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TDMS Study 89006-04 Pathology Tables

NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96
Route: GAVAGE                                                                                                     Time: 09:06:20




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-871

       Lock Date:  11/01/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8            7            6            8                                     
    Natural Death                                      5            5            6            9                                     
    Dosing Accident                                                              2                                                  
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           37           36           32                                     
    Natural Death                                                   1                                                               
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (49)                                   
      Necrosis                                                                   2 (4%)                                             
      Perforation                                                                2 (4%)                                             
      Muscularis, Inflammation, Chronic                                          2 (4%)                                             
      Periesophageal Tissue, Inflammation, Chronic                               1 (2%)                                             
   Intestine Small, Duodenum                          (48)         (48)         (47)         (47)                                   
      Hyperplasia, Adenomatous                                                                1 (2%)                                
   Intestine Small, Jejunum                           (47)         (46)         (46)         (45)                                   
      Hyperplasia, Adenomatous                         1 (2%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)       2 (4%)                                             
   Intestine Small, Ileum                             (47)         (46)         (46)         (45)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Hyperplasia, Adenomatous                         1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Basophilic Focus                                              1 (2%)       1 (2%)                                             
      Clear Cell Focus                                              2 (4%)       1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Eosinophilic Focus                               4 (8%)       6 (12%)      5 (10%)      2 (4%)                                
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Focal, Lymphoid                     1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           10 (20%)      6 (12%)      6 (12%)      6 (12%)                               
      Mixed Cell Focus                                 2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Necrosis, Focal                                  2 (4%)       2 (4%)       2 (4%)       3 (6%)                                
      Vacuolization Cytoplasmic                        2 (4%)       6 (12%)      2 (4%)       3 (6%)                                
      Bile Duct, Hyperplasia                                                                  1 (2%)                                
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Hepatocyte, Karyomegaly                          1 (2%)                    1 (2%)       1 (2%)                                
   Mesentery                                          (10)         (12)         (9)          (10)                                   
      Hemorrhage                                       1 (10%)      2 (17%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                            1 (10%)      1 (8%)                                                          
      Fat, Necrosis                                    7 (70%)      9 (75%)      5 (56%)      5 (50%)                               
   Pancreas                                           (48)         (50)         (50)         (49)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Acinus, Atrophy, Diffuse                                      1 (2%)                    1 (2%)                                
      Acinus, Atrophy, Focal                                                     2 (4%)       1 (2%)                                
      Duct, Cyst                                                    1 (2%)       1 (2%)       3 (6%)                                
   Salivary Glands                                    (50)         (49)         (50)         (48)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (49)         (48)                                   
      Cyst                                                                       1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                          3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (49)         (50)         (48)         (49)                                   
      Edema                                            1 (2%)       1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Glands, Degeneration, Cystic, Focal              5 (10%)      1 (2%)       8 (17%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic, Focal                     2 (4%)                    1 (2%)                                             
      Thrombosis                                       1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                    3 (6%)                                             
      Cyst                                             1 (2%)       1 (2%)                                                          
      Hyperplasia, Focal                               3 (6%)       4 (8%)       1 (2%)       4 (8%)                                
      Hypertrophy, Focal                                                         2 (4%)       2 (4%)                                
   Islets, Pancreatic                                 (48)         (49)         (50)         (48)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (43)         (43)         (45)         (46)                                   
      Cyst                                             1 (2%)                                                                       
   Pituitary Gland                                    (49)         (44)         (48)         (44)                                   
      Angiectasis                                      4 (8%)       1 (2%)       4 (8%)       3 (7%)                                
      Pars Distalis, Cyst                                           1 (2%)       1 (2%)       3 (7%)                                
      Pars Distalis, Cytoplasmic Alteration, Focal                  2 (5%)       1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                8 (16%)      7 (16%)      8 (17%)      8 (18%)                               
      Rathke's Cleft, Cyst                             1 (2%)                                 3 (7%)                                
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Degeneration, Cystic, Focal                     19 (39%)     16 (32%)     14 (28%)     12 (24%)                               
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Cyst                                   7 (14%)      6 (12%)      9 (18%)      7 (14%)                               
      Follicular Cell, Hyperplasia                    21 (43%)     19 (38%)     17 (34%)     17 (34%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (49)                                   
      Degeneration, Cystic                             3 (6%)       1 (2%)       3 (6%)       3 (6%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Ovary                                              (50)         (49)         (49)         (50)                                   
      Cyst                                            10 (20%)      6 (12%)      5 (10%)     13 (26%)                               
      Hemorrhage                                                    2 (4%)       1 (2%)       4 (8%)                                
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Bilateral, Cyst                                                                         1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                2 (4%)                                             
      Cyst                                             1 (2%)       2 (4%)                                                          
