TDMS Study 89006-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst AZT DATE: 06/03/96
EXPERIMENT: 89006 TEST: 06 TIME: 19:43:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-85225 ROUTE: GAVAGE NTP C#: C88072
PATHOLOGIST: R.B. THOMPSON CAS: 30516-87-1
------------------------------------------------------------------------------------------------------------------------------------
TWO-YEAR CHRONIC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst AZT DATE: 06/03/96
EXPERIMENT: 89006 TEST: 06 TIME: 19:43:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-85225 ROUTE: GAVAGE NTP C#: C88072
PATHOLOGIST: R.B. THOMPSON CAS: 30516-87-1
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst AZT DATE: 06/03/96
EXPERIMENT: 89006 TEST: 06 TIME: 19:43:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-85225 ROUTE: GAVAGE NTP C#: C88072
PATHOLOGIST: R.B. THOMPSON CAS: 30516-87-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 1 AZT
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Carcinoma or Adenoma
Kidney: Renal Tubule Adenoma
Carcinoma or Adenoma
Liver Hepatoblastoma
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Thyroid Gland: Follicular Cell
Carcinoma or Adenoma
Vagina Squamous Cell Carcinoma
Squamous Cell Papilloma
All Organs Malignant Tumors
====================================================================================================
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 4/49 (8%) 1/49 (2%) 2/49 (4%) | 0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 14.9% 11.8% 3.4% 4.9% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/32 (13%) 4/34 (12%) 1/29 (3%) 2/41 (5%) | 0/34 (0%) 0/38 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 698 729 (T) 729 (T) 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073N P=0.464N P=0.131N P=0.136N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.082N P=0.477N P=0.123N P=0.176N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.083N P=0.479N P=0.126N P=0.161N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.118N | (e) |
|FISHER EXACT | P=0.513N P=0.107N P=0.226N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 2/50 (4%) 10/50 (20%) | 4/50 (8%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 9.4% 5.7% 6.3% 23.1% | 11.8% 5.1% 0.0% 3.2% |
|TERMINAL (d) | 3/32 (9%) 2/35 (6%) 1/29 (3%) 9/42 (21%) | 4/34 (12%) 2/39 (5%) 0/31 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 667 612 | 731 (T) 731 (T) --- 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016 * P=0.459N P=0.546N P=0.096 | P=0.107N P=0.275N P=0.074N P=0.207N |
|INCIDENTAL TUMOR | P=0.010 ** P=0.459N P=0.536N P=0.071 | P=0.107N P=0.275N P=0.074N P=0.207N |
|LOGISTIC REGRESSION | P=0.009 ** P=0.459N P=0.546N P=0.059 | P=0.107N P=0.275N P=0.074N P=0.207N |
|COCHRAN-ARMITAGE | P=0.004 ** | P=0.086N |
|FISHER EXACT | P=0.500N P=0.500N P=0.036 * | P=0.339N P=0.059N P=0.181N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 7.7% 0.0% 0.0% | 2.9% 0.0% 2.8% 3.2% |
|TERMINAL (d) | 0/32 (0%) 2/35 (6%) 0/29 (0%) 0/42 (0%) | 1/34 (3%) 0/39 (0%) 0/31 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- 458 --- --- | 731 (T) --- 689 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.278N P=0.132 (e) (e) | P=0.516 P=0.473N P=0.744 P=0.741 |
|INCIDENTAL TUMOR | P=0.262N P=0.134 (e) (e) | P=0.556 P=0.473N P=0.735 P=0.741 |
|LOGISTIC REGRESSION | P=0.321N P=0.126 (e) (e) | P=0.534 P=0.473N P=0.747 P=0.741 |
|COCHRAN-ARMITAGE | P=0.311N | P=0.539 |
|FISHER EXACT | P=0.121 (e) (e) | P=0.500N P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 2/50 (4%) 10/50 (20%) | 5/50 (10%) 2/50 (4%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 9.4% 13.3% 6.3% 23.1% | 14.7% 5.1% 2.8% 6.5% |
|TERMINAL (d) | 3/32 (9%) 4/35 (11%) 1/29 (3%) 9/42 (21%) | 5/34 (15%) 2/39 (5%) 0/31 (0%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 458 667 612 | 731 (T) 731 (T) 689 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.055 P=0.399 P=0.546N P=0.096 | P=0.200N P=0.163N P=0.125N P=0.253N |
|INCIDENTAL TUMOR | P=0.039 * P=0.400 P=0.536N P=0.071 | P=0.186N P=0.163N P=0.128N P=0.253N |
