TDMS Study 90004-07 Pathology Tables
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
FINAL#1/RATS
Facility: Battelle Northwest
Chemical CAS #: 57018-52-7
Lock Date: 12/11/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 14 12 20 11
Natural Death 3 4 2 3
Survivors
Terminal Sacrifice 33 34 28 36
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (49) (50) (50) (50)
Hepatocellular Adenoma 1 (2%) 2 (4%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (17) (23) (10) (17)
Carcinoma, Metastatic, Ovary 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Adenoma 2 (4%) 2 (4%) 1 (2%) 4 (8%)
Carcinoma 2 (4%) 1 (2%)
Adrenal Medulla (49) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 2 (4%) 1 (2%)
Islets, Pancreatic (49) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 2 (4%)
Carcinoma 1 (2%)
Pituitary Gland (49) (50) (50) (49)
Adenoma 30 (61%) 36 (72%) 32 (64%) 22 (45%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Thyroid Gland (49) (50) (50) (50)
C-Cell, Adenoma 8 (16%) 2 (4%) 3 (6%) 4 (8%)
C-Cell, Carcinoma 2 (4%)
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NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicular Cell, Adenoma 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 2 (4%) 2 (4%) 1 (2%)
Sarcoma, Metastatic, Vagina 1 (2%)
Ovary (50) (50) (50) (50)
Cystadenocarcinoma 1 (2%) 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Uterus (50) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Polyp Stromal 5 (10%) 7 (14%) 11 (22%) 6 (12%)
Sarcoma Stromal 1 (2%)
Bilateral, Polyp Stromal 1 (2%)
Endometrium, Adenoma 1 (2%)
Vagina (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (5) (3) (3) (6)
Lymph Node, Bronchial (9) (4) (10) (5)
Histiocytic Sarcoma, Metastatic, Skin 1 (20%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (10%)
Lymph Node, Mandibular (1) (2) (2)
Lymph Node, Mesenteric (50) (50) (50) (50)
Lymph Node, Mediastinal (43) (46) (45) (43)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Squamous Cell Carcinoma, Metastatic, Lung 2 (4%)
Spleen (49) (50) (50) (50)
Thymus (45) (50) (50) (48)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50) (50)
Adenoma 2 (4%)
Carcinoma 4 (8%) 4 (8%) 1 (2%) 1 (2%)
Carcinoma, Multiple 1 (2%)
Fibroadenoma 18 (37%) 21 (42%) 17 (34%) 20 (40%)
Fibroadenoma, Multiple 7 (14%) 8 (16%) 4 (8%) 9 (18%)
Sarcoma, Metastatic, Vagina 1 (2%)
Skin (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Eyelid, Neural Crest Tumor 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma, Metastatic,
Vagina 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2)
Fibrous Histiocytoma, Metastatic, Skin 1 (100%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (50%)
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NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Pineal Gland, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Vagina 1 (2%)
Squamous Cell Carcinoma 2 (4%)
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NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Alveolus, Squamous Cell Carcinoma,
Metastatic, Lung 1 (2%)
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SPECIAL SENSES SYSTEM
Zymbal's Gland (42) (44) (43) (46)
Carcinoma 2 (5%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cortex, Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 24 (48%) 24 (48%) 28 (56%) 20 (40%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48 50 45
Total Primary Neoplasms 117 116 109 97
Total Animals with Benign Neoplasms 41 45 42 41
Total Benign Neoplasms 75 82 71 72
Total Animals with Malignant Neoplasms 33 27 32 23
Total Malignant Neoplasms 42 34 37 25
Total Animals with Metastatic Neoplasms 4 1 3 1
Total Metastatic Neoplasm 8 1 6 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 20 15 26 22
Natural Death 3 6 8 6
Survivors
Terminal Sacrifice 27 29 16 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Intestine Large, Colon (49) (48) (46) (48)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (47) (47) (47) (45)
Intestine Small, Ileum (47) (47) (43) (45)
Liver (50) (50) (49) (50)
Cholangiocarcinoma 1 (2%)
Hepatocellular Adenoma 3 (6%) 2 (4%) 6 (12%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (13) (9) (10) (7)
Stomach, Forestomach (50) (50) (49) (50)
