N P=0.358 P=0.339N |P=0.076N P=0.501 P=0.332 P=0.107N |
|COCH-ARM / FISHERS | P=0.447 P=0.333N P=0.339 P=0.500N |P=0.113N P=0.500 P=0.288 P=0.121N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/50 (4%) 7/50 (14%) 5/50 (10%) |11/50 (22%) 10/50 (20%) 8/50 (16%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 16.0% 5.5% 18.3% 11.5% |26.8% 23.4% 18.6% 7.4% |
|TERMINAL (d) | 6/12 (50%) 2/16 (13%) 7/21 (33%) 5/31 (16%) |11/28 (39%) 10/33 (30%) 8/34 (24%) 3/28 (11%) |
|FIRST INCIDENCE | 736 (T) 736 (T) 736 (T) 736 (T) |738 (T) 738 (T) 738 (T) 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.070N P=0.043N* P=0.287N P=0.031N* |P=0.008N** P=0.322N P=0.146N P=0.016N* |
|POLY 3 | P=0.509N P=0.139N P=0.516 P=0.393N |P=0.014N* P=0.458N P=0.262N P=0.018N* |
|POLY 1.5 | P=0.527 P=0.137N P=0.509 P=0.443N |P=0.014N* P=0.485N P=0.282N P=0.019N* |
|POLY 6 | P=0.420N P=0.138N P=0.535 P=0.320N |P=0.015N* P=0.411N P=0.235N P=0.018N* |
|LOGISTIC REGRESSION| P=0.070N P=0.043N* P=0.287N P=0.031N* |P=0.008N** P=0.322N P=0.146N P=0.016N* |
|COCH-ARM / FISHERS | P=0.458 P=0.134N P=0.500 P=0.500N |P=0.016N* P=0.500N P=0.306N P=0.020N* |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 1/50 (2%) 9/50 (18%) |2/50 (4%) 1/50 (2%) 1/50 (2%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 5.3% 5.5% 2.6% 20.4% |4.8% 2.3% 2.3% 7.3% |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 1/21 (5%) 7/31 (23%) |1/28 (4%) 1/33 (3%) 1/34 (3%) 2/28 (7%) |
|FIRST INCIDENCE | 619 649 736 (T) 605 |620 738 (T) 738 (T) 634 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.099 P=0.672N P=0.393N P=0.243 |P=0.359 P=0.454N P=0.452N P=0.491 |
|POLY 3 | P=0.011 * P=0.682 P=0.497N P=0.045 * |P=0.367 P=0.489N P=0.488N P=0.495 |
|POLY 1.5 | P=0.009 ** P=0.687 P=0.498N P=0.035 * |P=0.368 P=0.497N P=0.493N P=0.499 |
|POLY 6 | P=0.014 * P=0.679 P=0.493N P=0.065 |P=0.366 P=0.477N P=0.480N P=0.488 |
|LOGISTIC REGRESSION| P=0.025 * P=0.684 P=0.489N P=0.057 |P=0.363 P=0.495N P=0.493N P=0.498 |
|COCH-ARM / FISHERS | P=0.009 ** P=0.691N P=0.500N P=0.026 * |P=0.365 P=0.500N P=0.500N P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 7/50 (14%) 6/50 (12%) 8/50 (16%) |9/50 (18%) 4/50 (8%) 7/50 (14%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 0.0% 18.6% 15.1% 17.7% |21.1% 9.0% 15.8% 7.3% |
|TERMINAL (d) | 0/12 (0%) 3/16 (19%) 3/21 (14%) 5/31 (16%) |6/28 (21%) 2/33 (6%) 5/34 (15%) 2/28 (7%) |
|FIRST INCIDENCE | --- 505 521 213 |475 337 417 704 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.121 P=0.015 * P=0.039 * P=0.043 * |P=0.080N P=0.089N P=0.285N P=0.068N |
|POLY 3 | P=0.028 * P=0.007 ** P=0.018 * P=0.008 ** |P=0.096N P=0.097N P=0.360N P=0.067N |
|POLY 1.5 | P=0.019 * P=0.007 ** P=0.017 * P=0.006 ** |P=0.089N P=0.106N P=0.374N P=0.063N |
|POLY 6 | P=0.050 P=0.007 ** P=0.020 * P=0.014 * |P=0.108N P=0.086N P=0.341N P=0.073N |
|LOGISTIC REGRESSION| P=0.009 ** P=0.008 ** P=0.017 * P=0.003 ** |P=0.085N P=0.112N P=0.402N P=0.062N |
|COCH-ARM / FISHERS | P=0.012 * P=0.006 ** P=0.013 * P=0.003 ** |P=0.083N P=0.117N P=0.393N P=0.061N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 16/50 (32%) 22/50 (44%) 22/50 (44%) |31/50 (62%) 36/50 (72%) 33/50 (66%) 27/50 (54%) |
|POLY-3 ADJUSTED (b)| 51.3% 40.0% 52.0% 48.9% |69.4% 78.5% 73.5% 62.9% |
|TERMINAL (d) | 9/12 (75%) 9/16 (56%) 13/21 (62%) 19/31 (61%) |22/28 (79%) 29/33 (88%) 28/34 (82%) 19/28 (68%) |
|FIRST INCIDENCE | 396 428 360 544 |507 284 399 592 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.010N* P=0.080N P=0.156N P=0.003N** |P=0.180N P=0.557 P=0.323N P=0.306N |
|POLY 3 | P=0.485 P=0.197N P=0.564 P=0.494N |P=0.230N P=0.217 P=0.421 P=0.329N |
|POLY 1.5 | P=0.423 P=0.178N P=0.567 P=0.545N |P=0.197N P=0.197 P=0.420 P=0.298N |
|POLY 6 | P=0.468N P=0.215N P=0.579 P=0.401N |P=0.290N P=0.263 P=0.428 P=0.382N |
|LOGISTIC REGRESSION| P=0.457 P=0.152N P=0.576N P=0.507N |P=0.164N P=0.211 P=0.515 P=0.270N |
|COCH-ARM / FISHERS | P=0.374 P=0.151N P=0.580N P=0.580N |P=0.179N P=0.198 P=0.418 P=0.272N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |7/50 (14%) 7/50 (14%) 5/50 (10%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 2.7% 0.0% 2.6% 2.3% |17.0% 16.4% 11.6% 4.9% |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 1/31 (3%) |7/28 (25%) 7/33 (21%) 5/34 (15%) 2/28 (7%) |
|FIRST INCIDENCE | 736 (T) --- 645 736 (T) |738 (T) 738 (T) 738 (T) 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.532N P=0.443N P=0.711N P=0.537N |P=0.037N* P=0.482N P=0.244N P=0.075N |
|POLY 3 | P=0.555 P=0.507N P=0.755N P=0.726N |P=0.048N* P=0.583N P=0.346N P=0.078N |
|POLY 1.5 | P=0.529 P=0.504N P=0.758N P=0.742N |P=0.048N* P=0.603N P=0.362N P=0.078N |
|POLY 6 | P=0.593 P=0.509N P=0.749N P=0.699N |P=0.051N P=0.549N P=0.324N P=0.080N |
|LOGISTIC REGRESSION| P=0.564 (e) P=0.757N P=0.537N |P=0.037N* P=0.482N P=0.244N P=0.075N |
|COCH-ARM / FISHERS | P=0.500 P=0.500N P=0.753N P=0.753N |P=0.049N* P=0.613N P=0.380N P=0.080N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation Bile |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 4.6% 2.3% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 1/34 (3%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- 620 738 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.508N P=0.271 P=0.539 (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.504N P=0.249 P=0.509 (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.501N P=0.242 P=0.505 (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.512N P=0.261 P=0.515 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.500N P=0.237 P=0.539 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.500N P=0.247 P=0.500 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |4.8% 2.3% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- |391 698 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.060N P=0.462N P=0.220N P=0.243N |
