TDMS Study 89029-06 Pathology Tables
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
MERGED GROUPS
Facility: I. I. T. Research Institute
Chemical CAS #: ELECTROMAG
Lock Date: 09/09/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Merge 001 001,011 SHAM CONTROL
Merge 002 002,012 SHAM CONTROL
Merge 003 003,013 .02 GAUSS
Merge 004 004,014 .02 GAUSS
Merge 005 005,015 2 GAUSS
Merge 006 006,016 2 GAUSS
Merge 007 009,019 10 GAUSS
Merge 008 010,020 10 GAUSS
Merge 009 007,017 10 GAUSS INTER
Merge 010 008,018 10 GAUSS INTER
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 100 100 100 100 100
Early Deaths
Natural Death 23 18 13 18 15
Moribund Sacrifice 6 7 6 7 8
Accidently Killed 1 1 2 1
Survivors
Natural Death 1
Terminal Sacrifice 69 74 79 74 77
Animals Examined Microscopically 100 100 100 100 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (97) (100) (99) (98) (100)
Epithelium, Hyperplasia, Focal 1 (1%)
Gallbladder (70) (84) (87) (79) (91)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Infiltration Cellular, Mixed Cell 1 (1%)
Epithelium, Cyst 5 (7%) 14 (17%) 2 (2%) 3 (4%) 11 (12%)
Epithelium, Cytoplasmic Alteration 1 (1%)
Epithelium, Vacuolization Cytoplasmic 1 (1%)
Intestine Large, Rectum (82) (90) (90) (88) (94)
Lymphoid Tissue, Hyperplasia 1 (1%)
Serosa, Inflammation, Chronic Active 1 (1%)
Intestine Large, Cecum (78) (87) (90) (87) (92)
Lymphoid Tissue, Hyperplasia 25 (32%) 33 (38%) 35 (39%) 24 (28%) 32 (35%)
Lymphoid Tissue, Necrosis 1 (1%)
Intestine Small, Duodenum (77) (85) (90) (87) (91)
Inflammation 1 (1%)
Muscularis, Hypertrophy 1 (1%)
Peyer's Patch, Hyperplasia 1 (1%) 1 (1%) 2 (2%)
Intestine Small, Jejunum (79) (86) (89) (91) (92)
Inflammation 1 (1%) 1 (1%)
Muscularis, Hypertrophy 6 (8%) 8 (9%) 5 (6%) 3 (3%) 7 (8%)
Peyer's Patch, Hyperplasia 3 (4%) 6 (7%) 5 (6%) 7 (8%)
Peyer's Patch, Inflammation 1 (1%)
Peyer's Patch, Necrosis, Lymphoid 1 (1%)
Serosa, Inflammation 1 (1%) 1 (1%)
Intestine Small, Ileum (78) (85) (90) (87) (93)
Inflammation 1 (1%) 1 (1%) 2 (2%)
Artery, Inflammation 1 (1%)
Muscularis, Hypertrophy 17 (22%) 16 (19%) 20 (22%) 17 (20%) 15 (16%)
Peyer's Patch, Hyperplasia 4 (5%) 2 (2%) 4 (4%) 4 (5%) 5 (5%)
Serosa, Inflammation 1 (1%)
Liver (98) (97) (98) (99) (100)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Angiectasis 1 (1%) 2 (2%) 3 (3%)
Basophilic Focus 2 (2%) 3 (3%) 4 (4%) 2 (2%)
Basophilic Focus, Multiple 1 (1%) 1 (1%)
Clear Cell Focus 4 (4%) 3 (3%) 7 (7%) 5 (5%) 4 (4%)
Clear Cell Focus, Multiple 1 (1%) 1 (1%) 1 (1%)
Developmental Malformation 1 (1%) 2 (2%) 1 (1%)
Eosinophilic Focus 5 (5%) 3 (3%) 10 (10%) 10 (10%) 9 (9%)
Eosinophilic Focus, Multiple 1 (1%) 1 (1%) 2 (2%)
Fibrosis 1 (1%)
Hematopoietic Cell Proliferation 1 (1%) 1 (1%)
Hemorrhage 1 (1%) 1 (1%)
Hepatodiaphragmatic Nodule 1 (1%)
Infiltration Cellular, Focal, Mast Cell 1 (1%)
Infiltration Cellular, Focal, Lymphocyte 1 (1%) 2 (2%) 1 (1%)
Infiltration Cellular, Focal,
Polymorphonuclear 1 (1%)
Infiltration Cellular, Focal, Mixed Cell 53 (54%) 58 (60%) 48 (49%) 48 (48%) 51 (51%)
Inflammation, Focal 1 (1%)
Mixed Cell Focus 1 (1%) 2 (2%) 1 (1%)
Necrosis 4 (4%) 2 (2%) 4 (4%) 5 (5%)
Pigmentation 1 (1%)
Bile Duct, Cyst 1 (1%)
Hepatocyte, Vacuolization Cytoplasmic 14 (14%) 15 (15%) 14 (14%) 17 (17%) 14 (14%)
Sinusoid, Centrilobular, Dilatation 1 (1%)
Mesentery (36) (27) (30) (30) (53)
Hemorrhage 1 (3%) 1 (4%) 1 (3%) 1 (3%)
Inflammation 1 (2%)
Arteriole, Inflammation 1 (2%)
Artery, Mineralization 1 (3%)
Fat, Inflammation 6 (17%) 4 (15%) 5 (17%) 4 (13%) 14 (26%)
Fat, Necrosis 22 (61%) 16 (59%) 23 (77%) 22 (73%) 31 (58%)
Pancreas (87) (94) (96) (94) (95)
Angiectasis, Focal 1 (1%)
Cytoplasmic Alteration 1 (1%)
Infiltration Cellular, Focal, Mixed Cell 7 (8%) 12 (13%) 7 (7%) 10 (11%) 12 (13%)
Infiltration Cellular, Lymphocyte 5 (6%) 1 (1%) 3 (3%) 5 (5%)
Inflammation 1 (1%) 1 (1%)
Lipomatosis 21 (24%) 16 (17%) 23 (24%) 29 (31%) 33 (35%)
Vacuolization Cytoplasmic 12 (14%) 21 (22%) 18 (19%) 16 (17%) 15 (16%)
Acinus, Cytoplasmic Alteration 1 (1%) 3 (3%) 4 (4%) 2 (2%) 5 (5%)
Acinus, Degeneration, Focal 1 (1%)
