TDMS Study 89006-02 Pathology Tables
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 30516-871
Lock Date: 11/01/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 6 5 9
Moribund Sacrifice 7 8 11 12
Dosing Accident 3 2 2 4
Accidently Killed 2
Survivors
Terminal Sacrifice 33 32 32 24
Missing 1
Animals Examined Microscopically 50 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (48)
Inflammation, Chronic 1 (2%)
Perforation 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Intestine Large, Colon (50) (48) (50) (49)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (50) (50) (50) (49)
Parasite Metazoan 1 (2%)
Intestine Large, Cecum (50) (49) (50) (48)
Edema 1 (2%) 2 (4%) 1 (2%)
Parasite Metazoan 1 (2%) 2 (4%)
Intestine Small, Duodenum (48) (49) (48) (48)
Erosion 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (50) (49) (49) (49)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (49) (49) (46) (47)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Liver (50) (50) (50) (49)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%) 3 (6%)
Clear Cell Focus 2 (4%)
Eosinophilic Focus 5 (10%) 1 (2%) 5 (10%) 3 (6%)
Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 4 (8%) 4 (8%)
Inflammation, Chronic 6 (12%) 6 (12%) 5 (10%) 7 (14%)
Mixed Cell Focus 2 (4%) 1 (2%) 1 (2%)
Necrosis, Focal 4 (8%) 6 (12%) 8 (16%)
Pigmentation, Focal 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Necrosis 1 (2%)
Centrilobular, Necrosis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Karyomegaly 1 (2%) 1 (2%)
Hepatocyte, Mixed Cell Focus 1 (2%)
Mesentery (10) (11) (9) (6)
Fat, Necrosis 8 (80%) 9 (82%) 7 (78%) 3 (50%)
Pancreas (50) (50) (50) (49)
Cyst 3 (6%) 1 (2%)
Acinus, Atrophy, Diffuse 3 (6%)
Salivary Glands (50) (49) (49) (48)
Inflammation, Chronic 2 (4%) 5 (10%) 2 (4%) 3 (6%)
Stomach, Forestomach (50) (50) (50) (49)
Edema 1 (2%)
Epithelium, Hyperplasia 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (50) (49)
Edema 2 (4%) 1 (2%)
Erosion 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (49)
Hypertrophy 1 (2%)
Inflammation, Chronic 1 (2%)
Heart (50) (50) (50) (49)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Mineralization 3 (6%)
Thrombosis 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (49)
Accessory Adrenal Cortical Nodule 7 (14%) 5 (10%) 6 (12%) 5 (10%)
Hyperplasia, Focal 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Hypertrophy, Focal 2 (4%)
Capsule, Hyperplasia, Focal 2 (4%) 1 (2%) 2 (4%)
Adrenal Medulla (49) (49) (49) (48)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Parathyroid Gland (45) (43) (46) (44)
Cyst 3 (7%) 1 (2%)
Pituitary Gland (50) (47) (48) (47)
Pars Distalis, Angiectasis 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 3 (6%) 9 (19%) 5 (10%) 4 (9%)
Thyroid Gland (50) (50) (50) (49)
Degeneration, Cystic, Focal 12 (24%) 15 (30%) 13 (26%) 9 (18%)
Follicle, Cyst 8 (16%) 4 (8%) 7 (14%) 9 (18%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hyperplasia 27 (54%) 16 (32%) 22 (44%) 13 (27%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (49) (49) (49)
Angiectasis 5 (10%) 10 (20%) 7 (14%) 6 (12%)
Cyst 9 (18%) 6 (12%) 13 (27%) 7 (14%)
Hyperplasia, Tubular 1 (2%)
Uterus (50) (50) (50) (49)
Angiectasis 1 (2%) 1 (2%) 2 (4%)
Hydrometra 14 (28%) 17 (34%) 19 (38%) 25 (51%)
Inflammation, Suppurative 2 (4%) 2 (4%) 2 (4%) 3 (6%)
Endometrium, Hyperplasia, Cystic 35 (70%) 41 (82%) 36 (72%) 31 (63%)
Vagina (49) (44) (48) (48)
Epithelium, Hyperplasia 4 (9%) 6 (13%) 11 (23%)
Epithelium, Hyperplasia, Atypical 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Hyperplasia 10 (20%) 14 (28%) 16 (32%) 14 (29%)