|POLY 3 | (e) (e) (e) (e) |P=0.061N P=0.493N P=0.232N P=0.244N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.060N P=0.499N P=0.235N P=0.241N |
|POLY 6 | (e) (e) (e) (e) |P=0.063N P=0.479N P=0.227N P=0.249N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.062N P=0.476N P=0.246N P=0.248N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.059N P=0.500N P=0.247N P=0.247N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 47/50 (94%) 46/50 (92%) 48/50 (96%) |24/50 (48%) 18/50 (36%) 22/50 (44%) 19/50 (38%) |
|POLY-3 ADJUSTED (b)| 99.1% 95.4% 94.6% 99.1% |56.1% 39.5% 46.8% 44.3% |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 20/21 (95%) 31/31 (100%)|16/28 (57%) 10/33 (30%) 13/34 (38%) 14/28 (50%) |
|FIRST INCIDENCE | 396 410 443 518 |585 430 535 586 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.313N P=0.062N P<0.001N** |P=0.280N P=0.073N P=0.218N P=0.238N |
|POLY 3 | P=0.546N P=0.286N P=0.217N P=0.949 |P=0.240N P=0.083N P=0.249N P=0.183N |
|POLY 1.5 | P=0.498N P=0.291N P=0.205N P=0.820N |P=0.242N P=0.113N P=0.320N P=0.190N |
|POLY 6 | P=0.565N P=0.292N P=0.227N P=1.000 |P=0.250N P=0.054N P=0.175N P=0.189N |
|LOGISTIC REGRESSION| P=0.229N P=0.311N P=0.165N P=0.407N |P=0.258N P=0.131N P=0.377N P=0.214N |
|COCH-ARM / FISHERS | P=0.332N P=0.309N P=0.181N P=0.500N |P=0.261N P=0.156N P=0.421N P=0.210N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 22/50 (44%) 28/50 (56%) 39/50 (78%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 40.1% 55.6% 65.2% 81.7% |0.0% 0.0% 0.0% 2.5% |
|TERMINAL (d) | 4/12 (33%) 11/16 (69%) 14/21 (67%) 24/31 (77%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 1/28 (4%) |
|FIRST INCIDENCE | 576 507 527 561 |--- --- --- 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.176 P=0.289 P=0.182 P=0.218 |P=0.178 (e) (e) P=0.500 |
|POLY 3 | P<0.001 ** P=0.111 P=0.013 * P<0.001 ** |P=0.193 (e) (e) P=0.498 |
|POLY 1.5 | P<0.001 ** P=0.127 P=0.012 * P<0.001 ** |P=0.189 (e) (e) P=0.499 |
|POLY 6 | P<0.001 ** P=0.097 P=0.018 * P<0.001 ** |P=0.199 (e) (e) P=0.495 |
|LOGISTIC REGRESSION| P<0.001 ** P=0.102 P=0.013 * P<0.001 ** |(e) (e) (e) P=0.500 |
|COCH-ARM / FISHERS | P<0.001 ** P=0.151 P=0.013 * P<0.001 ** |P=0.185 (e) (e) P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 2/50 (4%) 1/50 (2%) |0/50 (0%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 7.8% 0.0% 5.2% 2.3% |0.0% 2.3% 4.7% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 2/34 (6%) 0/28 (0%) |
|FIRST INCIDENCE | 535 --- 521 736 (T) |--- 337 738 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.176N P=0.139N P=0.451N P=0.188N |P=0.502 P=0.496 P=0.282 (e) |
|POLY 3 | P=0.248N P=0.130N P=0.498N P=0.263N |P=0.496 P=0.512 P=0.247 (e) |
|POLY 1.5 | P=0.267N P=0.125N P=0.498N P=0.282N |P=0.499 P=0.506 P=0.242 (e) |
|POLY 6 | P=0.221N P=0.135N P=0.495N P=0.236N |P=0.488 P=0.521 P=0.254 (e) |
|LOGISTIC REGRESSION| P=0.315N P=0.113N P=0.511N P=0.339N |P=0.483 P=0.905 P=0.282 (e) |
|COCH-ARM / FISHERS | P=0.289N P=0.121N P=0.500N P=0.309N |P=0.500 P=0.500 P=0.247 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 3/50 (6%) 5/50 (10%) 7/50 (14%) |7/50 (14%) 2/50 (4%) 1/50 (2%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 24.6% 8.0% 13.0% 15.7% |16.8% 4.5% 2.3% 7.3% |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 4/21 (19%) 6/31 (19%) |3/28 (11%) 0/33 (0%) 1/34 (3%) 1/28 (4%) |
|FIRST INCIDENCE | 396 450 676 213 |645 337 738 (T) 613 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.053N P=0.050N P=0.071N P=0.051N |P=0.067N P=0.065N P=0.022N* P=0.188N |
|POLY 3 | P=0.224N P=0.044N* P=0.149N P=0.224N |P=0.063N P=0.064N P=0.026N* P=0.158N |
|POLY 1.5 | P=0.250N P=0.040N* P=0.141N P=0.254N |P=0.061N P=0.071N P=0.028N* P=0.157N |
|POLY 6 | P=0.189N P=0.050N P=0.160N P=0.187N |P=0.066N P=0.056N P=0.024N* P=0.163N |
|LOGISTIC REGRESSION| P=0.315N P=0.031N* P=0.130N P=0.385N |P=0.063N P=0.080N P=0.026N* P=0.161N |
|COCH-ARM / FISHERS | P=0.283N P=0.036N* P=0.131N P=0.298N |P=0.062N P=0.080N P=0.030N* P=0.159N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 1/50 (2%) |0/50 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 5.3% 2.8% 2.6% 2.3% |0.0% 0.0% 2.3% 2.5% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 1/28 (4%) |
|FIRST INCIDENCE | 617 726 593 621 |--- --- 733 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.235N P=0.488N P=0.466N P=0.387N |P=0.164 (e) P=0.545 P=0.500 |
|POLY 3 | P=0.308N P=0.516N P=0.493N P=0.448N |P=0.171 (e) P=0.509 P=0.498 |
|POLY 1.5 | P=0.325N P=0.509N P=0.496N P=0.472N |P=0.172 (e) P=0.505 P=0.499 |
|POLY 6 | P=0.283N P=0.522N P=0.486N P=0.413N |P=0.170 (e) P=0.515 P=0.495 |
|LOGISTIC REGRESSION| P=0.351N P=0.512N P=0.503N P=0.526N |P=0.156 (e) P=0.524 P=0.500 |
|COCH-ARM / FISHERS | P=0.343N P=0.500N P=0.500N P=0.500N |P=0.170 (e) P=0.500 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 1/50 (2%) 2/50 (4%) |2/50 (4%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 5.3% 10.7% 2.6% 4.6% |4.7% 0.0% 4.6% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 729 410 640 708 |391 --- 399 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.181N P=0.390 P=0.400N P=0.381N |P=0.241N P=0.244N P=0.668N P=0.230N |
|POLY 3 | P=0.325N P=0.335 P=0.490N P=0.637N |P=0.265N P=0.235N P=0.683N P=0.246N |
|POLY 1.5 | P=0.351N P=0.336 P=0.495N P=0.664N |P=0.256N P=0.239N P=0.688N P=0.242N |
|POLY 6 | P=0.283N P=0.340 P=0.480N P=0.595N |P=0.282N P=0.229N P=0.675N P=0.253N |
|LOGISTIC REGRESSION| P=0.367N P=0.333 P=0.485N P=0.515N |P=0.283N P=0.125N P=0.687 P=0.250N |
|COCH-ARM / FISHERS | P=0.380N P=0.339 P=0.500N P=0.691N |P=0.249N P=0.247N P=0.691N P=0.247N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 5/50 (10%) 4/50 (8%) |12/50 (24%) 12/50 (24%) 17/50 (34%) 15/50 (30%) |
