TDMS Study 90004-06 Pathology Tables
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
FINAL/MICE
Facility: Battelle Northwest
Chemical CAS #: 57018-52-7
Lock Date: 12/11/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 8 10 6 4
Natural Death 3 3 2 6
Accidently Killed 1 1
Survivors
Terminal Sacrifice 39 36 41 38
Natural Death 1 1
Animals Examined Microscopically 50 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (40) (39) (43) (33)
Cyst 1 (3%)
Intestine Large, Colon (48) (49) (50) (48)
Infiltration Cellular, Mixed Cell 1 (2%)
Intestine Large, Rectum (48) (49) (50) (48)
Necrosis 1 (2%)
Intestine Large, Cecum (49) (48) (49) (46)
Necrosis 2 (4%)
Intestine Small, Duodenum (49) (47) (50) (46)
Infiltration Cellular, Mixed Cell 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (49) (48) (48) (47)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Intestine Small, Ileum (49) (48) (48) (45)
Hyperplasia 1 (2%)
Infiltration Cellular, Mixed Cell 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Necrosis 2 (4%)
Epithelium, Hyperplasia 1 (2%)
Liver (49) (50) (50) (49)
Angiectasis 1 (2%)
Basophilic Focus 3 (6%) 4 (8%) 4 (8%) 2 (4%)
Clear Cell Focus 4 (8%) 4 (8%) 6 (12%) 5 (10%)
Eosinophilic Focus 11 (22%) 10 (20%) 9 (18%) 27 (55%)
Fatty Change 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Fatty Change, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infarct 1 (2%)
Inflammation, Granulomatous 23 (47%) 9 (18%) 17 (34%) 12 (24%)
Tension Lipidosis 4 (8%) 3 (6%) 6 (12%) 4 (8%)
Thrombosis 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%)
Centrilobular, Necrosis 3 (6%)
Hepatocyte, Mitotic Alteration 1 (2%)
Mesentery (17) (21) (13) (2)
Infiltration Cellular, Mast Cell 1 (6%)
Fat, Congestion 1 (6%)
Fat, Necrosis 14 (82%) 19 (90%) 12 (92%) 2 (100%)
Oral Mucosa (1)
Inflammation 1 (100%)
Pancreas (49) (50) (50) (48)
Atrophy 1 (2%) 2 (4%)
Basophilic Focus 1 (2%) 1 (2%) 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (50) (50) (50) (49)
Atrophy 1 (2%)
Stomach, Forestomach (49) (50) (50) (48)
Hyperplasia, Squamous 3 (6%) 5 (10%) 1 (2%) 6 (13%)
Infiltration Cellular, Mast Cell 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation 2 (4%) 5 (10%) 2 (4%) 6 (13%)
Ulcer 2 (4%) 1 (2%) 4 (8%)
Stomach, Glandular (49) (48) (50) (48)
Mineralization 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Tooth (50) (50) (50) (49)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%) 7 (14%)
Malformation 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Inflammation, Chronic 1 (50%)
Heart (50) (50) (50) (49)
Cardiomyopathy 5 (10%) 4 (8%) 8 (16%) 3 (6%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Endocardium, Hyperplasia 1 (2%)
Valve, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (48)
Hyperplasia 8 (16%) 3 (6%) 3 (6%) 4 (8%)
Hypertrophy 7 (14%) 7 (14%) 1 (2%) 2 (4%)
Necrosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 3 (6%) 3 (6%)
Adrenal Medulla (47) (49) (50) (48)
Hyperplasia 2 (4%) 4 (8%) 1 (2%) 3 (6%)
Hypertrophy 1 (2%)
Necrosis 1 (2%)
Islets, Pancreatic (49) (50) (50) (48)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (48) (49) (47) (46)
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 16 (33%) 11 (22%) 16 (34%) 11 (24%)
Thyroid Gland (49) (50) (50) (48)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (2)
Inflammation, Chronic, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (42) (43) (48) (45)
Inflammation, Chronic 1 (2%)
Ovary (50) (49) (49) (48)
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (2%)
Cyst 12 (24%) 12 (24%) 12 (24%) 11 (23%)
Inflammation, Chronic Active 1 (2%)
Thrombosis 1 (2%)
Uterus (50) (50) (50) (48)
Angiectasis 3 (6%) 1 (2%) 4 (8%) 2 (4%)
Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Thrombosis 2 (4%)
Endometrium, Fibrosis 1 (2%)
Endometrium, Hyperplasia, Cystic 46 (92%) 48 (96%) 48 (96%) 45 (94%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (48)
Thrombosis 1 (2%)
Lymph Node (4) (8) (6) (2)
Angiectasis 2 (25%)
Ectasia 1 (17%)
Lumbar, Angiectasis 1 (25%)
Renal, Angiectasis 1 (25%)
Renal, Ectasia 1 (25%)
Lymph Node, Mandibular (44) (45) (45) (34)
