TDMS Study 89029-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98 EXPERIMENT: 89029 TEST: 06 TIME: 08:58:57 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98 EXPERIMENT: 89029 TEST: 06 TIME: 08:58:57 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF MAGNETIC FIELDS (EMF) =============================================================== Male Mice ------------ Organ Morphology ----- ---------- Brain: Thalamus Mineralization Epididymis Infiltration Cellular Lymphocyte Spermatocele Intestine Large, Cecum: Lymphoid Tissue Hyperplasia Intestine Small, Ileum: Muscularis Hypertrophy Islets, Pancreatic Hyperplasia Kidney: Cortex Cyst Mineralization Kidney: Cortex, Renal Tubule Degeneration Dilatation Kidney: Medulla Infiltration Cellular Lymphocyte Liver Hepatodiaphragmatic Nodule Infiltration Cellular Focal Mixed Cell Liver: Hepatocyte Vacuolization Cytoplasmic Lung Infiltration Cellular Lymphocyte Lymph Node, Mandibular Infiltration Cellular Mast Cell Lymph Node, Mesenteric Hyperplasia Infiltration Cellular Histiocyte Pancreas Lipomatosis Vacuolization Cytoplasmic Preputial Gland Atrophy Cyst Inflammation Seminal Vesicle Atrophy Cyst Spleen Hematopoietic Cell Proliferation Spleen: Lymphoid Follicle Hyperplasia Spleen: Red Pulp Atrophy Testes Atrophy Thymus Atrophy Hyperplasia Lymphoid Thyroid Gland: Follicle Cyst =============================================================== Female Mice ------------ Organ Morphology ----- ---------- Adrenal Cortex: Zona Fasciculata Hypertrophy Focal Adrenal Medulla Hyperplasia Bone Marrow Hyperplasia Brain: Thalamus Mineralization Clitoral Gland Cyst NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98 EXPERIMENT: 89029 TEST: 06 TIME: 08:58:57 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG Gallbladder: Epithelium Cyst Intestine Small, Jejunum: Peyer's Patch Hyperplasia Islets, Pancreatic Hyperplasia Kidney: Cortex Cyst Infiltration Cellular Lymphocyte Liver Necrosis Lung: Alveolar Epithelium Hyperplasia Focal Lymph Node, Mandibular Pigmentation Lymph Node, Mesenteric Atrophy Hyperplasia Reticulum Cell Pancreas Infiltration Cellular Lymphocyte Lipomatosis Spleen Hematopoietic Cell Proliferation Pigmentation Stomach, Glandular Infiltration Cellular Lymphocyte Stomach, Glandular: Epithelium Cyst Focal Thymus Atrophy Cyst Focal Hyperplasia Lymphoid Uterus Hydrometra Uterus: Endometrium Hyperplasia Cystic =============================================================== Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 1 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Cortex: Capsule | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 86/99 (87%) 83/96 (86%) 91/99 (92%) 81/94 (86%) |91/92 (99%) 96/98 (98%) 97/99 (98%) 98/99 (99%) | |POLY-3 ADJUSTED (b)| 88.5% 88.8% 92.5% 88.6% |99.0% 98.0% 99.0% 100.0% | |TERMINAL (d) | 69/76 (91%) 63/71 (89%) 78/84 (93%) 54/61 (89%) |70/70 (100%) 73/74 (99%) 78/79 (99%) 74/74 (100%) | |FIRST INCIDENCE | 386 400 430 448 |334 64 472 85 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.052 P=0.417 P=0.400N P=0.092 |P=0.329 P=0.504 P=0.375N P=0.389 | |POLY 3 | P=0.505N P=0.573 P=0.232 P=0.586 |P=0.240 P=0.527N P=0.767N P=0.521 | |POLY 1.5 | P=0.486N P=0.587 P=0.207 P=0.581N |P=0.265 P=0.525N P=0.758 P=0.550 | |POLY 6 | P=0.507N P=0.570 P=0.270 P=0.593 |P=0.245 P=0.533N P=0.759N P=0.543 | |LOGISTIC REGRESSION| P=0.525N P=0.555 P=0.179 P=0.544 |P=0.372 P=0.511N P=0.674N P=0.578 | |COCH-ARM / FISHERS | P=0.437N P=0.550N P=0.178 P=0.527N |P=0.486 P=0.524N P=0.528N P=0.733 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Cortex: Zona Fasciculata | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/99 (4%) 7/96 (7%) 7/99 (7%) 2/94 (2%) |0/92 (0%) 0/98 (0%) 1/99 (1%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 4.3% 8.1% 7.6% 2.4% |0.0% 0.0% 1.1% 0.0% | |TERMINAL (d) | 3/76 (4%) 7/71 (10%) 7/84 (8%) 1/61 (2%) |0/70 (0%) 0/74 (0%) 1/79 (1%) 0/74 (0%) | |FIRST INCIDENCE | 717 734 (T) 734 (T) 718 |--- --- 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.180N P=0.232 P=0.326 P=0.432N |P=0.766N (e) P=0.524 (e) | |POLY 3 | P=0.146N P=0.231 P=0.270 P=0.395N |P=0.765N (e) P=0.510 (e) | |POLY 1.5 | P=0.136N P=0.239 P=0.269 P=0.382N |P=0.764N (e) P=0.512 (e) | |POLY 6 | P=0.157N P=0.221 P=0.275 P=0.408N |P=0.765N (e) P=0.508 (e) | |LOGISTIC REGRESSION| P=0.161N P=0.219 P=0.292 P=0.416N |(e) (e) P=0.524 (e) | |COCH-ARM / FISHERS | P=0.123N P=0.251 P=0.269 P=0.366N |P=0.761N (e) P=0.518 (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 2 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Cortex: Zona Fasciculata | | Hypertrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/99 (9%) 14/96 (15%) 13/99 (13%) 9/94 (10%) |0/92 (0%) 0/98 (0%) 0/99 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 9.8% 16.3% 13.9% 11.0% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 9/76 (12%) 14/71 (20%) 11/84 (13%) 9/61 (15%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 734 (T) 734 (T) 449 734 (T) |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.494N P=0.139 P=0.325 P=0.403 |(e) (e) (e) (e) | |POLY 3 | P=0.384N P=0.143 P=0.263 P=0.494 |(e) (e) (e) (e) | |POLY 1.5 | P=0.359N P=0.153 P=0.257 P=0.517 |(e) (e) (e) (e) | |POLY 6 | P=0.413N P=0.133 P=0.273 P=0.468 |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.400N P=0.139 P=0.250 P=0.403 |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.321N P=0.167 P=0.249 P=0.552 |(e) (e) (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Cortex: Zona Fasciculata | | Hypertrophy Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 15/99 (15%) 20/96 (21%) 21/99 (21%) 12/94 (13%) |2/92 (2%) 0/98 (0%) 3/99 (3%) 5/99 (5%) | |POLY-3 ADJUSTED (b)| 16.3% 23.0% 22.5% 14.6% |2.3% 0.0% 3.3% 5.6% | |TERMINAL (d) | 14/76 (18%) 17/71 (24%) 20/84 (24%) 10/61 (16%) |2/70 (3%) 0/74 (0%) 2/79 (3%) 5/74 (7%) | |FIRST INCIDENCE | 683 618 527 690 |735 (T) --- 721 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.287N P=0.165 P=0.270 P=0.570N |P=0.045 * P=0.227N P=0.547 P=0.243 | |POLY 3 | P=0.187N P=0.170 P=0.186 P=0.465N |P=0.046 * P=0.232N P=0.523 P=0.233 | |POLY 1.5 | P=0.166N P=0.181 P=0.182 P=0.436N |P=0.047 * P=0.230N P=0.526 P=0.237 | |POLY 6 | P=0.213N P=0.159 P=0.193 P=0.497N |P=0.046 * P=0.234N P=0.518 P=0.231 | |LOGISTIC REGRESSION| P=0.202N P=0.150 P=0.188 P=0.525N |P=0.046 * (e) P=0.516 P=0.243 | |COCH-ARM / FISHERS | P=0.137N P=0.199 P=0.179 P=0.394N |P=0.049 * P=0.233N P=0.535 P=0.254 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 3 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Cortex: Zona Fasciculata | | Vacuolization Cytoplasmic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/96 (0%) 0/99 (0%) 0/94 (0%) |0/92 (0%) 0/98 (0%) 0/99 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 2.2% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 2/76 (3%) 0/71 (0%) 0/84 (0%) 0/61 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 734 (T) --- --- --- |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.403N P=0.254N P=0.217N P=0.289N |(e) (e) (e) (e) | |POLY 3 | P=0.373N P=0.253N P=0.237N P=0.265N |(e) (e) (e) (e) | |POLY 1.5 | P=0.373N P=0.250N P=0.238N P=0.259N |(e) (e) (e) (e) | |POLY 6 | P=0.374N P=0.257N P=0.235N P=0.272N |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.403N (e) (e) (e) |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.372N P=0.256N P=0.249N P=0.262N |(e) (e) (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Cortex: Zona Glomerulosa | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 7/96 (7%) 4/99 (4%) 2/94 (2%) |0/92 (0%) 0/98 (0%) 1/99 (1%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 3.2% 8.1% 4.3% 2.4% |0.0% 0.0% 1.1% 0.0% | |TERMINAL (d) | 1/76 (1%) 5/71 (7%) 3/84 (4%) 2/61 (3%) |0/70 (0%) 0/74 (0%) 1/79 (1%) 0/74 (0%) | |FIRST INCIDENCE | 579 592 556 734 (T) |--- --- 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.232N P=0.146 P=0.535 P=0.581N |P=0.766N (e) P=0.524 (e) | |POLY 3 | P=0.205N P=0.139 P=0.503 P=0.556N |P=0.765N (e) P=0.510 (e) | |POLY 1.5 | P=0.193N P=0.144 P=0.501 P=0.543N |P=0.764N (e) P=0.512 (e) | |POLY 6 | P=0.219N P=0.133 P=0.507 P=0.570N |P=0.765N (e) P=0.508 (e) | |LOGISTIC REGRESSION| P=0.172N P=0.157 P=0.498 P=0.519N |(e) (e) P=0.524 (e) | |COCH-ARM / FISHERS | P=0.176N P=0.153 P=0.500 P=0.525N |P=0.761N (e) P=0.518 (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 4 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Cortex: Zona Reticularis | | Degeneration Fatty | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 1/96 (1%) 0/99 (0%) 0/94 (0%) |4/92 (4%) 2/98 (2%) 7/99 (7%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 1.1% 1.2% 0.0% 0.0% |4.6% 2.2% 7.6% 0.0% | |TERMINAL (d) | 0/76 (0%) 1/71 (1%) 0/84 (0%) 0/61 (0%) |4/70 (6%) 2/74 (3%) 5/79 (6%) 0/74 (0%) | |FIRST INCIDENCE | 683 734 (T) --- --- |735 (T) 735 (T) 654 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.395N P=0.741 P=0.500N P=0.530N |P=0.072N P=0.314N P=0.325 P=0.058N | |POLY 3 | P=0.382N P=0.745 P=0.499N P=0.524N |P=0.072N P=0.327N P=0.299 P=0.059N | |POLY 1.5 | P=0.379N P=0.749 P=0.500N P=0.518N |P=0.071N P=0.322N P=0.303 P=0.058N | |POLY 6 | P=0.386N P=0.741 P=0.498N P=0.530N |P=0.072N P=0.330N P=0.295 P=0.060N | |LOGISTIC REGRESSION| P=0.375N P=0.754 P=0.501N P=0.495N |P=0.072N P=0.314N P=0.299 (e) | |COCH-ARM / FISHERS | P=0.373N P=0.744 P=0.500N P=0.513N |P=0.068N P=0.312N P=0.312 P=0.052N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Medulla | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 2/93 (2%) 3/99 (3%) 3/91 (3%) |3/90 (3%) 8/95 (8%) 2/97 (2%) 0/97 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.4% 3.2% 3.7% |3.5% 9.3% 2.2% 0.0% | |TERMINAL (d) | 0/76 (0%) 2/68 (3%) 3/84 (4%) 2/61 (3%) |3/70 (4%) 7/73 (10%) 2/79 (3%) 0/73 (0%) | |FIRST INCIDENCE | --- 734 (T) 734 (T) 483 |735 (T) 705 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.175 P=0.215 P=0.141 P=0.097 |P=0.016N* P=0.120 P=0.445N P=0.115N | |POLY 3 | P=0.204 P=0.218 P=0.124 P=0.100 |P=0.016N* P=0.112 P=0.474N P=0.116N | |POLY 1.5 | P=0.211 P=0.222 P=0.124 P=0.103 |P=0.016N* P=0.115 P=0.471N P=0.114N | |POLY 6 | P=0.198 P=0.214 P=0.125 P=0.097 |P=0.016N* P=0.109 P=0.478N P=0.117N | |LOGISTIC REGRESSION| P=0.223 P=0.215 P=0.141 P=0.138 |P=0.016N* P=0.109 P=0.445N (e) | |COCH-ARM / FISHERS | P=0.221 P=0.236 P=0.125 P=0.110 |P=0.015N* P=0.124 P=0.465N P=0.110N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 5 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Blood Vessel: Aorta | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/97 (0%) 0/94 (0%) 1/100 (1%) 1/96 (1%) |2/98 (2%) 0/100 (0%) 0/94 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 1.1% 1.2% |2.2% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/75 (0%) 0/68 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/78 (0%) 0/74 (0%) | |FIRST INCIDENCE | --- --- 636 466 |625 --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.356 (e) P=0.500 P=0.496 |P=0.366N P=0.240N P=0.239N P=0.241N | |POLY 3 | P=0.356 (e) P=0.506 P=0.487 |P=0.365N P=0.236N P=0.244N P=0.239N | |POLY 1.5 | P=0.360 (e) P=0.506 P=0.492 |P=0.365N P=0.235N P=0.245N P=0.239N | |POLY 6 | P=0.351 (e) P=0.507 P=0.482 |P=0.363N P=0.237N P=0.243N P=0.238N | |LOGISTIC REGRESSION| P=0.457 (e) P=0.511 P=0.552 |P=0.358N P=0.229N P=0.248N P=0.228N | |COCH-ARM / FISHERS | P=0.365 (e) P=0.508 P=0.497 |P=0.364N P=0.244N P=0.259N P=0.246N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Bone Marrow | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 33/99 (33%) 30/99 (30%) 28/99 (28%) 30/99 (30%) |23/96 (24%) 13/99 (13%) 13/97 (13%) 14/99 (14%) | |POLY-3 ADJUSTED (b)| 34.9% 33.3% 30.0% 33.4% |25.3% 14.0% 14.2% 15.3% | |TERMINAL (d) | 23/76 (30%) 22/72 (31%) 25/84 (30%) 16/62 (26%) |12/70 (17%) 5/74 (7%) 8/79 (10%) 8/74 (11%) | |FIRST INCIDENCE | 497 612 562 466 |552 64 513 467 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.283 P=0.491N P=0.170N P=0.425 |P=0.267N P=0.053N P=0.039N* P=0.073N | |POLY 3 | P=0.531N P=0.474N P=0.287N P=0.478N |P=0.263N P=0.038N* P=0.044N* P=0.066N | |POLY 1.5 | P=0.505N P=0.436N P=0.280N P=0.437N |P=0.263N P=0.037N* P=0.044N* P=0.064N | |POLY 6 | P=0.523 P=0.512N P=0.291N P=0.523N |P=0.261N P=0.041N* P=0.047N* P=0.068N | |LOGISTIC REGRESSION| P=0.511N P=0.422N P=0.269N P=0.369N |P=0.220N P=0.032N* P=0.045N* P=0.056N | |COCH-ARM / FISHERS | P=0.468N P=0.380N P=0.269N P=0.380N |P=0.244N P=0.039N* P=0.044N* P=0.058N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 6 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Bone Marrow | | Infiltration Cellular Focal Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 1/99 (1%) 2/99 (2%) 0/99 (0%) |0/96 (0%) 0/99 (0%) 1/97 (1%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 3.3% 1.1% 2.2% 0.0% |0.0% 0.0% 1.1% 0.0% | |TERMINAL (d) | 2/76 (3%) 1/72 (1%) 2/84 (2%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 1/79 (1%) 0/74 (0%) | |FIRST INCIDENCE | 715 734 (T) 734 (T) --- |--- --- 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.194N P=0.329N P=0.460N P=0.160N |P=0.766N (e) P=0.524 (e) | |POLY 3 | P=0.170N P=0.322N P=0.500N P=0.135N |P=0.765N (e) P=0.503 (e) | |POLY 1.5 | P=0.165N P=0.316N P=0.500N P=0.129N |P=0.765N (e) P=0.503 (e) | |POLY 6 | P=0.176N P=0.329N P=0.497N P=0.142N |P=0.765N (e) P=0.503 (e) | |LOGISTIC REGRESSION| P=0.180N P=0.331N P=0.492N P=0.145N |(e) (e) P=0.524 (e) | |COCH-ARM / FISHERS | P=0.159N P=0.311N P=0.500N P=0.123N |P=0.764N (e) P=0.503 (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Bone Marrow | | Myelofibrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/99 (1%) 2/99 (2%) 0/99 (0%) |10/96 (10%) 18/99 (18%) 17/97 (18%) 10/99 (10%) | |POLY-3 ADJUSTED (b)| 0.0% 1.1% 2.2% 0.0% |11.3% 20.0% 18.9% 11.1% | |TERMINAL (d) | 0/76 (0%) 1/72 (1%) 1/84 (1%) 0/62 (0%) |10/70 (14%) 17/74 (23%) 17/79 (22%) 8/74 (11%) | |FIRST INCIDENCE | --- 734 (T) 585 --- |735 (T) 705 735 (T) 597 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.486N P=0.489 P=0.252 (e) |P=0.156N P=0.097 P=0.177 P=0.547N | |POLY 3 | P=0.466N P=0.492 P=0.240 (e) |P=0.164N P=0.082 P=0.113 P=0.577N | |POLY 1.5 | P=0.457N P=0.495 P=0.239 (e) |P=0.166N P=0.084 P=0.112 P=0.577N | |POLY 6 | P=0.477N P=0.488 P=0.242 (e) |P=0.158N P=0.080 P=0.111 P=0.573N | |LOGISTIC REGRESSION| P=0.427N P=0.489 P=0.239 (e) |P=0.161N P=0.084 P=0.177 P=0.582N | |COCH-ARM / FISHERS | P=0.444N P=0.500 P=0.249 (e) |P=0.158N P=0.089 P=0.112 P=0.564N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 7 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Bone Marrow: Myeloid Cell | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 3/99 (3%) 0/99 (0%) 5/99 (5%) |3/96 (3%) 0/99 (0%) 0/97 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 2.2% 3.4% 0.0% 5.8% |3.4% 0.0% 0.0% 0.0% | |TERMINAL (d) | 2/76 (3%) 0/72 (0%) 0/84 (0%) 3/62 (5%) |1/70 (1%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 734 (T) 562 --- 671 |666 --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.068 P=0.481 P=0.217N P=0.153 |P=0.238N P=0.118N P=0.113N P=0.118N | |POLY 3 | P=0.093 P=0.487 P=0.238N P=0.193 |P=0.236N P=0.119N P=0.119N P=0.120N | |POLY 1.5 | P=0.098 P=0.492 P=0.239N P=0.204 |P=0.236N P=0.118N P=0.119N P=0.119N | |POLY 6 | P=0.087 P=0.482 P=0.237N P=0.181 |P=0.234N P=0.120N P=0.120N P=0.120N | |LOGISTIC REGRESSION| P=0.115 P=0.545 (e) P=0.178 |P=0.239N P=0.118N P=0.120N P=0.118N | |COCH-ARM / FISHERS | P=0.107 P=0.500 P=0.249N P=0.222 |P=0.237N P=0.117N P=0.121N P=0.117N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Bone: Cartilage, Epiphysis, Femur | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/97 (0%) 0/100 (0%) 2/99 (2%) 0/99 (0%) |0/100 (0%) 0/100 (0%) 0/99 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.2% 0.0% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/75 (0%) 0/72 (0%) 1/84 (1%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/78 (0%) 0/73 (0%) | |FIRST INCIDENCE | --- --- 585 --- |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.667N (e) P=0.253 (e) |(e) (e) (e) (e) | |POLY 3 | P=0.650N (e) P=0.246 (e) |(e) (e) (e) (e) | |POLY 1.5 | P=0.643N (e) P=0.245 (e) |(e) (e) (e) (e) | |POLY 6 | P=0.657N (e) P=0.249 (e) |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.596N (e) P=0.239 (e) |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.633N (e) P=0.254 (e) |(e) (e) (e) (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 8 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Brain: Hypothalamus | | Compression | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/99 (0%) 0/100 (0%) 0/99 (0%) |0/99 (0%) 2/100 (2%) 3/98 (3%) 3/98 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 2.2% 3.3% 3.4% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 2/74 (3%) 3/79 (4%) 2/74 (3%) | |FIRST INCIDENCE | --- --- --- --- |--- 735 (T) 735 (T) 733 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.249 P=0.251 P=0.145 P=0.134 | |POLY 3 | (e) (e) (e) (e) |P=0.236 P=0.240 P=0.122 P=0.118 | |POLY 1.5 | (e) (e) (e) (e) |P=0.235 P=0.240 P=0.121 P=0.118 | |POLY 6 | (e) (e) (e) (e) |P=0.239 P=0.239 P=0.123 P=0.119 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.247 P=0.251 P=0.145 P=0.126 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.239 P=0.251 P=0.121 P=0.121 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Brain: Thalamus | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 70/100 (70%) 68/99 (69%) 60/100 (60%) 78/99 (79%) |47/99 (47%) 68/100 (68%) 55/98 (56%) 60/98 (61%) | |POLY-3 ADJUSTED (b)| 71.8% 70.1% 63.3% 80.3% |50.4% 71.3% 58.7% 63.4% | |TERMINAL (d) | 55/76 (72%) 46/72 (64%) 55/84 (66%) 48/62 (77%) |35/70 (50%) 51/74 (69%) 45/79 (57%) 43/74 (58%) | |FIRST INCIDENCE | 386 400 549 370 |461 387 472 291 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P<0.001 ** P=0.470 P=0.023N* P=0.009 ** |P=0.398 P=0.014 * P=0.395 P=0.113 | |POLY 3 | P=0.031 * P=0.463N P=0.132N P=0.105 |P=0.357 P=0.002 ** P=0.158 P=0.048 * | |POLY 1.5 | P=0.030 * P=0.472N P=0.116N P=0.103 |P=0.320 P=0.002 ** P=0.151 P=0.039 * | |POLY 6 | P=0.033 * P=0.445N P=0.146N P=0.110 |P=0.408 P=0.002 ** P=0.158 P=0.059 | |LOGISTIC REGRESSION| P=0.033 * P=0.445N P=0.086N P=0.134 |P=0.279 P=0.002 ** P=0.153 P=0.034 * | |COCH-ARM / FISHERS | P=0.031 * P=0.481N P=0.091N P=0.104 |P=0.297 P=0.003 ** P=0.142 P=0.036 * | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 9 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Clitoral Gland | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |80/89 (90%) 75/84 (89%) 77/85 (91%) 76/84 (90%) | |POLY-3 ADJUSTED (b)| |92.1% 90.4% 91.6% 91.2% | |TERMINAL (d) | |64/69 (93%) 61/69 (88%) 69/75 (92%) 63/69 (91%) | |FIRST INCIDENCE | |397 387 578 291 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.495N P=0.264N P=0.096N P=0.314N | |POLY 3 | |P=0.562N P=0.448N P=0.568N P=0.524N | |POLY 1.5 | |P=0.570N P=0.507N P=0.589N P=0.560N | |POLY 6 | |P=0.559N P=0.394N P=0.562N P=0.496N | |LOGISTIC REGRESSION| |P=0.520 P=0.586N P=0.514N P=0.572 | |COCH-ARM / FISHERS | |P=0.493 P=0.547N P=0.540 P=0.551 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Clitoral Gland | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |84/89 (94%) 82/84 (98%) 81/85 (95%) 76/84 (90%) | |POLY-3 ADJUSTED (b)| |96.0% 98.8% 96.4% 92.9% | |TERMINAL (d) | |67/69 (97%) 68/69 (99%) 73/75 (97%) 65/69 (94%) | |FIRST INCIDENCE | |397 387 578 477 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.119N P=0.425N P=0.069N P=0.111N | |POLY 3 | |P=0.066N P=0.242 P=0.607 P=0.286N | |POLY 1.5 | |P=0.050N P=0.198 P=0.597 P=0.262N | |POLY 6 | |P=0.092N P=0.298 P=0.608 P=0.321N | |LOGISTIC REGRESSION| |P=0.031N* P=0.168 P=0.555N P=0.196N | |COCH-ARM / FISHERS | |P=0.054N P=0.246 P=0.529 P=0.247N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 10 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Epididymis | | Granuloma Sperm | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 3/99 (3%) 2/99 (2%) 2/96 (2%) | | |POLY-3 ADJUSTED (b)| 2.2% 3.4% 2.2% 2.4% | | |TERMINAL (d) | 1/76 (1%) 3/72 (4%) 2/84 (2%) 1/62 (2%) | | |FIRST INCIDENCE | 684 734 (T) 734 (T) 480 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.617N P=0.472 P=0.664N P=0.640 | | |POLY 3 | P=0.570N P=0.484 P=0.688N P=0.663 | | |POLY 1.5 | P=0.560N P=0.492 P=0.688N P=0.672 | | |POLY 6 | P=0.581N P=0.474 P=0.686N P=0.651 | | |LOGISTIC REGRESSION| P=0.540N P=0.479 P=0.688N P=0.643N | | |COCH-ARM / FISHERS | P=0.547N P=0.505 P=0.686N P=0.682 | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Epididymis | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 24/98 (24%) 11/99 (11%) 21/99 (21%) 18/96 (19%) | | |POLY-3 ADJUSTED (b)| 26.1% 12.5% 22.5% 21.4% | | |TERMINAL (d) | 21/76 (28%) 11/72 (15%) 19/84 (23%) 14/62 (23%) | | |FIRST INCIDENCE | 624 734 (T) 585 609 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.275 P=0.019N* P=0.250N P=0.432N | | |POLY 3 | P=0.447 P=0.016N* P=0.341N P=0.288N | | |POLY 1.5 | P=0.471 P=0.013N* P=0.346N P=0.256N | | |POLY 6 | P=0.420 P=0.019N* P=0.332N P=0.326N | | |LOGISTIC REGRESSION| P=0.398 P=0.019N* P=0.343N P=0.321N | | |COCH-ARM / FISHERS | P=0.510 P=0.011N* P=0.353N P=0.213N | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 11 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Epididymis | | Spermatocele | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 0/99 (0%) 3/99 (3%) 7/96 (7%) | | |POLY-3 ADJUSTED (b)| 2.2% 0.0% 3.2% 8.3% | | |TERMINAL (d) | 2/76 (3%) 0/72 (0%) 3/84 (4%) 4/62 (7%) | | |FIRST INCIDENCE | 734 (T) --- 734 (T) 500 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.002 ** P=0.251N P=0.545 P=0.054 | | |POLY 3 | P=0.004 ** P=0.246N P=0.507 P=0.068 | | |POLY 1.5 | P=0.004 ** P=0.242N P=0.506 P=0.073 | | |POLY 6 | P=0.003 ** P=0.250N P=0.510 P=0.063 | | |LOGISTIC REGRESSION| P=0.004 ** (e) P=0.545 P=0.088 | | |COCH-ARM / FISHERS | P=0.004 ** P=0.246N P=0.505 P=0.080 | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Eye: Cornea | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/0 (0%) 1/2 (50%) 0/0 (0%) 0/2 (0%) |2/2 (100%) 0/2 (0%) 1/1 (100%) 0/1 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 77.6% 0.0% 0.0% |100.0% 0.0% 100.0% 0.0% | |TERMINAL (d) | 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/1 (0%) |2/2 (100%) 0/1 (0%) 1/1 (100%) 0/1 (0%) | |FIRST INCIDENCE | --- 734 (T) --- --- |735 (T) --- 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.421N P=1.000N (e) (e) |P=0.399N P=0.362N (e) P=0.362N | |POLY 3 | P=1.000 P=1.000N (e) (e) |P=0.215N P=0.317N (e) P=1.000 | |POLY 1.5 | P=1.000 P=1.000N (e) (e) |P=0.214N P=0.299N (e) P=1.000 | |POLY 6 | P=1.000 P=1.000N (e) (e) |P=0.215N P=0.318N (e) P=1.000 | |LOGISTIC REGRESSION| (e) P=1.000N (e) (e) |P=0.399N (e) (e) (e) | |COCH-ARM / FISHERS | P=0.409N P=1.000 (e) (e) |P=0.498N P=0.167N (e) P=0.333N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 12 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Gallbladder: Epithelium | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/84 (0%) 4/83 (5%) 2/84 (2%) 2/75 (3%) |5/70 (7%) 14/84 (17%) 2/87 (2%) 3/79 (4%) | |POLY-3 ADJUSTED (b)| 0.0% 5.2% 2.5% 2.8% |7.5% 17.5% 2.4% 4.0% | |TERMINAL (d) | 0/69 (0%) 4/68 (6%) 2/77 (3%) 2/60 (3%) |4/62 (7%) 10/72 (14%) 2/79 (3%) 3/70 (4%) | |FIRST INCIDENCE | --- 734 (T) 734 (T) 734 (T) |725 461 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.571 P=0.063 P=0.263 P=0.209 |P=0.039N* P=0.050 P=0.144N P=0.301N | |POLY 3 | P=0.587 P=0.061 P=0.242 P=0.213 |P=0.037N* P=0.057 P=0.140N P=0.300N | |POLY 1.5 | P=0.588 P=0.061 P=0.240 P=0.214 |P=0.037N* P=0.057 P=0.140N P=0.300N | |POLY 6 | P=0.585 P=0.061 P=0.245 P=0.213 |P=0.036N* P=0.058 P=0.141N P=0.301N | |LOGISTIC REGRESSION| (e) P=0.063 P=0.263 P=0.209 |P=0.038N* P=0.060 P=0.143N P=0.300N | |COCH-ARM / FISHERS | P=0.588 P=0.059 P=0.249 P=0.221 |P=0.038N* P=0.060 P=0.142N P=0.294N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Harderian Gland | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/99 (11%) 13/99 (13%) 16/100 (16%) 9/96 (9%) |27/98 (28%) 23/97 (24%) 36/99 (36%) 32/96 (33%) | |POLY-3 ADJUSTED (b)| 12.0% 14.7% 17.1% 10.7% |30.2% 25.8% 38.9% 36.1% | |TERMINAL (d) | 11/76 (15%) 13/72 (18%) 15/84 (18%) 6/62 (10%) |25/70 (36%) 21/74 (28%) 31/79 (39%) 25/74 (34%) | |FIRST INCIDENCE | 734 (T) 734 (T) 562 510 |551 545 578 566 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.406N P=0.357 P=0.286 P=0.584N |P=0.202 P=0.237N P=0.239 P=0.349 | |POLY 3 | P=0.286N P=0.371 P=0.217 P=0.485N |P=0.157 P=0.316N P=0.137 P=0.245 | |POLY 1.5 | P=0.271N P=0.388 P=0.214 P=0.465N |P=0.149 P=0.322N P=0.130 P=0.233 | |POLY 6 | P=0.305N P=0.352 P=0.223 P=0.507N |P=0.173 P=0.308N P=0.142 P=0.266 | |LOGISTIC REGRESSION| P=0.310N P=0.357 P=0.217 P=0.494N |P=0.158 P=0.319N P=0.129 P=0.244 | |COCH-ARM / FISHERS | P=0.248N P=0.414 P=0.212 P=0.436N |P=0.156 P=0.327N P=0.120 P=0.236 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 13 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Heart | | Inflammation Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 1/100 (1%) 5/100 (5%) 2/99 (2%) |0/98 (0%) 0/100 (0%) 0/100 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 2.1% 1.1% 5.4% 2.3% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 1/76 (1%) 1/72 (1%) 4/84 (5%) 2/62 (3%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 386 734 (T) 636 734 (T) |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.543 P=0.512N P=0.252 P=0.636 |(e) (e) (e) (e) | |POLY 3 | P=0.586 P=0.518N P=0.221 P=0.661 |(e) (e) (e) (e) | |POLY 1.5 | P=0.599 P=0.511N P=0.220 P=0.672 |(e) (e) (e) (e) | |POLY 6 | P=0.571 P=0.525N P=0.225 P=0.648 |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.605N P=0.432N P=0.216 P=0.629N |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.618 P=0.500N P=0.222 P=0.686 |(e) (e) (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Heart: Myocardium | | Degeneration | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) 2/100 (2%) 0/99 (0%) |1/98 (1%) 4/100 (4%) 0/100 (0%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.1% 0.0% |1.1% 4.4% 0.0% 1.1% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 1/84 (1%) 0/62 (0%) |1/70 (1%) 2/74 (3%) 0/79 (0%) 1/74 (1%) | |FIRST INCIDENCE | --- --- 636 --- |735 (T) 387 --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.668N (e) P=0.251 (e) |P=0.344N P=0.197 P=0.476N P=0.749N | |POLY 3 | P=0.651N (e) P=0.241 (e) |P=0.348N P=0.190 P=0.495N P=0.759N | |POLY 1.5 | P=0.645N (e) P=0.240 (e) |P=0.348N P=0.189 P=0.496N P=0.760N | |POLY 6 | P=0.659N (e) P=0.243 (e) |P=0.346N P=0.190 P=0.495N P=0.758N | |LOGISTIC REGRESSION| P=0.623N (e) P=0.237 (e) |P=0.342N P=0.194 (e) P=0.749N | |COCH-ARM / FISHERS | P=0.637N (e) P=0.249 (e) |P=0.347N P=0.191 P=0.495N P=0.749N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 14 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Heart: Myocardium | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/99 (0%) |1/98 (1%) 3/100 (3%) 1/100 (1%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |1.1% 3.3% 1.1% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 1/74 (1%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 721 692 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.162N P=0.324 P=0.750N P=0.489N | |POLY 3 | (e) (e) (e) (e) |P=0.165N P=0.313 P=0.755N P=0.499N | |POLY 1.5 | (e) (e) (e) (e) |P=0.165N P=0.313 P=0.756N P=0.500N | |POLY 6 | (e) (e) (e) (e) |P=0.164N P=0.312 P=0.755N P=0.498N | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.164N P=0.312 P=0.757N (e) | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.164N P=0.318 P=0.746N P=0.497N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Intestine Large, Cecum: Lymphoid Tissue | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 41/90 (46%) 33/89 (37%) 37/92 (40%) 20/81 (25%) |25/78 (32%) 33/87 (38%) 35/90 (39%) 24/87 (28%) | |POLY-3 ADJUSTED (b)| 47.4% 39.1% 42.2% 26.6% |32.7% 40.1% 40.1% 28.3% | |TERMINAL (d) | 37/76 (49%) 29/72 (40%) 37/84 (44%) 15/62 (24%) |22/69 (32%) 31/74 (42%) 32/79 (41%) 18/74 (24%) | |FIRST INCIDENCE | 624 612 734 (T) 666 |397 64 21 85 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.018N* P=0.230N P=0.153N P=0.014N* |P=0.138N P=0.204 P=0.203 P=0.410N | |POLY 3 | P=0.007N** P=0.169N P=0.293N P=0.004N** |P=0.092N P=0.209 P=0.204 P=0.332N | |POLY 1.5 | P=0.006N** P=0.162N P=0.288N P=0.004N** |P=0.097N P=0.228 P=0.212 P=0.329N | |POLY 6 | P=0.008N** P=0.181N P=0.298N P=0.005N** |P=0.087N P=0.193 P=0.193 P=0.334N | |LOGISTIC REGRESSION| P=0.009N** P=0.187N P=0.268N P=0.006N** |P=0.105N P=0.275 P=0.241 P=0.281N | |COCH-ARM / FISHERS | P=0.006N** P=0.159N P=0.282N P=0.003N** |P=0.106N P=0.266 P=0.224 P=0.324N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 15 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Intestine Small, Ileum: Muscularis | | Hypertrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/91 (0%) 9/89 (10%) 8/92 (9%) 0/81 (0%) |17/78 (22%) 16/85 (19%) 20/90 (22%) 17/87 (20%) | |POLY-3 ADJUSTED (b)| 0.0% 10.6% 9.0% 0.0% |22.8% 19.9% 23.0% 20.7% | |TERMINAL (d) | 0/76 (0%) 5/72 (7%) 6/84 (7%) 0/62 (0%) |16/69 (23%) 15/74 (20%) 18/79 (23%) 16/74 (22%) | |FIRST INCIDENCE | --- 589 562 --- |608 726 21 690 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.049N* P=0.003 ** P=0.008 ** (e) |P=0.523N P=0.414N P=0.523 P=0.492N | |POLY 3 | P=0.044N* P=0.002 ** P=0.006 ** (e) |P=0.482N P=0.407N P=0.561 P=0.449N | |POLY 1.5 | P=0.042N* P=0.002 ** P=0.005 ** (e) |P=0.478N P=0.404N P=0.561 P=0.444N | |POLY 6 | P=0.047N* P=0.002 ** P=0.006 ** (e) |P=0.490N P=0.412N P=0.550 P=0.459N | |LOGISTIC REGRESSION| P=0.037N* P=0.003 ** P=0.006 ** (e) |P=0.472N P=0.400N P=0.555 P=0.447N | |COCH-ARM / FISHERS | P=0.042N* P<0.001 ** P=0.003 ** (e) |P=0.471N P=0.391N P=0.549 P=0.434N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Intestine Small, Ileum: Peyer's Patch | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/91 (0%) 1/89 (1%) 0/92 (0%) 1/81 (1%) |4/78 (5%) 2/85 (2%) 4/90 (4%) 4/87 (5%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% 0.0% 1.3% |5.3% 2.5% 4.7% 4.9% | |TERMINAL (d) | 0/76 (0%) 1/72 (1%) 0/84 (0%) 1/62 (2%) |3/69 (4%) 2/74 (3%) 3/79 (4%) 4/74 (5%) | |FIRST INCIDENCE | --- 734 (T) --- 734 (T) |334 735 (T) 578 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.453 P=0.489 (e) P=0.459 |P=0.457 P=0.314N P=0.584N P=0.609N | |POLY 3 | P=0.467 P=0.493 (e) P=0.471 |P=0.476 P=0.309N P=0.568N P=0.592N | |POLY 1.5 | P=0.469 P=0.494 (e) P=0.473 |P=0.478 P=0.308N P=0.567N P=0.589N | |POLY 6 | P=0.463 P=0.491 (e) P=0.468 |P=0.472 P=0.310N P=0.571N P=0.596N | |LOGISTIC REGRESSION| (e) P=0.489 (e) P=0.459 |P=0.482 P=0.275N P=0.538N P=0.567N | |COCH-ARM / FISHERS | P=0.473 P=0.494 (e) P=0.471 |P=0.481 P=0.301N P=0.558N P=0.578N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 16 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Intestine Small, Jejunum: Muscularis | | Hypertrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/89 (0%) 3/94 (3%) 1/93 (1%) 0/80 (0%) |6/79 (8%) 8/86 (9%) 5/89 (6%) 3/91 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 3.5% 1.1% 0.0% |7.9% 9.9% 5.9% 3.5% | |TERMINAL (d) | 0/76 (0%) 3/72 (4%) 0/84 (0%) 0/62 (0%) |6/69 (9%) 8/74 (11%) 5/79 (6%) 1/74 (1%) | |FIRST INCIDENCE | --- 734 (T) 636 --- |735 (T) 735 (T) 735 (T) 183 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.266N P=0.113 P=0.498 (e) |P=0.113N P=0.443 P=0.408N P=0.224N | |POLY 3 | P=0.276N P=0.121 P=0.508 (e) |P=0.091N P=0.436 P=0.425N P=0.188N | |POLY 1.5 | P=0.270N P=0.125 P=0.508 (e) |P=0.091N P=0.440 P=0.425N P=0.187N | |POLY 6 | P=0.283N P=0.116 P=0.508 (e) |P=0.092N P=0.435 P=0.427N P=0.189N | |LOGISTIC REGRESSION| P=0.261N P=0.113 P=0.516 (e) |P=0.089N P=0.443 P=0.408N P=0.137N | |COCH-ARM / FISHERS | P=0.262N P=0.133 P=0.511 (e) |P=0.091N P=0.456 P=0.417N P=0.183N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Intestine Small, Jejunum: Peyer's Patch | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/89 (1%) 5/94 (5%) 1/93 (1%) 0/80 (0%) |3/79 (4%) 6/86 (7%) 5/89 (6%) 0/91 (0%) | |POLY-3 ADJUSTED (b)| 1.2% 5.9% 1.1% 0.0% |4.0% 7.4% 5.9% 0.0% | |TERMINAL (d) | 1/76 (1%) 5/72 (7%) 1/84 (1%) 0/62 (0%) |3/69 (4%) 6/74 (8%) 5/79 (6%) 0/74 (0%) | |FIRST INCIDENCE | 734 (T) 734 (T) 734 (T) --- |735 (T) 735 (T) 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.105N P=0.094 P=0.739N P=0.541N |P=0.029N* P=0.281 P=0.434 P=0.110N | |POLY 3 | P=0.108N P=0.105 P=0.752N P=0.530N |P=0.026N* P=0.277 P=0.420 P=0.101N | |POLY 1.5 | P=0.104N P=0.110 P=0.752N P=0.527N |P=0.026N* P=0.280 P=0.420 P=0.101N | |POLY 6 | P=0.112N P=0.099 P=0.752N P=0.534N |P=0.026N* P=0.276 P=0.418 P=0.102N | |LOGISTIC REGRESSION| P=0.105N P=0.094 P=0.739N (e) |P=0.029N* P=0.281 