|LOGISTIC REGRESSION | P=0.027 * P=0.355 P=0.546N P=0.059 | P=0.173N P=0.163N P=0.121N P=0.253N |
|COCHRAN-ARMITAGE | P=0.019 * | P=0.162N |
|FISHER EXACT | P=0.357 P=0.500N P=0.036 * | P=0.218N P=0.102N P=0.218N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.1% 5.5% 3.4% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/32 (3%) 1/35 (3%) 1/29 (3%) 0/42 (0%) | 0/34 (0%) 0/39 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 722 729 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.204N P=0.534 P=0.740 P=0.446N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.242N P=0.503 P=0.740 P=0.446N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.213N P=0.524 P=0.740 P=0.446N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.247N | (e) |
|FISHER EXACT | P=0.500 P=0.753N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.1% 5.5% 3.4% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/32 (3%) 1/35 (3%) 1/29 (3%) 0/42 (0%) | 0/34 (0%) 0/39 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 722 729 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.204N P=0.534 P=0.740 P=0.446N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.242N P=0.503 P=0.740 P=0.446N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.213N P=0.524 P=0.740 P=0.446N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.247N | (e) |
|FISHER EXACT | P=0.500 P=0.753N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/49 (2%) 1/49 (2%) 0/50 (0%) | 0/49 (0%) 2/49 (4%) 1/50 (2%) 1/47 (2%) |
|ADJUSTED (b) | 0.0% 2.9% 3.4% 0.0% | 0.0% 5.1% 2.7% 3.0% |
|TERMINAL (d) | 0/32 (0%) 1/35 (3%) 1/29 (3%) 0/42 (0%) | 0/34 (0%) 2/39 (5%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) --- | --- 731 (T) 674 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.540N P=0.518 P=0.480 (e) | P=0.469 P=0.269 P=0.490 P=0.483 |
|INCIDENTAL TUMOR | P=0.540N P=0.518 P=0.480 (e) | P=0.525 P=0.269 P=0.473 P=0.523 |
|LOGISTIC REGRESSION | P=0.540N P=0.518 P=0.480 (e) | P=0.483 P=0.269 P=0.503 P=0.494 |
|COCHRAN-ARMITAGE | P=0.594N | P=0.488 |
|FISHER EXACT | P=0.495 P=0.495 (e) | P=0.247 P=0.505 P=0.490 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/48 (0%) 0/49 (0%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 7.1% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 0/29 (0%) 3/42 (7%) | 0/34 (0%) 0/39 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.022 * (e) (e) P=0.173 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.022 * (e) (e) P=0.173 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.022 * (e) (e) P=0.173 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.013 * | (e) |
|FISHER EXACT | (e) (e) P=0.121 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/48 (0%) 0/49 (0%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 9.5% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 0/29 (0%) 4/42 (10%) | 0/34 (0%) 0/39 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** (e) (e) P=0.103 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.007 ** (e) (e) P=0.103 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.007 ** (e) (e) P=0.103 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.003 ** | (e) |
|FISHER EXACT | (e) (e) P=0.059 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 6.3% 0.0% 3.4% 2.4% | 0.0% 0.0% 0.0% 3.0% |
|TERMINAL (d) | 2/32 (6%) 0/35 (0%) 1/29 (3%) 1/42 (2%) | 0/34 (0%) 0/39 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) 729 (T) | --- --- --- 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.427N P=0.219N P=0.535N P=0.405N | P=0.184 (e) (e) P=0.483 |
|INCIDENTAL TUMOR | P=0.427N P=0.219N P=0.535N P=0.405N | P=0.275 (e) (e) P=0.564 |
|LOGISTIC REGRESSION | P=0.427N P=0.219N P=0.535N P=0.405N | P=0.197 (e) (e) P=0.502 |
|COCHRAN-ARMITAGE | P=0.500N | P=0.198 |
|FISHER EXACT | P=0.247N P=0.500N P=0.500N | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 4/50 (8%) 4/50 (8%) 3/50 (6%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 13.5% 11.0% 12.8% 6.4% | 0.0% 5.1% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 3/35 (9%) 3/29 (10%) 1/42 (2%) | 0/34 (0%) 2/39 (5%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 570 711 639 513 | --- 731 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.160N P=0.350N P=0.440N P=0.209N | P=0.435N P=0.269 (e) (e) |