Acinus, Hypertrophy, Focal 1 (1%) 2 (2%) 1 (1%)
Artery, Inflammation 1 (1%) 1 (1%)
Duct, Cyst 1 (1%) 1 (1%) 3 (3%) 1 (1%) 2 (2%)
Salivary Glands (94) (98) (97) (98) (99)
Atrophy 1 (1%) 1 (1%)
Fibrosis 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infiltration Cellular, Lymphocyte 74 (79%) 83 (85%) 77 (79%) 75 (77%) 79 (80%)
Infiltration Cellular, Mixed Cell 1 (1%)
Pigmentation 1 (1%)
Arteriole, Inflammation 1 (1%)
Duct, Cyst 1 (1%)
Duct, Cytoplasmic Alteration 1 (1%)
Stomach, Forestomach (91) (92) (93) (94) (97)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Inflammation 3 (3%) 1 (1%) 1 (1%)
Ulcer, Focal 1 (1%) 1 (1%)
Epithelium, Atrophy 6 (7%) 11 (12%) 5 (5%) 10 (11%) 6 (6%)
Epithelium, Cyst 1 (1%)
Epithelium, Hyperplasia 4 (4%) 5 (5%) 4 (4%) 5 (5%) 5 (5%)
Muscularis, Mineralization, Focal 1 (1%)
Stomach, Glandular (86) (90) (93) (93) (94)
Infiltration Cellular, Lymphocyte 7 (8%) 8 (9%) 3 (3%) 5 (5%)
Inflammation 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Ulcer, Focal 1 (1%) 1 (1%)
Epithelium, Atrophy 14 (16%) 24 (27%) 20 (22%) 18 (19%) 28 (30%)
Epithelium, Cyst, Focal 23 (27%) 19 (21%) 17 (18%) 12 (13%) 20 (21%)
Epithelium, Mineralization 1 (1%)
Serosa, Hemorrhage 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (98) (100) (94) (99) (96)
Aorta, Mineralization 2 (2%)
Aorta, Adventitia, Inflammation, Chronic
Active 1 (1%)
Heart (98) (100) (100) (99) (100)
Inflammation 1 (1%)
Artery, Inflammation 1 (1%) 1 (1%) 1 (1%)
Artery, Mineralization 1 (1%)
Atrium, Infiltration Cellular, Lymphocyte 1 (1%)
Atrium, Thrombosis 1 (1%) 1 (1%)
Epicardium, Inflammation, Chronic Active 1 (1%)
Myocardium, Degeneration 1 (1%) 4 (4%) 1 (1%) 1 (1%)
Myocardium, Inflammation 1 (1%)
Myocardium, Mineralization 1 (1%) 3 (3%) 1 (1%)
Myocardium, Necrosis, Focal 1 (1%)
Valve, Thrombosis 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (92) (98) (99) (99) (99)
Cytoplasmic Alteration, Focal 1 (1%)
Degeneration, Fatty 1 (1%)
Hematopoietic Cell Proliferation 2 (2%)
Infiltration Cellular, Lymphocyte 1 (1%)
Inflammation 1 (1%)
Bilateral, Capsule, Hyperplasia 88 (96%) 88 (90%) 85 (86%) 89 (90%) 94 (95%)
Bilateral, Capsule, Mineralization 1 (1%)
Bilateral, Zona Fasciculata, Hypertrophy,
Focal 1 (1%)
Bilateral, Zona Glomerulosa, Hyperplasia,
Focal 1 (1%)
Bilateral, Zona Reticularis, Degeneration,
Fatty 2 (2%) 4 (4%) 2 (2%)
Capsule, Hyperplasia 3 (3%) 8 (8%) 12 (12%) 9 (9%) 5 (5%)
Zona Fasciculata, Hyperplasia, Focal 1 (1%) 3 (3%)
Zona Fasciculata, Hypertrophy, Diffuse 1 (1%)
Zona Fasciculata, Hypertrophy, Focal 2 (2%) 2 (2%) 5 (5%)
Zona Reticularis, Degeneration, Fatty 2 (2%) 2 (2%) 3 (3%) 1 (1%)
Adrenal Medulla (90) (95) (97) (97) (98)
Hyperplasia 3 (3%) 8 (8%) 2 (2%) 3 (3%)
Bilateral, Amyloid Deposition 1 (1%)
Islets, Pancreatic (87) (95) (94) (94) (94)
Degeneration 1 (1%)
Hyperplasia 40 (46%) 60 (63%) 42 (45%) 48 (51%) 47 (50%)
Infiltration Cellular, Focal, Mixed Cell 2 (2%) 1 (1%) 3 (3%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%)
Inflammation, Chronic Active 1 (1%)
Parathyroid Gland (63) (53) (53) (53) (58)
Cyst 1 (2%) 1 (2%)
Degeneration 1 (2%)
Hyperplasia 11 (17%) 8 (15%) 7 (13%) 6 (11%) 8 (14%)
Infiltration Cellular, Lymphocyte 2 (3%) 1 (2%) 2 (4%) 2 (4%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Focal 2 (4%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Pineal Gland (52) (37) (67) (61) (61)
Hyperplasia 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation 1 (2%)
Pituitary Gland (83) (92) (87) (89) (93)
Hemorrhage 1 (1%)
Pars Distalis, Cyst 2 (2%) 3 (3%) 1 (1%) 4 (4%)
Pars Distalis, Hyperplasia, Diffuse 1 (1%)
Pars Distalis, Hyperplasia, Focal 37 (45%) 50 (54%) 33 (38%) 35 (39%) 35 (38%)
Pars Distalis, Hypertrophy, Focal 3 (3%) 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Rathke's Cleft, Cyst 1 (1%)
Thyroid Gland (92) (99) (98) (98) (98)
Infiltration Cellular, Lymphocyte 3 (3%)
Inflammation, Focal 2 (2%) 3 (3%) 4 (4%) 2 (2%)
Bilateral, Infiltration Cellular, Lymphocyte 1 (1%)
Follicle, Cyst 21 (23%) 21 (21%) 25 (26%) 22 (22%) 37 (38%)