P=0.434 (e) | |COCH-ARM / FISHERS | P=0.100N P=0.119 P=0.740N P=0.527N |P=0.025N* P=0.292 P=0.428 P=0.098N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 17 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Islets, Pancreatic | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 97/99 (98%) 88/99 (89%) 84/98 (86%) 84/97 (87%) |40/87 (46%) 60/95 (63%) 42/94 (45%) 48/94 (51%) | |POLY-3 ADJUSTED (b)| 98.2% 89.3% 87.6% 88.7% |47.7% 65.6% 46.0% 52.7% | |TERMINAL (d) | 75/76 (99%) 64/72 (89%) 73/84 (87%) 57/62 (92%) |35/70 (50%) 50/74 (68%) 33/79 (42%) 37/74 (50%) | |FIRST INCIDENCE | 386 400 527 448 |334 387 472 474 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.147 P=0.341N P=0.002N** P=0.388 |P=0.452N P=0.009 ** P=0.437N P=0.247 | |POLY 3 | P=0.133N P=0.010N* P=0.003N** P=0.005N** |P=0.372N P=0.011 * P=0.467N P=0.307 | |POLY 1.5 | P=0.103N P=0.010N* P=0.002N** P=0.004N** |P=0.384N P=0.011 * P=0.483N P=0.295 | |POLY 6 | P=0.185N P=0.009N** P=0.004N** P=0.008N** |P=0.358N P=0.011 * P=0.453N P=0.320 | |LOGISTIC REGRESSION| P=0.091N P=0.009N** P=0.002N** P=0.004N** |P=0.391N P=0.013 * P=0.490N P=0.292 | |COCH-ARM / FISHERS | P=0.075N P=0.009N** P<0.001N** P=0.002N** |P=0.391N P=0.015 * P=0.490N P=0.296 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Islets, Pancreatic | | Infiltration Cellular Focal Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/99 (0%) 0/98 (0%) 0/97 (0%) |0/87 (0%) 2/95 (2%) 1/94 (1%) 3/94 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 2.3% 1.1% 3.4% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 2/74 (3%) 1/79 (1%) 3/74 (4%) | |FIRST INCIDENCE | --- --- --- --- |--- 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.161 P=0.251 P=0.524 P=0.132 | |POLY 3 | (e) (e) (e) (e) |P=0.165 P=0.251 P=0.514 P=0.133 | |POLY 1.5 | (e) (e) (e) (e) |P=0.165 P=0.253 P=0.514 P=0.134 | |POLY 6 | (e) (e) (e) (e) |P=0.165 P=0.249 P=0.512 P=0.132 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) P=0.251 P=0.524 P=0.132 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.167 P=0.271 P=0.519 P=0.138 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 18 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney | | Hydronephrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 1/98 (1%) 3/99 (3%) 0/96 (0%) |0/92 (0%) 1/96 (1%) 0/98 (0%) 1/98 (1%) | |POLY-3 ADJUSTED (b)| 1.1% 1.1% 3.2% 0.0% |0.0% 1.1% 0.0% 1.1% | |TERMINAL (d) | 1/76 (1%) 0/72 (0%) 1/84 (1%) 0/62 (0%) |0/70 (0%) 1/74 (1%) 0/79 (0%) 1/74 (1%) | |FIRST INCIDENCE | 734 (T) 719 585 --- |--- 735 (T) --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.331N P=0.753 P=0.327 P=0.541N |P=0.503 P=0.511 (e) P=0.511 | |POLY 3 | P=0.316N P=0.750 P=0.312 P=0.518N |P=0.500 P=0.503 (e) P=0.506 | |POLY 1.5 | P=0.309N P=0.753 P=0.310 P=0.513N |P=0.501 P=0.505 (e) P=0.507 | |POLY 6 | P=0.325N P=0.747 P=0.317 P=0.523N |P=0.499 P=0.503 (e) P=0.505 | |LOGISTIC REGRESSION| P=0.282N P=0.747 P=0.305 (e) |(e) P=0.511 (e) P=0.511 | |COCH-ARM / FISHERS | P=0.300N P=0.749 P=0.311 P=0.508N |P=0.508 P=0.511 (e) P=0.516 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney | | Infarct Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 3/98 (3%) 2/99 (2%) 0/96 (0%) |0/92 (0%) 0/96 (0%) 0/98 (0%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 1.1% 3.4% 2.2% 0.0% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/76 (0%) 3/72 (4%) 1/84 (1%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 717 734 (T) 562 --- |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.192N P=0.290 P=0.520 P=0.530N |(e) (e) (e) (e) | |POLY 3 | P=0.179N P=0.290 P=0.504 P=0.518N |(e) (e) (e) (e) | |POLY 1.5 | P=0.173N P=0.295 P=0.502 P=0.513N |(e) (e) (e) (e) | |POLY 6 | P=0.187N P=0.284 P=0.507 P=0.524N |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.163N P=0.282 P=0.499 P=0.517N |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.165N P=0.307 P=0.500 P=0.508N |(e) (e) (e) (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 19 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Cortex | | Congestion | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/98 (0%) 2/99 (2%) 0/96 (0%) |0/92 (0%) 0/96 (0%) 0/98 (0%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 2.2% 0.0% 2.2% 0.0% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 2/76 (3%) 0/72 (0%) 2/84 (2%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 734 (T) --- 734 (T) --- |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.361N P=0.251N P=0.657N P=0.285N |(e) (e) (e) (e) | |POLY 3 | P=0.328N P=0.249N P=0.691N P=0.259N |(e) (e) (e) (e) | |POLY 1.5 | P=0.324N P=0.246N P=0.692N P=0.253N |(e) (e) (e) (e) | |POLY 6 | P=0.333N P=0.253N P=0.688N P=0.265N |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.361N (e) P=0.657N (e) |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.319N P=0.251N P=0.689N P=0.256N |(e) (e) (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Cortex | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 23/99 (23%) 30/98 (31%) 27/99 (27%) 17/96 (18%) |0/92 (0%) 1/96 (1%) 0/98 (0%) 3/98 (3%) | |POLY-3 ADJUSTED (b)| 24.7% 34.0% 29.1% 20.2% |0.0% 1.1% 0.0% 3.4% | |TERMINAL (d) | 19/76 (25%) 26/72 (36%) 24/84 (29%) 16/62 (26%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 3/74 (4%) | |FIRST INCIDENCE | 579 612 636 708 |--- 705 --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.158N P=0.117 P=0.451 P=0.421N |P=0.044 * P=0.502 (e) P=0.132 | |POLY 3 | P=0.074N P=0.113 P=0.307 P=0.294N |P=0.045 * P=0.504 (e) P=0.126 | |POLY 1.5 | P=0.061N P=0.129 P=0.308 P=0.261N |P=0.045 * P=0.505 (e) P=0.128 | |POLY 6 | P=0.093N P=0.096 P=0.312 P=0.338N |P=0.045 * P=0.503 (e) P=0.126 | |LOGISTIC REGRESSION| P=0.082N P=0.106 P=0.322 P=0.321N |P=0.045 * P=0.509 (e) P=0.132 | |COCH-ARM / FISHERS | P=0.047N* P=0.157 P=0.312 P=0.219N |P=0.047 * P=0.511 (e) P=0.135 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 20 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Cortex | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 19/99 (19%) 18/98 (18%) 20/99 (20%) 16/96 (17%) |24/92 (26%) 17/96 (18%) 21/98 (21%) 15/98 (15%) | |POLY-3 ADJUSTED (b)| 20.4% 20.4% 21.5% 18.9% |27.5% 19.4% 23.1% 16.9% | |TERMINAL (d) | 16/76 (21%) 15/72 (21%) 19/84 (23%) 14/62 (23%) |20/70 (29%) 14/74 (19%) 20/79 (25%) 14/74 (19%) | |FIRST INCIDENCE | 579 653 590 518 |542 705 659 699 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.513 P=0.571 P=0.519N P=0.550 |P=0.128N P=0.114N P=0.230N P=0.056N | |POLY 3 | P=0.422N P=0.571 P=0.497 P=0.473N |P=0.127N P=0.137N P=0.307N P=0.064N | |POLY 1.5 | P=0.394N P=0.550N P=0.497 P=0.440N |P=0.124N P=0.129N P=0.297N P=0.060N | |POLY 6 | P=0.458N P=0.545 P=0.502 P=0.515N |P=0.128N P=0.145N P=0.326N P=0.068N | |LOGISTIC REGRESSION| P=0.438N P=0.572N P=0.506 P=0.466N |P=0.125N P=0.130N P=0.298N P=0.061N | |COCH-ARM / FISHERS | P=0.356N P=0.514N P=0.500 P=0.393N |P=0.110N P=0.112N P=0.280N P=0.048N* | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Cortex | | Metaplasia Focal Osseous | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/99 (4%) 4/98 (4%) 8/99 (8%) 2/96 (2%) |4/92 (4%) 3/96 (3%) 3/98 (3%) 3/98 (3%) | |POLY-3 ADJUSTED (b)| 4.3% 4.5% 8.6% 2.4% |4.6% 3.4% 3.3% 3.4% | |TERMINAL (d) | 3/76 (4%) 3/72 (4%) 5/84 (6%) 1/62 (2%) |1/70 (1%) 2/74 (3%) 3/79 (4%) 2/74 (3%) | |FIRST INCIDENCE | 666 660 640 545 |397 698 735 (T) 654 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.284N P=0.603 P=0.223 P=0.418N |P=0.522N P=0.485N P=0.456N P=0.484N | |POLY 3 | P=0.242N P=0.615 P=0.190 P=0.379N |P=0.518N P=0.498N P=0.481N P=0.491N | |POLY 1.5 | P=0.232N P=0.623 P=0.188 P=0.369N |P=0.516N P=0.492N P=0.476N P=0.485N | |POLY 6 | P=0.254N P=0.607 P=0.196 P=0.392N |P=0.518N P=0.502N P=0.488N P=0.494N | |LOGISTIC REGRESSION| P=0.217N P=0.621 P=0.186 P=0.332N |P=0.493N P=0.434N P=0.439N P=0.409N | |COCH-ARM / FISHERS | P=0.218N P=0.634 P=0.186 P=0.356N |P=0.505N P=0.476N P=0.465N P=0.465N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 21 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Cortex | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 79/99 (80%) 78/98 (80%) 78/99 (79%) 66/96 (69%) |1/92 (1%) 1/96 (1%) 0/98 (0%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 83.6% 85.0% 81.4% 72.5% |1.2% 1.1% 0.0% 0.0% | |TERMINAL (d) | 66/76 (87%) 66/72 (92%) 69/84 (82%) 43/62 (69%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 579 542 549 466 |625 496 --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.534 P=0.355 P=0.142N P=0.536 |P=0.369N P=0.759N P=0.496N P=0.502N | |POLY 3 | P=0.010N* P=0.479 P=0.412N P=0.042N* |P=0.362N P=0.756N P=0.491N P=0.495N | |POLY 1.5 | P=0.014N* P=0.523 P=0.451N P=0.046N* |P=0.361N P=0.755N P=0.490N P=0.493N | |POLY 6 | P=0.008N** P=0.430 P=0.356N P=0.037N* |P=0.362N P=0.757N P=0.493N P=0.497N | |LOGISTIC REGRESSION| P=0.057N P=0.322 P=0.503N P=0.121N |P=0.319N P=0.690N P=0.460N P=0.448N | |COCH-ARM / FISHERS | P=0.022N* P=0.556N P=0.500N P=0.054N |P=0.359N P=0.741N P=0.484N P=0.484N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Cortex, Renal Tubule | | Degeneration | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 72/99 (73%) 75/98 (77%) 76/99 (77%) 57/96 (59%) |4/99 (4%) 2/98 (2%) 2/99 (2%) 1/96 (1%) | |POLY-3 ADJUSTED (b)| 77.0% 82.9% 81.0% 65.3% |4.4% 2.3% 2.2% 1.2% | |TERMINAL (d) | 62/76 (82%) 64/72 (89%) 72/84 (86%) 42/62 (68%) |4/76 (5%) 2/72 (3%) 2/84 (2%) 1/62 (2%) | |FIRST INCIDENCE | 603 400 556 525 |734 (T) 734 (T) 734 (T) 734 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.205N P=0.171 P=0.373N P=0.403N |P=0.297N P=0.364N P=0.295N P=0.248N | |POLY 3 | P=0.003N** P=0.192 P=0.299 P=0.050N |P=0.254N P=0.361N P=0.337N P=0.210N | |POLY 1.5 | P=0.003N** P=0.248 P=0.301 P=0.042N* |P=0.248N P=0.354N P=0.339N P=0.203N | |POLY 6 | P=0.003N** P=0.135 P=0.306 P=0.060N |P=0.261N P=0.369N P=0.333N P=0.219N | |LOGISTIC REGRESSION| P=0.011N* P=0.100 P=0.303 P=0.120N |P=0.297N P=0.364N P=0.295N P=0.248N | |COCH-ARM / FISHERS | P=0.003N** P=0.327 P=0.312 P=0.034N* |P=0.239N P=0.346N P=0.341N P=0.194N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 22 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Cortex, Renal Tubule | | Dilatation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 1/98 (1%) 1/99 (1%) 5/96 (5%) |1/92 (1%) 1/96 (1%) 1/98 (1%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 2.2% 1.1% 1.1% 5.8% |1.2% 1.1% 1.1% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 1/62 (2%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 520 560 527 518 |608 547 578 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.031 * P=0.516N P=0.501N P=0.181 |P=0.341N P=0.758 P=0.757N P=0.504N | |POLY 3 | P=0.036 * P=0.518N P=0.499N P=0.190 |P=0.335N P=0.756N P=0.749N P=0.495N | |POLY 1.5 | P=0.037 * P=0.512N P=0.500N P=0.197 |P=0.334N P=0.755N P=0.748N P=0.494N | |POLY 6 | P=0.034 * P=0.524N P=0.498N P=0.181 |P=0.336N P=0.757N P=0.751N P=0.497N | |LOGISTIC REGRESSION| P=0.078 P=0.409N P=0.501N P=0.331 |P=0.286N P=0.698N P=0.711N P=0.438N | |COCH-ARM / FISHERS | P=0.039 * P=0.504N P=0.500N P=0.210 |P=0.328N P=0.741N P=0.735N P=0.484N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Medulla | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 54/99 (55%) 40/98 (41%) 56/99 (57%) 41/96 (43%) |47/92 (51%) 53/96 (55%) 56/98 (57%) 58/98 (59%) | |POLY-3 ADJUSTED (b)| 57.2% 45.1% 60.0% 47.9% |52.8% 57.9% 60.8% 63.5% | |TERMINAL (d) | 44/76 (58%) 37/72 (51%) 53/84 (63%) 34/62 (55%) |41/70 (59%) 43/74 (58%) 51/79 (65%) 48/74 (65%) | |FIRST INCIDENCE | 520 589 590 604 |334 387 578 497 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.475 P=0.071N P=0.390N P=0.339N |P=0.156 P=0.355 P=0.357 P=0.142 | |POLY 3 | P=0.259N P=0.064N P=0.404 P=0.132N |P=0.133 P=0.293 P=0.171 P=0.094 | |POLY 1.5 | P=0.219N P=0.050N P=0.418 P=0.099N |P=0.143 P=0.297 P=0.190 P=0.102 | |POLY 6 | P=0.312N P=0.085N P=0.393 P=0.181N |P=0.138 P=0.297 P=0.151 P=0.096 | |LOGISTIC REGRESSION| P=0.313N P=0.064N P=0.456 P=0.147N |P=0.165 P=0.325 P=0.225 P=0.124 | |COCH-ARM / FISHERS | P=0.172N P=0.037N* P=0.443 P=0.065N |P=0.209 P=0.337 P=0.245 P=0.165 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 23 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Medulla | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 0/98 (0%) 0/99 (0%) 0/96 (0%) |3/92 (3%) 1/96 (1%) 0/98 (0%) 2/98 (2%) | |POLY-3 ADJUSTED (b)| 1.1% 0.0% 0.0% 0.0% |3.5% 1.1% 0.0% 2.3% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 1/74 (1%) 0/79 (0%) 2/74 (3%) | |FIRST INCIDENCE | 666 --- --- --- |625 735 (T) --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.606N P=0.524N P=0.505N P=0.521N |P=0.583 P=0.298N P=0.116N P=0.484N | |POLY 3 | P=0.599N P=0.510N P=0.500N P=0.518N |P=0.589 P=0.303N P=0.113N P=0.490N | |POLY 1.5 | P=0.600N P=0.507N P=0.500N P=0.513N |P=0.589 P=0.300N P=0.112N P=0.486N | |POLY 6 | P=0.599N P=0.514N P=0.498N P=0.524N |P=0.590 P=0.306N P=0.115N P=0.493N | |LOGISTIC REGRESSION| P=0.583N P=0.483N P=0.501N P=0.481N |P=0.591 P=0.286N P=0.106N P=0.473N | |COCH-ARM / FISHERS | P=0.601N P=0.503N P=0.500N P=0.508N |P=0.594 P=0.295N P=0.112N P=0.470N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Pelvis | | Calculus Micro Observation Only | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/98 (0%) 0/99 (0%) 0/96 (0%) |3/92 (3%) 2/96 (2%) 2/98 (2%) 1/98 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |3.5% 2.3% 2.2% 1.1% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |3/70 (4%) 2/74 (3%) 2/79 (3%) 1/74 (1%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.295N P=0.475N P=0.445N P=0.287N | |POLY 3 | (e) (e) (e) (e) |P=0.295N P=0.492N P=0.477N P=0.297N | |POLY 1.5 | (e) (e) (e) (e) |P=0.294N P=0.489N P=0.475N P=0.295N | |POLY 6 | (e) (e) (e) (e) |P=0.295N P=0.494N P=0.481N P=0.298N | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.295N P=0.475N P=0.445N P=0.287N | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.287N P=0.480N P=0.470N P=0.287N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 24 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/98 (0%) |1/98 (1%) 0/97 (0%) 0/98 (0%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |1.1% 0.0% 0.0% 2.2% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 0/74 (0%) 0/79 (0%) 2/74 (3%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) --- --- 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.164 P=0.489N P=0.476N P=0.519 | |POLY 3 | (e) (e) (e) (e) |P=0.164 P=0.502N P=0.498N P=0.500 | |POLY 1.5 | (e) (e) (e) (e) |P=0.164 P=0.502N P=0.499N P=0.500 | |POLY 6 | (e) (e) (e) (e) |P=0.164 P=0.502N P=0.499N P=0.501 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.164 (e) (e) P=0.519 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.166 P=0.503N P=0.500N P=0.504 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Basophilic Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) 0/100 (0%) 0/98 (0%) |2/98 (2%) 3/97 (3%) 5/98 (5%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 2.3% 0.0% 0.0% |2.2% 3.4% 5.5% 2.2% | |TERMINAL (d) | 0/76 (0%) 2/72 (3%) 0/84 (0%) 0/62 (0%) |2/70 (3%) 3/74 (4%) 5/79 (6%) 2/74 (3%) | |FIRST INCIDENCE | --- 734 (T) --- --- |735 (T) 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.404N P=0.227 (e) (e) |P=0.435N P=0.525 P=0.271 P=0.673N | |POLY 3 | P=0.387N P=0.229 (e) (e) |P=0.442N P=0.495 P=0.224 P=0.692 | |POLY 1.5 | P=0.381N P=0.233 (e) (e) |P=0.442N P=0.495 P=0.223 P=0.692 | |POLY 6 | P=0.395N P=0.225 (e) (e) |P=0.441N P=0.496 P=0.223 P=0.692N | |LOGISTIC REGRESSION| (e) P=0.227 (e) (e) |P=0.435N P=0.525 P=0.271 P=0.673N | |COCH-ARM / FISHERS | P=0.371N P=0.249 (e) (e) |P=0.435N P=0.495 P=0.222 P=0.686N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 25 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Clear Cell Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 14/100 (14%) 17/100 (17%) 14/100 (14%) 11/98 (11%) |4/98 (4%) 3/97 (3%) 8/98 (8%) 6/99 (6%) | |POLY-3 ADJUSTED (b)| 15.0% 19.0% 15.1% 12.9% |4.5% 3.4% 8.8% 6.7% | |TERMINAL (d) | 13/76 (17%) 16/72 (22%) 14/84 (17%) 10/62 (16%) |3/70 (4%) 3/74 (4%) 6/79 (8%) 5/74 (7%) | |FIRST INCIDENCE | 520 522 734 (T) 525 |608 735 (T) 472 597 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.372N P=0.290 P=0.471N P=0.535N |P=0.319 P=0.475N P=0.237 P=0.398 | |POLY 3 | P=0.251N P=0.301 P=0.580 P=0.424N |P=0.316 P=0.508N P=0.193 P=0.373 | |POLY 1.5 | P=0.229N