TDMS Study 89006-02 Pathology Tables
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 30516-871
Lock Date: 11/01/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 2| 6| 3| 6| 2| 0| 3| 2| 3| 2| 1| 0| 1| 1| 3| 3| 8| 3| 2| 3| 2| 2|
| 0| 5| 0| 9| 8| 0| 7| 9| 5| 0| 9| 0| 9| 0| 7| 0| 7| 0| 0| 8| 0| 9| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | X |
__________________________________________________________________________|
Gallbladder | + + + + A + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | 3 3 |
Inflammation, Chronic | 2 |
Mixed Cell Focus | 2 |
Necrosis, Focal | 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 3 4 4 4 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + I + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 3 |
Hyperplasia, Focal | 2 |
Capsule, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 2| 6| 3| 6| 2| 0| 3| 2| 3| 2| 1| 0| 1| 1| 3| 3| 8| 3| 2| 3| 2| 2|
| 0| 5| 0| 9| 8| 0| 7| 9| 5| 0| 9| 0| 9| 0| 7| 0| 7| 0| 0| 8| 0| 9| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 2 1 2 2 3 1 2 1 |
Follicle, Cyst | 3 3 4 3 |
Follicular Cell, Hyperplasia | 2 3 1 1 3 1 3 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | 4 4 4 3 4 4 2 |
Inflammation, Suppurative | 4 |
Endometrium, Hyperplasia, Cystic | 4 3 2 3 3 3 3 3 3 4 4 2 3 2 3 3|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 1 2 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 1 1 2 2 3 4 3 2 3 3 2 |
Hyperplasia, Lymphoid | 2 2 3 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + I + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 2| 6| 3| 6| 2| 0| 3| 2| 3| 2| 1| 0| 1| 1| 3| 3| 8| 3| 2| 3| 2| 2|
| 0| 5| 0| 9| 8| 0| 7| 9| 5| 0| 9| 0| 9| 0| 7| 0| 7| 0| 0| 8| 0| 9| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + I + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 1 1 3 3 4 4 3 3 3 3 2 2 4 3 2 4 4 4|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 2 |
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Thrombosis | 3 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 0| 7| 7| |
DAY ON TEST | 7| 0| 3| 2| 2| 2| 2| 3| 4| 2| 0| 2| 2| 3| 2| 9| 2| 9| 3| 2| 2| 3| 2| 2| 3| |
| 5| 5| 0| 9| 9| 9| 9| 0| 9| 9| 3| 9| 9| 0| 9| 3| 9| 0| 0| 9| 9| 0| 6| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | X | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Erosion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | 2 4 2 3| 5 2.6|
Hematopoietic Cell Proliferation | 2 | 3 2.7|
Inflammation, Chronic | 2 1 1 2 1| 6 1.5|
Mixed Cell Focus | 4 | 2 3.0|
Necrosis, Focal | 3 3 | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Fat, Necrosis | 4 4 | 8 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 1 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 4.0|
Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 2 3 2 2 | 7 2.0|
Hyperplasia, Focal | | 1 2.0|
Capsule, Hyperplasia, Focal | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 0| 7| 7| |
DAY ON TEST | 7| 0| 3| 2| 2| 2| 2| 3| 4| 2| 0| 2| 2| 3| 2| 9| 2| 9| 3| 2| 2| 3| 2| 2| 3| |
| 5| 5| 0| 9| 9| 9| 9| 0| 9| 9| 3| 9| 9| 0| 9| 3| 9| 0| 0| 9| 9| 0| 6| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + M + + + + + + + + + M + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia, Focal | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 1 2 | 12 1.7|
Follicle, Cyst | 3 3 3 3| 8 3.1|
Follicular Cell, Hyperplasia | 3 1 1 1 3 3 3 3 1 2 3 1 3 2 3 1 1| 27 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | I + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 2 | 5 2.0|
Cyst | 3 3 3 3 3 | 9 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hydrometra | 3 3 1 3 2 4 3 | 14 3.1|
Inflammation, Suppurative | 1 | 2 2.5|
Endometrium, Hyperplasia, Cystic | 2 2 3 4 3 3 3 3 3 3 3 3 3 3 3 3 2 4 2| 35 2.9|
__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 3 3 4 | 10 2.8|
Myelofibrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Pigmentation | 2 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 4 3 | 5 2.8|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 0| 7| 7| |
DAY ON TEST | 7| 0| 3| 2| 2| 2| 2| 3| 4| 2| 0| 2| 2| 3| 2| 9| 2| 9| 3| 2| 2| 3| 2| 2| 3| |
| 5| 5| 0| 9| 9| 9| 9| 0| 9| 9| 3| 9| 9| 0| 9| 3| 9| 0| 0| 9| 9| 0| 6| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 4 2 3 1 2 1 2 4 2 | 25 2.4|
Hyperplasia, Lymphoid | 3 2 3| 6 2.5|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperostosis | 4 3 3 1 3 3 4 4 4 3 3 3 2 3 3 3 3 3 3 2 3| 40 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 3 2 | 4 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 5 1.6|
Infiltration Cellular, Histiocyte | | 2 2.0|
Inflammation, Chronic | 2 3 2| 3 2.3|
Inflammation, Suppurative | 3 | 2 3.0|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 3 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 0| 7| 7| |
DAY ON TEST | 7| 0| 3| 2| 2| 2| 2| 3| 4| 2| 0| 2| 2| 3| 2| 9| 2| 9| 3| 2| 2| 3| 2| 2| 3| |
| 5| 5| 0| 9| 9| 9| 9| 0| 9| 9| 3| 9| 9| 0| 9| 3| 9| 0| 0| 9| 9| 0| 6| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 1 2 1 1 1 2 1 1 2 1 1 1 2 1 1| 36 1.1|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 4| 6| 0| 7| 7| 0| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 3| 1| 3| 2| 3| 4| 3| 5| 3| 0| 2| 3| 0| 8| 2| 2| 2|
| 0| 9| 0| 8| 9| 9| 0| 9| 0| 0| 4| 6| 0| 1| 1| 7| 0| 2| 4| 0| 3| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | X |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + I I + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + I + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 3 |
Inflammation, Chronic | 1 1 3 |
Pigmentation, Focal | 2 |
Bile Duct, Hyperplasia | 3 |
Centrilobular, Necrosis, Focal | 3 |
Hepatocyte, Karyomegaly | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Fat, Necrosis | 4 2 3 2 3 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 3 3 |
Hyperplasia, Focal | 1 |
Capsule, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 4| 6| 0| 7| 7| 0| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 3| 1| 3| 2| 3| 4| 3| 5| 3| 0| 2| 3| 0| 8| 2| 2| 2|