Follicular Cell, Hyperplasia, Focal 3 (3%) 5 (5%) 1 (1%) 1 (1%)
Follicular Cell, Hypertrophy, Diffuse 2 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (3)
Inflammation, Chronic Active 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (89) (84) (85) (84) (82)
Atrophy 25 (28%) 19 (23%) 16 (19%) 21 (25%) 17 (21%)
Cyst 29 (33%) 26 (31%) 15 (18%) 18 (21%) 19 (23%)
Inflammation 1 (1%) 1 (1%)
Arteriole, Inflammation 1 (1%)
Bilateral, Atrophy 55 (62%) 56 (67%) 61 (72%) 55 (65%) 57 (70%)
Bilateral, Cyst 55 (62%) 56 (67%) 66 (78%) 58 (69%) 52 (63%)
Bilateral, Inflammation 2 (2%) 1 (1%)
Ovary (79) (91) (95) (94) (96)
Amyloid Deposition 1 (1%)
Angiectasis 2 (2%) 3 (3%) 3 (3%)
Atrophy 3 (4%) 1 (1%) 1 (1%) 2 (2%) 1 (1%)
Cyst 20 (25%) 23 (25%) 28 (29%) 32 (34%) 21 (22%)
Hemorrhage 1 (1%) 1 (1%) 1 (1%)
Infiltration Cellular, Mast Cell 1 (1%)
Infiltration Cellular, Mixed Cell 1 (1%)
Inflammation, Chronic Active 2 (2%)
Mineralization 1 (1%) 1 (1%)
Pigmentation 1 (1%)
Thrombosis 1 (1%) 1 (1%)
Bilateral, Amyloid Deposition 1 (1%)
Bilateral, Atrophy 1 (1%) 2 (2%) 2 (2%) 3 (3%) 2 (2%)
Bilateral, Cyst 2 (3%) 2 (2%) 1 (1%) 3 (3%)
Germinal Epithelium, Hyperplasia 1 (1%)
Interstitial Cell, Hyperplasia 1 (1%)
Uterus (92) (97) (98) (99) (100)
Amyloid Deposition 1 (1%) 1 (1%)
Angiectasis 1 (1%) 3 (3%) 2 (2%) 3 (3%)
Hemorrhage 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hydrometra 24 (26%) 18 (19%) 16 (16%) 20 (20%) 22 (22%)
Inflammation 2 (2%)
Inflammation, Chronic 1 (1%)
Thrombosis 1 (1%)
Bilateral, Atrophy 1 (1%)
Bilateral, Hydrometra 24 (26%) 15 (15%) 24 (24%) 21 (21%) 26 (26%)
Bilateral, Endometrium, Amyloid Deposition 1 (1%)
Bilateral, Endometrium, Hyperplasia, Cystic 32 (35%) 44 (45%) 41 (42%) 45 (45%) 38 (38%)
Cervix, Angiectasis 1 (1%)
Endometrium, Angiectasis 1 (1%)
Endometrium, Hyperplasia, Cystic 22 (24%) 27 (28%) 26 (27%) 21 (21%) 24 (24%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (96) (99) (97) (99) (100)
Angiectasis 1 (1%) 2 (2%)
Atrophy 1 (1%) 1 (1%)
Hyperplasia 23 (24%) 13 (13%) 13 (13%) 14 (14%) 19 (19%)
Infiltration Cellular, Focal, Lymphocyte 1 (1%)
Myelofibrosis 10 (10%) 18 (18%) 17 (18%) 10 (10%) 21 (21%)
Necrosis 1 (1%)
Myeloid Cell, Hyperplasia 3 (3%)
Lymph Node (19) (15) (4) (14) (12)
Ectasia 2 (11%) 2 (13%) 2 (50%) 1 (7%) 1 (8%)
Hemorrhage 1 (5%) 2 (13%) 1 (25%) 1 (7%) 1 (8%)
Hyperplasia, Reticulum Cell 1 (8%)
Infiltration Cellular, Mast Cell 1 (25%)
Infiltration Cellular, Histiocyte 1 (7%) 1 (8%)
Lumbar, Ectasia 3 (16%) 1 (7%) 1 (25%) 2 (14%)
Lumbar, Hemorrhage 4 (21%) 1 (25%) 1 (7%)
Lumbar, Pigmentation 1 (5%)
Mediastinal, Hemorrhage 1 (7%)
Mediastinal, Infiltration Cellular, Mixed
Cell 1 (7%)
Renal, Ectasia 1 (7%)
Lymph Node, Mandibular (84) (94) (89) (91) (92)
Atrophy 3 (4%) 7 (7%) 4 (4%) 4 (4%) 3 (3%)
Hemorrhage 2 (2%) 2 (2%) 1 (1%) 2 (2%) 3 (3%)
Hyperplasia 8 (10%) 10 (11%) 12 (13%) 4 (4%) 4 (4%)
Hyperplasia, Reticulum Cell 2 (2%) 1 (1%) 2 (2%) 2 (2%)
Infiltration Cellular, Plasma Cell 2 (2%) 1 (1%) 2 (2%) 1 (1%) 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%) 1 (1%)
Infiltration Cellular, Mixed Cell 2 (2%) 1 (1%) 2 (2%) 1 (1%) 1 (1%)
Pigmentation 22 (26%) 9 (10%) 18 (20%) 10 (11%) 18 (20%)
Lymph Node, Mesenteric (83) (88) (89) (92) (95)
Angiectasis 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Atrophy 12 (14%) 10 (11%) 24 (27%) 21 (23%) 22 (23%)
Ectasia 3 (4%) 4 (4%) 2 (2%)
Hemorrhage 3 (4%) 2 (2%) 4 (4%) 4 (4%) 2 (2%)
Hyperplasia 2 (2%) 1 (1%) 4 (4%) 2 (2%)
Hyperplasia, Reticulum Cell 3 (4%) 7 (8%) 13 (15%) 8 (9%) 15 (16%)
Infiltration Cellular, Plasma Cell 5 (6%) 4 (5%) 2 (2%) 1 (1%) 6 (6%)
Infiltration Cellular, Histiocyte 50 (60%) 45 (51%) 47 (53%) 43 (47%) 41 (43%)
Infiltration Cellular, Mixed Cell 4 (5%) 1 (1%) 2 (2%) 5 (5%) 5 (5%)
Inflammation, Focal 1 (1%)
Artery, Inflammation 1 (1%)
Spleen (91) (93) (95) (93) (99)
Congestion 1 (1%)
Fibrosis, Focal 1 (1%)
Hematopoietic Cell Proliferation 74 (81%) 77 (83%) 87 (92%) 83 (89%) 92 (93%)
Infarct 1 (1%) 1 (1%)
Infiltration Cellular, Mast Cell 1 (1%)
Infiltration Cellular, Plasma Cell 1 (1%)
