Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/13002

TDMS Study 90004-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 11/14/01       
EXPERIMENT: 90004 TEST: 07                                                                                     TIME: 10:00:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 57018-52-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 11/14/01       
EXPERIMENT: 90004 TEST: 07                                                                                     TIME: 10:00:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 57018-52-7      
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                            PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 11/14/01       
EXPERIMENT: 90004 TEST: 07                                                                                     TIME: 10:00:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C90004       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 57018-52-7      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF        PROPYLENE GLYCOL MONO-T-BUTYL ETHER                                                                       
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Islets, Pancreatic                     Adenoma                                                                                      
Liver                                  Hepatocellular Adenoma                                                                       
Skin                                   Basal Cell Adenoma                                                                           
Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, malignant or NOS), or Trichoepithelioma                       
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom                                                                                                                 
Testes                                 Adenoma                                                                                      
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Mammary Gland                          Carcinoma or Adenoma                                                                         
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Thyroid Gland: C-Cell                  Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Uterus                                 Polyp Stromal                                                                                
                                       Sarcoma Stromal or Polyp Stromal                                                             
All Organs                             Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 1       
Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |2/49 (4%)    2/50 (4%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      0/40.72     |2/42.54      2/46.42      1/42.02      4/45.37      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.7%         4.3%         2.4%         8.8%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |2/33 (6%)    2/34 (6%)    1/28 (4%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      730 (T)      730 (T)      684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.226      P=0.685N     P=0.558N     P=0.375      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.196      P=0.662N     P=0.504N     P=0.367      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.194      P=0.668N     P=0.495N     P=0.362      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.200      P=0.659N     P=0.520N     P=0.372      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.208      P=0.685N     P=0.558N     P=0.369      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.189      P=0.684N     P=0.492N     P=0.349      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      0/40.72     |0/42.54      2/46.74      0/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    1/34 (3%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          642          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.648      P=0.260      (e)          P=0.517      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.653      P=0.259      (e)          P=0.512      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.648      P=0.254      (e)          P=0.510      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.657      P=0.262      (e)          P=0.513      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.638      P=0.231      (e)          P=0.517      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.636      P=0.253      (e)          P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  8/50 (16%)   11/49 (22%)  7/50 (14%)  |2/49 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     12/42.68     8/44.59      11/38.15     7/40.75     |2/42.65      1/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     28.1%        17.9%        28.8%        17.2%       |4.7%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     9/27 (33%)   3/29 (10%)   3/16 (19%)   5/22 (23%)  |1/33 (3%)    1/34 (3%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     409          621          565          724         |702          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.360N     P=0.190N     P=0.250      P=0.281N    |P=0.204N     P=0.487N     P=0.278N     P=0.225N     | 
|POLY 3             |     P=0.247N     P=0.189N     P=0.570      P=0.173N    |P=0.209N     P=0.471N     P=0.240N     P=0.224N     | 
|POLY 1.5           |     P=0.224N     P=0.204N     P=0.578N     P=0.163N    |P=0.211N     P=0.476N     P=0.234N     P=0.226N     | 
|POLY 6             |     P=0.294N     P=0.167N     P=0.506      P=0.195N    |P=0.206N     P=0.468N     P=0.251N     P=0.223N     | 
|LOGISTIC REGRESSION|     P=0.235N     P=0.208N     P=0.508      P=0.190N    |P=0.208N     P=0.467N     P=0.249N     P=0.224N     | 
|COCH-ARM / FISHERS |     P=0.201N     P=0.227N     P=0.522N     P=0.154N    |P=0.211N     P=0.492N     P=0.242N     P=0.242N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.04      0/43.38      0/36.82      2/40.96     |0/42.54      0/46.42      0/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     4.8%         0.0%         0.0%         4.9%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    1/22 (5%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     656          ---          ---          663         |---          ---          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308      P=0.220N     P=0.324N     P=0.647     |P=0.248      (e)          (e)          P=0.517      | 
|POLY 3             |     P=0.337      P=0.230N     P=0.267N     P=0.685     |P=0.231      (e)          (e)          P=0.512      | 
|POLY 1.5           |     P=0.341      P=0.232N     P=0.254N     P=0.690     |P=0.231      (e)          (e)          P=0.510      | 
|POLY 6             |     P=0.329      P=0.228N     P=0.289N     P=0.674     |P=0.231      (e)          (e)          P=0.513      | 
|LOGISTIC REGRESSION|     P=0.338      P=0.233N     P=0.265N     P=0.688     |(e)          (e)          (e)          P=0.517      | 
|COCH-ARM / FISHERS |     P=0.347      P=0.247N     P=0.253N     P=0.691N    |P=0.229      (e)          (e)          P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  9/50 (18%)   11/49 (22%)  9/50 (18%)  |2/49 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     14/42.96     9/44.59      11/38.15     9/41.00     |2/42.65      1/46.42      0/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     32.6%        20.2%        28.8%        22.0%       |4.7%         2.2%         0.0%         2.2%         | 
