TDMS Study 89029-12 Pathology Tables
NTP Experiment-Test: 89029-12 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/30/98
Route: MAGNETIC FIELDS Time: 16:02:02
20MG(5MGX4)DMBA V 50 HZ/1G 20MG(5MGX4)DMBA V 50 HZ/5G 20MG(5MGX4)DMBA V 60 HZ/1G 20MG(5MGX4)DMBA
Facility: Battelle Northwest
Chemical CAS #: EMF + DMBA
Lock Date: 10/14/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 20 DMBA CONTROL
Include 003 50 HZ/1G 20 DMBA
Include 005 50 HZ/5G 20 DMBA
Include 004 60 HZ/1G 20 DMBA
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89029-12 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/30/98
Route: MAGNETIC FIELDS Time: 16:02:02
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SPRAGUE-DAWLEY RATS FEMALE 20 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G
CONTROL 20 DMBA 20 DMBA 20 DMBA
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DISPOSITION SUMMARY
Animals Initially In Study 100 100 100 100
Early Deaths
Natural Death 3 6 4 2
Moribund Sacrifice 3 7 4 3
Survivors
Terminal Sacrifice 93 86 92 94
Natural Death 1 1
Moribund Sacrifice 1
Animals Examined Microscopically 100 100 100 100
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ALIMENTARY SYSTEM
Liver (100) (100) (100) (100)
Angiectasis 1 (1%)
Clear Cell Focus 1 (1%) 3 (3%) 3 (3%)
Fatty Change 2 (2%) 1 (1%) 2 (2%)
Hematopoietic Cell Proliferation 19 (19%) 12 (12%) 12 (12%) 22 (22%)
Hepatodiaphragmatic Nodule 1 (1%)
Necrosis 1 (1%) 1 (1%) 2 (2%)
Centrilobular, Necrosis 1 (1%) 3 (3%) 1 (1%) 1 (1%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89029-12 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/30/98
Route: MAGNETIC FIELDS Time: 16:02:02
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 20 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G
CONTROL 20 DMBA 20 DMBA 20 DMBA
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
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INTEGUMENTARY SYSTEM
Mammary Gland (100) (100) (100) (100)
Dilatation 1 (1%)
Hyperplasia 4 (4%) 3 (3%) 7 (7%)
Inflammation, Chronic 1 (1%) 2 (2%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (100) (100) (100) (100)
Foreign Body 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%)
Thrombosis 1 (1%)
Alveolar Epithelium, Hyperplasia 6 (6%) 5 (5%) 4 (4%)
Alveolus, Infiltration Cellular, Histiocyte 11 (11%) 2 (2%) 15 (15%) 6 (6%)
Trachea (1)
Metaplasia, Squamous 1 (100%)
Mineralization 1 (100%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (100) (100) (100) (100)
Hydronephrosis 1 (1%) 1 (1%)
Infarct 1 (1%)
Inflammation, Chronic Active 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89029-12 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/30/98
Route: MAGNETIC FIELDS Time: 16:02:02
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 20 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G
CONTROL 20 DMBA 20 DMBA 20 DMBA
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mineralization 2 (2%) 1 (1%) 2 (2%)
Nephropathy 15 (15%) 16 (16%) 10 (10%) 16 (16%)
Pelvis, Inflammation, Suppurative 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
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