TDMS Study 89029-05 Pathology Tables
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 MERGED REPORTS FINAL #3 Facility: I. I. T. Research Institute Chemical CAS #: ELECTROMAG Lock Date: 09/04/97 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Merge 001 001,011 SHAM CONTROL Merge 002 002,012 SHAM CONTROL Merge 003 003,013 .02 GAUSS Merge 004 004,014 .02 GAUSS Merge 005 005,015 2 GAUSS Merge 006 006,016 2 GAUSS Merge 007 009,019 10 GAUSS Merge 008 010,020 10 GAUSS Merge 009 007,017 10 GAUSS INTER Merge 010 008,018 10 GAUSS INTER a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 100 100 100 100 100 Early Deaths Natural Death 18 17 18 19 19 Moribund Sacrifice 22 15 22 18 23 Survivors Terminal Sacrifice 58 66 60 59 58 Natural Death 1 1 Moribund Sacrifice 1 1 1 Other 1 2 Animals Examined Microscopically 100 100 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (100) (100) (100) (100) (97) Inflammation, Chronic Active 1 (1%) Intestine Large, Rectum (99) (100) (100) (99) (100) Inflammation, Chronic 1 (1%) Inflammation, Chronic Active 1 (1%) Intestine Large, Cecum (100) (98) (99) (100) (96) Epithelium, Hyperplasia 1 (1%) Intestine Small, Duodenum (97) (97) (96) (100) (96) Diverticulum 1 (1%) Ectopic Tissue 1 (1%) 1 (1%) Intestine Small, Ileum (94) (91) (93) (97) (91) Ulcer 1 (1%) Peyer's Patch, Hyperplasia, Lymphoid 2 (2%) Serosa, Inflammation, Chronic 1 (1%) Liver (100) (100) (100) (100) (100) Angiectasis, Focal 1 (1%) 1 (1%) 2 (2%) 3 (3%) Basophilic Focus 66 (66%) 82 (82%) 77 (77%) 66 (66%) 78 (78%) Clear Cell Focus 6 (6%) 13 (13%) 18 (18%) 13 (13%) 18 (18%) Congestion 1 (1%) Eosinophilic Focus 18 (18%) 24 (24%) 30 (30%) 24 (24%) 31 (31%) Fibrosis 2 (2%) 1 (1%) 1 (1%) 1 (1%) Hematopoietic Cell Proliferation 6 (6%) 3 (3%) 2 (2%) 4 (4%) 2 (2%) Hepatodiaphragmatic Nodule 8 (8%) 4 (4%) 4 (4%) 5 (5%) 6 (6%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) 4 (4%) 2 (2%) Infiltration Cellular, Histiocyte 2 (2%) 1 (1%) Infiltration Cellular, Mixed Cell 32 (32%) 40 (40%) 37 (37%) 28 (28%) 27 (27%) Inflammation, Chronic 1 (1%) 1 (1%) 2 (2%) 2 (2%) 2 (2%) Inflammation, Chronic Active 1 (1%) Inflammation, Granulomatous 2 (2%) Mixed Cell Focus 39 (39%) 45 (45%) 49 (49%) 42 (42%) 37 (37%) Necrosis 3 (3%) 4 (4%) 7 (7%) 4 (4%) 4 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Pigmentation 1 (1%) Tension Lipidosis, Focal 1 (1%) 1 (1%) 1 (1%) Bile Duct, Hyperplasia 28 (28%) 20 (20%) 31 (31%) 21 (21%) 24 (24%) Hepatocyte, Hypertrophy 1 (1%) Hepatocyte, Vacuolization Cytoplasmic 11 (11%) 12 (12%) 9 (9%) 11 (11%) 9 (9%) Mesentery (11) (6) (5) (13) (16) Accessory Spleen 1 (9%) 1 (8%) Fat, Necrosis 9 (82%) 4 (67%) 4 (80%) 10 (77%) 15 (94%) Pancreas (100) (100) (99) (100) (99) Infiltration Cellular, Lymphocyte 14 (14%) 10 (10%) 9 (9%) 9 (9%) 7 (7%) Metaplasia, Hepatocyte 2 (2%) Acinus, Atrophy, Diffuse 3 (3%) 1 (1%) 2 (2%) Acinus, Atrophy, Focal 15 (15%) 18 (18%) 26 (26%) 16 (16%) 20 (20%) Acinus, Basophilic Focus 2 (2%) Acinus, Hyperplasia, Focal 3 (3%) 5 (5%) 5 (5%) 1 (1%) 2 (2%) Artery, Inflammation, Chronic 1 (1%) Duct, Hyperplasia 1 (1%) 1 (1%) Salivary Glands (100) (99) (100) (100) (100) Pigmentation 1 (1%) Duct, Parotid Gland, Hyperplasia 1 (1%) Duct, Parotid Gland, Mineralization 1 (1%) Duct, Sublingual Gland, Metaplasia, Squamous 1 (1%) 2 (2%) Parotid Gland, Atrophy 3 (3%) 2 (2%) 3 (3%) 2 (2%) 2 (2%) Parotid Gland, Hyperplasia 1 (1%) 1 (1%) Parotid Gland, Inflammation, Acute 1 (1%) Parotid Gland, Inflammation, Chronic 1 (1%) Sublingual Gland, Atrophy 1 (1%) 1 (1%) 1 (1%) 1 (1%) Sublingual Gland, Infiltration Cellular, Lymphocyte 1 (1%) Sublingual Gland, Metaplasia, Squamous 1 (1%) Submandibular Gland, Infiltration Cellular, Lymphocyte 1 (1%) Stomach, Forestomach (100) (99) (99) (100) (100) Edema 3 (3%) 1 (1%) 3 (3%) Erosion, Focal 1 (1%) Inflammation, Acute 1 (1%) 1 (1%) 1 (1%) Inflammation, Chronic 1 (1%) 1 (1%) Inflammation, Chronic Active 1 (1%) 2 (2%) Ulcer 3 (3%) 1 (1%) 3 (3%) 1 (1%) Epithelium, Hyperplasia 7 (7%) 2 (2%) 3 (3%) 10 (10%) Stomach, Glandular (100) (100) (99) (100) (100) Edema 1 (1%) 1 (1%) Erosion, Focal 5 (5%) 2 (2%) 2 (2%) 5 (5%) 3 (3%) Fibrosis 1 (1%) Inflammation, Chronic Active 1 (1%) Metaplasia, Focal, Squamous 1 (1%) Necrosis, Focal 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Glands, Congestion 1 (1%) Glands, Cyst 12 (12%) 20 (20%) 26 (26%) 12 (12%) 12 (12%) Muscularis, Mineralization 1 (1%) Tongue (1) (1) (2) (1) Epithelium, Hyperplasia, Focal 1 (100%) 1 (100%) 1 (50%) 1 (100%) Tooth (2) (1) (1) (1) (1) Inflammation, Chronic 1 (100%) Malformation 1 (50%) 1 (100%) Necrosis 1 (100%) Gingiva, Inflammation, Chronic Active 1 (100%) Peridontal Tissue, Inflammation, Chronic Active 1 (50%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (99) (100) (100) (100) (100) Inflammation, Chronic 