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Hydrometra                                      19 (38%)     21 (42%)     13 (26%)     15 (30%)                               
      Thrombosis                                       1 (2%)       1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                42 (84%)     37 (74%)     41 (82%)     45 (90%)                               
   Vagina                                             (50)         (48)         (48)         (50)                                   
      Epithelium, Hyperplasia                          1 (2%)       3 (6%)       7 (15%)     12 (24%)                               
      Epithelium, Hyperplasia, Atypical                             1 (2%)       1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (48)                                   
      Angiectasis                                                                             1 (2%)                                
      Depletion Cellular                                                                      2 (4%)                                
      Hyperplasia                                      1 (2%)       4 (8%)       4 (8%)       4 (8%)                                
   Lymph Node                                         (8)          (7)          (4)          (6)                                    
      Iliac, Hemorrhage                                1 (13%)                                                                      
      Renal, Hemorrhage                                                                       1 (17%)                               
   Lymph Node, Mandibular                             (46)         (46)         (48)         (44)                                   
      Hemorrhage                                       1 (2%)                    2 (4%)                                             
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Infiltration Cellular, Mast Cell                                           1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (49)         (48)         (49)                                   
      Ectasia                                                       1 (2%)                    2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       4 (8%)       2 (4%)       7 (15%)      6 (12%)                               
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)                                                          
   Spleen                                             (49)         (49)         (49)         (49)                                   
      Depletion Cellular                                                         1 (2%)       1 (2%)                                
      Fibrosis, Focal                                                                         1 (2%)                                
      Hematopoietic Cell Proliferation                23 (47%)     15 (31%)     12 (24%)     17 (35%)                               
      Hyperplasia, Lymphoid                            5 (10%)      4 (8%)       8 (16%)      3 (6%)                                
   Thymus                                             (47)         (46)         (48)         (48)                                   
      Atrophy                                                       3 (7%)       1 (2%)       2 (4%)                                
      Cyst                                             3 (6%)       4 (9%)       4 (8%)       2 (4%)                                
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)       1 (2%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Edema                                                         3 (6%)       3 (6%)       1 (2%)                                
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)       2 (4%)                                
      Ulcer                                                                                   1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           2 (4%)                                                                       
      Hyperostosis                                    48 (96%)     40 (80%)     36 (72%)     43 (86%)                               
      Cranium, Fibrous Osteodystrophy                                            1 (2%)                                             
      Femur, Fibrous Osteodystrophy                                 1 (2%)       2 (4%)       2 (4%)                                
      Femur, Osteopetrosis                                          1 (2%)                                                          
   Skeletal Muscle                                    (47)         (50)         (49)         (50)                                   
      Hemorrhage, Focal                                                          1 (2%)                                             
      Inflammation, Suppurative                                                               1 (2%)                                
      Regeneration                                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Atrophy, Focal                                   2 (4%)       4 (8%)       1 (2%)                                             
      Vacuolization Cytoplasmic                                                               1 (2%)                                
      Meninges, Inflammation, Chronic                  1 (2%)                                 1 (2%)                                
   Spinal Cord                                        (2)                       (1)          (4)                                    
      Cyst Epithelial Inclusion                        1 (50%)                                1 (25%)                               
      Hemorrhage, Focal                                                          1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                    2 (4%)                                             
      Hemorrhage                                                    3 (6%)       2 (4%)       3 (6%)                                
      Hyperplasia, Histiocytic                         2 (4%)       3 (6%)       1 (2%)       1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Pigmentation                                                  1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              2 (4%)       1 (2%)       2 (4%)                                
      Mediastinum, Inflammation, Chronic                                         1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Mucosa, Glands, Dilatation, Focal                3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Fibrosis                                         1 (50%)                                                                      
      Cornea, Inflammation, Chronic                                              1 (100%)                                           
   Harderian Gland                                    (5)          (2)          (2)          (1)                                    
      Hyperplasia, Focal                               1 (20%)                                                                      
      Inflammation, Chronic, Focal                     1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Congestion                                                                              1 (2%)                                
      Infarct                                          1 (2%)                    1 (2%)       1 (2%)                                
      Metaplasia, Focal, Osseous                                    3 (6%)       2 (4%)                                             
      Nephropathy                                     35 (70%)     33 (66%)     39 (78%)     33 (67%)                               
      Pelvis, Dilatation                                                         1 (2%)       1 (2%)                                
      Renal Tubule, Accumulation, Hyaline Droplet                   1 (2%)       1 (2%)                                             
      Renal Tubule, Atrophy                                                                   1 (2%)                                
      Renal Tubule, Dilatation                         1 (2%)                    1 (2%)       2 (4%)                                
      Renal Tubule, Mineralization                                  1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Necrosis                                        1 (2%)                                                          
      Renal Tubule, Pigmentation                       1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10            3            5           10                                     
