TDMS Study 89029-11 Pathology Tables
NTP Experiment-Test: 89029-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/29/98
Route: MAGNETIC FIELDS Time: 14:01:32
10(10MGX1)DMBA V 50HZ/1G 10(10MGX1)DMBA V 50HZ/5G v 10(10MGX1)DMBA V 60HZ/1G 10 10(10MGX1)DMBA
Facility: Battelle Northwest
Chemical CAS #: EMF + DMBA
Lock Date: 10/14/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 10 DMBA CONTROL
Include 003 50 HZ/1G 10 DMBA
Include 005 50 HZ/5G 10 DMBA
Include 004 60 HZ/1G 10 DMBA
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89029-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/29/98
Route: MAGNETIC FIELDS Time: 14:01:32
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SPRAGUE-DAWLEY RATS FEMALE 10 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G
CONTROL 10 DMBA 10 DMBA 10 DMBA
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DISPOSITION SUMMARY
Animals Initially In Study 100 100 100 100
Early Deaths
Natural Death 6 11 4 3
Moribund Sacrifice 6 4 5 3
Survivors
Terminal Sacrifice 88 85 91 94
Animals Examined Microscopically 100 100 100 100
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ALIMENTARY SYSTEM
Liver (98) (99) (100) (100)
Angiectasis 6 (6%) 3 (3%) 4 (4%) 3 (3%)
Basophilic Focus 4 (4%) 3 (3%) 13 (13%) 7 (7%)
Clear Cell Focus 8 (8%) 11 (11%) 14 (14%) 5 (5%)
Cyst 1 (1%)
Eosinophilic Focus 1 (1%) 2 (2%)
Fatty Change 2 (2%)
Hematopoietic Cell Proliferation 7 (7%) 5 (5%) 5 (5%) 4 (4%)
Infiltration Cellular, Mixed Cell 1 (1%)
Mixed Cell Focus 1 (1%)
Necrosis 2 (2%)
Vacuolization Cytoplasmic 1 (1%)
Centrilobular, Necrosis 4 (4%) 6 (6%) 4 (4%) 1 (1%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89029-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/29/98
Route: MAGNETIC FIELDS Time: 14:01:32
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 10 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G
CONTROL 10 DMBA 10 DMBA 10 DMBA
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
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HEMATOPOIETIC SYSTEM
Lymph Node (3) (3) (1)
Necrosis 1 (33%)
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INTEGUMENTARY SYSTEM
Mammary Gland (100) (100) (100) (100)
Dilatation 1 (1%)
Galactocele 2 (2%) 1 (1%) 3 (3%)
Hyperplasia 1 (1%) 1 (1%) 1 (1%)
Inflammation, Chronic Active 1 (1%)
Skin (19) (8) (13) (10)
Cyst Epithelial Inclusion 6 (32%) 3 (23%) 1 (10%)
Hyperplasia, Basal Cell 6 (32%) 1 (13%) 1 (8%)
Inflammation, Chronic Active 1 (5%)
Inflammation, Granulomatous 1 (10%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (98) (100) (100) (100)
Inflammation, Chronic 1 (1%)
Inflammation, Granulomatous 1 (1%) 1 (1%) 1 (1%)
Thrombosis 1 (1%) 3 (3%) 1 (1%) 2 (2%)
Alveolar Epithelium, Hyperplasia 21 (21%) 10 (10%) 14 (14%) 10 (10%)
Alveolus, Infiltration Cellular, Histiocyte 21 (21%) 18 (18%) 14 (14%) 15 (15%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89029-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/29/98
Route: MAGNETIC FIELDS Time: 14:01:32
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 10 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G
CONTROL 10 DMBA 10 DMBA 10 DMBA
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (100) (98) (100) (100)
Accumulation, Hyaline Droplet 1 (1%)
Hydronephrosis 1 (1%)
Infarct 1 (1%)
Infiltration Cellular, Mixed Cell 1 (1%)
Inflammation, Suppurative 1 (1%)
Mineralization 1 (1%) 1 (1%) 5 (5%) 3 (3%)
Nephropathy 24 (24%) 15 (15%) 27 (27%) 25 (25%)
Thrombosis 1 (1%)
Pelvis, Inflammation, Suppurative 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
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