Pigmentation 17 (19%) 6 (6%) 8 (8%) 12 (13%) 12 (12%)
Lymphoid Follicle, Atrophy 6 (7%) 4 (4%) 7 (7%) 3 (3%) 3 (3%)
Lymphoid Follicle, Hyperplasia 31 (34%) 31 (33%) 32 (34%) 34 (37%) 40 (40%)
Lymphoid Follicle, Necrosis 1 (1%) 1 (1%)
Red Pulp, Atrophy 2 (2%) 3 (3%)
Thymus (78) (92) (84) (75) (89)
Angiectasis 1 (1%) 2 (2%) 3 (4%) 3 (4%) 2 (2%)
Atrophy 22 (28%) 20 (22%) 24 (29%) 29 (39%) 27 (30%)
Cyst, Focal 5 (6%) 2 (2%) 3 (4%) 9 (12%) 3 (3%)
Hemorrhage 1 (1%) 2 (2%)
Hyperplasia, Lymphoid 31 (40%) 19 (21%) 20 (24%) 24 (32%) 25 (28%)
Artery, Inflammation 1 (1%)
Thymocyte, Necrosis 1 (1%) 3 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (94) (98) (99) (99) (98)
Hyperplasia 3 (3%) 3 (3%) 5 (5%) 2 (2%) 3 (3%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Artery, Inflammation 1 (1%)
Duct, Dilatation 10 (11%) 15 (15%) 16 (16%) 17 (17%) 12 (12%)
Skin (99) (100) (100) (100) (100)
Hemorrhage 1 (1%)
Ulcer, Focal 2 (2%)
Artery, Inflammation 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (7) (3) (3) (4) (4)
Degeneration 1 (33%)
Necrosis 1 (14%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (99) (100) (98) (98) (100)
Infiltration Cellular, Focal, Mixed Cell 1 (1%)
Artery, Inflammation 1 (1%)
Cerebellum, Developmental Malformation, Focal 1 (1%)
Choroid Plexus, Infiltration Cellular,
Lymphocyte 1 (1%)
Hypothalamus, Compression 2 (2%) 3 (3%) 3 (3%)
Hypothalamus, Hemorrhage 1 (1%)
Thalamus, Infiltration Cellular, Lymphocyte 1 (1%)
Thalamus, Mineralization 47 (47%) 68 (68%) 55 (56%) 60 (61%) 72 (72%)
Ventricle, Hydrocephalus 2 (2%)
Ventricle, Infiltration Cellular, Lymphocyte 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (95) (100) (99) (99) (100)
Congestion 1 (1%) 1 (1%)
Fibrosis 1 (1%)
Hemorrhage 2 (2%) 1 (1%) 1 (1%)
Infiltration Cellular, Lymphocyte 32 (34%) 37 (37%) 33 (33%) 34 (34%) 30 (30%)
Inflammation, Focal 2 (2%) 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Metaplasia, Focal, Osseous 1 (1%) 1 (1%)
Alveolar Epithelium, Hyperplasia, Focal 4 (4%) 1 (1%) 2 (2%) 1 (1%)
Alveolus, Infiltration Cellular, Histiocyte 1 (1%) 4 (4%) 1 (1%) 2 (2%)
Artery, Mineralization 2 (2%)
Serosa, Inflammation 2 (2%)
Trachea (94) (100) (98) (99) (98)
Artery, Inflammation 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (1) (1) (2)
Cornea, Inflammation 2 (100%) 1 (100%)
Lens, Degeneration 1 (50%)
Lens, Mineralization 1 (100%)
Harderian Gland (98) (97) (99) (96) (97)
Infiltration Cellular, Lymphocyte 13 (13%) 12 (12%) 18 (18%) 16 (17%) 20 (21%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Bilateral, Infiltration Cellular, Lymphocyte 14 (14%) 11 (11%) 18 (18%) 16 (17%) 16 (16%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (92) (96) (98) (98) (99)
Hydronephrosis 1 (1%) 1 (1%) 1 (1%)
Infarct, Acute 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Artery, Inflammation 1 (1%)
Bilateral, Artery, Inflammation 1 (1%)
Bilateral, Artery, Mineralization 1 (1%)
Bilateral, Artery, Cortex, Inflammation 1 (1%)
Bilateral, Cortex, Cyst, Multiple 1 (1%)
Bilateral, Cortex, Infiltration Cellular,
Lymphocyte 11 (12%) 8 (8%) 7 (7%) 7 (7%) 8 (8%)
Bilateral, Cortex, Inflammation 1 (1%)
Bilateral, Cortex, Mineralization 1 (1%) 1 (1%)
Bilateral, Cortex, Renal Tubule,
Accumulation, Hyaline Droplet 2 (2%) 3 (3%)
Bilateral, Cortex, Renal Tubule, Degeneration 7 (8%) 11 (11%) 7 (7%) 8 (8%) 9 (9%)
Bilateral, Cortex, Renal Tubule, Dilatation 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Bilateral, Cortex, Renal Tubule,
Vacuolization Cytoplasmic 2 (2%)
Bilateral, Glomerulus, Amyloid Deposition 1 (1%)
Bilateral, Glomerulus, Inflammation 1 (1%) 1 (1%)
Bilateral, Medulla, Infiltration Cellular,
Lymphocyte 26 (28%) 29 (30%) 38 (39%) 31 (32%) 37 (37%)
Bilateral, Medulla, Mineralization 1 (1%) 1 (1%)
Cortex, Cyst 3 (3%)
Cortex, Infiltration Cellular, Plasma Cell 1 (1%)
Cortex, Infiltration Cellular, Lymphocyte 13 (14%) 9 (9%) 14 (14%) 8 (8%) 8 (8%)
Cortex, Infiltration Cellular, Mixed Cell 1 (1%)
Cortex, Metaplasia, Focal, Osseous 4 (4%) 3 (3%) 3 (3%) 3 (3%) 3 (3%)
Cortex, Necrosis 1 (1%)