|TERMINAL (d)       |     10/27 (37%)  4/29 (14%)   3/16 (19%)   6/22 (27%)  |1/33 (3%)    1/34 (3%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     409          621          565          663         |702          730 (T)      ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.452N     P=0.140N     P=0.386      P=0.318N    |P=0.533N     P=0.487N     P=0.278N     P=0.474N     | 
|POLY 3             |     P=0.321N     P=0.138N     P=0.450N     P=0.195N    |P=0.557N     P=0.471N     P=0.240N     P=0.480N     | 
|POLY 1.5           |     P=0.295N     P=0.151N     P=0.398N     P=0.182N    |P=0.559N     P=0.476N     P=0.234N     P=0.482N     | 
|POLY 6             |     P=0.374N     P=0.121N     P=0.526N     P=0.221N    |P=0.552N     P=0.468N     P=0.251N     P=0.478N     | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.152N     P=0.505N     P=0.206N    |P=0.546N     P=0.467N     P=0.249N     P=0.476N     | 
|COCH-ARM / FISHERS |     P=0.268N     P=0.171N     P=0.343N     P=0.171N    |P=0.560N     P=0.492N     P=0.242N     P=0.492N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/49 (2%)    2/50 (4%)   |2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      2/43.67      1/36.82      2/40.99     |2/42.84      2/46.42      1/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         4.6%         2.7%         4.9%        |4.7%         4.3%         2.4%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    1/16 (6%)    1/22 (5%)   |1/33 (3%)    2/34 (6%)    1/28 (4%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      648          729 (T)      656         |702          730 (T)      730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430      P=0.526      P=0.641      P=0.449     |P=0.145N     P=0.681N     P=0.558N     P=0.225N     | 
|POLY 3             |     P=0.479      P=0.516      P=0.732      P=0.493     |P=0.151N     P=0.665N     P=0.507N     P=0.225N     | 
|POLY 1.5           |     P=0.484      P=0.510      P=0.744      P=0.497     |P=0.153N     P=0.672N     P=0.499N     P=0.228N     | 
|POLY 6             |     P=0.467      P=0.522      P=0.712      P=0.484     |P=0.148N     P=0.661N     P=0.522N     P=0.223N     | 
|LOGISTIC REGRESSION|     P=0.467      P=0.512      P=0.641      P=0.483     |P=0.149N     P=0.661N     P=0.531N     P=0.224N     | 
|COCH-ARM / FISHERS |     P=0.488      P=0.500      P=0.747      P=0.500     |P=0.156N     P=0.691N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/49 (2%)    2/50 (4%)   |3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.00      2/43.67      1/36.82      2/40.99     |3/42.84      2/46.42      1/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     4.8%         4.6%         2.7%         4.9%        |7.0%         4.3%         2.4%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    1/16 (6%)    1/22 (5%)   |2/33 (6%)    2/34 (6%)    1/28 (4%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     668          648          729 (T)      656         |702          730 (T)      730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.551      P=0.665N     P=0.650N     P=0.642     |P=0.095N     P=0.484N     P=0.368N     P=0.110N     | 
|POLY 3             |     P=0.601      P=0.680N     P=0.546N     P=0.686     |P=0.100N     P=0.464N     P=0.312N     P=0.109N     | 
|POLY 1.5           |     P=0.607      P=0.684N     P=0.527N     P=0.690     |P=0.101N     P=0.473N     P=0.304N     P=0.112N     | 
|POLY 6             |     P=0.588      P=0.676N     P=0.576N     P=0.675     |P=0.097N     P=0.459N     P=0.328N     P=0.108N     | 
|LOGISTIC REGRESSION|     P=0.597      P=0.688N     P=0.587N     P=0.687     |P=0.097N     P=0.457N     P=0.341N     P=0.108N     | 
|COCH-ARM / FISHERS |     P=0.614      P=0.691N     P=0.508N     P=0.691N    |P=0.103N     P=0.500N     P=0.309N     P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    5/49 (10%)   0/50 (0%)   |0/49 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/41.84      4/43.39      5/37.75      0/40.72     |0/42.54      1/46.42      1/42.02      2/45.19      | 
|POLY-3 PERCENT (g) |     9.6%         9.2%         13.3%        0.0%        |0.0%         2.2%         2.4%         4.4%         | 
|TERMINAL (d)       |     3/27 (11%)   3/29 (10%)   1/16 (6%)    0/22 (0%)   |0/33 (0%)    1/34 (3%)    1/28 (4%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     712          726          642          ---         |---          730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.075N     P=0.604N     P=0.268      P=0.093N    |P=0.246      P=0.506      P=0.467      P=0.258      | 
|POLY 3             |     P=0.046N*    P=0.624N     P=0.435      P=0.063N    |P=0.224      P=0.517      P=0.498      P=0.251      | 
|POLY 1.5           |     P=0.044N*    P=0.629N     P=0.461      P=0.061N    |P=0.223      P=0.514      P=0.503      P=0.249      | 
|POLY 6             |     P=0.052N     P=0.618N     P=0.397      P=0.067N    |P=0.226      P=0.519      P=0.488      P=0.252      | 
|LOGISTIC REGRESSION|     P=0.052N     P=0.599N     P=0.386      P=0.080N    |(e)          P=0.506      P=0.467      P=0.258      | 
|COCH-ARM / FISHERS |     P=0.043N*    P=0.643N     P=0.487      P=0.059N    |P=0.217      P=0.505      P=0.505      P=0.253      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    6/49 (12%)   1/50 (2%)   |1/49 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/41.84      4/43.39      6/37.75      1/40.72     |1/42.54      1/46.42      1/42.02      2/45.19      | 
|POLY-3 PERCENT (g) |     9.6%         9.2%         15.9%        2.5%        |2.4%         2.2%         2.4%         4.4%         | 
|TERMINAL (d)       |     3/27 (11%)   3/29 (10%)   2/16 (13%)   1/22 (5%)   |1/33 (3%)    1/34 (3%)    1/28 (4%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     712          726          642          729 (T)     |730 (T)      730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.181N     P=0.604N     P=0.156      P=0.247N    |P=0.406      P=0.755N     P=0.725      P=0.530      | 
|POLY 3             |     P=0.124N     P=0.624N     P=0.304      P=0.186N    |P=0.377      P=0.741N     P=0.758      P=0.521      | 
|POLY 1.5           |     P=0.118N     P=0.629N     P=0.330      P=0.182N    |P=0.376      P=0.745N     P=0.757N     P=0.518      | 
|POLY 6             |     P=0.137N     P=0.618N     P=0.268      P=0.196N    |P=0.379      P=0.739N     P=0.748      P=0.523      | 
|LOGISTIC REGRESSION|     P=0.138N     P=0.599N     P=0.246      P=0.224N    |P=0.406      P=0.755N     P=0.725      P=0.530      | 
|COCH-ARM / FISHERS |     P=0.113N     P=0.643N     P=0.357      P=0.181N    |P=0.372      P=0.747N     P=0.747N     P=0.508      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/49 (6%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.04      1/43.38      3/37.04      2/40.89     |0/42.54      0/46.42      0/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         2.3%         8.1%         4.9%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    1/16 (6%)    1/22 (5%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     655          729 (T)      681          683         |---          ---          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.385      P=0.747N     P=0.182      P=0.459     |P=0.248      (e)          (e)          P=0.517      | 