| 0| 9| 0| 8| 9| 9| 0| 9| 0| 0| 4| 6| 0| 1| 1| 7| 0| 2| 4| 0| 3| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M M + M M + + + M M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + M + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 2 2 2 2 2 3|
Follicle, Cyst | 3 3 |
Follicular Cell, Hyperplasia | 2 2 2 1 3 3 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + I + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | 3 2 4 2 3 3 4 |
Cyst | 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 4 4 3 4 |
Inflammation, Suppurative | 1 |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 4 3 3 3 4 3 3 2 2 3 3 4 3 2 3 4 2|
__________________________________________________________________________|
Vagina | + + + + + + + I + + + M + + + M + + M + + + + + +|
Epithelium, Hyperplasia | 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + I + + + + + + + + M|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 3 2 |
Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + I M + +|
Hematopoietic Cell Proliferation | 2 3 4|
Hemorrhage | 2 2 2 2 3 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 2 4 3 2 4 1 1 1 3 3 3 3 2 3|
Hyperplasia, Lymphoid | 2 3 3 2 3 1 2 2 3 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 4| 6| 0| 7| 7| 0| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 3| 1| 3| 2| 3| 4| 3| 5| 3| 0| 2| 3| 0| 8| 2| 2| 2|
| 0| 9| 0| 8| 9| 9| 0| 9| 0| 0| 4| 6| 0| 1| 1| 7| 0| 2| 4| 0| 3| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia, Focal | |
Subcutaneous Tissue, Edema | 3 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 4 2 4 3 4 4 3 4 3 3 3 3 1 2 4 3 2 2|
Femur, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | |
Atrophy | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | 1 |
Nephropathy | 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 |
Renal Tubule, Hyaline Droplet | |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 4|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 4| 6| 0| 7| 7| 0| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 3| 1| 3| 2| 3| 4| 3| 5| 3| 0| 2| 3| 0| 8| 2| 2| 2|
| 0| 9| 0| 8| 9| 9| 0| 9| 0| 0| 4| 6| 0| 1| 1| 7| 0| 2| 4| 0| 3| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 4| 7| 5| 5| |
DAY ON TEST | 3| 0| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 6| 3| 2| 2| 2| 3| 3| 6| 3| 2| 4| |
| 0| 2| 7| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 8| 1| 0| 9| 9| 9| 0| 0| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | X | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Eosinophilic Focus | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 3 1.7|
Inflammation, Chronic | 1 1 1 | 6 1.3|
Pigmentation, Focal | | 1 2.0|
Bile Duct, Hyperplasia | | 1 3.0|
Centrilobular, Necrosis, Focal | | 1 3.0|
Hepatocyte, Karyomegaly | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 11 |
Fat, Necrosis | 3 2 3 | 9 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 1.5|
Mineralization | 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 4| 7| 5| 5| |
DAY ON TEST | 3| 0| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 6| 3| 2| 2| 2| 3| 3| 6| 3| 2| 4| |
| 0| 2| 7| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 8| 1| 0| 9| 9| 9| 0| 0| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 2 | 2 1.5|
Capsule, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + I + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
Pars Distalis, Angiectasis | 3 2 | 3 2.3|
Pars Distalis, Hyperplasia, Focal | 1 3 1 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 2 2 1 3 2 1 2| 15 1.9|
Follicle, Cyst | 3 3 | 4 3.0|
Follicular Cell, Hyperplasia | 2 2 2 2 1 1 1 2 | 16 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 2| 10 2.7|
Cyst | 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 2 4 4 4 3 4 3 3 4 4 3 | 17 3.5|
Inflammation, Suppurative | 2 | 2 1.5|
Endometrium, Hyperplasia, Cystic | 3 4 2 3 3 4 2 3 3 4 4 3 3 3 3 4 2 4 3 2| 41 3.0|
__________________________________________________________________________|____________|
Vagina | + M + + + + + + + + + + + + + + + + + + + I + + +| 44 |
Epithelium, Hyperplasia | 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 4 2 4 4 4 | 14 2.6|
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + M + + + + + + + + + + + + I + + + + + +| 45 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 2 | 2 1.5|
Hyperplasia, Lymphoid | 2 2 | 5 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 4| 7| 5| 5| |
DAY ON TEST | 3| 0| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 6| 3| 2| 2| 2| 3| 3| 6| 3| 2| 4| |
| 0| 2| 7| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 8| 1| 0| 9| 9| 9| 0| 0| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 2 2 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + I + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | | 3 3.0|
Hemorrhage | | 5 2.2|
Hyperplasia, Lymphoid | 3 3 2 3 | 6 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 3 2 2 2 4 4 3 4 4 4 | 28 2.6|
Hyperplasia, Lymphoid | 2 2 3 3 2 2 2 2 | 17 2.3|
Pigmentation | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + I + + + + + + + + + + M + + + + + + + + + + M +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia, Focal | 1 | 1 1.0|
Subcutaneous Tissue, Edema | 2 | 3 2.7|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 4 4 4 3 4 4 2 4 3 3 2 3 2 3 4 4 2 4 3 | 39 3.2|
Femur, Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 3.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.5|
Infiltration Cellular, Histiocyte | 1 | 2 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 4| 7| 5| 5| |
DAY ON TEST | 3| 0| 6| 3| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 6| 3| 2| 2| 2| 3| 3| 6| 3| 2| 4| |
| 0| 2| 7| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 8| 1| 0| 9| 9| 9| 0| 0| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Focal, Osseous | 2 | 2 1.5|
Nephropathy | 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 | 34 1.2|
Renal Tubule, Hyaline Droplet | 1 | 1 1.0|
Renal Tubule, Necrosis | 1 | 1 1.0|
Renal Tubule, Pigmentation | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 2| 3| 1| 4| 3| 3| 2| 2| 3| 2| 2| 2| 3| 9| 5| 2| 3| 2| 2| 3| 3| 2| 1|
