TDMS Study 89006-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst INTERFERON A/INTERFERON AD DATE: 12/30/96
EXPERIMENT: 89006 TEST: 08 TIME: 17:14:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-85225 ROUTE: SUBCUTANEOUS NTP C#: C89001
PATHOLOGIST: MISSING CAS: 76543-88-9
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst INTERFERON A/INTERFERON AD DATE: 12/30/96
EXPERIMENT: 89006 TEST: 08 TIME: 17:14:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-85225 ROUTE: SUBCUTANEOUS NTP C#: C89001
PATHOLOGIST: MISSING CAS: 76543-88-9
INTERFERON A/INTERFERON AD
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 405 469 503 566 582 586 596 603 605 626 |
| 626 626 653 664 671 673 673 673 682 689 |
| 700 707 717 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 U A/D |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 405 489 507 538 540 547 552 558 564 573 |
| 580 580 590 615 622 637 653 654 661 664 |
| 667 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 U A/D |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 435 486 524 556 563 571 572 583 585 587 |
| 588 615 619 633 649 656 689 689 694 699 |
| 721 |
| CENSORED DEATHS |
| 113 |
| |
==================================================================================
INTERFERON A/INTERFERON AD
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 U A |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 524 532 533 544 547 566 567 580 591 609 |
| 640 654 658 658 675 678 685 695 700 707 |
| 722 723 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INTERFERON A/INTERFERON AD
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 82.0 72.0 54.0 |
|CONTROL | |
| | |
|500 U A/D| 100.0 100.0 100.0 100.0 98.0 98.0 90.0 74.0 60.0 56.0 |
| | |
| | |
|5000 U A/D| 100.0 100.0 100.0 100.0 100.0 98.0 93.9 77.6 67.3 57.1 |
| | |
| | |
|5000 U A | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 82.0 72.0 54.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 500 U A/D 5000 U A/D 5000 U A |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.0% 56.0% 57.1% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=0.973 P=1.000N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 621.5 587.1 605.4 631.0 |
|NATURAL DEATHS (C) | (16.4) (15.2) (16.0) (14.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 679.0 666.0 664.2 683.4 |
|(STANDARD ERROR) | (10.6) (12.0) (15.6) ( 9.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
INTERFERON A/INTERFERON AD
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 365 409 533 567 597 601 638 649 651 654 |
| 655 671 671 673 673 675 678 681 685 689 |
| 699 708 708 721 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 U A/D |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 483 553 577 610 623 645 654 658 685 685 |
| 686 687 698 701 704 715 720 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 U A/D |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 1 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 22 293 506 564 567 581 583 604 624 632 |
| 652 652 654 659 659 660 667 672 678 683 |
| 685 691 715 727 |
| CENSORED DEATHS |
| 1 |
| |
==================================================================================
INTERFERON A/INTERFERON AD
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 U A |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 149 426 449 483 563 563 567 575 601 612 |
| 615 636 642 682 702 707 708 708 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
INTERFERON A/INTERFERON AD
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 96.0 96.0 94.0 88.0 78.0 50.0 |
|CONTROL | |
| | |
|500 U A/D| 100.0 100.0 100.0 100.0 100.0 98.0 98.0 94.0 84.0 64.0 |
| | |
| | |
|5000 U A/D| 98.0 98.0 98.0 95.9 95.9 95.9 93.9 83.7 67.3 51.0 |
| | |
| | |
|5000 U A | 100.0 98.0 98.0 98.0 98.0 92.0 92.0 82.0 74.0 62.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 500 U A/D 5000 U A/D 5000 U A |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.0% 64.0% 51.0% 62.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.631N P=0.174N P=1.000 P=0.417N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 639.1 655.9 601.3 584.6 |
|NATURAL DEATHS (C) | (17.8) (15.3) (30.9) (31.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 684.1 702.7 653.1 674.1 |
|(STANDARD ERROR) | (10.9) ( 7.4) (21.8) (15.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
INTERFERON A/INTERFERON AD
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
500 U A/D = 2
5000 U A/D = 3
5000 U A = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 3 4
|
| 1 3 1 2 44
| 1 2 12 344
95 +
| 12 3 24 31
| 224 1 1
| 33
90 + 22 33
|
| 1 1
| 224343 11
P 85 +
E | 22 4 4
R | 22 4 1 1
C |
E 80 + 22 4 4
N |
T | 3 3 4 4
| 2 2 1 1
S 75 + 33
U | 2 23 3 1 1
R | 22 4 114
V | 3 3
I 70 + 2 2 33 11
V |
A | 2 2 443
L | 4 4
65 +
| 2 2 1133
| 1144
|
60 + 22 114 4
| 3 3
| 2 11 23
| 1 12
55 +
| 11
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.
INTERFERON A/INTERFERON AD
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
500 U A/D = 2
5000 U A/D = 3
5000 U A = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 3 4 1 2
|
| 3 4 3 1 1 4 2 2
| 3 1 4 4 3 1 2 2
95 +
| 4 4 3 1 1 2 2
| 4 1 1 22
|
90 + 3 3 2 2
|
| 33 1 122
| 4 43 3 11
P 85 +
E | 4 43 3 2 2
R | 4 4 11
C | 33
E 80 + 3 3
N |
T | 4 4 1 1 22
| 44 22
S 75 +
U | 4 3 3114 22
R | 4 4
V |
I 70 + 2 2
V |
A | 33 44
L | 11 22
65 +
| 33 442 2
| 11 4 4
| 33
60 + 11
|
| 331 1
|
55 + 3 3
| 11
| 11
| 3 3
50 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.