1 (1%) Heart (100) (100) (100) (100) (100) Cardiomyopathy 53 (53%) 71 (71%) 64 (64%) 61 (61%) 60 (60%) Artery, Inflammation, Chronic 1 (1%) Atrium, Mineralization 1 (1%) Atrium, Thrombosis 1 (1%) 2 (2%) Endocardium, Inflammation, Chronic 1 (1%) Myocardium, Fibrosis, Focal 1 (1%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (100) (100) (100) (100) (100) Angiectasis 1 (1%) 4 (4%) 4 (4%) 1 (1%) 5 (5%) Degeneration 1 (1%) 1 (1%) Hematopoietic Cell Proliferation 1 (1%) 2 (2%) 4 (4%) 2 (2%) Hemorrhage 1 (1%) Hyperplasia, Focal 11 (11%) 23 (23%) 12 (12%) 8 (8%) 15 (15%) Hypertrophy, Focal 3 (3%) 1 (1%) 5 (5%) 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) Inflammation, Chronic 1 (1%) Mineralization 1 (1%) 1 (1%) Necrosis 1 (1%) 2 (2%) 1 (1%) 1 (1%) Vacuolization Cytoplasmic, Diffuse 1 (1%) 2 (2%) 1 (1%) Vacuolization Cytoplasmic, Focal 27 (27%) 27 (27%) 24 (24%) 31 (31%) 24 (24%) Bilateral, Angiectasis 57 (57%) 51 (51%) 46 (46%) 58 (58%) 57 (57%) Bilateral, Hematopoietic Cell Proliferation 2 (2%) 3 (3%) 4 (4%) 2 (2%) Bilateral, Hyperplasia, Focal 1 (1%) 2 (2%) 1 (1%) Bilateral, Infiltration Cellular, Lymphocyte 1 (1%) Bilateral, Infiltration Cellular, Mixed Cell 1 (1%) 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Bilateral, Inflammation, Chronic 1 (1%) 1 (1%) Bilateral, Necrosis 1 (1%) 1 (1%) Bilateral, Pigmentation 2 (2%) 2 (2%) Bilateral, Vacuolization Cytoplasmic, Diffuse 1 (1%) Bilateral, Vacuolization Cytoplasmic, Focal 2 (2%) 3 (3%) 2 (2%) 3 (3%) 3 (3%) Adrenal Medulla (96) (94) (94) (98) (97) Hyperplasia, Focal 6 (6%) 6 (6%) 4 (4%) 7 (7%) 4 (4%) Bilateral, Hyperplasia, Focal 1 (1%) Bilateral, Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Bilateral, Necrosis 1 (1%) Islets, Pancreatic (100) (100) (99) (100) (99) Hyperplasia, Focal 1 (1%) 1 (1%) Parathyroid Gland (88) (94) (91) (88) (92) Cyst 1 (1%) 1 (1%) Degeneration 1 (1%) Hyperplasia, Focal 1 (1%) Pineal Gland (85) (90) (85) (90) (89) Fibrosis 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) Mineralization 56 (66%) 54 (60%) 57 (67%) 54 (60%) 40 (45%) Pituitary Gland (99) (99) (98) (98) (98) Pars Distalis, Angiectasis 1 (1%) 1 (1%) Pars Distalis, Angiectasis, Focal 1 (1%) 9 (9%) 5 (5%) 3 (3%) 2 (2%) Pars Distalis, Cyst 21 (21%) 21 (21%) 19 (19%) 28 (29%) 25 (26%) Pars Distalis, Degeneration, Focal 1 (1%) Pars Distalis, Hyperplasia, Diffuse 1 (1%) Pars Distalis, Hyperplasia, Focal 10 (10%) 9 (9%) 6 (6%) 6 (6%) 7 (7%) Pars Distalis, Hypertrophy, Focal 1 (1%) 1 (1%) Pars Distalis, Inflammation, Chronic 2 (2%) 1 (1%) 1 (1%) Pars Distalis, Pigmentation 2 (2%) 1 (1%) 2 (2%) 1 (1%) Pars Intermedia, Hyperplasia, Focal 1 (1%) 1 (1%) 1 (1%) Rathke's Cleft, Cyst 2 (2%) 2 (2%) Rathke's Cleft, Hemorrhage 1 (1%) Rathke's Cleft, Pigmentation 1 (1%) 1 (1%) 1 (1%) Thyroid Gland (100) (100) (100) (100) (100) Infiltration Cellular, Lymphocyte 1 (1%) Ultimobranchial Cyst 2 (2%) 4 (4%) 7 (7%) 3 (3%) 3 (3%) C-Cell, Hyperplasia 18 (18%) 5 (5%) C-Cell, Hyperplasia, Diffuse 2 (2%) 1 (1%) 3 (3%) 2 (2%) C-Cell, Hyperplasia, Focal 20 (20%) 39 (39%) 52 (52%) 24 (24%) 30 (30%) Follicle, Cyst 1 (1%) 1 (1%) 1 (1%) 1 (1%) Follicular Cell, Hyperplasia, Focal 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (90) (96) (97) (96) (94) Cyst 1 (1%) 7 (7%) 1 (1%) 3 (3%) Hyperplasia, Focal 6 (7%) 4 (4%) 3 (3%) 5 (5%) 5 (5%) Inflammation, Acute 1 (1%) 1 (1%) Inflammation, Chronic 15 (17%) 9 (9%) 13 (13%) 23 (24%) 12 (13%) Inflammation, Chronic Active 7 (7%) 2 (2%) 5 (5%) 1 (1%) Bilateral, Atrophy 1 (1%) Bilateral, Inflammation, Chronic 8 (9%) 2 (2%) 4 (4%) 2 (2%) 7 (7%) Bilateral, Inflammation, Chronic Active 2 (2%) 2 (2%) Ovary (100) (100) (100) (100) (99) Inflammation, Chronic 1 (1%) 1 (1%) 1 (1%) 2 (2%) Mineralization 1 (1%) Bilateral, Atrophy 1 (1%) 2 (2%) 1 (1%) Bilateral, Inflammation, Chronic 3 (3%) 2 (2%) 3 (3%) 1 (1%) 2 (2%) Bilateral, Pigmentation 2 (2%) Bilateral, Periovarian Tissue, Cyst 2 (2%) Bilateral, Follicle, Cyst 1 (1%) Bilateral, Rete Ovarii, Hyperplasia 3 (3%) 2 (2%) 3 (3%) 1 (1%) 3 (3%) Follicle, Cyst 3 (3%) 5 (5%) 1 (1%) 4 (4%) 2 (2%) Interstitial Cell, Hyperplasia 1 (1%) Periovarian Tissue, Cyst 6 (6%) 6 (6%) 12 (12%) 8 (8%) 11 (11%) Rete Ovarii, Hyperplasia 5 (5%) 14 (14%) 5 (5%) 14 (14%) 13 (13%) Uterus (100) (100) (100) (100) (99) Hemorrhage 1 (1%) 2 (2%) Hydrometra 9 (9%) 10 (10%) 8 (8%) 7 (7%) 6 (6%) Pigmentation 2 (2%) 1 (1%) 1 (1%) 1 (1%) Cervix, Cyst 2 (2%) Cervix, Inflammation, Chronic Active 2 (2%) 1 (1%) 1 (1%) 1 (1%) Cervix, Epithelium, Vacuolization Cytoplasmic 1 (1%) Endometrium, Angiectasis, Focal 1 (1%) Endometrium, Cyst 3 (3%) 3 (3%) 4 (4%) 1 (1%) 9 (9%) Endometrium, Cytoplasmic Alteration 1 (1%) Endometrium, Fibrosis 1 (1%) 1 (1%) 2 (2%) Endometrium, Hyperplasia 1 (1%) Endometrium, Inflammation, Acute 