| 0| 4| 9| 6| 4| 5| 0| 0| 9| 9| 0| 9| 9| 9| 0| 8| 6| 9| 0| 9| 9| 0| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Eosinophilic Focus | 2 2 1 1 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 1 |
Mixed Cell Focus | 2 |
Necrosis, Focal | 1 1 |
Vacuolization Cytoplasmic | |
Hepatocyte, Karyomegaly | 2 |
Hepatocyte, Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 2 3 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 2 2 3 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 2| 3| 1| 4| 3| 3| 2| 2| 3| 2| 2| 2| 3| 9| 5| 2| 3| 2| 2| 3| 3| 2| 1|
| 0| 4| 9| 6| 4| 5| 0| 0| 9| 9| 0| 9| 9| 9| 0| 8| 6| 9| 0| 9| 9| 0| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M M + M + + + M +|
Cyst | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia, Focal | 1 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 2 1 1 |
Follicle, Cyst | 3 3 3 3 3 |
Follicular Cell, Hyperplasia | 2 3 2 2 2 1 2 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | I + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 |
Cyst | 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 4 4 4 3 4 4 4 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 4 3 3 3 2 3 3 3 2 3 4 3 2 2 3 3 3 2 4|
__________________________________________________________________________|
Vagina | + + + + + + + + + + M + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Atypical | 2 |
Epithelium, Hyperplasia | 1 1 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 4 3|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Iliac, Hemorrhage | 3 |
Iliac, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | 4 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + I + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 2| 3| 1| 4| 3| 3| 2| 2| 3| 2| 2| 2| 3| 9| 5| 2| 3| 2| 2| 3| 3| 2| 1|
| 0| 4| 9| 6| 4| 5| 0| 0| 9| 9| 0| 9| 9| 9| 0| 8| 6| 9| 0| 9| 9| 0| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + I + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 3 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 3 2 3 2 2 4 3 2 2 4 |
Hyperplasia, Lymphoid | 2 2 3 3 2 3 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + M + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 2 4 3 3 3 3 2 3 2 3 3 4 4 3 4 4 2 3 3 3|
Femur, Osteopetrosis | 3 2 3 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 |
Hydrocephalus | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + + |
Atrophy | |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 1| 2| 3| 1| 4| 3| 3| 2| 2| 3| 2| 2| 2| 3| 9| 5| 2| 3| 2| 2| 3| 3| 2| 1|
| 0| 4| 9| 6| 4| 5| 0| 0| 9| 9| 0| 9| 9| 9| 0| 8| 6| 9| 0| 9| 9| 0| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | 1 2 |
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 0| 6| 7| 7| 5| 7| 7| 7| 6| 7| 0| |
DAY ON TEST | 9| 3| 2| 0| 3| 2| 2| 8| 3| 2| 6| 3| 2| 8| 2| 4| 3| 2| 9| 3| 2| 2| 1| 3| 1| |
| 7| 0| 9| 7| 0| 9| 9| 9| 0| 9| 0| 0| 9| 2| 0| 7| 0| 9| 4| 0| 9| 9| 4| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | X| 1 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M I + + + + + + + + M + + + + + + + + + + + + +| 46 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 2.0|
Eosinophilic Focus | 2 | 5 1.6|
Hematopoietic Cell Proliferation | 3 3 2 | 4 2.5|
Inflammation, Chronic | 1 2 1 | 5 1.4|
Mixed Cell Focus | | 1 2.0|
Necrosis, Focal | 1 3 2 1 | 6 1.5|
Vacuolization Cytoplasmic | 3| 1 3.0|
Hepatocyte, Karyomegaly | | 1 2.0|
Hepatocyte, Mixed Cell Focus | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Fat, Necrosis | 2 | 7 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 1 | 6 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 0| 6| 7| 7| 5| 7| 7| 7| 6| 7| 0| |
DAY ON TEST | 9| 3| 2| 0| 3| 2| 2| 8| 3| 2| 6| 3| 2| 8| 2| 4| 3| 2| 9| 3| 2| 2| 1| 3| 1| |
| 7| 0| 9| 7| 0| 9| 9| 9| 0| 9| 0| 0| 9| 2| 0| 7| 0| 9| 4| 0| 9| 9| 4| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Cyst | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 3 | 5 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 1 2 1 3 2 1 2 | 13 1.5|
Follicle, Cyst | 3 3 | 7 3.0|
Follicular Cell, Hyperplasia | 1 2 1 3 1 2 3 1 3 3 1 1 | 22 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 4 | 7 2.3|
Cyst | 3 3 3 3 3 4 | 13 3.1|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hydrometra | 4 2 3 4 3 3 3 4 3 2 4 | 19 3.4|
Inflammation, Suppurative | 3 1 | 2 2.0|
Endometrium, Hyperplasia, Cystic | 2 4 2 4 3 3 3 4 3 2 4 3 2 3 4 2 4 | 36 3.0|
__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + I| 48 |
Epithelium, Hyperplasia, Atypical | 4 | 2 3.0|
Epithelium, Hyperplasia | 2 3 | 6 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 2 4 3 1 3 2 2 3 | 16 2.9|
Myelofibrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
Iliac, Hemorrhage | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 0| 6| 7| 7| 5| 7| 7| 7| 6| 7| 0| |
DAY ON TEST | 9| 3| 2| 0| 3| 2| 2| 8| 3| 2| 6| 3| 2| 8| 2| 4| 3| 2| 9| 3| 2| 2| 1| 3| 1| |
| 7| 0| 9| 7| 0| 9| 9| 9| 0| 9| 0| 0| 9| 2| 0| 7| 0| 9| 4| 0| 9| 9| 4| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hemorrhage | | 1 4.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + I + + + + +| 46 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 3 2 | 4 2.8|
Pigmentation | 2 3 2 2 2 2 2 2 | 12 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | 3 4 | 2 3.5|
Hyperplasia, Lymphoid | 3 4 2 | 8 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 2 3 3 4 4 4 2 2 2 4 3 2 1 | 26 2.7|
Hyperplasia, Lymphoid | 3 2 | 10 2.4|
Pigmentation | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + M + + + + + + + + + +| 46 |
Atrophy | 3 3 3| 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 4.0|
Subcutaneous Tissue, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 3 3 2 4 4 3 1 4 3 3 4 4 3 3 3 3 4 3 4 | 41 3.1|
Femur, Osteopetrosis | | 3 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 4 | 3 3.7|
Hydrocephalus | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 0| 6| 7| 7| 5| 7| 7| 7| 6| 7| 0| |
DAY ON TEST | 9| 3| 2| 0| 3| 2| 2| 8| 3| 2| 6| 3| 2| 8| 2| 4| 3| 2| 9| 3| 2| 2| 1| 3| 1| |