|INCIDENTAL TUMOR | P=0.345N P=0.599N P=0.501N P=0.668N | P=0.435N P=0.269 (e) (e) |
|LOGISTIC REGRESSION | P=0.301N P=0.359N P=0.435N P=0.536N | P=0.435N P=0.269 (e) (e) |
|COCHRAN-ARMITAGE | P=0.208N | P=0.405N |
|FISHER EXACT | P=0.370N P=0.370N P=0.243N | P=0.247 (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 6/50 (12%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 3.1% 5.7% 18.1% 4.8% | 2.9% 0.0% 0.0% 6.2% |
|TERMINAL (d) | 1/32 (3%) 2/35 (6%) 3/29 (10%) 2/42 (5%) | 1/34 (3%) 0/39 (0%) 0/31 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 638 729 (T) | 731 (T) --- --- 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.472 P=0.531 P=0.048 * P=0.595 | P=0.215 P=0.473N P=0.518N P=0.469 |
|INCIDENTAL TUMOR | P=0.358 P=0.531 P=0.046 * P=0.595 | P=0.265 P=0.473N P=0.518N P=0.515 |
|LOGISTIC REGRESSION | P=0.407 P=0.531 P=0.044 * P=0.595 | P=0.236 P=0.473N P=0.518N P=0.495 |
|COCHRAN-ARMITAGE | P=0.357 | P=0.246 |
|FISHER EXACT | P=0.500 P=0.056 P=0.500 | P=0.500N P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 23/50 (46%) 23/50 (46%) 26/50 (52%) | 20/50 (40%) 18/50 (36%) 17/50 (34%) 28/50 (56%) |
|ADJUSTED (b) | 65.2% 58.3% 66.8% 57.5% | 53.6% 44.9% 53.1% 67.5% |
|TERMINAL (d) | 19/32 (59%) 19/35 (54%) 18/29 (62%) 23/42 (55%) | 17/34 (50%) 17/39 (44%) 16/31 (52%) 18/31 (58%) |
|FIRST INCIDENCE (DAYS) | 576 458 473 540 | 607 648 722 467 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.239N P=0.292N P=0.550 P=0.215N | P=0.010 * P=0.234N P=0.475N P=0.058 |
|INCIDENTAL TUMOR | P=0.433N P=0.414N P=0.575 P=0.483N | P=0.022 * P=0.275N P=0.453N P=0.081 |
|LOGISTIC REGRESSION | P=0.537N P=0.422N P=0.574 P=0.528N | P=0.032 * P=0.317N P=0.457N P=0.082 |
|COCHRAN-ARMITAGE | P=0.415 | P=0.043 * |
|FISHER EXACT | P=0.421N P=0.421N P=0.500 | P=0.418N P=0.339N P=0.080 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 26/50 (52%) 22/50 (44%) 19/50 (38%) | 12/50 (24%) 17/50 (34%) 11/50 (22%) 15/50 (30%) |
|ADJUSTED (b) | 46.1% 61.6% 57.0% 40.4% | 30.3% 37.6% 30.7% 40.4% |
|TERMINAL (d) | 8/32 (25%) 19/35 (54%) 13/29 (45%) 14/42 (33%) | 8/34 (24%) 11/39 (28%) 7/31 (23%) 10/31 (32%) |
|FIRST INCIDENCE (DAYS) | 425 350 505 584 | 470 527 556 556 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.091N P=0.345 P=0.358 P=0.192N | P=0.309 P=0.314 P=0.588N P=0.273 |
|INCIDENTAL TUMOR | P=0.385N P=0.134 P=0.424 P=0.428 | P=0.394 P=0.112 P=0.501 P=0.243 |
|LOGISTIC REGRESSION | P=0.256N P=0.211 P=0.422 P=0.521N | P=0.411 P=0.159 P=0.544N P=0.325 |
|COCHRAN-ARMITAGE | P=0.250N | P=0.426 |
|FISHER EXACT | P=0.212 P=0.500 P=0.419N | P=0.189 P=0.500N P=0.326 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 27/50 (54%) 26/50 (52%) 19/50 (38%) | 13/50 (26%) 17/50 (34%) 11/50 (22%) 16/50 (32%) |
|ADJUSTED (b) | 46.1% 64.0% 64.6% 40.4% | 33.0% 37.6% 30.7% 43.2% |
|TERMINAL (d) | 8/32 (25%) 20/35 (57%) 15/29 (52%) 14/42 (33%) | 9/34 (26%) 11/39 (28%) 7/31 (23%) 11/31 (35%) |
|FIRST INCIDENCE (DAYS) | 425 350 505 584 | 470 527 556 556 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.091N P=0.289 P=0.153 P=0.192N | P=0.288 P=0.396 P=0.503N P=0.271 |
|INCIDENTAL TUMOR | P=0.409N P=0.097 P=0.134 P=0.428 | P=0.368 P=0.168 P=0.590 P=0.241 |
|LOGISTIC REGRESSION | P=0.260N P=0.157 P=0.140 P=0.521N | P=0.390 P=0.225 P=0.455N P=0.329 |
|COCHRAN-ARMITAGE | P=0.259N | P=0.406 |
|FISHER EXACT | P=0.158 P=0.212 P=0.419N | P=0.257 P=0.408N P=0.330 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 36/50 (72%) 39/50 (78%) 34/50 (68%) 39/50 (78%) | 27/50 (54%) 29/50 (58%) 23/50 (46%) 36/50 (72%) |
|ADJUSTED (b) | 76.5% 88.5% 84.7% 79.6% | 65.2% 63.0% 63.6% 85.3% |
|TERMINAL (d) | 21/32 (66%) 30/35 (86%) 23/29 (79%) 32/42 (76%) | 20/34 (59%) 22/39 (56%) 18/31 (58%) 25/31 (81%) |
