TDMS Study 90004-07 Pathology Tables
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
FINAL#2/RATS
Facility: Battelle Northwest
Chemical CAS #: 57018-52-7
Lock Date: 12/11/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 8| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 0| 7| 2| 1| 1| 1| 1| 0| 1| 1| 2| 2| 8| 2| 5| 1| 2| 1| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | 4 4 4 4 |
Infarct | |
Inflammation, Granulomatous | |
Vacuolization Cytoplasmic | 4 |
Bile Duct, Dilatation | |
Serosa, Hemorrhage | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Necrosis | 3 2 3 1 1 3 2 |
Fat, Hemorrhage | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 8| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 0| 7| 2| 1| 1| 1| 1| 0| 1| 1| 2| 2| 8| 2| 5| 1| 2| 1| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 4 |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + A + + + + + + +|
Degeneration, Cystic | 4 |
Hyperplasia | |
Metaplasia, Osseous | |
Vacuolization Cytoplasmic | 4 3 1 2 3 1 1 2 2 2 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | 4 3 |
Hemorrhage | |
Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
C-Cell, Hyperplasia | 3 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 8| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 0| 7| 2| 1| 1| 1| 1| 0| 1| 1| 2| 2| 8| 2| 5| 1| 2| 1| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | 4 |
Hemorrhage, Chronic | |
Hemorrhage | |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
Deep Cervical, Inflammation, Chronic | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M M M M M + M M M + M M M M M M M|
Angiectasis | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M + M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + M + M|
Angiectasis | |
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 3 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 8| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 0| 7| 2| 1| 1| 1| 1| 0| 1| 1| 2| 2| 8| 2| 5| 1| 2| 1| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Accessory Spleen | X |
Hemorrhage | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + A + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Necrosis | 4 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + A + + + + + + +|
Compression | 4 X 3 3 |
Hemorrhage | 3 3 |
|__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + A + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 2 1 1 |
Thrombosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 8| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 0| 7| 2| 1| 1| 1| 1| 0| 1| 1| 2| 2| 8| 2| 5| 1| 2| 1| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 2 1 2 2 1 |
Alveolus, Proteinosis | 2 1 |
Bronchiole, Hyperplasia | |
Interstitium, Fibrosis | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +|
Foreign Body | 3 3 |
Inflammation, Suppurative | 4 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 2 1 3 4 |
Respiratory Epithelium, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 2 3 1 2 1 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + A + + + + + + +|
Phthisis Bulbi | |
Lens, Cataract | 3 |
Sclera, Inflammation, Suppurative | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + M + + + + M + + + + + M + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Nephropathy, Chronic | 2 1 1 1 1 1 1 2 1 1 2 3 2 1 1 1 1 1 1 3 3 2 1|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 8| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 0| 7| 2| 1| 1| 1| 1| 0| 1| 1| 2| 2| 8| 2| 5| 1| 2| 1| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 4 |
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hemorrhage | 3 |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 5| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 1| 3| 3| 1| 3| 3| 3| 8| 8| 2| 9| 3| 3| 7| 0| 3| 3| 3| 3| |
| 2| 1| 2| 0| 0| 7| 8| 1| 2| 5| 1| 2| 0| 4| 4| 5| 3| 0| 1| 1| 8| 1| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + A + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + A + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + A + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 39 |
Clear Cell Focus | X X X X X | 12 |
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | 4 4 4 4| 8 4.0|
Infarct | 4 | 1 4.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 1 | 3 2.7|
Bile Duct, Dilatation | 4 | 1 4.0|
Serosa, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + | 17 |
Necrosis | 2 2 3 3 3 3 3 3 3 3 | 17 2.5|
Fat, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 5| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 1| 3| 3| 1| 3| 3| 3| 8| 8| 2| 9| 3| 3| 7| 0| 3| 3| 3| 3| |
| 2| 1| 2| 0| 0| 7| 8| 1| 2| 5| 1| 2| 0| 4| 4| 5| 3| 0| 1| 1| 8| 1| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Tongue | + | 2 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | | 1 4.0|
Hyperplasia | 2 2 | 2 2.0|
Metaplasia, Osseous | 3 | 1 3.0|
Vacuolization Cytoplasmic | 3 1 4 3| 15 2.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 5| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 1| 3| 3| 1| 3| 3| 3| 8| 8| 2| 9| 3| 3| 7| 0| 3| 3| 3| 3| |