| 7| 0| 9| 7| 0| 9| 9| 9| 0| 9| 0| 0| 9| 2| 0| 7| 0| 9| 4| 0| 9| 9| 4| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 6 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 4 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Focal, Osseous | | 2 1.5|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 | 30 1.1|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 7| 0| 6| 7| 7| 6| 7| 6| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 9| 1| 2| 3| 3| 2| 0| 2| 2| 7| 3| 6| 6| 2| 7| 3| 2| 9| 3| 2| 3| 3| 2|
| 1| 9| 9| 7| 9| 1| 0| 5| 4| 9| 9| 3| 0| 9| 2| 5| 7| 0| 9| 1| 0| 9| 1| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Perforation | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 4 |
Clear Cell Focus | 4 |
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | 1 3 |
Inflammation, Chronic | 3 1 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 3 1 3|
Pigmentation, Focal | |
Vacuolization Cytoplasmic | 3 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Acinus, Atrophy, Diffuse | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | |
Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 7| 0| 6| 7| 7| 6| 7| 6| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 9| 1| 2| 3| 3| 2| 0| 2| 2| 7| 3| 6| 6| 2| 7| 3| 2| 9| 3| 2| 3| 3| 2|
| 1| 9| 9| 7| 9| 1| 0| 5| 4| 9| 9| 3| 0| 9| 2| 5| 7| 0| 9| 1| 0| 9| 1| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 1|
Capsule, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + M M + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 3 2 2 1 1 |
Follicle, Cyst | 3 3 3 3 3 |
Follicular Cell, Hyperplasia | 1 1 3 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 4 3 |
Cyst | 3 |
Hyperplasia, Tubular | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 4 4 3 4 4 3 3 3 4 3 4 4 |
Inflammation, Suppurative | 4 3 |
Endometrium, Hyperplasia, Cystic | 4 3 4 2 3 3 2 3 3 4 3 3 3 3 3 3|
__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Atypical | 4 |
Epithelium, Hyperplasia | 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 4 1 2 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Inguinal, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 7| 0| 6| 7| 7| 6| 7| 6| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 9| 1| 2| 3| 3| 2| 0| 2| 2| 7| 3| 6| 6| 2| 7| 3| 2| 9| 3| 2| 3| 3| 2|
| 1| 9| 9| 7| 9| 1| 0| 5| 4| 9| 9| 3| 0| 9| 2| 5| 7| 0| 9| 1| 0| 9| 1| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Pigmentation | 3 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 2 4 2 3 3 3 3 4 4 1 2|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + I + + + I + + + + + + + M + + + + +|
Atrophy | 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia, Focal | |
Subcutaneous Tissue, Hemorrhage, | |
Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 4 4 2 1 2 3 3 3 3 4 3 3 2 1|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 |
Developmental Malformation | |
Hydrocephalus | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
Atrophy | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 7| 0| 6| 7| 7| 6| 7| 6| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 9| 1| 2| 3| 3| 2| 0| 2| 2| 7| 3| 6| 6| 2| 7| 3| 2| 9| 3| 2| 3| 3| 2|
| 1| 9| 9| 7| 9| 1| 0| 5| 4| 9| 9| 3| 0| 9| 2| 5| 7| 0| 9| 1| 0| 9| 1| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Metaplasia, Focal, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 3 2|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 0| 7| 0| 7| 7| 4| 7| 6| 3| 7| 7| 7| 5| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 3| 3| 9| 7| 3| 3| 3| 9| 3| 2| 2| 1| 3| 3| 3| 3| 3| 0| 3| 0| |
| 4| 0| 5| 1| 0| 0| 0| 5| 6| 0| 1| 1| 7| 0| 2| 6| 0| 2| 0| 1| 0| 0| 3| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | | 1 3.0|
Perforation | X X | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + I + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + I + + + + + + + + + + + +| 48 |
Edema | | 1 2.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + I + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | 1 | 3 2.7|
Clear Cell Focus | 3 | 2 3.5|
Eosinophilic Focus | 2 2 | 3 2.3|
Hematopoietic Cell Proliferation | 1 2 | 4 1.8|
Inflammation, Chronic | 1 2 1 3 | 7 1.7|
Mixed Cell Focus | 2 | 1 2.0|
Necrosis, Focal | 1 4 3 1| 8 2.3|
Pigmentation, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic | 4 | 2 3.5|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Necrosis | 4 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Acinus, Atrophy, Diffuse | 2 4 4 | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 1 2.0|
Erosion | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 0| 7| 0| 7| 7| 4| 7| 6| 3| 7| 7| 7| 5| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 3| 3| 9| 7| 3| 3| 3| 9| 3| 2| 2| 1| 3| 3| 3| 3| 3| 0| 3| 0| |
| 4| 0| 5| 1| 0| 0| 0| 5| 6| 0| 1| 1| 7| 0| 2| 6| 0| 2| 0| 1| 0| 0| 3| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypertrophy | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 3 3 2 | 5 2.4|
Hyperplasia, Focal | 1 2 1 | 3 1.3|
Hypertrophy, Focal | 2 | 2 1.5|
Capsule, Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + M + +| 44 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia, Focal | 1 3 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic, Focal | 2 3 2 2 | 9 2.0|
Follicle, Cyst | 3 3 3 3 | 9 3.0|
Follicular Cell, Hyperplasia | 2 1 2 1 2 1 1| 13 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 | 6 2.5|
Cyst | 3 3 3 3 3 3| 7 3.0|
Hyperplasia, Tubular | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 2 | 2 2.5|
Hydrometra | 4 4 4 3 4 4 2 3 4 3 4 3 | 25 3.5|
Inflammation, Suppurative | 2 | 3 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 2 3 3 2 3 3 2 3 3 3 3 3 3| 31 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 0| 7| 0| 7| 7| 4| 7| 6| 3| 7| 7| 7| 5| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 3| 3| 9| 7| 3| 3| 3| 9| 3| 2| 2| 1| 3| 3| 3| 3| 3| 0| 3| 0| |
| 4| 0| 5| 1| 0| 0| 0| 5| 6| 0| 1| 1| 7| 0| 2| 6| 0| 2| 0| 1| 0| 0| 3| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Epithelium, Hyperplasia, Atypical | | 1 4.0|
Epithelium, Hyperplasia | 1 1 1 1 1 2 | 11 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 4 3 3 3 3 3 2 2| 14 2.8|
Myelofibrosis | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + +| 10 |