P=0.320 P=0.579 P=0.395N |P=0.316 P=0.508N P=0.191 P=0.372 | |POLY 6 | P=0.278N P=0.281 P=0.576N P=0.458N |P=0.318 P=0.509N P=0.193 P=0.374 | |LOGISTIC REGRESSION| P=0.264N P=0.297 P=0.567N P=0.426N |P=0.323 P=0.506N P=0.184 P=0.376 | |COCH-ARM / FISHERS | P=0.200N P=0.348 P=0.581N P=0.355N |P=0.324 P=0.506N P=0.186 P=0.380 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Developmental Malformation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/98 (0%) |0/98 (0%) 1/97 (1%) 2/98 (2%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 1.1% 2.2% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 2/79 (3%) 0/74 (0%) | |FIRST INCIDENCE | --- --- --- --- |--- 64 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.441N P=0.500 P=0.266 (e) | |POLY 3 | (e) (e) (e) (e) |P=0.445N P=0.500 P=0.240 (e) | |POLY 1.5 | (e) (e) (e) (e) |P=0.445N P=0.500 P=0.240 (e) | |POLY 6 | (e) (e) (e) (e) |P=0.444N P=0.501 P=0.240 (e) | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.383N (e) P=0.266 (e) | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.440N P=0.497 P=0.249 (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 26 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Eosinophilic Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 12/100 (12%) 13/100 (13%) 15/100 (15%) 15/98 (15%) |6/98 (6%) 4/97 (4%) 10/98 (10%) 11/99 (11%) | |POLY-3 ADJUSTED (b)| 12.9% 14.7% 16.0% 17.7% |6.6% 4.5% 11.1% 12.3% | |TERMINAL (d) | 10/76 (13%) 13/72 (18%) 13/84 (16%) 13/62 (21%) |5/70 (7%) 4/74 (5%) 10/79 (13%) 9/74 (12%) | |FIRST INCIDENCE | 520 734 (T) 549 630 |397 735 (T) 735 (T) 687 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.150 P=0.443 P=0.433 P=0.170 |P=0.071 P=0.342N P=0.291 P=0.183 | |POLY 3 | P=0.260 P=0.447 P=0.347 P=0.249 |P=0.067 P=0.385N P=0.216 P=0.150 | |POLY 1.5 | P=0.285 P=0.469 P=0.343 P=0.276 |P=0.067 P=0.384N P=0.216 P=0.151 | |POLY 6 | P=0.232 P=0.423 P=0.357 P=0.219 |P=0.067 P=0.385N P=0.213 P=0.150 | |LOGISTIC REGRESSION| P=0.240 P=0.438 P=0.341 P=0.234 |P=0.068 P=0.379N P=0.219 P=0.156 | |COCH-ARM / FISHERS | P=0.324 P=0.500 P=0.340 P=0.319 |P=0.073 P=0.380N P=0.217 P=0.160 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Hepatodiaphragmatic Nodule | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 2/98 (2%) |0/98 (0%) 0/97 (0%) 1/98 (1%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.4% |0.0% 0.0% 1.1% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 2/62 (3%) |0/70 (0%) 0/74 (0%) 1/79 (1%) 0/74 (0%) | |FIRST INCIDENCE | --- --- --- 734 (T) |--- --- 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.026 * (e) (e) P=0.195 |P=0.766N (e) P=0.524 (e) | |POLY 3 | P=0.038 * (e) (e) P=0.219 |P=0.766N (e) P=0.502 (e) | |POLY 1.5 | P=0.039 * (e) (e) P=0.225 |P=0.766N (e) P=0.501 (e) | |POLY 6 | P=0.036 * (e) (e) P=0.212 |P=0.765N (e) P=0.501 (e) | |LOGISTIC REGRESSION| (e) (e) (e) P=0.195 |(e) (e) P=0.524 (e) | |COCH-ARM / FISHERS | P=0.041 * (e) (e) P=0.244 |P=0.764N (e) P=0.500 (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 27 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Infiltration Cellular Focal Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/100 (6%) 10/100 (10%) 14/100 (14%) 10/98 (10%) |53/98 (54%) 58/97 (60%) 48/98 (49%) 48/99 (48%) | |POLY-3 ADJUSTED (b)| 6.5% 11.3% 15.1% 11.8% |58.9% 64.3% 52.3% 52.7% | |TERMINAL (d) | 6/76 (8%) 9/72 (13%) 14/84 (17%) 8/62 (13%) |47/70 (67%) 53/74 (72%) 44/79 (56%) 41/74 (55%) | |FIRST INCIDENCE | 734 (T) 703 734 (T) 594 |666 387 513 566 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.240 P=0.184 P=0.076 P=0.117 |P=0.124N P=0.429 P=0.078N P=0.171N | |POLY 3 | P=0.356 P=0.192 P=0.049 * P=0.168 |P=0.125N P=0.272 P=0.226N P=0.242N | |POLY 1.5 | P=0.379 P=0.202 P=0.049 * P=0.183 |P=0.135N P=0.263 P=0.245N P=0.260N | |POLY 6 | P=0.330 P=0.182 P=0.051 P=0.153 |P=0.108N P=0.276 P=0.219N P=0.219N | |LOGISTIC REGRESSION| P=0.307 P=0.175 P=0.076 P=0.149 |P=0.142N P=0.238 P=0.265N P=0.276N | |COCH-ARM / FISHERS | P=0.413 P=0.218 P=0.049 * P=0.205 |P=0.129N P=0.254 P=0.284N P=0.260N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Mixed Cell Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/100 (4%) 1/100 (1%) 3/100 (3%) 4/98 (4%) |0/98 (0%) 1/97 (1%) 2/98 (2%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| 4.3% 1.1% 3.2% 4.7% |0.0% 1.1% 2.2% 1.1% | |TERMINAL (d) | 4/76 (5%) 1/72 (1%) 3/84 (4%) 3/62 (5%) |0/70 (0%) 1/74 (1%) 2/79 (3%) 1/74 (1%) | |FIRST INCIDENCE | 734 (T) 734 (T) 734 (T) 545 |--- 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.235 P=0.199N P=0.446N P=0.536 |P=0.601 P=0.511 P=0.266 P=0.511 | |POLY 3 | P=0.304 P=0.195N P=0.497N P=0.595 |P=0.596 P=0.498 P=0.240 P=0.500 | |POLY 1.5 | P=0.312 P=0.190N P=0.498N P=0.609 |P=0.596 P=0.498 P=0.240 P=0.500 | |POLY 6 | P=0.294 P=0.201N P=0.492N P=0.579 |P=0.597 P=0.498 P=0.240 P=0.500 | |LOGISTIC REGRESSION| P=0.294 P=0.199N P=0.446N P=0.608 |(e) P=0.511 P=0.266 P=0.511 | |COCH-ARM / FISHERS | P=0.324 P=0.184N P=0.500N P=0.628 |P=0.601 P=0.497 P=0.249 P=0.503 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 28 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Necrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 7/100 (7%) 6/100 (6%) 4/100 (4%) 4/98 (4%) |4/98 (4%) 2/97 (2%) 4/98 (4%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 7.4% 6.7% 4.3% 4.7% |4.4% 2.2% 4.4% 0.0% | |TERMINAL (d) | 1/76 (1%) 3/72 (4%) 2/84 (2%) 2/62 (3%) |0/70 (0%) 0/74 (0%) 2/79 (3%) 0/74 (0%) | |FIRST INCIDENCE | 520 461 585 703 |432 545 638 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.359N P=0.541N P=0.260N P=0.356N |P=0.084N P=0.346N P=0.626N P=0.069N | |POLY 3 | P=0.331N P=0.537N P=0.272N P=0.333N |P=0.083N P=0.348N P=0.638 P=0.066N | |POLY 1.5 | P=0.313N P=0.521N P=0.271N P=0.311N |P=0.082N P=0.347N P=0.639 P=0.065N | |POLY 6 | P=0.352N P=0.557N P=0.273N P=0.362N |P=0.084N P=0.349N P=0.635 P=0.067N | |LOGISTIC REGRESSION| P=0.218N P=0.384N P=0.262N P=0.208N |P=0.067N P=0.307N P=0.638N P=0.043N* | |COCH-ARM / FISHERS | P=0.288N P=0.500N P=0.269N P=0.280N |P=0.078N P=0.346N P=0.640N P=0.059N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver: Hepatocyte | | Vacuolization Cytoplasmic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 13/100 (13%) 9/100 (9%) 6/100 (6%) 6/98 (6%) |14/98 (14%) 15/97 (15%) 14/98 (14%) 17/99 (17%) | |POLY-3 ADJUSTED (b)| 13.7% 9.9% 6.5% 6.9% |14.9% 16.4% 15.3% 18.2% | |TERMINAL (d) | 8/76 (11%) 5/72 (7%) 6/84 (7%) 2/62 (3%) |6/70 (9%) 6/74 (8%) 10/79 (13%) 11/74 (15%) | |FIRST INCIDENCE | 386 400 734 (T) 500 |288 491 578 291 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.211N P=0.291N P=0.056N P=0.137N |P=0.331 P=0.526 P=0.500N P=0.384 | |POLY 3 | P=0.161N P=0.283N P=0.080N P=0.105N |P=0.327 P=0.474 P=0.556 P=0.342 | |POLY 1.5 | P=0.152N P=0.270N P=0.078N P=0.095N |P=0.327 P=0.474 P=0.563 P=0.343 | |POLY 6 | P=0.173N P=0.298N P=0.080N P=0.118N |P=0.324 P=0.479 P=0.548 P=0.341 | |LOGISTIC REGRESSION| P=0.074N P=0.141N P=0.073N P=0.019N* |P=0.385 P=0.499 P=0.564 P=0.418 | |COCH-ARM / FISHERS | P=0.139N P=0.249N P=0.073N P=0.080N |P=0.336 P=0.488 P=0.581N P=0.360 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 29 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lung | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 20/100 (20%) 16/99 (16%) 22/100 (22%) 24/99 (24%) |32/95 (34%) 37/100 (37%) 33/99 (33%) 34/99 (34%) | |POLY-3 ADJUSTED (b)| 21.5% 18.1% 23.5% 27.3% |36.5% 39.8% 36.0% 37.4% | |TERMINAL (d) | 19/76 (25%) 15/72 (21%) 21/84 (25%) 17/62 (27%) |30/70 (43%) 29/74 (39%) 31/79 (39%) 26/74 (35%) | |FIRST INCIDENCE | 497 719 590 480 |667 387 645 566 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.031 * P=0.349N P=0.569 P=0.116 |P=0.491N P=0.364 P=0.398N P=0.538 | |POLY 3 | P=0.118 P=0.353N P=0.436 P=0.230 |P=0.509N P=0.379 P=0.536N P=0.512 | |POLY 1.5 | P=0.129 P=0.332N P=0.432 P=0.253 |P=0.516N P=0.372 P=0.538N P=0.502 | |POLY 6 | P=0.107 P=0.375N P=0.449 P=0.208 |P=0.490N P=0.383 P=0.545N P=0.529 | |LOGISTIC REGRESSION| P=0.093 P=0.368N P=0.445 P=0.238 |P=0.514N P=0.338 P=0.560 P=0.486 | |COCH-ARM / FISHERS | P=0.148 P=0.302N P=0.431 P=0.291 |P=0.489N P=0.369 P=0.540N P=0.522 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lung | | Inflammation Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 3/99 (3%) 1/100 (1%) 3/99 (3%) |2/95 (2%) 1/100 (1%) 1/99 (1%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 3.4% 1.1% 3.5% |2.3% 1.1% 1.1% 1.1% | |TERMINAL (d) | 0/76 (0%) 1/72 (1%) 1/84 (1%) 3/62 (5%) |1/70 (1%) 1/74 (1%) 1/79 (1%) 1/74 (1%) | |FIRST INCIDENCE | --- 461 734 (T) 734 (T) |733 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.198 P=0.118 P=0.520 P=0.089 |P=0.537N P=0.481N P=0.460N P=0.479N | |POLY 3 | P=0.232 P=0.115 P=0.501 P=0.108 |P=0.541N P=0.488N P=0.486N P=0.492N | |POLY 1.5 | P=0.241 P=0.117 P=0.501 P=0.113 |P=0.541N P=0.487N P=0.486N P=0.492N | |POLY 6 | P=0.221 P=0.114 P=0.503 P=0.103 |P=0.539N P=0.490N P=0.487N P=0.492N | |LOGISTIC REGRESSION| P=0.288 P=0.153 P=0.520 P=0.089 |P=0.537N P=0.489N P=0.483N P=0.487N | |COCH-ARM / FISHERS | P=0.255 P=0.121 P=0.500 P=0.121 |P=0.538N P=0.481N P=0.484N P=0.484N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 30 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lung: Alveolar Epithelium | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 2/99 (2%) 0/100 (0%) 3/99 (3%) |4/95 (4%) 1/100 (1%) 2/99 (2%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 2.2% 2.3% 0.0% 3.5% |4.5% 1.1% 2.2% 0.0% | |TERMINAL (d) | 2/76 (3%) 2/72 (3%) 0/84 (0%) 2/62 (3%) |3/70 (4%) 1/74 (1%) 2/79 (3%) 0/74 (0%) | |FIRST INCIDENCE | 734 (T) 734 (T) --- 510 |432 735 (T) 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.247 P=0.674 P=0.217N P=0.422 |P=0.111N P=0.170N P=0.294N P=0.061N | |POLY 3 | P=0.302 P=0.676 P=0.237N P=0.468 |P=0.112N P=0.175N P=0.325N P=0.062N | |POLY 1.5 | P=0.309 P=0.681 P=0.238N P=0.479 |P=0.113N P=0.173N P=0.324N P=0.061N | |POLY 6 | P=0.294 P=0.670 P=0.235N P=0.455 |P=0.110N P=0.177N P=0.328N P=0.062N | |LOGISTIC REGRESSION| P=0.320 P=0.674 (e) P=0.516 |P=0.110N P=0.156N P=0.315N P=0.049N* | |COCH-ARM / FISHERS | P=0.319 P=0.686 P=0.249N P=0.495 |P=0.112N P=0.169N P=0.322N P=0.056N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lung: Alveolus | | Infiltration Cellular Histiocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 5/99 (5%) 4/100 (4%) 3/99 (3%) |1/95 (1%) 4/100 (4%) 1/99 (1%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 3.2% 5.6% 4.3% 3.5% |1.1% 4.4% 1.1% 2.2% | |TERMINAL (d) | 2/76 (3%) 4/72 (6%) 4/84 (5%) 1/62 (2%) |0/70 (0%) 3/74 (4%) 1/79 (1%) 1/74 (1%) | |FIRST INCIDENCE | 715 612 734 (T) 568 |723 559 735 (T) 687 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.535N P=0.329 P=0.549 P=0.580 |P=0.565N P=0.195 P=0.744N P=0.508 | |POLY 3 | P=0.463N P=0.336 P=0.503 P=0.627 |P=0.571N P=0.194 P=0.751N P=0.509 | |POLY 1.5 | P=0.449N P=0.343 P=0.501 P=0.639 |P=0.570N P=0.195 P=0.751N P=0.509 | |POLY 6 | P=0.479N P=0.329 P=0.507 P=0.613 |P=0.569N P=0.193 P=0.753N P=0.509 | |LOGISTIC REGRESSION| P=0.449N P=0.337 P=0.518 P=0.657 |P=0.565N P=0.200 P=0.754N P=0.510 | |COCH-ARM / FISHERS | P=0.428N P=0.355 P=0.500 P=0.654 |P=0.564N P=0.201 P=0.741N P=0.516 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 31 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lung: Artery | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/99 (0%) 0/100 (0%) 0/99 (0%) |2/95 (2%) 0/100 (0%) 0/99 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |2.3% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | --- --- --- --- |625 --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.366N P=0.238N P=0.236N P=0.240N | |POLY 3 | (e) (e) (e) (e) |P=0.359N P=0.232N P=0.230N P=0.235N | |POLY 1.5 | (e) (e) (e) (e) |P=0.361N P=0.231N P=0.230N P=0.234N | |POLY 6 | (e) (e) (e) (e) |P=0.357N P=0.234N P=0.232N P=0.235N | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.354N P=0.215N P=0.222N P=0.215N | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.362N P=0.236N P=0.239N P=0.239N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node | | Ectasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/6 (0%) 0/6 (0%) 0/5 (0%) 0/3 (0%) |2/19 (11%) 2/15 (13%) 2/4 (50%) 1/14 (7%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |11.2% 14.0% 50.0% 7.7% | |TERMINAL (d) | 0/6 (0%) 0/3 (0%) 0/3 (0%) 0/0 (0%) |2/11 (18%) 1/11 (9%) 2/4 (50%) 1/10 (10%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 673 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.389N P=0.696 P=0.290 P=0.535N | |POLY 3 | (e) (e) (e) (e) |P=0.438N P=0.612 P=0.122 P=0.612N | |POLY 1.5 | (e) (e) (e) (e) |P=0.435N P=0.610 P=0.117 P=0.611N | |POLY 6 | (e) (e) (e) (e) |P=0.438N P=0.620 P=0.129 P=0.611N | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.435N P=0.610 P=0.290 P=0.535N | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.429N P=0.603 P=0.125 P=0.616N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 32 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/92 (4%) 2/92 (2%) 3/92 (3%) 4/89 (4%) |3/84 (4%) 7/94 (7%) 4/89 (4%) 4/91 (4%) | |POLY-3 ADJUSTED (b)| 4.6% 2.4% 3.5% 5.1% |3.8% 8.0% 4.8% 4.8% | |TERMINAL (d) | 1/72 (1%) 1/66 (2%) 1/79 (1%) 1/57 (2%) |0/66 (0%) 2/71 (3%) 1/74 (1%) 3/72 (4%) | |FIRST INCIDENCE | 582 722 636 604 |707 461 655 597 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.338 P=0.369N P=0.474N P=0.560 |P=0.447N P=0.185 P=0.516 P=0.527 | |POLY 3 | P=0.378 P=0.367N P=0.504N P=0.584 |P=0.446N P=0.210 P=0.535 P=0.537 | |POLY 1.5 | P=0.387 P=0.356N P=0.503N P=0.600 |P=0.445N P=0.210 P=0.532 P=0.537 | |POLY 6 | P=0.366 P=0.381N P=0.503N P=0.565 |P=0.447N P=0.209 P=0.536 P=0.536 | |LOGISTIC REGRESSION| P=0.430 P=0.314N P=0.492N P=0.590N |P=0.429N P=0.237 P=0.534 P=0.542 | |COCH-ARM / FISHERS | P=0.399 P=0.341N P=0.500N P=0.621 |P=0.438N P=0.215 P=0.532 P=0.544 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/92 (0%) 0/92 (0%) 0/92 (0%) 1/89 (1%) |2/84 (2%) 2/94 (2%) 1/89 (1%) 2/91 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 1.3% |2.6% 2.3% 1.2% 2.4% | |TERMINAL (d) | 0/72 (0%) 0/66 (0%) 0/79 (0%) 0/57 (0%) |2/66 (3%) 1/71 (1%) 0/74 (0%) 2/72 (3%) | |FIRST INCIDENCE | --- --- --- 671 |735 (T) 547 692 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.219 (e) (e) P=0.476 |P=0.619 P=0.675N P=0.476N P=0.662N | |POLY 3 | P=0.221 (e) (e) P=0.480 |P=0.615 P=0.659N P=0.479N P=0.670N | |POLY 1.5 | P=0.224 (e) (e) P=0.486 |P=0.615 P=0.657N P=0.480N P=0.669N | |POLY 6 | P=0.217 (e) (e) P=0.473 |P=0.615 P=0.660N P=0.480N P=0.670N | |LOGISTIC REGRESSION| P=0.242 (e) (e) P=0.518 |P=0.619 P=0.643N P=0.480N P=0.662N | |COCH-ARM / FISHERS | P=0.227 (e) (e) P=0.492 |P=0.618 P=0.646N P=0.478N P=0.659N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 33 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/92 (1%) 4/92 (4%) 1/92 (1%) 1/89 (1%) |8/84 (10%) 10/94 (11%) 12/89 (13%) 4/91 (4%) | |POLY-3 ADJUSTED (b)| 1.2% 4.9% 1.2% 1.3% |10.2% 11.6% 14.4% 4.8% | |TERMINAL (d) | 1/72 (1%) 2/66 (3%) 1/79 (1%) 1/57 (2%) |8/66 (12%) 9/71 (13%) 12/74 (16%) 4/72 (6%) | |FIRST INCIDENCE | 734 (T) 589 734 (T) 734 (T) |735 (T) 387 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.390N P=0.167 P=0.740N P=0.708 |P=0.056N P=0.463 P=0.327 P=0.144N | |POLY 3 | P=0.360N P=0.169 P=0.760 P=0.737 |P=0.064N P=0.488 P=0.282 P=0.154N | |POLY 1.5 | P=0.350N P=0.174 P=0.760 P=0.744 |P=0.064N P=0.492 P=0.281 P=0.154N | |POLY 6 | P=0.373N P=0.164 P=0.760N P=0.729 |P=0.063N P=0.483 P=0.279 P=0.155N | |LOGISTIC REGRESSION| P=0.343N P=0.184 P=0.740N P=0.708 |P=0.063N P=0.490 P=0.327 P=0.144N | |COCH-ARM / FISHERS | P=0.335N P=0.184 P=0.751N P=0.743 |P=0.062N P=0.503 P=0.283 P=0.149N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Hyperplasia Reticulum Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/92 (0%) 0/92 (0%) 0/92 (0%) 0/89 (0%) |0/84 (0%) 2/94 (2%) 1/89 (1%) 2/91 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 2.3% 1.2% 2.4% | |TERMINAL (d) | 0/72 (0%) 0/66 (0%) 0/79 (0%) 0/57 (0%) |0/66 (0%) 2/71 (3%) 1/74 (1%) 2/72 (3%) | |FIRST INCIDENCE | --- --- --- --- |--- 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.385 P=0.255 P=0.523 P=0.258 | |POLY 3 | (e) (e) (e) (e) |P=0.375 P=0.258 P=0.512 P=0.253 | |POLY 1.5 | (e) (e) (e) (e) |P=0.376 P=0.260 P=0.511 P=0.253 | |POLY 6 | (e) (e) (e) (e) |P=0.375 