TDMS Study 90004-07 Pathology Tables
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
FINAL#2/RATS
Facility: Battelle Northwest
Chemical CAS #: 57018-52-7
Lock Date: 12/11/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 14 12 20 11
Natural Death 3 4 2 3
Survivors
Terminal Sacrifice 33 34 28 36
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (49) (50) (50) (50)
Angiectasis 1 (2%) 3 (6%) 1 (2%)
Basophilic Focus 39 (80%) 45 (90%) 43 (86%) 40 (80%)
Clear Cell Focus 12 (24%) 13 (26%) 11 (22%) 27 (54%)
Eosinophilic Focus 1 (2%) 1 (2%)
Fatty Change 1 (2%)
Hepatodiaphragmatic Nodule 8 (16%) 10 (20%) 9 (18%) 7 (14%)
Infarct 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%) 2 (4%)
Necrosis 1 (2%) 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 3 (6%) 4 (8%) 3 (6%)
Bile Duct, Dilatation 1 (2%)
Serosa, Hemorrhage 1 (2%)
Mesentery (17) (23) (10) (17)
Necrosis 17 (100%) 21 (91%) 9 (90%) 17 (100%)
Fat, Hemorrhage 1 (6%) 1 (4%)
Pancreas (49) (50) (50) (50)
Cyst 1 (2%)
Necrosis 1 (2%)
Stomach, Forestomach (49) (50) (50) (49)
Erosion 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 4 (8%)
Stomach, Glandular (49) (50) (50) (49)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Tongue (2) (1)
Epithelium, Hyperkeratosis 1 (100%)
Epithelium, Hyperplasia 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tooth (1)
Peridontal Tissue, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 3 (6%) 1 (2%)
Atrium, Thrombosis 2 (4%)
Epicardium, Inflammation, Chronic 1 (2%)
Myocardium, Degeneration 1 (2%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Atrophy 1 (2%)
Degeneration, Cystic 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Vacuolization Cytoplasmic 15 (31%) 10 (20%) 6 (12%) 5 (10%)
Adrenal Medulla (49) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Pituitary Gland (49) (50) (50) (49)
Angiectasis 4 (8%) 4 (8%) 1 (2%) 4 (8%)
Cyst 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 3 (6%) 6 (12%) 3 (6%) 3 (6%)
Pars Intermedia, Vacuolization Cytoplasmic 1 (2%)
Thyroid Gland (49) (50) (50) (50)
C-Cell, Hyperplasia 9 (18%) 8 (16%) 7 (14%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Clitoral Gland (50) (50) (50) (50)
Cyst 2 (4%) 3 (6%) 1 (2%) 4 (8%)
Hyperplasia 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 6 (12%) 5 (10%) 3 (6%) 8 (16%)
Hemorrhage 1 (2%)
Uterus (50) (50) (50) (50)
Decidual Reaction 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hemorrhage, Chronic 1 (2%)
Necrosis 1 (2%)
Endometrium, Hyperplasia 1 (2%) 2 (4%)
Endometrium, Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (5) (3) (3) (6)
Deep Cervical, Infiltration Cellular,
Histiocyte 1 (33%)
Deep Cervical, Inflammation, Chronic 1 (20%)
Lymph Node, Bronchial (9) (4) (10) (5)
Angiectasis 1 (11%) 1 (20%)
Infiltration Cellular, Histiocyte 1 (10%)
Lymph Node, Mandibular (1) (2) (2)
Ectasia 1 (50%) 1 (50%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Lymph Node, Mediastinal (43) (46) (45) (43)
Angiectasis 3 (7%) 1 (2%) 1 (2%) 2 (5%)
Fibrosis 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 2 (4%) 4 (9%)
Inflammation, Suppurative 1 (2%)
Pigmentation 3 (7%) 1 (2%)
Spleen (49) (50) (50) (50)
Accessory Spleen 1 (2%) 2 (4%)
Degeneration 1 (2%)
Fibrosis 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50) (50)
Galactocele 7 (14%) 2 (4%) 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%)
Maxilla, Necrosis 1 (2%)
Metatarsal, Fracture 1 (2%)