Inguinal, Hyperplasia, Lymphoid | 3| 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Pigmentation | 2 2 2 2 3 2 2 2 2| 14 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 | 3 2.3|
Hemorrhage | 1 | 2 1.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 3 3 2 3 4 1 1 2 2 3 3 3 3 4 2 2| 30 2.7|
Hyperplasia, Lymphoid | 3 3 | 3 2.7|
Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
Atrophy | 4 | 2 3.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epidermis, Hyperplasia, Focal | 2 | 1 2.0|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperostosis | 3 3 3 3 1 3 3 2 3 3 2 4 2 3 3 3 3 3 4| 34 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 0| 7| 0| 7| 7| 4| 7| 6| 3| 7| 7| 7| 5| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 3| 3| 9| 7| 3| 3| 3| 9| 3| 2| 2| 1| 3| 3| 3| 3| 3| 0| 3| 0| |
| 4| 0| 5| 1| 0| 0| 0| 5| 6| 0| 1| 1| 7| 0| 2| 6| 0| 2| 0| 1| 0| 0| 3| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Focal | | 1 4.0|
Developmental Malformation | X | 1 |
Hydrocephalus | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 3 4 | 3 3.7|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 2.0|
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 4 2 1 1 1 1 1| 30 1.3|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 1| 5| 3| 0| 3|
| 1| 6| 0| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 6| 8| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 2 1 |
Clear Cell Focus | X |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 3 3 3 2 3 2 3 3 2 2 3 3 3 3 4 3 3 2 2 2 3 |
Metaplasia, Osseous | |
Mixed Cell Focus | 3 |
Necrosis, Focal | 1 |
Pigmentation, Focal | 3 2 |
Vacuolization Cytoplasmic | 2 3|
Bile Duct, Hyperplasia | 3 2 2 1 4 2 2 3 4 3 2 4 3 3 |
Hepatocyte, Karyomegaly | 3 3 3 3 4 3 2 3 3 2 2 4 3 3 3 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Acinus, Atrophy, Diffuse | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 1| 5| 3| 0| 3|
| 1| 6| 0| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 6| 8| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 2 |
Cytoplasmic Alteration, Focal | 2 2 2 2 2|
Hyperplasia, Focal | 2 1 2 1|
Hypertrophy, Focal | 2 2 1 3 2 1 |
Capsule, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
Pars Distalis, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 2 1 2 1 |
Follicle, Cyst | 3 3 3 |
Follicular Cell, Hyperplasia | 3 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | 3 3 3 3 3 |
Inflammation, Chronic | 3 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 3 2 4 |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 4 2 |
Pigmentation | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 |
Hemorrhage | 4 4 3 3 1 2 1 1|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 1| 5| 3| 0| 3|
| 1| 6| 0| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 6| 8| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 4 2 1 3 2 2 2 1 |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + I + + + + + + + + + + M + + M + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 4 3 3 3 4 4 3 3 3 2 2 2 3 3 3 3 3 3 4|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 4 4 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Metaplasia, Focal, Osseous | 1 1 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 1| 5| 3| 0| 3|
| 1| 6| 0| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 6| 8| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 2 1 2 1 2 2 2 2 2 1 1 1 2 2 1 2 2 2 1 1 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 7| 1| 1| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 7| 1| 1| 1| 1| 1| 1| 5| 6| 8| 1| 4| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Basophilic Focus | 3 | 4 2.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | 2| 2 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Inflammation, Chronic | 2 3 2 2 3 2 3 3 3 3 3 2 3 3 3 2 3 3 | 39 2.7|
Metaplasia, Osseous | 2 2 | 2 2.0|
Mixed Cell Focus | | 1 3.0|
Necrosis, Focal | | 1 1.0|
Pigmentation, Focal | | 2 2.5|
Vacuolization Cytoplasmic | 3 | 3 2.7|
Bile Duct, Hyperplasia | 2 2 3 3 3 3 3 4 3 4 3 3 | 26 2.8|
Hepatocyte, Karyomegaly | 3 3 2 4 3 3 2 3 4 2 4 2 3 3 4 3 3 | 33 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Acinus, Atrophy, Diffuse | 4 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 7| 1| 1| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 7| 1| 1| 1| 1| 1| 1| 5| 6| 8| 1| 4| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 1 3 1 2 | 7 2.0|
Cytoplasmic Alteration, Focal | 1 2 1 2| 9 1.8|
Hyperplasia, Focal | 1 1 3| 7 1.6|
Hypertrophy, Focal | 1 2 2 2 2| 11 1.8|
Capsule, Hyperplasia, Focal | 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Pars Distalis, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 3 2 2 1 1 | 12 1.7|
Follicle, Cyst | | 3 3.0|
Follicular Cell, Hyperplasia | 3 3 1 2 1 3 3 1 1| 12 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + I + + + + + + + + + + + + + + +| 48 |
Cyst | 3 3 3 3 3 | 10 3.0|
Inflammation, Chronic | 3 4 4 | 7 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 7| 1| 1| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 7| 1| 1| 1| 1| 1| 1| 5| 6| 8| 1| 4| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 3 2 3 2 | 14 2.9|
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + M + + + + + + + M| 46 |
Hyperplasia, Lymphoid | | 2 3.0|
Pigmentation | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 | 7 2.1|
Hemorrhage | 3 3 2 2 2 2 3 1 2 3 1 | 19 2.3|
Hyperplasia, Lymphoid | 2 3 3 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 2 2 1 2 4 4 2 2 2 | 20 2.4|
Hyperplasia, Lymphoid | 3 2 2 2 | 6 2.2|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M M + + + + + + + + + + + + +| 45 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
Subcutaneous Tissue, Edema | 3 2 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 4 3 4 3 4 3 3 3 4 4 3 3 3 2 3 3 3 2 3 3| 42 3.1|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 3 3 2 3 | 6 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 7| 1| 1| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 7| 1| 1| 1| 1| 1| 1| 5| 6| 8| 1| 4| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Metaplasia, Focal, Osseous | | 2 1.0|