Cortex, Renal Tubule, Degeneration 3 (3%) 7 (7%) 4 (4%) 4 (4%) 4 (4%)
Cortex, Renal Tubule, Dilatation 2 (2%)
Medulla, Cyst 1 (1%)
Medulla, Infiltration Cellular, Lymphocyte 21 (23%) 24 (25%) 18 (18%) 27 (28%) 20 (20%)
Medulla, Inflammation 1 (1%) 1 (1%)
Medulla, Mineralization 2 (2%) 1 (1%) 1 (1%) 1 (1%)
Pelvis, Calculus Micro Observation Only 3 (3%) 2 (2%) 2 (2%) 1 (1%) 2 (2%)
Urinary Bladder (79) (87) (94) (89) (92)
Infiltration Cellular, Plasma Cell 1 (1%)
Infiltration Cellular, Lymphocyte 8 (10%) 3 (3%) 4 (4%) 6 (7%) 5 (5%)
Arteriole, Inflammation 1 (1%) 1 (1%)
Artery, Inflammation 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Serosa, Inflammation, Chronic Active 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 100 100 100 100 100
Early Deaths
Natural Death 13 15 10 24 18
Moribund Sacrifice 11 13 6 14 8
Survivors
Terminal Sacrifice 76 72 84 62 73
Natural Death 1
Animals Examined Microscopically 100 100 100 100 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (84) (83) (84) (75) (82)
Congestion 1 (1%)
Inflammation, Granulomatous 1 (1%)
Epithelium, Cyst 4 (5%) 2 (2%) 2 (3%) 2 (2%)
Epithelium, Hyperplasia, Focal 1 (1%)
Intestine Large, Colon (93) (94) (92) (83) (85)
Lymphoid Tissue, Hyperplasia 1 (1%)
Muscularis, Hypertrophy 1 (1%)
Intestine Large, Rectum (93) (90) (93) (81) (87)
Lymphoid Tissue, Hyperplasia 1 (1%)
Intestine Large, Cecum (90) (89) (92) (81) (85)
Inflammation 1 (1%) 1 (1%)
Lymphoid Tissue, Hyperplasia 41 (46%) 33 (37%) 37 (40%) 20 (25%) 46 (54%)
Serosa, Fibrosis 1 (1%)
Intestine Small, Duodenum (89) (88) (92) (79) (84)
Infiltration Cellular, Histiocyte 1 (1%)
Muscularis, Inflammation 1 (1%)
Peyer's Patch, Hyperplasia 2 (2%) 1 (1%)
Intestine Small, Jejunum (89) (94) (93) (80) (85)
Inflammation 1 (1%) 1 (1%)
Epithelium, Hyperplasia, Focal 1 (1%)
Muscularis, Hypertrophy 3 (3%) 1 (1%) 2 (2%)
Peyer's Patch, Hyperplasia 1 (1%) 5 (5%) 1 (1%) 1 (1%)
Serosa, Inflammation 1 (1%)
Intestine Small, Ileum (91) (89) (92) (81) (84)
Inflammation 1 (1%)
Epithelium, Degeneration 1 (1%)
Muscularis, Hypertrophy 9 (10%) 8 (9%) 7 (8%)
Peyer's Patch, Hyperplasia 1 (1%) 1 (1%)
Serosa, Inflammation 1 (1%)
Liver (100) (100) (100) (98) (99)
Basophilic Focus 2 (2%) 2 (2%)
Clear Cell Focus 7 (7%) 9 (9%) 9 (9%) 7 (7%) 9 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Clear Cell Focus, Multiple 7 (7%) 9 (9%) 6 (6%) 4 (4%) 5 (5%)
Congestion 1 (1%)
Eosinophilic Focus 10 (10%) 12 (12%) 11 (11%) 14 (14%) 15 (15%)
Eosinophilic Focus, Multiple 2 (2%) 1 (1%) 4 (4%) 1 (1%) 1 (1%)
Hematopoietic Cell Proliferation 1 (1%)
Hepatodiaphragmatic Nodule 2 (2%)
Infiltration Cellular, Focal, Mixed Cell 6 (6%) 10 (10%) 14 (14%) 10 (10%) 11 (11%)
Inflammation, Focal 1 (1%)
Inflammation, Granulomatous 1 (1%)
Metaplasia, Focal, Osseous 1 (1%)
Mixed Cell Focus 4 (4%) 1 (1%) 3 (3%) 4 (4%) 3 (3%)
Necrosis 7 (7%) 6 (6%) 4 (4%) 4 (4%) 3 (3%)
Pigmentation 1 (1%)
Thrombosis, Focal 1 (1%)
Bile Duct, Cyst 2 (2%) 1 (1%)
Hepatocyte, Vacuolization Cytoplasmic 13 (13%) 9 (9%) 6 (6%) 6 (6%) 5 (5%)
Hepatocyte, Centrilobular, Hypertrophy 1 (1%)
Sinusoid, Centrilobular, Dilatation 1 (1%)
Mesentery (13) (16) (8) (10) (9)
Infiltration Cellular, Histiocyte 1 (8%)
Inflammation 1 (6%) 1 (10%)
Artery, Inflammation 1 (8%) 1 (6%) 1 (13%)
Fat, Inflammation 1 (8%) 3 (19%) 2 (25%)
Fat, Necrosis 11 (85%) 11 (69%) 4 (50%) 6 (60%) 7 (78%)
Pancreas (99) (99) (98) (95) (98)
Cytoplasmic Alteration 1 (1%)
Infiltration Cellular, Focal, Mixed Cell 1 (1%) 1 (1%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%) 4 (4%) 2 (2%) 5 (5%)
Inflammation 1 (1%)
Lipomatosis 1 (1%) 11 (11%) 14 (14%) 1 (1%) 4 (4%)
Necrosis 1 (1%)
Vacuolization Cytoplasmic 16 (16%) 31 (31%) 28 (29%) 5 (5%) 28 (29%)
Acinus, Atrophy 1 (1%) 1 (1%) 2 (2%)
Acinus, Cytoplasmic Alteration 1 (1%) 3 (3%) 4 (4%)
Acinus, Degeneration 1 (1%)
Acinus, Hypertrophy, Focal 1 (1%) 1 (1%)
Duct, Cyst 2 (2%) 1 (1%) 1 (1%) 2 (2%)
Salivary Glands (99) (99) (98) (96) (99)
Atrophy 1 (1%) 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Infiltration Cellular, Lymphocyte 66 (67%) 65 (66%) 72 (73%) 61 (64%) 69 (70%)