Tibia, Osteopetrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Compression 5 (10%) 9 (18%) 8 (16%) 4 (8%)
Hemorrhage 4 (8%) 3 (6%) 6 (12%) 2 (4%)
Hydrocephalus 1 (2%)
Medulla, Gliosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (50) (50) (50)
Foreign Body 1 (2%) 1 (2%)
Inflammation, Suppurative 4 (8%) 2 (4%) 1 (2%) 2 (4%)
Epiglottis, Metaplasia, Squamous 1 (2%) 2 (4%)
Respiratory Epithelium, Epiglottis,
Degeneration 1 (2%)
Lung (50) (50) (50) (50)
Foreign Body 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic 9 (18%) 2 (4%) 7 (14%) 6 (12%)
Metaplasia, Osseous 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 4 (8%) 5 (10%) 4 (8%)
Alveolus, Infiltration Cellular, Histiocyte 15 (30%) 9 (18%) 13 (26%) 20 (40%)
Alveolus, Proteinosis 4 (8%) 3 (6%) 2 (4%)
Bronchiole, Hyperplasia 1 (2%) 1 (2%)
Interstitium, Fibrosis 4 (8%) 1 (2%) 4 (8%) 2 (4%)
Mediastinum, Inflammation, Granulomatous 1 (2%)
Nose (49) (49) (50) (50)
Foreign Body 2 (4%) 2 (4%) 2 (4%)
Inflammation, Suppurative 4 (8%) 2 (4%) 5 (10%)
Glands, Dilatation 4 (8%)
Goblet Cell, Hyperplasia 3 (6%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%) 4 (8%) 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 10 (20%) 22 (45%) 48 (96%) 50 (100%)
Respiratory Epithelium, Hyperplasia 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Pleura (50) (50) (49) (50)
Inflammation, Chronic 15 (30%) 10 (20%) 11 (22%) 17 (34%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (50) (50)
Atrophy 2 (4%)
Phthisis Bulbi 1 (2%) 1 (2%)
Anterior Chamber, Sclera, Inflammation,
Suppurative 1 (2%)
Cornea, Edema 1 (2%)
Cornea, Inflammation, Chronic 1 (2%) 1 (2%)
Cornea, Mineralization 10 (20%)
Cornea, Necrosis 1 (2%)
Lens, Cataract 1 (2%) 4 (8%) 3 (6%) 1 (2%)
Lens, Mineralization 1 (2%)
Sclera, Inflammation, Suppurative 1 (2%)
Zymbal's Gland (42) (44) (43) (46)
Cyst 1 (2%)
Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Kidney (49) (50) (50) (50)
Inflammation, Suppurative 2 (4%)
Nephropathy, Chronic 45 (92%) 45 (90%) 45 (90%) 49 (98%)
Cortex, Infarct 1 (2%)
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 1 (2%) 2 (4%) 1 (2%)
Cortex, Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Pelvis, Mineralization 13 (27%) 5 (10%) 7 (14%) 3 (6%)
Pelvis, Transitional Epithelium, Hyperplasia 4 (8%)
Renal Tubule, Mineralization 2 (4%)
Urethra (1)
Transitional Epithelium, Hyperplasia 1 (100%)
Urinary Bladder (49) (50) (50) (50)
Hemorrhage 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Transitional Epithelium, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 20 15 26 22
Natural Death 3 6 8 6
Survivors
Terminal Sacrifice 27 29 16 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (50) (48) (47) (48)
Diverticulum 1 (2%)
Intestine Large, Cecum (47) (47) (47) (45)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Intestine Small, Duodenum (48) (47) (47) (47)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (47) (47) (42) (46)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Ileum (47) (47) (43) (45)
Epithelium, Hyperplasia 1 (2%)
Liver (50) (50) (49) (50)
Basophilic Focus 6 (12%) 18 (36%) 15 (31%) 17 (34%)
Clear Cell Focus 8 (16%) 11 (22%) 11 (22%) 9 (18%)
Degeneration, Cystic 1 (2%) 1 (2%) 3 (6%)
Eosinophilic Focus 1 (2%) 1 (2%) 2 (4%)
Fatty Change 3 (6%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 6 (12%) 11 (22%) 5 (10%)
Necrosis 3 (6%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Dilatation 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%)