|POLY 3             |     P=0.423      P=0.754N     P=0.260      P=0.490     |P=0.231      (e)          (e)          P=0.512      | 
|POLY 1.5           |     P=0.435      P=0.756N     P=0.279      P=0.496     |P=0.231      (e)          (e)          P=0.510      | 
|POLY 6             |     P=0.402      P=0.753N     P=0.233      P=0.478     |P=0.231      (e)          (e)          P=0.513      | 
|LOGISTIC REGRESSION|     P=0.423      P=0.759N     P=0.245      P=0.495     |(e)          (e)          (e)          P=0.517      | 
|COCH-ARM / FISHERS |     P=0.447      P=0.753N     P=0.301      P=0.500     |P=0.229      (e)          (e)          P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/49 (6%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.04      1/43.38      3/37.04      3/40.89     |0/42.54      0/46.42      0/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         2.3%         8.1%         7.3%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    1/16 (6%)    2/22 (9%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     655          729 (T)      681          683         |---          ---          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183      P=0.747N     P=0.182      P=0.259     |P=0.248      (e)          (e)          P=0.517      | 
|POLY 3             |     P=0.214      P=0.754N     P=0.260      P=0.295     |P=0.231      (e)          (e)          P=0.512      | 
|POLY 1.5           |     P=0.223      P=0.756N     P=0.279      P=0.301     |P=0.231      (e)          (e)          P=0.510      | 
|POLY 6             |     P=0.198      P=0.753N     P=0.233      P=0.282     |P=0.231      (e)          (e)          P=0.513      | 
|LOGISTIC REGRESSION|     P=0.209      P=0.759N     P=0.245      P=0.293     |(e)          (e)          (e)          P=0.517      | 
|COCH-ARM / FISHERS |     P=0.232      P=0.753N     P=0.301      P=0.309     |P=0.229      (e)          (e)          P=0.505      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/49 (4%)    6/50 (12%)  |1/49 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/41.84      0/43.38      2/37.00      6/41.90     |1/42.54      0/46.42      0/42.02      2/45.21      | 
|POLY-3 PERCENT (g) |     7.2%         0.0%         5.4%         14.3%       |2.4%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     2/27 (7%)    0/29 (0%)    1/16 (6%)    2/22 (9%)   |1/33 (3%)    0/34 (0%)    0/28 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     712          ---          684          537         |730 (T)      ---          ---          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.113N     P=0.654      P=0.183     |P=0.204      P=0.494N     P=0.533N     P=0.533      | 
|POLY 3             |     P=0.022 *    P=0.112N     P=0.556N     P=0.241     |P=0.176      P=0.483N     P=0.502N     P=0.521      | 
|POLY 1.5           |     P=0.023 *    P=0.114N     P=0.533N     P=0.243     |P=0.176      P=0.486N     P=0.497N     P=0.518      | 
|POLY 6             |     P=0.021 *    P=0.109N     P=0.592N     P=0.233     |P=0.177      P=0.481N     P=0.512N     P=0.524      | 
|LOGISTIC REGRESSION|     P=0.023 *    P=0.106N     P=0.644N     P=0.235     |P=0.197      (e)          (e)          P=0.532      | 
|COCH-ARM / FISHERS |     P=0.026 *    P=0.121N     P=0.510N     P=0.243     |P=0.177      P=0.495N     P=0.495N     P=0.508      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      0/43.38      1/36.95      2/41.10     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.7%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          697          662         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.203      P=0.486N     P=0.656      P=0.457     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.229      P=0.492N     P=0.733      P=0.494     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.234      P=0.495N     P=0.745      P=0.498     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.220      P=0.490N     P=0.714      P=0.486     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.231      (e)          P=0.701      P=0.491     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.239      P=0.500N     P=0.747      P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      0/43.38      1/36.95      3/41.10     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.7%         7.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    1/22 (5%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          697          662         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.062      P=0.486N     P=0.656      P=0.258     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.075      P=0.492N     P=0.733      P=0.299     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.078      P=0.495N     P=0.745      P=0.303     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.071      P=0.490N     P=0.714      P=0.290     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.074      (e)          P=0.701      P=0.287     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.081      P=0.500N     P=0.747      P=0.309     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      0/40.72     |0/42.73      0/46.42      2/43.15      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          471          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.647N     (e)          P=0.246      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.648N     (e)          P=0.239      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.649N     (e)          P=0.242      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.648N     (e)          P=0.233      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.708N     (e)          P=0.141      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.652N     (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      0/43.38      0/36.82      0/40.72     |0/42.73      2/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    2/34 (6%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.373N     P=0.245      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.366N     P=0.256      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.373N     P=0.251      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.358N     P=0.259      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.245      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.390N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |5/50 (10%)   4/50 (8%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      2/43.69      2/37.46      1/40.84     |5/42.73      4/46.87      1/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         5.3%         2.5%        |11.7%        8.5%         2.4%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    0/22 (0%)   |5/33 (15%)   2/34 (6%)    1/28 (4%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          642          593          698         |730 (T)      656          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.627      P=0.256      P=0.191      P=0.465     |P=0.077N     P=0.473N     P=0.142N     P=0.083N     | 
|POLY 3             |     P=0.658      P=0.247      P=0.213      P=0.495     |P=0.083N     P=0.442N     P=0.104N     P=0.089N     | 
|POLY 1.5           |     P=0.661N     P=0.244      P=0.223      P=0.498     |P=0.085N     P=0.458N     P=0.100N     P=0.092N     | 
