TDMS Study 89029-05 Pathology Tables
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
MERGED REPORTS FINAL #3
Facility: I. I. T. Research Institute
Chemical CAS #: ELECTROMAG
Lock Date: 09/04/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Merge 001 001,011 SHAM CONTROL
Merge 002 002,012 SHAM CONTROL
Merge 003 003,013 .02 GAUSS
Merge 004 004,014 .02 GAUSS
Merge 005 005,015 2 GAUSS
Merge 006 006,016 2 GAUSS
Merge 007 009,019 10 GAUSS
Merge 008 010,020 10 GAUSS
Merge 009 007,017 10 GAUSS INTER
Merge 010 008,018 10 GAUSS INTER
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 100 100 100 100 100
Early Deaths
Natural Death 18 17 18 19 19
Moribund Sacrifice 22 15 22 18 23
Survivors
Terminal Sacrifice 58 66 60 59 58
Natural Death 1 1
Moribund Sacrifice 1 1 1
Other 1 2
Animals Examined Microscopically 100 100 100 100 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (100) (100) (100) (100) (97)
Inflammation, Chronic Active 1 (1%)
Intestine Large, Rectum (99) (100) (100) (99) (100)
Inflammation, Chronic 1 (1%)
Inflammation, Chronic Active 1 (1%)
Intestine Large, Cecum (100) (98) (99) (100) (96)
Epithelium, Hyperplasia 1 (1%)
Intestine Small, Duodenum (97) (97) (96) (100) (96)
Diverticulum 1 (1%)
Ectopic Tissue 1 (1%) 1 (1%)
Intestine Small, Ileum (94) (91) (93) (97) (91)
Ulcer 1 (1%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (2%)
Serosa, Inflammation, Chronic 1 (1%)
Liver (100) (100) (100) (100) (100)
Angiectasis, Focal 1 (1%) 1 (1%) 2 (2%) 3 (3%)
Basophilic Focus 66 (66%) 82 (82%) 77 (77%) 66 (66%) 78 (78%)
Clear Cell Focus 6 (6%) 13 (13%) 18 (18%) 13 (13%) 18 (18%)
Congestion 1 (1%)
Eosinophilic Focus 18 (18%) 24 (24%) 30 (30%) 24 (24%) 31 (31%)
Fibrosis 2 (2%) 1 (1%) 1 (1%) 1 (1%)
Hematopoietic Cell Proliferation 6 (6%) 3 (3%) 2 (2%) 4 (4%) 2 (2%)
Hepatodiaphragmatic Nodule 8 (8%) 4 (4%) 4 (4%) 5 (5%) 6 (6%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) 4 (4%) 2 (2%)
Infiltration Cellular, Histiocyte 2 (2%) 1 (1%)
Infiltration Cellular, Mixed Cell 32 (32%) 40 (40%) 37 (37%) 28 (28%) 27 (27%)
Inflammation, Chronic 1 (1%) 1 (1%) 2 (2%) 2 (2%) 2 (2%)
Inflammation, Chronic Active 1 (1%)
Inflammation, Granulomatous 2 (2%)
Mixed Cell Focus 39 (39%) 45 (45%) 49 (49%) 42 (42%) 37 (37%)
Necrosis 3 (3%) 4 (4%) 7 (7%) 4 (4%) 4 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pigmentation 1 (1%)
Tension Lipidosis, Focal 1 (1%) 1 (1%) 1 (1%)
Bile Duct, Hyperplasia 28 (28%) 20 (20%) 31 (31%) 21 (21%) 24 (24%)
Hepatocyte, Hypertrophy 1 (1%)
Hepatocyte, Vacuolization Cytoplasmic 11 (11%) 12 (12%) 9 (9%) 11 (11%) 9 (9%)
Mesentery (11) (6) (5) (13) (16)
Accessory Spleen 1 (9%) 1 (8%)
Fat, Necrosis 9 (82%) 4 (67%) 4 (80%) 10 (77%) 15 (94%)
Pancreas (100) (100) (99) (100) (99)
Infiltration Cellular, Lymphocyte 14 (14%) 10 (10%) 9 (9%) 9 (9%) 7 (7%)
Metaplasia, Hepatocyte 2 (2%)
Acinus, Atrophy, Diffuse 3 (3%) 1 (1%) 2 (2%)
Acinus, Atrophy, Focal 15 (15%) 18 (18%) 26 (26%) 16 (16%) 20 (20%)
Acinus, Basophilic Focus 2 (2%)
Acinus, Hyperplasia, Focal 3 (3%) 5 (5%) 5 (5%) 1 (1%) 2 (2%)
Artery, Inflammation, Chronic 1 (1%)
Duct, Hyperplasia 1 (1%) 1 (1%)
Salivary Glands (100) (99) (100) (100) (100)
Pigmentation 1 (1%)
Duct, Parotid Gland, Hyperplasia 1 (1%)
Duct, Parotid Gland, Mineralization 1 (1%)
Duct, Sublingual Gland, Metaplasia, Squamous 1 (1%) 2 (2%)
Parotid Gland, Atrophy 3 (3%) 2 (2%) 3 (3%) 2 (2%) 2 (2%)
Parotid Gland, Hyperplasia 1 (1%) 1 (1%)
Parotid Gland, Inflammation, Acute 1 (1%)
Parotid Gland, Inflammation, Chronic 1 (1%)
Sublingual Gland, Atrophy 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Sublingual Gland, Infiltration Cellular,
Lymphocyte 1 (1%)
Sublingual Gland, Metaplasia, Squamous 1 (1%)
Submandibular Gland, Infiltration Cellular,
Lymphocyte 1 (1%)
Stomach, Forestomach (100) (99) (99) (100) (100)
Edema 3 (3%) 1 (1%) 3 (3%)
Erosion, Focal 1 (1%)
Inflammation, Acute 1 (1%) 1 (1%) 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%)
Inflammation, Chronic Active 1 (1%) 2 (2%)
Ulcer 3 (3%) 1 (1%) 3 (3%) 1 (1%)
Epithelium, Hyperplasia 7 (7%) 2 (2%) 3 (3%) 10 (10%)
Stomach, Glandular (100) (100) (99) (100) (100)
Edema 1 (1%) 1 (1%)
Erosion, Focal 5 (5%) 2 (2%) 2 (2%) 5 (5%) 3 (3%)
Fibrosis 1 (1%)
Inflammation, Chronic Active 1 (1%)
Metaplasia, Focal, Squamous 1 (1%)
Necrosis, Focal 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Glands, Congestion 1 (1%)
Glands, Cyst 12 (12%) 20 (20%) 26 (26%) 12 (12%) 12 (12%)
Muscularis, Mineralization 1 (1%)
Tongue (1) (1) (2) (1)
Epithelium, Hyperplasia, Focal 1 (100%) 1 (100%) 1 (50%) 1 (100%)
Tooth (2) (1) (1) (1) (1)
Inflammation, Chronic 1 (100%)
Malformation 1 (50%) 1 (100%)
Necrosis 1 (100%)
Gingiva, Inflammation, Chronic Active 1 (100%)
