TDMS Study 89006-08 Pathology Tables
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
VEHICLE CONTROL VS. 5000 U/A
Facility: Southern Research Institute
Chemical CAS #: 76543-88-9
Lock Date: 09/03/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 VEHICLE CONTROL
Include 008 5000 U A
Include 001 VEHICLE CONTROL
Include 007 5000 U A
Page 1
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 8| 0| 5| 0| 8| 2| 3| 2| 3| 2| 3| 2| 2| 3| 9| 2| 7| 7| 5| 2| 3| 2|
| 9| 1| 9| 5| 9| 4| 8| 1| 9| 1| 9| 1| 9| 1| 9| 7| 1| 9| 9| 8| 3| 5| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + I + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | |
Congestion | 3 |
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 3 2|
Mixed Cell Focus | 3 2 |
Necrosis, Focal | 4 3 3 |
Pigmentation, Focal | 1 1 |
Vacuolization Cytoplasmic | 3 2 4 2 |
Artery, Inflammation, Chronic | |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Karyomegaly | 2 2|
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Artery, Inflammation, Chronic | |
Fat, Necrosis | 3 3 3 3 2 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Erosion | 1 2 1 2 |
Inflammation, Chronic | 1 2 |
Epithelium, Hyperplasia | 2 2 2 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Mineralization | |
Pigmentation, Focal | 1 |
Artery, Inflammation, Chronic | |
Glands, Degeneration, Cystic, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 8| 0| 5| 0| 8| 2| 3| 2| 3| 2| 3| 2| 2| 3| 9| 2| 7| 7| 5| 2| 3| 2|
| 9| 1| 9| 5| 9| 4| 8| 1| 9| 1| 9| 1| 9| 1| 9| 7| 1| 9| 9| 8| 3| 5| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cyst | |
Capsule, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 2|
Follicle, Cyst | 2 2 |
Follicular Cell, Hyperplasia | 2 2 3 2 3 1 2 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 4 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 4 3 3 |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Focal, Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hemorrhage | |
Inguinal, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 8| 0| 5| 0| 8| 2| 3| 2| 3| 2| 3| 2| 2| 3| 9| 2| 7| 7| 5| 2| 3| 2|
| 9| 1| 9| 5| 9| 4| 8| 1| 9| 1| 9| 1| 9| 1| 9| 7| 1| 9| 9| 8| 3| 5| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + + M + + +|
Angiectasis | 4 |
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 3 3 2 3 3 2 3 3 2|
Hyperplasia, Lymphoid | |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + I + + + M + + + + + + + + M + + +|
Cyst | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | |
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoporosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2|
Hemorrhage, Focal | 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 |
Hyperplasia, Histiocytic | 2 1 2|
Hyperplasia, Lymphoid | 2 |
Pigmentation, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 8| 0| 5| 0| 8| 2| 3| 2| 3| 2| 3| 2| 2| 3| 9| 2| 7| 7| 5| 2| 3| 2|
| 9| 1| 9| 5| 9| 4| 8| 1| 9| 1| 9| 1| 9| 1| 9| 7| 1| 9| 9| 8| 3| 5| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 2 2 2 2 1 1 1 2 2 2 2 2 1 1 2 2 2 2 2 1|
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Metaplasia, Focal, Osseous | 1 1 |
Nephropathy | 2 1 2 1 1 1 3 1 1 1 1 2 1 2 1 1|
Artery, Inflammation, Chronic | |
Pelvis, Dilatation | 2 |
Renal Tubule, Dilatation | 2 2 |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urethra | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 3| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 7| 8| 6| 2| 3| 2| 3| 2| 9| 5| 7| 7| 2| 3| 3| 2| 6| 3| 3| 2| 0| 7| 0| 4| 3| |
| 1| 9| 7| 9| 3| 9| 1| 9| 7| 1| 5| 1| 9| 1| 1| 9| 5| 1| 8| 9| 8| 3| 1| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + + M + A + M + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + A + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + A + + + + + + + + + + A + +| 47 |
Artery, Inflammation, Chronic | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + A + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + + + A + +| 47 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Liver | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Clear Cell Focus | 1 | 1 1.0|
Congestion | | 1 3.0|
Eosinophilic Focus | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Inflammation, Chronic | 1 1 | 4 1.8|
Mixed Cell Focus | 3 3 | 4 2.8|