|FIRST INCIDENCE (DAYS) | 425 350 473 540 | 470 527 556 467 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.160N P=0.543 P=0.469 P=0.236N | P=0.018 * P=0.478N P=0.443N P=0.038 * |
|INCIDENTAL TUMOR | P=0.452 P=0.257 P=0.580N P=0.241 | P=0.028 * P=0.389 P=0.501N P=0.027 * |
|LOGISTIC REGRESSION | P=0.487 P=0.301 P=0.580N P=0.341 | P=0.040 * P=0.463 P=0.394N P=0.046 * |
|COCHRAN-ARMITAGE | P=0.372 | P=0.053 |
|FISHER EXACT | P=0.322 P=0.414N P=0.322 | P=0.420 P=0.274N P=0.048 * |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 36/50 (72%) 39/50 (78%) 36/50 (72%) 39/50 (78%) | 27/50 (54%) 29/50 (58%) 23/50 (46%) 36/50 (72%) |
|ADJUSTED (b) | 76.5% 88.5% 87.6% 79.6% | 65.2% 63.0% 63.6% 85.3% |
|TERMINAL (d) | 21/32 (66%) 30/35 (86%) 24/29 (83%) 32/42 (76%) | 20/34 (59%) 22/39 (56%) 18/31 (58%) 25/31 (81%) |
|FIRST INCIDENCE (DAYS) | 425 350 473 540 | 470 527 556 467 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.165N P=0.543 P=0.341 P=0.236N | P=0.018 * P=0.478N P=0.443N P=0.038 * |
|INCIDENTAL TUMOR | P=0.418 P=0.257 P=0.413 P=0.241 | P=0.028 * P=0.389 P=0.501N P=0.027 * |
|LOGISTIC REGRESSION | P=0.468 P=0.301 P=0.404 P=0.341 | P=0.040 * P=0.463 P=0.394N P=0.046 * |
|COCHRAN-ARMITAGE | P=0.350 | P=0.053 |
|FISHER EXACT | P=0.322 P=0.588N P=0.322 | P=0.420 P=0.274N P=0.048 * |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 7/50 (14%) 11/50 (22%) 8/50 (16%) | 3/49 (6%) 3/50 (6%) 2/50 (4%) 7/50 (14%) |
|ADJUSTED (b) | 33.2% 19.1% 32.8% 18.6% | 7.6% 7.7% 5.3% 21.5% |
|TERMINAL (d) | 9/32 (28%) 6/35 (17%) 7/29 (24%) 7/42 (17%) | 1/34 (3%) 3/39 (8%) 1/31 (3%) 6/31 (19%) |
|FIRST INCIDENCE (DAYS) | 565 624 584 694 | 647 731 (T) 288 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.146N P=0.118N P=0.572 P=0.093N | P=0.057 P=0.611N P=0.538N P=0.140 |
|INCIDENTAL TUMOR | P=0.267N P=0.176N P=0.574 P=0.189N | P=0.091 P=0.635 P=0.346N P=0.170 |
|LOGISTIC REGRESSION | P=0.228N P=0.150N P=0.592N P=0.172N | P=0.082 P=0.649N P=0.415N P=0.164 |
|COCHRAN-ARMITAGE | P=0.292N | P=0.083 |
|FISHER EXACT | P=0.154N P=0.500N P=0.227N | P=0.651N P=0.490N P=0.167 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 3/50 (6%) 4/50 (8%) | 3/49 (6%) 5/50 (10%) 0/50 (0%) 4/50 (8%) |
|ADJUSTED (b) | 11.2% 5.7% 10.3% 9.3% | 8.8% 11.6% 0.0% 10.4% |
|TERMINAL (d) | 2/32 (6%) 2/35 (6%) 3/29 (10%) 3/42 (7%) | 3/34 (9%) 3/39 (8%) 0/31 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 596 729 (T) 729 (T) 695 | 731 (T) 589 --- 625 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.545N P=0.304N P=0.550N P=0.514N | P=0.532 P=0.426 P=0.137N P=0.480 |
|INCIDENTAL TUMOR | P=0.502 P=0.374N P=0.560N P=0.564 | P=0.522N P=0.455 P=0.137N P=0.559 |
|LOGISTIC REGRESSION | P=0.536 P=0.335N P=0.550N P=0.616N | P=0.578N P=0.365 P=0.137N P=0.509 |
|COCHRAN-ARMITAGE | P=0.481 | P=0.572N |
|FISHER EXACT | P=0.339N P=0.500N P=0.643N | P=0.369 P=0.117N P=0.511 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 9/50 (18%) 14/50 (28%) 11/50 (22%) | 6/49 (12%) 8/50 (16%) 2/50 (4%) 11/50 (22%) |
|ADJUSTED (b) | 38.0% 24.7% 41.9% 25.0% | 16.0% 18.9% 5.3% 30.3% |
|TERMINAL (d) | 10/32 (31%) 8/35 (23%) 10/29 (34%) 9/42 (21%) | 4/34 (12%) 6/39 (15%) 1/31 (3%) 7/31 (23%) |
|FIRST INCIDENCE (DAYS) | 565 624 584 694 | 647 589 288 625 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.201N P=0.127N P=0.462 P=0.134N | P=0.101 P=0.479 P=0.169N P=0.128 |
|INCIDENTAL TUMOR | P=0.366N P=0.190N P=0.463 P=0.312N | P=0.180 P=0.444 P=0.077N P=0.177 |
|LOGISTIC REGRESSION | P=0.312N P=0.163N P=0.476 P=0.238N | P=0.142 P=0.405 P=0.112N P=0.151 |
|COCHRAN-ARMITAGE | P=0.411N | P=0.146 |
|FISHER EXACT | P=0.171N P=0.588N P=0.322N | P=0.403 P=0.128N P=0.154 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Mesentery |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.4% 0.0% | 4.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 1/29 (3%) 0/42 (0%) | 0/34 (0%) 0/39 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) --- | 610 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.718 (e) P=0.480 (e) | P=0.119N P=0.227N P=0.256N P=0.237N |
|INCIDENTAL TUMOR | P=0.718 (e) P=0.480 (e) | P=0.082N P=0.256N P=0.197N P=0.154N |