Peridontal Tissue, Inflammation, Chronic
Active 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (99) (100) (100) (100) (100)
Inflammation, Chronic 1 (1%)
Heart (100) (100) (100) (100) (100)
Cardiomyopathy 53 (53%) 71 (71%) 64 (64%) 61 (61%) 60 (60%)
Artery, Inflammation, Chronic 1 (1%)
Atrium, Mineralization 1 (1%)
Atrium, Thrombosis 1 (1%) 2 (2%)
Endocardium, Inflammation, Chronic 1 (1%)
Myocardium, Fibrosis, Focal 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (100) (100) (100) (100) (100)
Angiectasis 1 (1%) 4 (4%) 4 (4%) 1 (1%) 5 (5%)
Degeneration 1 (1%) 1 (1%)
Hematopoietic Cell Proliferation 1 (1%) 2 (2%) 4 (4%) 2 (2%)
Hemorrhage 1 (1%)
Hyperplasia, Focal 11 (11%) 23 (23%) 12 (12%) 8 (8%) 15 (15%)
Hypertrophy, Focal 3 (3%) 1 (1%) 5 (5%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%)
Inflammation, Chronic 1 (1%)
Mineralization 1 (1%) 1 (1%)
Necrosis 1 (1%) 2 (2%) 1 (1%) 1 (1%)
Vacuolization Cytoplasmic, Diffuse 1 (1%) 2 (2%) 1 (1%)
Vacuolization Cytoplasmic, Focal 27 (27%) 27 (27%) 24 (24%) 31 (31%) 24 (24%)
Bilateral, Angiectasis 57 (57%) 51 (51%) 46 (46%) 58 (58%) 57 (57%)
Bilateral, Hematopoietic Cell Proliferation 2 (2%) 3 (3%) 4 (4%) 2 (2%)
Bilateral, Hyperplasia, Focal 1 (1%) 2 (2%) 1 (1%)
Bilateral, Infiltration Cellular, Lymphocyte 1 (1%)
Bilateral, Infiltration Cellular, Mixed Cell 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Bilateral, Inflammation, Chronic 1 (1%) 1 (1%)
Bilateral, Necrosis 1 (1%) 1 (1%)
Bilateral, Pigmentation 2 (2%) 2 (2%)
Bilateral, Vacuolization Cytoplasmic, Diffuse 1 (1%)
Bilateral, Vacuolization Cytoplasmic, Focal 2 (2%) 3 (3%) 2 (2%) 3 (3%) 3 (3%)
Adrenal Medulla (96) (94) (94) (98) (97)
Hyperplasia, Focal 6 (6%) 6 (6%) 4 (4%) 7 (7%) 4 (4%)
Bilateral, Hyperplasia, Focal 1 (1%)
Bilateral, Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Bilateral, Necrosis 1 (1%)
Islets, Pancreatic (100) (100) (99) (100) (99)
Hyperplasia, Focal 1 (1%) 1 (1%)
Parathyroid Gland (88) (94) (91) (88) (92)
Cyst 1 (1%) 1 (1%)
Degeneration 1 (1%)
Hyperplasia, Focal 1 (1%)
Pineal Gland (85) (90) (85) (90) (89)
Fibrosis 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%)
Mineralization 56 (66%) 54 (60%) 57 (67%) 54 (60%) 40 (45%)
Pituitary Gland (99) (99) (98) (98) (98)
Pars Distalis, Angiectasis 1 (1%) 1 (1%)
Pars Distalis, Angiectasis, Focal 1 (1%) 9 (9%) 5 (5%) 3 (3%) 2 (2%)
Pars Distalis, Cyst 21 (21%) 21 (21%) 19 (19%) 28 (29%) 25 (26%)
Pars Distalis, Degeneration, Focal 1 (1%)
Pars Distalis, Hyperplasia, Diffuse 1 (1%)
Pars Distalis, Hyperplasia, Focal 10 (10%) 9 (9%) 6 (6%) 6 (6%) 7 (7%)
Pars Distalis, Hypertrophy, Focal 1 (1%) 1 (1%)
Pars Distalis, Inflammation, Chronic 2 (2%) 1 (1%) 1 (1%)
Pars Distalis, Pigmentation 2 (2%) 1 (1%) 2 (2%) 1 (1%)
Pars Intermedia, Hyperplasia, Focal 1 (1%) 1 (1%) 1 (1%)
Rathke's Cleft, Cyst 2 (2%) 2 (2%)
Rathke's Cleft, Hemorrhage 1 (1%)
Rathke's Cleft, Pigmentation 1 (1%) 1 (1%) 1 (1%)
Thyroid Gland (100) (100) (100) (100) (100)
Infiltration Cellular, Lymphocyte 1 (1%)
Ultimobranchial Cyst 2 (2%) 4 (4%) 7 (7%) 3 (3%) 3 (3%)
C-Cell, Hyperplasia 18 (18%) 5 (5%)
C-Cell, Hyperplasia, Diffuse 2 (2%) 1 (1%) 3 (3%) 2 (2%)
C-Cell, Hyperplasia, Focal 20 (20%) 39 (39%) 52 (52%) 24 (24%) 30 (30%)
Follicle, Cyst 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Follicular Cell, Hyperplasia, Focal 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (90) (96) (97) (96) (94)
Cyst 1 (1%) 7 (7%) 1 (1%) 3 (3%)
Hyperplasia, Focal 6 (7%) 4 (4%) 3 (3%) 5 (5%) 5 (5%)
Inflammation, Acute 1 (1%) 1 (1%)
Inflammation, Chronic 15 (17%) 9 (9%) 13 (13%) 23 (24%) 12 (13%)
Inflammation, Chronic Active 7 (7%) 2 (2%) 5 (5%) 1 (1%)
Bilateral, Atrophy 1 (1%)
Bilateral, Inflammation, Chronic 8 (9%) 2 (2%) 4 (4%) 2 (2%) 7 (7%)
Bilateral, Inflammation, Chronic Active 2 (2%) 2 (2%)
Ovary (100) (100) (100) (100) (99)
Inflammation, Chronic 1 (1%) 1 (1%) 1 (1%) 2 (2%)
Mineralization 1 (1%)
Bilateral, Atrophy 1 (1%) 2 (2%) 1 (1%)
Bilateral, Inflammation, Chronic 3 (3%) 2 (2%) 3 (3%) 1 (1%) 2 (2%)
Bilateral, Pigmentation 2 (2%)
Bilateral, Periovarian Tissue, Cyst 2 (2%)
Bilateral, Follicle, Cyst 1 (1%)
Bilateral, Rete Ovarii, Hyperplasia 3 (3%) 2 (2%) 3 (3%) 1 (1%) 3 (3%)
Follicle, Cyst 3 (3%) 5 (5%) 1 (1%) 4 (4%) 2 (2%)
Interstitial Cell, Hyperplasia 1 (1%)
Periovarian Tissue, Cyst 6 (6%) 6 (6%) 12 (12%) 8 (8%) 11 (11%)
Rete Ovarii, Hyperplasia 5 (5%) 14 (14%) 5 (5%) 14 (14%) 13 (13%)
Uterus (100) (100) (100) (100) (99)
Hemorrhage 1 (1%) 2 (2%)
Hydrometra 9 (9%) 10 (10%) 8 (8%) 7 (7%) 6 (6%)
Pigmentation 2 (2%) 1 (1%) 1 (1%) 1 (1%)
Cervix, Cyst 2 (2%)
Cervix, Inflammation, Chronic Active 2 (2%) 1 (1%) 1 (1%) 1 (1%)
Cervix, Epithelium, Vacuolization Cytoplasmic 1 (1%)