P=0.256 P=0.511 P=0.252 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) P=0.255 P=0.523 P=0.258 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.380 P=0.277 P=0.514 P=0.269 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 34 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Infiltration Cellular Mast Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/92 (1%) 0/92 (0%) 1/92 (1%) 7/89 (8%) |0/84 (0%) 0/94 (0%) 0/89 (0%) 0/91 (0%) | |POLY-3 ADJUSTED (b)| 1.2% 0.0% 1.2% 8.6% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 1/72 (1%) 0/66 (0%) 0/79 (0%) 2/57 (4%) |0/66 (0%) 0/71 (0%) 0/74 (0%) 0/72 (0%) | |FIRST INCIDENCE | 734 (T) --- 449 448 |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P<0.001 ** P=0.517N P=0.750N P=0.027 * |(e) (e) (e) (e) | |POLY 3 | P<0.001 ** P=0.510N P=0.759N P=0.028 * |(e) (e) (e) (e) | |POLY 1.5 | P<0.001 ** P=0.506N P=0.760N P=0.029 * |(e) (e) (e) (e) | |POLY 6 | P<0.001 ** P=0.515N P=0.757N P=0.026 * |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P<0.001 ** (e) P=0.762N P=0.078 |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P<0.001 ** P=0.500N P=0.751N P=0.029 * |(e) (e) (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Infiltration Cellular Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/92 (4%) 2/92 (2%) 0/92 (0%) 3/89 (3%) |2/84 (2%) 1/94 (1%) 2/89 (2%) 1/91 (1%) | |POLY-3 ADJUSTED (b)| 4.7% 2.4% 0.0% 3.9% |2.6% 1.2% 2.4% 1.2% | |TERMINAL (d) | 2/72 (3%) 0/66 (0%) 0/79 (0%) 1/57 (2%) |2/66 (3%) 1/71 (1%) 2/74 (3%) 0/72 (0%) | |FIRST INCIDENCE | 705 665 --- 705 |735 (T) 735 (T) 735 (T) 690 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.450 P=0.374N P=0.057N P=0.607N |P=0.486N P=0.475N P=0.652N P=0.483N | |POLY 3 | P=0.499 P=0.361N P=0.064N P=0.555N |P=0.490N P=0.469N P=0.672N P=0.477N | |POLY 1.5 | P=0.506 P=0.352N P=0.064N P=0.539N |P=0.491N P=0.467N P=0.672N P=0.476N | |POLY 6 | P=0.489 P=0.371N P=0.063N P=0.574N |P=0.487N P=0.472N P=0.673N P=0.477N | |LOGISTIC REGRESSION| P=0.495 P=0.353N P=0.064N P=0.575N |P=0.491N P=0.475N P=0.652N P=0.476N | |COCH-ARM / FISHERS | P=0.516 P=0.341N P=0.060N P=0.518N |P=0.490N P=0.458N P=0.668N P=0.470N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 35 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Infiltration Cellular Plasma Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/92 (0%) 2/92 (2%) 3/92 (3%) 2/89 (2%) |2/84 (2%) 1/94 (1%) 2/89 (2%) 1/91 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 2.4% 3.5% 2.6% |2.6% 1.2% 2.4% 1.2% | |TERMINAL (d) | 0/72 (0%) 2/66 (3%) 2/79 (3%) 0/57 (0%) |2/66 (3%) 1/71 (1%) 1/74 (1%) 1/72 (1%) | |FIRST INCIDENCE | --- 734 (T) 590 577 |735 (T) 735 (T) 578 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.397 P=0.220 P=0.134 P=0.218 |P=0.488N P=0.475N P=0.660N P=0.470N | |POLY 3 | P=0.424 P=0.227 P=0.122 P=0.218 |P=0.491N P=0.469N P=0.670N P=0.478N | |POLY 1.5 | P=0.434 P=0.232 P=0.122 P=0.224 |P=0.491N P=0.467N P=0.671N P=0.477N | |POLY 6 | P=0.412 P=0.223 P=0.123 P=0.212 |P=0.490N P=0.472N P=0.670N P=0.478N | |LOGISTIC REGRESSION| P=0.478 P=0.220 P=0.124 P=0.292 |P=0.491N P=0.475N P=0.670N P=0.470N | |COCH-ARM / FISHERS | P=0.448 P=0.249 P=0.123 P=0.240 |P=0.490N P=0.458N P=0.668N P=0.470N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/92 (2%) 4/92 (4%) 3/92 (3%) 2/89 (2%) |22/84 (26%) 9/94 (10%) 18/89 (20%) 10/91 (11%) | |POLY-3 ADJUSTED (b)| 2.3% 4.9% 3.5% 2.6% |27.9% 10.3% 21.5% 11.9% | |TERMINAL (d) | 1/72 (1%) 3/66 (5%) 3/79 (4%) 2/57 (4%) |18/66 (27%) 5/71 (7%) 16/74 (22%) 8/72 (11%) | |FIRST INCIDENCE | 603 719 734 (T) 734 (T) |667 461 645 687 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.516N P=0.309 P=0.531 P=0.619 |P=0.087N P=0.007N** P=0.189N P=0.010N* | |POLY 3 | P=0.463N P=0.315 P=0.497 P=0.653 |P=0.092N P=0.003N** P=0.222N P=0.008N** | |POLY 1.5 | P=0.449N P=0.325 P=0.498 P=0.665 |P=0.090N P=0.003N** P=0.225N P=0.008N** | |POLY 6 | P=0.481N P=0.303 P=0.497 P=0.639 |P=0.092N P=0.003N** P=0.225N P=0.008N** | |LOGISTIC REGRESSION| P=0.460N P=0.332 P=0.501 P=0.687 |P=0.089N P=0.003N** P=0.226N P=0.009N** | |COCH-ARM / FISHERS | P=0.430N P=0.341 P=0.500 P=0.677 |P=0.087N P=0.003N** P=0.227N P=0.008N** | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 36 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/87 (7%) 12/90 (13%) 14/96 (15%) 7/85 (8%) |12/83 (14%) 10/88 (11%) 24/89 (27%) 21/92 (23%) | |POLY-3 ADJUSTED (b)| 7.3% 14.4% 15.3% 9.1% |15.0% 12.1% 28.8% 24.4% | |TERMINAL (d) | 3/70 (4%) 6/70 (9%) 12/83 (15%) 4/61 (7%) |9/68 (13%) 7/71 (10%) 22/75 (29%) 17/72 (24%) | |FIRST INCIDENCE | 497 560 549 568 |667 491 659 474 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.406N P=0.106 P=0.091 P=0.407 |P=0.051 P=0.382N P=0.039 * P=0.088 | |POLY 3 | P=0.360N P=0.109 P=0.075 P=0.445 |P=0.061 P=0.373N P=0.026 * P=0.094 | |POLY 1.5 | P=0.342N P=0.114 P=0.075 P=0.459 |P=0.064 P=0.369N P=0.028 * P=0.099 | |POLY 6 | P=0.379N P=0.106 P=0.077 P=0.430 |P=0.057 P=0.375N P=0.023 * P=0.089 | |LOGISTIC REGRESSION| P=0.299N P=0.135 P=0.075 P=0.523 |P=0.067 P=0.353N P=0.027 * P=0.100 | |COCH-ARM / FISHERS | P=0.315N P=0.121 P=0.076 P=0.482 |P=0.072 P=0.353N P=0.033 * P=0.111 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Ectasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/87 (0%) 0/90 (0%) 0/96 (0%) 0/85 (0%) |3/83 (4%) 0/88 (0%) 4/89 (4%) 2/92 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |3.8% 0.0% 4.8% 2.3% | |TERMINAL (d) | 0/70 (0%) 0/70 (0%) 0/83 (0%) 0/61 (0%) |3/68 (4%) 0/71 (0%) 4/75 (5%) 2/72 (3%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) --- 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.611 P=0.115N P=0.553 P=0.474N | |POLY 3 | (e) (e) (e) (e) |P=0.625 P=0.115N P=0.524 P=0.468N | |POLY 1.5 | (e) (e) (e) (e) |P=0.626N P=0.114N P=0.528 P=0.464N | |POLY 6 | (e) (e) (e) (e) |P=0.622 P=0.116N P=0.518 P=0.472N | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.611 (e) P=0.553 P=0.474N | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.623N P=0.112N P=0.539 P=0.451N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 37 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/87 (3%) 2/90 (2%) 3/96 (3%) 3/85 (4%) |3/83 (4%) 2/88 (2%) 4/89 (4%) 4/92 (4%) | |POLY-3 ADJUSTED (b)| 3.7% 2.4% 3.3% 3.9% |3.8% 2.4% 4.8% 4.7% | |TERMINAL (d) | 2/70 (3%) 1/70 (1%) 3/83 (4%) 3/61 (5%) |3/68 (4%) 2/71 (3%) 3/75 (4%) 3/72 (4%) | |FIRST INCIDENCE | 684 719 734 (T) 734 (T) |735 (T) 735 (T) 692 721 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.443 P=0.510N P=0.593N P=0.596 |P=0.379 P=0.480N P=0.543 P=0.529 | |POLY 3 | P=0.481 P=0.496N P=0.614N P=0.628 |P=0.399 P=0.486N P=0.525 P=0.539 | |POLY 1.5 | P=0.489 P=0.492N P=0.614N P=0.636 |P=0.403 P=0.483N P=0.528 P=0.543 | |POLY 6 | P=0.473 P=0.502N P=0.611N P=0.619 |P=0.396 P=0.488N P=0.520 P=0.535 | |LOGISTIC REGRESSION| P=0.472 P=0.494N P=0.612N P=0.623 |P=0.395 P=0.480N P=0.520 P=0.532 | |COCH-ARM / FISHERS | P=0.501 P=0.484N P=0.611N P=0.648 |P=0.408 P=0.472N P=0.539 P=0.557 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/87 (0%) 7/90 (8%) 5/96 (5%) 1/85 (1%) |2/83 (2%) 1/88 (1%) 4/89 (4%) 0/92 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 8.5% 5.5% 1.3% |2.5% 1.2% 4.8% 0.0% | |TERMINAL (d) | 0/70 (0%) 7/70 (10%) 5/83 (6%) 1/61 (2%) |2/68 (3%) 1/71 (1%) 3/75 (4%) 0/72 (0%) | |FIRST INCIDENCE | --- 734 (T) 734 (T) 734 (T) |735 (T) 735 (T) 21 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.202N P=0.010 * P=0.052 P=0.473 |P=0.196N P=0.485N P=0.377 P=0.226N | |POLY 3 | P=0.184N P=0.010 * P=0.043 * P=0.486 |P=0.188N P=0.489N P=0.365 P=0.222N | |POLY 1.5 | P=0.177N P=0.010 * P=0.043 * P=0.490 |P=0.186N P=0.487N P=0.369 P=0.221N | |POLY 6 | P=0.192N P=0.009 ** P=0.044 * P=0.483 |P=0.190N P=0.491N P=0.360 P=0.224N | |LOGISTIC REGRESSION| (e) P=0.010 * P=0.052 P=0.473 |P=0.168N P=0.485N P=0.469 (e) | |COCH-ARM / FISHERS | P=0.168N P=0.008 ** P=0.038 * P=0.494 |P=0.184N P=0.478N P=0.375 P=0.224N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 38 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Hyperplasia Reticulum Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/87 (0%) 0/90 (0%) 0/96 (0%) 0/85 (0%) |3/83 (4%) 7/88 (8%) 13/89 (15%) 8/92 (9%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |3.8% 8.6% 15.6% 9.4% | |TERMINAL (d) | 0/70 (0%) 0/70 (0%) 0/83 (0%) 0/61 (0%) |3/68 (4%) 7/71 (10%) 12/75 (16%) 8/72 (11%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 735 (T) 645 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.361 P=0.181 P=0.015 * P=0.124 | |POLY 3 | (e) (e) (e) (e) |P=0.383 P=0.177 P=0.011 * P=0.130 | |POLY 1.5 | (e) (e) (e) (e) |P=0.390 P=0.179 P=0.011 * P=0.133 | |POLY 6 | (e) (e) (e) (e) |P=0.376 P=0.174 P=0.010 * P=0.126 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.383 P=0.181 P=0.011 * P=0.124 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.406 P=0.190 P=0.012 * P=0.142 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Infiltration Cellular Histiocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 59/87 (68%) 67/90 (74%) 79/96 (82%) 56/85 (66%) |50/83 (60%) 45/88 (51%) 47/89 (53%) 43/92 (47%) | |POLY-3 ADJUSTED (b)| 70.4% 78.1% 84.9% 70.3% |61.7% 53.9% 55.3% 49.4% | |TERMINAL (d) | 50/70 (71%) 57/70 (81%) 72/83 (87%) 42/61 (69%) |44/68 (65%) 39/71 (55%) 42/75 (56%) 37/72 (51%) | |FIRST INCIDENCE | 520 400 527 458 |397 496 472 531 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.532 P=0.131 P=0.092 P=0.298 |P=0.198N P=0.195N P=0.177N P=0.110N | |POLY 3 | P=0.185N P=0.159 P=0.014 * P=0.559N |P=0.121N P=0.191N P=0.247N P=0.071N | |POLY 1.5 | P=0.163N P=0.180 P=0.014 * P=0.520N |P=0.116N P=0.183N P=0.236N P=0.065N | |POLY 6 | P=0.203N P=0.138 P=0.015 * P=0.553 |P=0.126N P=0.197N P=0.264N P=0.076N | |LOGISTIC REGRESSION| P=0.222N P=0.147 P=0.015 * P=0.536 |P=0.118N P=0.181N P=0.235N P=0.066N | |COCH-ARM / FISHERS | P=0.134N P=0.210 P=0.018 * P=0.457N |P=0.104N P=0.148N P=0.204N P=0.051N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 39 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Infiltration Cellular Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/87 (3%) 5/90 (6%) 2/96 (2%) 3/85 (4%) |4/83 (5%) 1/88 (1%) 2/89 (2%) 5/92 (5%) | |POLY-3 ADJUSTED (b)| 3.7% 6.0% 2.2% 3.9% |5.0% 1.2% 2.4% 5.9% | |TERMINAL (d) | 3/70 (4%) 4/70 (6%) 2/83 (2%) 3/61 (5%) |4/68 (6%) 1/71 (1%) 2/75 (3%) 5/72 (7%) | |FIRST INCIDENCE | 734 (T) 629 734 (T) 734 (T) |735 (T) 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.568N P=0.354 P=0.423N P=0.597 |P=0.168 P=0.169N P=0.295N P=0.535 | |POLY 3 | P=0.527N P=0.366 P=0.454N P=0.629 |P=0.185 P=0.172N P=0.319N P=0.544 | |POLY 1.5 | P=0.519N P=0.371 P=0.455N P=0.637 |P=0.187 P=0.171N P=0.316N P=0.549 | |POLY 6 | P=0.536N P=0.363 P=0.450N P=0.621 |P=0.183 P=0.174N P=0.324N P=0.539 | |LOGISTIC REGRESSION| P=0.533N P=0.366 P=0.423N P=0.597 |P=0.168 P=0.169N P=0.295N P=0.535 | |COCH-ARM / FISHERS | P=0.505N P=0.379 P=0.453N P=0.648 |P=0.189 P=0.166N P=0.308N P=0.565 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Infiltration Cellular Plasma Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/87 (0%) 0/90 (0%) 0/96 (0%) 0/85 (0%) |5/83 (6%) 4/88 (5%) 2/89 (2%) 1/92 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |6.3% 4.9% 2.4% 1.2% | |TERMINAL (d) | 0/70 (0%) 0/70 (0%) 0/83 (0%) 0/61 (0%) |5/68 (7%) 4/71 (6%) 2/75 (3%) 1/72 (1%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.093N P=0.473N P=0.183N P=0.094N | |POLY 3 | (e) (e) (e) (e) |P=0.088N P=0.481N P=0.202N P=0.089N | |POLY 1.5 | (e) (e) (e) (e) |P=0.087N P=0.477N P=0.200N P=0.088N | |POLY 6 | (e) (e) (e) (e) |P=0.089N P=0.484N P=0.207N P=0.091N | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.093N P=0.473N P=0.183N P=0.094N | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.086N P=0.463N P=0.194N P=0.083N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 40 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node: Lumbar | | Ectasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/6 (0%) 0/6 (0%) 0/5 (0%) 0/3 (0%) |3/19 (16%) 1/15 (7%) 1/4 (25%) 2/14 (14%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |16.8% 7.1% 25.0% 15.2% | |TERMINAL (d) | 0/6 (0%) 0/3 (0%) 0/3 (0%) 0/0 (0%) |3/11 (27%) 1/11 (9%) 1/4 (25%) 1/10 (10%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 735 (T) 735 (T) 684 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.610 P=0.295N P=0.710N P=0.540N | |POLY 3 | (e) (e) (e) (e) |P=0.573 P=0.393N P=0.627 P=0.643N | |POLY 1.5 | (e) (e) (e) (e) |P=0.570 P=0.393N P=0.618 P=0.644N | |POLY 6 | (e) (e) (e) (e) |P=0.582 P=0.391N P=0.640 P=0.635N | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.566 P=0.295N P=0.710N P=0.652N | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.572 P=0.397N P=0.562 P=0.649N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lymph Node: Lumbar | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/6 (17%) 0/6 (0%) 0/5 (0%) 0/3 (0%) |4/19 (21%) 0/15 (0%) 1/4 (25%) 1/14 (7%) | |POLY-3 ADJUSTED (b)| 16.7% 0.0% 0.0% 0.0% |22.3% 0.0% 25.0% 7.7% | |TERMINAL (d) | 1/6 (17%) 0/3 (0%) 0/3 (0%) 0/0 (0%) |4/11 (36%) 0/11 (0%) 1/4 (25%) 1/10 (10%) | |FIRST INCIDENCE | 734 (T) --- --- --- |735 (T) --- 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=1.000N P=0.638N P=0.638N P=1.000N |P=0.419N P=0.053N P=0.579N P=0.189N | |POLY 3 | P=0.644N P=0.525N P=0.564N P=0.731N |P=0.460N P=0.082N P=0.703 P=0.278N | |POLY 1.5 | P=0.691N P=0.514N P=0.552N P=0.695N |P=0.459N P=0.082N P=0.693 P=0.278N | |POLY 6 | P=0.557N P=0.540N P=0.580N P=0.763N |P=0.460N P=0.080N P=0.718 P=0.274N | |LOGISTIC REGRESSION| P=1.000N (e) (e) (e) |P=0.419N (e) P=0.579N P=0.189N | |COCH-ARM / FISHERS | P=0.723N P=0.500N P=0.545N P=0.667N |P=0.456N P=0.084N P=0.654 P=0.278N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 41 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mammary Gland | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/2 (0%) 0/1 (0%) 1/3 (33%) 0/4 (0%) |3/94 (3%) 3/98 (3%) 5/99 (5%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 33.3% 0.0% |3.5% 3.4% 5.5% 2.2% | |TERMINAL (d) | 0/1 (0%) 0/1 (0%) 0/2 (0%) 0/3 (0%) |1/70 (1%) 2/74 (3%) 4/79 (5%) 1/74 (1%) | |FIRST INCIDENCE | --- --- 701 --- |702 491 513 721 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.804N (e) P=0.522 (e) |P=0.363N P=0.646N P=0.401 P=0.489N | |POLY 3 | P=0.633N (e) P=0.595 (e) |P=0.359N P=0.645N P=0.389 P=0.484N | |POLY 1.5 | P=0.627N (e) P=0.586 (e) |P=0.358N P=0.643N P=0.388 P=0.483N | |POLY 6 | P=0.637N (e) P=0.610 (e) |P=0.361N P=0.648N P=0.385 P=0.487N | |LOGISTIC REGRESSION| P=0.617N (e) P=0.445 (e) |P=0.348N P=0.636N P=0.388 P=0.482N | |COCH-ARM / FISHERS | P=0.629N (e) P=0.600 (e) |P=0.351N P=0.639N P=0.390 P=0.475N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mammary Gland: Duct | | Dilatation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/2 (0%) 0/1 (0%) 0/3 (0%) 1/4 (25%) |10/94 (11%) 15/98 (15%) 16/99 (16%) 17/99 (17%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 25.0% |11.5% 16.5% 17.1% 18.9% | |TERMINAL (d) | 0/1 (0%) 0/1 (0%) 0/2 (0%) 0/3 (0%) |6/70 (9%) 8/74 (11%) 10/79 (13%) 14/74 (19%) | |FIRST INCIDENCE | --- --- --- 568 |542 387 21 597 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.217 (e) (e) P=0.475 |P=0.219 P=0.230 P=0.210 P=0.138 | |POLY 3 | P=0.402 (e) (e) P=0.647 |P=0.207 P=0.229 P=0.192 P=0.122 | |POLY 1.5 | P=0.396 (e) (e) P=0.639 |P=0.212 P=0.228 P=0.189 P=0.125 | |POLY 6 | P=0.412 (e) (e) P=0.660 |P=0.200 P=0.228 P=0.191 P=0.118 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.236 P=0.232 P=0.189 P=0.127 | |COCH-ARM / FISHERS | P=0.371 (e) (e) P=0.667 |P=0.231 P=0.228 P=0.181 P=0.135 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 42 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mesentery: Fat | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/13 (8%) 3/16 (19%) 2/8 (25%) 0/10 (0%) |6/36 (17%) 4/27 (15%) 5/30 (17%) 4/30 (13%) | |POLY-3 ADJUSTED (b)| 8.1% 19.0% 26.8% 0.0% |17.3% 16.1% 16.8% 14.1% | |TERMINAL (d) | 1/10 (10%) 3/13 (23%) 2/7 (29%) 0/7 (0%) |4/24 (17%) 4/20 (20%) 5/29 (17%) 3/25 (12%) | |FIRST INCIDENCE | 734 (T) 734 (T) 734 (T) --- |701 735 (T) 735 (T) 715 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.259N P=0.398 P=0.370 P=0.571N |P=0.375N P=0.462N P=0.389N P=0.350N | |POLY 3 | P=0.243N P=0.395 P=0.319 P=0.557N |P=0.466N P=0.589N