|LOGISTIC REGRESSION | P=0.718 (e) P=0.480 (e) | P=0.102N P=0.300N P=0.209N P=0.220N |
|COCHRAN-ARMITAGE | P=0.694 | P=0.115N |
|FISHER EXACT | (e) P=0.500 (e) | P=0.247N P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 2/50 (4%) 3/47 (6%) 0/48 (0%) |
|ADJUSTED (b) | | 5.9% 4.7% 10.0% 0.0% |
|TERMINAL (d) | | 2/34 (6%) 1/39 (3%) 2/28 (7%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | | 731 (T) 617 713 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.251N P=0.648N P=0.422 P=0.274N |
|INCIDENTAL TUMOR | | P=0.207N P=0.630N P=0.418 P=0.274N |
|LOGISTIC REGRESSION | | P=0.221N P=0.691N P=0.417 P=0.274N |
|COCHRAN-ARMITAGE | | P=0.213N |
|FISHER EXACT | | P=0.691N P=0.470 P=0.258N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 0/47 (0%) 0/48 (0%) |
|ADJUSTED (b) | | 0.0% 5.0% 0.0% 0.0% |
|TERMINAL (d) | | 0/34 (0%) 1/39 (3%) 0/28 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 690 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.426N P=0.261 (e) (e) |
|INCIDENTAL TUMOR | | P=0.381N P=0.202 (e) (e) |
|LOGISTIC REGRESSION | | P=0.420N P=0.246 (e) (e) |
|COCHRAN-ARMITAGE | | P=0.415N |
|FISHER EXACT | | P=0.247 (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/40 (0%) 0/46 (0%) 0/42 (0%) 0/47 (0%) | 2/46 (4%) 5/49 (10%) 1/46 (2%) 0/46 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 6.3% 12.1% 3.4% 0.0% |
|TERMINAL (d) | 0/25 (0%) 0/34 (0%) 0/26 (0%) 0/39 (0%) | 2/32 (6%) 4/39 (10%) 1/29 (3%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 731 (T) 589 731 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.093N P=0.295 P=0.535N P=0.260N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.074N P=0.317 P=0.535N P=0.260N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.077N P=0.257 P=0.535N P=0.260N |
|COCHRAN-ARMITAGE | (e) | P=0.073N |
|FISHER EXACT | (e) (e) (e) | P=0.245 P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 5.0% 2.2% 8.3% 2.4% | 0.0% 2.6% 6.5% 5.1% |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 1/29 (3%) 1/42 (2%) | 0/34 (0%) 1/39 (3%) 2/31 (6%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 325 568 422 729 (T) | --- 731 (T) 731 (T) 695 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.425N P=0.492N P=0.465 P=0.441N | P=0.144 P=0.527 P=0.218 P=0.251 |
|INCIDENTAL TUMOR | P=0.614N P=0.478N P=0.662 P=0.707 | P=0.191 P=0.527 P=0.218 P=0.307 |
|LOGISTIC REGRESSION | P=0.524N P=0.421N P=0.616 P=0.695N | P=0.157 P=0.527 P=0.218 P=0.238 |
|COCHRAN-ARMITAGE | P=0.474N | P=0.160 |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | P=0.500 P=0.247 P=0.247 |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 2.0% 0.0% 5.5% 2.4% | 0.0% 2.6% 6.5% 5.1% |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 1/29 (3%) 1/42 (2%) | 0/34 (0%) 1/39 (3%) 2/31 (6%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 325 --- 422 729 (T) | --- 731 (T) 731 (T) 695 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.539 P=0.504N P=0.474 P=0.731N | P=0.144 P=0.527 P=0.218 P=0.251 |
|INCIDENTAL TUMOR | P=0.483 P=0.282N P=0.709 P=0.554 | P=0.191 P=0.527 P=0.218 P=0.307 |
|LOGISTIC REGRESSION | P=0.449 P=0.267N P=0.680 P=0.553 | P=0.157 P=0.527 P=0.218 P=0.238 |
|COCHRAN-ARMITAGE | P=0.500 | P=0.160 |
|FISHER EXACT | P=0.500N P=0.500 P=0.753N | P=0.500 P=0.247 P=0.247 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 5.0% 2.2% 8.3% 2.4% | 0.0% 2.6% 6.5% 5.1% |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 1/29 (3%) 1/42 (2%) | 0/34 (0%) 1/39 (3%) 2/31 (6%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 325 568 422 729 (T) | --- 731 (T) 731 (T) 695 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.425N P=0.492N P=0.465 P=0.441N | P=0.144 P=0.527 P=0.218 P=0.251 |
|INCIDENTAL TUMOR | P=0.614N P=0.478N P=0.662 P=0.707 | P=0.191 P=0.527 P=0.218 P=0.307 |
|LOGISTIC REGRESSION | P=0.524N P=0.421N P=0.616 P=0.695N | P=0.157 P=0.527 P=0.218 P=0.238 |
|COCHRAN-ARMITAGE | P=0.474N | P=0.160 |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | P=0.500 P=0.247 P=0.247 |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/49 (2%) 0/48 (0%) 0/50 (0%) | 1/49 (2%) 0/48 (0%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 5.7% 2.9% 0.0% 0.0% | 2.2% 0.0% 2.4% 0.0% |