1 (1%) Endometrium, Inflammation, Chronic 1 (1%) 3 (3%) 3 (3%) 1 (1%) Endometrium, Inflammation, Chronic Active 2 (2%) Endometrium, Pigmentation 2 (2%) 1 (1%) Endometrium, Epithelium, Hyperplasia 1 (1%) 1 (1%) Serosa, Fibrosis 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Vagina (1) (1) (2) (2) Cyst 1 (50%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (100) (100) (100) (100) (100) Depletion Cellular 9 (9%) 5 (5%) 6 (6%) 4 (4%) 11 (11%) Hyperplasia 13 (13%) 19 (19%) 13 (13%) 12 (12%) 17 (17%) Inflammation, Chronic 1 (1%) Myelofibrosis 1 (1%) 1 (1%) Lymph Node (16) (5) (5) (10) (18) Pigmentation 2 (13%) Inguinal, Degeneration, Cystic 1 (20%) Inguinal, Hyperplasia, Lymphoid 1 (6%) 1 (20%) Mediastinal, Hemorrhage 1 (6%) 1 (20%) 1 (10%) 3 (17%) Mediastinal, Pigmentation 1 (6%) 1 (20%) Pancreatic, Infiltration Cellular, Histiocyte 1 (20%) Lymph Node, Mandibular (100) (99) (100) (100) (100) Atrophy 1 (1%) Congestion 2 (2%) Degeneration, Cystic 11 (11%) 19 (19%) 4 (4%) 8 (8%) 15 (15%) Hemorrhage 1 (1%) 2 (2%) 3 (3%) 2 (2%) 3 (3%) Hyperplasia, Lymphoid 13 (13%) 21 (21%) 11 (11%) 7 (7%) 7 (7%) Infiltration Cellular, Histiocyte 3 (3%) 1 (1%) 2 (2%) 1 (1%) Pigmentation 2 (2%) 2 (2%) 3 (3%) Lymph Node, Mesenteric (100) (99) (99) (99) (99) Angiectasis 1 (1%) Degeneration, Cystic 2 (2%) 1 (1%) 1 (1%) Hemorrhage 3 (3%) 3 (3%) 2 (2%) 4 (4%) 4 (4%) Hyperplasia, Lymphoid 1 (1%) 2 (2%) Infiltration Cellular, Histiocyte 85 (85%) 92 (93%) 86 (87%) 87 (88%) 86 (87%) Spleen (100) (100) (100) (100) (99) Congestion 1 (1%) 1 (1%) Depletion Cellular, Focal 1 (1%) 1 (1%) 2 (2%) Fibrosis 1 (1%) 2 (2%) Hematopoietic Cell Proliferation 15 (15%) 15 (15%) 20 (20%) 13 (13%) 28 (28%) Infiltration Cellular, Histiocyte 2 (2%) Pigmentation 54 (54%) 48 (48%) 56 (56%) 57 (57%) 46 (46%) Capsule, Fibrosis 1 (1%) Lymphoid Follicle, Atrophy 6 (6%) 3 (3%) 3 (3%) 4 (4%) 6 (6%) Lymphoid Follicle, Hyperplasia 1 (1%) 1 (1%) Thymus (95) (95) (92) (91) (92) Atrophy 51 (54%) 48 (51%) 47 (51%) 48 (53%) 43 (47%) Cyst 1 (1%) 3 (3%) 5 (5%) 2 (2%) 2 (2%) Ectopic Parathyroid Gland 1 (1%) Hemorrhage 2 (2%) 1 (1%) 3 (3%) 6 (7%) 5 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hyperplasia, Lymphoid 1 (1%) Epithelial Cell, Hyperplasia 3 (3%) 1 (1%) 3 (3%) 4 (4%) 2 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (100) (100) (100) (100) (100) Cyst 47 (47%) 54 (54%) 56 (56%) 61 (61%) 53 (53%) Fibrosis 2 (2%) Galactocele 10 (10%) 7 (7%) 14 (14%) 7 (7%) 10 (10%) Inflammation, Chronic 1 (1%) 2 (2%) 2 (2%) 2 (2%) Mineralization 2 (2%) Epithelium, Hyperplasia 1 (1%) 4 (4%) 3 (3%) 2 (2%) 3 (3%) Skin (100) (100) (100) (100) (100) Cyst Epithelial Inclusion 1 (1%) 1 (1%) Hyperkeratosis 1 (1%) 1 (1%) Hyperkeratosis, Focal 1 (1%) Inflammation, Chronic 1 (1%) 1 (1%) 1 (1%) Inflammation, Chronic Active 1 (1%) 1 (1%) Inflammation, Chronic Active, Focal 1 (1%) Dermis, Fibrosis, Focal 1 (1%) Epidermis, Hyperplasia, Diffuse 1 (1%) Epidermis, Lip, Hyperplasia, Focal 1 (1%) Nipple, Hyperkeratosis 1 (1%) Subcutaneous Tissue, Inflammation, Chronic 1 (1%) Subcutaneous Tissue, Necrosis 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (100) (100) (100) (100) (100) Cranium, Hyperostosis 7 (7%) 1 (1%) 5 (5%) 5 (5%) 2 (2%) Femur, Hyperostosis 20 (20%) 10 (10%) 20 (20%) 18 (18%) 13 (13%) Intervertebral Disc, Degeneration 1 (1%) Maxilla, Hyperostosis 1 (1%) 1 (1%) Turbinate, Hyperostosis 7 (7%) 3 (3%) 9 (9%) 11 (11%) 6 (6%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (100) (100) (100) (100) (100) Mineralization 1 (1%) Cerebellum, Gliosis, Focal 1 (1%) Cerebellum, Hemorrhage 2 (2%) Cerebrum, Infiltration Cellular, Lymphocyte 1 (1%) Cerebrum, Mineralization 2 (2%) Hypothalamus, Compression 16 (16%) 9 (9%) 16 (16%) 15 (15%) 19 (19%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - CONT Pons, Compression 2 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (1) (1) (1) (1) (1) Inflammation, Chronic 1 (100%) Lung (100) (100) (100) (100) (100) Congestion 5 (5%) 7 (7%) 4 (4%) 6 (6%) 7 (7%) Emphysema 1 (1%) Hemorrhage 1 (1%) 2 (2%) 1 (1%) 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) 6 (6%) 4 (4%) 7 (7%) 3 (3%) Infiltration Cellular, Histiocyte 31 (31%) 42 (42%) 34 (34%) 46 (46%) 35 (35%) Infiltration Cellular, Mixed Cell 2 (2%) 5 (5%) Metaplasia, Focal, Osseous 1 (1%) Mineralization 1 (1%) Pigmentation 1 (1%) 1 (1%) 1 (1%) Alveolar Epithelium, Hyperplasia, Focal 4 (4%) 3 (3%) 4 (4%) 1 (1%) 3 (3%) Interstitium, Inflammation, Chronic 10 (10%) 20 (20%) 13 (13%) 4 (4%) 7 (7%) Serosa, Inflammation, Chronic 1 (1%) 1 (1%) Nose (100) (100) (100) (100) (100) Inflammation, Acute 1 (1%) 2 (2%) Inflammation, Chronic 1 (1%) 2 (2%) 4 (4%) 1 (1%) 3 (3%) Inflammation, Chronic Active 8 (8%) 8 (8%) 7 (7%) 5 (5%) 7 (7%) Glands, Cyst 1 (1%) Nasolacrimal