TDMS Study 89029-06 Pathology Tables
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 MERGED GROUPS Facility: I. I. T. Research Institute Chemical CAS #: ELECTROMAG Lock Date: 09/09/97 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Merge 001 001,011 SHAM CONTROL Merge 002 002,012 SHAM CONTROL Merge 003 003,013 .02 GAUSS Merge 004 004,014 .02 GAUSS Merge 005 005,015 2 GAUSS Merge 006 006,016 2 GAUSS Merge 007 009,019 10 GAUSS Merge 008 010,020 10 GAUSS Merge 009 007,017 10 GAUSS INTER Merge 010 008,018 10 GAUSS INTER a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 100 100 100 100 100 Early Deaths Natural Death 23 18 13 18 15 Moribund Sacrifice 6 7 6 7 8 Accidently Killed 1 1 2 1 Survivors Natural Death 1 Terminal Sacrifice 69 74 79 74 77 Animals Examined Microscopically 100 100 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (97) (100) (99) (98) (100) Epithelium, Hyperplasia, Focal 1 (1%) Gallbladder (70) (84) (87) (79) (91) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Infiltration Cellular, Mixed Cell 1 (1%) Epithelium, Cyst 5 (7%) 14 (17%) 2 (2%) 3 (4%) 11 (12%) Epithelium, Cytoplasmic Alteration 1 (1%) Epithelium, Vacuolization Cytoplasmic 1 (1%) Intestine Large, Rectum (82) (90) (90) (88) (94) Lymphoid Tissue, Hyperplasia 1 (1%) Serosa, Inflammation, Chronic Active 1 (1%) Intestine Large, Cecum (78) (87) (90) (87) (92) Lymphoid Tissue, Hyperplasia 25 (32%) 33 (38%) 35 (39%) 24 (28%) 32 (35%) Lymphoid Tissue, Necrosis 1 (1%) Intestine Small, Duodenum (77) (85) (90) (87) (91) Inflammation 1 (1%) Muscularis, Hypertrophy 1 (1%) Peyer's Patch, Hyperplasia 1 (1%) 1 (1%) 2 (2%) Intestine Small, Jejunum (79) (86) (89) (91) (92) Inflammation 1 (1%) 1 (1%) Muscularis, Hypertrophy 6 (8%) 8 (9%) 5 (6%) 3 (3%) 7 (8%) Peyer's Patch, Hyperplasia 3 (4%) 6 (7%) 5 (6%) 7 (8%) Peyer's Patch, Inflammation 1 (1%) Peyer's Patch, Necrosis, Lymphoid 1 (1%) Serosa, Inflammation 1 (1%) 1 (1%) Intestine Small, Ileum (78) (85) (90) (87) (93) Inflammation 1 (1%) 1 (1%) 2 (2%) Artery, Inflammation 1 (1%) Muscularis, Hypertrophy 17 (22%) 16 (19%) 20 (22%) 17 (20%) 15 (16%) Peyer's Patch, Hyperplasia 4 (5%) 2 (2%) 4 (4%) 4 (5%) 5 (5%) Serosa, Inflammation 1 (1%) Liver (98) (97) (98) (99) (100) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Angiectasis 1 (1%) 2 (2%) 3 (3%) Basophilic Focus 2 (2%) 3 (3%) 4 (4%) 2 (2%) Basophilic Focus, Multiple 1 (1%) 1 (1%) Clear Cell Focus 4 (4%) 3 (3%) 7 (7%) 5 (5%) 4 (4%) Clear Cell Focus, Multiple 1 (1%) 1 (1%) 1 (1%) Developmental Malformation 1 (1%) 2 (2%) 1 (1%) Eosinophilic Focus 5 (5%) 3 (3%) 10 (10%) 10 (10%) 9 (9%) Eosinophilic Focus, Multiple 1 (1%) 1 (1%) 2 (2%) Fibrosis 1 (1%) Hematopoietic Cell Proliferation 1 (1%) 1 (1%) Hemorrhage 1 (1%) 1 (1%) Hepatodiaphragmatic Nodule 1 (1%) Infiltration Cellular, Focal, Mast Cell 1 (1%) Infiltration Cellular, Focal, Lymphocyte 1 (1%) 2 (2%) 1 (1%) Infiltration Cellular, Focal, Polymorphonuclear 1 (1%) Infiltration Cellular, Focal, Mixed Cell 53 (54%) 58 (60%) 48 (49%) 48 (48%) 51 (51%) Inflammation, Focal 1 (1%) Mixed Cell Focus 1 (1%) 2 (2%) 1 (1%) Necrosis 4 (4%) 2 (2%) 4 (4%) 5 (5%) Pigmentation 1 (1%) Bile Duct, Cyst 1 (1%) Hepatocyte, Vacuolization Cytoplasmic 14 (14%) 15 (15%) 14 (14%) 17 (17%) 14 (14%) Sinusoid, Centrilobular, Dilatation 1 (1%) Mesentery (36) (27) (30) (30) (53) Hemorrhage 1 (3%) 1 (4%) 1 (3%) 1 (3%) Inflammation 1 (2%) Arteriole, Inflammation 1 (2%) Artery, Mineralization 1 (3%) Fat, Inflammation 6 (17%) 4 (15%) 5 (17%) 4 (13%) 14 (26%) Fat, Necrosis 22 (61%) 16 (59%) 23 (77%) 22 (73%) 31 (58%) Pancreas (87) (94) (96) (94) (95) Angiectasis, Focal 1 (1%) Cytoplasmic Alteration 1 (1%) Infiltration Cellular, Focal, Mixed Cell 7 (8%) 12 (13%) 7 (7%) 10 (11%) 12 (13%) Infiltration Cellular, Lymphocyte 5 (6%) 1 (1%) 3 (3%) 5 (5%) Inflammation 1 (1%) 1 (1%) Lipomatosis 21 (24%) 16 (17%) 23 (24%) 29 (31%) 33 (35%) Vacuolization Cytoplasmic 12 (14%) 21 (22%) 18 (19%) 16 (17%) 15 (16%) Acinus, Cytoplasmic Alteration 1 (1%) 3 (3%) 4 (4%) 2 (2%) 5 (5%) Acinus, Degeneration, Focal 1 (1%) Acinus, Hypertrophy, Focal 1 (1%) 2 (2%) 1 (1%) Artery, Inflammation 1 (1%) 1 (1%) Duct, Cyst 1 (1%) 1 (1%) 3 (3%) 1 (1%) 2 (2%) Salivary Glands (94) (98) (97) (98) (99) Atrophy 1 (1%) 1 (1%) Fibrosis 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Infiltration Cellular, Lymphocyte 74 (79%) 83 (85%) 77 (79%) 75 (77%) 79 (80%) Infiltration Cellular, Mixed Cell 1 (1%) Pigmentation 1 (1%) Arteriole, Inflammation 1 (1%) Duct, Cyst 1 (1%) Duct, Cytoplasmic Alteration 1 (1%) Stomach, Forestomach (91) (92) (93) (94) (97) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Inflammation 3 (3%) 1 (1%) 1 (1%) Ulcer, Focal 1 (1%) 1 (1%) Epithelium, Atrophy 6 (7%) 11 (12%) 5 (5%) 10 (11%) 6 (6%) Epithelium, Cyst 1 (1%) Epithelium, Hyperplasia 4 (4%) 5 (5%) 4 (4%) 5 (5%) 5 (5%) Muscularis, Mineralization, Focal 1 (1%) Stomach, Glandular (86) (90) (93) (93) (94) Infiltration Cellular, Lymphocyte 7 (8%) 8 (9%) 3 (3%) 5 (5%) Inflammation 1 (1%) 1 (1%) 1 (1%) 1 (1%) Ulcer, Focal 1 (1%) 1 (1%) Epithelium, Atrophy 14 (16%) 24 (27%) 20 (22%) 18 (19%) 28 (30%) Epithelium, Cyst, Focal 23 (27%) 19 (21%) 17 (18%) 12 (13%) 20 (21%) Epithelium, Mineralization 1 (1%) Serosa, Hemorrhage 1 (1%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (98) (100) (94) (99) (96) Aorta, Mineralization 2 (2%) Aorta, Adventitia, Inflammation, Chronic Active 1 (1%) Heart (98) (100) (100) (99) (100) Inflammation 1 (1%) Artery, Inflammation 1 (1%) 1 (1%) 1 (1%) Artery, Mineralization 1 (1%) Atrium, Infiltration Cellular, Lymphocyte 1 (1%) Atrium, Thrombosis 1 (1%) 1 (1%) Epicardium, Inflammation, Chronic Active 1 (1%) Myocardium, Degeneration 1 (1%) 4 (4%) 1 (1%) 1 (1%) Myocardium, Inflammation 1 (1%) Myocardium, Mineralization 1 (1%) 3 (3%) 1 (1%) Myocardium, Necrosis, Focal 1 (1%) Valve, Thrombosis 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (92) (98) (99) (99) (99) Cytoplasmic Alteration, Focal 1 (1%) Degeneration, Fatty 1 (1%) Hematopoietic Cell Proliferation 2 (2%) Infiltration Cellular, Lymphocyte 1 (1%) Inflammation 1 (1%) Bilateral, Capsule, Hyperplasia 88 (96%) 88 (90%) 85 (86%) 89 (90%) 94 (95%) Bilateral, Capsule, Mineralization 1 (1%) Bilateral, Zona Fasciculata, Hypertrophy, Focal 1 (1%) Bilateral, Zona Glomerulosa, Hyperplasia, Focal 1 (1%) Bilateral, Zona Reticularis, Degeneration, Fatty 2 (2%) 4 (4%) 2 (2%) Capsule, Hyperplasia 3 (3%) 8 (8%) 12 (12%) 9 (9%) 5 (5%) Zona Fasciculata, Hyperplasia, Focal 1 (1%) 3 (3%) Zona Fasciculata, Hypertrophy, Diffuse 1 (1%) Zona Fasciculata, Hypertrophy, Focal 2 (2%) 2 (2%) 5 (5%) Zona Reticularis, Degeneration, Fatty 2 (2%) 2 (2%) 3 (3%) 1 (1%) Adrenal Medulla (90) (95) (97) (97) (98) Hyperplasia 3 (3%) 8 (8%) 2 (2%) 3 (3%) Bilateral, Amyloid Deposition 1 (1%) Islets, Pancreatic (87) (95) (94) (94) (94) Degeneration 1 (1%) Hyperplasia 40 (46%) 60 (63%) 42 (45%) 48 (51%) 47 (50%) Infiltration Cellular, Focal, Mixed Cell 2 (2%) 1 (1%) 3 (3%) 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) Inflammation, Chronic Active 1 (1%) Parathyroid Gland (63) (53) (53) (53) (58) Cyst 1 (2%) 1 (2%) Degeneration 1 (2%) Hyperplasia 11 (17%) 8 (15%) 7 (13%) 6 (11%) 8 (14%) Infiltration Cellular, Lymphocyte 2 (3%) 1 (2%) 2 (4%) 2 (4%) Infiltration Cellular, Mixed Cell 1 (2%) Inflammation, Focal 2 (4%) Vacuolization Cytoplasmic 1 (2%) 1 (2%) Pineal Gland (52) (37) (67) (61) (61) Hyperplasia 1 (2%) Infiltration Cellular, Lymphocyte 1 (2%) Inflammation 1 (2%) Pituitary Gland (83) (92) (87) (89) (93) Hemorrhage 1 (1%) Pars Distalis, Cyst 2 (2%) 3 (3%) 1 (1%) 4 (4%) Pars Distalis, Hyperplasia, Diffuse 1 (1%) Pars Distalis, Hyperplasia, Focal 37 (45%) 50 (54%) 33 (38%) 35 (39%) 35 (38%) Pars Distalis, Hypertrophy, Focal 3 (3%) 1 (1%) 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Rathke's Cleft, Cyst 1 (1%) Thyroid Gland (92) (99) (98) (98) (98) Infiltration Cellular, Lymphocyte 3 (3%) Inflammation, Focal 2 (2%) 3 (3%) 4 (4%) 2 (2%) Bilateral, Infiltration Cellular, Lymphocyte 1 (1%) Follicle, Cyst 21 (23%) 21 (21%) 25 (26%) 22 (22%) 37 (38%) Follicular Cell, Hyperplasia, Focal 3 (3%) 5 (5%) 1 (1%) 1 (1%) Follicular Cell, Hypertrophy, Diffuse 2 