Vacuolization Cytoplasmic 1 (1%)
Stomach, Forestomach (99) (98) (97) (96) (99)
Diverticulum 1 (1%)
Inflammation, Focal 1 (1%) 1 (1%)
Epithelium, Atrophy 9 (9%) 10 (10%) 8 (8%) 7 (7%) 8 (8%)
Epithelium, Hyperplasia 3 (3%) 1 (1%)
Epithelium, Hyperplasia, Focal 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Epithelium, Vacuolization Cytoplasmic 1 (1%)
Stomach, Glandular (94) (93) (97) (87) (93)
Erosion, Focal 1 (1%)
Inflammation 3 (3%) 1 (1%) 1 (1%)
Epithelium, Atrophy 8 (9%) 9 (10%) 8 (8%) 8 (9%) 10 (11%)
Epithelium, Cyst, Focal 6 (6%) 10 (11%) 10 (10%) 3 (3%) 11 (12%)
Epithelium, Hyperplasia, Focal 1 (1%)
Epithelium, Mineralization 1 (1%) 1 (1%)
Serosa, Inflammation 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (97) (94) (100) (96) (98)
Aorta, Mineralization 1 (1%) 1 (1%)
Heart (100) (100) (100) (99) (100)
Inflammation, Focal 2 (2%) 1 (1%) 5 (5%) 2 (2%) 2 (2%)
Arteriole, Inflammation 1 (1%)
Arteriole, Mineralization 1 (1%)
Artery, Inflammation 1 (1%) 1 (1%)
Artery, Mineralization 1 (1%) 1 (1%)
Atrium, Infiltration Cellular 1 (1%)
Atrium, Thrombosis 1 (1%)
Capillary, Myocardium, Infiltration Cellular,
Focal 1 (1%)
Epicardium, Mineralization 1 (1%) 1 (1%)
Myocardium, Degeneration 2 (2%) 2 (2%)
Myocardium, Mineralization 1 (1%)
Myocardium, Necrosis, Focal 1 (1%)
Valve, Thrombosis 2 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (99) (96) (99) (94) (97)
Bilateral, Mineralization 1 (1%)
Bilateral, Capsule, Hyperplasia 55 (56%) 52 (54%) 53 (54%) 50 (53%) 52 (54%)
Bilateral, Capsule, Mineralization 1 (1%) 1 (1%)
Bilateral, Zona Fasciculata, Hyperplasia,
Focal 1 (1%) 1 (1%)
Bilateral, Zona Fasciculata, Hypertrophy 1 (1%) 2 (2%) 2 (2%)
Bilateral, Zona Fasciculata, Hypertrophy,
Focal 2 (2%) 3 (3%) 6 (6%) 2 (2%) 3 (3%)
Capsule, Hyperplasia 31 (31%) 31 (32%) 38 (38%) 31 (33%) 33 (34%)
Zona Fasciculata, Degeneration, Focal 1 (1%)
Zona Fasciculata, Hyperplasia, Focal 3 (3%) 6 (6%) 7 (7%) 2 (2%) 5 (5%)
Zona Fasciculata, Hypertrophy 8 (8%) 14 (15%) 11 (11%) 7 (7%) 5 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Zona Fasciculata, Hypertrophy, Focal 13 (13%) 17 (18%) 15 (15%) 10 (11%) 16 (16%)
Zona Fasciculata, Infiltration Cellular,
Polymorphonuclear 1 (1%)
Zona Fasciculata, Vacuolization Cytoplasmic 2 (2%)
Zona Fasciculata, Vacuolization Cytoplasmic,
Focal 1 (1%)
Zona Glomerulosa, Hyperplasia, Focal 3 (3%) 7 (7%) 4 (4%) 2 (2%) 7 (7%)
Zona Reticularis, Degeneration, Fatty 1 (1%) 1 (1%)
Adrenal Medulla (98) (93) (99) (91) (96)
Angiectasis 1 (1%)
Hyperplasia 2 (2%) 3 (3%) 3 (3%) 5 (5%)
Islets, Pancreatic (99) (99) (98) (97) (98)
Hyperplasia 97 (98%) 88 (89%) 84 (86%) 84 (87%) 89 (91%)
Hypertrophy, Focal 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%) 1 (1%)
Parathyroid Gland (66) (55) (72) (65) (67)
Cyst 1 (2%) 1 (1%) 1 (2%) 2 (3%)
Hyperplasia 1 (2%) 2 (4%) 2 (3%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%)
Infiltration Cellular, Mixed Cell 1 (2%)
Pituitary Gland (83) (84) (82) (84) (86)
Pars Distalis, Cyst 9 (11%) 7 (8%) 6 (7%) 4 (5%) 14 (16%)
Pars Distalis, Hyperplasia, Focal 1 (1%) 2 (2%) 1 (1%) 3 (4%) 1 (1%)
Pars Nervosa, Cyst 1 (1%)
Thyroid Gland (99) (98) (98) (97) (98)
Bilateral, Follicle, Cyst 1 (1%)
Follicle, Cyst 5 (5%) 13 (13%) 7 (7%) 7 (7%) 9 (9%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (4) (1) (1)
Inflammation, Acute 1 (25%)
Abdominal, Fat, Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2) (2) (1)
Cyst 1 (50%) 1 (50%) 1 (100%)
Bilateral, Cyst 1 (50%)
Epididymis (98) (99) (99) (96) (98)
Cyst 1 (1%)
Granuloma Sperm 2 (2%) 2 (2%) 1 (1%) 2 (2%)
Hyperplasia 1 (1%)
Infiltration Cellular, Lymphocyte 13 (13%) 9 (9%) 16 (16%) 14 (15%) 15 (15%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation 2 (2%)
Inflammation, Granulomatous 1 (1%)
Spermatocele 2 (2%) 3 (3%) 7 (7%) 6 (6%)
Bilateral, Atrophy 1 (1%)
Bilateral, Granuloma Sperm 1 (1%) 1 (1%)
Bilateral, Infiltration Cellular, Lymphocyte 11 (11%) 2 (2%) 5 (5%) 4 (4%) 9 (9%)
Preputial Gland (98) (98) (100) (95) (99)
Atrophy 8 (8%) 22 (22%) 15 (15%) 10 (11%) 18 (18%)