Duct, Inflammation, Acute 1 (1%) 2 (2%) Nasolacrimal Duct, Inflammation, Chronic 2 (2%) 6 (6%) 4 (4%) 1 (1%) 7 (7%) Nasolacrimal Duct, Inflammation, Chronic Active 3 (3%) 2 (2%) 1 (1%) Olfactory Epithelium, Cytoplasmic Alteration 69 (69%) 83 (83%) 87 (87%) 74 (74%) 77 (77%) Olfactory Epithelium, Mineralization, Focal 1 (1%) Respiratory Epithelium, Cytoplasmic Alteration 4 (4%) 1 (1%) 3 (3%) 5 (5%) 1 (1%) Trachea (100) (100) (100) (100) (100) Inflammation, Chronic 6 (6%) 1 (1%) 7 (7%) 7 (7%) 5 (5%) Inflammation, Chronic Active 1 (1%) Glands, Cyst 2 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (6) (4) (7) (6) (3) Atrophy 2 (29%) 1 (17%) Bilateral, Cornea, Mineralization 1 (33%) Bilateral, Iris, Synechia 1 (17%) Bilateral, Lens, Cataract 1 (17%) 1 (14%) 1 (17%) Bilateral, Retina, Atrophy 1 (17%) 1 (14%) 1 (17%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - CONT Cornea, Inflammation, Acute 1 (14%) Cornea, Inflammation, Chronic Active 1 (17%) Iris, Synechia 1 (17%) Lens, Cataract 5 (83%) 4 (100%) 4 (57%) 3 (50%) 2 (67%) Retina, Atrophy 5 (83%) 4 (100%) 4 (57%) 3 (50%) 2 (67%) Harderian Gland (100) (100) (100) (100) (100) Atrophy, Focal 1 (1%) 2 (2%) 2 (2%) 3 (3%) Cyst 1 (1%) Hyperplasia, Focal 1 (1%) 2 (2%) 2 (2%) Infiltration Cellular, Lymphocyte 34 (34%) 33 (33%) 33 (33%) 28 (28%) 27 (27%) Inflammation, Chronic 4 (4%) 3 (3%) 5 (5%) 6 (6%) 2 (2%) Mineralization 1 (1%) Pigmentation 1 (1%) Bilateral, Infiltration Cellular, Lymphocyte 35 (35%) 40 (40%) 32 (32%) 28 (28%) 39 (39%) Bilateral, Inflammation, Chronic 6 (6%) 6 (6%) 11 (11%) 9 (9%) 12 (12%) Bilateral, Inflammation, Chronic Active 1 (1%) Lacrimal Gland (2) (1) (1) (4) Inflammation, Chronic 1 (25%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (100) (100) (100) (100) (100) Hydronephrosis 1 (1%) Infarct 1 (1%) 1 (1%) 1 (1%) 1 (1%) Infiltration Cellular, Lymphocyte 2 (2%) 1 (1%) Inflammation, Chronic Active 1 (1%) Mineralization 13 (13%) 12 (12%) 18 (18%) 11 (11%) 23 (23%) Bilateral, Infiltration Cellular, Lymphocyte 1 (1%) Bilateral, Mineralization 10 (10%) 12 (12%) 11 (11%) 6 (6%) 16 (16%) Bilateral, Necrosis, Chronic 1 (1%) Bilateral, Nephropathy 54 (54%) 46 (46%) 69 (69%) 46 (46%) 51 (51%) Bilateral, Pigmentation 2 (2%) 1 (1%) Bilateral, Artery, Hypertrophy 1 (1%) Bilateral, Medulla, Inflammation, Chronic 1 (1%) Bilateral, Pelvis, Inflammation, Acute 1 (1%) Bilateral, Pelvis, Inflammation, Chronic 2 (2%) 1 (1%) Bilateral, Pelvis, Inflammation, Chronic Active 1 (1%) Bilateral, Pelvis, Transitional Epithelium, Hyperplasia 2 (2%) Bilateral, Renal Tubule, Accumulation, Hyaline Droplet 5 (5%) 2 (2%) 3 (3%) 3 (3%) Bilateral, Renal Tubule, Degeneration 2 (2%) 2 (2%) 1 (1%) 2 (2%) 3 (3%) Bilateral, Renal Tubule, Dilatation 1 (1%) Bilateral, Renal Tubule, Pigmentation 26 (26%) 11 (11%) 13 (13%) 30 (30%) 11 (11%) Capsule, Fibrosis, Focal 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Pelvis, Dilatation 1 (1%) 1 (1%) Pelvis, Inflammation, Acute 1 (1%) Pelvis, Inflammation, Chronic 2 (2%) 1 (1%) 2 (2%) Pelvis, Inflammation, Chronic Active 3 (3%) 1 (1%) Pelvis, Transitional Epithelium, Hyperplasia 2 (2%) 1 (1%) 1 (1%) 1 (1%) Renal Tubule, Hyperplasia, Focal 1 (1%) 1 (1%) Renal Tubule, Necrosis 1 (1%) Urinary Bladder (99) (97) (99) (99) (96) Calculus Micro Observation Only 1 (1%) Edema 1 (1%) 1 (1%) Infiltration Cellular, Lymphocyte 10 (10%) 9 (9%) 9 (9%) 5 (5%) 10 (10%) Inflammation, Chronic 1 (1%) 2 (2%) 1 (1%) 1 (1%) Transitional Epithelium, Hyperplasia 2 (2%) 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 100 100 100 100 100 Early Deaths Moribund Sacrifice 29 32 32 36 33 Natural Death 14 21 21 16 7 Survivors Terminal Sacrifice 57 46 47 48 59 Other 1 1 Animals Examined Microscopically 100 100 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (100) (99) (99) (100) (99) Inflammation, Chronic 1 (1%) Parasite Metazoan 1 (1%) Intestine Large, Rectum (99) (100) (100) (99) (100) Edema 1 (1%) Ulcer 1 (1%) Intestine Large, Cecum (98) (99) (97) (100) (99) Edema 1 (1%) 1 (1%) 1 (1%) Inflammation, Chronic Active 1 (1%) Parasite Metazoan 1 (1%) Intestine Small, Duodenum (99) (94) (100) (100) (98) Inflammation, Acute 1 (1%) Intestine Small, Ileum (94) (92) (97) (96) (97) Inflammation, Chronic 1 (1%) 1 (1%) Peyer's Patch, Hyperplasia, Lymphoid 2 (2%) 1 (1%) Liver (100) (100) (100) (100) (100) Angiectasis, Focal 1 (1%) 3 (3%) 1 (1%) Atrophy 1 (1%) Atypia Cellular, Focal 1 (1%) Basophilic Focus 35 (35%) 35 (35%) 47 (47%) 37 (37%) 36 (36%) Clear Cell Focus 44 (44%) 37 (37%) 38 (38%) 35 (35%) 41 (41%) Degeneration, Cystic, Focal 8 (8%) 2 (2%) 11 (11%) 13 (13%) 5 (5%) Eosinophilic Focus 21 (21%) 19 (19%) 26 (26%) 17 (17%) 17 (17%) Hematopoietic Cell Proliferation 5 (5%) 4 (4%) 6 (6%) 3 (3%) 2 (2%) Hepatodiaphragmatic Nodule 2 (2%) 5 (5%) 7 (7%) 