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) (1) (3) Inflammation, Chronic Active 1 (33%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (89) (84) (85) (84) (82) Atrophy 25 (28%) 19 (23%) 16 (19%) 21 (25%) 17 (21%) Cyst 29 (33%) 26 (31%) 15 (18%) 18 (21%) 19 (23%) Inflammation 1 (1%) 1 (1%) Arteriole, Inflammation 1 (1%) Bilateral, Atrophy 55 (62%) 56 (67%) 61 (72%) 55 (65%) 57 (70%) Bilateral, Cyst 55 (62%) 56 (67%) 66 (78%) 58 (69%) 52 (63%) Bilateral, Inflammation 2 (2%) 1 (1%) Ovary (79) (91) (95) (94) (96) Amyloid Deposition 1 (1%) Angiectasis 2 (2%) 3 (3%) 3 (3%) Atrophy 3 (4%) 1 (1%) 1 (1%) 2 (2%) 1 (1%) Cyst 20 (25%) 23 (25%) 28 (29%) 32 (34%) 21 (22%) Hemorrhage 1 (1%) 1 (1%) 1 (1%) Infiltration Cellular, Mast Cell 1 (1%) Infiltration Cellular, Mixed Cell 1 (1%) Inflammation, Chronic Active 2 (2%) Mineralization 1 (1%) 1 (1%) Pigmentation 1 (1%) Thrombosis 1 (1%) 1 (1%) Bilateral, Amyloid Deposition 1 (1%) Bilateral, Atrophy 1 (1%) 2 (2%) 2 (2%) 3 (3%) 2 (2%) Bilateral, Cyst 2 (3%) 2 (2%) 1 (1%) 3 (3%) Germinal Epithelium, Hyperplasia 1 (1%) Interstitial Cell, Hyperplasia 1 (1%) Uterus (92) (97) (98) (99) (100) Amyloid Deposition 1 (1%) 1 (1%) Angiectasis 1 (1%) 3 (3%) 2 (2%) 3 (3%) Hemorrhage 1 (1%) 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Hydrometra 24 (26%) 18 (19%) 16 (16%) 20 (20%) 22 (22%) Inflammation 2 (2%) Inflammation, Chronic 1 (1%) Thrombosis 1 (1%) Bilateral, Atrophy 1 (1%) Bilateral, Hydrometra 24 (26%) 15 (15%) 24 (24%) 21 (21%) 26 (26%) Bilateral, Endometrium, Amyloid Deposition 1 (1%) Bilateral, Endometrium, Hyperplasia, Cystic 32 (35%) 44 (45%) 41 (42%) 45 (45%) 38 (38%) Cervix, Angiectasis 1 (1%) Endometrium, Angiectasis 1 (1%) Endometrium, Hyperplasia, Cystic 22 (24%) 27 (28%) 26 (27%) 21 (21%) 24 (24%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (96) (99) (97) (99) (100) Angiectasis 1 (1%) 2 (2%) Atrophy 1 (1%) 1 (1%) Hyperplasia 23 (24%) 13 (13%) 13 (13%) 14 (14%) 19 (19%) Infiltration Cellular, Focal, Lymphocyte 1 (1%) Myelofibrosis 10 (10%) 18 (18%) 17 (18%) 10 (10%) 21 (21%) Necrosis 1 (1%) Myeloid Cell, Hyperplasia 3 (3%) Lymph Node (19) (15) (4) (14) (12) Ectasia 2 (11%) 2 (13%) 2 (50%) 1 (7%) 1 (8%) Hemorrhage 1 (5%) 2 (13%) 1 (25%) 1 (7%) 1 (8%) Hyperplasia, Reticulum Cell 1 (8%) Infiltration Cellular, Mast Cell 1 (25%) Infiltration Cellular, Histiocyte 1 (7%) 1 (8%) Lumbar, Ectasia 3 (16%) 1 (7%) 1 (25%) 2 (14%) Lumbar, Hemorrhage 4 (21%) 1 (25%) 1 (7%) Lumbar, Pigmentation 1 (5%) Mediastinal, Hemorrhage 1 (7%) Mediastinal, Infiltration Cellular, Mixed Cell 1 (7%) Renal, Ectasia 1 (7%) Lymph Node, Mandibular (84) (94) (89) (91) (92) Atrophy 3 (4%) 7 (7%) 4 (4%) 4 (4%) 3 (3%) Hemorrhage 2 (2%) 2 (2%) 1 (1%) 2 (2%) 3 (3%) Hyperplasia 8 (10%) 10 (11%) 12 (13%) 4 (4%) 4 (4%) Hyperplasia, Reticulum Cell 2 (2%) 1 (1%) 2 (2%) 2 (2%) Infiltration Cellular, Plasma Cell 2 (2%) 1 (1%) 2 (2%) 1 (1%) 1 (1%) Infiltration Cellular, Histiocyte 1 (1%) 1 (1%) Infiltration Cellular, Mixed Cell 2 (2%) 1 (1%) 2 (2%) 1 (1%) 1 (1%) Pigmentation 22 (26%) 9 (10%) 18 (20%) 10 (11%) 18 (20%) Lymph Node, Mesenteric (83) (88) (89) (92) (95) Angiectasis 1 (1%) 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Atrophy 12 (14%) 10 (11%) 24 (27%) 21 (23%) 22 (23%) Ectasia 3 (4%) 4 (4%) 2 (2%) Hemorrhage 3 (4%) 2 (2%) 4 (4%) 4 (4%) 2 (2%) Hyperplasia 2 (2%) 1 (1%) 4 (4%) 2 (2%) Hyperplasia, Reticulum Cell 3 (4%) 7 (8%) 13 (15%) 8 (9%) 15 (16%) Infiltration Cellular, Plasma Cell 5 (6%) 4 (5%) 2 (2%) 1 (1%) 6 (6%) Infiltration Cellular, Histiocyte 50 (60%) 45 (51%) 47 (53%) 43 (47%) 41 (43%) Infiltration Cellular, Mixed Cell 4 (5%) 1 (1%) 2 (2%) 5 (5%) 5 (5%) Inflammation, Focal 1 (1%) Artery, Inflammation 1 (1%) Spleen (91) (93) (95) (93) (99) Congestion 1 (1%) Fibrosis, Focal 1 (1%) Hematopoietic Cell Proliferation 74 (81%) 77 (83%) 87 (92%) 83 (89%) 92 (93%) Infarct 1 (1%) 1 (1%) Infiltration Cellular, Mast Cell 1 (1%) Infiltration Cellular, Plasma Cell 1 (1%) Pigmentation 17 (19%) 6 (6%) 8 (8%) 12 (13%) 12 (12%) Lymphoid Follicle, Atrophy 6 (7%) 4 (4%) 7 (7%) 3 (3%) 3 (3%) Lymphoid Follicle, Hyperplasia 31 (34%) 31 (33%) 32 (34%) 34 (37%) 40 (40%) Lymphoid Follicle, Necrosis 1 (1%) 1 (1%) Red Pulp, Atrophy 2 (2%) 3 (3%) Thymus (78) (92) (84) (75) (89) Angiectasis 1 (1%) 2 (2%) 3 (4%) 3 (4%) 2 (2%) Atrophy 22 (28%) 20 (22%) 24 (29%) 29 (39%) 27 (30%) Cyst, Focal 5 (6%) 2 (2%) 3 (4%) 9 (12%) 3 (3%) Hemorrhage 1 (1%) 2 (2%) Hyperplasia, Lymphoid 31 (40%) 19 (21%) 20 (24%) 24 (32%) 25 (28%) Artery, Inflammation 1 (1%) Thymocyte, Necrosis 1 (1%) 3 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (94) (98) (99) (99) (98) Hyperplasia 3 (3%) 3 (3%) 5 (5%) 2 (2%) 3 (3%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Artery, Inflammation 1 (1%) Duct, Dilatation 10 (11%) 15 (15%) 16 (16%) 17 (17%) 12 (12%) Skin (99) (100) (100) (100) (100) Hemorrhage 1 (1%) Ulcer, Focal 2 (2%) Artery, Inflammation 1 (1%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (7) (3) (3) (4) (4) Degeneration 1 (33%) Necrosis 1 (14%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (99) (100) (98) (98) (100) Infiltration Cellular, Focal, Mixed Cell 1 (1%) Artery, Inflammation 1 (1%) Cerebellum, Developmental Malformation, Focal 1 (1%) Choroid Plexus, Infiltration Cellular, Lymphocyte 1 (1%) Hypothalamus, Compression 2 (2%) 3 (3%) 3 (3%) Hypothalamus, Hemorrhage 1 (1%) Thalamus, Infiltration Cellular, Lymphocyte 1 (1%) Thalamus, Mineralization 47 (47%) 68 (68%) 55 (56%) 60 (61%) 72 (72%) Ventricle, Hydrocephalus 2 (2%) Ventricle, Infiltration Cellular, Lymphocyte 1 (1%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (95) (100) (99) (99) (100) Congestion 1 (1%) 1 (1%) Fibrosis 1 (1%) Hemorrhage 2 (2%) 1 (1%) 1 (1%) Infiltration Cellular, Lymphocyte 32 (34%) 37 (37%) 33 (33%) 34 (34%) 30 (30%) Inflammation, Focal 2 (2%) 1 (1%) 1 (1%) 1 (1%) 1 (1%) Metaplasia, Focal, Osseous 1 (1%) 1 (1%) Alveolar Epithelium, Hyperplasia, Focal 4 (4%) 1 (1%) 2 (2%) 1 (1%) Alveolus, Infiltration Cellular, Histiocyte 1 (1%) 4 (4%) 1 (1%) 2 (2%) Artery, Mineralization 2 (2%) Serosa, Inflammation 2 (2%) Trachea (94) (100) (98) (99) (98) Artery, Inflammation 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (2) (2) (1) (1) (2) Cornea, Inflammation 2 (100%) 1 (100%) Lens, Degeneration 1 (50%) Lens, Mineralization 1 (100%) Harderian Gland (98) (97) (99) (96) (97) Infiltration Cellular, Lymphocyte 13 (13%) 12 (12%) 18 (18%) 16 (17%) 20 (21%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - CONT Bilateral, Infiltration Cellular, Lymphocyte 14 (14%) 11 (11%) 18 (18%) 16 (17%) 16 (16%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (92) (96) (98) (98) (99) Hydronephrosis 1 (1%) 1 (1%) 1 (1%) Infarct, Acute 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Artery, Inflammation 1 (1%) Bilateral, Artery, Inflammation 1 (1%) Bilateral, Artery, Mineralization 1 (1%) Bilateral, Artery, Cortex, Inflammation 1 (1%) Bilateral, Cortex, Cyst, Multiple 1 (1%) Bilateral, Cortex, Infiltration Cellular, Lymphocyte 11 (12%) 8 (8%) 7 (7%) 7 (7%) 8 (8%) Bilateral, Cortex, Inflammation 1 (1%) Bilateral, Cortex, Mineralization 1 (1%) 1 (1%) Bilateral, Cortex, Renal Tubule, Accumulation, Hyaline Droplet 2 (2%) 3 (3%) Bilateral, Cortex, Renal Tubule, Degeneration 7 (8%) 11 (11%) 7 (7%) 8 (8%) 9 (9%) Bilateral, Cortex, Renal Tubule, Dilatation 1 (1%) 1 (1%) 1 (1%) 1 (1%) Bilateral, Cortex, Renal Tubule, Vacuolization Cytoplasmic 2 (2%) Bilateral, Glomerulus, Amyloid Deposition 1 (1%) Bilateral, Glomerulus, Inflammation 1 (1%) 1 (1%) Bilateral, Medulla, Infiltration Cellular, Lymphocyte 26 (28%) 29 (30%) 38 (39%) 31 (32%) 37 (37%) Bilateral, Medulla, Mineralization 1 (1%) 1 (1%) Cortex, Cyst 3 (3%) Cortex, Infiltration Cellular, Plasma Cell 1 (1%) Cortex, Infiltration Cellular, Lymphocyte 13 (14%) 9 (9%) 14 (14%) 8 (8%) 8 (8%) Cortex, Infiltration Cellular, Mixed Cell 1 (1%) Cortex, Metaplasia, Focal, Osseous 4 (4%) 3 (3%) 3 (3%) 3 (3%) 3 (3%) Cortex, Necrosis 1 (1%) Cortex, Renal Tubule, Degeneration 3 (3%) 7 (7%) 4 (4%) 4 (4%) 4 (4%) Cortex, Renal Tubule, Dilatation 2 (2%) Medulla, Cyst 1 (1%) Medulla, Infiltration Cellular, Lymphocyte 21 (23%) 24 (25%) 18 (18%) 27 (28%) 20 (20%) Medulla, Inflammation 1 (1%) 1 (1%) Medulla, Mineralization 