Hepatocyte, Regeneration 1 (2%)
Mesentery (13) (9) (10) (7)
Necrosis 13 (100%) 9 (100%) 10 (100%) 5 (71%)
Thrombosis 1 (14%)
Fat, Hemorrhage 1 (11%)
Oral Mucosa (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer 1 (100%)
Pancreas (50) (50) (49) (50)
Acinus, Atrophy 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%)
Stomach, Forestomach (50) (50) (49) (50)
Hyperplasia, Squamous 2 (4%) 1 (2%) 2 (4%) 4 (8%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Ulcer 3 (6%) 3 (6%) 4 (8%)
Stomach, Glandular (50) (50) (49) (50)
Erosion 3 (6%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Tongue (2) (3) (1)
Epithelium, Hyperplasia 2 (100%) 3 (100%) 1 (100%)
Tooth (1) (2) (1)
Malformation 1 (50%)
Peridontal Tissue, Inflammation 1 (100%) 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (49) (50)
Pulmonary Artery, Degeneration, Mucoid 1 (2%)
Heart (50) (50) (49) (50)
Cardiomyopathy 7 (14%) 6 (12%) 4 (8%) 7 (14%)
Inflammation, Focal, Suppurative 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%)
Myocardium, Fibrosis 1 (2%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Hyperplasia 1 (2%) 3 (6%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 6 (12%) 14 (28%) 6 (12%) 9 (18%)
Adrenal Medulla (50) (50) (49) (50)
Hyperplasia 6 (12%) 4 (8%) 11 (22%) 9 (18%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thrombosis 1 (2%)
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (49) (49) (48) (49)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (49) (50)
Angiectasis 1 (2%) 3 (6%) 1 (2%)
Atrophy 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%)
Hyperplasia 5 (10%) 2 (4%) 4 (8%) 2 (4%)
Thyroid Gland (50) (50) (49) (50)
C-Cell, Hyperplasia 8 (16%) 4 (8%) 7 (14%) 7 (14%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (1)
Necrosis 1 (100%)
Preputial Gland (50) (50) (49) (50)
Hyperplasia 2 (4%) 3 (6%) 3 (6%)
Inflammation, Suppurative 4 (8%) 4 (8%)
Prostate (50) (50) (49) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 31 (62%) 24 (48%) 27 (55%) 27 (54%)
Seminal Vesicle (50) (50) (49) (50)
Dilatation 1 (2%)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Testes (50) (50) (49) (50)
Bilateral, Interstitial Cell, Hyperplasia 1 (2%) 1 (2%)
Germinal Epithelium, Atrophy 20 (40%) 19 (38%) 18 (37%) 20 (40%)
Interstitial Cell, Hyperplasia 4 (8%) 3 (6%) 7 (14%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node (12) (7) (15) (6)
Deep Cervical, Ectasia 1 (14%)
Deep Cervical, Hyperplasia, Lymphoid 1 (8%)
Deep Cervical, Inflammation 1 (14%)
Deep Cervical, Inflammation, Suppurative 1 (17%)
Pancreatic, Ectasia 1 (8%)
Pancreatic, Hemorrhage 1 (7%)
Pancreatic, Pigmentation 1 (14%)
Lymph Node, Bronchial (24) (7) (9) (21)
Hemorrhage 1 (11%)
Hyperplasia, Lymphoid 2 (10%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Ectasia 1 (2%)
Fibrosis 1 (2%)
Lymph Node, Mediastinal (38) (41) (46) (45)
Angiectasis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (3%) 1 (2%)
Spleen (50) (50) (49) (50)
Accessory Spleen 2 (4%) 3 (6%) 4 (8%) 1 (2%)
Fibrosis 5 (10%) 1 (2%) 7 (14%) 4 (8%)
Hemorrhage 1 (2%) 1 (2%) 3 (6%)
Necrosis 1 (2%) 2 (4%) 5 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Galactocele 3 (6%) 2 (4%) 2 (4%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Epithelium, Cyst, Squamous 1 (2%)
Skin (50) (50) (49) (50)
Cyst Epithelial Inclusion 3 (6%) 5 (10%) 3 (6%) 1 (2%)
Hyperkeratosis 3 (6%) 1 (2%) 6 (12%) 1 (2%)
Inflammation, Granulomatous 2 (4%)
Ulcer 1 (2%) 2 (4%)
Prepuce, Ulcer 1 (2%)