Endometrium, Angiectasis, Focal 1 (1%)
Endometrium, Cyst 3 (3%) 3 (3%) 4 (4%) 1 (1%) 9 (9%)
Endometrium, Cytoplasmic Alteration 1 (1%)
Endometrium, Fibrosis 1 (1%) 1 (1%) 2 (2%)
Endometrium, Hyperplasia 1 (1%)
Endometrium, Inflammation, Acute 1 (1%)
Endometrium, Inflammation, Chronic 1 (1%) 3 (3%) 3 (3%) 1 (1%)
Endometrium, Inflammation, Chronic Active 2 (2%)
Endometrium, Pigmentation 2 (2%) 1 (1%)
Endometrium, Epithelium, Hyperplasia 1 (1%) 1 (1%)
Serosa, Fibrosis 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Vagina (1) (1) (2) (2)
Cyst 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (100) (100) (100) (100) (100)
Depletion Cellular 9 (9%) 5 (5%) 6 (6%) 4 (4%) 11 (11%)
Hyperplasia 13 (13%) 19 (19%) 13 (13%) 12 (12%) 17 (17%)
Inflammation, Chronic 1 (1%)
Myelofibrosis 1 (1%) 1 (1%)
Lymph Node (16) (5) (5) (10) (18)
Pigmentation 2 (13%)
Inguinal, Degeneration, Cystic 1 (20%)
Inguinal, Hyperplasia, Lymphoid 1 (6%) 1 (20%)
Mediastinal, Hemorrhage 1 (6%) 1 (20%) 1 (10%) 3 (17%)
Mediastinal, Pigmentation 1 (6%) 1 (20%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (20%)
Lymph Node, Mandibular (100) (99) (100) (100) (100)
Atrophy 1 (1%)
Congestion 2 (2%)
Degeneration, Cystic 11 (11%) 19 (19%) 4 (4%) 8 (8%) 15 (15%)
Hemorrhage 1 (1%) 2 (2%) 3 (3%) 2 (2%) 3 (3%)
Hyperplasia, Lymphoid 13 (13%) 21 (21%) 11 (11%) 7 (7%) 7 (7%)
Infiltration Cellular, Histiocyte 3 (3%) 1 (1%) 2 (2%) 1 (1%)
Pigmentation 2 (2%) 2 (2%) 3 (3%)
Lymph Node, Mesenteric (100) (99) (99) (99) (99)
Angiectasis 1 (1%)
Degeneration, Cystic 2 (2%) 1 (1%) 1 (1%)
Hemorrhage 3 (3%) 3 (3%) 2 (2%) 4 (4%) 4 (4%)
Hyperplasia, Lymphoid 1 (1%) 2 (2%)
Infiltration Cellular, Histiocyte 85 (85%) 92 (93%) 86 (87%) 87 (88%) 86 (87%)
Spleen (100) (100) (100) (100) (99)
Congestion 1 (1%) 1 (1%)
Depletion Cellular, Focal 1 (1%) 1 (1%) 2 (2%)
Fibrosis 1 (1%) 2 (2%)
Hematopoietic Cell Proliferation 15 (15%) 15 (15%) 20 (20%) 13 (13%) 28 (28%)
Infiltration Cellular, Histiocyte 2 (2%)
Pigmentation 54 (54%) 48 (48%) 56 (56%) 57 (57%) 46 (46%)
Capsule, Fibrosis 1 (1%)
Lymphoid Follicle, Atrophy 6 (6%) 3 (3%) 3 (3%) 4 (4%) 6 (6%)
Lymphoid Follicle, Hyperplasia 1 (1%) 1 (1%)
Thymus (95) (95) (92) (91) (92)
Atrophy 51 (54%) 48 (51%) 47 (51%) 48 (53%) 43 (47%)
Cyst 1 (1%) 3 (3%) 5 (5%) 2 (2%) 2 (2%)
Ectopic Parathyroid Gland 1 (1%)
Hemorrhage 2 (2%) 1 (1%) 3 (3%) 6 (7%) 5 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (1%)
Epithelial Cell, Hyperplasia 3 (3%) 1 (1%) 3 (3%) 4 (4%) 2 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (100) (100) (100) (100) (100)
Cyst 47 (47%) 54 (54%) 56 (56%) 61 (61%) 53 (53%)
Fibrosis 2 (2%)
Galactocele 10 (10%) 7 (7%) 14 (14%) 7 (7%) 10 (10%)
Inflammation, Chronic 1 (1%) 2 (2%) 2 (2%) 2 (2%)
Mineralization 2 (2%)
Epithelium, Hyperplasia 1 (1%) 4 (4%) 3 (3%) 2 (2%) 3 (3%)
Skin (100) (100) (100) (100) (100)
Cyst Epithelial Inclusion 1 (1%) 1 (1%)
Hyperkeratosis 1 (1%) 1 (1%)
Hyperkeratosis, Focal 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%) 1 (1%)
Inflammation, Chronic Active 1 (1%) 1 (1%)
Inflammation, Chronic Active, Focal 1 (1%)
Dermis, Fibrosis, Focal 1 (1%)
Epidermis, Hyperplasia, Diffuse 1 (1%)
Epidermis, Lip, Hyperplasia, Focal 1 (1%)
Nipple, Hyperkeratosis 1 (1%)
Subcutaneous Tissue, Inflammation, Chronic 1 (1%)
Subcutaneous Tissue, Necrosis 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (100) (100) (100) (100) (100)
Cranium, Hyperostosis 7 (7%) 1 (1%) 5 (5%) 5 (5%) 2 (2%)
Femur, Hyperostosis 20 (20%) 10 (10%) 20 (20%) 18 (18%) 13 (13%)
Intervertebral Disc, Degeneration 1 (1%)
Maxilla, Hyperostosis 1 (1%) 1 (1%)
Turbinate, Hyperostosis 7 (7%) 3 (3%) 9 (9%) 11 (11%) 6 (6%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (100) (100) (100) (100)
Mineralization 1 (1%)
Cerebellum, Gliosis, Focal 1 (1%)
Cerebellum, Hemorrhage 2 (2%)
Cerebrum, Infiltration Cellular, Lymphocyte 1 (1%)
Cerebrum, Mineralization 2 (2%)
Hypothalamus, Compression 16 (16%) 9 (9%) 16 (16%) 15 (15%) 19 (19%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Pons, Compression 2 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (1) (1) (1) (1) (1)
Inflammation, Chronic 1 (100%)
Lung (100) (100) (100) (100) (100)
Congestion 5 (5%) 7 (7%) 4 (4%) 6 (6%) 7 (7%)
Emphysema 1 (1%)
Hemorrhage 1 (1%) 2 (2%) 1 (1%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%) 6 (6%) 4 (4%) 7 (7%) 3 (3%)
Infiltration Cellular, Histiocyte 31 (31%) 42 (42%) 34 (34%) 46 (46%) 35 (35%)
Infiltration Cellular, Mixed Cell 2 (2%) 5 (5%)
Metaplasia, Focal, Osseous 1 (1%)
Mineralization 1 (1%)
Pigmentation 1 (1%) 1 (1%) 1 (1%)
Alveolar Epithelium, Hyperplasia, Focal 4 (4%) 3 (3%) 4 (4%) 1 (1%) 3 (3%)
Interstitium, Inflammation, Chronic 10 (10%) 20 (20%) 13 (13%) 4 (4%) 7 (7%)
