TDMS Study 89006-08 Pathology Tables
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
Facility: Southern Research Institute
Chemical CAS #: 76543-88-9
Lock Date: 09/03/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 13 13 9 11
Natural Death 12 5 15 8
Dosing Accident 1
Survivors
Terminal Sacrifice 25 32 25 31
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (47) (50) (50) (49)
Artery, Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (47) (50) (49) (48)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (49) (50) (50) (50)
Angiectasis 1 (2%) 2 (4%) 3 (6%)
Basophilic Focus 3 (6%) 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%)
Eosinophilic Focus 1 (2%) 8 (16%) 8 (16%) 8 (16%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 3 (6%) 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Inflammation, Chronic 4 (8%) 6 (12%) 10 (20%) 9 (18%)
Mixed Cell Focus 4 (8%) 4 (8%) 1 (2%)
Necrosis, Focal 3 (6%) 5 (10%) 5 (10%) 3 (6%)
Pigmentation, Focal 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 5 (10%) 2 (4%) 3 (6%) 3 (6%)
Artery, Inflammation, Chronic 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%)
Hepatocyte, Karyomegaly 2 (4%) 1 (2%) 1 (2%)
Mesentery (21) (21) (18) (16)
Accessory Spleen 1 (5%)
Angiectasis 1 (5%)
Fibrosis, Focal 1 (6%)
Infiltration Cellular, Mixed Cell 1 (6%)
Inflammation, Chronic 1 (5%) 3 (17%)
Artery, Inflammation, Chronic 1 (5%) 2 (13%)
Fat, Necrosis 13 (62%) 12 (57%) 12 (67%) 10 (63%)
Pancreas (48) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Necrosis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy, Diffuse 2 (4%)
Acinus, Atrophy, Focal 1 (2%) 1 (2%)
Duct, Cyst 3 (6%)
Salivary Glands (50) (50) (48) (49)
Inflammation, Chronic 1 (2%)
Stomach, Forestomach (48) (50) (50) (46)
Diverticulum 2 (4%)
Edema 1 (2%)
Erosion 5 (10%) 3 (6%) 1 (2%)
Inflammation, Chronic 3 (6%) 3 (6%) 3 (7%)
Epithelium, Cyst 1 (2%)
Epithelium, Hyperplasia 7 (15%) 4 (8%) 4 (9%)
Stomach, Glandular (48) (50) (50) (46)
Erosion 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Pigmentation, Focal 1 (2%) 2 (4%) 2 (4%)
Artery, Inflammation, Chronic 1 (2%)
Glands, Degeneration, Cystic, Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (49)
Inflammation, Chronic 1 (2%)
Pulmonary Vein, Intima, Mineralization, Focal 1 (2%)
Heart (50) (50) (50) (50)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (49)
Accessory Adrenal Cortical Nodule 3 (6%) 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Hyperplasia 1 (2%)
Hypertrophy, Focal 1 (2%)
Capsule, Hyperplasia, Focal 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Adrenal Medulla (50) (49) (50) (49)
Hyperplasia 2 (4%)
Islets, Pancreatic (48) (50) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (44) (46) (46) (47)
Cyst 1 (2%) 1 (2%)
Pituitary Gland (46) (47) (44) (43)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Angiectasis 1 (2%) 3 (6%) 1 (2%) 3 (7%)
Pars Distalis, Cytoplasmic Alteration, Focal 1 (2%) 3 (6%) 4 (9%) 2 (5%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (49) (50)
Angiectasis 1 (2%)
Degeneration, Cystic, Focal 8 (16%) 9 (18%) 10 (20%) 8 (16%)
Inflammation, Chronic, Focal 2 (4%) 1 (2%) 1 (2%)
C-Cell, Hyperplasia 1 (2%) 1 (2%)
Follicle, Cyst 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 17 (34%) 21 (42%) 18 (37%) 14 (28%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1)
Infiltration Cellular, Histiocyte 1 (50%)
Infiltration Cellular, Mixed Cell 1 (100%)
Tissue NOS (1) (1) (2)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (49) (47) (49)