Nephropathy | 1 1 1 2 1 2 2 2 1 1 2 1 2 2 1 2 2 1 2 1 1 2 2 1| 47 1.5|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 1 3.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + + + + +| 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 0| 2| 0| 1| 6| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 1| 3| 1| 3| 3| 0| 3| 0| 9| 1| 3| 5| 4| 0| 3| 2| 7| 3| 3| 3| 3| 3| 3| 7| 3|
| 7| 1| 8| 1| 1| 5| 1| 3| 6| 5| 1| 8| 2| 8| 1| 3| 9| 1| 1| 1| 1| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | X X |
__________________________________________________________________________|
Gallbladder | + + + M + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3|
Basophilic Focus | 2 |
Clear Cell Focus | |
Eosinophilic Focus | |
Inflammation, Chronic | 3 3 3 3 3 2 3 3 3 3 4 3 1 3 3 3 1 4|
Metaplasia, Osseous | 2 |
Necrosis, Focal | 4 2 4 1 3 |
Vacuolization Cytoplasmic | 3 3 |
Bile Duct, Hyperplasia | 3 4 3 2 3 3 2 3 2 3 4 2 3 2 3 4|
Hepatocyte, Karyomegaly | 2 4 3 2 3 2 3 3 3 3 3 2 3 3|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | |
Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hemorrhage | 2 |
Inflammation, Chronic | 2 3 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 0| 2| 0| 1| 6| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 1| 3| 1| 3| 3| 0| 3| 0| 9| 1| 3| 5| 4| 0| 3| 2| 7| 3| 3| 3| 3| 3| 3| 7| 3|
| 7| 1| 8| 1| 1| 5| 1| 3| 6| 5| 1| 8| 2| 8| 1| 3| 9| 1| 1| 1| 1| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | 3 1 2 |
Cytoplasmic Alteration, Focal | 2 2 |
Hyperplasia, Focal | 1 |
Hypertrophy, Diffuse | 4 |
Hypertrophy, Focal | 1 1 1 |
Capsule, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + M + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 3 2 1 3 1 2 1|
Follicle, Cyst | 3 3 3|
Follicular Cell, Hyperplasia | 1 2 2 1 3 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 |
Inflammation, Chronic | 4 3 2 4 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 4 2 3 4 3 3 2 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Hemorrhage | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 2 2 |
Pigmentation | 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | 2 1 4 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 0| 2| 0| 1| 6| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 1| 3| 1| 3| 3| 0| 3| 0| 9| 1| 3| 5| 4| 0| 3| 2| 7| 3| 3| 3| 3| 3| 3| 7| 3|
| 7| 1| 8| 1| 1| 5| 1| 3| 6| 5| 1| 8| 2| 8| 1| 3| 9| 1| 1| 1| 1| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 1 2 4 3 4 1 3 4 3 2 4 3 2 2 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | M + + + M + + + M + + + M + + + + M + + + + + + +|
Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Subcutaneous Tissue, Edema | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 2 2 3 2 2 3 3 1 3 1 2 2|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 4 3 1 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 0| 2| 0| 1| 6| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 1| 3| 1| 3| 3| 0| 3| 0| 9| 1| 3| 5| 4| 0| 3| 2| 7| 3| 3| 3| 3| 3| 3| 7| 3|
| 7| 1| 8| 1| 1| 5| 1| 3| 6| 5| 1| 8| 2| 8| 1| 3| 9| 1| 1| 1| 1| 1| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Metaplasia, Focal, Osseous | |
Nephropathy | 2 2 1 1 4 2 1 1 2 1 1 2 3 1 2 1 1 1 1 2 1 2|
Pelvis, Dilatation | 1 |
Renal Tubule, Hyaline Droplet | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urethra | I + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 6| 7| 3| 5| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 7| 5| 5| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3| 2| 0| |
| 4| 1| 6| 4| 6| 0| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 2 2.0|
Parasite Metazoan | X X X X | 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + I + + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 3.5|
Basophilic Focus | | 1 2.0|
Clear Cell Focus | 2 | 1 2.0|
Eosinophilic Focus | 3 | 1 3.0|
Inflammation, Chronic | 3 3 3 2 2 3 3 2 3 3 4 3 3 3 3 3 2 2 3 2| 38 2.8|
Metaplasia, Osseous | | 1 2.0|
Necrosis, Focal | 2 2 | 7 2.6|
Vacuolization Cytoplasmic | | 2 3.0|
Bile Duct, Hyperplasia | 2 2 2 1 1 3 2 1 2 4 | 26 2.5|
Hepatocyte, Karyomegaly | 3 3 3 2 2 3 3 3 3 4 3 2 3 3 2 2 2| 31 2.7|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 4 | 1 4.0|
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 6| 7| 3| 5| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 7| 5| 5| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3| 2| 0| |
| 4| 1| 6| 4| 6| 0| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 1 3 | 5 2.2|
Mineralization | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 2 3 | 6 2.0|
Cytoplasmic Alteration, Focal | 2 2 2 2 2 | 7 2.0|
Hyperplasia, Focal | 1 2 | 3 1.3|
Hypertrophy, Diffuse | | 1 4.0|
Hypertrophy, Focal | 2 2 | 5 1.4|
Capsule, Hyperplasia, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + M + + + + + + + + M M + + + + + + + I + + + M| 43 |
Pars Distalis, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 2 1 1 1 3 2 | 14 1.8|
Follicle, Cyst | 3 | 4 3.0|
Follicular Cell, Hyperplasia | 1 1 1 1 1 2 3 1 | 15 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + M I + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 3 3 3 | 7 3.0|
Inflammation, Chronic | 4 4 2 4 2 2 4 2 | 13 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 6| 7| 3| 5| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 7| 5| 5| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3| 2| 0| |
| 4| 1| 6| 4| 6| 0| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 2 3 2 4 3 3 3 2 2 4 4| 23 2.9|
__________________________________________________________________________|____________|
Lymph Node | + + + +| 8 |
Mediastinal, Hemorrhage | 3 | 1 3.0|
Renal, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + I + + + + + + + + + + + + + + M + + +| 47 |
Hyperplasia, Lymphoid | 3 | 4 2.8|
Pigmentation | 2 2 | 10 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + I + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 2 2 2 | 6 2.2|
Hemorrhage | 3 1 2 3 2 2 3 4 1 1 4 | 15 2.3|