P=0.608N P=0.501N | |POLY 1.5 | P=0.237N P=0.388 P=0.322 P=0.555N |P=0.466N P=0.578N P=0.618N P=0.498N | |POLY 6 | P=0.252N P=0.404 P=0.319 P=0.561N |P=0.461N P=0.598N P=0.594N P=0.497N | |LOGISTIC REGRESSION| P=0.259N P=0.398 P=0.370 (e) |P=0.450N P=0.593N P=0.581N P=0.495N | |COCH-ARM / FISHERS | P=0.228N P=0.383 P=0.316 P=0.565N |P=0.461N P=0.563N P=0.627 P=0.491N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mesentery: Fat | | Necrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/13 (85%) 11/16 (69%) 4/8 (50%) 6/10 (60%) |22/36 (61%) 16/27 (59%) 23/30 (77%) 22/30 (73%) | |POLY-3 ADJUSTED (b)| 84.6% 69.3% 53.7% 64.2% |62.5% 61.8% 77.4% 73.5% | |TERMINAL (d) | 8/10 (80%) 10/13 (77%) 4/7 (57%) 5/7 (71%) |17/24 (71%) 13/20 (65%) 23/29 (79%) 18/25 (72%) | |FIRST INCIDENCE | 582 722 734 (T) 705 |603 496 735 (T) 474 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.412N P=0.334N P=0.063N P=0.304N |P=0.452 P=0.291N P=0.316N P=0.524N | |POLY 3 | P=0.368N P=0.304N P=0.154N P=0.270N |P=0.231 P=0.586N P=0.149 P=0.246 | |POLY 1.5 | P=0.334N P=0.298N P=0.132N P=0.236N |P=0.211 P=0.571N P=0.144 P=0.232 | |POLY 6 | P=0.415N P=0.315N P=0.185N P=0.322N |P=0.262 P=0.596N P=0.159 P=0.270 | |LOGISTIC REGRESSION| P=0.361N P=0.314N P=0.120N P=0.212N |P=0.182 P=0.585N P=0.200 P=0.227 | |COCH-ARM / FISHERS | P=0.292N P=0.292N P=0.115N P=0.197N |P=0.186 P=0.543N P=0.139 P=0.216 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 43 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Nose | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 2/99 (2%) 3/100 (3%) 2/97 (2%) |0/99 (0%) 0/100 (0%) 0/99 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 1.1% 2.3% 3.2% 2.4% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 1/76 (1%) 2/72 (3%) 3/84 (4%) 2/61 (3%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | 734 (T) 734 (T) 734 (T) 734 (T) |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.472 P=0.481 P=0.343 P=0.424 |(e) (e) (e) (e) | |POLY 3 | P=0.529 P=0.485 P=0.311 P=0.468 |(e) (e) (e) (e) | |POLY 1.5 | P=0.541 P=0.491 P=0.311 P=0.478 |(e) (e) (e) (e) | |POLY 6 | P=0.514 P=0.479 P=0.313 P=0.457 |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.472 P=0.481 P=0.343 P=0.424 |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.559 P=0.500 P=0.314 P=0.492 |(e) (e) (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Ovary | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |0/79 (0%) 2/91 (2%) 3/95 (3%) 0/94 (0%) | |POLY-3 ADJUSTED (b)| |0.0% 2.4% 3.4% 0.0% | |TERMINAL (d) | |0/65 (0%) 1/70 (1%) 3/78 (4%) 0/72 (0%) | |FIRST INCIDENCE | |--- 713 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.281N P=0.251 P=0.157 (e) | |POLY 3 | |P=0.279N P=0.263 P=0.153 (e) | |POLY 1.5 | |P=0.276N P=0.265 P=0.154 (e) | |POLY 6 | |P=0.280N P=0.261 P=0.150 (e) | |LOGISTIC REGRESSION| |P=0.274N P=0.263 P=0.157 (e) | |COCH-ARM / FISHERS | |P=0.268N P=0.285 P=0.160 (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 44 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Ovary | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |4/79 (5%) 3/91 (3%) 3/95 (3%) 5/94 (5%) | |POLY-3 ADJUSTED (b)| |5.4% 3.6% 3.4% 5.9% | |TERMINAL (d) | |3/65 (5%) 1/70 (1%) 1/78 (1%) 3/72 (4%) | |FIRST INCIDENCE | |703 505 659 690 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.343 P=0.476N P=0.444N P=0.542 | |POLY 3 | |P=0.367 P=0.436N P=0.409N P=0.584 | |POLY 1.5 | |P=0.369 P=0.433N P=0.407N P=0.588 | |POLY 6 | |P=0.366 P=0.439N P=0.414N P=0.580 | |LOGISTIC REGRESSION| |P=0.383 P=0.406N P=0.405N P=0.585 | |COCH-ARM / FISHERS | |P=0.381 P=0.422N P=0.399N P=0.608 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Ovary | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |22/79 (28%) 23/91 (25%) 30/95 (32%) 33/94 (35%) | |POLY-3 ADJUSTED (b)| |29.4% 27.5% 34.1% 38.7% | |TERMINAL (d) | |19/65 (29%) 21/70 (30%) 28/78 (36%) 30/72 (42%) | |FIRST INCIDENCE | |542 491 692 687 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.062 P=0.532N P=0.330 P=0.113 | |POLY 3 | |P=0.074 P=0.466N P=0.318 P=0.140 | |POLY 1.5 | |P=0.079 P=0.451N P=0.332 P=0.153 | |POLY 6 | |P=0.072 P=0.485N P=0.295 P=0.130 | |LOGISTIC REGRESSION| |P=0.077 P=0.464N P=0.307 P=0.141 | |COCH-ARM / FISHERS | |P=0.102 P=0.418N P=0.357 P=0.196 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 45 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Ovary | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |0/79 (0%) 0/91 (0%) 2/95 (2%) 0/94 (0%) | |POLY-3 ADJUSTED (b)| |0.0% 0.0% 2.3% 0.0% | |TERMINAL (d) | |0/65 (0%) 0/70 (0%) 2/78 (3%) 0/72 (0%) | |FIRST INCIDENCE | |--- --- 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.625N (e) P=0.280 (e) | |POLY 3 | |P=0.621N (e) P=0.276 (e) | |POLY 1.5 | |P=0.620N (e) P=0.278 (e) | |POLY 6 | |P=0.622N (e) P=0.273 (e) | |LOGISTIC REGRESSION| |(e) (e) P=0.280 (e) | |COCH-ARM / FISHERS | |P=0.614N (e) P=0.297 (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pancreas | | Infiltration Cellular Focal Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 0/99 (0%) 1/98 (1%) 1/95 (1%) |7/87 (8%) 12/94 (13%) 7/96 (7%) 10/94 (11%) | |POLY-3 ADJUSTED (b)| 1.1% 0.0% 1.1% 1.2% |8.5% 13.9% 7.9% 11.5% | |TERMINAL (d) | 1/76 (1%) 0/72 (0%) 1/84 (1%) 1/62 (2%) |7/70 (10%) 11/74 (15%) 7/79 (9%) 10/74 (14%) | |FIRST INCIDENCE | 734 (T) --- 734 (T) 734 (T) |735 (T) 729 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.503 P=0.511N P=0.739N P=0.715 |P=0.479 P=0.198 P=0.517N P=0.347 | |POLY 3 | P=0.535 P=0.508N P=0.760 P=0.738 |P=0.494 P=0.195 P=0.549N P=0.355 | |POLY 1.5 | P=0.539 P=0.505N P=0.759 P=0.743 |P=0.494 P=0.200 P=0.544N P=0.357 | |POLY 6 | P=0.530 P=0.512N P=0.758N P=0.731 |P=0.494 P=0.191 P=0.558N P=0.351 | |LOGISTIC REGRESSION| P=0.503 (e) P=0.739N P=0.715 |P=0.479 P=0.196 P=0.517N P=0.347 | |COCH-ARM / FISHERS | P=0.546 P=0.500N P=0.749 P=0.741 |P=0.496 P=0.215 P=0.533N P=0.367 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 46 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pancreas | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 4/99 (4%) 2/98 (2%) 0/95 (0%) |5/87 (6%) 0/94 (0%) 1/96 (1%) 3/94 (3%) | |POLY-3 ADJUSTED (b)| 1.1% 4.5% 2.2% 0.0% |6.1% 0.0% 1.1% 3.4% | |TERMINAL (d) | 0/76 (0%) 4/72 (6%) 2/84 (2%) 0/62 (0%) |3/70 (4%) 0/74 (0%) 0/79 (0%) 2/74 (3%) | |FIRST INCIDENCE | 717 734 (T) 734 (T) --- |667 --- 521 715 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.145N P=0.169 P=0.533 P=0.530N |P=0.475 P=0.033N* P=0.095N P=0.337N | |POLY 3 | P=0.135N P=0.170 P=0.500 P=0.520N |P=0.491 P=0.029N* P=0.087N P=0.327N | |POLY 1.5 | P=0.129N P=0.175 P=0.498 P=0.515N |P=0.489 P=0.029N* P=0.086N P=0.324N | |POLY 6 | P=0.142N P=0.164 P=0.503 P=0.526N |P=0.494 P=0.030N* P=0.089N P=0.330N | |LOGISTIC REGRESSION| P=0.136N P=0.162 P=0.505 P=0.519N |P=0.484 P=0.030N* P=0.078N P=0.323N | |COCH-ARM / FISHERS | P=0.122N P=0.184 P=0.496 P=0.510N |P=0.484 P=0.024N* P=0.084N P=0.318N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pancreas | | Lipomatosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 11/99 (11%) 14/98 (14%) 1/95 (1%) |21/87 (24%) 16/94 (17%) 23/96 (24%) 29/94 (31%) | |POLY-3 ADJUSTED (b)| 1.1% 12.5% 15.2% 1.2% |25.1% 18.4% 25.4% 32.8% | |TERMINAL (d) | 0/76 (0%) 10/72 (14%) 13/84 (16%) 0/62 (0%) |16/70 (23%) 14/74 (19%) 18/79 (23%) 25/74 (34%) | |FIRST INCIDENCE | 717 703 640 568 |334 505 472 474 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.057N P=0.003 ** P<0.001 ** P=0.734 |P=0.034 * P=0.192N P=0.555N P=0.175 | |POLY 3 | P=0.041N* P=0.002 ** P<0.001 ** P=0.739 |P=0.035 * P=0.192N P=0.551 P=0.169 | |POLY 1.5 | P=0.037N* P=0.003 ** P<0.001 ** P=0.744 |P=0.036 * P=0.182N P=0.559 P=0.177 | |POLY 6 | P=0.046N* P=0.002 ** P<0.001 ** P=0.733 |P=0.034 * P=0.202N P=0.536 P=0.160 | |LOGISTIC REGRESSION| P=0.042N* P=0.002 ** P<0.001 ** P=0.730N |P=0.038 * P=0.158N P=0.548N P=0.196 | |COCH-ARM / FISHERS | P=0.035N* P=0.002 ** P<0.001 ** P=0.741 |P=0.038 * P=0.158N P=0.557N P=0.200 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 47 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pancreas | | Vacuolization Cytoplasmic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 16/99 (16%) 31/99 (31%) 28/98 (29%) 5/95 (5%) |12/87 (14%) 21/94 (22%) 18/96 (19%) 16/94 (17%) | |POLY-3 ADJUSTED (b)| 17.4% 35.2% 30.4% 6.0% |14.6% 23.8% 20.3% 18.2% | |TERMINAL (d) | 15/76 (20%) 31/72 (43%) 27/84 (32%) 4/62 (7%) |12/70 (17%) 18/74 (24%) 18/79 (23%) 15/74 (20%) | |FIRST INCIDENCE | 715 734 (T) 654 577 |735 (T) 387 735 (T) 497 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P<0.001N** P=0.004 ** P=0.061 P=0.032N* |P=0.470N P=0.084 P=0.258 P=0.319 | |POLY 3 | P<0.001N** P=0.005 ** P=0.028 * P=0.017N* |P=0.447N P=0.093 P=0.222 P=0.339 | |POLY 1.5 | P<0.001N** P=0.006 ** P=0.027 * P=0.015N* |P=0.447N P=0.094 P=0.229 P=0.340 | |POLY 6 | P<0.001N** P=0.003 ** P=0.030 * P=0.020N* |P=0.446N P=0.093 P=0.211 P=0.338 | |LOGISTIC REGRESSION| P<0.001N** P=0.004 ** P=0.036 * P=0.022N* |P=0.443N P=0.095 P=0.258 P=0.331 | |COCH-ARM / FISHERS | P<0.001N** P=0.009 ** P=0.027 * P=0.012N* |P=0.443N P=0.097 P=0.241 P=0.348 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pancreas: Acinus | | Cytoplasmic Alteration | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/99 (1%) 3/98 (3%) 0/95 (0%) |1/87 (1%) 3/94 (3%) 4/96 (4%) 2/94 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 1.1% 3.2% 0.0% |1.2% 3.5% 4.5% 2.3% | |TERMINAL (d) | 0/76 (0%) 1/72 (1%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 1/74 (1%) 2/79 (3%) 1/74 (1%) | |FIRST INCIDENCE | --- 734 (T) 556 --- |735 (T) 496 578 687 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.443N P=0.489 P=0.129 (e) |P=0.559N P=0.321 P=0.211 P=0.513 | |POLY 3 | P=0.435N P=0.492 P=0.123 (e) |P=0.549N P=0.328 P=0.211 P=0.523 | |POLY 1.5 | P=0.427N P=0.495 P=0.122 (e) |P=0.549N P=0.329 P=0.211 P=0.523 | |POLY 6 | P=0.444N P=0.488 P=0.126 (e) |P=0.550N P=0.326 P=0.209 P=0.522 | |LOGISTIC REGRESSION| P=0.387N P=0.489 P=0.115 (e) |P=0.544N P=0.357 P=0.228 P=0.524 | |COCH-ARM / FISHERS | P=0.416N P=0.500 P=0.121 (e) |P=0.546N P=0.340 P=0.216 P=0.529 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 48 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pancreas: Acinus | | Hypertrophy Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/99 (1%) 1/98 (1%) 0/95 (0%) |1/87 (1%) 0/94 (0%) 2/96 (2%) 0/94 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.1% 1.1% 0.0% |1.2% 0.0% 2.2% 0.0% | |TERMINAL (d) | 0/76 (0%) 1/72 (1%) 1/84 (1%) 0/62 (0%) |1/70 (1%) 0/74 (0%) 1/79 (1%) 0/74 (0%) | |FIRST INCIDENCE | --- 734 (T) 734 (T) --- |735 (T) --- 578 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.547N P=0.489 P=0.520 (e) |P=0.442N P=0.489N P=0.532 P=0.489N | |POLY 3 | P=0.525N P=0.492 P=0.500 (e) |P=0.432N P=0.490N P=0.530 P=0.487N | |POLY 1.5 | P=0.519N P=0.495 P=0.499 (e) |P=0.433N P=0.489N P=0.531 P=0.487N | |POLY 6 | P=0.531N P=0.488 P=0.502 (e) |P=0.432N P=0.491N P=0.527 P=0.488N | |LOGISTIC REGRESSION| (e) P=0.489 P=0.520 (e) |P=0.434N (e) P=0.548 (e) | |COCH-ARM / FISHERS | P=0.510N P=0.500 P=0.497 (e) |P=0.435N P=0.481N P=0.537 P=0.481N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pancreas: Duct | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 1/99 (1%) 1/98 (1%) 2/95 (2%) |1/87 (1%) 1/94 (1%) 3/96 (3%) 1/94 (1%) | |POLY-3 ADJUSTED (b)| 2.2% 1.1% 1.1% 2.4% |1.2% 1.2% 3.4% 1.1% | |TERMINAL (d) | 2/76 (3%) 1/72 (1%) 1/84 (1%) 1/62 (2%) |1/70 (1%) 1/74 (1%) 2/79 (3%) 1/74 (1%) | |FIRST INCIDENCE | 734 (T) 734 (T) 734 (T) 525 |735 (T) 735 (T) 654 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.430 P=0.519N P=0.465N P=0.631 |P=0.575N P=0.749N P=0.339 P=0.749N | |POLY 3 | P=0.472 P=0.515N P=0.500N P=0.659 |P=0.566N P=0.749N P=0.337 P=0.746N | |POLY 1.5 | P=0.477 P=0.509N P=0.502N P=0.667 |P=0.567N P=0.748N P=0.339 P=0.746N | |POLY 6 | P=0.465 P=0.521N P=0.496N P=0.650 |P=0.566N P=0.751N P=0.333 P=0.747N | |LOGISTIC REGRESSION| P=0.490 P=0.519N P=0.465N P=0.683N |P=0.566N P=0.749N P=0.340 P=0.749N | |COCH-ARM / FISHERS | P=0.484 P=0.500N P=0.504N P=0.674 |P=0.567N P=0.732N P=0.348 P=0.732N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 49 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Parathyroid Gland | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/66 (2%) 2/55 (4%) 2/72 (3%) 0/65 (0%) |11/63 (17%) 8/53 (15%) 7/53 (13%) 6/53 (11%) | |POLY-3 ADJUSTED (b)| 1.6% 4.2% 3.0% 0.0% |18.3% 16.3% 14.2% 12.1% | |TERMINAL (d) | 1/48 (2%) 2/37 (5%) 0/61 (0%) 0/40 (0%) |10/48 (21%) 7/40 (18%) 5/41 (12%) 4/42 (10%) | |FIRST INCIDENCE | 734 (T) 734 (T) 585 --- |733 698 472 684 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.240N P=0.410 P=0.526 P=0.536N |P=0.227N P=0.453N P=0.315N P=0.209N | |POLY 3 | P=0.230N P=0.416 P=0.536 P=0.520N |P=0.262N P=0.491N P=0.376N P=0.265N | |POLY 1.5 | P=0.222N P=0.424 P=0.533 P=0.513N |P=0.264N P=0.481N P=0.373N P=0.262N | |POLY 6 | P=0.240N P=0.407 P=0.543 P=0.526N |P=0.260N P=0.503N P=0.382N P=0.267N | |LOGISTIC REGRESSION| P=0.192N P=0.410 P=0.540 (e) |P=0.263N P=0.523N P=0.356N P=0.276N | |COCH-ARM / FISHERS | P=0.209N P=0.431 P=0.533 P=0.504N |P=0.261N P=0.466N P=0.357N P=0.254N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Parathyroid Gland | | Inflammation Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/66 (0%) 0/55 (0%) 0/72 (0%) 0/65 (0%) |0/63 (0%) 0/53 (0%) 2/53 (4%) 0/53 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 4.2% 0.0% | |TERMINAL (d) | 0/48 (0%) 0/37 (0%) 0/61 (0%) 0/40 (0%) |0/48 (0%) 0/40 (0%) 2/41 (5%) 0/42 (0%) | |FIRST INCIDENCE | --- --- --- --- |--- --- 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.643N (e) P=0.205 (e) | |POLY 3 | (e) (e) (e) (e) |P=0.658N (e) P=0.190 (e) | |POLY 1.5 | (e) (e) (e) (e) |P=0.657N (e) P=0.193 (e) | |POLY 6 | (e) (e) (e) (e) |P=0.659N (e) P=0.187 (e) | |LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) P=0.205 (e) | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.653N (e) P=0.207 (e) | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 50 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/83 (11%) 7/84 (8%) 6/82 (7%) 4/84 (5%) |0/83 (0%) 2/92 (2%) 3/87 (3%) 1/89 (1%) | |POLY-3 ADJUSTED (b)| 11.5% 9.2% 7.7% 5.4% |0.0% 2.4% 3.6% 1.2% | |TERMINAL (d) | 7/66 (11%) 6/64 (9%) 6/72 (8%) 3/57 (5%) |0/67 (0%) 2/71 (3%) 3/76 (4%) 0/71 (0%) | |FIRST INCIDENCE | 617 542 734 (T) 630 |--- 735 (T) 735 (T) 684 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.206N P=0.426N P=0.242N P=0.191N |P=0.573N P=0.252 P=0.146 P=0.502 | |POLY 3 | P=0.158N P=0.418N P=0.300N P=0.145N |P=0.576N P=0.258 P=0.135 P=0.511 | |POLY 1.5 | P=0.148N P=0.406N P=0.302N P=0.134N |P=0.577N P=0.259 P=0.133 P=0.511 | |POLY 6 | P=0.169N P=0.432N P=0.296N P=0.158N |P=0.575N P=0.257 P=0.136 P=0.512 | |LOGISTIC REGRESSION| P=0.149N P=0.401N P=0.295N P=0.137N |P=0.577N P=0.252 P=0.146 P=0.520 | |COCH-ARM / FISHERS | P=0.134N P=0.387N P=0.303N P=0.119N |P=0.572N P=0.275 P=0.132 P=0.517 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/83 (1%) 2/84 (2%) 1/82 (1%) 3/84 (4%) |37/83 (45%) 50/92 (54%) 33/87 (38%) 35/89 (39%) | |POLY-3 ADJUSTED (b)| 1.3% 2.6% 1.3% 4.0% |47.8% 56.6% 39.1% 41.2% | |TERMINAL (d) | 1/66 (2%) 2/64 (3%) 0/72 (0%) 2/57 (4%) |35/67 (52%) 41/71 (58%) 28/76 (37%) 26/71 (37%) | |FIRST INCIDENCE | 734 (T) 734 (T) 590 568 |691 387 472 474 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.210 P=0.489 P=0.752N P=0.262 |P=0.117N P=0.073 P=0.142N P=0.341N | |POLY 3 | P=0.245 P=0.490 P=0.760N P=0.290 |P=0.086N P=0.161 P=0.168N P=0.245N | |POLY 1.5 | P=0.252 P=0.495 P=0.759 P=0.299 |P=0.096N P=0.143 P=0.189N P=0.273N | |POLY 6 | P=0.237 P=0.484 P=0.757N P=0.281 |P=0.075N P=0.180 P=0.150N P=0.215N | |LOGISTIC REGRESSION| P=0.283 P=0.489 P=0.756 P=0.327 |P=0.105N P=0.111 P=0.188N P=0.315N | |COCH-ARM / FISHERS | P=0.262 P=0.505 P=0.748 P=0.315 |P=0.099N P=0.127 P=0.234N P=0.294N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 51 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Hypertrophy Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/83 (0%) 0/84 (0%) 0/82 (0%) 0/84 (0%) |0/83 (0%) 0/92 (0%) 3/87 (3%) 1/89 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 3.6% 1.2% | |TERMINAL (d) | 0/66 (0%) 0/64 (0%) 0/72 (0%) 0/57 (0%) |0/67 (0%) 0/71 (0%) 2/76 (3%) 1/71 (1%) | |FIRST INCIDENCE | --- --- --- --- |--- --- 513 