Serosa, Inflammation, Chronic 1 (1%) 1 (1%)
Nose (100) (100) (100) (100) (100)
Inflammation, Acute 1 (1%) 2 (2%)
Inflammation, Chronic 1 (1%) 2 (2%) 4 (4%) 1 (1%) 3 (3%)
Inflammation, Chronic Active 8 (8%) 8 (8%) 7 (7%) 5 (5%) 7 (7%)
Glands, Cyst 1 (1%)
Nasolacrimal Duct, Inflammation, Acute 1 (1%) 2 (2%)
Nasolacrimal Duct, Inflammation, Chronic 2 (2%) 6 (6%) 4 (4%) 1 (1%) 7 (7%)
Nasolacrimal Duct, Inflammation, Chronic
Active 3 (3%) 2 (2%) 1 (1%)
Olfactory Epithelium, Cytoplasmic Alteration 69 (69%) 83 (83%) 87 (87%) 74 (74%) 77 (77%)
Olfactory Epithelium, Mineralization, Focal 1 (1%)
Respiratory Epithelium, Cytoplasmic
Alteration 4 (4%) 1 (1%) 3 (3%) 5 (5%) 1 (1%)
Trachea (100) (100) (100) (100) (100)
Inflammation, Chronic 6 (6%) 1 (1%) 7 (7%) 7 (7%) 5 (5%)
Inflammation, Chronic Active 1 (1%)
Glands, Cyst 2 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (4) (7) (6) (3)
Atrophy 2 (29%) 1 (17%)
Bilateral, Cornea, Mineralization 1 (33%)
Bilateral, Iris, Synechia 1 (17%)
Bilateral, Lens, Cataract 1 (17%) 1 (14%) 1 (17%)
Bilateral, Retina, Atrophy 1 (17%) 1 (14%) 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Cornea, Inflammation, Acute 1 (14%)
Cornea, Inflammation, Chronic Active 1 (17%)
Iris, Synechia 1 (17%)
Lens, Cataract 5 (83%) 4 (100%) 4 (57%) 3 (50%) 2 (67%)
Retina, Atrophy 5 (83%) 4 (100%) 4 (57%) 3 (50%) 2 (67%)
Harderian Gland (100) (100) (100) (100) (100)
Atrophy, Focal 1 (1%) 2 (2%) 2 (2%) 3 (3%)
Cyst 1 (1%)
Hyperplasia, Focal 1 (1%) 2 (2%) 2 (2%)
Infiltration Cellular, Lymphocyte 34 (34%) 33 (33%) 33 (33%) 28 (28%) 27 (27%)
Inflammation, Chronic 4 (4%) 3 (3%) 5 (5%) 6 (6%) 2 (2%)
Mineralization 1 (1%)
Pigmentation 1 (1%)
Bilateral, Infiltration Cellular, Lymphocyte 35 (35%) 40 (40%) 32 (32%) 28 (28%) 39 (39%)
Bilateral, Inflammation, Chronic 6 (6%) 6 (6%) 11 (11%) 9 (9%) 12 (12%)
Bilateral, Inflammation, Chronic Active 1 (1%)
Lacrimal Gland (2) (1) (1) (4)
Inflammation, Chronic 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (100) (100) (100) (100) (100)
Hydronephrosis 1 (1%)
Infarct 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Infiltration Cellular, Lymphocyte 2 (2%) 1 (1%)
Inflammation, Chronic Active 1 (1%)
Mineralization 13 (13%) 12 (12%) 18 (18%) 11 (11%) 23 (23%)
Bilateral, Infiltration Cellular, Lymphocyte 1 (1%)
Bilateral, Mineralization 10 (10%) 12 (12%) 11 (11%) 6 (6%) 16 (16%)
Bilateral, Necrosis, Chronic 1 (1%)
Bilateral, Nephropathy 54 (54%) 46 (46%) 69 (69%) 46 (46%) 51 (51%)
Bilateral, Pigmentation 2 (2%) 1 (1%)
Bilateral, Artery, Hypertrophy 1 (1%)
Bilateral, Medulla, Inflammation, Chronic 1 (1%)
Bilateral, Pelvis, Inflammation, Acute 1 (1%)
Bilateral, Pelvis, Inflammation, Chronic 2 (2%) 1 (1%)
Bilateral, Pelvis, Inflammation, Chronic
Active 1 (1%)
Bilateral, Pelvis, Transitional Epithelium,
Hyperplasia 2 (2%)
Bilateral, Renal Tubule, Accumulation,
Hyaline Droplet 5 (5%) 2 (2%) 3 (3%) 3 (3%)
Bilateral, Renal Tubule, Degeneration 2 (2%) 2 (2%) 1 (1%) 2 (2%) 3 (3%)
Bilateral, Renal Tubule, Dilatation 1 (1%)
Bilateral, Renal Tubule, Pigmentation 26 (26%) 11 (11%) 13 (13%) 30 (30%) 11 (11%)
Capsule, Fibrosis, Focal 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Pelvis, Dilatation 1 (1%) 1 (1%)
Pelvis, Inflammation, Acute 1 (1%)
Pelvis, Inflammation, Chronic 2 (2%) 1 (1%) 2 (2%)
Pelvis, Inflammation, Chronic Active 3 (3%) 1 (1%)
Pelvis, Transitional Epithelium, Hyperplasia 2 (2%) 1 (1%) 1 (1%) 1 (1%)
Renal Tubule, Hyperplasia, Focal 1 (1%) 1 (1%)
Renal Tubule, Necrosis 1 (1%)
Urinary Bladder (99) (97) (99) (99) (96)
Calculus Micro Observation Only 1 (1%)
Edema 1 (1%) 1 (1%)
Infiltration Cellular, Lymphocyte 10 (10%) 9 (9%) 9 (9%) 5 (5%) 10 (10%)
Inflammation, Chronic 1 (1%) 2 (2%) 1 (1%) 1 (1%)
Transitional Epithelium, Hyperplasia 2 (2%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 100 100 100 100 100
Early Deaths
Moribund Sacrifice 29 32 32 36 33
Natural Death 14 21 21 16 7
Survivors
Terminal Sacrifice 57 46 47 48 59
Other 1 1
Animals Examined Microscopically 100 100 100 100 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (100) (99) (99) (100) (99)
Inflammation, Chronic 1 (1%)
Parasite Metazoan 1 (1%)
Intestine Large, Rectum (99) (100) (100) (99) (100)
Edema 1 (1%)
Ulcer 1 (1%)
Intestine Large, Cecum (98) (99) (97) (100) (99)
Edema 1 (1%) 1 (1%) 1 (1%)
Inflammation, Chronic Active 1 (1%)
Parasite Metazoan 1 (1%)
Intestine Small, Duodenum (99) (94) (100) (100) (98)
Inflammation, Acute 1 (1%)
Intestine Small, Ileum (94) (92) (97) (96) (97)
Inflammation, Chronic 1 (1%) 1 (1%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (2%) 1 (1%)
Liver (100) (100) (100) (100) (100)
Angiectasis, Focal 1 (1%) 3 (3%) 1 (1%)