Hyperplasia, Lymphoid | 3 2 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 4 2 4 3 3 3 1 1 1 1 4 2 4 3 2 | 29 2.6|
Hyperplasia, Lymphoid | 3 3 | 4 2.8|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + I + + + + + + + + + + + + M + M + + + M +| 40 |
Atrophy | 3| 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 2 3.5|
Subcutaneous Tissue, Edema | 3 2 | 4 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 1 2 3 2 3 3 3 3 1 4 3 3 2 4 4 3 3| 31 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 6| 7| 3| 5| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 7| 5| 5| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3| 2| 0| |
| 4| 1| 6| 4| 6| 0| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 3 3 | 6 2.7|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Thrombosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 1.0|
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 2 2 1 1 1 2 2 2 1 2 2 2 1 2 1 1 1 1 2 1 3 2| 46 1.6|
Pelvis, Dilatation | | 1 1.0|
Renal Tubule, Hyaline Droplet | 1 | 1 1.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 1| 2| 1| 2| 1| 2| 1| 2| 2| 2| 1| 1| 3| 3| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 2 |
Clear Cell Focus | |
Eosinophilic Focus | 2 2 2 |
Inflammation, Chronic | 2 3 3 3 2 3 2 3 3 3 3 2 2 3 3 3 3 3 3 4 3|
Metaplasia, Osseous | 1 |
Mixed Cell Focus | 2 |
Pigmentation, Focal | 3 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 3 3 2 3 3 1 2 3 2 1 4 2 3 1 2|
Hepatocyte, Karyomegaly | 3 4 3 3 2 3 3 3 2 2 3 3 4 3 3 3 3 4 3|
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Acinus, Atrophy, Diffuse | 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 1| 2| 1| 2| 1| 2| 1| 2| 2| 2| 1| 1| 3| 3| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | 2 2 3 2 2 3 |
Hyperplasia, Focal | 1 2 1 2 |
Hypertrophy, Focal | 3 3 4 1 2 2 2 |
Capsule, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | 3|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 3 1 2 2 1|
Follicle, Cyst | 3 3 |
Follicular Cell, Hyperplasia | 1 1 1 2 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Inflammation, Chronic | 2 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Cyst | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 2 2 |
__________________________________________________________________________|
Lymph Node | + |
Bronchial, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 3 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 1| 2| 1| 2| 1| 2| 1| 2| 2| 2| 1| 1| 3| 3| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 1 2 2 2 1 3 2 3 1 |
Hyperplasia, Lymphoid | 2 2 2 2 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 4 3 3 3 3 2 1 |
Hyperplasia, Lymphoid | 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + I + + + M + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 4 3 1 3 3 3 1 2 1 3 3 3 4 3 1|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 2 |
Infiltration Cellular, Histiocyte | 3 2 |
Inflammation, Chronic | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + I + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 2 2 2 1 2 2 2 2 1 2 1 1 1 1 1 2 2 2 1 2 1 1 2|
Pelvis, Dilatation | |
Renal Tubule, Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 1| 2| 1| 2| 1| 2| 1| 2| 2| 2| 1| 1| 3| 3| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urethra | + I + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 0| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 3| 8| 9| 3| 9| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| |
| 1| 5| 9| 1| 8| 4| 1| 2| 2| 1| 2| 2| 2| 2| 2| 1| 2| 1| 5| 2| 2| 2| 2| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | X | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | | 2 2.0|
Clear Cell Focus | 3 | 1 3.0|
Eosinophilic Focus | 2 3 3| 6 2.3|
Inflammation, Chronic | 3 1 3 3 2 2 3 3 3 2 2 3 2 3 3 2 3| 38 2.7|
Metaplasia, Osseous | | 1 1.0|
Mixed Cell Focus | 3 | 2 2.5|
Pigmentation, Focal | | 1 3.0|
Vacuolization Cytoplasmic | | 1 2.0|
Bile Duct, Hyperplasia | 3 1 3 1 3 2 3 3 3 4 3| 26 2.5|
Hepatocyte, Karyomegaly | 3 4 3 3 2 3 3 3 3 2 3 4 4 3 2 3| 35 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.0|
Acinus, Atrophy, Diffuse | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 0| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 3| 8| 9| 3| 9| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| |
| 1| 5| 9| 1| 8| 4| 1| 2| 2| 1| 2| 2| 2| 2| 2| 1| 2| 1| 5| 2| 2| 2| 2| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 | 1 3.0|
Cytoplasmic Alteration, Focal | 2 2 2 1 | 10 2.1|
Hyperplasia, Focal | 2 1 1 2 | 8 1.5|
Hypertrophy, Focal | 1 1 3 2 1 2 1 | 14 2.0|
Capsule, Hyperplasia, Focal | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 2| 5 2.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 1 1 2 1 1 | 11 1.5|
Follicle, Cyst | 3 3 3 3 3 | 7 3.0|
Follicular Cell, Hyperplasia | 2 2 3 1 3 2 1 2 1 2 | 19 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 | 4 3.0|
Inflammation, Chronic | 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + I + + + + + +| 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 3 2.7|
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 0| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 3| 8| 9| 3| 9| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| |
| 1| 5| 9| 1| 8| 4| 1| 2| 2| 1| 2| 2| 2| 2| 2| 1| 2| 1| 5| 2| 2| 2| 2| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 4 4 2 3 2 2 3 | 16 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
Bronchial, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Pigmentation | 3 2 2 2 2 3 2 2 | 13 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | 2 2 3 1 1 3 3 4 | 17 2.1|
Hyperplasia, Lymphoid | 2 3 2 3 4 2 | 12 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 4 3 4 2 3 1 1 1 1 1| 17 2.4|
Hyperplasia, Lymphoid | 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | + M I + + I + + + + + + + + + M M + + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Edema | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 3 3 4 2 2 3 2 3 4 4 4 2 4 4 2 2 3 2 2 3 2| 39 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 3 | 5 2.2|