    Moribund Sacrifice                                 9           11            9            6                                     
    Dosing Accident                                                 1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           35           35           34                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Necrosis                                                                   1 (2%)                                             
      Perforation                                                   1 (2%)                                                          
      Muscularis, Inflammation, Chronic                             1 (2%)       1 (2%)                                             
   Gallbladder                                        (44)         (46)         (45)         (42)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
   Intestine Small, Duodenum                          (46)         (48)         (48)         (46)                                   
      Hyperplasia, Adenomatous                                                                1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 1 (2%)       1 (2%)                                                          
      Clear Cell Focus                                 1 (2%)       6 (12%)      2 (4%)       2 (4%)                                
      Congestion                                                    1 (2%)                                                          
      Degeneration, Cystic                                                                    1 (2%)                                
      Eosinophilic Focus                               6 (12%)      7 (14%)      3 (6%)       3 (6%)                                
      Hemorrhage                                       2 (4%)                                 1 (2%)                                
      Inflammation, Chronic                           45 (90%)     43 (86%)     38 (76%)     41 (82%)                               
      Inflammation, Focal                                           1 (2%)                                                          
      Mixed Cell Focus                                 3 (6%)       3 (6%)       6 (12%)      4 (8%)                                
      Necrosis, Focal                                  2 (4%)       2 (4%)       3 (6%)       8 (16%)                               
      Pigmentation, Focal                              1 (2%)                                                                       
      Vacuolization Cytoplasmic                        6 (12%)      7 (14%)      2 (4%)       6 (12%)                               
      Bile Duct, Cyst                                  1 (2%)       1 (2%)       2 (4%)                                             
      Bile Duct, Hyperplasia                          29 (58%)     31 (62%)     33 (66%)     29 (58%)                               
      Centrilobular, Necrosis                                       1 (2%)                                                          
      Hepatocyte, Karyomegaly                         37 (74%)     32 (64%)     31 (62%)     32 (64%)                               
   Mesentery                                          (3)          (5)          (1)          (1)                                    
      Inflammation, Chronic                                         1 (20%)                                                         
      Thrombosis                                                    1 (20%)                                                         
      Artery, Inflammation, Chronic                    1 (33%)      1 (20%)                                                         
      Fat, Necrosis                                    1 (33%)                   1 (100%)                                           
   Pancreas                                           (48)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
      Acinus, Atrophy, Diffuse                                                                1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy, Focal                                                     2 (4%)                                             
      Duct, Cyst                                       1 (2%)       1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (50)         (47)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Diverticulum                                                               1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                                         3 (6%)                                                          
      Epithelium, Hyperplasia                          3 (6%)       2 (4%)       5 (10%)      3 (6%)                                
   Stomach, Glandular                                 (49)         (50)         (50)         (47)                                   
      Edema                                                                      1 (2%)                                             
      Erosion                                                                                 1 (2%)                                
      Hyperplasia, Adenomatous                                                   1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Mineralization                                   1 (2%)       1 (2%)       3 (6%)       2 (4%)                                
      Necrosis                                                                                1 (2%)                                
      Glands, Degeneration, Cystic, Focal                           4 (8%)       4 (8%)       1 (2%)                                
   Tooth                                              (2)          (2)          (2)          (1)                                    
      Developmental Malformation                       2 (100%)     2 (100%)     1 (50%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (49)         (50)         (49)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Mineralization                                                                          2 (4%)                                
      Thrombosis                                       1 (2%)                                                                       
      Artery, Inflammation, Chronic                    1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Cytoplasmic Alteration, Focal                    3 (6%)      10 (20%)      6 (12%)     18 (36%)                               
      Hyperplasia, Focal                                            2 (4%)       7 (14%)      3 (6%)                                
      Hypertrophy, Focal                               7 (14%)     11 (22%)      9 (18%)     11 (22%)                               
      Capsule, Hyperplasia, Focal                      2 (4%)       2 (4%)       3 (6%)       2 (4%)                                
   Adrenal Medulla                                    (48)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Islets, Pancreatic                                 (48)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       1 (2%)                    1 (2%)                                
   Parathyroid Gland                                  (50)         (45)         (48)         (46)                                   
      Cyst                                             3 (6%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (47)         (43)         (48)         (43)                                   
      Pars Distalis, Cyst                                           1 (2%)       3 (6%)       2 (5%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia, Focal                1 (2%)                    1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Degeneration, Cystic, Focal                      7 (14%)     11 (22%)     14 (28%)     10 (20%)                               
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      C-Cell, Hyperplasia                                                                     1 (2%)                                
      Follicle, Cyst                                   5 (10%)      5 (10%)      6 (12%)      6 (12%)                               
      Follicular Cell, Hyperplasia                    13 (26%)     14 (28%)      7 (14%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                                            2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Spermatocele                                                               1 (2%)                                             
   Preputial Gland                                    (50)         (49)         (47)         (50)                                   
      Degeneration, Cystic                            44 (88%)     41 (84%)     42 (89%)     48 (96%)                               