|POLY 6             |     P=0.643      P=0.251      P=0.199      P=0.490     |P=0.081N     P=0.429N     P=0.114N     P=0.086N     | 
|LOGISTIC REGRESSION|     P=0.659N     P=0.238      P=0.246      P=0.494     |P=0.083N     P=0.446N     P=0.142N     P=0.083N     | 
|COCH-ARM / FISHERS |     P=0.658N     P=0.247      P=0.247      P=0.500     |P=0.089N     P=0.500N     P=0.102N     P=0.102N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |5/50 (10%)   6/50 (12%)   1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/41.77      2/43.69      2/37.46      1/40.84     |5/42.73      6/46.87      1/42.02      1/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         5.3%         2.5%        |11.7%        12.8%        2.4%         2.2%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    0/22 (0%)   |5/33 (15%)   4/34 (12%)   1/28 (4%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          642          593          698         |730 (T)      656          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.627      P=0.256      P=0.191      P=0.465     |P=0.044N*    P=0.529      P=0.142N     P=0.083N     | 
|POLY 3             |     P=0.658      P=0.247      P=0.213      P=0.495     |P=0.045N*    P=0.565      P=0.104N     P=0.089N     | 
|POLY 1.5           |     P=0.661N     P=0.244      P=0.223      P=0.498     |P=0.046N*    P=0.546      P=0.100N     P=0.092N     | 
|POLY 6             |     P=0.643      P=0.251      P=0.199      P=0.490     |P=0.042N*    P=0.579      P=0.114N     P=0.086N     | 
|LOGISTIC REGRESSION|     P=0.659N     P=0.238      P=0.246      P=0.494     |P=0.047N*    P=0.565      P=0.142N     P=0.083N     | 
|COCH-ARM / FISHERS |     P=0.658N     P=0.247      P=0.247      P=0.500     |P=0.052N     P=0.500      P=0.102N     P=0.102N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    3/50 (6%)   |25/50 (50%)  29/50 (58%)  21/50 (42%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     2/41.77      2/43.69      3/37.52      3/41.24     |25/43.37     29/47.72     21/43.87     29/46.02     | 
|POLY-3 PERCENT (g) |     4.8%         4.6%         8.0%         7.3%        |57.7%        60.8%        47.9%        63.0%        | 
|TERMINAL (d)       |     2/27 (7%)    1/29 (3%)    1/16 (6%)    1/22 (5%)   |23/33 (70%)  21/34 (62%)  12/28 (43%)  23/36 (64%)  | 
|FIRST INCIDENCE    |     729 (T)      642          621          656         |558          642          610          642          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.364      P=0.668N     P=0.320      P=0.439     |P=0.496      P=0.357      P=0.528N     P=0.446      | 
|POLY 3             |     P=0.413      P=0.678N     P=0.451      P=0.494     |P=0.321      P=0.464      P=0.236N     P=0.378      | 
|POLY 1.5           |     P=0.422      P=0.683N     P=0.471      P=0.498     |P=0.312      P=0.402      P=0.233N     P=0.347      | 
|POLY 6             |     P=0.397      P=0.671N     P=0.421      P=0.485     |P=0.334      P=0.526      P=0.249N     P=0.414      | 
|LOGISTIC REGRESSION|     P=0.421      P=0.680N     P=0.442      P=0.483     |P=0.348      P=0.473      P=0.343N     P=0.396      | 
|COCH-ARM / FISHERS |     P=0.429      P=0.691N     P=0.500      P=0.500     |P=0.290      P=0.274      P=0.274N     P=0.274      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    3/50 (6%)   |25/50 (50%)  30/50 (60%)  21/50 (42%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     2/41.77      2/43.69      3/37.52      3/41.24     |25/43.37     30/47.72     21/43.87     29/46.02     | 
|POLY-3 PERCENT (g) |     4.8%         4.6%         8.0%         7.3%        |57.7%        62.9%        47.9%        63.0%        | 
|TERMINAL (d)       |     2/27 (7%)    1/29 (3%)    1/16 (6%)    1/22 (5%)   |23/33 (70%)  22/34 (65%)  12/28 (43%)  23/36 (64%)  | 
|FIRST INCIDENCE    |     729 (T)      642          621          656         |558          642          610          642          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.364      P=0.668N     P=0.320      P=0.439     |P=0.532      P=0.285      P=0.528N     P=0.446      | 
|POLY 3             |     P=0.413      P=0.678N     P=0.451      P=0.494     |P=0.360      P=0.382      P=0.236N     P=0.378      | 
|POLY 1.5           |     P=0.422      P=0.683N     P=0.471      P=0.498     |P=0.349      P=0.325      P=0.233N     P=0.347      | 
|POLY 6             |     P=0.397      P=0.671N     P=0.421      P=0.485     |P=0.376      P=0.442      P=0.249N     P=0.414      | 
|LOGISTIC REGRESSION|     P=0.421      P=0.680N     P=0.442      P=0.483     |P=0.386      P=0.394      P=0.343N     P=0.396      | 
|COCH-ARM / FISHERS |     P=0.429      P=0.691N     P=0.500      P=0.500     |P=0.323      P=0.211      P=0.274N     P=0.274      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    5/50 (10%)   4/50 (8%)   |27/50 (54%)  32/50 (64%)  21/50 (42%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     2/41.77      3/43.69      5/38.16      4/41.36     |27/43.37     32/47.90     21/43.87     29/46.02     | 
|POLY-3 PERCENT (g) |     4.8%         6.9%         13.1%        9.7%        |62.3%        66.8%        47.9%        63.0%        | 
|TERMINAL (d)       |     2/27 (7%)    2/29 (7%)    1/16 (6%)    1/22 (5%)   |25/33 (76%)  23/34 (68%)  12/28 (43%)  23/36 (64%)  | 
|FIRST INCIDENCE    |     729 (T)      642          593          656         |558          642          610          642          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.301      P=0.533      P=0.104      P=0.278     |P=0.405N     P=0.289      P=0.385N     P=0.547N     | 
|POLY 3             |     P=0.354      P=0.521      P=0.179      P=0.332     |P=0.540      P=0.405      P=0.120N     P=0.559      | 
|POLY 1.5           |     P=0.363      P=0.514      P=0.193      P=0.336     |P=0.524      P=0.337      P=0.121N     P=0.518      | 
|POLY 6             |     P=0.336      P=0.529      P=0.159      P=0.323     |P=0.559      P=0.482      P=0.125N     P=0.580N     | 
|LOGISTIC REGRESSION|     P=0.365      P=0.523      P=0.190      P=0.319     |P=0.548N     P=0.411      P=0.206N     P=0.579      | 
|COCH-ARM / FISHERS |     P=0.372      P=0.500      P=0.218      P=0.339     |P=0.484      P=0.208      P=0.158N     P=0.420      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  27/50 (54%)  26/49 (53%)  32/50 (64%) |30/49 (61%)  36/50 (72%)  32/50 (64%)  22/49 (45%)  | 
|POLY-3 RATE (b)    |     35/46.77     27/46.42     26/42.14     32/45.38    |30/44.48     36/49.68     32/45.65     22/46.71     | 
|POLY-3 PERCENT (g) |     74.8%        58.2%        61.7%        70.5%       |67.4%        72.5%        70.1%        47.1%        | 
|TERMINAL (d)       |     21/27 (78%)  16/29 (55%)  9/16 (56%)   15/22 (68%) |23/33 (70%)  21/34 (62%)  20/28 (71%)  15/36 (42%)  | 
|FIRST INCIDENCE    |     296          509          431          518         |537          410          528          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.193      P=0.070N     P=0.406      P=0.456     |P=0.008N**   P=0.294      P=0.176      P=0.051N     | 
|POLY 3             |     P=0.382      P=0.060N     P=0.121N     P=0.404N    |P=0.003N**   P=0.379      P=0.482      P=0.036N*    | 
|POLY 1.5           |     P=0.401      P=0.064N     P=0.089N     P=0.378N    |P=0.004N**   P=0.312      P=0.506      P=0.043N*    | 
|POLY 6             |     P=0.357      P=0.060N     P=0.182N     P=0.444N    |P=0.003N**   P=0.450      P=0.438      P=0.031N*    | 