| 2| 1| 2| 0| 0| 7| 8| 1| 2| 5| 1| 2| 0| 4| 4| 5| 3| 0| 1| 1| 8| 1| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Angiectasis | 3 3 | 4 3.3|
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 3 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 1 1 | 9 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 | 2 3.0|
Hyperplasia | 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 2 1 2 | 6 2.8|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Decidual Reaction | | 1 4.0|
Hemorrhage, Chronic | 4 | 1 4.0|
Hemorrhage | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Deep Cervical, Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 5| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 1| 3| 3| 1| 3| 3| 3| 8| 8| 2| 9| 3| 3| 7| 0| 3| 3| 3| 3| |
| 2| 1| 2| 0| 0| 7| 8| 1| 2| 5| 1| 2| 0| 4| 4| 5| 3| 0| 1| 1| 8| 1| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Bronchial | + M M + M + + M M M M + M M M M + M M M + M M M M| 9 |
Angiectasis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + M + + + + M + + + + + + + + + M + + + M| 43 |
Angiectasis | 4 1 4 | 3 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Pigmentation | 2 | 3 2.7|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | | 1 |
Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + + M + + + M| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Maxilla, Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 5| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 1| 3| 3| 1| 3| 3| 3| 8| 8| 2| 9| 3| 3| 7| 0| 3| 3| 3| 3| |
| 2| 1| 2| 0| 0| 7| 8| 1| 2| 5| 1| 2| 0| 4| 4| 5| 3| 0| 1| 1| 8| 1| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | X | 5 3.3|
Hemorrhage | 2 4 | 4 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 4 | 1 4.0|
Inflammation, Suppurative | 3 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic | 1 2 1 1 2 | 9 1.3|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 4 4 3 | 6 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 1 2 1 1 | 15 1.4|
Alveolus, Proteinosis | 2 1 | 4 1.5|
Bronchiole, Hyperplasia | 2| 1 2.0|
Interstitium, Fibrosis | 1 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 2 3.0|
Inflammation, Suppurative | | 4 2.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 3 2 1| 10 1.9|
Respiratory Epithelium, Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 1 1 1| 15 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 5| 7| 7| 1| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 1| 3| 3| 1| 3| 3| 3| 8| 8| 2| 9| 3| 3| 7| 0| 3| 3| 3| 3| |
| 2| 1| 2| 0| 0| 7| 8| 1| 2| 5| 1| 2| 0| 4| 4| 5| 3| 0| 1| 1| 8| 1| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Phthisis Bulbi | X | 1 |
Lens, Cataract | | 1 3.0|
Sclera, Inflammation, Suppurative | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Zymbal's Gland | M + + + + + M + + + + + + + + + + + M + + + + M +| 42 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 1 1 1 3 1 1 1 1 2 1 1 2 1 2 2 3 1 1 1 2 2 2| 45 1.5|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | | 1 4.0|
Pelvis, Mineralization | 1 1 1 1 2 | 13 1.1|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 0| 3| 7| 2| 3| 3| 8| 3| 3| 3| 8| 3| 3|
| 0| 2| 2| 1| 1| 4| 1| 0| 2| 0| 6| 1| 8| 1| 6| 6| 2| 2| 3| 1| 2| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + A + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Fatty Change | |
Hepatodiaphragmatic Nodule | 4 4 4 4 4 4 4 |
Necrosis | 4 |
Vacuolization Cytoplasmic | 4 2 4 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + |
Necrosis | 3 3 3 3 2 2 4 1 2 3 3 3 4 |
Fat, Hemorrhage | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 0| 3| 7| 2| 3| 3| 8| 3| 3| 3| 8| 3| 3|
| 0| 2| 2| 1| 1| 4| 1| 0| 2| 0| 6| 1| 8| 1| 6| 6| 2| 2| 3| 1| 2| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 |
Atrium, Thrombosis | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Vacuolization Cytoplasmic | 1 1 4 4 2 2 4|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Hyperplasia | 1 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Hyperplasia | 4 4 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 0| 3| 7| 2| 3| 3| 8| 3| 3| 3| 8| 3| 3|
| 0| 2| 2| 1| 1| 4| 1| 0| 2| 0| 6| 1| 8| 1| 6| 6| 2| 2| 3| 1| 2| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Cyst | 4 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M M M M M M M M M + M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M + M|
Ectasia | 4 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + + M + + + + + + M + + + + +|
Angiectasis | 4 |
Fibrosis | 3 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 2 |
Pigmentation | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Degeneration | 1 |
Necrosis | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 4 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 0| 3| 7| 2| 3| 3| 8| 3| 3| 3| 8| 3| 3|
| 0| 2| 2| 1| 1| 4| 1| 0| 2| 0| 6| 1| 8| 1| 6| 6| 2| 2| 3| 1| 2| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Tibia, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 X 3 |
Hemorrhage | 1 4 |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 1 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 1 |