Myelofibrosis 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Lymph Node (4) (8) (10) (10)
Iliac, Hemorrhage 1 (10%)
Iliac, Hyperplasia, Lymphoid 2 (20%)
Inguinal, Hyperplasia, Lymphoid 1 (10%) 1 (10%)
Mediastinal, Hematopoietic Cell Proliferation 1 (10%)
Mediastinal, Hyperplasia, Lymphoid 1 (25%) 1 (10%) 1 (10%)
Renal, Hemorrhage 1 (10%)
Renal, Hyperplasia, Lymphoid 1 (10%)
Lymph Node, Mandibular (49) (45) (46) (48)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 2 (4%) 5 (11%) 4 (9%) 2 (4%)
Pigmentation 7 (14%) 8 (18%) 12 (26%) 14 (29%)
Lymph Node, Mesenteric (50) (47) (49) (49)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%) 3 (6%)
Hemorrhage 5 (10%) 5 (11%) 2 (4%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 6 (13%) 8 (16%) 2 (4%)
Spleen (50) (50) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 25 (50%) 28 (56%) 26 (52%) 30 (61%)
Hyperplasia, Lymphoid 6 (12%) 17 (34%) 10 (20%) 3 (6%)
Pigmentation 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Thymus (47) (46) (46) (45)
Atrophy 1 (2%) 3 (7%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (49)
Hyperplasia 5 (10%) 7 (14%) 2 (4%)
Skin (49) (50) (50) (49)
Ulcer 1 (2%)
Epidermis, Hyperplasia, Focal 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 3 (6%) 1 (2%)
Subcutaneous Tissue, Hemorrhage, Focal 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (49)
Hyperostosis 40 (82%) 39 (78%) 41 (82%) 34 (69%)
Femur, Osteopetrosis 1 (2%) 3 (6%)
Skeletal Muscle (50) (50) (50) (49)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Atrophy, Focal 4 (8%) 1 (2%) 3 (6%) 1 (2%)
Developmental Malformation 1 (2%)
Hydrocephalus 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Peripheral Nerve (2) (1) (6) (3)
Atrophy 1 (100%) 1 (17%) 1 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Hemorrhage 5 (10%) 2 (4%) 2 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 2 (4%) 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Nose (50) (50) (50) (49)
Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Congestion 1 (2%)
Metaplasia, Focal, Osseous 2 (4%) 2 (4%) 1 (2%)
Nephropathy 36 (72%) 34 (68%) 30 (60%) 30 (61%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Dilatation 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Hyaline Droplet 1 (2%)
Renal Tubule, Necrosis 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 13 14 5 9
Natural Death 1 7 4 6
Dosing Accident 2 2
Accidently Killed 1
Survivors
Terminal Sacrifice 36 27 38 35
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Perforation 2 (4%) 1 (2%)
Gallbladder (50) (47) (50) (46)
Inflammation, Chronic 1 (2%)
Intestine Large, Colon (50) (50) (50) (50)
Edema 2 (4%)
Parasite Metazoan 1 (2%)
Intestine Large, Cecum (50) (50) (50) (49)
Edema 1 (2%) 2 (4%) 1 (2%)
Parasite Metazoan 3 (6%) 7 (14%) 3 (6%) 5 (10%)
Intestine Small, Ileum (50) (48) (49) (50)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%) 1 (2%)
Basophilic Focus 4 (8%) 1 (2%) 2 (4%) 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Eosinophilic Focus 2 (4%) 1 (2%) 6 (12%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Inflammation, Chronic 39 (78%) 38 (76%) 38 (76%) 44 (88%)
Metaplasia, Osseous 2 (4%) 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%) 2 (4%) 1 (2%)
Necrosis, Focal 1 (2%) 7 (14%) 4 (8%)
Pigmentation, Focal 2 (4%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 3 (6%) 2 (4%) 1 (2%)
Bile Duct, Hyperplasia 26 (52%) 26 (52%) 26 (52%) 23 (46%)
Hepatocyte, Karyomegaly 33 (66%) 31 (62%) 35 (70%) 40 (80%)
Mesentery (1) (2) (1)
Fat, Necrosis 1 (100%) 1 (100%)
Pancreas (50) (50) (50) (50)
Cyst 1 (2%) 2 (4%)
Acinus, Atrophy, Diffuse 2 (4%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (50) (50) (50) (50)