Atrophy 1 (1%)
Atypia Cellular, Focal 1 (1%)
Basophilic Focus 35 (35%) 35 (35%) 47 (47%) 37 (37%) 36 (36%)
Clear Cell Focus 44 (44%) 37 (37%) 38 (38%) 35 (35%) 41 (41%)
Degeneration, Cystic, Focal 8 (8%) 2 (2%) 11 (11%) 13 (13%) 5 (5%)
Eosinophilic Focus 21 (21%) 19 (19%) 26 (26%) 17 (17%) 17 (17%)
Hematopoietic Cell Proliferation 5 (5%) 4 (4%) 6 (6%) 3 (3%) 2 (2%)
Hepatodiaphragmatic Nodule 2 (2%) 5 (5%) 7 (7%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%) 2 (2%)
Infiltration Cellular, Mixed Cell 11 (11%) 15 (15%) 9 (9%) 14 (14%) 26 (26%)
Inflammation, Chronic 2 (2%) 1 (1%) 1 (1%) 3 (3%)
Inflammation, Chronic Active 1 (1%)
Mixed Cell Focus 25 (25%) 28 (28%) 25 (25%) 23 (23%) 18 (18%)
Necrosis 8 (8%) 6 (6%) 6 (6%) 4 (4%) 2 (2%)
Pigmentation 1 (1%) 1 (1%) 2 (2%)
Tension Lipidosis 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation, Chronic 1 (1%)
Bile Duct, Hyperplasia 79 (79%) 88 (88%) 88 (88%) 74 (74%) 79 (79%)
Centrilobular, Necrosis 1 (1%)
Hepatocyte, Degeneration 1 (1%)
Hepatocyte, Hypertrophy 1 (1%)
Hepatocyte, Vacuolization Cytoplasmic 14 (14%) 13 (13%) 19 (19%) 19 (19%) 20 (20%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (1%) 1 (1%)
Mesentery (17) (22) (27) (21) (16)
Accessory Spleen 2 (13%)
Inflammation, Chronic 1 (4%)
Artery, Hemorrhage 1 (5%)
Artery, Inflammation, Chronic 1 (6%)
Fat, Necrosis 14 (82%) 15 (68%) 23 (85%) 15 (71%) 13 (81%)
Pancreas (98) (99) (99) (99) (100)
Cyst 3 (3%) 1 (1%) 1 (1%) 1 (1%)
Fibrosis, Focal 1 (1%)
Hemorrhage 1 (1%)
Infiltration Cellular, Lymphocyte 5 (5%) 14 (14%) 13 (13%) 9 (9%) 3 (3%)
Acinus, Atrophy, Diffuse 3 (3%) 1 (1%) 1 (1%) 1 (1%)
Acinus, Atrophy, Focal 33 (34%) 26 (26%) 40 (40%) 27 (27%) 41 (41%)
Acinus, Basophilic Focus 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Acinus, Hyperplasia, Focal 20 (20%) 21 (21%) 23 (23%) 20 (20%) 18 (18%)
Acinus, Inflammation, Chronic 1 (1%) 1 (1%)
Artery, Inflammation, Chronic 1 (1%) 2 (2%) 2 (2%) 1 (1%)
Salivary Glands (99) (99) (100) (100) (100)
Mineralization 1 (1%)
Bilateral, Pigmentation 1 (1%)
Parotid Gland, Atrophy 2 (2%) 2 (2%)
Parotid Gland, Fibrosis, Focal 1 (1%)
Parotid Gland, Hyperplasia, Focal 1 (1%) 1 (1%)
Parotid Gland, Inflammation, Chronic 1 (1%)
Parotid Gland, Vacuolization Cytoplasmic,
Diffuse 1 (1%)
Sublingual Gland, Atrophy 1 (1%) 1 (1%)
Sublingual Gland, Infiltration Cellular,
Lymphocyte 1 (1%)
Sublingual Gland, Inflammation, Chronic 1 (1%)
Submandibular Gland, Atrophy 1 (1%)
Stomach, Forestomach (100) (100) (100) (100) (100)
Edema 3 (3%) 3 (3%) 5 (5%) 3 (3%) 6 (6%)
Erosion, Focal 1 (1%) 1 (1%) 1 (1%)
Inflammation, Acute 1 (1%) 1 (1%) 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%) 3 (3%)
Inflammation, Chronic Active 2 (2%) 1 (1%) 4 (4%) 4 (4%) 1 (1%)
Ulcer 1 (1%) 2 (2%) 2 (2%) 3 (3%) 7 (7%)
Epithelium, Hyperplasia 6 (6%) 5 (5%) 9 (9%) 2 (2%) 7 (7%)
Stomach, Glandular (100) (100) (100) (100) (100)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 3 (3%)
Edema 2 (2%) 1 (1%)
Erosion, Focal 9 (9%) 3 (3%) 9 (9%) 8 (8%) 11 (11%)
Hyperplasia, Focal 1 (1%) 1 (1%)
Inflammation, Acute 1 (1%) 1 (1%)
Inflammation, Chronic 1 (1%)
Inflammation, Chronic Active 1 (1%) 1 (1%) 1 (1%)
Mineralization 1 (1%) 1 (1%)
Ulcer 1 (1%)
Artery, Inflammation, Chronic 1 (1%) 1 (1%)
Epithelium, Cyst 1 (1%)
Glands, Cyst 4 (4%) 6 (6%) 1 (1%) 3 (3%) 2 (2%)
Muscularis, Mineralization 1 (1%)
Tooth (2) (1) (1) (1) (6)
Malformation 5 (83%)
Gingiva, Inflammation, Chronic Active 2 (100%) 1 (100%) 1 (17%)
Gingiva, Malformation 1 (50%)
Peridontal Tissue, Inflammation, Chronic
Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (99) (99) (99) (100) (100)
Aneurysm 1 (1%)
Inflammation, Chronic 1 (1%)
Mineralization 1 (1%) 1 (1%)
Heart (100) (100) (100) (100) (100)
Cardiomyopathy 88 (88%) 87 (87%) 88 (88%) 87 (87%) 87 (87%)
Metaplasia, Focal, Osseous 1 (1%)
Pigmentation 2 (2%)
Artery, Inflammation, Chronic 1 (1%)
Artery, Mineralization 1 (1%) 1 (1%)
Atrium, Mineralization 1 (1%)
Atrium, Thrombosis 6 (6%) 6 (6%) 6 (6%) 9 (9%) 4 (4%)
Epicardium, Inflammation, Chronic 1 (1%)
Myocardium, Necrosis 1 (1%)
Pericardium, Inflammation, Chronic 1 (1%)
Valve, Inflammation, Chronic 1 (1%) 2 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (99) (100) (100) (100) (100)
Accessory Adrenal Cortical Nodule 1 (1%) 2 (2%) 3 (3%)
Angiectasis 4 (4%) 1 (1%)
Degeneration, Focal 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (1%) 4 (4%) 3 (3%) 2 (2%) 6 (6%)
Hemorrhage 1 (1%) 1 (1%)
Hyperplasia, Focal 11 (11%) 15 (15%) 9 (9%) 11 (11%) 9 (9%)
Hypertrophy, Focal 3 (3%) 3 (3%) 6 (6%) 3 (3%)
Necrosis, Focal 2 (2%)
Pigmentation 1 (1%)
Vacuolization Cytoplasmic, Focal 14 (14%) 19 (19%) 19 (19%) 20 (20%) 19 (19%)