2 (2%) 1 (1%) 1 (1%) 1 (1%) Pelvis, Calculus Micro Observation Only 3 (3%) 2 (2%) 2 (2%) 1 (1%) 2 (2%) Urinary Bladder (79) (87) (94) (89) (92) Infiltration Cellular, Plasma Cell 1 (1%) Infiltration Cellular, Lymphocyte 8 (10%) 3 (3%) 4 (4%) 6 (7%) 5 (5%) Arteriole, Inflammation 1 (1%) 1 (1%) Artery, Inflammation 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Serosa, Inflammation, Chronic Active 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 100 100 100 100 100 Early Deaths Natural Death 13 15 10 24 18 Moribund Sacrifice 11 13 6 14 8 Survivors Terminal Sacrifice 76 72 84 62 73 Natural Death 1 Animals Examined Microscopically 100 100 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (84) (83) (84) (75) (82) Congestion 1 (1%) Inflammation, Granulomatous 1 (1%) Epithelium, Cyst 4 (5%) 2 (2%) 2 (3%) 2 (2%) Epithelium, Hyperplasia, Focal 1 (1%) Intestine Large, Colon (93) (94) (92) (83) (85) Lymphoid Tissue, Hyperplasia 1 (1%) Muscularis, Hypertrophy 1 (1%) Intestine Large, Rectum (93) (90) (93) (81) (87) Lymphoid Tissue, Hyperplasia 1 (1%) Intestine Large, Cecum (90) (89) (92) (81) (85) Inflammation 1 (1%) 1 (1%) Lymphoid Tissue, Hyperplasia 41 (46%) 33 (37%) 37 (40%) 20 (25%) 46 (54%) Serosa, Fibrosis 1 (1%) Intestine Small, Duodenum (89) (88) (92) (79) (84) Infiltration Cellular, Histiocyte 1 (1%) Muscularis, Inflammation 1 (1%) Peyer's Patch, Hyperplasia 2 (2%) 1 (1%) Intestine Small, Jejunum (89) (94) (93) (80) (85) Inflammation 1 (1%) 1 (1%) Epithelium, Hyperplasia, Focal 1 (1%) Muscularis, Hypertrophy 3 (3%) 1 (1%) 2 (2%) Peyer's Patch, Hyperplasia 1 (1%) 5 (5%) 1 (1%) 1 (1%) Serosa, Inflammation 1 (1%) Intestine Small, Ileum (91) (89) (92) (81) (84) Inflammation 1 (1%) Epithelium, Degeneration 1 (1%) Muscularis, Hypertrophy 9 (10%) 8 (9%) 7 (8%) Peyer's Patch, Hyperplasia 1 (1%) 1 (1%) Serosa, Inflammation 1 (1%) Liver (100) (100) (100) (98) (99) Basophilic Focus 2 (2%) 2 (2%) Clear Cell Focus 7 (7%) 9 (9%) 9 (9%) 7 (7%) 9 (9%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Clear Cell Focus, Multiple 7 (7%) 9 (9%) 6 (6%) 4 (4%) 5 (5%) Congestion 1 (1%) Eosinophilic Focus 10 (10%) 12 (12%) 11 (11%) 14 (14%) 15 (15%) Eosinophilic Focus, Multiple 2 (2%) 1 (1%) 4 (4%) 1 (1%) 1 (1%) Hematopoietic Cell Proliferation 1 (1%) Hepatodiaphragmatic Nodule 2 (2%) Infiltration Cellular, Focal, Mixed Cell 6 (6%) 10 (10%) 14 (14%) 10 (10%) 11 (11%) Inflammation, Focal 1 (1%) Inflammation, Granulomatous 1 (1%) Metaplasia, Focal, Osseous 1 (1%) Mixed Cell Focus 4 (4%) 1 (1%) 3 (3%) 4 (4%) 3 (3%) Necrosis 7 (7%) 6 (6%) 4 (4%) 4 (4%) 3 (3%) Pigmentation 1 (1%) Thrombosis, Focal 1 (1%) Bile Duct, Cyst 2 (2%) 1 (1%) Hepatocyte, Vacuolization Cytoplasmic 13 (13%) 9 (9%) 6 (6%) 6 (6%) 5 (5%) Hepatocyte, Centrilobular, Hypertrophy 1 (1%) Sinusoid, Centrilobular, Dilatation 1 (1%) Mesentery (13) (16) (8) (10) (9) Infiltration Cellular, Histiocyte 1 (8%) Inflammation 1 (6%) 1 (10%) Artery, Inflammation 1 (8%) 1 (6%) 1 (13%) Fat, Inflammation 1 (8%) 3 (19%) 2 (25%) Fat, Necrosis 11 (85%) 11 (69%) 4 (50%) 6 (60%) 7 (78%) Pancreas (99) (99) (98) (95) (98) Cytoplasmic Alteration 1 (1%) Infiltration Cellular, Focal, Mixed Cell 1 (1%) 1 (1%) 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) 4 (4%) 2 (2%) 5 (5%) Inflammation 1 (1%) Lipomatosis 1 (1%) 11 (11%) 14 (14%) 1 (1%) 4 (4%) Necrosis 1 (1%) Vacuolization Cytoplasmic 16 (16%) 31 (31%) 28 (29%) 5 (5%) 28 (29%) Acinus, Atrophy 1 (1%) 1 (1%) 2 (2%) Acinus, Cytoplasmic Alteration 1 (1%) 3 (3%) 4 (4%) Acinus, Degeneration 1 (1%) Acinus, Hypertrophy, Focal 1 (1%) 1 (1%) Duct, Cyst 2 (2%) 1 (1%) 1 (1%) 2 (2%) Salivary Glands (99) (99) (98) (96) (99) Atrophy 1 (1%) 1 (1%) 1 (1%) 1 (1%) 1 (1%) Infiltration Cellular, Lymphocyte 66 (67%) 65 (66%) 72 (73%) 61 (64%) 69 (70%) Vacuolization Cytoplasmic 1 (1%) Stomach, Forestomach (99) (98) (97) (96) (99) Diverticulum 1 (1%) Inflammation, Focal 1 (1%) 1 (1%) Epithelium, Atrophy 9 (9%) 10 (10%) 8 (8%) 7 (7%) 8 (8%) Epithelium, Hyperplasia 3 (3%) 1 (1%) Epithelium, Hyperplasia, Focal 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 13 