Necrosis, Focal | | 3 3.3|
Pigmentation, Focal | | 2 1.0|
Vacuolization Cytoplasmic | 3 | 5 2.8|
Artery, Inflammation, Chronic | 2| 1 2.0|
Bile Duct, Hyperplasia | | 1 1.0|
Hepatocyte, Karyomegaly | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + +| 21 |
Artery, Inflammation, Chronic | 2| 1 2.0|
Fat, Necrosis | 1 3 3 3 3 3 | 13 2.8|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Diverticulum | 1 | 2 1.5|
Erosion | 1 | 5 1.4|
Inflammation, Chronic | 1 | 3 1.3|
Epithelium, Hyperplasia | 1 2 | 7 1.9|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Erosion | | 1 1.0|
Mineralization | 2 | 1 2.0|
Pigmentation, Focal | | 1 1.0|
Artery, Inflammation, Chronic | 2| 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 3| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 7| 8| 6| 2| 3| 2| 3| 2| 9| 5| 7| 7| 2| 3| 3| 2| 6| 3| 3| 2| 0| 7| 0| 4| 3| |
| 1| 9| 7| 9| 3| 9| 1| 9| 7| 1| 5| 1| 9| 1| 1| 9| 5| 1| 8| 9| 8| 3| 1| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Glands, Degeneration, Cystic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 | 3 1.0|
Cyst | 1| 1 1.0|
Capsule, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + M + M + + + M + + + + + M + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + M + + + + + + +| 46 |
Angiectasis | | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 2 1 2 2 | 8 1.6|
Follicle, Cyst | | 2 2.0|
Follicular Cell, Hyperplasia | 2 2 1 2 3 2 3 | 17 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 2 |
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + M +| 48 |
Degeneration, Cystic | 3 | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + M + + M M M + + + + + + + + + + + + + + + +| 46 |
Cyst | 2 2 3 2 2| 10 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 3 3 3 3 | 10 3.0|
Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 48 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 3| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 7| 8| 6| 2| 3| 2| 3| 2| 9| 5| 7| 7| 2| 3| 3| 2| 6| 3| 3| 2| 0| 7| 0| 4| 3| |
| 1| 9| 7| 9| 3| 9| 1| 9| 7| 1| 5| 1| 9| 1| 1| 9| 5| 1| 8| 9| 8| 3| 1| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + A + + + + + + + + + M + + +| 48 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 12 |
Iliac, Hemorrhage | 3 | 1 3.0|
Inguinal, Hyperplasia | 2 2 | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Renal, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + + + + + A + + + + + + M + + + + + +| 45 |
Angiectasis | | 1 4.0|
Hemorrhage | | 2 2.5|
Hyperplasia, Lymphoid | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | 2 4 2 3 3 3 1 2 2 4 4 | 21 2.6|
Hyperplasia, Lymphoid | 2 2 3| 3 2.3|
Necrosis, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + M M M + + I + + + A + + + + + + + + M + + + +| 41 |
Cyst | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
Artery, Subcutaneous Tissue, | | |
Inflammation, Chronic | 2| 1 2.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteoporosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 3| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 7| 8| 6| 2| 3| 2| 3| 2| 9| 5| 7| 7| 2| 3| 3| 2| 6| 3| 3| 2| 0| 7| 0| 4| 3| |
| 1| 9| 7| 9| 3| 9| 1| 9| 7| 1| 5| 1| 9| 1| 1| 9| 5| 1| 8| 9| 8| 3| 1| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 2 2.0|
Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.0|
Hyperplasia, Histiocytic | 4 | 4 2.3|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Glands, Dilatation, Focal | 1 1 2 2 2 1 2 1 1 3 1 2 1 1 2 2 2 2 2 1 2| 41 1.7|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Cyst | 3 | 1 3.0|
Metaplasia, Focal, Osseous | 1 | 3 1.0|
Nephropathy | 1 1 1 1 2 1 1 2 2 1 1 1 2| 29 1.3|
Artery, Inflammation, Chronic | 2| 1 2.0|
Pelvis, Dilatation | 2 | 2 2.0|
Renal Tubule, Dilatation | | 2 2.0|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | +| 1 |
Artery, Inflammation, Chronic | 2| 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 2| 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 6| 0| 2| 0| 3| 8| 3| 2| 3| 3| 4| 2| 1| 2| 0| 2| 3| 2| 3| 2| 3| 3| 6|
| 9| 9| 7| 8| 9| 2| 1| 3| 1| 6| 1| 1| 9| 9| 2| 0| 1| 9| 1| 9| 1| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 U A | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | 1 |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 1 1 1 2 |