Bilateral, Angiectasis 5 (5%) 8 (8%) 2 (2%) 2 (2%) 2 (2%)
Bilateral, Hematopoietic Cell Proliferation 2 (2%) 3 (3%) 2 (2%) 3 (3%)
Bilateral, Hyperplasia, Focal 1 (1%)
Bilateral, Infiltration Cellular, Mixed Cell 1 (1%)
Bilateral, Necrosis 1 (1%)
Bilateral, Pigmentation 1 (1%) 1 (1%) 1 (1%)
Bilateral, Vacuolization Cytoplasmic, Diffuse 1 (1%) 2 (2%) 4 (4%) 3 (3%)
Bilateral, Vacuolization Cytoplasmic, Focal 6 (6%) 5 (5%) 4 (4%) 5 (5%) 1 (1%)
Adrenal Medulla (98) (93) (100) (100) (95)
Degeneration, Cystic 1 (1%)
Hyperplasia, Focal 14 (14%) 11 (12%) 9 (9%) 16 (16%) 13 (14%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Thrombosis 1 (1%)
Bilateral, Hyperplasia, Focal 3 (3%) 5 (5%) 2 (2%) 2 (2%) 1 (1%)
Bilateral, Infiltration Cellular, Lymphocyte 1 (1%)
Islets, Pancreatic (99) (99) (99) (99) (100)
Hyperplasia, Focal 1 (1%) 1 (1%) 9 (9%) 2 (2%) 7 (7%)
Inflammation, Chronic, Focal 1 (1%)
Metaplasia, Focal 1 (1%)
Parathyroid Gland (85) (87) (93) (81) (89)
Hyperplasia, Focal 1 (1%) 1 (1%) 1 (1%)
Pineal Gland (81) (84) (81) (79) (91)
Fibrosis 1 (1%)
Hyperplasia, Focal 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) 2 (2%)
Mineralization 42 (52%) 52 (62%) 54 (67%) 39 (49%) 57 (63%)
Pituitary Gland (98) (95) (97) (100) (98)
Inflammation, Granulomatous 1 (1%)
Pars Distalis, Angiectasis, Focal 3 (3%) 2 (2%) 4 (4%) 2 (2%) 2 (2%)
Pars Distalis, Atrophy, Focal 1 (1%)
Pars Distalis, Cyst 8 (8%) 6 (6%) 6 (6%) 16 (16%) 7 (7%)
Pars Distalis, Hemorrhage 1 (1%)
Pars Distalis, Hyperplasia, Focal 11 (11%) 15 (16%) 9 (9%) 14 (14%) 16 (16%)
Pars Distalis, Hypertrophy, Focal 2 (2%) 2 (2%) 3 (3%) 2 (2%)
Pars Distalis, Pigmentation, Focal 1 (1%)
Pars Distalis, Vacuolization Cytoplasmic 2 (2%) 1 (1%) 1 (1%)
Pars Distalis, Vacuolization Cytoplasmic,
Focal 1 (1%)
Pars Intermedia, Atypia Cellular 1 (1%)
Pars Intermedia, Cyst 3 (3%) 1 (1%) 2 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Hyperplasia, Focal 1 (1%)
Pars Nervosa, Atypia Cellular 1 (1%)
Pars Nervosa, Cyst 1 (1%)
Pars Nervosa, Degeneration, Focal 1 (1%)
Rathke's Cleft, Cyst 1 (1%) 1 (1%) 1 (1%)
Thyroid Gland (99) (100) (100) (100) (100)
Hemorrhage 1 (1%)
Inflammation, Chronic 2 (2%) 2 (2%)
Mineralization 1 (1%)
Ultimobranchial Cyst 1 (1%) 1 (1%) 4 (4%) 7 (7%) 3 (3%)
Bilateral, C-Cell, Hyperplasia, Focal 1 (1%) 1 (1%)
C-Cell, Hyperplasia 1 (1%) 3 (3%) 1 (1%) 2 (2%)
C-Cell, Hyperplasia, Diffuse 4 (4%) 1 (1%)
C-Cell, Hyperplasia, Focal 28 (28%) 22 (22%) 23 (23%) 24 (24%) 31 (31%)
Follicle, Cyst 3 (3%) 2 (2%) 5 (5%) 2 (2%) 3 (3%)
Follicular Cell, Hyperplasia, Focal 1 (1%) 2 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3) (2) (1) (2)
Necrosis 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (100) (100) (100) (100) (100)
Atrophy 1 (1%)
Granuloma Sperm 2 (2%) 3 (3%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Inflammation, Acute 1 (1%)
Inflammation, Chronic 3 (3%) 4 (4%) 4 (4%) 5 (5%) 2 (2%)
Inflammation, Chronic Active 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Inflammation, Granulomatous 1 (1%)
Artery, Inflammation, Chronic 1 (1%)
Bilateral, Inflammation, Acute 1 (1%)
Bilateral, Inflammation, Chronic 1 (1%)
Bilateral, Epithelium, Degeneration, Mucoid 58 (58%) 61 (61%) 54 (54%) 60 (60%) 54 (54%)
Epithelium, Degeneration, Mucoid 24 (24%) 15 (15%) 29 (29%) 12 (12%) 25 (25%)
Preputial Gland (100) (99) (100) (99) (100)
Cyst 1 (1%)
Hyperplasia, Focal 4 (4%) 8 (8%) 2 (2%) 4 (4%) 1 (1%)
Inflammation, Acute 1 (1%) 1 (1%)
Inflammation, Chronic 18 (18%) 19 (19%) 25 (25%) 31 (31%) 35 (35%)
Inflammation, Chronic Active 4 (4%) 3 (3%) 2 (2%) 7 (7%) 4 (4%)
Inflammation, Granulomatous 1 (1%)
Bilateral, Atrophy 1 (1%) 1 (1%) 2 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Bilateral, Inflammation, Chronic 47 (47%) 48 (48%) 44 (44%) 33 (33%) 34 (34%)
Bilateral, Inflammation, Chronic Active 11 (11%) 6 (6%) 5 (5%) 4 (4%) 11 (11%)
Prostate (100) (99) (100) (99) (100)
Atrophy 48 (48%) 57 (58%) 34 (34%) 47 (47%) 52 (52%)
Cyst 1 (1%)
Hypertrophy 1 (1%)
Infiltration Cellular, Lymphocyte 2 (2%)
Inflammation, Acute 4 (4%) 7 (7%) 15 (15%) 7 (7%) 14 (14%)
Inflammation, Chronic 6 (6%) 6 (6%) 14 (14%) 6 (6%) 7 (7%)
Inflammation, Chronic Active 36 (36%) 44 (44%) 36 (36%) 35 (35%) 39 (39%)
Artery, Inflammation, Chronic 1 (1%)
Bilateral, Inflammation, Chronic 1 (1%)
Bilateral, Inflammation, Chronic Active 1 (1%)
Epithelium, Hyperplasia, Focal 10 (10%) 7 (7%) 5 (5%) 9 (9%) 12 (12%)
Seminal Vesicle (100) (99) (100) (99) (100)
Atrophy 30 (30%) 48 (48%) 50 (50%) 38 (38%) 30 (30%)
Dilatation 2 (2%)
Inflammation, Acute 1 (1%) 1 (1%)
Inflammation, Chronic Active 1 (1%) 1 (1%)
Bilateral, Atrophy 54 (54%) 31 (31%) 36 (36%) 40 (40%) 49 (49%)
Bilateral, Dilatation 1 (1%) 2 (2%)
Testes (100) (100) (100) (100) (100)