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Epithelium, Vacuolization Cytoplasmic 1 (1%) Stomach, Glandular (94) (93) (97) (87) (93) Erosion, Focal 1 (1%) Inflammation 3 (3%) 1 (1%) 1 (1%) Epithelium, Atrophy 8 (9%) 9 (10%) 8 (8%) 8 (9%) 10 (11%) Epithelium, Cyst, Focal 6 (6%) 10 (11%) 10 (10%) 3 (3%) 11 (12%) Epithelium, Hyperplasia, Focal 1 (1%) Epithelium, Mineralization 1 (1%) 1 (1%) Serosa, Inflammation 1 (1%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (97) (94) (100) (96) (98) Aorta, Mineralization 1 (1%) 1 (1%) Heart (100) (100) (100) (99) (100) Inflammation, Focal 2 (2%) 1 (1%) 5 (5%) 2 (2%) 2 (2%) Arteriole, Inflammation 1 (1%) Arteriole, Mineralization 1 (1%) Artery, Inflammation 1 (1%) 1 (1%) Artery, Mineralization 1 (1%) 1 (1%) Atrium, Infiltration Cellular 1 (1%) Atrium, Thrombosis 1 (1%) Capillary, Myocardium, Infiltration Cellular, Focal 1 (1%) Epicardium, Mineralization 1 (1%) 1 (1%) Myocardium, Degeneration 2 (2%) 2 (2%) Myocardium, Mineralization 1 (1%) Myocardium, Necrosis, Focal 1 (1%) Valve, Thrombosis 2 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (99) (96) (99) (94) (97) Bilateral, Mineralization 1 (1%) Bilateral, Capsule, Hyperplasia 55 (56%) 52 (54%) 53 (54%) 50 (53%) 52 (54%) Bilateral, Capsule, Mineralization 1 (1%) 1 (1%) Bilateral, Zona Fasciculata, Hyperplasia, Focal 1 (1%) 1 (1%) Bilateral, Zona Fasciculata, Hypertrophy 1 (1%) 2 (2%) 2 (2%) Bilateral, Zona Fasciculata, Hypertrophy, Focal 2 (2%) 3 (3%) 6 (6%) 2 (2%) 3 (3%) Capsule, Hyperplasia 31 (31%) 31 (32%) 38 (38%) 31 (33%) 33 (34%) Zona Fasciculata, Degeneration, Focal 1 (1%) Zona Fasciculata, Hyperplasia, Focal 3 (3%) 6 (6%) 7 (7%) 2 (2%) 5 (5%) Zona Fasciculata, Hypertrophy 8 (8%) 14 (15%) 11 (11%) 7 (7%) 5 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 14 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Zona Fasciculata, Hypertrophy, Focal 13 (13%) 17 (18%) 15 (15%) 10 (11%) 16 (16%) Zona Fasciculata, Infiltration Cellular, Polymorphonuclear 1 (1%) Zona Fasciculata, Vacuolization Cytoplasmic 2 (2%) Zona Fasciculata, Vacuolization Cytoplasmic, Focal 1 (1%) Zona Glomerulosa, Hyperplasia, Focal 3 (3%) 7 (7%) 4 (4%) 2 (2%) 7 (7%) Zona Reticularis, Degeneration, Fatty 1 (1%) 1 (1%) Adrenal Medulla (98) (93) (99) (91) (96) Angiectasis 1 (1%) Hyperplasia 2 (2%) 3 (3%) 3 (3%) 5 (5%) Islets, Pancreatic (99) (99) (98) (97) (98) Hyperplasia 97 (98%) 88 (89%) 84 (86%) 84 (87%) 89 (91%) Hypertrophy, Focal 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) Infiltration Cellular, Histiocyte 1 (1%) 1 (1%) Parathyroid Gland (66) (55) (72) (65) (67) Cyst 1 (2%) 1 (1%) 1 (2%) 2 (3%) Hyperplasia 1 (2%) 2 (4%) 2 (3%) 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) Infiltration Cellular, Mixed Cell 1 (2%) Pituitary Gland (83) (84) (82) (84) (86) Pars Distalis, Cyst 9 (11%) 7 (8%) 6 (7%) 4 (5%) 14 (16%) Pars Distalis, Hyperplasia, Focal 1 (1%) 2 (2%) 1 (1%) 3 (4%) 1 (1%) Pars Nervosa, Cyst 1 (1%) Thyroid Gland (99) (98) (98) (97) (98) Bilateral, Follicle, Cyst 1 (1%) Follicle, Cyst 5 (5%) 13 (13%) 7 (7%) 7 (7%) 9 (9%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (2) (4) (1) (1) Inflammation, Acute 1 (25%) Abdominal, Fat, Necrosis 1 (50%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Coagulating Gland (2) (2) (1) Cyst 1 (50%) 1 (50%) 1 (100%) Bilateral, Cyst 1 (50%) Epididymis (98) (99) (99) (96) (98) Cyst 1 (1%) Granuloma Sperm 2 (2%) 2 (2%) 1 (1%) 2 (2%) Hyperplasia 1 (1%) Infiltration Cellular, Lymphocyte 13 (13%) 9 (9%) 16 (16%) 14 (15%) 15 (15%) a Number of animals examined microscopically at site and number of animals with lesion Page 15 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Inflammation 2 (2%) Inflammation, Granulomatous 1 (1%) Spermatocele 2 (2%) 3 (3%) 7 (7%) 6 (6%) Bilateral, Atrophy 1 (1%) Bilateral, Granuloma Sperm 1 (1%) 1 (1%) Bilateral, Infiltration Cellular, Lymphocyte 11 (11%) 2 (2%) 5 (5%) 4 (4%) 9 (9%) Preputial Gland (98) (98) (100) (95) (99) Atrophy 8 (8%) 22 (22%) 15 (15%) 10 (11%) 18 (18%) Cyst 29 (30%) 13 (13%) 7 (7%) 23 (24%) 17 (17%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Inflammation 