Mixed Cell Focus | 2 |
Necrosis, Focal | |
Pigmentation, Focal | 1 |
Vacuolization Cytoplasmic | 2 1 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + A + + + + + + +|
Artery, Inflammation, Chronic | 2 |
Fat, Necrosis | 2 3 2 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + + + M + + + + + + + + + +|
Edema | 2 |
Erosion | |
Inflammation, Chronic | 1 |
Epithelium, Cyst | |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + M + + + + + + + + + +|
Erosion | 2 |
Glands, Degeneration, Cystic, Focal | 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + M +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 6| 0| 2| 0| 3| 8| 3| 2| 3| 3| 4| 2| 1| 2| 0| 2| 3| 2| 3| 2| 3| 3| 6|
| 9| 9| 7| 8| 9| 2| 1| 3| 1| 6| 1| 1| 9| 9| 2| 0| 1| 9| 1| 9| 1| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 U A | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Hyperplasia | 4 |
Hypertrophy, Focal | |
Capsule, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + M + I M + + + + + + + + I + + + M + + M + +|
Angiectasis | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 2 2 |
Inflammation, Chronic, Focal | |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 1 2 2 1 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | 3 3 |
Atrophy | 3 |
Cyst | 1 3 2 3 2 3 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 2 3 3 3 3 3 |
Inflammation, Suppurative | |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 2 3 3 2 3 3 3 3 3 3 3 3 3 3 4 3 2|
__________________________________________________________________________|
Vagina | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Iliac, Hyperplasia | 3 |
Inguinal, Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 6| 0| 2| 0| 3| 8| 3| 2| 3| 3| 4| 2| 1| 2| 0| 2| 3| 2| 3| 2| 3| 3| 6|
| 9| 9| 7| 8| 9| 2| 1| 3| 1| 6| 1| 1| 9| 9| 2| 0| 1| 9| 1| 9| 1| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 U A | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Inflammation, Focal, | |
Suppurative | 4 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 3 3 2 3 2 2 4 3 3 3 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + A + + + + + + + + I + + + M + M M +|
Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage, | |
Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 1 |
Mediastinum, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 6| 0| 2| 0| 3| 8| 3| 2| 3| 3| 4| 2| 1| 2| 0| 2| 3| 2| 3| 2| 3| 3| 6|
| 9| 9| 7| 8| 9| 2| 1| 3| 1| 6| 1| 1| 9| 9| 2| 0| 1| 9| 1| 9| 1| 9| 1| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 U A | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Glands, Dilatation, Focal | 1 2 1 2 2 2 2 3 3 1 1 1 2 2 2 2 1 2 2 3 1 2 1|
Nasolacrimal Duct, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 |
Pelvis, Dilatation | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2|
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 7| 2| 3| 3| 2| 3| 8| 6| 2| 4| 2| 3| 3| 1| 3| 2| 2| 0| 0| 4| 3| |
| 1| 1| 9| 1| 5| 9| 6| 1| 9| 1| 2| 3| 9| 9| 9| 1| 1| 5| 1| 9| 9| 8| 7| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 U A | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + A + + + + + M +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 1.7|
Basophilic Focus | | 1 1.0|
Eosinophilic Focus | 3 3 3 2 2 3 2| 8 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | 1 1 1 1| 9 1.2|
Mixed Cell Focus | | 1 2.0|
Necrosis, Focal | 2 3 3 | 3 2.7|
Pigmentation, Focal | | 1 1.0|
Vacuolization Cytoplasmic | | 3 1.7|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 16 |
Artery, Inflammation, Chronic | 2| 2 2.0|
Fat, Necrosis | 3 3 2 3 | 10 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + M +| 46 |
Edema | | 1 2.0|
Erosion | 2 | 1 2.0|
Inflammation, Chronic | 2 2 | 3 1.7|
Epithelium, Cyst | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + M +| 46 |
Erosion | | 1 2.0|
Glands, Degeneration, Cystic, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 7| 2| 3| 3| 2| 3| 8| 6| 2| 4| 2| 3| 3| 1| 3| 2| 2| 0| 0| 4| 3| |
| 1| 1| 9| 1| 5| 9| 6| 1| 9| 1| 2| 3| 9| 9| 9| 1| 1| 5| 1| 9| 9| 8| 7| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 U A | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
Artery, Inflammation, Chronic | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cytoplasmic Alteration, Focal | 1 | 1 1.0|