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.503 (e) P=0.139 P=0.512 | |POLY 3 | (e) (e) (e) (e) |P=0.507 (e) P=0.136 P=0.511 | |POLY 1.5 | (e) (e) (e) (e) |P=0.505 (e) P=0.134 P=0.511 | |POLY 6 | (e) (e) (e) (e) |P=0.508 (e) P=0.138 P=0.511 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.521 (e) P=0.089 P=0.512 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.507 (e) P=0.132 P=0.517 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Preputial Gland | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 25/98 (26%) 56/98 (57%) 49/100 (49%) 37/95 (39%) | | |POLY-3 ADJUSTED (b)| 27.0% 62.1% 50.6% 42.3% | | |TERMINAL (d) | 15/75 (20%) 44/72 (61%) 38/84 (45%) 20/61 (33%) | | |FIRST INCIDENCE | 624 589 556 510 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.399 P<0.001 ** P=0.004 ** P=0.012 * | | |POLY 3 | P=0.365N P<0.001 ** P<0.001 ** P=0.022 * | | |POLY 1.5 | P=0.344N P<0.001 ** P<0.001 ** P=0.025 * | | |POLY 6 | P=0.388N P<0.001 ** P<0.001 ** P=0.019 * | | |LOGISTIC REGRESSION| P=0.366N P<0.001 ** P<0.001 ** P=0.029 * | | |COCH-ARM / FISHERS | P=0.318N P<0.001 ** P<0.001 ** P=0.032 * | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 52 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Preputial Gland | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 84/98 (86%) 88/98 (90%) 93/100 (93%) 76/95 (80%) | | |POLY-3 ADJUSTED (b)| 87.6% 93.6% 94.4% 82.7% | | |TERMINAL (d) | 65/75 (87%) 69/72 (96%) 80/84 (95%) 48/61 (79%) | | |FIRST INCIDENCE | 386 461 449 448 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.320 P=0.167 P=0.529 P=0.253 | | |POLY 3 | P=0.014N* P=0.104 P=0.072 P=0.226N | | |POLY 1.5 | P=0.017N* P=0.153 P=0.069 P=0.213N | | |POLY 6 | P=0.013N* P=0.069 P=0.083 P=0.239N | | |LOGISTIC REGRESSION| P=0.047N* P=0.142 P=0.074 P=0.253N | | |COCH-ARM / FISHERS | P=0.025N* P=0.257 P=0.075 P=0.194N | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Preputial Gland | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 46/98 (47%) 37/98 (38%) 56/100 (56%) 53/95 (56%) | | |POLY-3 ADJUSTED (b)| 49.8% 41.9% 57.9% 60.8% | | |TERMINAL (d) | 39/75 (52%) 31/72 (43%) 47/84 (56%) 36/61 (59%) | | |FIRST INCIDENCE | 617 629 549 510 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.002 ** P=0.195N P=0.292 P=0.022 * | | |POLY 3 | P=0.023 * P=0.179N P=0.162 P=0.087 | | |POLY 1.5 | P=0.026 * P=0.153N P=0.146 P=0.105 | | |POLY 6 | P=0.021 * P=0.214N P=0.188 P=0.072 | | |LOGISTIC REGRESSION| P=0.015 * P=0.192N P=0.130 P=0.069 | | |COCH-ARM / FISHERS | P=0.035 * P=0.124N P=0.129 P=0.139 | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 53 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Prostate | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 4/92 (4%) 4/94 (4%) 2/94 (2%) | | |POLY-3 ADJUSTED (b)| 2.2% 4.8% 4.5% 2.5% | | |TERMINAL (d) | 1/76 (1%) 4/69 (6%) 4/80 (5%) 2/59 (3%) | | |FIRST INCIDENCE | 684 734 (T) 734 (T) 734 (T) | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.504N P=0.297 P=0.360 P=0.610 | | |POLY 3 | P=0.434N P=0.294 P=0.323 P=0.649 | | |POLY 1.5 | P=0.418N P=0.301 P=0.322 P=0.661 | | |POLY 6 | P=0.455N P=0.286 P=0.325 P=0.634 | | |LOGISTIC REGRESSION| P=0.461N P=0.288 P=0.325 P=0.643 | | |COCH-ARM / FISHERS | P=0.394N P=0.312 P=0.322 P=0.674 | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Prostate: Epithelium | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 49/98 (50%) 52/92 (57%) 56/94 (60%) 47/94 (50%) | | |POLY-3 ADJUSTED (b)| 52.9% 62.3% 61.1% 54.4% | | |TERMINAL (d) | 47/76 (62%) 48/69 (70%) 49/80 (61%) 33/59 (56%) | | |FIRST INCIDENCE | 386 589 430 448 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.190 P=0.142 P=0.302 P=0.130 | | |POLY 3 | P=0.331N P=0.128 P=0.160 P=0.476 | | |POLY 1.5 | P=0.312N P=0.161 P=0.139 P=0.506 | | |POLY 6 | P=0.355N P=0.101 P=0.199 P=0.447 | | |LOGISTIC REGRESSION| P=0.424N P=0.115 P=0.120 P=0.452 | | |COCH-ARM / FISHERS | P=0.284N P=0.225 P=0.118 P=0.557N | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 54 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Salivary Glands | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 66/99 (67%) 65/99 (66%) 72/98 (73%) 61/96 (64%) |74/94 (79%) 83/98 (85%) 77/97 (79%) 75/98 (77%) | |POLY-3 ADJUSTED (b)| 70.1% 71.3% 75.9% 67.8% |80.9% 87.7% 81.2% 78.4% | |TERMINAL (d) | 58/76 (76%) 56/72 (78%) 66/84 (79%) 44/62 (71%) |60/70 (86%) 67/74 (91%) 63/79 (80%) 57/73 (78%) | |FIRST INCIDENCE | 520 400 449 466 |334 387 472 183 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.175 P=0.406 P=0.543N P=0.212 |P=0.327N P=0.255 P=0.313N P=0.474N | |POLY 3 | P=0.292N P=0.494 P=0.225 P=0.428N |P=0.142N P=0.133 P=0.551 P=0.404N | |POLY 1.5 | P=0.291N P=0.550 P=0.207 P=0.406N |P=0.159N P=0.144 P=0.529 P=0.421N | |POLY 6 | P=0.297N P=0.428 P=0.256 P=0.457N |P=0.126N P=0.122 P=0.573 P=0.387N | |LOGISTIC REGRESSION| P=0.447N P=0.420 P=0.183 P=0.537N |P=0.217N P=0.158 P=0.528 P=0.450N | |COCH-ARM / FISHERS | P=0.294N P=0.500N P=0.188 P=0.379N |P=0.185N P=0.188 P=0.526 P=0.425N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Seminal Vesicle | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/97 (0%) 1/98 (1%) 3/98 (3%) | | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 1.1% 3.5% | | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 1/62 (2%) | | |FIRST INCIDENCE | --- --- 701 483 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.019 * (e) P=0.509 P=0.104 | | |POLY 3 | P=0.023 * (e) P=0.499 P=0.109 | | |POLY 1.5 | P=0.024 * (e) P=0.499 P=0.113 | | |POLY 6 | P=0.022 * (e) P=0.501 P=0.104 | | |LOGISTIC REGRESSION| P=0.040 * (e) P=0.498 P=0.166 | | |COCH-ARM / FISHERS | P=0.026 * (e) P=0.497 P=0.121 | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 55 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Seminal Vesicle | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 80/99 (81%) 63/97 (65%) 59/98 (60%) 68/98 (69%) | | |POLY-3 ADJUSTED (b)| 82.9% 67.8% 62.7% 74.4% | | |TERMINAL (d) | 65/76 (86%) 49/72 (68%) 53/84 (63%) 50/62 (81%) | | |FIRST INCIDENCE | 386 474 527 458 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.071 P=0.051N P<0.001N** P=0.474 | | |POLY 3 | P=0.505 P=0.010N* P<0.001N** P=0.099N | | |POLY 1.5 | P=0.516N P=0.010N* P<0.001N** P=0.073N | | |POLY 6 | P=0.426 P=0.010N* P<0.001N** P=0.134N | | |LOGISTIC REGRESSION| P=0.533N P=0.013N* P<0.001N** P=0.099N | | |COCH-ARM / FISHERS | P=0.415N P=0.009N** P<0.001N** P=0.045N* | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Seminal Vesicle | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 1/97 (1%) 2/98 (2%) 0/98 (0%) | | |POLY-3 ADJUSTED (b)| 2.2% 1.2% 2.2% 0.0% | | |TERMINAL (d) | 2/76 (3%) 0/72 (0%) 2/84 (2%) 0/62 (0%) | | |FIRST INCIDENCE | 734 (T) 719 734 (T) --- | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.264N P=0.514N P=0.657N P=0.285N | | |POLY 3 | P=0.238N P=0.520N P=0.691 P=0.258N | | |POLY 1.5 | P=0.231N P=0.515N P=0.690 P=0.251N | | |POLY 6 | P=0.246N P=0.525N P=0.691N P=0.266N | | |LOGISTIC REGRESSION| P=0.250N P=0.527N P=0.657N (e) | | |COCH-ARM / FISHERS | P=0.222N P=0.508N P=0.686 P=0.251N | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 56 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Ulcer Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/99 (1%) 0/100 (0%) 1/100 (1%) |2/99 (2%) 0/100 (0%) 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.1% 0.0% 1.2% |2.2% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | --- 725 --- 729 |691 --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.456 P=0.489 (e) P=0.460 |P=0.366N P=0.237N P=0.232N P=0.239N | |POLY 3 | P=0.482 P=0.492 (e) P=0.486 |P=0.364N P=0.238N P=0.236N P=0.239N | |POLY 1.5 | P=0.490 P=0.495 (e) P=0.492 |P=0.364N P=0.237N P=0.237N P=0.239N | |POLY 6 | P=0.473 P=0.488 (e) P=0.478 |P=0.363N P=0.238N P=0.236N P=0.239N | |LOGISTIC REGRESSION| P=0.477 P=0.488 (e) P=0.472 |P=0.365N P=0.237N P=0.237N P=0.238N | |COCH-ARM / FISHERS | P=0.501 P=0.500 (e) P=0.503 |P=0.364N P=0.246N P=0.246N P=0.246N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Spleen | | Hematopoietic Cell Proliferation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 37/99 (37%) 43/98 (44%) 52/98 (53%) 36/93 (39%) |74/91 (81%) 77/93 (83%) 87/95 (92%) 83/93 (89%) | |POLY-3 ADJUSTED (b)| 39.2% 46.4% 54.1% 41.7% |84.2% 85.5% 94.4% 90.8% | |TERMINAL (d) | 29/76 (38%) 29/72 (40%) 43/84 (51%) 24/62 (39%) |63/70 (90%) 67/74 (91%) 77/79 (98%) 68/74 (92%) | |FIRST INCIDENCE | 386 461 430 448 |397 64 472 85 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.480 P=0.172 P=0.087 P=0.269 |P=0.181 P=0.525N P=0.260 P=0.245 | |POLY 3 | P=0.385N P=0.196 P=0.026 * P=0.420 |P=0.147 P=0.486 P=0.017 * P=0.123 | |POLY 1.5 | P=0.354N P=0.202 P=0.022 * P=0.445 |P=0.130 P=0.489 P=0.019 * P=0.111 | |POLY 6 | P=0.422N P=0.195 P=0.032 * P=0.395 |P=0.174 P=0.480 P=0.013 * P=0.139 | |LOGISTIC REGRESSION| P=0.285N P=0.228 P=0.018 * P=0.505 |P=0.113 P=0.413 P=0.021 * P=0.084 | |COCH-ARM / FISHERS | P=0.311N P=0.216 P=0.019 * P=0.483 |P=0.110 P=0.472 P=0.033 * P=0.095 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 57 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Spleen | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/98 (1%) 0/98 (0%) 0/93 (0%) |17/91 (19%) 6/93 (6%) 8/95 (8%) 12/93 (13%) | |POLY-3 ADJUSTED (b)| 0.0% 1.1% 0.0% 0.0% |20.0% 7.0% 9.0% 13.8% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |15/70 (21%) 3/74 (4%) 6/79 (8%) 11/74 (15%) | |FIRST INCIDENCE | --- 722 --- --- |696 547 645 730 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.632N P=0.492 (e) (e) |P=0.469 P=0.011N* P=0.024N* P=0.167N | |POLY 3 | P=0.618N P=0.491 (e) (e) |P=0.471 P=0.011N* P=0.032N* P=0.189N | |POLY 1.5 | P=0.614N P=0.493 (e) (e) |P=0.468 P=0.011N* P=0.033N* P=0.192N | |POLY 6 | P=0.622N P=0.488 (e) (e) |P=0.471 P=0.010N* P=0.032N* P=0.186N | |LOGISTIC REGRESSION| P=0.618N P=0.489 (e) (e) |P=0.474 P=0.012N* P=0.035N* P=0.172N | |COCH-ARM / FISHERS | P=0.608N P=0.497 (e) (e) |P=0.462 P=0.010N* P=0.033N* P=0.191N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Spleen: Lymphoid Follicle | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/99 (11%) 12/98 (12%) 8/98 (8%) 14/93 (15%) |6/91 (7%) 4/93 (4%) 7/95 (7%) 3/93 (3%) | |POLY-3 ADJUSTED (b)| 11.6% 13.2% 8.5% 16.5% |6.9% 4.6% 7.8% 3.4% | |TERMINAL (d) | 1/76 (1%) 1/72 (1%) 1/84 (1%) 2/62 (3%) |1/70 (1%) 0/74 (0%) 1/79 (1%) 0/74 (0%) | |FIRST INCIDENCE | 520 474 549 466 |552 491 521 687 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.172 P=0.443 P=0.303N P=0.234 |P=0.259N P=0.374N P=0.515 P=0.253N | |POLY 3 | P=0.175 P=0.455 P=0.317N P=0.235 |P=0.248N P=0.368N P=0.532 P=0.241N | |POLY 1.5 | P=0.185 P=0.469 P=0.320N P=0.251 |P=0.248N P=0.367N P=0.531 P=0.240N | |POLY 6 | P=0.165 P=0.440 P=0.311N P=0.220 |P=0.248N P=0.369N P=0.532 P=0.241N | |LOGISTIC REGRESSION| P=0.340 P=0.567N P=0.338N P=0.438 |P=0.248N P=0.286N P=0.578 P=0.221N | |COCH-ARM / FISHERS | P=0.202 P=0.490 P=0.324N P=0.275 |P=0.247N P=0.360N P=0.533 P=0.238N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 58 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Spleen: Lymphoid Follicle | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 21/99 (21%) 27/98 (28%) 17/98 (17%) 13/93 (14%) |31/91 (34%) 31/93 (33%) 32/95 (34%) 34/93 (37%) | |POLY-3 ADJUSTED (b)| 22.8% 30.8% 18.4% 16.0% |36.5% 35.5% 35.7% 39.0% | |TERMINAL (d) | 20/76 (26%) 27/72 (38%) 16/84 (19%) 13/62 (21%) |31/70 (44%) 29/74 (39%) 30/79 (38%) 32/74 (43%) | |FIRST INCIDENCE | 683 734 (T) 654 734 (T) |735 (T) 64 21 687 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.082N P=0.136 P=0.191N P=0.242N |P=0.359 P=0.456N P=0.392N P=0.486 | |POLY 3 | P=0.049N* P=0.146 P=0.288N P=0.174N |P=0.349 P=0.512N P=0.521N P=0.429 | |POLY 1.5 | P=0.043N* P=0.164 P=0.297N P=0.155N |P=0.342 P=0.514N P=0.523N P=0.420 | |POLY 6 | P=0.058N P=0.128 P=0.274N P=0.196N |P=0.360 P=0.504N P=0.525N P=0.441 | |LOGISTIC REGRESSION| P=0.064N P=0.128 P=0.262N P=0.220N |P=0.361 P=0.543N P=0.553N P=0.480 | |COCH-ARM / FISHERS | P=0.035N* P=0.192 P=0.306N P=0.131N |P=0.349 P=0.520N P=0.540N P=0.421 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Spleen: Red Pulp | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 4/98 (4%) 3/98 (3%) 4/93 (4%) |2/91 (2%) 3/93 (3%) 0/95 (0%) 0/93 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 4.5% 3.2% 4.9% |2.3% 3.5% 0.0% 0.0% | |TERMINAL (d) | 0/76 (0%) 3/72 (4%) 0/84 (0%) 1/62 (2%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | --- 618 556 577 |542 496 --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.193 P=0.059 P=0.123 P=0.048 * |P=0.118N P=0.501 P=0.234N P=0.239N | |POLY 3 | P=0.202 P=0.058 P=0.124 P=0.050 |P=0.113N P=0.504 P=0.233N P=0.235N | |POLY 1.5 | P=0.210 P=0.060 P=0.122 P=0.052 |P=0.113N P=0.504 P=0.232N P=0.235N | |POLY 6 | P=0.194 P=0.057 P=0.128 P=0.048 * |P=0.112N P=0.505 P=0.235N P=0.234N | |LOGISTIC REGRESSION| P=0.267 P=0.063 P=0.104 P=0.064 |P=0.112N P=0.570 P=0.200N P=0.208N | |COCH-ARM / FISHERS | P=0.224 P=0.059 P=0.121 P=0.053 |P=0.114N P=0.510 P=0.238N P=0.243N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 59 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Stomach, Forestomach | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/98 (0%) 0/97 (0%) 0/96 (0%) |0/91 (0%) 0/92 (0%) 3/93 (3%) 1/94 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 3.4% 1.2% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 1/79 (1%) 1/74 (1%) | |FIRST INCIDENCE | --- --- --- --- |--- --- 513 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.501 (e) P=0.130 P=0.511 | |POLY 3 | (e) (e) (e) (e) |P=0.509 (e) P=0.127 P=0.505 | |POLY 1.5 | (e) (e) (e) (e) |P=0.509 (e) P=0.126 P=0.505 | |POLY 6 | (e) (e) (e) (e) |P=0.509 (e) P=0.129 P=0.505 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.513 (e) P=0.136 P=0.511 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.509 (e) P=0.127 P=0.508 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Stomach, Forestomach: Epithelium | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/99 (9%) 10/98 (10%) 8/97 (8%) 7/96 (7%) |6/91 (7%) 11/92 (12%) 5/93 (5%) 10/94 (11%) | |POLY-3 ADJUSTED (b)| 9.8% 11.3% 8.7% 8.3% |7.0% 12.9% 5.7% 11.4% | |TERMINAL (d) | 8/76 (11%) 7/72 (10%) 7/84 (8%) 5/62 (8%) |4/70 (6%) 9/74 (12%) 4/79 (5%) 7/74 (10%) | |FIRST INCIDENCE | 715 618 701 568 |701 461 645 477 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.462N P=0.445 P=0.420N P=0.554N |P=0.337 P=0.182 P=0.443N P=0.247 | |POLY 3 | P=0.366N P=0.463 P=0.503N P=0.470N |P=0.346 P=0.156 P=0.483N P=0.234 | |POLY 1.5 | P=0.348N P=0.473 P=0.510N P=0.450N |P=0.346 P=0.156 P=0.485N P=0.234 | |POLY 6 | P=0.388N P=0.454 P=0.491N P=0.492N |P=0.346 P=0.156 P=0.481N P=0.234 | |LOGISTIC REGRESSION| P=0.366N P=0.454 P=0.477N P=0.487N |P=0.348 P=0.157 P=0.485N P=0.235 | |COCH-ARM / FISHERS | P=0.322N P=0.491 P=0.518N P=0.423N |P=0.349 P=0.160 P=0.485N P=0.237 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 60 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Stomach, Forestomach: Epithelium | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/98 (0%) 3/97 (3%) 0/96 (0%) |4/91 (4%) 5/92 (5%) 4/93 (4%) 5/94 (5%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 3.2% 0.0% |4.7% 5.8% 4.6% 5.8% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |4/70 (6%) 2/74 (3%) 3/79 (4%) 5/74 (7%) | |FIRST INCIDENCE | --- --- 556 --- |735 (T) 496 694 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.575N (e) P=0.123 (e) |P=0.507 P=0.526 P=0.585N P=0.534 | |POLY 3 | P=0.580N (e) P=0.124 (e) |P=0.511 P=0.505 P=0.626N P=0.514 | |POLY 1.5 | P=0.572N (e) P=0.121 (e) |P=0.513 P=0.504 P=0.628N P=0.515 | |POLY 6 | P=0.588N (e) P=0.128 (e) |P=0.509 P=0.509 P=0.624N P=0.514 | |LOGISTIC REGRESSION| P=0.479N (e) P=0.089 (e) |P=0.516 P=0.510 P=0.626N P=0.534 | |COCH-ARM / FISHERS | P=0.562N (e) P=0.119 (e) |P=0.518 P=0.507 P=0.628N P=0.520 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Stomach, Glandular | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/94 (0%) 0/93 (0%) 0/97 (0%) 0/87 (0%) |7/86 (8%) 8/90 (9%) 3/93 (3%) 0/93 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |8.6% 9.6% 3.4% 0.0% | |TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |7/70 (10%) 8/74 (11%) 3/79 (4%) 0/74 (0%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 735 (T) 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.004N** P=0.545 