|POLY-3 ADJUSTED (b)| 7.7% 0.0% 13.0% 9.2% |27.9% 27.4% 39.6% 36.1% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 4/21 (19%) 4/31 (13%) |7/28 (25%) 10/33 (30%) 17/34 (50%) 13/28 (46%) |
|FIRST INCIDENCE | 396 --- 676 736 (T) |523 522 738 (T) 605 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.510 P=0.126N P=0.533 P=0.478N |P=0.168 P=0.447N P=0.362 P=0.315 |
|POLY 3 | P=0.238 P=0.131N P=0.348 P=0.563 |P=0.137 P=0.575N P=0.176 P=0.279 |
|POLY 1.5 | P=0.206 P=0.126N P=0.351 P=0.533 |P=0.158 P=0.590N P=0.181 P=0.303 |
|POLY 6 | P=0.292 P=0.135N P=0.351 P=0.610 |P=0.106 P=0.547N P=0.170 P=0.241 |
|LOGISTIC REGRESSION| P=0.221 P=0.106N P=0.358 P=0.476 |P=0.160 P=0.577N P=0.235 P=0.311 |
|COCH-ARM / FISHERS | P=0.176 P=0.121N P=0.357 P=0.500 |P=0.180 P=0.592N P=0.189 P=0.326 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 3/50 (6%) 2/50 (4%) |5/50 (10%) 2/50 (4%) 5/50 (10%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 2.7% 13.5% 7.8% 4.6% |12.1% 4.7% 11.6% 7.2% |
|TERMINAL (d) | 1/12 (8%) 3/16 (19%) 2/21 (10%) 2/31 (7%) |4/28 (14%) 1/33 (3%) 4/34 (12%) 1/28 (4%) |
|FIRST INCIDENCE | 736 (T) 435 593 736 (T) |645 731 690 588 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.249N P=0.153 P=0.459 P=0.672N |P=0.404N P=0.164N P=0.525N P=0.360N |
|POLY 3 | P=0.519N P=0.096 P=0.316 P=0.553 |P=0.406N P=0.202N P=0.605N P=0.352N |
|POLY 1.5 | P=0.557 P=0.099 P=0.311 P=0.528 |P=0.402N P=0.211N P=0.617N P=0.353N |
|POLY 6 | P=0.449N P=0.095 P=0.327 P=0.589 |P=0.418N P=0.187N P=0.587N P=0.354N |
|LOGISTIC REGRESSION| P=0.536N P=0.096 P=0.318 P=0.672N |P=0.408N P=0.182N P=0.582N P=0.357N |
|COCH-ARM / FISHERS | P=0.500 P=0.102 P=0.309 P=0.500 |P=0.405N P=0.218N P=0.630N P=0.357N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 39/50 (78%) 37/50 (74%) 39/50 (78%) 40/50 (80%) |41/50 (82%) 42/50 (84%) 45/50 (90%) 46/50 (92%) |
|POLY-3 ADJUSTED (b)| 84.4% 81.9% 84.1% 86.4% |89.0% 90.5% 93.8% 96.0% |
|TERMINAL (d) | 10/12 (83%) 11/16 (69%) 18/21 (86%) 28/31 (90%) |28/28 (100%) 32/33 (97%) 33/34 (97%) 28/28 (100%) |
|FIRST INCIDENCE | 396 435 443 544 |461 430 399 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.344N P=0.143N P<0.001N** |P=0.150 P=0.221N P=0.365N P=0.218 |
|POLY 3 | P=0.391 P=0.481N P=0.608N P=0.508 |P=0.071 P=0.548 P=0.301 P=0.138 |
|POLY 1.5 | P=0.378 P=0.459N P=0.604N P=0.492 |P=0.065 P=0.489 P=0.248 P=0.128 |
|POLY 6 | P=0.392 P=0.474N P=0.616N P=0.524 |P=0.072 P=0.668N P=0.386 P=0.151 |
|LOGISTIC REGRESSION| P=0.449N P=0.452N P=0.577N P=0.427N |P=0.055 P=0.510 P=0.228 P=0.106 |
|COCH-ARM / FISHERS | P=0.381 P=0.408N P=0.595N P=0.500 |P=0.055 P=0.500 P=0.194 P=0.117 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) |1/50 (2%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 5.2% 2.3% |2.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 666 736 (T) |698 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.285 (e) P=0.300 P=0.689 |P=0.191N P=0.468N P=0.489N P=0.525N |
|POLY 3 | P=0.200 (e) P=0.242 P=0.530 |P=0.191N P=0.497N P=0.492N P=0.503N |
|POLY 1.5 | P=0.175 (e) P=0.240 P=0.516 |P=0.187N P=0.502N P=0.496N P=0.501N |
|POLY 6 | P=0.241 (e) P=0.248 P=0.551 |P=0.198N P=0.490N P=0.486N P=0.506N |
|LOGISTIC REGRESSION| P=0.202 (e) P=0.246 P=0.689 |P=0.184N P=0.502N P=0.496N P=0.501N |
|COCH-ARM / FISHERS | P=0.149 (e) P=0.247 P=0.500 |P=0.185N P=0.505N P=0.500N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 7.9% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 3/21 (14%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 736 (T) 736 (T) --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.491N P=0.557 P=0.232 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.519 P=0.493 P=0.121 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.468 P=0.496 P=0.120 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.592 P=0.491 P=0.124 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.557 P=0.232 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.411 P=0.500 P=0.121 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Pigmentation Hemosiderin |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 19/50 (38%) 23/50 (46%) 36/50 (72%) |30/50 (60%) 22/50 (44%) 21/50 (42%) 24/50 (48%) |
|POLY-3 ADJUSTED (b)| 58.0% 46.6% 55.8% 77.6% |66.1% 48.4% 43.9% 52.9% |
|TERMINAL (d) | 5/12 (42%) 7/16 (44%) 11/21 (52%) 25/31 (81%) |18/28 (64%) 14/33 (42%) 11/34 (32%) 13/28 (46%) |
|FIRST INCIDENCE | 396 507 593 605 |507 337 399 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.211N P=0.156N P=0.147N P=0.127N |P=0.172N P=0.038N* P=0.032N* P=0.223N |
|POLY 3 | P=0.011 * P=0.194N P=0.507N P=0.029 * |P=0.096N P=0.064N P=0.022N* P=0.137N |
|POLY 1.5 | P=0.009 ** P=0.177N P=0.470N P=0.021 * |P=0.102N P=0.071N P=0.031N* P=0.140N |
|POLY 6 | P=0.018 * P=0.215N P=0.545N P=0.052 |P=0.097N P=0.055N P=0.017N* P=0.146N |
|LOGISTIC REGRESSION| P=0.042 * P=0.169N P=0.394N P=0.057 |P=0.127N P=0.073N P=0.059N P=0.158N |
|COCH-ARM / FISHERS | P=0.011 * P=0.157N P=0.421N P=0.020 * |P=0.127N P=0.080N P=0.055N P=0.158N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/49 (4%) |0/50 (0%) 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 4.7% |0.0% 0.0% 7.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/30 (3%) |0/28 (0%) 0/33 (0%) 3/34 (9%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 666 684 |--- --- 738 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.118 (e) P=0.500 P=0.385 |P=0.297 (e) P=0.157 (e) |
|POLY 3 | P=0.074 (e) P=0.505 P=0.268 |P=0.287 (e) P=0.126 (e) |
|POLY 1.5 | P=0.066 (e) P=0.503 P=0.251 |P=0.294 (e) P=0.123 (e) |
|POLY 6 | P=0.088 (e) P=0.511 P=0.295 |P=0.274 (e) P=0.132 (e) |
|LOGISTIC REGRESSION| P=0.071 (e) P=0.501 P=0.280 |(e) (e) P=0.157 (e) |