Hyperplasia | | 1 4.0|
Hypertrophy, Focal | 2 | 1 2.0|
Capsule, Hyperplasia, Focal | 2| 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + M + + + + + + +| 47 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 43 |
Angiectasis | 2 1 2 | 3 1.7|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 | 2 1.5|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 1 3 1 | 8 1.8|
Inflammation, Chronic, Focal | 2 | 1 2.0|
C-Cell, Hyperplasia | 3 | 1 3.0|
Follicular Cell, Hyperplasia | 2 3 1 2 1 1 1 | 14 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Degeneration, Cystic | 3 3 3| 6 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Angiectasis | 3 | 3 3.0|
Atrophy | | 1 3.0|
Cyst | 3 2 | 8 2.4|
Bilateral, Cyst | 4| 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 3 3 2 3 3 4 3 4 3 3 3| 20 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 7| 2| 3| 3| 2| 3| 8| 6| 2| 4| 2| 3| 3| 1| 3| 2| 2| 0| 0| 4| 3| |
| 1| 1| 9| 1| 5| 9| 6| 1| 9| 1| 2| 3| 9| 9| 9| 1| 1| 5| 1| 9| 9| 8| 7| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 U A | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 1 3.0|
Thrombosis | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3| 48 2.9|
__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + M + + M + + + + + + + + + M +| 46 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 11 |
Iliac, Hyperplasia | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia | | 1 3.0|
Mediastinal, Inflammation, Focal, | | |
Suppurative | | 1 4.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + M +| 47 |
Ectasia | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 1 2 3 1 3 | 20 2.7|
Hyperplasia, Lymphoid | 2 2 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + + + + I + + + I + + + M + M +| 39 |
Hyperplasia, Histiocytic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 | 2 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Hemorrhage, | | |
Focal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 7| 2| 3| 3| 2| 3| 8| 6| 2| 4| 2| 3| 3| 1| 3| 2| 2| 0| 0| 4| 3| |
| 1| 1| 9| 1| 5| 9| 6| 1| 9| 1| 2| 3| 9| 9| 9| 1| 1| 5| 1| 9| 9| 8| 7| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 U A | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Histiocytic | 3 4 1 | 3 2.7|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Mediastinum, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
Mucosa, Glands, Dilatation, Focal | 2 1 2 2 3 2 2 2 1 2 2 2 2 2 2 2 1| 40 1.8|
Nasolacrimal Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Nephropathy | 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1| 31 1.1|
Pelvis, Dilatation | 3 | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 2 2.5|
Renal Tubule, Pigmentation | 3| 2 2.5|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 6| 5| 3| 2| 3| 0| 2| 0| 7| 2| 3| 3| 2| 3| 3| 2| 0| 0| 2| 3| 3| 3|
| 6| 8| 3| 6| 3| 0| 8| 0| 0| 8| 5| 3| 8| 0| 0| 6| 0| 0| 8| 3| 5| 8| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Eosinophilic Focus | 2 3|
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Inflammation, Chronic | 3 3 1 3 2 2 |
Mixed Cell Focus | 3 |
Necrosis, Focal | 2 3 1 |
Pigmentation, Focal | 2 1 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Hyperplasia | 3 3 2 2 |
Hepatocyte, Karyomegaly | 3 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Angiectasis | 2 |
Inflammation, Chronic | 1 |
Artery, Inflammation, Chronic | 2 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Erosion | |
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Hepatocyte | |
Glands, Degeneration, Cystic, Focal | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + +|
Developmental Malformation | 2 2 1 3 3 3 4 4 4 1 3 3 2|
Inflammation, Chronic, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 6| 5| 3| 2| 3| 0| 2| 0| 7| 2| 3| 3| 2| 3| 3| 2| 0| 0| 2| 3| 3| 3|
| 6| 8| 3| 6| 3| 0| 8| 0| 0| 8| 5| 3| 8| 0| 0| 6| 0| 0| 8| 3| 5| 8| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Thrombosis | 4 |
Artery, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Cyst | 1 |
Cytoplasmic Alteration, Focal | 2 1 2 |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | |
Capsule, Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 4 3 3 2 2 3 2 3 3|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 6| 5| 3| 2| 3| 0| 2| 0| 7| 2| 3| 3| 2| 3| 3| 2| 0| 0| 2| 3| 3| 3|