Hyperplasia, Lymphoid 1 (3%)
Infiltration Cellular, Plasma Cell 1 (3%)
Lymph Node, Mesenteric (48) (48) (48) (48)
Angiectasis 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Lymph Node, Mediastinal (40) (41) (41) (31)
Hemorrhage 1 (3%)
Spleen (49) (50) (50) (48)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 4 (8%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (49)
Hyperplasia, Squamous 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 3 (6%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Synovial Tissue, Hyperplasia 1 (2%)
Skeletal Muscle (1) (2)
Hemorrhage 1 (100%)
Inflammation, Acute 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 (2%)
Spinal Cord (2)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (48)
Metaplasia, Squamous 1 (2%)
Lung (50) (50) (50) (49)
Foreign Body 1 (2%)
Inflammation, Granulomatous 2 (4%)
Mineralization 1 (2%)
Thrombosis 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%) 4 (8%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 3 (6%)
Artery, Inflammation, Acute 2 (4%)
Nose (50) (50) (49) (49)
Inflammation, Acute 1 (2%)
Inflammation, Suppurative 3 (6%) 1 (2%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%)
Respiratory Epithelium, Necrosis 2 (4%) 1 (2%)
Pleura (1) (1)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (48)
Cataract 2 (4%)
Anterior Chamber, Inflammation, Acute 1 (2%) 1 (2%)
Cornea, Erosion 3 (6%)
Cornea, Hyperplasia, Squamous 1 (2%) 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Cornea, Inflammation, Acute 1 (2%)
Cornea, Inflammation, Chronic Active 1 (2%) 2 (4%) 4 (8%)
Cornea, Mineralization 1 (2%) 2 (4%) 20 (42%)
Cornea, Ulcer 1 (2%) 1 (2%)
Retrobulbar, Inflammation, Granulomatous 1 (2%)
Harderian Gland (50) (50) (50) (49)
Hyperplasia 3 (6%) 3 (6%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (48)
Infarct 1 (2%) 2 (4%) 3 (6%)
Metaplasia, Osseous 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Nephropathy 34 (69%) 34 (68%) 32 (64%) 34 (71%)
Thrombosis 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Degeneration, Hyaline 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Urinary Bladder (50) (49) (50) (47)
Inflammation, Acute 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 11 4 4 5
Moribund Sacrifice 4 6 6 8
Survivors
Terminal Sacrifice 35 40 40 37
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (38) (41) (39) (40)
Degeneration, Hyaline 1 (2%) 2 (5%)
Intestine Large, Colon (46) (48) (48) (47)
Serosa, Inflammation, Granulomatous 1 (2%)
Intestine Large, Rectum (46) (48) (48) (46)
Infiltration Cellular, Mixed Cell 1 (2%)
Intestine Large, Cecum (43) (47) (48) (48)
Necrosis 1 (2%) 1 (2%)
Intestine Small, Jejunum (42) (47) (47) (45)
Infiltration Cellular, Mixed Cell 2 (5%) 2 (4%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Necrosis 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Ileum (43) (47) (46) (46)
Infiltration Cellular, Mixed Cell 4 (9%) 2 (4%) 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Liver (50) (49) (50) (50)
Basophilic Focus 6 (12%) 11 (22%) 16 (32%) 4 (8%)
Clear Cell Focus 20 (40%) 18 (37%) 16 (32%) 17 (34%)
Eosinophilic Focus 9 (18%) 14 (29%) 11 (22%) 29 (58%)
Fatty Change 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Infarct 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Inflammation, Granulomatous 9 (18%) 12 (24%) 11 (22%) 3 (6%)
Mixed Cell Focus 4 (8%)
Tension Lipidosis 1 (2%) 2 (4%) 4 (8%) 2 (4%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Multinucleated 27 (54%) 23 (47%) 24 (48%) 46 (92%)
Mesentery (14) (16) (13) (11)
Inflammation, Granulomatous 2 (14%) 1 (6%) 4 (31%) 1 (9%)
Artery, Inflammation 1 (8%) 2 (18%)
Fat, Necrosis 10 (71%) 14 (88%) 7 (54%) 7 (64%)
Pancreas (48) (49) (50) (50)
Atrophy 1 (2%)
Basophilic Focus 1 (2%)
Stomach, Forestomach (48) (49) (50) (50)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation 2 (4%) 3 (6%) 9 (18%) 9 (18%)
Ulcer 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Epithelium, Hyperplasia, Squamous 2 (4%) 5 (10%) 9 (18%) 7 (14%)
Epithelium, Ulcer 1 (2%) 1 (2%) 3 (6%) 3 (6%)
Stomach, Glandular (46) (48) (50) (48)