Alveolar Epithelium, Hyperplasia | 1 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Bronchiole, Hyperplasia | |
Interstitium, Fibrosis | 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +|
Foreign Body | 3 |
Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Degeneration, | |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 0| 3| 7| 2| 3| 3| 8| 3| 3| 3| 8| 3| 3|
| 0| 2| 2| 1| 1| 4| 1| 0| 2| 0| 6| 1| 8| 1| 6| 6| 2| 2| 3| 1| 2| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hyaline | 2 2 1 1 1 1 1 3 2 3 |
Respiratory Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 2 4 3 |
Lens, Mineralization | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + + + + + M + M + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 4 |
Nephropathy, Chronic | 2 1 1 1 2 2 2 1 1 2 2 3 1 1 1 1 2 2 1 2 1 3|
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 4 3 |
Pelvis, Mineralization | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 18
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 4| 2| 3| 3| 3| 2| 3| 4| 2| |
| 1| 2| 2| 2| 0| 1| 1| 0| 0| 1| 2| 0| 2| 2| 6| 2| 2| 6| 2| 1| 2| 1| 0| 2| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 45 |
Clear Cell Focus | X X X X X X | 13 |
Fatty Change | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 4 4 4 | 10 4.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 3 | 4 3.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + | 23 |
Necrosis | 3 3 2 3 2 3 2 2 | 21 2.7|
Fat, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 4| 2| 3| 3| 3| 2| 3| 4| 2| |
| 1| 2| 2| 2| 0| 1| 1| 0| 0| 1| 2| 0| 2| 2| 6| 2| 2| 6| 2| 1| 2| 1| 0| 2| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 | 3 2.7|
Atrium, Thrombosis | | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Vacuolization Cytoplasmic | 1 4 2| 10 2.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 4 2.3|
Hyperplasia | 4 3 4 3 | 6 2.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 1 1 2 3 | 8 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 4| 2| 3| 3| 3| 2| 3| 4| 2| |
| 1| 2| 2| 2| 0| 1| 1| 0| 0| 1| 2| 0| 2| 2| 6| 2| 2| 6| 2| 1| 2| 1| 0| 2| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 3 4.0|
Hyperplasia | 4 | 3 4.0|
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 4 | 5 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M M M M M M M M + M M + + M M M M M M M M| 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M + M M M M M M M M| 2 |
Ectasia | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3| 1 3.0|
Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Angiectasis | | 1 4.0|
Fibrosis | | 1 3.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | 4 | 2 3.0|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 4| 2| 3| 3| 3| 2| 3| 4| 2| |
| 1| 2| 2| 2| 0| 1| 1| 0| 0| 1| 2| 0| 2| 2| 6| 2| 2| 6| 2| 1| 2| 1| 0| 2| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Accessory Spleen | 3 | 2 3.0|
Degeneration | | 1 1.0|
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 4 4 4 | 7 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 | 1 4.0|
Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
Tibia, Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 X 3 X 3 3| 9 3.0|
Hemorrhage | 2 | 3 2.3|
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 2 1.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 4| 2| 3| 3| 3| 2| 3| 4| 2| |
| 1| 2| 2| 2| 0| 1| 1| 0| 0| 1| 2| 0| 2| 2| 6| 2| 2| 6| 2| 1| 2| 1| 0| 2| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
Inflammation, Chronic | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 | 9 1.0|
Bronchiole, Hyperplasia | 1 | 1 1.0|
Interstitium, Fibrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 3 | 2 3.0|
Inflammation, Suppurative | 2 | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 3 2 3 3 3 3 2 1 2 1| 22 2.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 2 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | 4 | 4 3.3|
Lens, Mineralization | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + M + + + + + + + + + + + + + M + + + M| 44 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 4| 2| 3| 3| 3| 2| 3| 4| 2| |
| 1| 2| 2| 2| 0| 1| 1| 0| 0| 1| 2| 0| 2| 2| 6| 2| 2| 6| 2| 1| 2| 1| 0| 2| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 4.0|
Nephropathy, Chronic | 1 2 2 4 1 1 1 3 1 1 2 1 1 2 1 3 1 1 2 2 1 2 2| 45 1.6|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | | 2 3.5|
Pelvis, Mineralization | 1 1 1 1 1 | 5 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 5| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 7| 3| 3| 3| 9| 1| 4| 1| 3| 3| 5| 0| 2| 3| 9| 3| 3| 3| 3| 8|
| 2| 2| 2| 2| 7| 0| 2| 1| 0| 8| 7| 6| 2| 1| 4| 9| 9| 3| 1| 8| 1| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Hepatodiaphragmatic Nodule | 1 4 4 4 |
Inflammation, Granulomatous | |
Necrosis | |
Vacuolization Cytoplasmic | 4 |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Necrosis | 1 3 3 3 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Ulcer | 4 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 5| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 7| 3| 3| 3| 9| 1| 4| 1| 3| 3| 5| 0| 2| 3| 9| 3| 3| 3| 3| 8|