15 (15%) 18 (18%) 33 (33%) 27 (28%) 34 (34%) Bilateral, Atrophy 17 (17%) 34 (35%) 34 (34%) 27 (28%) 38 (38%) Bilateral, Cyst 55 (56%) 75 (77%) 86 (86%) 53 (56%) 72 (73%) Bilateral, Inflammation 31 (32%) 19 (19%) 23 (23%) 26 (27%) 27 (27%) Bilateral, Mineralization 1 (1%) Prostate (98) (92) (94) (94) (92) Atrophy 1 (1%) Infiltration Cellular, Lymphocyte 2 (2%) 4 (4%) 4 (4%) 2 (2%) 6 (7%) Inflammation 1 (1%) 1 (1%) Epithelium, Hyperplasia 49 (50%) 52 (57%) 56 (60%) 47 (50%) 45 (49%) Seminal Vesicle (99) (97) (98) (98) (98) Atrophy 2 (2%) 1 (1%) Cyst 28 (28%) 22 (23%) 23 (23%) 19 (19%) 16 (16%) Infiltration Cellular, Lymphocyte 1 (1%) Inflammation 2 (2%) 2 (2%) Bilateral, Atrophy 1 (1%) 1 (1%) Bilateral, Cyst 52 (53%) 41 (42%) 36 (37%) 49 (50%) 42 (43%) Bilateral, Inflammation 1 (1%) Testes (99) (98) (100) (96) (98) Atrophy 3 (3%) 3 (3%) 1 (1%) 2 (2%) 1 (1%) Hemorrhage, Focal 1 (1%) Mineralization 1 (1%) 1 (1%) 1 (1%) Necrosis 1 (1%) Bilateral, Atrophy 2 (2%) 6 (6%) 1 (1%) Interstitial Cell, Hyperplasia, Focal 1 (1%) Tunic, Inflammation 1 (1%) Tunic, Mineralization 1 (1%) 1 (1%) 1 (1%) Tunic, Mineralization, Focal 1 (1%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (99) (99) (99) (99) (100) Atrophy 1 (1%) 1 (1%) 3 (3%) Fibrosis 1 (1%) Hyperplasia 33 (33%) 30 (30%) 28 (28%) 30 (30%) 25 (25%) Infiltration Cellular, Focal, Lymphocyte 3 (3%) 1 (1%) 2 (2%) 2 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 16 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Myelofibrosis 1 (1%) 2 (2%) 2 (2%) Necrosis 1 (1%) Thrombosis 1 (1%) Erythroid Cell, Atrophy 1 (1%) Myeloid Cell, Hyperplasia 2 (2%) 3 (3%) 5 (5%) Lymph Node (6) (6) (5) (3) (7) Inflammation, Focal 1 (17%) Inguinal, Hemorrhage 1 (20%) Inguinal, Hyperplasia 1 (20%) Inguinal, Necrosis 1 (20%) Lumbar, Hemorrhage 1 (17%) Lumbar, Hyperplasia 1 (14%) Lumbar, Infiltration Cellular, Plasma Cell 1 (17%) Lymph Node, Mandibular (92) (92) (92) (89) (90) Atrophy 4 (4%) 2 (2%) 3 (3%) 4 (4%) 1 (1%) Hemorrhage 1 (1%) 1 (1%) Hyperplasia 1 (1%) 4 (4%) 1 (1%) 1 (1%) 3 (3%) Infiltration Cellular, Mast Cell 1 (1%) 1 (1%) 7 (8%) 2 (2%) Infiltration Cellular, Plasma Cell 2 (2%) 3 (3%) 2 (2%) 1 (1%) Infiltration Cellular, Polymorphonuclear 1 (1%) Infiltration Cellular, Histiocyte 1 (1%) 3 (3%) Infiltration Cellular, Mixed Cell 4 (4%) 2 (2%) 3 (3%) 1 (1%) Necrosis 1 (1%) Pigmentation 2 (2%) 4 (4%) 3 (3%) 2 (2%) 4 (4%) Lymph Node, Mesenteric (87) (90) (96) (85) (92) Atrophy 6 (7%) 12 (13%) 14 (15%) 7 (8%) 12 (13%) Hematopoietic Cell Proliferation 1 (1%) Hemorrhage 3 (3%) 2 (2%) 3 (3%) 3 (4%) 5 (5%) Hyperplasia 7 (8%) 5 (5%) 1 (1%) 3 (3%) Infiltration Cellular, Plasma Cell 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Infiltration Cellular, Histiocyte 59 (68%) 67 (74%) 79 (82%) 56 (66%) 72 (78%) Infiltration Cellular, Mixed Cell 3 (3%) 5 (6%) 2 (2%) 3 (4%) 6 (7%) Necrosis 1 (1%) Pigmentation 1 (1%) Artery, Inflammation 1 (1%) Spleen (99) (98) (98) (93) (98) Hematopoietic Cell Proliferation 37 (37%) 43 (44%) 52 (53%) 36 (39%) 48 (49%) Pigmentation 1 (1%) 1 (1%) Capsule, Degeneration, Focal 1 (1%) Lymphoid Follicle, Atrophy 11 (11%) 12 (12%) 8 (8%) 14 (15%) 8 (8%) Lymphoid Follicle, Hyperplasia 21 (21%) 27 (28%) 17 (17%) 13 (14%) 19 (19%) Red Pulp, Atrophy 4 (4%) 3 (3%) 4 (4%) 4 (4%) Red Pulp, Pigmentation 1 (1%) Thymus (69) (68) (63) (68) (60) Atrophy 62 (90%) 50 (74%) 47 (75%) 64 (94%) 44 (73%) Cyst, Focal 4 (6%) 10 (15%) 9 (14%) 4 (6%) 5 (8%) a Number of animals examined microscopically at site and number of animals with lesion Page 17 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hemorrhage 1 (1%) 1 (2%) Hyperplasia, Lymphoid 3 (4%) 5 (7%) 9 (14%) 5 (8%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (2) (1) (3) (4) (1) Hyperplasia 1 (33%) Duct, Dilatation 1 (25%) Skin (99) (99) (100) (100) (100) Cyst 1 (1%) 1 (1%) Inflammation 1 (1%) 1 (1%) 1 (1%) 1 (1%) Ulcer, Focal 1 (1%) 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (97) (100) (99) (99) (99) Cartilage, Epiphysis, Femur, Cyst 1 (1%) Cartilage, Epiphysis, Femur, Cyst, Multiple 1 (1%) Femur, Fibrous Osteodystrophy 