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) 2 (2%) Infiltration Cellular, Mixed Cell 11 (11%) 15 (15%) 9 (9%) 14 (14%) 26 (26%) Inflammation, Chronic 2 (2%) 1 (1%) 1 (1%) 3 (3%) Inflammation, Chronic Active 1 (1%) Mixed Cell Focus 25 (25%) 28 (28%) 25 (25%) 23 (23%) 18 (18%) Necrosis 8 (8%) 6 (6%) 6 (6%) 4 (4%) 2 (2%) Pigmentation 1 (1%) 1 (1%) 2 (2%) Tension Lipidosis 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Artery, Inflammation, Chronic 1 (1%) Bile Duct, Hyperplasia 79 (79%) 88 (88%) 88 (88%) 74 (74%) 79 (79%) Centrilobular, Necrosis 1 (1%) Hepatocyte, Degeneration 1 (1%) Hepatocyte, Hypertrophy 1 (1%) Hepatocyte, Vacuolization Cytoplasmic 14 (14%) 13 (13%) 19 (19%) 19 (19%) 20 (20%) Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (1%) 1 (1%) Mesentery (17) (22) (27) (21) (16) Accessory Spleen 2 (13%) Inflammation, Chronic 1 (4%) Artery, Hemorrhage 1 (5%) Artery, Inflammation, Chronic 1 (6%) Fat, Necrosis 14 (82%) 15 (68%) 23 (85%) 15 (71%) 13 (81%) Pancreas (98) (99) (99) (99) (100) Cyst 3 (3%) 1 (1%) 1 (1%) 1 (1%) Fibrosis, Focal 1 (1%) Hemorrhage 1 (1%) Infiltration Cellular, Lymphocyte 5 (5%) 14 (14%) 13 (13%) 9 (9%) 3 (3%) Acinus, Atrophy, Diffuse 3 (3%) 1 (1%) 1 (1%) 1 (1%) Acinus, Atrophy, Focal 33 (34%) 26 (26%) 40 (40%) 27 (27%) 41 (41%) Acinus, Basophilic Focus 1 (1%) 1 (1%) 1 (1%) 1 (1%) Acinus, Hyperplasia, Focal 20 (20%) 21 (21%) 23 (23%) 20 (20%) 18 (18%) Acinus, Inflammation, Chronic 1 (1%) 1 (1%) Artery, Inflammation, Chronic 1 (1%) 2 (2%) 2 (2%) 1 (1%) Salivary Glands (99) (99) (100) (100) (100) Mineralization 1 (1%) Bilateral, Pigmentation 1 (1%) Parotid Gland, Atrophy 2 (2%) 2 (2%) Parotid Gland, Fibrosis, Focal 1 (1%) Parotid Gland, Hyperplasia, Focal 1 (1%) 1 (1%) Parotid Gland, Inflammation, Chronic 1 (1%) Parotid Gland, Vacuolization Cytoplasmic, Diffuse 1 (1%) Sublingual Gland, Atrophy 1 (1%) 1 (1%) Sublingual Gland, Infiltration Cellular, Lymphocyte 1 (1%) Sublingual Gland, Inflammation, Chronic 1 (1%) Submandibular Gland, Atrophy 1 (1%) Stomach, Forestomach (100) (100) (100) (100) (100) Edema 3 (3%) 3 (3%) 5 (5%) 3 (3%) 6 (6%) Erosion, Focal 1 (1%) 1 (1%) 1 (1%) Inflammation, Acute 1 (1%) 1 (1%) 1 (1%) Inflammation, Chronic 1 (1%) 1 (1%) 3 (3%) Inflammation, Chronic Active 2 (2%) 1 (1%) 4 (4%) 4 (4%) 1 (1%) Ulcer 1 (1%) 2 (2%) 2 (2%) 3 (3%) 7 (7%) Epithelium, Hyperplasia 6 (6%) 5 (5%) 9 (9%) 2 (2%) 7 (7%) Stomach, Glandular (100) (100) (100) (100) (100) a Number of animals examined microscopically at site and number of animals with lesion Page 13 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Atrophy 3 (3%) Edema 2 (2%) 1 (1%) Erosion, Focal 9 (9%) 3 (3%) 9 (9%) 8 (8%) 11 (11%) Hyperplasia, Focal 1 (1%) 1 (1%) Inflammation, Acute 1 (1%) 1 (1%) Inflammation, Chronic 1 (1%) Inflammation, Chronic Active 1 (1%) 1 (1%) 1 (1%) Mineralization 1 (1%) 1 (1%) Ulcer 1 (1%) Artery, Inflammation, Chronic 1 (1%) 1 (1%) Epithelium, Cyst 1 (1%) Glands, Cyst 4 (4%) 6 (6%) 1 (1%) 3 (3%) 2 (2%) Muscularis, Mineralization 1 (1%) Tooth (2) (1) (1) (1) (6) Malformation 5 (83%) Gingiva, Inflammation, Chronic Active 2 (100%) 1 (100%) 1 (17%) Gingiva, Malformation 1 (50%) Peridontal Tissue, Inflammation, Chronic Active 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (99) (99) (99) (100) (100) Aneurysm 1 (1%) Inflammation, Chronic 1 (1%) Mineralization 1 (1%) 1 (1%) Heart (100) (100) (100) (100) (100) Cardiomyopathy 88 (88%) 87 (87%) 88 (88%) 87 (87%) 87 (87%) Metaplasia, Focal, Osseous 1 (1%) Pigmentation 2 (2%) Artery, Inflammation, Chronic 1 (1%) Artery, Mineralization 1 (1%) 1 (1%) Atrium, Mineralization 1 (1%) Atrium, Thrombosis 6 (6%) 6 (6%) 6 (6%) 9 (9%) 4 (4%) Epicardium, Inflammation, Chronic 1 (1%) Myocardium, Necrosis 1 (1%) Pericardium, Inflammation, Chronic 1 (1%) Valve, Inflammation, Chronic 1 (1%) 2 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (99) (100) (100) (100) (100) Accessory Adrenal Cortical Nodule 1 (1%) 2 (2%) 3 (3%) Angiectasis 4 (4%) 1 (1%) Degeneration, Focal 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 14 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Hematopoietic Cell Proliferation 1 (1%) 4 (4%) 3 (3%) 2 (2%) 6 (6%) Hemorrhage 1 (1%) 1 (1%) Hyperplasia, Focal 11 (11%) 15 (15%) 9 (9%) 11 (11%) 9 (9%) Hypertrophy, Focal 3 (3%) 3 (3%) 6 (6%) 3 (3%) Necrosis, Focal 2 (2%) Pigmentation 1 (1%) Vacuolization Cytoplasmic, Focal 14 (14%) 19 (19%) 19 (19%) 20 (20%) 19 (19%) Bilateral, Angiectasis 5 (5%) 8 (8%) 2 (2%) 2 (2%) 2 (2%) Bilateral, Hematopoietic Cell Proliferation 2 (2%) 3 (3%) 2 (2%) 3 (3%) Bilateral, Hyperplasia, Focal 1 (1%) Bilateral, Infiltration Cellular, Mixed Cell 1 (1%) Bilateral, Necrosis 1 (1%) Bilateral, Pigmentation 1 (1%) 1 (1%) 1 (1%) Bilateral, Vacuolization Cytoplasmic, Diffuse 1 (1%) 2 (2%) 4 (4%) 3 (3%) Bilateral, Vacuolization Cytoplasmic, Focal 6 (6%) 5 (5%) 4 (4%) 5 (5%) 1 (1%) Adrenal Medulla (98) (93) (100) (100) (95) Degeneration, Cystic 1 (1%) Hyperplasia, Focal 14 (14%) 11 (12%) 9 (9%) 16 (16%) 13 (14%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Thrombosis 1 (1%) Bilateral, Hyperplasia, Focal 3 (3%) 5 (5%) 2 (2%) 2 (2%) 1 (1%) Bilateral, Infiltration Cellular, Lymphocyte 1 (1%) Islets, Pancreatic (99) (99) (99) (99) (100) Hyperplasia, Focal 1 (1%) 1 (1%) 9 (9%) 2 (2%) 7 (7%) Inflammation, Chronic, Focal 1 (1%) Metaplasia, Focal 1 (1%) Parathyroid Gland (85) (87) (93) (81) (89) Hyperplasia, Focal 1 (1%) 1 (1%) 1 (1%) Pineal Gland (81) (84) (81) (79) (91) Fibrosis 1 (1%) Hyperplasia, Focal 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) 2 (2%) Mineralization 42 (52%) 52 (62%) 54 (67%) 39 (49%) 57 (63%) Pituitary Gland (98) (95) (97) (100) (98) Inflammation, Granulomatous 1 (1%) Pars Distalis, Angiectasis, Focal 3 (3%) 2 (2%) 4 (4%) 2 (2%) 2 (2%) Pars Distalis, Atrophy, Focal 1 (1%) Pars Distalis, Cyst 8 (8%) 6 (6%) 6 (6%) 16 (16%) 7 (7%) Pars Distalis, Hemorrhage 1 (1%) Pars Distalis, Hyperplasia, Focal 11 (11%) 15 (16%) 9 (9%) 14 (14%) 16 (16%) Pars Distalis, Hypertrophy, Focal 2 (2%) 2 (2%) 3 (3%) 2 (2%) Pars Distalis, Pigmentation, Focal 1 (1%) Pars Distalis, Vacuolization Cytoplasmic 2 (2%) 1 (1%) 1 (1%) Pars Distalis, Vacuolization Cytoplasmic, Focal 1 (1%) Pars Intermedia, Atypia Cellular 1 (1%) Pars Intermedia, Cyst 3 (3%) 1 (1%) 2 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 15 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Intermedia, Hyperplasia, Focal 1 (1%) Pars Nervosa, Atypia Cellular 1 (1%) Pars Nervosa, Cyst 1 (1%) Pars Nervosa, Degeneration, Focal 1 (1%) Rathke's Cleft, Cyst 1 (1%) 1 (1%) 1 (1%) Thyroid Gland (99) (100) (100) (100) (100) Hemorrhage 1 (1%) Inflammation, Chronic 2 (2%) 2 (2%) Mineralization 1 (1%) Ultimobranchial Cyst 1 (1%) 1 (1%) 4 (4%) 7 (7%) 3 (3%) Bilateral, C-Cell, Hyperplasia, Focal 1 (1%) 1 (1%) C-Cell, Hyperplasia 1 (1%) 3 (3%) 1 (1%) 2 (2%) C-Cell, Hyperplasia, Diffuse 4 (4%) 1 (1%) C-Cell, Hyperplasia, Focal 28 (28%) 22 (22%) 23 (23%) 24 (24%) 31 (31%) Follicle, Cyst 3 (3%) 2 (2%) 5 (5%) 2 (2%) 3 (3%) Follicular Cell, Hyperplasia, Focal 1 (1%) 2 (2%) 1 (1%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (3) (2) (1) (2) Necrosis 1 (33%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (100) (100) (100) (100) (100) Atrophy 1 (1%) Granuloma Sperm 2 (2%) 3 (3%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Inflammation, Acute 1 (1%) Inflammation, Chronic 3 (3%) 4 (4%) 4 (4%) 5 (5%) 2 (2%) Inflammation, Chronic Active 1 (1%) 1 (1%) 1 (1%) 1 (1%) Inflammation, Granulomatous 1 (1%) Artery, Inflammation, Chronic 1 (1%) Bilateral, Inflammation, Acute 1 (1%) Bilateral, Inflammation, Chronic 1 (1%) Bilateral, Epithelium, Degeneration, Mucoid 58 (58%) 61 (61%) 54 (54%) 60 (60%) 54 (54%) Epithelium, Degeneration, Mucoid 24 (24%) 15 (15%) 29 (29%) 12 (12%) 25 (25%) Preputial Gland (100) (99) (100) (99) (100) Cyst 1 (1%) Hyperplasia, Focal 4 (4%) 8 (8%) 2 (2%) 4 (4%) 1 (1%) Inflammation, Acute 1 (1%) 1 (1%) Inflammation, Chronic 18 (18%) 19 (19%) 25 (25%) 31 (31%) 35 (35%) Inflammation, Chronic Active 4 (4%) 3 (3%) 2 (2%) 7 (7%) 4 (4%) Inflammation, Granulomatous 1 (1%) Bilateral, Atrophy 1 (1%) 1 (1%) 2 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 16 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Bilateral, Inflammation, Chronic 47 (47%) 48 (48%) 44 (44%) 33 (33%) 34 (34%) Bilateral, Inflammation, Chronic Active 11 (11%) 6 (6%) 5 (5%) 4 (4%) 11 (11%) Prostate (100) (99) (100) (99) (100) Atrophy 48 (48%) 57 (58%) 34 (34%) 47 (47%) 52 (52%) Cyst 1 (1%) Hypertrophy 1 (1%) Infiltration Cellular, Lymphocyte 2 (2%) Inflammation, Acute 4 (4%) 7 (7%) 15 (15%) 7 (7%) 14 (14%) Inflammation, Chronic 6 (6%) 6 (6%) 14 (14%) 6 (6%) 7 (7%) Inflammation, Chronic Active 36 (36%) 44 (44%) 36 (36%) 35 (35%) 39 (39%) Artery, Inflammation, Chronic 1 (1%) Bilateral, Inflammation, Chronic 1 (1%) Bilateral, Inflammation, Chronic Active 1 (1%) Epithelium, Hyperplasia, Focal 10 (10%) 7 (7%) 5 (5%) 9 (9%) 12 (12%) Seminal Vesicle (100) (99) (100) (99) (100) Atrophy 30 (30%) 48 (48%) 50 (50%) 38 (38%) 30 (30%) Dilatation 2 (2%) Inflammation, Acute 1 (1%) 1 (1%) Inflammation, Chronic Active 1 (1%) 1 (1%) Bilateral, Atrophy 54 (54%) 31 (31%) 36 (36%) 40 (40%) 49 (49%) Bilateral, Dilatation 1 (1%) 2 (2%) Testes (100) (100) (100) (100) (100) Mineralization 1 (1%) 1 (1%) 4 (4%) 1 (1%) Necrosis 1 (1%) Bilateral, Inflammation, Chronic 1 (1%) Bilateral, Mineralization 2 (2%) Bilateral, Necrosis 1 (1%) Bilateral, Artery, Inflammation, Chronic 1 (1%) Bilateral, Interstitial Cell, Hyperplasia, Diffuse 1 (1%) Bilateral, Interstitial Cell, Hyperplasia, Focal 