|COCH-ARM / FISHERS | P=0.058 (e) P=0.500 P=0.242 |P=0.301 (e) P=0.121 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/47 (0%) 1/50 (2%) 1/49 (2%) |2/50 (4%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 2.3% |4.9% 4.7% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) |2/28 (7%) 1/33 (3%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 722 736 (T) |738 (T) 731 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.292 (e) P=0.560 P=0.689 |P=0.051N P=0.634N P=0.196N P=0.238N |
|POLY 3 | P=0.213 (e) P=0.508 P=0.531 |P=0.057N P=0.680N P=0.227N P=0.239N |
|POLY 1.5 | P=0.194 (e) P=0.506 P=0.517 |P=0.056N P=0.689N P=0.232N P=0.238N |
|POLY 6 | P=0.244 (e) P=0.513 P=0.553 |P=0.057N P=0.664N P=0.220N P=0.242N |
|LOGISTIC REGRESSION| P=0.253 (e) P=0.527 P=0.689 |P=0.052N P=0.635N (e) (e) |
|COCH-ARM / FISHERS | P=0.173 (e) P=0.505 P=0.500 |P=0.057N P=0.691N P=0.247N P=0.247N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 36/49 (73%) 34/47 (72%) 24/50 (48%) 28/49 (57%) |43/50 (86%) 44/50 (88%) 45/50 (90%) 42/50 (84%) |
|POLY-3 ADJUSTED (b)| 79.7% 79.9% 56.7% 62.6% |88.2% 93.4% 94.3% 86.4% |
|TERMINAL (d) | 8/12 (67%) 11/16 (69%) 11/21 (52%) 20/31 (65%) |24/28 (86%) 32/33 (97%) 32/34 (94%) 24/28 (86%) |
|FIRST INCIDENCE | 396 524 443 561 |461 392 451 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.346N P=0.005N** P<0.001N** |P=0.476N P=0.267N P=0.288N P=0.513N |
|POLY 3 | P=0.006N** P=0.602 P=0.011N* P=0.049N* |P=0.448N P=0.292 P=0.232 P=0.516N |
|POLY 1.5 | P=0.007N** P=0.592N P=0.008N** P=0.057N |P=0.429N P=0.342 P=0.276 P=0.495N |
|POLY 6 | P=0.006N** P=0.610 P=0.020N* P=0.043N* |P=0.512N P=0.272 P=0.213 P=0.574N |
|LOGISTIC REGRESSION| P=0.002N** P=0.537N P=0.007N** P=0.029N* |P=0.437N P=0.481 P=0.420 P=0.500N |
|COCH-ARM / FISHERS | P=0.011N* P=0.542N P=0.008N** P=0.068N |P=0.463N P=0.500 P=0.380 P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/15 (80%) 8/12 (67%) 8/15 (53%) 8/11 (73%) |3/8 (38%) 0/1 (0%) 3/5 (60%) 1/5 (20%) |
|POLY-3 ADJUSTED (b)| 83.4% 73.2% 60.3% 77.5% |42.2% 0.0% 71.7% 25.2% |
|TERMINAL (d) | 3/3 (100%) 0/1 (0%) 3/6 (50%) 5/5 (100%) |2/5 (40%) 0/1 (0%) 2/2 (100%) 1/2 (50%) |
|FIRST INCIDENCE | 593 534 563 610 |391 --- 684 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.016N* P=0.393N P=0.091N P=0.025N* |P=0.491 P=0.322N P=0.358 P=0.575N |
|POLY 3 | P=0.285N P=0.443N P=0.158N P=0.560N |P=0.571N P=0.611N P=0.367 P=0.532N |
|POLY 1.5 | P=0.275N P=0.408N P=0.140N P=0.542N |P=0.525N P=0.620N P=0.396 P=0.503N |
|POLY 6 | P=0.293N P=0.495N P=0.188N P=0.574N |P=0.515 P=0.599N P=0.308 P=0.591N |
|LOGISTIC REGRESSION| P=0.243N P=0.302N P=0.119N P=0.497N |P=0.479N P=0.714N P=0.419 P=0.495N |
|COCH-ARM / FISHERS | P=0.258N P=0.364N P=0.123N P=0.509N |P=0.488N P=0.667N P=0.413 P=0.490N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Fungus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 15/50 (30%) 10/50 (20%) 11/50 (22%) |6/50 (12%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 49.1% 36.9% 24.9% 24.2% |13.9% 4.6% 2.3% 0.0% |
|TERMINAL (d) | 6/12 (50%) 3/16 (19%) 5/21 (24%) 6/31 (19%) |1/28 (4%) 0/33 (0%) 1/34 (3%) 0/28 (0%) |
|FIRST INCIDENCE | 396 450 557 544 |461 337 738 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.157N P=0.004N** P<0.001N** |P=0.003N** P=0.123N P=0.051N P=0.021N* |
|POLY 3 | P=0.003N** P=0.174N P=0.016N* P=0.011N* |P=0.003N** P=0.127N P=0.056N P=0.018N* |
|POLY 1.5 | P=0.005N** P=0.164N P=0.015N* P=0.016N* |P=0.003N** P=0.132N P=0.056N P=0.017N* |
|POLY 6 | P=0.002N** P=0.175N P=0.017N* P=0.006N** |P=0.003N** P=0.119N P=0.054N P=0.020N* |
|LOGISTIC REGRESSION| P=0.009N** P=0.146N P=0.015N* P=0.033N* |P=0.003N** P=0.109N P=0.064N P=0.017N* |
|COCH-ARM / FISHERS | P=0.009N** P=0.149N P=0.015N* P=0.026N* |P=0.003N** P=0.134N P=0.056N P=0.013N* |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 19/50 (38%) 22/50 (44%) 18/50 (36%) |13/50 (26%) 13/50 (26%) 7/50 (14%) 6/50 (12%) |
|POLY-3 ADJUSTED (b)| 57.5% 46.7% 52.8% 39.5% |29.9% 28.9% 16.1% 14.4% |
|TERMINAL (d) | 7/12 (58%) 7/16 (44%) 13/21 (62%) 11/31 (36%) |7/28 (25%) 8/33 (24%) 6/34 (18%) 4/28 (14%) |
|FIRST INCIDENCE | 396 450 521 544 |461 337 544 571 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.142N P=0.075N P<0.001N** |P=0.020N* P=0.450N P=0.062N P=0.072N |
|POLY 3 | P=0.068N P=0.208N P=0.408N P=0.061N |P=0.021N* P=0.555N P=0.098N P=0.069N |
|POLY 1.5 | P=0.097N P=0.185N P=0.379N P=0.083N |P=0.020N* P=0.577N P=0.101N P=0.065N |
|POLY 6 | P=0.038N* P=0.230N P=0.443N P=0.037N* |P=0.025N* P=0.517N P=0.093N P=0.077N |
|LOGISTIC REGRESSION| P=0.087N P=0.166N P=0.328N P=0.097N |P=0.019N* P=0.588 P=0.103N P=0.063N |
|COCH-ARM / FISHERS | P=0.138N P=0.157N P=0.344N P=0.113N |P=0.019N* P=0.590N P=0.105N P=0.062N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Nasolacrimal Duct |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 6/50 (12%) 6/50 (12%) 5/50 (10%) |9/50 (18%) 6/50 (12%) 10/50 (20%) 6/50 (12%) |
|POLY-3 ADJUSTED (b)| 15.7% 16.3% 14.9% 11.5% |21.2% 13.9% 22.6% 14.2% |
|TERMINAL (d) | 1/12 (8%) 2/16 (13%) 2/21 (10%) 4/31 (13%) |5/28 (18%) 4/33 (12%) 6/34 (18%) 3/28 (11%) |
|FIRST INCIDENCE | 617 631 482 712 |523 701 600 459 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.093N P=0.544N P=0.469N P=0.118N |P=0.368N P=0.200N P=0.554N P=0.301N |
|POLY 3 | P=0.311N P=0.595 P=0.586N P=0.406N |P=0.361N P=0.276N P=0.538 P=0.286N |
|POLY 1.5 | P=0.361N P=0.606 P=0.600N P=0.449N |P=0.357N P=0.287N P=0.520 P=0.285N |
|POLY 6 | P=0.243N P=0.588 P=0.563N P=0.346N |P=0.377N P=0.255N P=0.567 P=0.295N |
|LOGISTIC REGRESSION| P=0.328N P=0.595 P=0.620N P=0.308N |P=0.363N P=0.269N P=0.516 P=0.287N |
|COCH-ARM / FISHERS | P=0.421N P=0.620N P=0.620N P=0.500N |P=0.363N P=0.288N P=0.500 P=0.288N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 16/50 (32%) 17/50 (34%) 13/50 (26%) |10/50 (20%) 3/50 (6%) 2/50 (4%) 4/50 (8%) |
|POLY-3 ADJUSTED (b)| 56.1% 40.1% 41.9% 28.9% |23.2% 7.0% 4.7% 9.7% |
