TDMS Study 89029-13 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest MAGNETIC FIELDS + DMBA INITIATION PROMOTION DATE: 12/20/97
EXPERIMENT: 89029 TEST: 13 TIME: 14:42:34
TEST TYPE: SUBCHRON 90-DAY CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65397 ROUTE: MAGNETIC FIELDS NTP C#: 89029D
PATHOLOGIST: GRUMBEIN, SONDRA CAS: EMF+DMBA
------------------------------------------------------------------------------------------------------------------------------------
8MG(2MGX4)DMBA VS 50 HZ/1G 8MG(2MGX4)DMBA VS 50 HZ/5G 8MG(2MGX4)DMBA
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest MAGNETIC FIELDS + DMBA INITIATION PROMOTION DATE: 12/20/97
EXPERIMENT: 89029 TEST: 13 TIME: 14:42:34
TEST TYPE: SUBCHRON 90-DAY CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65397 ROUTE: MAGNETIC FIELDS NTP C#: 89029D
PATHOLOGIST: GRUMBEIN, SONDRA CAS: EMF+DMBA
MAGNETIC FIELDS + DMBA INITIATION PROMOTION
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 92 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 8 DMBA CONTROL |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 100 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 HZ/1G 8 DMBA |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 100 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 HZ/5G 8 DMBA |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 99 |
| |
| UNCENSORED DEATHS |
| 81 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MAGNETIC FIELDS + DMBA INITIATION PROMOTION
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 92 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 92 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|8 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|DMBA CONTR|L |
| | |
|50 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|HZ/1G 8 DMB| |
| | |
|50 | 99.0 99.0 99.0 99.0 99.0 99.0 99.0 99.0 99.0 99.0 |
|HZ/5G 8 DMB| |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 8 50 50 |
| DMBA CONTROL HZ/1G 8 DMBA HZ/5G 8 DMBA |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 100.0% 99.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . . 81.0 |
|NATURAL DEATHS (C) | ( . ) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 92.0 92.0 91.9 |
|(STANDARD ERROR) | ( 0.0) ( 0.0) ( 0.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MAGNETIC FIELDS + DMBA INITIATION PROMOTION
KAPLAN-MEIER SURVIVAL CURVES
8 DMBA CONTROL = 1
50 HZ/1G 8 DMBA = 2
50 HZ/5G 8 DMBA = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 3 obs hidden.)
P |
E |
R 100 + 1 3 1
C |
E |
N |
T 99 + 3 3
|
S ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
U 0 2 4 6 8 10 12 14
R
WEEK