Degeneration, Cystic 3 (6%) 3 (6%) 2 (4%) 6 (12%)
Ovary (46) (48) (49) (48)
Angiectasis 2 (4%) 3 (6%)
Atrophy 1 (2%)
Cyst 10 (22%) 11 (23%) 7 (14%) 8 (17%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Bilateral, Cyst 1 (2%) 2 (4%) 1 (2%)
Oviduct (1)
Inflammation, Suppurative 1 (100%)
Uterus (50) (50) (50) (50)
Angiectasis 1 (2%)
Hydrometra 10 (20%) 11 (22%) 11 (22%) 20 (40%)
Inflammation, Suppurative 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 48 (96%) 49 (98%) 46 (92%) 48 (96%)
Vagina (48) (50) (47) (46)
Inflammation, Chronic 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Depletion Cellular 1 (2%)
Hyperplasia 2 (4%) 2 (4%)
Lymph Node (12) (13) (9) (11)
Iliac, Hemorrhage 1 (8%)
Iliac, Hyperplasia 1 (9%)
Iliac, Hyperplasia, Lymphoid 1 (8%)
Inguinal, Hyperplasia 2 (17%)
Inguinal, Hyperplasia, Lymphoid 1 (11%) 1 (9%)
Mediastinal, Hyperplasia 1 (8%) 2 (22%) 1 (9%)
Mediastinal, Hyperplasia, Lymphoid 1 (8%) 2 (15%) 1 (11%)
Mediastinal, Inflammation, Focal, Suppurative 1 (11%) 1 (9%)
Pancreatic, Hyperplasia, Lymphoid 1 (8%)
Renal, Hemorrhage 1 (8%)
Renal, Hyperplasia, Lymphoid 1 (8%) 1 (9%)
Lymph Node, Mandibular (49) (49) (47) (48)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Lymph Node, Mesenteric (45) (50) (50) (47)
Angiectasis 1 (2%) 1 (2%)
Ectasia 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 2 (4%) 2 (4%) 1 (2%)
Hyperplasia 2 (4%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 3 (7%) 4 (8%) 3 (6%) 2 (4%)
Inflammation, Focal, Suppurative 1 (2%)
Pigmentation 1 (2%)
Spleen (47) (50) (50) (49)
Hematopoietic Cell Proliferation 21 (45%) 24 (48%) 26 (52%) 20 (41%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 3 (6%) 4 (8%) 2 (4%) 5 (10%)
Necrosis, Focal 1 (2%)
Thymus (41) (48) (48) (39)
Cyst 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Histiocytic 1 (3%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (50) (50)
Ectasia 1 (2%) 1 (2%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Ulcer 1 (2%)
Artery, Subcutaneous Tissue, Inflammation,
Chronic 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 2 (4%)
Subcutaneous Tissue, Hemorrhage, Focal 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%)
Osteoporosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Atrophy, Focal 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%)
Spinal Cord (2) (2) (4) (1)
Hemorrhage, Focal 1 (25%)
Meninges, Inflammation, Focal 1 (25%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Hyperplasia, Histiocytic 4 (8%) 2 (4%) 1 (2%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Pigmentation, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Bronchus, Glands, Cyst 1 (2%)
Mediastinum, Infiltration Cellular, Mixed
Cell 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%) 1 (2%)
Mediastinum, Necrosis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Mucosa, Glands, Dilatation, Focal 41 (82%) 42 (84%) 41 (82%) 40 (80%)
Nasolacrimal Duct, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1)
Atrophy 1 (33%)
Inflammation, Chronic 1 (33%)
Anterior Chamber, Infiltration Cellular,
Polymorphonuclear 1 (33%)
Cornea, Inflammation, Chronic 2 (67%) 1 (100%)
Cornea, Necrosis, Focal 1 (33%)
Harderian Gland (3) (8) (4) (3)
Hyperplasia, Focal 1 (13%) 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (48) (50) (49) (50)
Cyst 1 (2%) 1 (2%)
Metaplasia, Focal, Osseous 3 (6%) 1 (2%) 2 (4%)
Nephropathy 29 (60%) 38 (76%) 31 (63%) 31 (62%)
Artery, Inflammation, Chronic 1 (2%)
Pelvis, Dilatation 2 (4%) 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 3 (6%) 1 (2%) 2 (4%)