1 (1%) Vertebra, Inflammation 1 (1%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (100) (99) (100) (99) (100) Hydrocephalus 1 (1%) Cerebellum, Developmental Malformation 1 (1%) Cerebellum, Hemorrhage 1 (1%) Cerebrum, Vacuolization Cytoplasmic, Focal 1 (1%) Thalamus, Mineralization 70 (70%) 68 (69%) 60 (60%) 78 (79%) 63 (63%) Thalamus, Vacuolization Cytoplasmic, Focal 1 (1%) Peripheral Nerve (7) (8) (2) (6) (3) Sciatic, Degeneration 1 (13%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (100) (99) (100) (99) (99) Congestion 1 (1%) 2 (2%) Infiltration Cellular, Lymphocyte 21 (21%) 16 (16%) 22 (22%) 24 (24%) 16 (16%) Inflammation, Focal 3 (3%) 1 (1%) 3 (3%) 2 (2%) Mineralization, Focal 1 (1%) Alveolar Epithelium, Hyperplasia, Focal 2 (2%) 2 (2%) 3 (3%) 2 (2%) Alveolus, Infiltration Cellular, Histiocyte 3 (3%) 5 (5%) 4 (4%) 3 (3%) 9 (9%) Arteriole, Thrombosis 1 (1%) 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 18 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Serosa, Inflammation 1 (1%) Nose (99) (99) (100) (97) (100) Inflammation 1 (1%) 2 (2%) 3 (3%) 2 (2%) 7 (7%) Sinus, Inflammation 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (2) (2) (1) Atrophy 1 (50%) Cornea, Inflammation 1 (50%) Harderian Gland (99) (99) (100) (96) (99) Atrophy, Focal 1 (1%) 1 (1%) Infiltration Cellular, Lymphocyte 8 (8%) 11 (11%) 10 (10%) 4 (4%) 9 (9%) Inflammation 1 (1%) Inflammation, Focal 1 (1%) 1 (1%) 1 (1%) Necrosis, Focal 1 (1%) Bilateral, Infiltration Cellular, Lymphocyte 3 (3%) 2 (2%) 6 (6%) 5 (5%) 5 (5%) Epithelium, Hypertrophy, Focal 1 (1%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (99) (98) (99) (96) (97) Hydronephrosis 1 (1%) 1 (1%) Infarct, Focal 1 (1%) 3 (3%) 1 (1%) 1 (1%) Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%) Arteriole, Inflammation 1 (1%) Artery, Inflammation 1 (1%) Bilateral, Hydronephrosis 1 (1%) 2 (2%) Bilateral, Infarct, Focal 1 (1%) Bilateral, Artery, Inflammation 1 (1%) 1 (1%) Bilateral, Capsule, Mineralization 1 (1%) Bilateral, Cortex, Congestion 2 (2%) 2 (2%) Bilateral, Cortex, Cyst 4 (4%) 7 (7%) 6 (6%) 6 (6%) 2 (2%) Bilateral, Cortex, Infiltration Cellular, Lymphocyte 10 (10%) 8 (8%) 8 (8%) 10 (10%) 19 (20%) Bilateral, Cortex, Inflammation 1 (1%) Bilateral, Cortex, Mineralization 79 (80%) 78 (80%) 77 (78%) 66 (69%) 74 (76%) Bilateral, Cortex, Renal Tubule, Degeneration 72 (73%) 75 (77%) 76 (77%) 57 (59%) 71 (73%) Bilateral, Cortex, Renal Tubule, Dilatation 2 (2%) 1 (1%) 1 (1%) 5 (5%) 2 (2%) Bilateral, Cortex, Renal Tubule, Pigmentation 1 (1%) 2 (2%) 2 (2%) 1 (1%) Bilateral, Medulla, Infiltration Cellular, Lymphocyte 34 (34%) 26 (27%) 37 (37%) 26 (27%) 38 (39%) Bilateral, Medulla, Inflammation 1 (1%) 1 (1%) Bilateral, Medulla, Mineralization 1 (1%) 1 (1%) Bilateral, Papilla, Necrosis 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 19 NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98 Route: MAGNETIC FIELDS Time: 12:39:32 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS CONTROL GAUSS GAUSS INTER ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Cortex, Cyst 19 (19%) 23 (23%) 21 (21%) 11 (11%) 20 (21%) Cortex, Degeneration, Focal 1 (1%) 1 (1%) Cortex, Infiltration Cellular, Focal, Mixed Cell 1 (1%) Cortex, Infiltration Cellular, Lymphocyte 9 (9%) 10 (10%) 13 (13%) 6 (6%) 18 (19%) Cortex, Inflammation 1 (1%) 2 (2%) Cortex, Metaplasia, Focal, Osseous 4 (4%) 4 (4%) 8 (8%) 2 (2%) 4 (4%) Cortex, Mineralization 1 (1%) 3 (3%) Cortex, Renal Tubule, Degeneration 4 (4%) 2 (2%) 2 (2%) 1 (1%) 1 (1%) Cortex, Renal Tubule, Dilatation 1 (1%) 2 (2%) Glomerulus, Inflammation, Focal 1 (1%) Medulla, Infiltration Cellular, Lymphocyte 21 (21%) 14 (14%) 19 (19%) 15 (16%) 9 (9%) Medulla, Inflammation 1 (1%) 1 (1%) Medulla, Mineralization 1 (1%) Urethra (1) Cyst 1 (100%) Urinary Bladder (98) (95) (95) (93) (94) Hemorrhage 1 (1%) Infiltration Cellular, Lymphocyte 4 (4%) 1 (1%) 1 (1%) 4 (4%) Inflammation 1 (1%) 1 (1%) Artery, Inflammation 1 (1%) Transitional Epithelium, Hyperplasia 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 20 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------