|LOGISTIC REGRESSION|     P=0.412      P=0.063N     P=0.091N     P=0.345N    |P=0.005N**   P=0.256      P=0.424      P=0.043N*    | 
|COCH-ARM / FISHERS |     P=0.444      P=0.074N     P=0.063N     P=0.335N    |P=0.008N**   P=0.178      P=0.469      P=0.078N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      1/43.38      0/36.82      3/40.84     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         7.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    2/22 (9%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          698         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    P=0.514      (e)          P=0.090     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.038 *    P=0.508      (e)          P=0.114     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.039 *    P=0.505      (e)          P=0.117     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.037 *    P=0.510      (e)          P=0.108     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.032 *    P=0.514      (e)          P=0.100     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.041 *    P=0.500      (e)          P=0.121     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.77      1/43.38      0/36.82      4/40.86     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         9.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    2/22 (9%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          698         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.007 **   P=0.514      (e)          P=0.045 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.009 **   P=0.508      (e)          P=0.057     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.009 **   P=0.505      (e)          P=0.059     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.008 **   P=0.510      (e)          P=0.053     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.007 **   P=0.514      (e)          P=0.047 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.010 *    P=0.500      (e)          P=0.059     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.12      1/43.38      1/36.88      5/41.10     |0/42.73      0/46.42      0/42.02      1/45.42      | 
|POLY-3 PERCENT (g) |     4.8%         2.3%         2.7%         12.2%       |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    0/16 (0%)    2/22 (9%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     631          729 (T)      716          666         |---          ---          ---          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032 *    P=0.481N     P=0.635N     P=0.168     |P=0.241      (e)          (e)          P=0.514      | 
|POLY 3             |     P=0.040 *    P=0.490N     P=0.546N     P=0.205     |P=0.231      (e)          (e)          P=0.512      | 
|POLY 1.5           |     P=0.042 *    P=0.492N     P=0.527N     P=0.211     |P=0.231      (e)          (e)          P=0.509      | 
|POLY 6             |     P=0.037 *    P=0.487N     P=0.577N     P=0.192     |P=0.232      (e)          (e)          P=0.515      | 
|LOGISTIC REGRESSION|     P=0.038 *    P=0.491N     P=0.548N     P=0.200     |P=0.222      (e)          (e)          P=0.492      | 
|COCH-ARM / FISHERS |     P=0.045 *    P=0.500N     P=0.500N     P=0.218     |P=0.228      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    2/50 (4%)    4/50 (8%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/41.84      4/44.26      2/36.95      4/40.99     |1/42.95      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     4.8%         9.0%         5.4%         9.8%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    2/29 (7%)    1/16 (6%)    3/22 (14%)  |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     712          513          697          655         |670          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.290      P=0.369      P=0.512      P=0.259     |P=0.541N     P=0.486N     P=0.521N     P=0.490N     | 
|POLY 3             |     P=0.359      P=0.363      P=0.649      P=0.327     |P=0.553N     P=0.485N     P=0.504N     P=0.490N     | 
|POLY 1.5           |     P=0.367      P=0.354      P=0.668      P=0.333     |P=0.553N     P=0.488N     P=0.500N     P=0.492N     | 
|POLY 6             |     P=0.341      P=0.374      P=0.618      P=0.313     |P=0.551N     P=0.483N     P=0.514N     P=0.489N     | 
|LOGISTIC REGRESSION|     P=0.355      P=0.334      P=0.578      P=0.296     |P=0.552N     P=0.518N     P=0.501N     P=0.508N     | 
|COCH-ARM / FISHERS |     P=0.372      P=0.339      P=0.691N     P=0.339     |P=0.547N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    2/50 (4%)    5/50 (10%)  |3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/41.84      4/44.26      2/36.95      5/41.32     |3/43.12      0/46.42      0/42.02      1/45.37      | 
|POLY-3 PERCENT (g) |     7.2%         9.0%         5.4%         12.1%       |7.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     2/27 (7%)    2/29 (7%)    1/16 (6%)    3/22 (14%)  |1/33 (3%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     712          513          697          639         |670          ---          ---          684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.218      P=0.534      P=0.646      P=0.270     |P=0.513N     P=0.117N     P=0.148N     P=0.290N     | 
|POLY 3             |     P=0.283      P=0.531      P=0.557N     P=0.348     |P=0.540N     P=0.106N     P=0.123N     P=0.287N     | 
|POLY 1.5           |     P=0.290      P=0.520      P=0.533N     P=0.354     |P=0.540N     P=0.109N     P=0.119N     P=0.291N     | 
|POLY 6             |     P=0.269      P=0.544      P=0.593N     P=0.336     |P=0.535N     P=0.105N     P=0.132N     P=0.285N     | 
|LOGISTIC REGRESSION|     P=0.279      P=0.505      P=0.655N     P=0.325     |P=0.531N     P=0.115N     P=0.121N     P=0.299N     | 
|COCH-ARM / FISHERS |     P=0.294      P=0.500      P=0.500N     P=0.357     |P=0.532N     P=0.121N     P=0.121N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.77      0/43.38      0/36.82      1/41.04     |2/42.89      0/46.42      0/42.02      1/45.37      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         2.4%        |4.7%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |1/33 (3%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          639         |687          ---          ---          684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491      P=0.486N     P=0.604N     P=0.729     |P=0.694N     P=0.234N     P=0.270N     P=0.481N     | 
|POLY 3             |     P=0.514      P=0.492N     P=0.525N     P=0.757     |P=0.695      P=0.220N     P=0.242N     P=0.480N     | 
|POLY 1.5           |     P=0.517      P=0.495N     P=0.515N     P=0.759     |P=0.695      P=0.224N     P=0.236N     P=0.485N     | 
|POLY 6             |     P=0.506      P=0.490N     P=0.542N     P=0.752     |P=0.696      P=0.218N     P=0.252N     P=0.477N     | 
|LOGISTIC REGRESSION|     P=0.519      (e)          (e)          P=0.761     |P=0.702      P=0.223N     P=0.243N     P=0.490N     | 
|COCH-ARM / FISHERS |     P=0.522      P=0.500N     P=0.500N     P=0.753N    |P=0.700      P=0.247N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Lipoma                                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/41.77      2/43.47      1/36.82      0/40.72     |0/42.73      0/46.42      1/42.25      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         4.6%         2.7%         0.0%        |0.0%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    1/16 (6%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      705          729 (T)      ---         |---          ---          670          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.293N     P=0.527      P=0.641      P=0.541N    |P=0.764N     (e)          P=0.479      (e)          | 