| 6| 8| 3| 6| 3| 0| 8| 0| 0| 8| 5| 3| 8| 0| 0| 6| 0| 0| 8| 3| 5| 8| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + M + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 3 2 2 3 2 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 3 2 2 3 3 3 3 |
__________________________________________________________________________|
Thymus | + + I + + + + + M M + M M + + + + M + + + + + + +|
Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
Hyperostosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Polyp, Inflammatory | 2 2 |
Mucosa, Glands, Dilatation, Focal | 1 2 1 2 2 1 1 1 1 2 2|
Nasolacrimal Duct, Cyst | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 6| 5| 3| 2| 3| 0| 2| 0| 7| 2| 3| 3| 2| 3| 3| 2| 0| 0| 2| 3| 3| 3|
| 6| 8| 3| 6| 3| 0| 8| 0| 0| 8| 5| 3| 8| 0| 0| 6| 0| 0| 8| 3| 5| 8| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | 2|
Metaplasia, Focal, Osseous | 2 2 |
Nephropathy | 1 2 1 2 2 1 1 3 2 1 2 2 2 4 1 2 2 2 2 2 2 2|
Artery, Inflammation, Chronic | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 4 |
__________________________________________________________________________|
Urethra | + + + + + + + |
Inflammation, Chronic | 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 6| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 9| 2| 0| 8| 7| 6| 2| 6| 7| 2| 2| 8| 3| 2| 7| 2| 2| 1| 2| 3| 2| 2| 8| 3| 3| |
| 6| 8| 7| 2| 1| 9| 8| 4| 3| 8| 8| 2| 0| 8| 3| 6| 6| 7| 8| 0| 8| 8| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + M + + + + + + + + + + M + + + + M| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Clear Cell Focus | 4 | 1 4.0|
Eosinophilic Focus | 3 1 2 4 2 1 1| 9 2.1|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Infarct | | 1 4.0|
Inflammation, Chronic | 2 2 2 2 3 1 3 3 2| 15 2.3|
Mixed Cell Focus | | 1 3.0|
Necrosis, Focal | 2 | 4 2.0|
Pigmentation, Focal | | 2 1.5|
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Hyperplasia | 1 2 2 2| 8 2.1|
Hepatocyte, Karyomegaly | 3 2 3 3 2 3 3 | 12 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Angiectasis | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Artery, Inflammation, Chronic | | 2 2.5|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 2.0|
Erosion | 1 1 | 2 1.0|
Inflammation, Chronic | 1 1 1 | 3 1.0|
Epithelium, Hyperplasia | 1 1 1 2 1 | 5 1.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Hepatocyte | 1 | 1 1.0|
Glands, Degeneration, Cystic, Focal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + | 24 |
Developmental Malformation | 3 1 3 1 3 2 2 3 3 2 4 | 24 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 6| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 9| 2| 0| 8| 7| 6| 2| 6| 7| 2| 2| 8| 3| 2| 7| 2| 2| 1| 2| 3| 2| 2| 8| 3| 3| |
| 6| 8| 7| 2| 1| 9| 8| 4| 3| 8| 8| 2| 0| 8| 3| 6| 6| 7| 8| 0| 8| 8| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
Thrombosis | | 1 4.0|
Artery, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2| 1 2.0|
Angiectasis | 2 | 1 2.0|
Cyst | | 1 1.0|
Cytoplasmic Alteration, Focal | | 3 1.7|
Hyperplasia, Focal | 2| 1 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Capsule, Hyperplasia, Focal | 2 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2| 6 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M M + + + + + + + + + + + + I + + I + + + +| 45 |
Pars Distalis, Cyst | 2 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 1 | 3 1.7|
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 1 2 1 2| 7 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 6| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 9| 2| 0| 8| 7| 6| 2| 6| 7| 2| 2| 8| 3| 2| 7| 2| 2| 1| 2| 3| 2| 2| 8| 3| 3| |
| 6| 8| 7| 2| 1| 9| 8| 4| 3| 8| 8| 2| 0| 8| 3| 6| 6| 7| 8| 0| 8| 8| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Degeneration, Cystic | 3 3 2 2 4 3 3 3 | 17 2.8|
Inflammation, Chronic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Inflammation, Chronic, Focal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 3 2.7|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hemorrhage | 1 3 3 2 3 3 | 13 2.3|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3 3 3 3 2| 21 2.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + M + I M + M M + +| 38 |
Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Subcutaneous Tissue, | | |
Inflammation, Chronic | 1 | 1 1.0|
Subcutaneous Tissue, Edema | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fracture | 3 | 1 3.0|
Hyperostosis | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 6| 6| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 9| 2| 0| 8| 7| 6| 2| 6| 7| 2| 2| 8| 3| 2| 7| 2| 2| 1| 2| 3| 2| 2| 8| 3| 3| |
| 6| 8| 7| 2| 1| 9| 8| 4| 3| 8| 8| 2| 0| 8| 3| 6| 6| 7| 8| 0| 8| 8| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Hyperplasia, Histiocytic | 3 3 3 | 4 2.8|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Thrombosis | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Mucosa, Polyp, Inflammatory | | 2 2.0|
Mucosa, Glands, Dilatation, Focal | 1 1 1 1 1 2 3 1 2 3 1 2 2 3 | 25 1.6|
Nasolacrimal Duct, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Inflammation, Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 3.0|
Cyst | | 1 2.0|
Metaplasia, Focal, Osseous | | 2 2.0|
Nephropathy | 2 2 2 1 1 2 1 4 2 2 3 1 2 1 4 3 1 2 2 2 2 2 2 1| 46 1.9|
Artery, Inflammation, Chronic | | 1 2.0|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Urethra | + +| 9 |
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 6| 2| 3| 6| 2| 2| 3| 3| 7| 2| 3| 3| 3| 2| 3| 9| 0| 4| 2| 9| 2| 3|
| 8| 0| 8| 7| 8| 3| 6| 4| 8| 0| 0| 8| 8| 0| 0| 0| 8| 0| 1| 0| 0| 8| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 U A | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + M + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | 2 2 3 4 |
Inflammation, Chronic | 2 2 3 2 2 2 2 2 2 2 2 2|
Mixed Cell Focus | |
Necrosis, Focal | 3 1 4 |
Pigmentation, Focal | 2 3 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 2 1 1 2 1 1|
Centrilobular, Necrosis | 3 |
Hepatocyte, Karyomegaly | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + +|
Inflammation, Chronic | 2 2 |
Artery, Inflammation, Chronic | 1 3 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Pigmentation, Focal | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + |
Developmental Malformation | 2 3 3 2 3 3 1 3 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 6| 2| 3| 6| 2| 2| 3| 3| 7| 2| 3| 3| 3| 2| 3| 9| 0| 4| 2| 9| 2| 3|
| 8| 0| 8| 7| 8| 3| 6| 4| 8| 0| 0| 8| 8| 0| 0| 0| 8| 0| 1| 0| 0| 8| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 U A | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | |
Capsule, Hyperplasia, Focal | 1 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + M + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + M + + +|
Pars Distalis, Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 1 1 |
Follicular Cell, Hyperplasia | 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 3 3 3 |
Inflammation, Chronic | 3 3 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | +|
Iliac, Hyperplasia | 3|
Inguinal, Hyperplasia | 2|
Inguinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + M + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 2 3 1 3 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 2 3 2 3|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 6| 2| 3| 6| 2| 2| 3| 3| 7| 2| 3| 3| 3| 2| 3| 9| 0| 4| 2| 9| 2| 3|
| 8| 0| 8| 7| 8| 3| 6| 4| 8| 0| 0| 8| 8| 0| 0| 0| 8| 0| 1| 0| 0| 8| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 U A | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + + + M I + + + M M + + +|
Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Subcutaneous Tissue, Angiectasis, | |
Focal | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | 3 |
Alveolar Epithelium, Hyperplasia | |
Bronchus, Glands, Cyst | 1 |
Mediastinum, Hemorrhage | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Mucosa, Polyp, Inflammatory | |
Mucosa, Glands, Dilatation, Focal | 2 2 1 1 2 2 1 2 1 1 1 2 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Nephropathy | 2 2 2 1 1 1 2 1 2 2 1 2 2 2 2 1 2 1 2 1 2 2 4 2 2|
Pelvis, Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 6| 2| 3| 6| 2| 2| 3| 3| 7| 2| 3| 3| 3| 2| 3| 9| 0| 4| 2| 9| 2| 3|
| 8| 0| 8| 7| 8| 3| 6| 4| 8| 0| 0| 8| 8| 0| 0| 0| 8| 0| 1| 0| 0| 8| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 U A | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation | 2 3 2 |
Renal Tubule, Pigmentation | 2 3 |