3 (3%) 1 (1%) 5 (5%) 5 (5%) 3 (3%) Bilateral, Germinal Epithelium, Atrophy 4 (4%) 3 (3%) 3 (3%) 2 (2%) 4 (4%) Germinal Epithelium, Atrophy 6 (6%) 11 (11%) 11 (11%) 10 (10%) 9 (9%) Germinal Epithelium, Hyperplasia, Focal 1 (1%) Interstitial Cell, Hyperplasia, Focal 8 (8%) 8 (8%) 12 (12%) 17 (17%) 21 (21%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (100) (100) (100) (99) (100) Depletion Cellular 3 (3%) 2 (2%) 3 (3%) 2 (2%) 6 (6%) Hemorrhage 2 (2%) 1 (1%) Hyperplasia 14 (14%) 18 (18%) 15 (15%) 12 (12%) 12 (12%) Myelofibrosis 1 (1%) Necrosis 4 (4%) Lymph Node (15) (7) (7) (13) (8) a Number of animals examined microscopically at site and number of animals with lesion Page 17 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hyperplasia, Lymphoid 1 (7%) 1 (13%) Mediastinal, Hemorrhage 2 (13%) 1 (14%) 1 (14%) 2 (15%) 1 (13%) Mediastinal, Hyperplasia, Lymphoid 1 (14%) Mediastinal, Pigmentation 1 (7%) 1 (8%) Lymph Node, Mandibular (99) (99) (100) (100) (100) Atrophy 1 (1%) Degeneration, Cystic 15 (15%) 10 (10%) 11 (11%) 12 (12%) 11 (11%) Fibrosis 1 (1%) 1 (1%) Hemorrhage 2 (2%) 1 (1%) 7 (7%) 1 (1%) Hyperplasia, Lymphoid 17 (17%) 15 (15%) 14 (14%) 13 (13%) 14 (14%) Infiltration Cellular, Histiocyte 3 (3%) 4 (4%) 2 (2%) Pigmentation 1 (1%) 1 (1%) 1 (1%) 2 (2%) Lymph Node, Mesenteric (100) (99) (100) (100) (100) Angiectasis 1 (1%) Atrophy 1 (1%) 1 (1%) Degeneration, Cystic 1 (1%) 2 (2%) 2 (2%) 1 (1%) 1 (1%) Hematopoietic Cell Proliferation 1 (1%) Hemorrhage 2 (2%) 2 (2%) 2 (2%) 2 (2%) 1 (1%) Hyperplasia, Lymphoid 1 (1%) 1 (1%) 2 (2%) 3 (3%) Infiltration Cellular, Histiocyte 65 (65%) 70 (71%) 73 (73%) 70 (70%) 80 (80%) Inflammation, Chronic 2 (2%) Pigmentation 1 (1%) Artery, Inflammation, Chronic Active 1 (1%) Spleen (100) (100) (100) (100) (100) Accessory Spleen 1 (1%) 1 (1%) 1 (1%) Congestion 3 (3%) 5 (5%) 1 (1%) 1 (1%) Depletion Cellular, Focal 1 (1%) 1 (1%) Fibrosis 1 (1%) 6 (6%) 4 (4%) 1 (1%) 1 (1%) Hematopoietic Cell Proliferation 14 (14%) 12 (12%) 13 (13%) 15 (15%) 16 (16%) Hemorrhage 1 (1%) Necrosis, Focal 1 (1%) Pigmentation 12 (12%) 11 (11%) 17 (17%) 15 (15%) 19 (19%) Capsule, Inflammation, Chronic 3 (3%) 1 (1%) Capsule, Pigmentation, Focal 1 (1%) Lymphoid Follicle, Atrophy 1 (1%) 4 (4%) 3 (3%) 3 (3%) 3 (3%) Lymphoid Follicle, Hyperplasia 1 (1%) Thymus (97) (94) (95) (90) (95) Atrophy 58 (60%) 46 (49%) 63 (66%) 62 (69%) 44 (46%) Cyst 1 (1%) 2 (2%) 1 (1%) 2 (2%) Hemorrhage 2 (2%) 3 (3%) 2 (2%) 2 (2%) Hyperplasia, Lymphoid 1 (1%) 1 (1%) 1 (1%) Epithelial Cell, Hyperplasia 2 (2%) 3 (3%) 3 (3%) 6 (7%) 2 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 18 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (99) (97) (100) (98) (95) Cyst 18 (18%) 15 (15%) 10 (10%) 14 (14%) 14 (15%) Fibrosis 2 (2%) 1 (1%) 2 (2%) Galactocele 2 (2%) 5 (5%) 1 (1%) 5 (5%) Inflammation, Chronic 1 (1%) 3 (3%) 1 (1%) 1 (1%) Inflammation, Chronic Active 1 (1%) Mineralization 2 (2%) 1 (1%) 1 (1%) 1 (1%) Pigmentation 2 (2%) 4 (4%) Epithelium, Hyperplasia 9 (9%) 1 (1%) 4 (4%) 3 (3%) 4 (4%) Skin (99) (100) (100) (100) (100) Congestion 1 (1%) Cyst Epithelial Inclusion 4 (4%) 3 (3%) 3 (3%) 3 (3%) Hyperkeratosis 1 (1%) Inflammation, Acute 1 (1%) Inflammation, Chronic Active 1 (1%) Dermis, Fibrosis, Focal 2 (2%) 1 (1%) Epidermis, Hyperplasia 1 (1%) Hair Follicle, Hyperplasia, Focal 1 (1%) 1 (1%) Lip, Hemorrhage 1 (1%) Subcutaneous Tissue, Fibrosis 2 (2%) 1 (1%) Subcutaneous Tissue, Hemorrhage 1 (1%) Subcutaneous Tissue, Inflammation, Chronic 1 (1%) Subcutaneous Tissue, Necrosis 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (100) (100) (100) (100) (100) Cranium, Hyperostosis 1 (1%) 1 (1%) 1 (1%) 1 (1%) Femur, Hyperostosis 1 (1%) 2 (2%) 5 (5%) 2 (2%) 1 (1%) Femur, Hypertrophy 1 (1%) Maxilla, Osteomalacia 1 (1%) Turbinate, Hyperostosis 1 (1%) Skeletal Muscle (10) (6) (11) (4) (7) Infiltration Cellular, Lymphocyte 1 (17%) Inflammation, Chronic, Focal 1 (14%) Mineralization 1 (17%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (100) (100) (100) (100) (100) Artery, Thrombosis 1 (1%) Cerebrum, Hemorrhage 1 (1%) Cerebrum, Hydrocephalus 1 (1%) Cerebrum, Infiltration Cellular, Lymphocyte 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 19 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - CONT Cerebrum, Necrosis 2 (2%) 1 (1%) Choroid Plexus, Hyperplasia 1 (1%) Choroid Plexus, Mineralization 1 (1%) 1 (1%) Choroid Plexus, Cerebrum, Infiltration Cellular, Lymphocyte 1 (1%) Hypothalamus, Compression 5 (5%) 8 (8%) 1 (1%) 9 (9%) 8 (8%) Hypothalamus, Necrosis, Focal 1 (1%) Meninges, Hyperplasia 1 (1%) Pons, Compression 1 (1%) Thalamus, Necrosis, Focal 1 (1%) Spinal Cord (11) (6) (9) (4) (6) Meninges, Cyst Epithelial Inclusion 1 (9%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (100) (100) (100) (100) (100) Congestion 