Mineralization 1 (1%) 1 (1%) 4 (4%) 1 (1%)
Necrosis 1 (1%)
Bilateral, Inflammation, Chronic 1 (1%)
Bilateral, Mineralization 2 (2%)
Bilateral, Necrosis 1 (1%)
Bilateral, Artery, Inflammation, Chronic 1 (1%)
Bilateral, Interstitial Cell, Hyperplasia,
Diffuse 1 (1%)
Bilateral, Interstitial Cell, Hyperplasia,
Focal 3 (3%) 1 (1%) 5 (5%) 5 (5%) 3 (3%)
Bilateral, Germinal Epithelium, Atrophy 4 (4%) 3 (3%) 3 (3%) 2 (2%) 4 (4%)
Germinal Epithelium, Atrophy 6 (6%) 11 (11%) 11 (11%) 10 (10%) 9 (9%)
Germinal Epithelium, Hyperplasia, Focal 1 (1%)
Interstitial Cell, Hyperplasia, Focal 8 (8%) 8 (8%) 12 (12%) 17 (17%) 21 (21%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (100) (100) (100) (99) (100)
Depletion Cellular 3 (3%) 2 (2%) 3 (3%) 2 (2%) 6 (6%)
Hemorrhage 2 (2%) 1 (1%)
Hyperplasia 14 (14%) 18 (18%) 15 (15%) 12 (12%) 12 (12%)
Myelofibrosis 1 (1%)
Necrosis 4 (4%)
Lymph Node (15) (7) (7) (13) (8)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (7%) 1 (13%)
Mediastinal, Hemorrhage 2 (13%) 1 (14%) 1 (14%) 2 (15%) 1 (13%)
Mediastinal, Hyperplasia, Lymphoid 1 (14%)
Mediastinal, Pigmentation 1 (7%) 1 (8%)
Lymph Node, Mandibular (99) (99) (100) (100) (100)
Atrophy 1 (1%)
Degeneration, Cystic 15 (15%) 10 (10%) 11 (11%) 12 (12%) 11 (11%)
Fibrosis 1 (1%) 1 (1%)
Hemorrhage 2 (2%) 1 (1%) 7 (7%) 1 (1%)
Hyperplasia, Lymphoid 17 (17%) 15 (15%) 14 (14%) 13 (13%) 14 (14%)
Infiltration Cellular, Histiocyte 3 (3%) 4 (4%) 2 (2%)
Pigmentation 1 (1%) 1 (1%) 1 (1%) 2 (2%)
Lymph Node, Mesenteric (100) (99) (100) (100) (100)
Angiectasis 1 (1%)
Atrophy 1 (1%) 1 (1%)
Degeneration, Cystic 1 (1%) 2 (2%) 2 (2%) 1 (1%) 1 (1%)
Hematopoietic Cell Proliferation 1 (1%)
Hemorrhage 2 (2%) 2 (2%) 2 (2%) 2 (2%) 1 (1%)
Hyperplasia, Lymphoid 1 (1%) 1 (1%) 2 (2%) 3 (3%)
Infiltration Cellular, Histiocyte 65 (65%) 70 (71%) 73 (73%) 70 (70%) 80 (80%)
Inflammation, Chronic 2 (2%)
Pigmentation 1 (1%)
Artery, Inflammation, Chronic Active 1 (1%)
Spleen (100) (100) (100) (100) (100)
Accessory Spleen 1 (1%) 1 (1%) 1 (1%)
Congestion 3 (3%) 5 (5%) 1 (1%) 1 (1%)
Depletion Cellular, Focal 1 (1%) 1 (1%)
Fibrosis 1 (1%) 6 (6%) 4 (4%) 1 (1%) 1 (1%)
Hematopoietic Cell Proliferation 14 (14%) 12 (12%) 13 (13%) 15 (15%) 16 (16%)
Hemorrhage 1 (1%)
Necrosis, Focal 1 (1%)
Pigmentation 12 (12%) 11 (11%) 17 (17%) 15 (15%) 19 (19%)
Capsule, Inflammation, Chronic 3 (3%) 1 (1%)
Capsule, Pigmentation, Focal 1 (1%)
Lymphoid Follicle, Atrophy 1 (1%) 4 (4%) 3 (3%) 3 (3%) 3 (3%)
Lymphoid Follicle, Hyperplasia 1 (1%)
Thymus (97) (94) (95) (90) (95)
Atrophy 58 (60%) 46 (49%) 63 (66%) 62 (69%) 44 (46%)
Cyst 1 (1%) 2 (2%) 1 (1%) 2 (2%)
Hemorrhage 2 (2%) 3 (3%) 2 (2%) 2 (2%)
Hyperplasia, Lymphoid 1 (1%) 1 (1%) 1 (1%)
Epithelial Cell, Hyperplasia 2 (2%) 3 (3%) 3 (3%) 6 (7%) 2 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (99) (97) (100) (98) (95)
Cyst 18 (18%) 15 (15%) 10 (10%) 14 (14%) 14 (15%)
Fibrosis 2 (2%) 1 (1%) 2 (2%)
Galactocele 2 (2%) 5 (5%) 1 (1%) 5 (5%)
Inflammation, Chronic 1 (1%) 3 (3%) 1 (1%) 1 (1%)
Inflammation, Chronic Active 1 (1%)
Mineralization 2 (2%) 1 (1%) 1 (1%) 1 (1%)
Pigmentation 2 (2%) 4 (4%)
Epithelium, Hyperplasia 9 (9%) 1 (1%) 4 (4%) 3 (3%) 4 (4%)
Skin (99) (100) (100) (100) (100)
Congestion 1 (1%)
Cyst Epithelial Inclusion 4 (4%) 3 (3%) 3 (3%) 3 (3%)
Hyperkeratosis 1 (1%)
Inflammation, Acute 1 (1%)
Inflammation, Chronic Active 1 (1%)
Dermis, Fibrosis, Focal 2 (2%) 1 (1%)
Epidermis, Hyperplasia 1 (1%)
Hair Follicle, Hyperplasia, Focal 1 (1%) 1 (1%)
Lip, Hemorrhage 1 (1%)
Subcutaneous Tissue, Fibrosis 2 (2%) 1 (1%)
Subcutaneous Tissue, Hemorrhage 1 (1%)
Subcutaneous Tissue, Inflammation, Chronic 1 (1%)
Subcutaneous Tissue, Necrosis 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (100) (100) (100) (100) (100)
Cranium, Hyperostosis 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Femur, Hyperostosis 1 (1%) 2 (2%) 5 (5%) 2 (2%) 1 (1%)
Femur, Hypertrophy 1 (1%)
Maxilla, Osteomalacia 1 (1%)
Turbinate, Hyperostosis 1 (1%)
Skeletal Muscle (10) (6) (11) (4) (7)
Infiltration Cellular, Lymphocyte 1 (17%)
Inflammation, Chronic, Focal 1 (14%)
Mineralization 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (100) (100) (100) (100)
Artery, Thrombosis 1 (1%)
Cerebrum, Hemorrhage 1 (1%)
Cerebrum, Hydrocephalus 1 (1%)
Cerebrum, Infiltration Cellular, Lymphocyte 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Cerebrum, Necrosis 2 (2%) 1 (1%)
Choroid Plexus, Hyperplasia 1 (1%)
Choroid Plexus, Mineralization 1 (1%) 1 (1%)
Choroid Plexus, Cerebrum, Infiltration
Cellular, Lymphocyte 1 (1%)
Hypothalamus, Compression 5 (5%) 8 (8%) 1 (1%) 9 (9%) 8 (8%)
Hypothalamus, Necrosis, Focal 1 (1%)
Meninges, Hyperplasia 1 (1%)
Pons, Compression 1 (1%)