|TERMINAL (d) | 1/32 (3%) 1/35 (3%) 0/28 (0%) 0/42 (0%) | 0/34 (0%) 0/39 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 698 729 (T) --- --- | 523 --- 612 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.089N P=0.476N P=0.274N P=0.197N | P=0.406N P=0.483N P=0.753 P=0.496N |
|INCIDENTAL TUMOR | P=0.105N P=0.497N P=0.254N P=0.293N | P=0.413N P=0.638N P=0.751 P=0.638N |
|LOGISTIC REGRESSION | P=0.095N P=0.494N P=0.266N P=0.217N | P=0.350N P=0.728N P=0.709N P=0.428N |
|COCHRAN-ARMITAGE | P=0.102N | P=0.400N |
|FISHER EXACT | P=0.508N P=0.258N P=0.247N | P=0.505N P=0.753N P=0.495N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 3/50 (6%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 8.8% 7.7% 3.2% 5.4% |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 0/29 (0%) 0/42 (0%) | 3/34 (9%) 3/39 (8%) 1/31 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 731 (T) 731 (T) 731 (T) 612 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.399N P=0.599N P=0.338N P=0.529N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.377N P=0.599N P=0.338N P=0.488N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.351N P=0.599N P=0.338N P=0.498N |
|COCHRAN-ARMITAGE | (e) | P=0.343N |
|FISHER EXACT | (e) (e) (e) | P=0.661N P=0.309N P=0.500N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 3/50 (6%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 8.8% 7.7% 3.2% 3.2% |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 0/29 (0%) 0/42 (0%) | 3/34 (9%) 3/39 (8%) 1/31 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 731 (T) 731 (T) 731 (T) 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.202N P=0.599N P=0.338N P=0.338N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.202N P=0.599N P=0.338N P=0.338N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.202N P=0.599N P=0.338N P=0.338N |
|COCHRAN-ARMITAGE | (e) | P=0.165N |
|FISHER EXACT | (e) (e) (e) | P=0.661N P=0.309N P=0.309N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/49 (8%) 2/48 (4%) 1/50 (2%) | 3/49 (6%) 2/50 (4%) 4/50 (8%) 0/50 (0%) |
|ADJUSTED (b) | 5.5% 11.4% 6.5% 2.4% | 8.1% 5.1% 12.9% 0.0% |
|TERMINAL (d) | 1/32 (3%) 4/35 (11%) 1/29 (3%) 1/42 (2%) | 2/34 (6%) 2/39 (5%) 4/31 (13%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 638 729 (T) 691 729 (T) | 647 731 (T) 731 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.196N P=0.374 P=0.657 P=0.424N | P=0.170N P=0.446N P=0.449 P=0.134N |
|INCIDENTAL TUMOR | P=0.256N P=0.300 P=0.614 P=0.544N | P=0.155N P=0.492N P=0.446 P=0.114N |
|LOGISTIC REGRESSION | P=0.233N P=0.337 P=0.661 P=0.496N | P=0.142N P=0.475N P=0.460 P=0.118N |
|COCHRAN-ARMITAGE | P=0.263N | P=0.132N |
|FISHER EXACT | P=0.329 P=0.676 P=0.500N | P=0.490N P=0.511 P=0.117N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/49 (8%) 2/48 (4%) 1/50 (2%) | 4/49 (8%) 3/50 (6%) 4/50 (8%) 0/50 (0%) |
|ADJUSTED (b) | 5.5% 11.4% 6.5% 2.4% | 10.7% 7.7% 12.9% 0.0% |
|TERMINAL (d) | 1/32 (3%) 4/35 (11%) 1/29 (3%) 1/42 (2%) | 2/34 (6%) 3/39 (8%) 4/31 (13%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 638 729 (T) 691 729 (T) | 647 731 (T) 731 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.196N P=0.374 P=0.657 P=0.424N | P=0.088N P=0.438N P=0.586 P=0.077N |
|INCIDENTAL TUMOR | P=0.256N P=0.300 P=0.614 P=0.544N | P=0.070N P=0.519N P=0.586 P=0.049N* |
|LOGISTIC REGRESSION | P=0.233N P=0.337 P=0.661 P=0.496N | P=0.068N P=0.467N P=0.603 P=0.061N |
|COCHRAN-ARMITAGE | P=0.263N | P=0.061N |
|FISHER EXACT | P=0.329 P=0.676 P=0.500N | P=0.489N P=0.631N P=0.056N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 2.6% 5.1% 0.0% 0.0% |
|TERMINAL (d) | | 0/34 (0%) 2/39 (5%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | | 691 731 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.204N P=0.535 P=0.522N P=0.490N |
|INCIDENTAL TUMOR | | P=0.182N P=0.478 P=0.527N P=0.436N |
|LOGISTIC REGRESSION | | P=0.192N P=0.519 P=0.509N P=0.500N |
|COCHRAN-ARMITAGE | | P=0.188N |