P=0.119N P=0.008N** | |POLY 3 | (e) (e) (e) (e) |P=0.004N** P=0.517 P=0.139N P=0.007N** | |POLY 1.5 | (e) (e) (e) (e) |P=0.004N** P=0.522 P=0.137N P=0.007N** | |POLY 6 | (e) (e) (e) (e) |P=0.004N** P=0.513 P=0.142N P=0.007N** | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.004N** P=0.545 P=0.119N (e) | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.004N** P=0.537 P=0.135N P=0.005N** | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 61 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Stomach, Glandular | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/94 (0%) 3/93 (3%) 1/97 (1%) 0/87 (0%) |1/86 (1%) 1/90 (1%) 1/93 (1%) 1/93 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 3.5% 1.1% 0.0% |1.2% 1.2% 1.1% 1.1% | |TERMINAL (d) | 0/76 (0%) 1/72 (1%) 1/84 (1%) 0/62 (0%) |0/70 (0%) 1/74 (1%) 1/79 (1%) 1/74 (1%) | |FIRST INCIDENCE | --- 629 734 (T) --- |725 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.264N P=0.115 P=0.520 (e) |P=0.683N P=0.753N P=0.743N P=0.751N | |POLY 3 | P=0.263N P=0.115 P=0.506 (e) |P=0.671N P=0.756N P=0.746N P=0.746N | |POLY 1.5 | P=0.257N P=0.117 P=0.506 (e) |P=0.671N P=0.754N P=0.745N P=0.745N | |POLY 6 | P=0.269N P=0.114 P=0.507 (e) |P=0.672N P=0.757N P=0.748N P=0.747N | |LOGISTIC REGRESSION| P=0.243N P=0.126 P=0.520 (e) |P=0.674N P=0.758N P=0.749N P=0.748N | |COCH-ARM / FISHERS | P=0.249N P=0.121 P=0.508 (e) |P=0.672N P=0.740N P=0.731N P=0.731N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Stomach, Glandular: Epithelium | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 8/94 (9%) 9/93 (10%) 8/97 (8%) 8/87 (9%) |14/86 (16%) 24/90 (27%) 20/93 (22%) 18/93 (19%) | |POLY-3 ADJUSTED (b)| 9.0% 10.5% 8.7% 10.1% |16.7% 28.2% 22.1% 20.2% | |TERMINAL (d) | 7/76 (9%) 7/72 (10%) 7/84 (8%) 5/62 (8%) |8/70 (11%) 19/74 (26%) 14/79 (18%) 11/74 (15%) | |FIRST INCIDENCE | 715 618 701 545 |334 461 21 467 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.455 P=0.449 P=0.526N P=0.453 |P=0.438N P=0.077 P=0.257 P=0.335 | |POLY 3 | P=0.516 P=0.473 P=0.577N P=0.506 |P=0.388N P=0.054 P=0.240 P=0.346 | |POLY 1.5 | P=0.528 P=0.480 P=0.578N P=0.519 |P=0.385N P=0.057 P=0.241 P=0.351 | |POLY 6 | P=0.504 P=0.465 P=0.572N P=0.494 |P=0.395N P=0.053 P=0.238 P=0.339 | |LOGISTIC REGRESSION| P=0.530 P=0.468 P=0.567N P=0.537 |P=0.377N P=0.077 P=0.260 P=0.389 | |COCH-ARM / FISHERS | P=0.547 P=0.491 P=0.577N P=0.538 |P=0.375N P=0.068 P=0.242 P=0.367 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 62 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Stomach, Glandular: Epithelium | | Cyst Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/94 (6%) 10/93 (11%) 10/97 (10%) 3/87 (3%) |23/86 (27%) 19/90 (21%) 17/93 (18%) 12/93 (13%) | |POLY-3 ADJUSTED (b)| 6.8% 11.6% 10.9% 3.9% |28.0% 22.3% 19.4% 13.8% | |TERMINAL (d) | 6/76 (8%) 8/72 (11%) 10/84 (12%) 3/62 (5%) |20/70 (29%) 16/74 (22%) 16/79 (20%) 12/74 (16%) | |FIRST INCIDENCE | 734 (T) 560 734 (T) 734 (T) |608 64 472 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.116N P=0.185 P=0.281 P=0.354N |P=0.035N* P=0.245N P=0.099N P=0.020N* | |POLY 3 | P=0.099N P=0.198 P=0.236 P=0.315N |P=0.027N* P=0.253N P=0.126N P=0.017N* | |POLY 1.5 | P=0.092N P=0.203 P=0.236 P=0.304N |P=0.027N* P=0.248N P=0.123N P=0.016N* | |POLY 6 | P=0.107N P=0.193 P=0.239 P=0.328N |P=0.029N* P=0.259N P=0.133N P=0.018N* | |LOGISTIC REGRESSION| P=0.097N P=0.199 P=0.281 P=0.354N |P=0.026N* P=0.238N P=0.126N P=0.018N* | |COCH-ARM / FISHERS | P=0.081N P=0.210 P=0.237 P=0.288N |P=0.026N* P=0.242N P=0.119N P=0.016N* | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Testes | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 5/98 (5%) 1/100 (1%) 8/96 (8%) | | |POLY-3 ADJUSTED (b)| 3.3% 5.7% 1.1% 9.5% | | |TERMINAL (d) | 1/76 (1%) 3/72 (4%) 1/84 (1%) 5/62 (8%) | | |FIRST INCIDENCE | 684 605 734 (T) 577 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.025 * P=0.328 P=0.286N P=0.066 | | |POLY 3 | P=0.038 * P=0.334 P=0.304N P=0.081 | | |POLY 1.5 | P=0.041 * P=0.342 P=0.304N P=0.087 | | |POLY 6 | P=0.036 * P=0.326 P=0.303N P=0.075 | | |LOGISTIC REGRESSION| P=0.046 * P=0.353 P=0.303N P=0.098 | | |COCH-ARM / FISHERS | P=0.046 * P=0.355 P=0.307N P=0.097 | | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 63 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thymus | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/69 (0%) 0/68 (0%) 0/63 (0%) 0/68 (0%) |1/78 (1%) 2/92 (2%) 3/84 (4%) 3/75 (4%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |1.4% 2.4% 3.9% 4.4% | |TERMINAL (d) | 0/54 (0%) 0/51 (0%) 0/58 (0%) 0/41 (0%) |1/62 (2%) 1/69 (1%) 3/70 (4%) 3/60 (5%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 734 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.298 P=0.533 P=0.351 P=0.295 | |POLY 3 | (e) (e) (e) (e) |P=0.279 P=0.547 P=0.328 P=0.286 | |POLY 1.5 | (e) (e) (e) (e) |P=0.279 P=0.550 P=0.330 P=0.288 | |POLY 6 | (e) (e) (e) (e) |P=0.279 P=0.542 P=0.325 P=0.284 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.298 P=0.536 P=0.351 P=0.295 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.281 P=0.562 P=0.339 P=0.295 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thymus | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 62/69 (90%) 50/68 (74%) 47/63 (75%) 64/68 (94%) |22/78 (28%) 20/92 (22%) 24/84 (29%) 29/75 (39%) | |POLY-3 ADJUSTED (b)| 90.1% 75.1% 75.5% 95.4% |29.5% 23.1% 29.5% 40.1% | |TERMINAL (d) | 48/54 (89%) 35/51 (69%) 43/58 (74%) 39/41 (95%) |14/62 (23%) 10/69 (15%) 14/70 (20%) 21/60 (35%) | |FIRST INCIDENCE | 386 474 430 448 |608 496 513 467 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P<0.001 ** P=0.124N P=0.002N** P=0.014 * |P=0.054 P=0.351N P=0.550 P=0.152 | |POLY 3 | P=0.006 ** P=0.017N* P=0.022N* P=0.189 |P=0.020 * P=0.230N P=0.568N P=0.118 | |POLY 1.5 | P=0.007 ** P=0.014N* P=0.020N* P=0.220 |P=0.019 * P=0.225N P=0.560 P=0.115 | |POLY 6 | P=0.005 ** P=0.018N* P=0.022N* P=0.160 |P=0.022 * P=0.240N P=0.560N P=0.121 | |LOGISTIC REGRESSION| P=0.012 * P=0.010N* P=0.021N* P=0.289 |P=0.019 * P=0.209N P=0.564 P=0.117 | |COCH-ARM / FISHERS | P=0.010 * P=0.012N* P=0.018N* P=0.274 |P=0.018 * P=0.213N P=0.549 P=0.115 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 64 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thymus | | Cyst Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/69 (6%) 10/68 (15%) 9/63 (14%) 4/68 (6%) |5/78 (6%) 2/92 (2%) 3/84 (4%) 9/75 (12%) | |POLY-3 ADJUSTED (b)| 6.3% 16.7% 15.0% 6.9% |6.8% 2.4% 3.8% 13.0% | |TERMINAL (d) | 4/54 (7%) 10/51 (20%) 9/58 (16%) 3/41 (7%) |5/62 (8%) 2/69 (3%) 2/70 (3%) 8/60 (13%) | |FIRST INCIDENCE | 734 (T) 734 (T) 734 (T) 630 |735 (T) 735 (T) 578 715 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.337N P=0.061 P=0.149 P=0.498 |P=0.013 * P=0.179N P=0.301N P=0.185 | |POLY 3 | P=0.218N P=0.061 P=0.100 P=0.592 |P=0.010 * P=0.169N P=0.324N P=0.169 | |POLY 1.5 | P=0.198N P=0.066 P=0.095 P=0.610 |P=0.010 * P=0.166N P=0.323N P=0.172 | |POLY 6 | P=0.243N P=0.056 P=0.109 P=0.571 |P=0.010 * P=0.173N P=0.326N P=0.167 | |LOGISTIC REGRESSION| P=0.256N P=0.061 P=0.149 P=0.572 |P=0.010 * P=0.179N P=0.322N P=0.169 | |COCH-ARM / FISHERS | P=0.175N P=0.074 P=0.089 P=0.633 |P=0.011 * P=0.160N P=0.319N P=0.179 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thymus | | Hyperplasia Lymphoid | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/69 (4%) 5/68 (7%) 9/63 (14%) 0/68 (0%) |31/78 (40%) 19/92 (21%) 20/84 (24%) 24/75 (32%) | |POLY-3 ADJUSTED (b)| 4.7% 8.4% 15.0% 0.0% |42.4% 22.7% 25.7% 34.8% | |TERMINAL (d) | 2/54 (4%) 5/51 (10%) 9/58 (16%) 0/41 (0%) |31/62 (50%) 19/69 (28%) 19/70 (27%) 23/60 (38%) | |FIRST INCIDENCE | 534 734 (T) 734 (T) --- |735 (T) 735 (T) 645 733 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.073N P=0.330 P=0.082 P=0.163N |P=0.388 P=0.007N** P=0.011N* P=0.179N | |POLY 3 | P=0.051N P=0.322 P=0.050 P=0.140N |P=0.336 P=0.006N** P=0.021N* P=0.223N | |POLY 1.5 | P=0.045N* P=0.333 P=0.047 * P=0.133N |P=0.334 P=0.005N** P=0.021N* P=0.219N | |POLY 6 | P=0.061N P=0.310 P=0.054 P=0.150N |P=0.341 P=0.006N** P=0.022N* P=0.228N | |LOGISTIC REGRESSION| P=0.049N* P=0.339 P=0.048 * P=0.103N |P=0.370 P=0.007N** P=0.026N* (e) | |COCH-ARM / FISHERS | P=0.039N* P=0.351 P=0.045 * P=0.125N |P=0.339 P=0.005N** P=0.022N* P=0.204N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 65 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thyroid Gland | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/98 (0%) 0/98 (0%) 0/97 (0%) |0/92 (0%) 0/99 (0%) 3/98 (3%) 1/98 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 3.3% 1.1% | |TERMINAL (d) | 0/76 (0%) 0/71 (0%) 0/84 (0%) 0/61 (0%) |0/70 (0%) 0/73 (0%) 3/79 (4%) 1/74 (1%) | |FIRST INCIDENCE | --- --- --- --- |--- --- 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.508 (e) P=0.145 P=0.511 | |POLY 3 | (e) (e) (e) (e) |P=0.503 (e) P=0.129 P=0.506 | |POLY 1.5 | (e) (e) (e) (e) |P=0.504 (e) P=0.130 P=0.508 | |POLY 6 | (e) (e) (e) (e) |P=0.503 (e) P=0.127 P=0.505 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) P=0.145 P=0.511 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.509 (e) P=0.135 P=0.516 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thyroid Gland | | Inflammation Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/98 (0%) 0/98 (0%) 0/97 (0%) |2/92 (2%) 0/99 (0%) 3/98 (3%) 4/98 (4%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |2.3% 0.0% 3.3% 4.5% | |TERMINAL (d) | 0/76 (0%) 0/71 (0%) 0/84 (0%) 0/61 (0%) |1/70 (1%) 0/73 (0%) 3/79 (4%) 4/74 (5%) | |FIRST INCIDENCE | --- --- --- --- |461 --- 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.114 P=0.233N P=0.545 P=0.362 | |POLY 3 | (e) (e) (e) (e) |P=0.114 P=0.234N P=0.516 P=0.349 | |POLY 1.5 | (e) (e) (e) (e) |P=0.115 P=0.230N P=0.520 P=0.354 | |POLY 6 | (e) (e) (e) (e) |P=0.115 P=0.237N P=0.510 P=0.345 | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.117 P=0.154N P=0.553 P=0.388 | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.117 P=0.231N P=0.530 P=0.372 | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 66 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thyroid Gland: Follicle | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/99 (5%) 13/98 (13%) 7/98 (7%) 8/97 (8%) |21/92 (23%) 21/99 (21%) 25/98 (26%) 22/98 (22%) | |POLY-3 ADJUSTED (b)| 5.4% 14.9% 7.6% 9.5% |24.2% 23.3% 27.2% 24.5% | |TERMINAL (d) | 4/76 (5%) 13/71 (18%) 5/84 (6%) 6/61 (10%) |20/70 (29%) 19/73 (26%) 21/79 (27%) 18/74 (24%) | |FIRST INCIDENCE | 718 734 (T) 585 568 |701 545 513 597 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.476 P=0.029 * P=0.440 P=0.174 |P=0.543 P=0.513N P=0.463 P=0.560N | |POLY 3 | P=0.556N P=0.030 * P=0.386 P=0.231 |P=0.533 P=0.518N P=0.387 P=0.552 | |POLY 1.5 | P=0.533N P=0.034 * P=0.381 P=0.247 |P=0.535 P=0.501N P=0.387 P=0.561 | |POLY 6 | P=0.559 P=0.027 * P=0.395 P=0.214 |P=0.537 P=0.536N P=0.384 P=0.547 | |LOGISTIC REGRESSION| P=0.560N P=0.027 * P=0.376 P=0.222 |P=0.533 P=0.550N P=0.365 P=0.534 | |COCH-ARM / FISHERS | P=0.499N P=0.039 * P=0.377 P=0.271 |P=0.541N P=0.462N P=0.397 P=0.544N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/98 (0%) 0/98 (0%) 0/97 (0%) |3/92 (3%) 5/99 (5%) 1/98 (1%) 1/98 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |3.5% 5.6% 1.1% 1.1% | |TERMINAL (d) | 0/76 (0%) 0/71 (0%) 0/84 (0%) 0/61 (0%) |3/70 (4%) 4/73 (6%) 1/79 (1%) 1/74 (1%) | |FIRST INCIDENCE | --- --- --- --- |735 (T) 509 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.134N P=0.379 P=0.265N P=0.287N | |POLY 3 | (e) (e) (e) (e) |P=0.138N P=0.379 P=0.292N P=0.296N | |POLY 1.5 | (e) (e) (e) (e) |P=0.137N P=0.385 P=0.290N P=0.293N | |POLY 6 | (e) (e) (e) (e) |P=0.138N P=0.373 P=0.295N P=0.298N | |LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.134N P=0.400 P=0.265N P=0.287N | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.133N P=0.402 P=0.287N P=0.287N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 67 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Urinary Bladder | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/98 (4%) 1/95 (1%) 1/95 (1%) 0/93 (0%) |8/79 (10%) 3/87 (3%) 4/94 (4%) 6/89 (7%) | |POLY-3 ADJUSTED (b)| 4.4% 1.2% 1.1% 0.0% |10.6% 3.8% 4.6% 7.3% | |TERMINAL (d) | 4/76 (5%) 1/72 (1%) 1/84 (1%) 0/61 (0%) |8/67 (12%) 3/71 (4%) 4/78 (5%) 6/71 (9%) | |FIRST INCIDENCE | 734 (T) 734 (T) 734 (T) --- |735 (T) 735 (T) 735 (T) 735 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.144N P=0.199N P=0.154N P=0.096N |P=0.487 P=0.088N P=0.119N P=0.346N | |POLY 3 | P=0.127N P=0.202N P=0.187N P=0.079N |P=0.521 P=0.087N P=0.118N P=0.323N | |POLY 1.5 | P=0.124N P=0.198N P=0.190N P=0.076N |P=0.519 P=0.085N P=0.116N P=0.319N | |POLY 6 | P=0.131N P=0.205N P=0.183N P=0.084N |P=0.523 P=0.090N P=0.123N P=0.327N | |LOGISTIC REGRESSION| P=0.144N P=0.199N P=0.154N (e) |P=0.487 P=0.088N P=0.119N P=0.346N | |COCH-ARM / FISHERS | P=0.121N P=0.194N P=0.194N P=0.067N |P=0.520 P=0.078N P=0.113N P=0.304N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |1/92 (1%) 3/97 (3%) 2/98 (2%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| |1.2% 3.4% 2.2% 0.0% | |TERMINAL (d) | |1/70 (1%) 1/74 (1%) 2/79 (3%) 0/74 (0%) | |FIRST INCIDENCE | |735 (T) 705 735 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.158N P=0.321 P=0.542 P=0.489N | |POLY 3 | |P=0.157N P=0.317 P=0.517 P=0.491N | |POLY 1.5 | |P=0.155N P=0.319 P=0.519 P=0.490N | |POLY 6 | |P=0.158N P=0.314 P=0.514 P=0.493N | |LOGISTIC REGRESSION| |P=0.154N P=0.316 P=0.542 (e) | |COCH-ARM / FISHERS | |P=0.151N P=0.331 P=0.524 P=0.482N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 68 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus | | Hydrometra | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |48/92 (52%) 33/97 (34%) 40/98 (41%) 41/99 (41%) | |POLY-3 ADJUSTED (b)| |54.5% 36.5% 42.5% 43.3% | |TERMINAL (d) | |38/70 (54%) 25/74 (34%) 30/79 (38%) 26/74 (35%) | |FIRST INCIDENCE | |542 496 472 474 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.528 P=0.016N* P=0.070N P=0.156N | |POLY 3 | |P=0.423N P=0.011N* P=0.068N P=0.084N | |POLY 1.5 | |P=0.446N P=0.010N* P=0.072N P=0.090N | |POLY 6 | |P=0.395N P=0.011N* P=0.067N P=0.077N | |LOGISTIC REGRESSION| |P=0.476N P=0.011N* P=0.081N P=0.098N | |COCH-ARM / FISHERS | |P=0.461N P=0.009N** P=0.077N P=0.089N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus | | Inflammation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |2/92 (2%) 0/97 (0%) 0/98 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| |2.3% 0.0% 0.0% 0.0% | |TERMINAL (d) | |2/70 (3%) 0/74 (0%) 0/79 (0%) 0/74 (0%) | |FIRST INCIDENCE | |735 (T) --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.361N P=0.227N P=0.213N P=0.227N | |POLY 3 | |P=0.352N P=0.233N P=0.228N P=0.229N | |POLY 1.5 | |P=0.354N P=0.231N P=0.227N P=0.227N | |POLY 6 | |P=0.351N P=0.235N P=0.230N P=0.230N | |LOGISTIC REGRESSION| |P=0.361N (e) (e) (e) | |COCH-ARM / FISHERS | |P=0.356N P=0.236N P=0.233N P=0.231N | |=================================================================================================================================| Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 69 Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 104 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus: Endometrium | | Hyperplasia Cystic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |54/92 (59%) 71/97 (73%) 67/98 (68%) 66/99 (67%) | |POLY-3 ADJUSTED (b)| |60.4% 76.3% 72.7% 72.3% | |TERMINAL (d) | |43/70 (61%) 59/74 (80%) 61/79 (77%) 57/74 (77%) | |FIRST INCIDENCE | |334 387 578 576 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.391 P=0.036 * P=0.207 P=0.126 | |POLY 3 | |P=0.318 P=0.014 * P=0.050 P=0.059 | |POLY 1.5 | |P=0.377 P=0.016 * P=0.065 P=0.081 | |POLY 6 | |P=0.267 P=0.011 * P=0.035 * P=0.042 * | |LOGISTIC REGRESSION| |P=0.462 P=0.020 * P=0.090 P=0.106 | |COCH-ARM / FISHERS | |P=0.527 P=0.025 * P=0.108 P=0.161 | |=================================================================================================================================| (a) Number of tumor-bearing animals / number of animals examined at site. (b) Poly-3 adjusted lifetime tumor incidence. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fishers exact tests compare directly the overall incidence rates For all tests a negative trend is indicated by N (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01).