Infiltration Cellular, Histiocyte | 3 4 1 2 4 3 | 8 2.8|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 0| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 3| 8| 9| 3| 9| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| |
| 1| 5| 9| 1| 8| 4| 1| 2| 2| 1| 2| 2| 2| 2| 2| 1| 2| 1| 5| 2| 2| 2| 2| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Thrombosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 | 1 1.0|
Nephropathy | 2 2 1 1 1 1 1 2 1 1 1 2 1 1 2 2 2 2 2 1| 44 1.5|
Pelvis, Dilatation | 2 | 1 2.0|
Renal Tubule, Pigmentation | | 1 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | + + | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 8| 3| 3|
| 1| 1| 3| 3| 1| 3| 3| 3| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + I + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 3 3 2 3 3 3 2 3 2 3 2 3 3 3 2 3 3 3 3 3 3 2|
Mixed Cell Focus | 2 |
Necrosis, Focal | |
Pigmentation, Focal | 2 |
Bile Duct, Hyperplasia | 3 2 3 2 3 2 3 2 4 3 4 3 3 |
Hepatocyte, Karyomegaly | 3 3 3 3 3 3 3 2 4 3 4 2 2 4 4 2 2 3 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Epithelium, Hyperplasia | 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 3|
Inflammation, Chronic | 3 3|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | 2 1 2 2 2 2 2 1 |
Hyperplasia, Focal | 2 1 1 1 2 2|
Hypertrophy, Focal | 2 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 8| 3| 3|
| 1| 1| 3| 3| 1| 3| 3| 3| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + M +|
Cyst | 3 |
__________________________________________________________________________|
Pituitary Gland | M + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 3 1 2 2 2 2 2 2|
Follicle, Cyst | 3 3 3 |
Follicular Cell, Hyperplasia | 2 1 1 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Inflammation, Chronic | 2 2 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 3 2 3 3 4 |
__________________________________________________________________________|
Lymph Node | + + |
Bronchial, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + I + + + + M +|
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 |
Hemorrhage | 2 3 2 2 2 3 3 3 2 2 1 1 3|
Hyperplasia, Lymphoid | 3 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 3 2 3 4 2 3 3 4 |
Hyperplasia, Lymphoid | |
Necrosis, Focal | 4 |
__________________________________________________________________________|
Thymus | + + M + + I + + + + + + + + + M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 8| 3| 3|
| 1| 1| 3| 3| 1| 3| 3| 3| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
500 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 2 1 1 1 3 2 1 3 3 3 3 3 3 3 3 3 3 2|
Femur, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 2 1 4 1 1 2 1 1 1 2 2 2 1 2 1 2 2 2 3 2 1|
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urethra | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 9| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 7| 3| 2| 8| 3| 3| |
| 3| 5| 3| 1| 7| 2| 6| 1| 1| 9| 1| 7| 3| 3| 3| 3| 6| 3| 1| 2| 1| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + + + + + + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 | 1 2.0|
Clear Cell Focus | 1 | 1 1.0|
Eosinophilic Focus | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Chronic | 3 3 2 3 2 3 3 3 2 2 3 3 2 2 2 1 2 3 4 3 3 3| 44 2.7|
Mixed Cell Focus | | 1 2.0|
Necrosis, Focal | 4 2 2 4 | 4 3.0|
Pigmentation, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 3 2 2 1 2 3 4 4 3 2| 23 2.7|
Hepatocyte, Karyomegaly | 4 3 2 3 2 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3| 40 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
Epithelium, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | | 1 3.0|
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 9| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 7| 3| 2| 8| 3| 3| |
| 3| 5| 3| 1| 7| 2| 6| 1| 1| 9| 1| 7| 3| 3| 3| 3| 6| 3| 1| 2| 1| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Cytoplasmic Alteration, Focal | 2 1 2 2 | 12 1.8|
Hyperplasia, Focal | 2 1 1 1 1 2 2 2 2 2 | 16 1.6|
Hypertrophy, Focal | 1 2 2 2 2 3 | 13 1.9|
Capsule, Hyperplasia, Focal | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic, Focal | 1 1 3 2 1 1| 14 1.8|
Follicle, Cyst | 3 3 | 5 3.0|
Follicular Cell, Hyperplasia | 2 2 1 | 10 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 | 4 3.0|
Inflammation, Chronic | 4 | 4 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 2 3 3 2 2 3 3 2 4 3 | 21 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
Bronchial, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 2 2.5|
Pigmentation | 2 | 8 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + I + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 9| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 7| 3| 2| 8| 3| 3| |
| 3| 5| 3| 1| 7| 2| 6| 1| 1| 9| 1| 7| 3| 3| 3| 3| 6| 3| 1| 2| 1| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 1 2 1 | 7 1.6|
Hemorrhage | 2 2 2 2 2 | 18 2.2|
Hyperplasia, Lymphoid | 2 3 3 2 2| 8 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 4 2 4 2 2 3 3 2 3 2 3 | 23 2.8|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + M M + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 2 4.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 4 3 2 3 1 2 3 3 3 3 3 4 2 3 3 3 4 4 2| 39 2.6|
Femur, Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 4 3 2 | 4 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 89006-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/21/96
Route: GAVAGE Time: 09:46:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 2| 3| 9| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 7| 3| 2| 8| 3| 3| |
| 3| 5| 3| 1| 7| 2| 6| 1| 1| 9| 1| 7| 3| 3| 3| 3| 6| 3| 1| 2| 1| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
500 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 3 2 1 2 1 1 1 2 3 1 2 2 1 1 2 1 2 1 2 1 2 1 2| 49 1.6|
Renal Tubule, Necrosis | 3 | 1 3.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | M + + + + + | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
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---------- END OF REPORT ----------
------------------------------------------------------------