Sebaceous Gland, Hyperplasia, Squamous 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Fibrous Osteodystrophy 1 (2%)
Cranium, Hemorrhage 1 (2%)
Skeletal Muscle (2) (3)
Mineralization 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Compression 7 (14%) 4 (8%) 5 (10%) 3 (6%)
Gliosis 1 (2%)
Hemorrhage 4 (8%) 4 (8%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (48) (50)
Foreign Body 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 3 (6%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Epiglottis, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Lung (50) (50) (49) (50)
Hemorrhage 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic 5 (10%) 2 (4%) 5 (10%) 4 (8%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Necrosis, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 2 (4%) 5 (10%) 6 (12%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%) 4 (8%)
Alveolus, Foreign Body 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 11 (22%) 3 (6%) 8 (16%) 8 (16%)
Alveolus, Proteinosis 1 (2%)
Artery, Mineralization 1 (2%)
Artery, Thrombosis 1 (2%)
Interstitium, Fibrosis 5 (10%) 1 (2%) 4 (8%) 6 (12%)
Nose (50) (49) (49) (50)
Foreign Body 6 (12%) 6 (12%) 4 (8%) 3 (6%)
Hemorrhage 1 (2%)
Inflammation, Chronic 4 (8%)
Inflammation, Suppurative 6 (12%) 10 (20%) 11 (22%) 4 (8%)
Glands, Dilatation 1 (2%) 2 (4%) 7 (14%) 15 (30%)
Goblet Cell, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 15 (30%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Degeneration, Hyaline 25 (51%) 45 (92%) 50 (100%)
Olfactory Epithelium, Hyperplasia, Basal Cell 1 (2%)
Respiratory Epithelium, Hyperplasia 2 (4%) 2 (4%) 4 (8%) 3 (6%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Pleura (49) (50) (49) (50)
Inflammation, Chronic 6 (12%) 2 (4%) 3 (6%) 7 (14%)
Mesothelium, Hyperplasia 2 (4%)
Trachea (50) (49) (49) (50)
Glands, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Cyst 1 (100%)
Eye (50) (49) (49) (50)
Atrophy 1 (2%)
Hemorrhage 1 (2%)
Anterior Chamber, Inflammation, Suppurative 1 (2%)
Anterior Chamber, Cornea, Inflammation 1 (2%)
Anterior Chamber, Cornea, Inflammation,
Suppurative 1 (2%)
Cornea, Inflammation, Suppurative 1 (2%)
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URINARY SYSTEM
Kidney (50) (50) (49) (50)
Infarct 1 (2%)
Nephropathy, Chronic 46 (92%) 50 (100%) 49 (100%) 50 (100%)
Pigmentation 1 (2%)
Cortex, Infarct 4 (8%) 2 (4%)
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 1 (2%) 2 (4%) 9 (18%) 17 (34%)
Cortex, Renal Tubule, Hyperplasia 3 (6%) 7 (14%) 19 (38%)
Cortex, Renal Tubule, Necrosis 1 (2%)
Papilla, Mineralization 8 (16%) 28 (57%) 41 (82%)
Pelvis, Dilatation 1 (2%)
Pelvis, Inflammation, Suppurative 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%) 6 (12%) 15 (30%)
Renal Tubule, Mineralization 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 2 (4%)
Urethra (1) (1) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:54
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FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
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URINARY SYSTEM - CONT
Inflammation, Suppurative 1 (50%)
Transitional Epithelium, Hyperplasia 1 (100%) 1 (100%) 2 (100%)
Urinary Bladder (50) (49) (49) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Ulcer 1 (2%)
Transitional Epithelium, Hyperplasia 3 (6%) 1 (2%) 3 (6%) 6 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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