|POLY 3             |     P=0.241N     P=0.514      P=0.732      P=0.505N    |P=0.770N     (e)          P=0.498      (e)          | 
|POLY 1.5           |     P=0.239N     P=0.509      P=0.744      P=0.502N    |P=0.770N     (e)          P=0.502      (e)          | 
|POLY 6             |     P=0.247N     P=0.519      P=0.712      P=0.512N    |P=0.769N     (e)          P=0.490      (e)          | 
|LOGISTIC REGRESSION|     P=0.274N     P=0.525      P=0.641      (e)         |P=0.777N     (e)          P=0.499      (e)          | 
|COCH-ARM / FISHERS |     P=0.238N     P=0.500      P=0.753N     P=0.500N    |P=0.772N     (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.12      0/43.38      1/36.88      1/40.95     |0/42.73      0/46.42      0/42.02      1/45.42      | 
|POLY-3 PERCENT (g) |     4.8%         0.0%         2.7%         2.4%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     631          ---          716          666         |---          ---          ---          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.674      P=0.229N     P=0.635N     P=0.537N    |P=0.241      (e)          (e)          P=0.514      | 
|POLY 3             |     P=0.662N     P=0.230N     P=0.546N     P=0.510N    |P=0.231      (e)          (e)          P=0.512      | 
|POLY 1.5           |     P=0.658N     P=0.232N     P=0.527N     P=0.504N    |P=0.231      (e)          (e)          P=0.509      | 
|POLY 6             |     P=0.670N     P=0.229N     P=0.577N     P=0.522N    |P=0.232      (e)          (e)          P=0.515      | 
|LOGISTIC REGRESSION|     P=0.658N     P=0.238N     P=0.548N     P=0.500N    |P=0.222      (e)          (e)          P=0.492      | 
|COCH-ARM / FISHERS |     P=0.654N     P=0.247N     P=0.500N     P=0.500N    |P=0.228      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.12      0/43.38      1/36.88      1/40.95     |0/42.73      0/46.42      0/42.02      1/45.42      | 
|POLY-3 PERCENT (g) |     4.8%         0.0%         2.7%         2.4%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     631          ---          716          666         |---          ---          ---          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.674      P=0.229N     P=0.635N     P=0.537N    |P=0.241      (e)          (e)          P=0.514      | 
|POLY 3             |     P=0.662N     P=0.230N     P=0.546N     P=0.510N    |P=0.231      (e)          (e)          P=0.512      | 
|POLY 1.5           |     P=0.658N     P=0.232N     P=0.527N     P=0.504N    |P=0.231      (e)          (e)          P=0.509      | 
|POLY 6             |     P=0.670N     P=0.229N     P=0.577N     P=0.522N    |P=0.232      (e)          (e)          P=0.515      | 
|LOGISTIC REGRESSION|     P=0.658N     P=0.238N     P=0.548N     P=0.500N    |P=0.222      (e)          (e)          P=0.492      | 
|COCH-ARM / FISHERS |     P=0.654N     P=0.247N     P=0.500N     P=0.500N    |P=0.228      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  45/50 (90%)  40/49 (82%)  42/50 (84%) |                                                    | 
|POLY-3 RATE (b)    |     41/45.93     45/48.37     40/45.72     42/46.78    |                                                    | 
|POLY-3 PERCENT (g) |     89.3%        93.0%        87.5%        89.8%       |                                                    | 
|TERMINAL (d)       |     25/27 (93%)  28/29 (97%)  16/16 (100%) 22/22 (100%)|                                                    | 
|FIRST INCIDENCE    |     458          464          431          509         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187      P=0.498      P=0.020 *    P=0.158     |                                                    | 
|POLY 3             |     P=0.529N     P=0.377      P=0.527N     P=0.616     |                                                    | 
|POLY 1.5           |     P=0.510N     P=0.298      P=0.532N     P=0.576     |                                                    | 
|POLY 6             |     P=0.615N     P=0.474      P=0.580N     P=0.617     |                                                    | 
|LOGISTIC REGRESSION|     P=0.530N     P=0.286      P=0.467      P=0.504     |                                                    | 
|COCH-ARM / FISHERS |     P=0.499N     P=0.194      P=0.584N     P=0.500     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    3/49 (6%)    5/50 (10%)  |8/49 (16%)   2/50 (4%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     3/41.90      4/43.50      3/37.30      5/40.74     |8/43.38      2/46.43      3/42.48      4/45.42      | 
|POLY-3 PERCENT (g) |     7.2%         9.2%         8.0%         12.3%       |18.4%        4.3%         7.1%         8.8%         | 
|TERMINAL (d)       |     1/27 (4%)    3/29 (10%)   1/16 (6%)    4/22 (18%)  |5/33 (15%)   1/34 (3%)    2/28 (7%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     712          697          634          724         |537          726          593          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.224      P=0.536      P=0.455      P=0.257     |P=0.367N     P=0.046N*    P=0.156N     P=0.148N     | 
|POLY 3             |     P=0.299      P=0.520      P=0.608      P=0.340     |P=0.411N     P=0.034N*    P=0.103N     P=0.154N     | 
|POLY 1.5           |     P=0.310      P=0.514      P=0.631      P=0.350     |P=0.412N     P=0.036N*    P=0.095N     P=0.156N     | 
|POLY 6             |     P=0.276      P=0.527      P=0.572      P=0.319     |P=0.404N     P=0.034N*    P=0.119N     P=0.153N     | 
|LOGISTIC REGRESSION|     P=0.260      P=0.537      P=0.571      P=0.275     |P=0.404N     P=0.039N*    P=0.096N     P=0.156N     | 
|COCH-ARM / FISHERS |     P=0.320      P=0.500      P=0.651      P=0.357     |P=0.410N     P=0.043N*    P=0.094N     P=0.168N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/49 (6%)    3/50 (6%)   |2/49 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.00      1/43.76      3/38.07      3/40.90     |2/43.01      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         2.3%         7.9%         7.3%        |4.7%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    2/22 (9%)   |1/33 (3%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     668          621          509          681         |593          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.200      P=0.751N     P=0.241      P=0.254     |P=0.303N     P=0.222N     P=0.258N     P=0.225N     | 
|POLY 3             |     P=0.213      P=0.752N     P=0.270      P=0.295     |P=0.310N     P=0.220N     P=0.242N     P=0.226N     | 
|POLY 1.5           |     P=0.222      P=0.754N     P=0.284      P=0.301     |P=0.311N     P=0.223N     P=0.235N     P=0.227N     | 
|POLY 6             |     P=0.196      P=0.749N     P=0.247      P=0.283     |P=0.307N     P=0.220N     P=0.254N     P=0.226N     | 
|LOGISTIC REGRESSION|     P=0.238      P=0.745      P=0.324      P=0.290     |P=0.311N     P=0.253N     P=0.236N     P=0.243N     | 
|COCH-ARM / FISHERS |     P=0.232      P=0.753N     P=0.301      P=0.309     |P=0.306N     P=0.242N     P=0.242N     P=0.242N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   6/49 (12%)   7/50 (14%)  |9/49 (18%)   2/50 (4%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/42.14      5/43.88      6/38.54      7/40.92     |9/43.85      2/46.43      3/42.48      4/45.42      | 