Renal Tubule, Dilatation 2 (4%) 3 (6%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 2 (4%) 2 (4%)
Urethra (1) (1)
Inflammation, Chronic 1 (100%)
Artery, Inflammation, Chronic 1 (100%)
Urinary Bladder (50) (50) (50) (50)
Artery, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 10 15 11 13
Moribund Sacrifice 13 7 10 10
Dosing Accident 1
Survivors
Terminal Sacrifice 27 28 28 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (45) (48) (43)
Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (49) (49) (49) (50)
Congestion 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 2 (4%) 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%) 6 (12%) 2 (4%)
Congestion 1 (2%)
Eosinophilic Focus 9 (18%) 3 (6%) 4 (8%) 5 (10%)
Hematopoietic Cell Proliferation 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 15 (30%) 17 (34%) 18 (36%) 20 (40%)
Mixed Cell Focus 1 (2%) 4 (8%) 2 (4%)
Necrosis, Focal 4 (8%) 1 (2%) 5 (10%) 7 (14%)
Pigmentation, Focal 2 (4%) 1 (2%) 3 (6%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 8 (16%) 9 (18%) 8 (16%) 7 (14%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Karyomegaly 12 (24%) 14 (28%) 8 (16%) 12 (24%)
Mesentery (7) (5) (6) (9)
Angiectasis 1 (14%) 1 (20%)
Inflammation, Chronic 1 (14%) 1 (20%) 2 (33%) 3 (33%)
Artery, Inflammation, Chronic 2 (29%) 1 (17%) 4 (44%)
Fat, Necrosis 1 (14%)
Pancreas (49) (49) (49) (49)
Inflammation, Chronic 1 (2%) 1 (2%)
Acinus, Atrophy, Diffuse 2 (4%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (50) (48) (49) (50)
Diverticulum 1 (2%) 1 (2%) 1 (2%)
Erosion 2 (4%) 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 3 (6%) 2 (4%) 4 (8%) 1 (2%)
Epithelium, Cyst 1 (2%)
Epithelium, Hyperplasia 5 (10%) 3 (6%) 5 (10%) 2 (4%)
Muscularis, Serosa, Inflammation, Suppurative 1 (2%)
Stomach, Glandular (50) (48) (49) (50)
Erosion 2 (4%) 1 (2%)
Inflammation, Chronic 2 (4%)
Metaplasia, Hepatocyte 1 (2%) 1 (2%)
Mineralization 1 (2%)
Pigmentation, Focal 1 (2%) 2 (4%) 3 (6%)
Epithelium, Hyperplasia 2 (4%)
Glands, Degeneration, Cystic, Focal 2 (4%) 2 (4%) 1 (2%)
Muscularis, Serosa, Inflammation, Suppurative 1 (2%)
Tooth (24) (14) (24) (20)
Developmental Malformation 24 (100%) 14 (100%) 24 (100%) 20 (100%)
Inflammation, Chronic, Suppurative 1 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (48) (50)
Mineralization 1 (2%)
Heart (50) (50) (50) (50)
Mineralization 1 (2%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (49)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) 1 (2%)
Angiectasis 1 (2%)
Cyst 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 3 (6%) 2 (4%) 5 (10%) 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Capsule, Hyperplasia, Focal 3 (6%) 10 (20%) 3 (6%) 6 (12%)
Adrenal Medulla (49) (49) (50) (49)
Hyperplasia 6 (12%) 1 (2%) 1 (2%) 3 (6%)
Islets, Pancreatic (50) (48) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (49) (41) (45) (43)
Cyst 1 (2%) 2 (4%) 1 (2%)
Pituitary Gland (45) (47) (47) (41)
Pars Distalis, Cyst 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Pars Distalis, Cytoplasmic Alteration, Focal 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia, Focal 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Degeneration, Cystic, Focal 3 (6%) 3 (6%) 7 (14%) 4 (8%)
Inflammation, Chronic, Focal 1 (2%)
C-Cell, Hyperplasia 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 7 (14%) 6 (12%) 11 (22%) 8 (16%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2)
Inflammation, Chronic 1 (50%)