|TERMINAL (d) | 7/12 (58%) 5/16 (31%) 10/21 (48%) 8/31 (26%) |5/28 (18%) 2/33 (6%) 2/34 (6%) 2/28 (7%) |
|FIRST INCIDENCE | 396 507 527 610 |461 700 738 (T) 586 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.080N P=0.019N* P<0.001N** |P=0.026N* P=0.026N* P=0.010N* P=0.086N |
|POLY 3 | P=0.006N** P=0.097N P=0.128N P=0.007N** |P=0.025N* P=0.034N* P=0.013N* P=0.082N |
|POLY 1.5 | P=0.011N* P=0.088N P=0.119N P=0.010N* |P=0.024N* P=0.036N* P=0.013N* P=0.077N |
|POLY 6 | P=0.003N** P=0.102N P=0.139N P=0.003N** |P=0.027N* P=0.030N* P=0.012N* P=0.089N |
|LOGISTIC REGRESSION| P=0.009N** P=0.084N P=0.100N P=0.013N* |P=0.026N* P=0.037N* P=0.016N* P=0.075N |
|COCH-ARM / FISHERS | P=0.020N* P=0.076N P=0.111N P=0.019N* |P=0.026N* P=0.036N* P=0.014N* P=0.074N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 9/50 (18%) 8/50 (16%) 7/50 (14%) |3/50 (6%) 3/50 (6%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 28.8% 23.0% 20.0% 15.6% |7.2% 7.0% 0.0% 2.4% |
|TERMINAL (d) | 1/12 (8%) 2/16 (13%) 4/21 (19%) 3/31 (10%) |1/28 (4%) 2/33 (6%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 396 450 527 544 |543 700 --- 571 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.017N* P=0.338N P=0.144N P=0.032N* |P=0.080N P=0.598N P=0.101N P=0.298N |
|POLY 3 | P=0.071N P=0.365N P=0.249N P=0.107N |P=0.083N P=0.650N P=0.113N P=0.309N |
|POLY 1.5 | P=0.088N P=0.343N P=0.239N P=0.128N |P=0.083N P=0.659N P=0.116N P=0.306N |
|POLY 6 | P=0.050N P=0.387N P=0.259N P=0.081N |P=0.084N P=0.632N P=0.109N P=0.314N |
|LOGISTIC REGRESSION| P=0.143N P=0.286N P=0.234N P=0.224N |P=0.085N P=0.657N P=0.123N P=0.306N |
|COCH-ARM / FISHERS | P=0.108N P=0.312N P=0.227N P=0.154N |P=0.084N P=0.661N P=0.121N P=0.309N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |4/50 (8%) 6/50 (12%) 4/50 (8%) 8/50 (16%) |
|POLY-3 ADJUSTED (b)| |9.6% 13.8% 9.2% 18.8% |
|TERMINAL (d) | |3/28 (11%) 5/33 (15%) 2/34 (6%) 5/28 (18%) |
|FIRST INCIDENCE | |573 535 647 444 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.188 P=0.456 P=0.551N P=0.194 |
|POLY 3 | |P=0.190 P=0.395 P=0.622N P=0.184 |
|POLY 1.5 | |P=0.188 P=0.379 P=0.632N P=0.183 |
|POLY 6 | |P=0.190 P=0.422 P=0.606N P=0.182 |
|LOGISTIC REGRESSION| |P=0.181 P=0.380 P=0.627N P=0.178 |
|COCH-ARM / FISHERS | |P=0.182 P=0.370 P=0.643N P=0.178 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 27/50 (54%) 16/50 (32%) 27/48 (56%) |10/50 (20%) 14/49 (29%) 14/50 (28%) 9/50 (18%) |
|POLY-3 ADJUSTED (b)| 30.6% 62.4% 41.5% 61.2% |23.7% 32.8% 31.9% 21.6% |
|TERMINAL (d) | 4/12 (33%) 7/16 (44%) 13/21 (62%) 18/30 (60%) |6/28 (21%) 12/33 (36%) 12/34 (35%) 6/28 (21%) |
|FIRST INCIDENCE | 600 428 666 605 |585 535 544 605 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.322N P=0.014 * P=0.479N P=0.390 |P=0.438N P=0.391 P=0.412 P=0.512N |
|POLY 3 | P=0.021 * P=0.002 ** P=0.217 P=0.003 ** |P=0.442N P=0.245 P=0.270 P=0.509N |
|POLY 1.5 | P=0.013 * P=0.002 ** P=0.235 P<0.001 ** |P=0.433N P=0.228 P=0.257 P=0.503N |
|POLY 6 | P=0.046 * P=0.004 ** P=0.192 P=0.010 * |P=0.465N P=0.277 P=0.290 P=0.524N |
|LOGISTIC REGRESSION| P=0.039 * P=0.002 ** P=0.296 P=0.006 ** |P=0.445N P=0.260 P=0.283 P=0.511N |
|COCH-ARM / FISHERS | P=0.011 * P=0.002 ** P=0.252 P<0.001 ** |P=0.434N P=0.224 P=0.241 P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/47 (19%) 3/45 (7%) 0/47 (0%) 0/46 (0%) |1/46 (2%) 0/44 (0%) 0/41 (0%) 0/47 (0%) |
|POLY-3 ADJUSTED (b)| 24.8% 9.1% 0.0% 0.0% |2.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/12 (25%) 1/14 (7%) 0/20 (0%) 0/28 (0%) |0/25 (0%) 0/29 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 681 544 --- --- |704 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.059N P<0.001N** P<0.001N** |P=0.184N P=0.471N P=0.477N P=0.513N |
|POLY 3 | P<0.001N** P=0.076N P<0.001N** P<0.001N** |P=0.199N P=0.498N P=0.518N P=0.499N |
|POLY 1.5 | P<0.001N** P=0.072N P<0.001N** P<0.001N** |P=0.194N P=0.504N P=0.521N P=0.498N |
|POLY 6 | P<0.001N** P=0.082N P<0.001N** P<0.001N** |P=0.206N P=0.489N P=0.514N P=0.502N |
|LOGISTIC REGRESSION| P<0.001N** P=0.084N P=0.002N** P<0.001N** |P=0.189N P=0.503N P=0.519N P=0.498N |
|COCH-ARM / FISHERS | P<0.001N** P=0.070N P<0.001N** P<0.001N** |P=0.189N P=0.511N P=0.529N P=0.495N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 8/50 (16%) 3/49 (6%) 6/50 (12%) |35/50 (70%) 28/50 (56%) 34/50 (68%) 32/50 (64%) |
|POLY-3 ADJUSTED (b)| 18.3% 21.7% 7.8% 13.5% |76.0% 61.5% 75.4% 68.9% |
|TERMINAL (d) | 3/12 (25%) 6/16 (38%) 1/21 (5%) 3/31 (10%) |23/28 (82%) 19/33 (58%) 27/34 (79%) 19/28 (68%) |
|FIRST INCIDENCE | 579 563 583 614 |475 392 563 444 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.027N* P=0.587N P=0.080N P=0.117N |P=0.456N P=0.040N* P=0.151N P=0.385N |
|POLY 3 | P=0.171N P=0.467 P=0.149N P=0.384N |P=0.425N P=0.093N P=0.576N P=0.291N |
|POLY 1.5 | P=0.207N P=0.481 P=0.157N P=0.437N |P=0.424N P=0.104N P=0.548N P=0.304N |
|POLY 6 | P=0.122N P=0.454 P=0.135N P=0.308N |P=0.443N P=0.073N P=0.594N P=0.286N |
|LOGISTIC REGRESSION| P=0.155N P=0.465 P=0.154N P=0.403N |P=0.440N P=0.092N P=0.410N P=0.335N |
|COCH-ARM / FISHERS | P=0.252N P=0.500 P=0.167N P=0.500N |P=0.447N P=0.107N P=0.500N P=0.335N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 13/50 (26%) 15/49 (31%) 21/50 (42%) |24/50 (48%) 21/50 (42%) 26/50 (52%) 27/50 (54%) |
|POLY-3 ADJUSTED (b)| 53.8% 33.2% 36.0% 45.9% |53.9% 47.5% 56.8% 58.7% |
|TERMINAL (d) | 6/12 (50%) 3/16 (19%) 8/21 (38%) 13/31 (42%) |16/28 (57%) 15/33 (46%) 19/34 (56%) 16/28 (57%) |
|FIRST INCIDENCE | 593 534 360 544 |475 620 451 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.021N* P=0.054N P=0.029N* P=0.010N* |P=0.224 P=0.172N P=0.442N P=0.356 |
|POLY 3 | P=0.321N P=0.043N* P=0.071N P=0.299N |P=0.251 P=0.348N P=0.472 P=0.397 |
|POLY 1.5 | P=0.402N P=0.043N* P=0.086N P=0.386N |P=0.240 P=0.362N P=0.447 P=0.381 |