|POLY-3 PERCENT (g) |     9.5%         11.4%        15.6%        17.1%       |20.5%        4.3%         7.1%         8.8%         | 
|TERMINAL (d)       |     1/27 (4%)    3/29 (10%)   1/16 (6%)    5/22 (23%)  |5/33 (15%)   1/34 (3%)    2/28 (7%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     668          621          509          681         |537          726          593          669          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.168      P=0.537      P=0.195      P=0.175     |P=0.300N     P=0.026N*    P=0.103N     P=0.098N     | 
|POLY 3             |     P=0.216      P=0.526      P=0.313      P=0.241     |P=0.335N     P=0.019N*    P=0.065N     P=0.101N     | 
|POLY 1.5           |     P=0.232      P=0.517      P=0.335      P=0.253     |P=0.337N     P=0.020N*    P=0.058N     P=0.101N     | 
|POLY 6             |     P=0.189      P=0.534      P=0.277      P=0.219     |P=0.329N     P=0.019N*    P=0.079N     P=0.102N     | 
|LOGISTIC REGRESSION|     P=0.230      P=0.523      P=0.350      P=0.205     |P=0.333N     P=0.024N*    P=0.057N     P=0.105N     | 
|COCH-ARM / FISHERS |     P=0.247      P=0.500      P=0.357      P=0.262     |P=0.335N     P=0.023N*    P=0.056N     P=0.109N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/49 (0%)    2/50 (4%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.04      1/43.47      0/36.82      2/41.38     |0/42.54      1/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         2.3%         0.0%         4.8%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/16 (0%)    0/22 (0%)   |0/33 (0%)    1/34 (3%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     656          705          ---          582         |---          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.289      P=0.738N     P=0.545N     P=0.481     |P=0.589N     P=0.506      (e)          (e)          | 
|POLY 3             |     P=0.316      P=0.753N     P=0.526N     P=0.494     |P=0.591N     P=0.517      (e)          (e)          | 
|POLY 1.5           |     P=0.318      P=0.755N     P=0.515N     P=0.498     |P=0.596N     P=0.514      (e)          (e)          | 
|POLY 6             |     P=0.310      P=0.751N     P=0.544N     P=0.486     |P=0.586N     P=0.519      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.322      P=0.763      P=0.500N     P=0.502     |(e)          P=0.506      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.318      P=0.753N     P=0.505N     P=0.500     |P=0.607N     P=0.505      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   7/50 (14%)   12/50 (24%)  6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |5/42.73      7/46.42      12/43.19     6/45.77      | 
|POLY-3 PERCENT (g) |                                                        |11.7%        15.1%        27.8%        13.1%        | 
|TERMINAL (d)       |                                                        |5/33 (15%)   7/34 (21%)   8/28 (29%)   4/36 (11%)   | 
|FIRST INCIDENCE    |                                                        |730 (T)      730 (T)      559          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.413N     P=0.398      P=0.029 *    P=0.559      | 
|POLY 3             |                                                        |P=0.453N     P=0.438      P=0.052      P=0.548      | 
|POLY 1.5           |                                                        |P=0.466N     P=0.423      P=0.056      P=0.535      | 
|POLY 6             |                                                        |P=0.438N     P=0.447      P=0.045 *    P=0.560      | 
|LOGISTIC REGRESSION|                                                        |P=0.468N     P=0.398      P=0.044 *    P=0.539      | 
|COCH-ARM / FISHERS |                                                        |P=0.494N     P=0.380      P=0.054      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   7/50 (14%)   12/50 (24%)  6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |5/42.73      7/46.42      12/43.19     6/45.77      | 
|POLY-3 PERCENT (g) |                                                        |11.7%        15.1%        27.8%        13.1%        | 
|TERMINAL (d)       |                                                        |5/33 (15%)   7/34 (21%)   8/28 (29%)   4/36 (11%)   | 
|FIRST INCIDENCE    |                                                        |730 (T)      730 (T)      559          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.413N     P=0.398      P=0.029 *    P=0.559      | 
|POLY 3             |                                                        |P=0.453N     P=0.438      P=0.052      P=0.548      | 
|POLY 1.5           |                                                        |P=0.466N     P=0.423      P=0.056      P=0.535      | 
|POLY 6             |                                                        |P=0.438N     P=0.447      P=0.045 *    P=0.560      | 
|LOGISTIC REGRESSION|                                                        |P=0.468N     P=0.398      P=0.044 *    P=0.539      | 
|COCH-ARM / FISHERS |                                                        |P=0.494N     P=0.380      P=0.054      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.52      2/44.12      0/36.82      2/40.72     |2/44.48      1/46.42      1/42.44      0/45.19      | 
|POLY-3 PERCENT (g) |     2.4%         4.5%         0.0%         4.9%        |4.5%         2.2%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    1/29 (3%)    0/16 (0%)    2/22 (9%)   |0/33 (0%)    1/34 (3%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     458          464          ---          729 (T)     |284          730 (T)      610          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.410      P=0.520      P=0.504N     P=0.455     |P=0.212N     P=0.489N     P=0.491N     P=0.235N     | 
|POLY 3             |     P=0.441      P=0.513      P=0.529N     P=0.485     |P=0.215N     P=0.485N     P=0.516N     P=0.234N     | 
|POLY 1.5           |     P=0.447      P=0.509      P=0.517N     P=0.492     |P=0.216N     P=0.489N     P=0.507N     P=0.234N     | 
|POLY 6             |     P=0.429      P=0.517      P=0.546N     P=0.471     |P=0.213N     P=0.483N     P=0.531N     P=0.233N     | 
|LOGISTIC REGRESSION|     P=0.454      P=0.342      P=0.391N     P=0.502     |P=0.267N     P=0.706      P=0.735      P=0.442N     | 
|COCH-ARM / FISHERS |     P=0.451      P=0.500      P=0.500N     P=0.500     |P=0.214N     P=0.500N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  31/50 (62%)  35/50 (70%)  27/50 (54%) |24/50 (48%)  24/50 (48%)  28/50 (56%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     33/47.19     31/46.27     35/45.61     27/45.69    |24/45.04     24/47.68     28/47.24     20/47.78     | 
|POLY-3 PERCENT (g) |     69.9%        67.0%        76.7%        59.1%       |53.3%        50.3%        59.3%        41.9%        | 
|TERMINAL (d)       |     16/27 (59%)  19/29 (66%)  12/16 (75%)  13/22 (59%) |15/33 (46%)  17/34 (50%)  13/28 (46%)  13/36 (36%)  | 
|FIRST INCIDENCE    |     296          569          361          254         |380          642          507          519          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.437N     P=0.317N     P=0.034 *    P=0.443N    |P=0.133N     P=0.490N     P=0.163      P=0.205N     | 