      Inflammation, Chronic                            2 (4%)       2 (4%)                                                          
   Prostate                                           (49)         (49)         (50)         (49)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Angiectasis                                                                             1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Germinal Epithelium, Degeneration                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       7 (14%)      1 (2%)       1 (2%)                                
   Lymph Node                                         (2)          (4)          (5)          (2)                                    
      Mediastinal, Hyperplasia, Lymphoid                                         1 (20%)                                            
      Mediastinal, Necrosis                                                      1 (20%)                                            
      Pancreatic, Hyperplasia, Lymphoid                             1 (25%)                                                         
   Lymph Node, Mandibular                             (45)         (46)         (44)         (47)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                 2 (4%)                                
   Lymph Node, Mesenteric                             (46)         (50)         (50)         (50)                                   
      Ectasia                                                       3 (6%)       1 (2%)       2 (4%)                                
      Hemorrhage                                      17 (37%)     21 (42%)     12 (24%)     13 (26%)                               
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            3 (7%)       1 (2%)       1 (2%)       3 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Chronic                            2 (4%)                                                                       
   Spleen                                             (48)         (50)         (50)         (49)                                   
      Angiectasis                                                                1 (2%)                                             
      Congestion                                       3 (6%)       1 (2%)                    2 (4%)                                
      Depletion Cellular                                                         2 (4%)                                             
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematopoietic Cell Proliferation                18 (38%)     16 (32%)     12 (24%)     14 (29%)                               
      Hyperplasia, Lymphoid                            3 (6%)                    3 (6%)                                             
      Necrosis, Focal                                               1 (2%)                                                          
      Capsule, Fibrosis                                             1 (2%)                                                          
   Thymus                                             (42)         (45)         (46)         (42)                                   
      Atrophy                                          3 (7%)                    2 (4%)       3 (7%)                                
      Cyst                                             2 (5%)       6 (13%)      8 (17%)      7 (17%)                               
      Necrosis                                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (49)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        2 (4%)                                                                       
      Edema                                            1 (2%)       1 (2%)       7 (14%)      3 (6%)                                
      Infiltration Cellular, Mast Cell                                           1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
      Ulcer                                                         2 (4%)                                                          
      Subcutaneous Tissue, Edema                                                              1 (2%)                                
      Subcutaneous Tissue, Foreign Body                                          1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage                  1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Suppurative                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                    40 (80%)     26 (52%)     36 (72%)     31 (62%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 89006-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   AZT/INTERFERON A/INTERFERON AD                              Date: 08/14/96  
Route: GAVAGE                                                                                                     Time: 09:06:20  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      30 MG/KG     60 MG/KG     120MG/KG                                  
                                                   CONTROL       5000 U       5000 U       5000 U                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       2 (4%)       1 (2%)                                                          
      Foreign Body                                                  2 (4%)                                                          
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)                                
      Hyperplasia, Histiocytic                         4 (8%)       1 (2%)       1 (2%)       2 (4%)                                
      Pigmentation                                                  1 (2%)                                                          
      Thrombosis                                                                              1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
      Mediastinum, Inflammation, Chronic                            1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Suppurative                        2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)          (1)                                                 
      External Ear, Inflammation, Chronic                           1 (100%)                                                        
   Eye                                                (1)          (6)                       (2)                                    
      Cataract                                                      2 (33%)                   1 (50%)                               
      Fibrosis                                                      1 (17%)                                                         
      Cornea, Inflammation, Chronic                    1 (100%)     5 (83%)                   2 (100%)                              
   Harderian Gland                                    (4)          (9)          (4)          (4)                                    
      Hyperplasia, Focal                               1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Cyst                                             3 (6%)       3 (6%)                    2 (4%)                                
      Infarct                                          1 (2%)       5 (10%)      4 (8%)                                             
      Metaplasia, Focal, Osseous                                    1 (2%)                                                          
      Nephropathy                                     49 (100%)    50 (100%)    47 (94%)     44 (88%)                               
      Renal Tubule, Accumulation, Hyaline Droplet      1 (2%)                                                                       
      Renal Tubule, Dilatation                                                   1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                                                        2 (4%)                                
      Renal Tubule, Necrosis                                                     1 (2%)                                             
      Renal Tubule, Pigmentation                       1 (2%)                                                                       
   Urethra                                            (3)          (2)          (2)          (6)                                    
      Inflammation, Chronic                                                                   1 (17%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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                             ----------              END OF REPORT             ----------                                           
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