|POLY 6 | P=0.227N P=0.045N* P=0.061N P=0.203N |P=0.251 P=0.305N P=0.515 P=0.406 |
|LOGISTIC REGRESSION| P=0.384N P=0.054N P=0.110N P=0.278N |P=0.205 P=0.309N P=0.455 P=0.344 |
|COCH-ARM / FISHERS | P=0.509N P=0.046N* P=0.121N P=0.500N |P=0.205 P=0.344N P=0.421 P=0.345 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/49 (6%) 1/50 (2%) |1/50 (2%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 7.7% 2.3% |2.4% 4.7% 0.0% 2.5% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) |0/28 (0%) 2/33 (6%) 0/34 (0%) 1/28 (4%) |
|FIRST INCIDENCE | --- 708 572 736 (T) |698 738 (T) --- 738 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.339 P=0.520 P=0.127 P=0.689 |P=0.416N P=0.557 P=0.489N P=0.747 |
|POLY 3 | P=0.284 P=0.494 P=0.124 P=0.530 |P=0.410N P=0.513 P=0.492N P=0.758 |
|POLY 1.5 | P=0.247 P=0.496 P=0.120 P=0.516 |P=0.410N P=0.504 P=0.496N P=0.760 |
|POLY 6 | P=0.344 P=0.493 P=0.133 P=0.551 |P=0.412N P=0.527 P=0.486N P=0.754 |
|LOGISTIC REGRESSION| P=0.204 P=0.493 P=0.111 P=0.689 |P=0.418N P=0.530 P=0.496N P=0.758 |
|COCH-ARM / FISHERS | P=0.208 P=0.500 P=0.117 P=0.500 |P=0.411N P=0.500 P=0.500N P=0.753N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 7/50 (14%) 7/50 (14%) 4/50 (8%) | |
|POLY-3 ADJUSTED (b)| 18.2% 18.5% 17.9% 9.1% | |
|TERMINAL (d) | 5/12 (42%) 3/16 (19%) 4/21 (19%) 3/31 (10%) | |
|FIRST INCIDENCE | 396 435 572 660 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.020N* P=0.497N P=0.337N P=0.022N* | |
|POLY 3 | P=0.141N P=0.606 P=0.602N P=0.188N | |
|POLY 1.5 | P=0.178N P=0.606 P=0.609N P=0.222N | |
|POLY 6 | P=0.093N P=0.617 P=0.580N P=0.142N | |
|LOGISTIC REGRESSION| P=0.175N P=0.603 P=0.599N P=0.203N | |
|COCH-ARM / FISHERS | P=0.222N P=0.613N P=0.613N P=0.262N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 42/50 (84%) 40/50 (80%) 47/50 (94%) 47/50 (94%) | |
|POLY-3 ADJUSTED (b)| 92.0% 86.0% 96.8% 97.0% | |
|TERMINAL (d) | 12/12 (100%) 13/16 (81%) 20/21 (95%) 30/31 (97%) | |
|FIRST INCIDENCE | 396 410 443 518 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.004N** P=0.306N P=0.279N P<0.001N** | |
|POLY 3 | P=0.045 * P=0.245N P=0.238 P=0.224 | |
|POLY 1.5 | P=0.021 * P=0.313N P=0.140 P=0.122 | |
|POLY 6 | P=0.144 P=0.155N P=0.543 P=0.541 | |
|LOGISTIC REGRESSION| P=0.048 * P=0.456N P=0.098 P=0.290 | |
|COCH-ARM / FISHERS | P=0.020 * P=0.398N P=0.100 P=0.100 | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 5.2% 0.0% | |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 0/31 (0%) | |
|FIRST INCIDENCE | 561 --- 666 --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.143N P=0.238N P=0.608N P=0.152N | |
|POLY 3 | P=0.209N P=0.247N P=0.691N P=0.208N | |
|POLY 1.5 | P=0.227N P=0.243N P=0.692N P=0.221N | |
|POLY 6 | P=0.183N P=0.251N P=0.685N P=0.189N | |
|LOGISTIC REGRESSION| P=0.237N P=0.236N P=0.692N P=0.255N | |
|COCH-ARM / FISHERS | P=0.249N P=0.247N P=0.691N P=0.247N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 38/50 (76%) 34/50 (68%) 32/50 (64%) 26/49 (53%) | |
|POLY-3 ADJUSTED (b)| 79.2% 73.1% 67.9% 54.9% | |
|TERMINAL (d) | 8/12 (67%) 10/16 (63%) 10/21 (48%) 15/30 (50%) | |
|FIRST INCIDENCE | 396 410 360 213 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.260N P=0.072N P<0.001N** | |
|POLY 3 | P=0.004N** P=0.316N P=0.144N P=0.008N** | |
|POLY 1.5 | P=0.006N** P=0.288N P=0.141N P=0.010N* | |
|POLY 6 | P=0.002N** P=0.351N P=0.147N P=0.005N** | |
|LOGISTIC REGRESSION| P=0.033N* P=0.221N P=0.146N P=0.055N | |
|COCH-ARM / FISHERS | P=0.010N* P=0.252N P=0.138N P=0.014N* | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Cyst Epithelial Inclusion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 0.0% 4.6% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 736 (T) --- 707 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.310 P=0.557 (e) P=0.428 |(e) (e) (e) (e) |
|POLY 3 | P=0.171 P=0.493 (e) P=0.273 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.160 P=0.496 (e) P=0.256 |(e) (e) (e) (e) |
|POLY 6 | P=0.190 P=0.491 (e) P=0.301 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.235 P=0.557 (e) P=0.318 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.149 P=0.500 (e) P=0.247 |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Epidermis |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) 3/50 (6%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 7.9% 6.9% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 3/21 (14%) 3/31 (10%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 726 736 (T) 736 (T) |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.201 P=0.525 P=0.232 P=0.328 |(e) (e) (e) (e) |
|POLY 3 | P=0.065 P=0.493 P=0.121 P=0.148 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.054 P=0.496 P=0.120 P=0.134 |(e) (e) (e) (e) |
|POLY 6 | P=0.088 P=0.492 P=0.124 P=0.172 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.155 P=0.506 P=0.232 P=0.328 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.043 * P=0.500 P=0.121 P=0.121 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Epidermis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |1/50 (2%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 2.7% 0.0% 0.0% 0.0% |2.4% 0.0% 4.6% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) |1/28 (4%) 0/33 (0%) 1/34 (3%) 0/28 (0%) |
|FIRST INCIDENCE | 663 --- --- --- |738 (T) --- 600 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.168N P=0.521N P=0.507N P=0.448N |P=0.496N P=0.467N P=0.553 P=0.500N |
|POLY 3 | P=0.194N P=0.508N P=0.497N P=0.471N |P=0.518N P=0.492N P=0.519 P=0.502N |
|POLY 1.5 | P=0.191N P=0.505N P=0.499N P=0.484N |P=0.507N P=0.497N P=0.510 P=0.501N |
|POLY 6 | P=0.198N P=0.511N P=0.494N P=0.451N |P=0.539N P=0.483N P=0.532 P=0.505N |
|LOGISTIC REGRESSION| P=0.183N P=0.502N P=0.499N P=0.509N |P=0.500N (e) P=0.503 (e) |