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization, Focal 1 (2%)
Spermatocele 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (50)
Degeneration, Cystic 17 (34%) 16 (32%) 14 (28%) 11 (22%)
Inflammation, Chronic 2 (4%) 3 (6%) 6 (12%) 5 (10%)
Prostate (49) (49) (50) (49)
Inflammation, Chronic, Focal 2 (4%) 2 (4%) 4 (8%)
Epithelium, Hyperplasia, Focal 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Testes (50) (50) (50) (50)
Cyst 1 (2%)
Mineralization, Focal 2 (4%)
Germinal Epithelium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Angiectasis 1 (2%)
Hyperplasia 2 (4%) 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Lymph Node (3) (3) (6) (3)
Iliac, Hyperplasia 1 (33%)
Inguinal, Hyperplasia 1 (17%) 1 (33%)
Inguinal, Hyperplasia, Lymphoid 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inguinal, Pigmentation 1 (33%)
Lymph Node, Mandibular (47) (46) (45) (45)
Hyperplasia 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (48) (46) (50)
Angiectasis 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%) 3 (7%) 5 (10%)
Hemorrhage 13 (26%) 9 (19%) 15 (33%) 12 (24%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 4 (9%) 4 (8%)
Spleen (49) (49) (49) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 21 (43%) 19 (39%) 16 (33%) 15 (30%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Thymus (38) (38) (35) (39)
Cyst 2 (5%) 5 (13%) 4 (11%) 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (49) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Artery, Subcutaneous Tissue, Inflammation,
Chronic 1 (2%)
Hair Follicle, Atrophy 2 (4%)
Subcutaneous Tissue, Angiectasis, Focal 1 (2%)
Subcutaneous Tissue, Edema 2 (4%) 3 (6%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1 (2%)
Hyperostosis 1 (2%)
Skeletal Muscle (50) (50) (50) (50)
Hemorrhage, Focal 1 (2%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Spinal Cord (1) (2) (4) (2)
Hemorrhage, Focal 1 (25%) 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Histiocytic 4 (8%) 2 (4%) 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Bronchus, Glands, Cyst 3 (6%) 1 (2%)
Mediastinum, Hemorrhage 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Mucosa, Polyp, Inflammatory 2 (4%) 2 (4%)
Mucosa, Glands, Dilatation, Focal 25 (50%) 24 (48%) 26 (52%) 26 (52%)
Nasolacrimal Duct, Cyst 1 (2%)
Nasolacrimal Duct, Dilatation 1 (2%)
Nasopharyngeal Duct, Hyperplasia, Focal 1 (2%)
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SPECIAL SENSES SYSTEM
Harderian Gland (4) (6) (8) (4)
Degeneration, Cystic, Focal 1 (13%)
Hyperplasia, Focal 1 (13%)
Inflammation, Chronic, Focal 1 (25%) 1 (13%)
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URINARY SYSTEM
Kidney (49) (49) (49) (50)
Congestion 1 (2%) 1 (2%)
Cyst 1 (2%)
Infarct 2 (4%) 2 (4%)
Metaplasia, Focal, Osseous 2 (4%) 4 (8%)
Nephropathy 46 (94%) 44 (90%) 46 (94%) 49 (98%)
Artery, Inflammation, Chronic 1 (2%)
Pelvis, Dilatation 2 (4%) 3 (6%) 1 (2%)
Renal Tubule, Dilatation 1 (2%) 2 (4%) 3 (6%)
Renal Tubule, Pigmentation 1 (2%) 2 (4%)
Urethra (9) (14) (16) (15)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89006-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 12/23/96
Route: SUBCUTANEOUS Time: 17:05:47
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B6C3F1 MICE MALE VEHICLE 500 U 5000 U 5000 U A
CONTROL A/D A/D
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URINARY SYSTEM - CONT
Inflammation, Chronic 2 (22%) 6 (43%) 4 (25%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
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