|FISHER EXACT | | P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | | 2.6% 5.1% 0.0% 3.2% |
|TERMINAL (d) | | 0/34 (0%) 2/39 (5%) 0/31 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | | 691 731 (T) --- 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.532N P=0.535 P=0.522N P=0.756 |
|INCIDENTAL TUMOR | | P=0.496N P=0.478 P=0.527N P=0.736N |
|LOGISTIC REGRESSION | | P=0.507N P=0.519 P=0.509N P=0.761N |
|COCHRAN-ARMITAGE | | P=0.500N |
|FISHER EXACT | | P=0.500 P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Vagina |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 5/50 (10%) 9/50 (18%) |
|ADJUSTED (b) | | 0.0% 0.0% 12.7% 26.8% |
|TERMINAL (d) | | 0/34 (0%) 0/39 (0%) 1/31 (3%) 7/31 (23%) |
|FIRST INCIDENCE (DAYS) | | --- --- 493 695 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P<0.001 ** (e) P=0.031 * P=0.002 ** |
|INCIDENTAL TUMOR | | P<0.001 ** (e) P=0.027 * P=0.003 ** |
|LOGISTIC REGRESSION | | P<0.001 ** (e) P=0.037 * P=0.002 ** |
|COCHRAN-ARMITAGE | | P<0.001 ** |
|FISHER EXACT | | (e) P=0.028 * P=0.001 ** |
|=================================================================================================================================|
| |
|Vagina |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 0.0% 0.0% 6.5% |
|TERMINAL (d) | | 0/34 (0%) 0/39 (0%) 0/31 (0%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | | --- --- --- 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.036 * (e) (e) P=0.218 |
|INCIDENTAL TUMOR | | P=0.036 * (e) (e) P=0.218 |
|LOGISTIC REGRESSION | | P=0.036 * (e) (e) P=0.218 |
|COCHRAN-ARMITAGE | | P=0.046 * |
|FISHER EXACT | | (e) (e) P=0.247 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 6.3% 2.9% 6.9% 2.4% | 0.0% 0.0% 2.3% 5.3% |
|TERMINAL (d) | 2/32 (6%) 1/35 (3%) 2/29 (7%) 1/42 (2%) | 0/34 (0%) 0/39 (0%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 729 (T) | --- --- 556 666 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.358N P=0.469N P=0.660 P=0.405N | P=0.070 (e) P=0.491 P=0.238 |
|INCIDENTAL TUMOR | P=0.358N P=0.469N P=0.660 P=0.405N | P=0.136 (e) P=0.602 P=0.307 |
|LOGISTIC REGRESSION | P=0.358N P=0.469N P=0.660 P=0.405N | P=0.072 (e) P=0.565 P=0.237 |
|COCHRAN-ARMITAGE | P=0.444N | P=0.070 |
|FISHER EXACT | P=0.500N P=0.691N P=0.500N | (e) P=0.500 P=0.247 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 6/50 (12%) 4/50 (8%) 3/50 (6%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 16.2% 16.1% 12.8% 6.4% | 2.2% 5.1% 2.4% 4.7% |
|TERMINAL (d) | 1/32 (3%) 4/35 (11%) 3/29 (10%) 1/42 (2%) | 0/34 (0%) 2/39 (5%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 570 711 639 513 | 523 731 (T) 612 601 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.072N P=0.460N P=0.332N P=0.129N | P=0.426 P=0.541 P=0.753 P=0.508 |
|INCIDENTAL TUMOR | P=0.184N P=0.541 P=0.372N P=0.477N | P=0.460 P=0.431 P=0.732 P=0.495 |
|LOGISTIC REGRESSION | P=0.146N P=0.497N P=0.250N P=0.357N | P=0.459 P=0.445 P=0.714N P=0.533 |
|COCHRAN-ARMITAGE | P=0.101N | P=0.444 |
|FISHER EXACT | P=0.500N P=0.262N P=0.159N | P=0.500 P=0.753N P=0.500 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 6/50 (12%) 6/50 (12%) 4/50 (8%) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 4/50 (8%) |
|ADJUSTED (b) | 21.6% 16.1% 19.5% 8.7% | 2.2% 5.1% 4.7% 9.8% |
|TERMINAL (d) | 3/32 (9%) 4/35 (11%) 5/29 (17%) 2/42 (5%) | 0/34 (0%) 2/39 (5%) 0/31 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 570 711 639 513 | 523 731 (T) 556 601 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.064N P=0.259N P=0.372N P=0.081N | P=0.109 P=0.541 P=0.487 P=0.189 |
|INCIDENTAL TUMOR | P=0.156N P=0.452N P=0.413N P=0.301N | P=0.164 P=0.431 P=0.518 P=0.207 |
|LOGISTIC REGRESSION | P=0.101N P=0.288N P=0.307N P=0.239N | P=0.119 P=0.445 P=0.603 P=0.189 |
|COCHRAN-ARMITAGE | P=0.103N | P=0.113 |
|FISHER EXACT | P=0.288N P=0.288N P=0.117N | P=0.500 P=0.500 P=0.181 |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.3% 0.0% 0.0% | 4.0% 2.0% 8.3% 2.7% |