|COCH-ARM / FISHERS | P=0.185N P=0.500N P=0.500N P=0.500N |P=0.500N P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 3/50 (6%) 1/50 (2%) |1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 13.2% 8.3% 7.8% 2.3% |2.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/12 (33%) 2/16 (13%) 2/21 (10%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 603 723 645 736 (T) |696 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.005N** P=0.231N P=0.158N P=0.007N** |P=0.194N P=0.473N P=0.494N P=0.531N |
|POLY 3 | P=0.046N* P=0.379N P=0.345N P=0.071N |P=0.192N P=0.493N P=0.492N P=0.503N |
|POLY 1.5 | P=0.057N P=0.370N P=0.350N P=0.084N |P=0.188N P=0.497N P=0.496N P=0.501N |
|POLY 6 | P=0.033N* P=0.387N P=0.331N P=0.055N |P=0.199N P=0.485N P=0.487N P=0.506N |
|LOGISTIC REGRESSION| P=0.027N* P=0.361N P=0.324N P=0.046N* |P=0.184N P=0.498N P=0.497N P=0.501N |
|COCH-ARM / FISHERS | P=0.071N P=0.357N P=0.357N P=0.102N |P=0.185N P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |9/50 (18%) 12/50 (24%) 6/50 (12%) 10/50 (20%) |
|POLY-3 ADJUSTED (b)| 10.3% 0.0% 2.6% 0.0% |21.1% 27.6% 13.6% 23.3% |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 0/31 (0%) |5/28 (18%) 10/33 (30%) 3/34 (9%) 6/28 (21%) |
|FIRST INCIDENCE | 396 --- 593 --- |391 535 399 417 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.010N* P=0.058N P=0.138N P=0.023N* |P=0.430N P=0.450 P=0.200N P=0.499 |
|POLY 3 | P=0.016N* P=0.068N P=0.177N P=0.046N* |P=0.419N P=0.328 P=0.261N P=0.508 |
|POLY 1.5 | P=0.018N* P=0.065N P=0.179N P=0.053N |P=0.422N P=0.311 P=0.274N P=0.507 |
|POLY 6 | P=0.013N* P=0.070N P=0.171N P=0.037N* |P=0.422N P=0.362 P=0.242N P=0.502 |
|LOGISTIC REGRESSION| P=0.025N* P=0.058N P=0.186N P=0.080N |P=0.435N P=0.325 P=0.298N P=0.500 |
|COCH-ARM / FISHERS | P=0.021N* P=0.059N P=0.181N P=0.059N |P=0.435N P=0.312 P=0.288N P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 2/50 (4%) 2/50 (4%) |1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 5.2% 4.6% |2.4% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 690 --- 617 709 |573 --- --- 634 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.504N P=0.229N P=0.631N P=0.435N |P=0.623N P=0.495N P=0.491N P=0.759N |
|POLY 3 | P=0.495 P=0.245N P=0.685N P=0.639N |P=0.627N P=0.495N P=0.494N P=0.758 |
|POLY 1.5 | P=0.462 P=0.242N P=0.689N P=0.665N |P=0.625N P=0.499N P=0.497N P=0.760 |
|POLY 6 | P=0.544 P=0.248N P=0.675N P=0.599N |P=0.632 P=0.487N P=0.489N P=0.755 |
|LOGISTIC REGRESSION| P=0.499 P=0.243N P=0.688N P=0.581N |P=0.613 P=0.472N P=0.513N P=0.758 |
|COCH-ARM / FISHERS | P=0.426 P=0.247N P=0.691N P=0.691N |P=0.625N P=0.500N P=0.500N P=0.753N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 4/50 (8%) 3/50 (6%) 2/50 (4%) |1/50 (2%) 0/50 (0%) 3/50 (6%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 25.6% 10.7% 7.6% 4.5% |2.4% 0.0% 6.8% 2.4% |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 579 544 360 561 |731 --- 451 684 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001N** P=0.084N P=0.028N* P=0.002N** |P=0.330 P=0.468N P=0.335 P=0.750 |
|POLY 3 | P=0.002N** P=0.079N P=0.029N* P=0.006N** |P=0.336 P=0.492N P=0.332 P=0.760 |
|POLY 1.5 | P=0.003N** P=0.076N P=0.031N* P=0.009N** |P=0.341 P=0.497N P=0.320 P=0.761 |
|POLY 6 | P<0.001N** P=0.082N P=0.026N* P=0.004N** |P=0.326 P=0.484N P=0.350 P=0.758 |
|LOGISTIC REGRESSION| P=0.006N** P=0.081N P=0.037N* P=0.013N* |P=0.333 P=0.475N P=0.282 P=0.760 |
|COCH-ARM / FISHERS | P=0.005N** P=0.074N P=0.036N* P=0.014N* |P=0.343 P=0.500N P=0.309 P=0.753N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 8/50 (16%) 4/50 (8%) 3/50 (6%) |3/50 (6%) 1/50 (2%) 3/50 (6%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 20.5% 21.1% 9.9% 6.8% |7.2% 2.3% 6.8% 7.2% |
|TERMINAL (d) | 0/12 (0%) 2/16 (13%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 579 544 360 561 |543 620 451 605 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.008N** P=0.579N P=0.156N P=0.022N* |P=0.427 P=0.280N P=0.625N P=0.644 |
|POLY 3 | P=0.019N* P=0.586 P=0.156N P=0.062N |P=0.444 P=0.294N P=0.636N P=0.662 |
|POLY 1.5 | P=0.026N* P=0.594 P=0.164N P=0.077N |P=0.445 P=0.302N P=0.647N P=0.662 |
|POLY 6 | P=0.012N* P=0.583 P=0.147N P=0.045N* |P=0.439 P=0.280N P=0.619N P=0.659 |
|LOGISTIC REGRESSION| P=0.044N* P=0.589 P=0.184N P=0.097N |P=0.426 P=0.302N P=0.638 P=0.662 |
|COCH-ARM / FISHERS | P=0.037N* P=0.607N P=0.178N P=0.100N |P=0.442 P=0.309N P=0.661N P=0.661N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia Basal Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 5.2% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 2/21 (10%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 736 (T) --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.572 (e) P=0.367 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.468 (e) P=0.241 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.425 (e) P=0.239 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.531 (e) P=0.245 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.367 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.375 (e) P=0.247 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 3/50 (6%) 4/50 (8%) 1/50 (2%) |2/50 (4%) 0/50 (0%) 3/50 (6%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 20.8% 8.1% 10.0% 2.3% |4.8% 0.0% 6.8% 2.4% |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 0/31 (0%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 600 544 527 561 |475 --- 451 684 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.004N** P=0.101N P=0.138N P=0.003N** |P=0.562 P=0.227N P=0.525 P=0.513N |
|POLY 3 | P=0.006N** P=0.104N P=0.153N P=0.008N** |P=0.563 P=0.232N P=0.526 P=0.508N |
|POLY 1.5 | P=0.009N** P=0.102N P=0.164N P=0.011N* |P=0.570 P=0.236N P=0.514 P=0.504N |
|POLY 6 | P=0.004N** P=0.105N P=0.137N P=0.005N** |P=0.551 P=0.224N P=0.544 P=0.514N |
