TDMS Study 89029-12 Pathology Tables
NTP Experiment-Test: 89029-12 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 90-DAY MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/30/98 Route: MAGNETIC FIELDS Time: 16:02:08 MAGNETIC FIELDS + DMBA INITIATION PROMOTION 20MG(5MGX4)DMBA V 50 HZ/1G 20MG(5MGX4)DMBA V 50 HZ/5G 20MG(5MGX4)DMBA V 60 HZ/1G 20MG(5MGX4)DMBA Facility: Battelle Northwest Chemical CAS #: EMF + DMBA Lock Date: 10/14/97 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 001 20 DMBA CONTROL Include 003 50 HZ/1G 20 DMBA Include 005 50 HZ/5G 20 DMBA Include 004 60 HZ/1G 20 DMBA a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89029-12 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 90-DAY MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/30/98 Route: MAGNETIC FIELDS Time: 16:02:08 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 20 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G CONTROL 20 DMBA 20 DMBA 20 DMBA ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 100 100 100 100 Early Deaths Natural Death 3 6 4 2 Moribund Sacrifice 3 7 4 3 Survivors Terminal Sacrifice 93 86 92 94 Natural Death 1 1 Moribund Sacrifice 1 Animals Examined Microscopically 100 100 100 100 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (100) (100) (100) (100) Carcinoma, Metastatic, Mammary Gland 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (2) (2) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 89029-12 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 90-DAY MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/30/98 Route: MAGNETIC FIELDS Time: 16:02:08 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 20 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G CONTROL 20 DMBA 20 DMBA 20 DMBA ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (100) (100) (100) (100) Adenoma 2 (2%) 1 (1%) 1 (1%) Carcinoma 4 (4%) 8 (8%) 9 (9%) 5 (5%) Carcinoma, Multiple 88 (88%) 78 (78%) 87 (87%) 91 (91%) Carcinoma, Metastatic, Zymbal's Gland 1 (1%) Fibroadenoma 3 (3%) 2 (2%) 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (100) (100) (100) (100) Carcinoma, Metastatic, Mammary Gland 1 (1%) 1 (1%) 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (100) (100) (100) (100) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(100) *(100) *(100) *(100) Leukemia Mononuclear 15 (15%) 16 (16%) 10 (10%) 12 (12%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 3 NTP Experiment-Test: 89029-12 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 90-DAY MAGNETIC FIELDS + DMBA INITIATION PROMOTION Date: 01/30/98 Route: MAGNETIC FIELDS Time: 16:02:08 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 20 DMBA 50 HZ/1G 50 HZ/5G 60 HZ/1G CONTROL 20 DMBA 20 DMBA 20 DMBA ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 94 92 96 96 Total Primary Neoplasms 120 109 114 115 Total Animals with Benign Neoplasms 5 3 1 2 Total Benign Neoplasms 5 3 1 2 Total Animals with Malignant Neoplasms 93 92 96 96 Total Malignant Neoplasms 115 106 113 113 Total Animals with Metastatic Neoplasms 1 1 1 2 Total Metastatic Neoplasm 2 1 1 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------