|TERMINAL (d) | 0/32 (0%) 1/35 (3%) 0/29 (0%) 0/42 (0%) | 0/34 (0%) 0/39 (0%) 1/31 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- 665 --- --- | 379 527 582 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.369N P=0.255 (e) (e) | P=0.486N P=0.488N P=0.461 P=0.499N |
|INCIDENTAL TUMOR | P=0.444N P=0.232 (e) (e) | P=0.547N P=0.712 P=0.364 P=0.676N |
|LOGISTIC REGRESSION | P=0.398N P=0.237 (e) (e) | P=0.404N P=0.319 P=0.637 P=0.396N |
|COCHRAN-ARMITAGE | P=0.405N | P=0.474N |
|FISHER EXACT | P=0.247 (e) (e) | P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 6/50 (12%) 7/50 (14%) 5/50 (10%) | 5/50 (10%) 10/50 (20%) 7/50 (14%) 9/50 (18%) |
|ADJUSTED (b) | 2.5% 13.3% 22.0% 11.5% | 12.6% 24.0% 18.4% 25.3% |
|TERMINAL (d) | 0/32 (0%) 1/35 (3%) 5/29 (17%) 4/42 (10%) | 2/34 (6%) 8/39 (21%) 3/31 (10%) 6/31 (19%) |
|FIRST INCIDENCE (DAYS) | 638 257 596 612 | 603 636 219 625 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277 P=0.070 P=0.027 * P=0.164 | P=0.203 P=0.195 P=0.328 P=0.180 |
|INCIDENTAL TUMOR | P=0.097 P=0.059 P=0.021 * P=0.070 | P=0.372 P=0.148 P=0.600 P=0.259 |
|LOGISTIC REGRESSION | P=0.141 P=0.073 P=0.025 * P=0.097 | P=0.268 P=0.139 P=0.450 P=0.194 |
|COCHRAN-ARMITAGE | P=0.174 | P=0.265 |
|FISHER EXACT | P=0.056 P=0.030 * P=0.102 | P=0.131 P=0.380 P=0.194 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 33/50 (66%) 31/50 (62%) 29/50 (58%) 42/50 (84%) | 30/50 (60%) 33/50 (66%) 26/50 (52%) 31/50 (62%) |
|ADJUSTED (b) | 78.2% 77.1% 78.0% 89.3% | 76.7% 76.6% 69.8% 73.3% |
|TERMINAL (d) | 23/32 (72%) 26/35 (74%) 21/29 (72%) 37/42 (88%) | 25/34 (74%) 29/39 (74%) 20/31 (65%) 20/31 (65%) |
|FIRST INCIDENCE (DAYS) | 565 458 473 540 | 607 589 288 467 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.392 P=0.264N P=0.507N P=0.566 | P=0.288 P=0.504N P=0.462N P=0.362 |
|INCIDENTAL TUMOR | P=0.064 P=0.487N P=0.489N P=0.068 | P=0.534 P=0.567 P=0.311N P=0.512 |
|LOGISTIC REGRESSION | P=0.048 * P=0.431N P=0.464N P=0.075 | P=0.535N P=0.490 P=0.414N P=0.534 |
|COCHRAN-ARMITAGE | P=0.022 * | P=0.500N |
|FISHER EXACT | P=0.418N P=0.268N P=0.032 * | P=0.339 P=0.273N P=0.500 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30 MG/KG 60 MG/KG 120 | VEHICLE 30 MG/KG 60 MG/KG 120 |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 28/50 (56%) 40/50 (80%) 39/50 (78%) 29/50 (58%) | 26/50 (52%) 30/50 (60%) 28/50 (56%) 35/50 (70%) |
|ADJUSTED (b) | 58.0% 80.0% 84.8% 60.4% | 55.8% 62.5% 60.8% 77.4% |
|TERMINAL (d) | 12/32 (38%) 25/35 (71%) 22/29 (76%) 23/42 (55%) | 14/34 (41%) 21/39 (54%) 13/31 (42%) 21/31 (68%) |
|FIRST INCIDENCE (DAYS) | 325 257 422 513 | 379 527 219 556 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.109N P=0.098 P=0.028 * P=0.270N | P=0.044 * P=0.500 P=0.309 P=0.071 |
|INCIDENTAL TUMOR | P=0.480 P=0.003 ** P=0.008 ** P=0.197 | P=0.080 P=0.161 P=0.339 P=0.050 * |
|LOGISTIC REGRESSION | P=0.512N P=0.004 ** P=0.006 ** P=0.335 | P=0.031 * P=0.190 P=0.335 P=0.051 |
|COCHRAN-ARMITAGE | P=0.379N | P=0.051 |
|FISHER EXACT | P=0.009 ** P=0.016 * P=0.500 | P=0.273 P=0.421 P=0.050 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 43/50 (86%) 49/50 (98%) 45/50 (90%) 50/50 (100%)| 41/50 (82%) 42/50 (84%) 41/50 (82%) 43/50 (86%) |
|ADJUSTED (b) | 86.0% 98.0% 97.8% 100.0% | 85.3% 87.5% 87.2% 91.4% |
|TERMINAL (d) | 25/32 (78%) 34/35 (97%) 28/29 (97%) 42/42 (100%)| 27/34 (79%) 33/39 (85%) 25/31 (81%) 27/31 (87%) |
|FIRST INCIDENCE (DAYS) | 325 257 422 513 | 379 527 219 467 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.244N P=0.379 P=0.206 P=0.341N | P=0.161 P=0.318N P=0.345 P=0.293 |
|INCIDENTAL TUMOR | P=0.013 * P=0.022 * P=0.194 P=0.003 ** | P=0.382 P=0.485 P=0.518 P=0.333 |
|LOGISTIC REGRESSION | P=0.010 * P=0.022 * P=0.151 P=0.003 ** | P=0.317 P=0.480 P=0.535 P=0.382 |
|COCHRAN-ARMITAGE | P=0.019 * | P=0.362 |
|FISHER EXACT | P=0.030 * P=0.380 P=0.006 ** | P=0.500 P=0.602N P=0.393 |
|=================================================================================================================================|
DATE: 06/04/96 EXPERIMENT: 89006 TEST: 06 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 AZT
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).