Cyst 29 (30%) 13 (13%) 7 (7%) 23 (24%) 17 (17%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Inflammation 15 (15%) 18 (18%) 33 (33%) 27 (28%) 34 (34%)
Bilateral, Atrophy 17 (17%) 34 (35%) 34 (34%) 27 (28%) 38 (38%)
Bilateral, Cyst 55 (56%) 75 (77%) 86 (86%) 53 (56%) 72 (73%)
Bilateral, Inflammation 31 (32%) 19 (19%) 23 (23%) 26 (27%) 27 (27%)
Bilateral, Mineralization 1 (1%)
Prostate (98) (92) (94) (94) (92)
Atrophy 1 (1%)
Infiltration Cellular, Lymphocyte 2 (2%) 4 (4%) 4 (4%) 2 (2%) 6 (7%)
Inflammation 1 (1%) 1 (1%)
Epithelium, Hyperplasia 49 (50%) 52 (57%) 56 (60%) 47 (50%) 45 (49%)
Seminal Vesicle (99) (97) (98) (98) (98)
Atrophy 2 (2%) 1 (1%)
Cyst 28 (28%) 22 (23%) 23 (23%) 19 (19%) 16 (16%)
Infiltration Cellular, Lymphocyte 1 (1%)
Inflammation 2 (2%) 2 (2%)
Bilateral, Atrophy 1 (1%) 1 (1%)
Bilateral, Cyst 52 (53%) 41 (42%) 36 (37%) 49 (50%) 42 (43%)
Bilateral, Inflammation 1 (1%)
Testes (99) (98) (100) (96) (98)
Atrophy 3 (3%) 3 (3%) 1 (1%) 2 (2%) 1 (1%)
Hemorrhage, Focal 1 (1%)
Mineralization 1 (1%) 1 (1%) 1 (1%)
Necrosis 1 (1%)
Bilateral, Atrophy 2 (2%) 6 (6%) 1 (1%)
Interstitial Cell, Hyperplasia, Focal 1 (1%)
Tunic, Inflammation 1 (1%)
Tunic, Mineralization 1 (1%) 1 (1%) 1 (1%)
Tunic, Mineralization, Focal 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (99) (99) (99) (99) (100)
Atrophy 1 (1%) 1 (1%) 3 (3%)
Fibrosis 1 (1%)
Hyperplasia 33 (33%) 30 (30%) 28 (28%) 30 (30%) 25 (25%)
Infiltration Cellular, Focal, Lymphocyte 3 (3%) 1 (1%) 2 (2%) 2 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Myelofibrosis 1 (1%) 2 (2%) 2 (2%)
Necrosis 1 (1%)
Thrombosis 1 (1%)
Erythroid Cell, Atrophy 1 (1%)
Myeloid Cell, Hyperplasia 2 (2%) 3 (3%) 5 (5%)
Lymph Node (6) (6) (5) (3) (7)
Inflammation, Focal 1 (17%)
Inguinal, Hemorrhage 1 (20%)
Inguinal, Hyperplasia 1 (20%)
Inguinal, Necrosis 1 (20%)
Lumbar, Hemorrhage 1 (17%)
Lumbar, Hyperplasia 1 (14%)
Lumbar, Infiltration Cellular, Plasma Cell 1 (17%)
Lymph Node, Mandibular (92) (92) (92) (89) (90)
Atrophy 4 (4%) 2 (2%) 3 (3%) 4 (4%) 1 (1%)
Hemorrhage 1 (1%) 1 (1%)
Hyperplasia 1 (1%) 4 (4%) 1 (1%) 1 (1%) 3 (3%)
Infiltration Cellular, Mast Cell 1 (1%) 1 (1%) 7 (8%) 2 (2%)
Infiltration Cellular, Plasma Cell 2 (2%) 3 (3%) 2 (2%) 1 (1%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%) 3 (3%)
Infiltration Cellular, Mixed Cell 4 (4%) 2 (2%) 3 (3%) 1 (1%)
Necrosis 1 (1%)
Pigmentation 2 (2%) 4 (4%) 3 (3%) 2 (2%) 4 (4%)
Lymph Node, Mesenteric (87) (90) (96) (85) (92)
Atrophy 6 (7%) 12 (13%) 14 (15%) 7 (8%) 12 (13%)
Hematopoietic Cell Proliferation 1 (1%)
Hemorrhage 3 (3%) 2 (2%) 3 (3%) 3 (4%) 5 (5%)
Hyperplasia 7 (8%) 5 (5%) 1 (1%) 3 (3%)
Infiltration Cellular, Plasma Cell 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Infiltration Cellular, Histiocyte 59 (68%) 67 (74%) 79 (82%) 56 (66%) 72 (78%)
Infiltration Cellular, Mixed Cell 3 (3%) 5 (6%) 2 (2%) 3 (4%) 6 (7%)
Necrosis 1 (1%)
Pigmentation 1 (1%)
Artery, Inflammation 1 (1%)
Spleen (99) (98) (98) (93) (98)
Hematopoietic Cell Proliferation 37 (37%) 43 (44%) 52 (53%) 36 (39%) 48 (49%)
Pigmentation 1 (1%) 1 (1%)
Capsule, Degeneration, Focal 1 (1%)
Lymphoid Follicle, Atrophy 11 (11%) 12 (12%) 8 (8%) 14 (15%) 8 (8%)
Lymphoid Follicle, Hyperplasia 21 (21%) 27 (28%) 17 (17%) 13 (14%) 19 (19%)
Red Pulp, Atrophy 4 (4%) 3 (3%) 4 (4%) 4 (4%)
Red Pulp, Pigmentation 1 (1%)
Thymus (69) (68) (63) (68) (60)
Atrophy 62 (90%) 50 (74%) 47 (75%) 64 (94%) 44 (73%)
Cyst, Focal 4 (6%) 10 (15%) 9 (14%) 4 (6%) 5 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (1%) 1 (2%)
Hyperplasia, Lymphoid 3 (4%) 5 (7%) 9 (14%) 5 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (2) (1) (3) (4) (1)
Hyperplasia 1 (33%)
Duct, Dilatation 1 (25%)
Skin (99) (99) (100) (100) (100)
Cyst 1 (1%) 1 (1%)
Inflammation 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Ulcer, Focal 1 (1%) 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (97) (100) (99) (99) (99)
Cartilage, Epiphysis, Femur, Cyst 1 (1%)
Cartilage, Epiphysis, Femur, Cyst, Multiple 1 (1%)
Femur, Fibrous Osteodystrophy 1 (1%)