__________________________________________________________________________|
Urethra | + + + + + + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 5| 8| 3| 2| 2| 2| 3| 4| 5| 2| 4| 2| 8| 5| 2| 3| 0| 2| 7| 2| 0| 3| |
| 8| 0| 2| 4| 5| 0| 8| 5| 8| 0| 4| 8| 2| 7| 8| 0| 8| 8| 0| 7| 3| 5| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
5000 U A | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M M + + + + + + + + + + M + + + + + M + + I + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | 2 | 1 2.0|
Clear Cell Focus | 2 2 | 2 2.0|
Eosinophilic Focus | 2 | 5 2.6|
Inflammation, Chronic | 2 3 1 3 1 2 2 3 | 20 2.1|
Mixed Cell Focus | 3 1 | 2 2.0|
Necrosis, Focal | 1 2 1 3 | 7 2.1|
Pigmentation, Focal | 3 | 3 2.7|
Vacuolization Cytoplasmic | | 1 2.0|
Bile Duct, Hyperplasia | 1 | 7 1.3|
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Karyomegaly | 2 2 2 3 | 12 2.1|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Inflammation, Chronic | 2 | 3 2.0|
Artery, Inflammation, Chronic | | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 2 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
Pigmentation, Focal | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + | 20 |
Developmental Malformation | 3 3 1 3 3 3 3 1 3 3 | 20 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 5| 8| 3| 2| 2| 2| 3| 4| 5| 2| 4| 2| 8| 5| 2| 3| 0| 2| 7| 2| 0| 3| |
| 8| 0| 2| 4| 5| 0| 8| 5| 8| 0| 4| 8| 2| 7| 8| 0| 8| 8| 0| 7| 3| 5| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
5000 U A | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration, Focal | 1 | 1 1.0|
Capsule, Hyperplasia, Focal | 1 2 2 | 6 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + + + + + + M + + + + M + + M + + + +| 43 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + M M + M M + + + M + M| 41 |
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | | 4 1.3|
Follicular Cell, Hyperplasia | 1 2 1 3 | 8 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 3 3 3 | 11 2.8|
Inflammation, Chronic | 3 3 | 5 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
Iliac, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 5| 8| 3| 2| 2| 2| 3| 4| 5| 2| 4| 2| 8| 5| 2| 3| 0| 2| 7| 2| 0| 3| |
| 8| 0| 2| 4| 5| 0| 8| 5| 8| 0| 4| 8| 2| 7| 8| 0| 8| 8| 0| 7| 3| 5| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
5000 U A | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Hyperplasia | | 1 2.0|
Inguinal, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + M + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 2 2 3 2 | 5 2.2|
Hemorrhage | 1 3 3 2 2 3 3 | 12 2.3|
Hyperplasia, Lymphoid | 2 3 | 4 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 2 3 3 3 3 | 15 2.8|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + M I + M + + + M + + + + + + + + + + +| 39 |
Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M + M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 2.0|
Subcutaneous Tissue, Angiectasis, | | |
Focal | 2 | 1 2.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Hemorrhage, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 2 2.0|
Hyperplasia, Histiocytic | 3 | 2 3.0|
Alveolar Epithelium, Hyperplasia | 2 1| 2 1.5|
Bronchus, Glands, Cyst | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 89006-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC INTERFERON A/INTERFERON AD Date: 08/24/96
Route: SUBCUTANEOUS Time: 01:00:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 2| 3| 3| 5| 8| 3| 2| 2| 2| 3| 4| 5| 2| 4| 2| 8| 5| 2| 3| 0| 2| 7| 2| 0| 3| |
| 8| 0| 2| 4| 5| 0| 8| 5| 8| 0| 4| 8| 2| 7| 8| 0| 8| 8| 0| 7| 3| 5| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
5000 U A | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Mucosa, Polyp, Inflammatory | 2 3 | 2 2.5|
Mucosa, Glands, Dilatation, Focal | 1 2 1 2 1 1 2 1 2 2 2 | 26 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Nephropathy | 2 1 1 1 2 1 1 2 2 1 1 1 1 2 2 1 1 3 1 1 1 1 2 1| 49 1.6|
Pelvis, Dilatation | | 1 4.0|
Renal Tubule, Dilatation | | 3 2.3|
Renal Tubule, Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Urethra | + + + + + + + +| 15 |
Inflammation, Chronic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
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---------- END OF REPORT ----------
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