TDMS Study 89029-11 Pathology Tables
NTP Experiment-Test: 89029-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/29/98 Route: MAGNETIC FIELDS Time: 14:01:32 10(10MGX1)DMBA V 50HZ/1G 10(10MGX1)DMBA V 50HZ/5G v 10(10MGX1)DMBA V 60HZ/1G 10 10(10MGX1)DMBA Facility: Battelle Northwest Chemical CAS #: EMF + DMBA Lock Date: 10/14/97 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 001 10 DMBA CONTROL Include 003 50 HZ/1G 10 DMBA Include 005 50 HZ/5G 10 DMBA Include 004 60 HZ/1G 10 DMBA a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89029-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/29/98 Route: MAGNETIC FIELDS Time: 14:01:32 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 10 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G CONTROL 10 DMBA 10 DMBA 10 DMBA ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 100 100 100 100 Early Deaths Natural Death 6 11 4 3 Moribund Sacrifice 6 4 5 3 Survivors Terminal Sacrifice 88 85 91 94 Animals Examined Microscopically 100 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (98) (99) (100) (100) Angiectasis 6 (6%) 3 (3%) 4 (4%) 3 (3%) Basophilic Focus 4 (4%) 3 (3%) 13 (13%) 7 (7%) Clear Cell Focus 8 (8%) 11 (11%) 14 (14%) 5 (5%) Cyst 1 (1%) Eosinophilic Focus 1 (1%) 2 (2%) Fatty Change 2 (2%) Hematopoietic Cell Proliferation 7 (7%) 5 (5%) 5 (5%) 4 (4%) Infiltration Cellular, Mixed Cell 1 (1%) Mixed Cell Focus 1 (1%) Necrosis 2 (2%) Vacuolization Cytoplasmic 1 (1%) Centrilobular, Necrosis 4 (4%) 6 (6%) 4 (4%) 1 (1%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89029-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/29/98 Route: MAGNETIC FIELDS Time: 14:01:32 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 10 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G CONTROL 10 DMBA 10 DMBA 10 DMBA ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (3) (3) (1) Necrosis 1 (33%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (100) (100) (100) (100) Dilatation 1 (1%) Galactocele 2 (2%) 1 (1%) 3 (3%) Hyperplasia 1 (1%) 1 (1%) 1 (1%) Inflammation, Chronic Active 1 (1%) Skin (19) (8) (13) (10) Cyst Epithelial Inclusion 6 (32%) 3 (23%) 1 (10%) Hyperplasia, Basal Cell 6 (32%) 1 (13%) 1 (8%) Inflammation, Chronic Active 1 (5%) Inflammation, Granulomatous 1 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (98) (100) (100) (100) Inflammation, Chronic 1 (1%) Inflammation, Granulomatous 1 (1%) 1 (1%) 1 (1%) Thrombosis 1 (1%) 3 (3%) 1 (1%) 2 (2%) Alveolar Epithelium, Hyperplasia 21 (21%) 10 (10%) 14 (14%) 10 (10%) Alveolus, Infiltration Cellular, Histiocyte 21 (21%) 18 (18%) 14 (14%) 15 (15%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89029-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/29/98 Route: MAGNETIC FIELDS Time: 14:01:32 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 10 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G CONTROL 10 DMBA 10 DMBA 10 DMBA ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (100) (98) (100) (100) Accumulation, Hyaline Droplet 1 (1%) Hydronephrosis 1 (1%) Infarct 1 (1%) Infiltration Cellular, Mixed Cell 1 (1%) Inflammation, Suppurative 1 (1%) Mineralization 1 (1%) 1 (1%) 5 (5%) 3 (3%) Nephropathy 24 (24%) 15 (15%) 27 (27%) 25 (25%) Thrombosis 1 (1%) Pelvis, Inflammation, Suppurative 1 (1%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------