Vertebra, Inflammation 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (99) (100) (99) (100)
Hydrocephalus 1 (1%)
Cerebellum, Developmental Malformation 1 (1%)
Cerebellum, Hemorrhage 1 (1%)
Cerebrum, Vacuolization Cytoplasmic, Focal 1 (1%)
Thalamus, Mineralization 70 (70%) 68 (69%) 60 (60%) 78 (79%) 63 (63%)
Thalamus, Vacuolization Cytoplasmic, Focal 1 (1%)
Peripheral Nerve (7) (8) (2) (6) (3)
Sciatic, Degeneration 1 (13%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (100) (99) (100) (99) (99)
Congestion 1 (1%) 2 (2%)
Infiltration Cellular, Lymphocyte 21 (21%) 16 (16%) 22 (22%) 24 (24%) 16 (16%)
Inflammation, Focal 3 (3%) 1 (1%) 3 (3%) 2 (2%)
Mineralization, Focal 1 (1%)
Alveolar Epithelium, Hyperplasia, Focal 2 (2%) 2 (2%) 3 (3%) 2 (2%)
Alveolus, Infiltration Cellular, Histiocyte 3 (3%) 5 (5%) 4 (4%) 3 (3%) 9 (9%)
Arteriole, Thrombosis 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Serosa, Inflammation 1 (1%)
Nose (99) (99) (100) (97) (100)
Inflammation 1 (1%) 2 (2%) 3 (3%) 2 (2%) 7 (7%)
Sinus, Inflammation 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (1)
Atrophy 1 (50%)
Cornea, Inflammation 1 (50%)
Harderian Gland (99) (99) (100) (96) (99)
Atrophy, Focal 1 (1%) 1 (1%)
Infiltration Cellular, Lymphocyte 8 (8%) 11 (11%) 10 (10%) 4 (4%) 9 (9%)
Inflammation 1 (1%)
Inflammation, Focal 1 (1%) 1 (1%) 1 (1%)
Necrosis, Focal 1 (1%)
Bilateral, Infiltration Cellular, Lymphocyte 3 (3%) 2 (2%) 6 (6%) 5 (5%) 5 (5%)
Epithelium, Hypertrophy, Focal 1 (1%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (99) (98) (99) (96) (97)
Hydronephrosis 1 (1%) 1 (1%)
Infarct, Focal 1 (1%) 3 (3%) 1 (1%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (1%) 1 (1%)
Arteriole, Inflammation 1 (1%)
Artery, Inflammation 1 (1%)
Bilateral, Hydronephrosis 1 (1%) 2 (2%)
Bilateral, Infarct, Focal 1 (1%)
Bilateral, Artery, Inflammation 1 (1%) 1 (1%)
Bilateral, Capsule, Mineralization 1 (1%)
Bilateral, Cortex, Congestion 2 (2%) 2 (2%)
Bilateral, Cortex, Cyst 4 (4%) 7 (7%) 6 (6%) 6 (6%) 2 (2%)
Bilateral, Cortex, Infiltration Cellular,
Lymphocyte 10 (10%) 8 (8%) 8 (8%) 10 (10%) 19 (20%)
Bilateral, Cortex, Inflammation 1 (1%)
Bilateral, Cortex, Mineralization 79 (80%) 78 (80%) 77 (78%) 66 (69%) 74 (76%)
Bilateral, Cortex, Renal Tubule, Degeneration 72 (73%) 75 (77%) 76 (77%) 57 (59%) 71 (73%)
Bilateral, Cortex, Renal Tubule, Dilatation 2 (2%) 1 (1%) 1 (1%) 5 (5%) 2 (2%)
Bilateral, Cortex, Renal Tubule, Pigmentation 1 (1%) 2 (2%) 2 (2%) 1 (1%)
Bilateral, Medulla, Infiltration Cellular,
Lymphocyte 34 (34%) 26 (27%) 37 (37%) 26 (27%) 38 (39%)
Bilateral, Medulla, Inflammation 1 (1%) 1 (1%)
Bilateral, Medulla, Mineralization 1 (1%) 1 (1%)
Bilateral, Papilla, Necrosis 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 89029-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/09/98
Route: MAGNETIC FIELDS Time: 12:39:32
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B6C3F1 MICE MALE SHAM .02 2 GAUSS 10 10 GAUSS
CONTROL GAUSS GAUSS INTER
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URINARY SYSTEM - CONT
Cortex, Cyst 19 (19%) 23 (23%) 21 (21%) 11 (11%) 20 (21%)
Cortex, Degeneration, Focal 1 (1%) 1 (1%)
Cortex, Infiltration Cellular, Focal, Mixed
Cell 1 (1%)
Cortex, Infiltration Cellular, Lymphocyte 9 (9%) 10 (10%) 13 (13%) 6 (6%) 18 (19%)
Cortex, Inflammation 1 (1%) 2 (2%)
Cortex, Metaplasia, Focal, Osseous 4 (4%) 4 (4%) 8 (8%) 2 (2%) 4 (4%)
Cortex, Mineralization 1 (1%) 3 (3%)
Cortex, Renal Tubule, Degeneration 4 (4%) 2 (2%) 2 (2%) 1 (1%) 1 (1%)
Cortex, Renal Tubule, Dilatation 1 (1%) 2 (2%)
Glomerulus, Inflammation, Focal 1 (1%)
Medulla, Infiltration Cellular, Lymphocyte 21 (21%) 14 (14%) 19 (19%) 15 (16%) 9 (9%)
Medulla, Inflammation 1 (1%) 1 (1%)
Medulla, Mineralization 1 (1%)
Urethra (1)
Cyst 1 (100%)
Urinary Bladder (98) (95) (95) (93) (94)
Hemorrhage 1 (1%)
Infiltration Cellular, Lymphocyte 4 (4%) 1 (1%) 1 (1%) 4 (4%)
Inflammation 1 (1%) 1 (1%)
Artery, Inflammation 1 (1%)
Transitional Epithelium, Hyperplasia 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
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