5 (5%) 5 (5%) 2 (2%) 4 (4%) 3 (3%) Edema 1 (1%) Fibrosis, Focal 1 (1%) Foreign Body 1 (1%) Hemorrhage 1 (1%) Infiltration Cellular, Lymphocyte 11 (11%) 5 (5%) 2 (2%) 3 (3%) Infiltration Cellular, Histiocyte 8 (8%) 18 (18%) 12 (12%) 6 (6%) 5 (5%) Inflammation, Acute 1 (1%) Inflammation, Chronic, Focal 1 (1%) Metaplasia, Focal, Osseous 1 (1%) 4 (4%) 1 (1%) Alveolar Epithelium, Hyperplasia, Focal 6 (6%) 3 (3%) 7 (7%) 5 (5%) 4 (4%) Artery, Inflammation, Chronic 1 (1%) Bronchus, Inflammation, Acute 1 (1%) 1 (1%) Bronchus, Inflammation, Chronic 2 (2%) Bronchus, Inflammation, Chronic Active 1 (1%) Interstitium, Inflammation, Acute 1 (1%) Interstitium, Inflammation, Chronic 5 (5%) 5 (5%) 3 (3%) 2 (2%) 3 (3%) Interstitium, Inflammation, Chronic Active 1 (1%) 2 (2%) Serosa, Inflammation, Chronic 1 (1%) Nose (100) (98) (100) (100) (100) Congestion 1 (1%) Foreign Body 1 (1%) 1 (1%) 1 (1%) 1 (1%) Inflammation, Acute 1 (1%) 2 (2%) Inflammation, Chronic 5 (5%) 3 (3%) 5 (5%) 4 (4%) 3 (3%) Inflammation, Chronic Active 22 (22%) 25 (26%) 35 (35%) 25 (25%) 31 (31%) Metaplasia, Squamous 2 (2%) Mineralization, Focal 1 (1%) Glands, Cyst 1 (1%) Nasolacrimal Duct, Inflammation, Acute 1 (1%) 1 (1%) 1 (1%) Nasolacrimal Duct, Inflammation, Chronic 6 (6%) 8 (8%) 12 (12%) 7 (7%) 4 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 20 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Nasolacrimal Duct, Inflammation, Chronic Active 1 (1%) 1 (1%) 3 (3%) 4 (4%) Olfactory Epithelium, Cyst 1 (1%) Olfactory Epithelium, Cytoplasmic Alteration 36 (36%) 32 (33%) 48 (48%) 41 (41%) 29 (29%) Olfactory Epithelium, Mineralization 1 (1%) Respiratory Epithelium, Cyst 1 (1%) 1 (1%) Respiratory Epithelium, Cytoplasmic Alteration 3 (3%) 1 (1%) 1 (1%) 1 (1%) Respiratory Epithelium, Hyperplasia, Focal 1 (1%) Trachea (100) (100) (100) (100) (100) Inflammation, Chronic 10 (10%) 12 (12%) 15 (15%) 3 (3%) 12 (12%) Inflammation, Chronic Active 1 (1%) 1 (1%) Glands, Cyst 1 (1%) 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (2) (7) (1) Bilateral, Lens, Cataract 1 (14%) Bilateral, Retina, Atrophy 3 (43%) Iris, Inflammation, Chronic 1 (50%) Iris, Synechia 1 (14%) 1 (100%) Lens, Cataract 3 (100%) 1 (50%) 5 (71%) 1 (100%) Retina, Atrophy 3 (100%) 2 (100%) 4 (57%) 1 (100%) Harderian Gland (100) (100) (100) (100) (100) Atrophy, Diffuse 1 (1%) Atrophy, Focal 2 (2%) 1 (1%) 8 (8%) 2 (2%) 1 (1%) Hyperplasia, Focal 2 (2%) 2 (2%) 4 (4%) 2 (2%) Infiltration Cellular, Lymphocyte 26 (26%) 30 (30%) 23 (23%) 25 (25%) 44 (44%) Inflammation, Acute 1 (1%) Inflammation, Chronic 3 (3%) 4 (4%) 6 (6%) 2 (2%) 1 (1%) Inflammation, Chronic Active 1 (1%) Pigmentation 1 (1%) Bilateral, Atrophy, Diffuse 1 (1%) Bilateral, Atrophy, Focal 1 (1%) Bilateral, Infiltration Cellular, Lymphocyte 17 (17%) 19 (19%) 21 (21%) 21 (21%) 16 (16%) Bilateral, Inflammation, Chronic 5 (5%) 8 (8%) 5 (5%) 2 (2%) 5 (5%) Bilateral, Inflammation, Chronic Active 1 (1%) 1 (1%) Bilateral, Pigmentation 1 (1%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (100) (100) (100) (100) (100) Cyst 1 (1%) 3 (3%) 1 (1%) 2 (2%) 1 (1%) Fibrosis, Focal 2 (2%) Infarct 1 (1%) 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 21 NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98 Route: MAGNETIC FIELDS Time: 16:24:10 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS CONTROL GAUSS INTER ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Mineralization 16 (16%) 18 (18%) 14 (14%) 17 (17%) 16 (16%) Nephropathy 1 (1%) 1 (1%) 2 (2%) 1 (1%) 2 (2%) Artery, Inflammation, Chronic 1 (1%) Bilateral, Hydronephrosis 1 (1%) Bilateral, Mineralization 23 (23%) 10 (10%) 19 (19%) 14 (14%) 25 (25%) Bilateral, Nephropathy 91 (91%) 84 (84%) 87 (87%) 85 (85%) 87 (87%) Bilateral, Pigmentation 2 (2%) 1 (1%) Bilateral, Artery, Mineralization 1 (1%) Bilateral, Papilla, Necrosis 1 (1%) 1 (1%) Bilateral, Pelvis, Inflammation, Acute 1 (1%) Bilateral, Pelvis, Inflammation, Chronic 1 (1%) Bilateral, Pelvis, Inflammation, Chronic Active 1 (1%) Bilateral, Renal Tubule, Crystals 1 (1%) Bilateral, Renal Tubule, Degeneration 2 (2%) 2 (2%) 2 (2%) 1 (1%) Bilateral, Renal Tubule, Pigmentation 29 (29%) 20 (20%) 26 (26%) 23 (23%) 35 (35%) Papilla, Necrosis 1 (1%) Pelvis, Inflammation, Acute 1 (1%) Pelvis, Inflammation, Chronic 1 (1%) Pelvis, Transitional Epithelium, Hyperplasia 2 (2%) 1 (1%) Renal Tubule, Hyperplasia, Focal 1 (1%) 1 (1%) Urinary Bladder (99) (96) (100) (100) (99) Edema 2 (2%) 1 (1%) Hemorrhage 1 (1%) Infiltration Cellular, Lymphocyte 4 (4%) 6 (6%) 3 (3%) 6 (6%) 7 (7%) Inflammation, Acute 3 (3%) Inflammation, Chronic 2 (2%) 1 (1%) 1 (1%) Ulcer 1 (1%) Transitional Epithelium, Hyperplasia 1 (1%) 1 (1%) 2 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 22 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------