Hyperplasia 1 (2%)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%)
Tooth (50) (50) (50) (50)
Inflammation, Chronic Active 3 (6%) 5 (10%) 4 (8%) 15 (30%)
Malformation 24 (48%) 15 (30%) 15 (30%) 16 (32%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 9 (18%) 8 (16%) 11 (22%) 7 (14%)
Mineralization 1 (2%) 1 (2%)
Necrosis 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (48) (49) (50) (50)
Hyperplasia 11 (23%) 9 (18%) 14 (28%) 7 (14%)
Hypertrophy 34 (71%) 32 (65%) 29 (58%) 18 (36%)
Adrenal Medulla (47) (49) (49) (49)
Hyperplasia 1 (2%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Infiltration Cellular, Polymorphonuclear 1 (2%)
Islets, Pancreatic (48) (49) (50) (50)
Hyperplasia 1 (2%)
Pituitary Gland (43) (48) (50) (48)
Cyst 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 4 (8%) 1 (2%)
Thyroid Gland (48) (48) (49) (49)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Preputial Gland (50) (50) (50) (50)
Ectasia 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (2%) 2 (4%)
Inflammation, Chronic 2 (4%) 2 (4%)
Inflammation, Suppurative 3 (6%) 2 (4%) 2 (4%)
Prostate (49) (49) (47) (50)
Inflammation, Suppurative 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Seminal Vesicle (47) (49) (49) (49)
Inflammation, Chronic 2 (4%) 1 (2%)
Testes (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Atrophy 1 (2%) 1 (2%)
Mineralization 1 (2%)
Germinal Epithelium, Degeneration 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50) (50)
Thrombosis 1 (2%)
Lymph Node, Bronchial (32) (36) (36) (35)
Infiltration Cellular, Plasma Cell 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (28) (38) (30) (25)
Infiltration Cellular, Plasma Cell 1 (4%)
Lymph Node, Mesenteric (48) (49) (49) (50)
Angiectasis 1 (2%)
Infiltration Cellular, Plasma Cell 2 (4%) 1 (2%) 4 (8%)
Infiltration Cellular, Mixed Cell 1 (2%)
Pigmentation 1 (2%)
Lymph Node, Mediastinal (39) (39) (43) (36)
Inflammation, Granulomatous 1 (3%)
Spleen (48) (48) (50) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 2 (4%) 2 (4%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (50) (50)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic Active 4 (8%) 1 (2%) 6 (12%) 5 (10%)
Epidermis, Hyperplasia 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Necrosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (50) (50) (50)
Artery, Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Thrombosis 3 (6%)
Alveolar Epithelium, Hyperplasia 6 (12%) 4 (8%) 4 (8%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%)
Nose (50) (49) (50) (50)
Amyloid Deposition 1 (2%)
Inflammation, Suppurative 5 (10%) 4 (8%) 6 (12%)
Olfactory Epithelium, Atrophy 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Necrosis 1 (2%) 1 (2%)
Pleura (1) (1)
Necrosis, Fatty 1 (100%)
Trachea (48) (48) (50) (50)
Degeneration, Hyaline 1 (2%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (48) (49) (50) (50)
Cornea, Erosion 1 (2%)
Cornea, Hyperplasia, Squamous 1 (2%) 1 (2%)
Cornea, Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Cornea, Mineralization 3 (6%)
Harderian Gland (50) (50) (50) (50)
Hyperplasia 10 (20%) 3 (6%) 5 (10%) 1 (2%)
Zymbal's Gland (35) (35) (36) (32)
Hyperplasia 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50)
Amyloid Deposition 1 (2%)
Cyst 1 (2%) 1 (2%) 2 (4%)
Infarct 3 (6%) 3 (6%) 3 (6%) 7 (14%)
Inflammation, Chronic, Suppurative 1 (2%) 1 (2%)
Metaplasia, Osseous 3 (6%) 6 (12%) 2 (4%)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 90004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 01/02/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:46:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Nephropathy 41 (82%) 40 (82%) 44 (88%) 36 (72%)
Artery, Inflammation, Chronic Active 2 (4%) 1 (2%)
Papilla, Inflammation, Suppurative 1 (2%)
Pelvis, Dilatation 1 (2%) 2 (4%)
Renal Tubule, Hyperplasia 2 (4%) 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%)
Urinary Bladder (48) (48) (49) (50)
Inflammation, Chronic Active 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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