Thalamus, Necrosis, Focal 1 (1%)
Spinal Cord (11) (6) (9) (4) (6)
Meninges, Cyst Epithelial Inclusion 1 (9%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (100) (100) (100) (100) (100)
Congestion 5 (5%) 5 (5%) 2 (2%) 4 (4%) 3 (3%)
Edema 1 (1%)
Fibrosis, Focal 1 (1%)
Foreign Body 1 (1%)
Hemorrhage 1 (1%)
Infiltration Cellular, Lymphocyte 11 (11%) 5 (5%) 2 (2%) 3 (3%)
Infiltration Cellular, Histiocyte 8 (8%) 18 (18%) 12 (12%) 6 (6%) 5 (5%)
Inflammation, Acute 1 (1%)
Inflammation, Chronic, Focal 1 (1%)
Metaplasia, Focal, Osseous 1 (1%) 4 (4%) 1 (1%)
Alveolar Epithelium, Hyperplasia, Focal 6 (6%) 3 (3%) 7 (7%) 5 (5%) 4 (4%)
Artery, Inflammation, Chronic 1 (1%)
Bronchus, Inflammation, Acute 1 (1%) 1 (1%)
Bronchus, Inflammation, Chronic 2 (2%)
Bronchus, Inflammation, Chronic Active 1 (1%)
Interstitium, Inflammation, Acute 1 (1%)
Interstitium, Inflammation, Chronic 5 (5%) 5 (5%) 3 (3%) 2 (2%) 3 (3%)
Interstitium, Inflammation, Chronic Active 1 (1%) 2 (2%)
Serosa, Inflammation, Chronic 1 (1%)
Nose (100) (98) (100) (100) (100)
Congestion 1 (1%)
Foreign Body 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Inflammation, Acute 1 (1%) 2 (2%)
Inflammation, Chronic 5 (5%) 3 (3%) 5 (5%) 4 (4%) 3 (3%)
Inflammation, Chronic Active 22 (22%) 25 (26%) 35 (35%) 25 (25%) 31 (31%)
Metaplasia, Squamous 2 (2%)
Mineralization, Focal 1 (1%)
Glands, Cyst 1 (1%)
Nasolacrimal Duct, Inflammation, Acute 1 (1%) 1 (1%) 1 (1%)
Nasolacrimal Duct, Inflammation, Chronic 6 (6%) 8 (8%) 12 (12%) 7 (7%) 4 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (1%) 1 (1%) 3 (3%) 4 (4%)
Olfactory Epithelium, Cyst 1 (1%)
Olfactory Epithelium, Cytoplasmic Alteration 36 (36%) 32 (33%) 48 (48%) 41 (41%) 29 (29%)
Olfactory Epithelium, Mineralization 1 (1%)
Respiratory Epithelium, Cyst 1 (1%) 1 (1%)
Respiratory Epithelium, Cytoplasmic
Alteration 3 (3%) 1 (1%) 1 (1%) 1 (1%)
Respiratory Epithelium, Hyperplasia, Focal 1 (1%)
Trachea (100) (100) (100) (100) (100)
Inflammation, Chronic 10 (10%) 12 (12%) 15 (15%) 3 (3%) 12 (12%)
Inflammation, Chronic Active 1 (1%) 1 (1%)
Glands, Cyst 1 (1%) 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (7) (1)
Bilateral, Lens, Cataract 1 (14%)
Bilateral, Retina, Atrophy 3 (43%)
Iris, Inflammation, Chronic 1 (50%)
Iris, Synechia 1 (14%) 1 (100%)
Lens, Cataract 3 (100%) 1 (50%) 5 (71%) 1 (100%)
Retina, Atrophy 3 (100%) 2 (100%) 4 (57%) 1 (100%)
Harderian Gland (100) (100) (100) (100) (100)
Atrophy, Diffuse 1 (1%)
Atrophy, Focal 2 (2%) 1 (1%) 8 (8%) 2 (2%) 1 (1%)
Hyperplasia, Focal 2 (2%) 2 (2%) 4 (4%) 2 (2%)
Infiltration Cellular, Lymphocyte 26 (26%) 30 (30%) 23 (23%) 25 (25%) 44 (44%)
Inflammation, Acute 1 (1%)
Inflammation, Chronic 3 (3%) 4 (4%) 6 (6%) 2 (2%) 1 (1%)
Inflammation, Chronic Active 1 (1%)
Pigmentation 1 (1%)
Bilateral, Atrophy, Diffuse 1 (1%)
Bilateral, Atrophy, Focal 1 (1%)
Bilateral, Infiltration Cellular, Lymphocyte 17 (17%) 19 (19%) 21 (21%) 21 (21%) 16 (16%)
Bilateral, Inflammation, Chronic 5 (5%) 8 (8%) 5 (5%) 2 (2%) 5 (5%)
Bilateral, Inflammation, Chronic Active 1 (1%) 1 (1%)
Bilateral, Pigmentation 1 (1%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (100) (100) (100) (100) (100)
Cyst 1 (1%) 3 (3%) 1 (1%) 2 (2%) 1 (1%)
Fibrosis, Focal 2 (2%)
Infarct 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:24:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mineralization 16 (16%) 18 (18%) 14 (14%) 17 (17%) 16 (16%)
Nephropathy 1 (1%) 1 (1%) 2 (2%) 1 (1%) 2 (2%)
Artery, Inflammation, Chronic 1 (1%)
Bilateral, Hydronephrosis 1 (1%)
Bilateral, Mineralization 23 (23%) 10 (10%) 19 (19%) 14 (14%) 25 (25%)
Bilateral, Nephropathy 91 (91%) 84 (84%) 87 (87%) 85 (85%) 87 (87%)
Bilateral, Pigmentation 2 (2%) 1 (1%)
Bilateral, Artery, Mineralization 1 (1%)
Bilateral, Papilla, Necrosis 1 (1%) 1 (1%)
Bilateral, Pelvis, Inflammation, Acute 1 (1%)
Bilateral, Pelvis, Inflammation, Chronic 1 (1%)
Bilateral, Pelvis, Inflammation, Chronic
Active 1 (1%)
Bilateral, Renal Tubule, Crystals 1 (1%)
Bilateral, Renal Tubule, Degeneration 2 (2%) 2 (2%) 2 (2%) 1 (1%)
Bilateral, Renal Tubule, Pigmentation 29 (29%) 20 (20%) 26 (26%) 23 (23%) 35 (35%)
Papilla, Necrosis 1 (1%)
Pelvis, Inflammation, Acute 1 (1%)
Pelvis, Inflammation, Chronic 1 (1%)
Pelvis, Transitional Epithelium, Hyperplasia 2 (2%) 1 (1%)
Renal Tubule, Hyperplasia, Focal 1 (1%) 1 (1%)
Urinary Bladder (99) (96) (100) (100) (99)
Edema 2 (2%) 1 (1%)
Hemorrhage 1 (1%)
Infiltration Cellular, Lymphocyte 4 (4%) 6 (6%) 3 (3%) 6 (6%) 7 (7%)
Inflammation, Acute 3 (3%)
Inflammation, Chronic 2 (2%) 1 (1%) 1 (1%)
Ulcer 1 (1%)
Transitional Epithelium, Hyperplasia 1 (1%) 1 (1%) 2 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
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