TDMS Study 89029-12 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Northwest MAGNETIC FIELDS + DMBA INITIATION PROMOTION DATE: 01/27/98 EXPERIMENT: 89029 TEST: 12 TIME: 23:53:24 TEST TYPE: SUBCHRON 90-DAY CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-65397 ROUTE: MAGNETIC FIELDS NTP C#: 89029D PATHOLOGIST: GRUMBEIN, S. CAS: EMF+DMBA ------------------------------------------------------------------------------------------------------------------------------------ 20MG(5MGX4)DMBA V 50 HZ/1G 20MG(5MGX4)DMBA V 50 HZ/5G 20MG(5MGX4)DMBA V 60 HZ/1G 20MG(5MGX4)DMBA REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: MERGE 001 001 20 DMBA CONTROL MERGE 002 003 50 HZ/1G 20 DMBA MERGE 003 005 50 HZ/5G 20 DMBA MERGE 004 004 60 HZ/1G 20 DMBA NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Northwest MAGNETIC FIELDS + DMBA INITIATION PROMOTION DATE: 01/27/98 EXPERIMENT: 89029 TEST: 12 TIME: 23:53:24 TEST TYPE: SUBCHRON 90-DAY CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-65397 ROUTE: MAGNETIC FIELDS NTP C#: 89029D PATHOLOGIST: GRUMBEIN, S. CAS: EMF+DMBA MAGNETIC FIELDS + DMBA INITIATION PROMOTION STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 90 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 20 DMBA CONTROL | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 94 | | | | UNCENSORED DEATHS | | 58 72 72 73 75 89 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 50 HZ/1G 20 DMBA | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 87 | | | | UNCENSORED DEATHS | | 49 66 66 72 73 75 81 81 81 82 | | 82 84 84 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 50 HZ/5G 20 DMBA | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 92 | | | | UNCENSORED DEATHS | | 59 65 70 77 77 79 79 84 | | CENSORED DEATHS | | NONE | | | ================================================================================== MAGNETIC FIELDS + DMBA INITIATION PROMOTION STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 90 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 60 HZ/1G 20 DMBA | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 95 | | | | UNCENSORED DEATHS | | 64 70 80 84 89 | | CENSORED DEATHS | | NONE | | | ================================================================================== MAGNETIC FIELDS + DMBA INITIATION PROMOTION STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 90 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 90 (A) | | | |--------------------------------------------------------------------------------| | | | |20 | 94.0 94.0 94.0 94.0 94.0 94.0 94.0 94.0 94.0 94.0 | |DMBA CONTRO| | | | | |50 | 87.0 87.0 87.0 87.0 87.0 87.0 87.0 87.0 87.0 87.0 | |HZ/1G 20 DM|A | | | | |50 | 92.0 92.0 92.0 92.0 92.0 92.0 92.0 92.0 92.0 92.0 | |HZ/5G 20 DM|A | | | | |60 | 95.0 95.0 95.0 95.0 95.0 95.0 95.0 95.0 95.0 95.0 | |HZ/1G 20 DM|A | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 20 50 50 60 | | DMBA CONTROL HZ/1G 20 DMBAHZ/5G 20 DMBAHZ/1G 20 |MBA |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 94.0% 87.0% 92.0% 95.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | ----- ----- ----- ----- | |(LIFE TABLE) | | | | | |MEAN DAY OF | 73.2 75.1 73.8 77.4 | |NATURAL DEATHS (C) | ( 4.0) ( 2.8) ( 3.0) ( 4.6) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 89.0 88.1 88.7 89.4 | |(STANDARD ERROR) | ( 0.5) ( 0.6) ( 0.5) ( 0.3) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) MAGNETIC FIELDS + DMBA INITIATION PROMOTION KAPLAN-MEIER SURVIVAL CURVES 20 DMBA CONTROL = 1 50 HZ/1G 20 DMBA = 2 50 HZ/5G 20 DMBA = 3 60 HZ/1G 20 DMBA = 4 ----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 1 4 | | 2 1 2 1 | 98 + 4 4 | P | 2 2 E | R 96 + 4 4 C | E | 1 3 1 N | T 94 + 2 2 1 | S | U | R 92 + 3 3 V | I | V | A 90 + L | | | 88 + | | 2 2 | 86 + | ---+--------+--------+--------+--------+--------+--------+--------+--------+--------+--------+--------+--------+--------+-- 0 1 2 3 4 5 6 7 8 9 10 11 12 13 WEEK NOTE: 10 obs hidden.