Inflammation, Chronic 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 2 (4%) 2 (4%) 3 (6%)
Stomach, Glandular (50) (50) (50) (50)
Edema 2 (4%)
Erosion 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Hypertrophy 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 2 (4%)
Heart (50) (50) (50) (50)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 5 (10%) 1 (2%)
Mineralization 2 (4%) 1 (2%)
Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 7 (14%) 6 (12%) 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 9 (18%) 7 (14%) 10 (20%) 12 (24%)
Hyperplasia, Focal 7 (14%) 3 (6%) 8 (16%) 16 (32%)
Hypertrophy, Diffuse 1 (2%)
Hypertrophy, Focal 11 (22%) 5 (10%) 14 (28%) 13 (26%)
Capsule, Hyperplasia, Focal 4 (8%) 2 (4%) 3 (6%) 4 (8%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 4 (8%) 4 (8%) 5 (10%) 7 (14%)
Parathyroid Gland (48) (47) (48) (47)
Cyst 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (48) (43) (48) (47)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Thyroid Gland (50) (50) (50) (49)
Degeneration, Cystic, Focal 12 (24%) 14 (28%) 11 (22%) 14 (29%)
Follicle, Cyst 3 (6%) 4 (8%) 7 (14%) 5 (10%)
Follicular Cell, Hyperplasia 12 (24%) 15 (30%) 19 (38%) 10 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 2 (4%)
Preputial Gland (48) (48) (50) (50)
Cyst 10 (21%) 7 (15%) 4 (8%) 4 (8%)
Inflammation, Chronic 7 (15%) 13 (27%) 6 (12%) 4 (8%)
Testes (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 3 (6%) 2 (4%)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 14 (28%) 23 (46%) 16 (32%) 21 (42%)
Lymph Node (5) (8) (5) (5)
Bronchial, Hyperplasia, Lymphoid 1 (20%) 1 (20%)
Mediastinal, Hemorrhage 1 (13%)
Mediastinal, Hyperplasia, Lymphoid 1 (20%) 1 (20%)
Pancreatic, Hyperplasia, Lymphoid 1 (20%)
Renal, Hemorrhage 1 (13%)
Lymph Node, Mandibular (46) (47) (49) (46)
Hyperplasia, Lymphoid 2 (4%) 4 (9%) 2 (4%) 2 (4%)
Pigmentation 4 (9%) 10 (21%) 13 (27%) 8 (17%)
Lymph Node, Mesenteric (50) (48) (50) (47)
Hematopoietic Cell Proliferation 7 (14%) 6 (13%) 1 (2%) 7 (15%)
Hemorrhage 19 (38%) 15 (31%) 17 (34%) 18 (38%)
Hyperplasia, Lymphoid 6 (12%) 5 (10%) 12 (24%) 8 (17%)
Spleen (50) (49) (49) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 20 (40%) 29 (59%) 17 (35%) 23 (46%)
Hyperplasia, Lymphoid 6 (12%) 4 (8%) 4 (8%) 1 (2%)
Necrosis, Focal 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Thymus (45) (40) (42) (43)
Atrophy 1 (2%) 3 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Mineralization 1 (2%)
Ulcer 2 (4%) 2 (4%)
Subcutaneous Tissue, Edema 4 (8%) 4 (8%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 42 (84%) 31 (62%) 39 (78%) 39 (78%)
Femur, Osteopetrosis 1 (2%)
Skeletal Muscle (50) (50) (50) (50)
Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Atrophy, Focal 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%) 5 (10%) 1 (2%)
Infiltration Cellular, Histiocyte 6 (12%) 6 (12%) 8 (16%) 4 (8%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%) 5 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Atrophy 1 (100%) 1 (100%)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 89006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 08:14:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120MG/KG
CONTROL 500 U 500 U 500 U
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Focal, Osseous 2 (4%) 1 (2%)
Nephropathy 47 (94%) 46 (92%) 44 (88%) 49 (98%)
Pelvis, Dilatation 1 (2%) 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%)
Renal Tubule, Hyaline Droplet 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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