TDMS Study 90004-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest PROPYLENE GLYCOL MONO-T-BUTYL ETHER DATE: 01/02/02
EXPERIMENT: 90004 TEST: 06 TIME: 09:24:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C90004
PATHOLOGIST: MISSING CAS: 57018-52-7
------------------------------------------------------------------------------------------------------------------------------------
FINAL/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest PROPYLENE GLYCOL MONO-T-BUTYL ETHER DATE: 01/02/02
EXPERIMENT: 90004 TEST: 06 TIME: 09:24:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C90004
PATHOLOGIST: MISSING CAS: 57018-52-7
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 281 610 622 630 634 641 668 669 669 671 |
| 693 708 711 714 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 137 137 466 568 611 627 630 663 705 712 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 451 463 531 562 564 596 606 641 642 702 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 325 526 527 560 599 600 632 637 642 643 |
| 672 705 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 98.0 88.0 70.0 |
| | |
| | |
|75 PPM | 100.0 96.0 96.0 96.0 96.0 94.0 94.0 92.0 84.0 80.0 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 88.0 82.0 80.0 |
| | |
| | |
|1200 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 94.0 88.0 80.0 74.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 75 PPM 300 PPM 1200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 80.0% 80.0% 74.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.927 P=0.430N P=0.462N P=0.931N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 642.9 525.6 575.8 598.4 |
|NATURAL DEATHS (C) | (27.4) (68.4) (25.1) (28.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 703.2 688.3 698.4 695.0 |
|(STANDARD ERROR) | ( 9.8) (17.5) (10.0) (10.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 588 624 638 653 680 680 683 691 701 705 |
| 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 533 586 602 630 643 669 680 686 694 695 |
| 705 725 730 |
| CENSORED DEATHS |
| 616 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 600 641 655 656 658 669 711 717 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 1 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 440 501 519 585 632 666 681 694 722 722 |
| CENSORED DEATHS |
| 6 |
| |
==================================================================================
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 78.0 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 89.9 73.6 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 90.0 84.0 |
| | |
| | |
|1200 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 93.9 91.8 89.8 79.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 75 PPM 300 PPM 1200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 73.6% 84.0% 79.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.878N P=0.749 P=0.612N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 669.8 659.8 663.4 616.2 |
|NATURAL DEATHS (C) | (12.1) (16.2) (13.3) (31.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 717.5 710.2 720.2 693.5 |
|(STANDARD ERROR) | ( 4.4) ( 6.3) ( 4.1) (16.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
75 PPM = 2
300 PPM = 3
1200 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 4 3
|
| 1 4 3 3 4 1
|
96 + 2 2 3 11
|
| 2 3 432 11
|
P 92 + 4 2 4 2 11
E |
R | 3 3 2 211
C |
E 88 + 33 41 1
N |
T | 3 2 3 2
|
S 84 + 44 2 2
U |
R | 3 22
V |
I 80 + 4 1 1 32 2
V |
A | 4 1 41
L |
76 + 44
|
| 4 4
|
72 + 1 1
|
| 1 1
|
68 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
75 PPM = 2
300 PPM = 3
1200 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1 3
|
| 4 4 2 1 3 1 3
| 4 4 2 2 1 1 3
P 95 +
E | 4 4 2 2 1 1
R | 2 2 1 1
C | 4 4
E 90 + 42 3 2
N |
T | 2 2 3
| 114 33
S 85 +
U | 2121 34 3
R |
V |
I 80 + 21 1 4
V |
A | 2 1 1
L |
75 + 2 2
| 2
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.