|LOGISTIC REGRESSION| P=0.015N* P=0.109N P=0.176N P=0.013N* |P=0.553 P=0.219N P=0.466 P=0.504N |
|COCH-ARM / FISHERS | P=0.013N* P=0.100N P=0.178N P=0.015N* |P=0.574N P=0.247N P=0.500 P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Glandular: Epithelium |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |1/50 (2%) 2/50 (4%) 1/50 (2%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 5.3% 2.7% 0.0% 4.5% |2.4% 4.6% 2.3% 4.8% |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 1/31 (3%) |0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 603 614 --- 518 |696 620 733 572 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.349N P=0.480N P=0.180N P=0.498N |P=0.405 P=0.542 P=0.733N P=0.480 |
|POLY 3 | P=0.486N P=0.512N P=0.234N P=0.637N |P=0.435 P=0.517 P=0.752N P=0.503 |
|POLY 1.5 | P=0.494N P=0.507N P=0.236N P=0.663N |P=0.432 P=0.507 P=0.756N P=0.502 |
|POLY 6 | P=0.471N P=0.515N P=0.231N P=0.597N |P=0.437 P=0.534 P=0.746N P=0.502 |
|LOGISTIC REGRESSION| P=0.528N P=0.500N P=0.236N P=0.665 |P=0.423 P=0.499 P=0.752N P=0.497 |
|COCH-ARM / FISHERS | P=0.500N P=0.500N P=0.247N P=0.691N |P=0.426 P=0.500 P=0.753N P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes: Germinal Epithelium |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 4/50 (8%) 4/50 (8%) | |
|POLY-3 ADJUSTED (b)| 5.3% 5.3% 10.4% 9.1% | |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 2/21 (10%) 2/31 (7%) | |
|FIRST INCIDENCE | 733 507 702 621 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.467 P=0.663N P=0.537 P=0.655N | |
|POLY 3 | P=0.247 P=0.695 P=0.347 P=0.415 | |
|POLY 1.5 | P=0.212 P=0.694 P=0.343 P=0.378 | |
|POLY 6 | P=0.309 P=0.692N P=0.360 P=0.473 | |
|LOGISTIC REGRESSION| P=0.209 P=0.688N P=0.406 P=0.455 | |
|COCH-ARM / FISHERS | P=0.176 P=0.691N P=0.339 P=0.339 | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes: Interstitial Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 10/50 (20%) 6/50 (12%) 5/50 (10%) | |
|POLY-3 ADJUSTED (b)| 24.7% 24.1% 14.6% 11.1% | |
|TERMINAL (d) | 2/12 (17%) 0/16 (0%) 0/21 (0%) 1/31 (3%) | |
|FIRST INCIDENCE | 435 435 360 518 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.024N* P=0.571 P=0.166N P=0.033N* | |
|POLY 3 | P=0.033N* P=0.581N P=0.192N P=0.084N | |
|POLY 1.5 | P=0.043N* P=0.590N P=0.197N P=0.104N | |
|POLY 6 | P=0.022N* P=0.559N P=0.183N P=0.060N | |
|LOGISTIC REGRESSION| P=0.124N P=0.545N P=0.217N P=0.192N | |
|COCH-ARM / FISHERS | P=0.058N P=0.598N P=0.207N P=0.131N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/46 (0%) 0/49 (0%) 0/47 (0%) |0/48 (0%) 1/44 (2%) 3/48 (6%) 0/47 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 2.5% 7.3% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/15 (0%) 0/20 (0%) 0/28 (0%) |0/26 (0%) 0/31 (0%) 3/33 (9%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- 392 738 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.422 P=0.496 P=0.165 (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.413 P=0.501 P=0.128 (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.414 P=0.492 P=0.124 (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.407 P=0.514 P=0.136 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.406 P=0.710 P=0.165 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.413 P=0.478 P=0.121 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Ectopic Parathyroid Gland |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/46 (2%) 0/49 (0%) 0/47 (0%) |0/48 (0%) 0/44 (0%) 0/48 (0%) 2/47 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.0% 0.0% 0.0% |0.0% 0.0% 0.0% 5.1% |
|TERMINAL (d) | 0/12 (0%) 0/15 (0%) 0/20 (0%) 0/28 (0%) |0/26 (0%) 0/31 (0%) 0/33 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 708 --- --- |--- --- --- 634 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.406N P=0.520 (e) (e) |P=0.050 (e) (e) P=0.222 |
|POLY 3 | P=0.506N P=0.477 (e) (e) |P=0.058 (e) (e) P=0.238 |
|POLY 1.5 | P=0.505N P=0.481 (e) (e) |P=0.058 (e) (e) P=0.236 |
|POLY 6 | P=0.502N P=0.474 (e) (e) |P=0.060 (e) (e) P=0.241 |
|LOGISTIC REGRESSION| P=0.467N P=0.475 (e) (e) |P=0.055 (e) (e) P=0.226 |
|COCH-ARM / FISHERS | P=0.503N P=0.484 (e) (e) |P=0.057 (e) (e) P=0.242 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 8/50 (16%) 21/50 (42%) 19/50 (38%) |16/50 (32%) 23/50 (46%) 27/50 (54%) 20/50 (40%) |
|POLY-3 ADJUSTED (b)| 39.8% 21.1% 50.5% 42.8% |37.8% 51.6% 60.3% 47.1% |
|TERMINAL (d) | 5/12 (42%) 3/16 (19%) 11/21 (52%) 16/31 (52%) |9/28 (32%) 19/33 (58%) 21/34 (62%) 15/28 (54%) |
|FIRST INCIDENCE | 579 507 521 619 |620 430 544 572 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.213N P=0.042N* P=0.567N P=0.049N* |P=0.168 P=0.272 P=0.113 P=0.259 |
|POLY 3 | P=0.147 P=0.055N P=0.220 P=0.477 |P=0.151 P=0.135 P=0.025 * P=0.254 |
|POLY 1.5 | P=0.107 P=0.051N P=0.213 P=0.411 |P=0.162 P=0.117 P=0.021 * P=0.263 |
|POLY 6 | P=0.223 P=0.061N P=0.234 P=0.569 |P=0.130 P=0.163 P=0.031 * P=0.233 |
|LOGISTIC REGRESSION| P=0.196 P=0.057N P=0.216 P=0.551N |P=0.148 P=0.133 P=0.030 * P=0.235 |
|COCH-ARM / FISHERS | P=0.077 P=0.050N P=0.204 P=0.338 |P=0.169 P=0.109 P=0.021 * P=0.266 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 PPM 200 PPM 400 PPM 600 PPM |0 PPM 200 PPM 400 PPM 600 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |0/50 (0%) 2/50 (4%) 0/50 (0%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| |0.0% 4.7% 0.0% 4.9% |
|TERMINAL (d) | |0/28 (0%) 2/33 (6%) 0/34 (0%) 1/28 (4%) |
|FIRST INCIDENCE | |--- 738 (T) --- 692 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.236 P=0.275 (e) P=0.226 |
|POLY 3 | |P=0.259 P=0.246 (e) P=0.236 |
|POLY 1.5 | |P=0.254 P=0.240 (e) P=0.237 |
|POLY 6 | |P=0.266 P=0.256 (e) P=0.233 |
|LOGISTIC REGRESSION| |P=0.236 P=0.275 (e) P=0.233 |
|COCH-ARM / FISHERS | |P=0.249 P=0.247 (e) P=0.247 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).