Stomach, Glandular (50) (50) (49) (50)
Carcinoma 1 (2%)
Muscularis, Lipoma 1 (2%)
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CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (49) (50)
Aorta, Pulmonary Artery, Sarcoma, Metastatic,
Heart 1 (2%)
Heart (50) (50) (49) (50)
Carcinoma, Metastatic, Lung 1 (2%)
Pericardium, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (50) (50) (49) (50)
Pheochromocytoma Malignant 2 (4%) 2 (4%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 10 (20%) 8 (16%) 8 (16%) 6 (12%)
Bilateral, Pheochromocytoma Benign 2 (4%) 3 (6%) 1 (2%)
Islets, Pancreatic (50) (50) (49) (50)
Adenoma 4 (8%) 4 (8%) 5 (10%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (49) (49) (48) (49)
Carcinoma, Metastatic, Thyroid Gland 2 (4%)
Pituitary Gland (50) (50) (49) (50)
Adenoma 35 (70%) 27 (54%) 26 (53%) 32 (64%)
Thyroid Gland (50) (50) (49) (50)
C-Cell, Adenoma 3 (6%) 3 (6%) 3 (6%) 5 (10%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 3 (6%) 3 (6%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (2) (2)
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GENITAL SYSTEM
Epididymis (50) (50) (49) (50)
Preputial Gland (50) (50) (49) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Prostate (50) (50) (49) (50)
Seminal Vesicle (50) (50) (49) (50)
Testes (50) (50) (49) (50)
Bilateral, Interstitial Cell, Adenoma 29 (58%) 31 (62%) 30 (61%) 32 (64%)
Interstitial Cell, Adenoma 12 (24%) 14 (28%) 10 (20%) 10 (20%)
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Page 8
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Lymph Node (12) (7) (15) (6)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (14%)
Lymph Node, Bronchial (24) (7) (9) (21)
Carcinoma, Metastatic, Lung 1 (5%)
Histiocytic Sarcoma, Metastatic, Skin 1 (14%)
Lymph Node, Mandibular (1) (3) (3) (1)
Carcinoma, Metastatic, Zymbal's Gland 1 (33%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Lymph Node, Mediastinal (38) (41) (46) (45)
Carcinoma, Metastatic, Lung 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Heart 1 (2%)
Spleen (50) (50) (49) (50)
Thymus (47) (46) (46) (47)
Sarcoma, Metastatic, Heart 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Carcinoma 2 (4%) 2 (4%) 1 (2%)
Fibroadenoma 2 (4%) 2 (4%) 3 (6%) 3 (6%)
Skin (50) (50) (49) (50)
Basal Cell Adenoma 1 (2%) 3 (6%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Pinna, Neural Crest Tumor 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 4 (8%) 2 (4%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50)
Mandible, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
Mandible, Osteosarcoma 1 (2%)
Vertebra, Chordoma 1 (2%)
Skeletal Muscle (2) (3)
Carcinoma, Metastatic, Thyroid Gland 1 (50%)
Sarcoma, Metastatic, Skin 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Astrocytoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 2 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Heart 1 (2%)
Pleura (49) (50) (49) (50)
Sarcoma, Metastatic, Heart 1 (2%)
Trachea (50) (49) (49) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (49) (49) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Zymbal's Gland (44) (41) (39) (46)
Carcinoma 1 (2%) 2 (5%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Lipoma 1 (2%)
Sarcoma, Metastatic, Heart 1 (2%)
Stromal Nephroma 1 (2%)
Cortex, Renal Tubule, Adenoma 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Cortex, Renal Tubule, Adenoma, Multiple 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (49) (49) (50)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 33 (66%) 31 (62%) 35 (70%) 27 (54%)
Mesothelioma Malignant 2 (4%) 2 (4%) 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 90004-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 11/14/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 300 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 49 50
Total Primary Neoplasms 154 143 145 162
Total Animals with Benign Neoplasms 50 50 48 49
Total Benign Neoplasms 110 100 98 109
Total Animals with Malignant Neoplasms 35 34 40 40
Total Malignant Neoplasms 44 42 47 53
Total Animals with Metastatic Neoplasms 1 3 2 9
Total Metastatic Neoplasm 1 10 2 18
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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