|POLY 3             |     P=0.121N     P=0.466N     P=0.300      P=0.183N    |P=0.123N     P=0.469N     P=0.354      P=0.184N     | 
|POLY 1.5           |     P=0.108N     P=0.444N     P=0.329      P=0.162N    |P=0.139N     P=0.494N     P=0.340      P=0.207N     | 
|POLY 6             |     P=0.169N     P=0.496N     P=0.248      P=0.241N    |P=0.109N     P=0.459N     P=0.357      P=0.167N     | 
|LOGISTIC REGRESSION|     P=0.118N     P=0.381N     P=0.368      P=0.153N    |P=0.170N     P=0.468N     P=0.281      P=0.245N     | 
|COCH-ARM / FISHERS |     P=0.114N     P=0.418N     P=0.415      P=0.154N    |P=0.176N     P=0.579N     P=0.274      P=0.273N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.09      2/44.04      3/37.84      4/41.21     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     4.8%         4.5%         7.9%         9.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    1/16 (6%)    2/22 (9%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     639          509          561          662         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      P=0.670N     P=0.368      P=0.283     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.227      P=0.678N     P=0.451      P=0.327     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.236      P=0.683N     P=0.471      P=0.333     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.212      P=0.673N     P=0.420      P=0.313     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.245      P=0.671      P=0.510      P=0.328     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.244      P=0.691N     P=0.500      P=0.339     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.09      2/44.04      3/37.84      4/41.21     |0/42.73      0/46.42      0/42.02      0/45.19      | 
|POLY-3 PERCENT (g) |     4.8%         4.5%         7.9%         9.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    1/16 (6%)    2/22 (9%)   |0/33 (0%)    0/34 (0%)    0/28 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     639          509          561          662         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      P=0.670N     P=0.368      P=0.283     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.227      P=0.678N     P=0.451      P=0.327     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.236      P=0.683N     P=0.471      P=0.333     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.212      P=0.673N     P=0.420      P=0.313     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.245      P=0.671      P=0.510      P=0.328     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.244      P=0.691N     P=0.500      P=0.339     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 48/50 (96%)  49/50 (98%) |41/50 (82%)  45/50 (90%)  42/50 (84%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     48/48.12     49/49.04    |41/45.13     45/50.00     42/46.79     41/47.85     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       99.8%        99.9%       |90.8%        90.0%        89.8%        85.7%        | 
|TERMINAL (d)       |     27/27 (100%) 29/29 (100%) 16/16 (100%) 22/22 (100%)|31/33 (94%)  29/34 (85%)  26/28 (93%)  30/36 (83%)  | 
|FIRST INCIDENCE    |     296          464          431          509         |537          410          528          555          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.211      (e)          P=0.027 *    P=0.259     |P=0.179N     P=0.436      P=0.145      P=0.327N     | 
|POLY 3             |     P=1.000N     (e)          P=1.000N     P=1.000N    |P=0.245N     P=0.586N     P=0.580N     P=0.317N     | 
|POLY 1.5           |     P=0.945N     (e)          P=0.967N     P=1.000N    |P=0.272N     P=0.524      P=0.587N     P=0.402N     | 
|POLY 6             |     P=1.000N     (e)          P=1.000N     P=1.000N    |P=0.222N     P=0.438N     P=0.610N     P=0.247N     | 
|LOGISTIC REGRESSION|     P=0.598N     (e)          P=0.328N     (e)         |P=0.237N     P=0.494      P=0.533      P=0.350N     | 
|COCH-ARM / FISHERS |     P=0.419N     (e)          P=0.247N     P=0.500N    |P=0.354N     P=0.194      P=0.500      P=0.602N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  34/50 (68%)  40/50 (80%)  40/50 (80%) |33/50 (66%)  27/50 (54%)  32/50 (64%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     35/47.94     34/48.06     40/46.78     40/47.51    |33/47.86     27/47.68     32/48.46     23/47.78     | 
|POLY-3 PERCENT (g) |     73.0%        70.8%        85.5%        84.2%       |69.0%        56.6%        66.0%        48.1%        | 
|TERMINAL (d)       |     17/27 (63%)  19/29 (66%)  13/16 (81%)  20/22 (91%) |20/33 (61%)  20/34 (59%)  14/28 (50%)  16/36 (44%)  | 
|FIRST INCIDENCE    |     296          464          361          254         |284          642          471          519          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.066      P=0.372N     P=0.010 *    P=0.093     |P=0.045N*    P=0.144N     P=0.405      P=0.034N*    | 
|POLY 3             |     P=0.079      P=0.492N     P=0.096      P=0.128     |P=0.040N*    P=0.147N     P=0.465N     P=0.028N*    | 
|POLY 1.5           |     P=0.100      P=0.495N     P=0.110      P=0.153     |P=0.042N*    P=0.141N     P=0.463N     P=0.029N*    | 
|POLY 6             |     P=0.049 *    P=0.490N     P=0.078      P=0.090     |P=0.038N*    P=0.160N     P=0.472N     P=0.029N*    | 
|LOGISTIC REGRESSION|     P=0.120      P=0.517N     P=0.152      P=0.178     |P=0.050N     P=0.140N     P=0.505N     P=0.038N*    | 
|COCH-ARM / FISHERS |     P=0.122      P=0.500N     P=0.178      P=0.178     |P=0.047N*    P=0.154N     P=0.500N     P=0.035N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/14/01                           EXPERIMENT: 90004 TEST: 07                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -         PROPYLENE GLYCOL MONO-T-BUTYL ETHER
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      75 PPM       300 PPM      1200 PPM    |CONTROL      75 PPM       300 PPM      1200 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 49/50 (98%)  50/50 (100%)|49/50 (98%)  48/50 (96%)  50/50 (100%) 45/50 (90%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     49/49.00     50/50.00    |49/49.01     48/50.00     50/50.00     45/49.06     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |100.0%       96.0%        100.0%       91.7%        | 
|TERMINAL (d)       |     27/27 (100%) 29/29 (100%) 16/16 (100%) 22/22 (100%)|33/33 (100%) 32/34 (94%)  28/28 (100%) 32/36 (89%)  | 
|FIRST INCIDENCE    |     296          464          361          254         |284          410          471          519          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.173      (e)          P=0.021 *    (e)         |P=0.092N     P=0.339N     P=0.163      P=0.120N     | 
|POLY 3             |     P=1.000      (e)          P=1.000N     (e)         |P=0.028N*    P=0.245N     P=1.000      P=0.058N     | 
|POLY 1.5           |     P=1.000      (e)          P=1.000N     (e)         |P=0.023N*    P=0.269N     P=1.000      P=0.055N     | 
|POLY 6             |     P=1.000      (e)          P=1.000N     (e)         |P=0.030N*    P=0.242N     P=1.000      P=0.061N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.016N*    P=0.273N     (e)          P=0.038N*    | 
|COCH-ARM / FISHERS |     P=0.772      (e)          P=0.500N     (e)         |P=0.027N*    P=0.500N     P=0.500      P=0.102N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).