| 2| 2| 2| 2| 7| 0| 2| 1| 0| 8| 7| 6| 2| 1| 4| 9| 9| 3| 1| 8| 1| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Epicardium, Inflammation, Chronic | 4 |
Myocardium, Degeneration | |
Myocardium, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | |
Vacuolization Cytoplasmic | 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | |
Hyperplasia | 3|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 5| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 7| 3| 3| 3| 9| 1| 4| 1| 3| 3| 5| 0| 2| 3| 9| 3| 3| 3| 3| 8|
| 2| 2| 2| 2| 7| 0| 2| 1| 0| 8| 7| 6| 2| 1| 4| 9| 9| 3| 1| 8| 1| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Hyperplasia | 4 |
Inflammation, Chronic | 4 4 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hemorrhage | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Deep Cervical, Infiltration Cellular,| |
Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M + + M M + + M + M M M M M M + M M M M M|
Infiltration Cellular, Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M M M M M M M M M M M M M M M M M M|
Ectasia | 4 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | |
Fibrosis | |
Infiltration Cellular, Histiocyte | |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 5| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 7| 3| 3| 3| 9| 1| 4| 1| 3| 3| 5| 0| 2| 3| 9| 3| 3| 3| 3| 8|
| 2| 2| 2| 2| 7| 0| 2| 1| 0| 8| 7| 6| 2| 1| 4| 9| 9| 3| 1| 8| 1| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 X 2 |
Hemorrhage | 4 4 |
Medulla, Gliosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Epiglottis, Metaplasia, Squamous | 2 |
Respiratory Epithelium, Epiglottis, | |
Degeneration | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 |
Alveolus, Proteinosis | 1 1 |
Interstitium, Fibrosis | 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 5| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 7| 3| 3| 3| 9| 1| 4| 1| 3| 3| 5| 0| 2| 3| 9| 3| 3| 3| 3| 8|
| 2| 2| 2| 2| 7| 0| 2| 1| 0| 8| 7| 6| 2| 1| 4| 9| 9| 3| 1| 8| 1| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Mediastinum, Inflammation, | |
Granulomatous | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 1 3 2 1 1 1 3 4 1 4 4 2 1 2 1 1 1 1 3 1 3 1|
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Phthisis Bulbi | |
Anterior Chamber, Sclera, | |
Inflammation, Suppurative | |
Cornea, Inflammation, Chronic | |
Lens, Cataract | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + M + + + M + + M + + + + + + + + + M + + + + + +|
Cyst | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 2 1 2 2 3 4 1 1 2 1 2 1 1 1 1 3 1 2 1 3 3 1|
Cortex, Renal Tubule, Hyperplasia | |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 5| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 7| 3| 3| 3| 9| 1| 4| 1| 3| 3| 5| 0| 2| 3| 9| 3| 3| 3| 3| 8|
| 2| 2| 2| 2| 7| 0| 2| 1| 0| 8| 7| 6| 2| 1| 4| 9| 9| 3| 1| 8| 1| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Pelvis, Mineralization | 1 1 1 1 |
Renal Tubule, Mineralization | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Ulcer | 3 |
Transitional Epithelium, | |
Mineralization | 3 |
__________________________________________|__________________________________________________________________________
Page 30
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 0| 1| 2| 3| 3| 3| 0| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 7| |
| 7| 2| 8| 0| 1| 2| 9| 2| 0| 2| 3| 1| 0| 1| 1| 1| 1| 6| 1| 6| 1| 1| 2| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 2 | 3 2.3|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X| 43 |
Clear Cell Focus | X X X X X X X | 11 |
Hepatodiaphragmatic Nodule | 4 4 4 4 4 | 9 3.7|
Inflammation, Granulomatous | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 4 4 | 3 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Necrosis | 1 3 2 | 9 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 0| 1| 2| 3| 3| 3| 0| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 7| |
| 7| 2| 8| 0| 1| 2| 9| 2| 0| 2| 3| 1| 0| 1| 1| 1| 1| 6| 1| 6| 1| 1| 2| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Ulcer | 4 4 | 4 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Epicardium, Inflammation, Chronic | | 1 4.0|
Myocardium, Degeneration | 3 | 1 3.0|
Myocardium, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia | 2 2 | 2 2.0|
Vacuolization Cytoplasmic | 2 3 4 1 | 6 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 3.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 2 3 | 3 2.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 0| 1| 2| 3| 3| 3| 0| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 7| |
| 7| 2| 8| 0| 1| 2| 9| 2| 0| 2| 3| 1| 0| 1| 1| 1| 1| 6| 1| 6| 1| 1| 2| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
C-Cell, Hyperplasia | 4 1 2 4 | 7 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 1 1.0|
Hyperplasia | 3 | 2 3.5|
Inflammation, Chronic | | 2 4.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 | 3 3.7|
Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 4.0|
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Deep Cervical, Infiltration Cellular,| | |
Histiocyte | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M M M M M M M + M M M M + M M M M M M M M +| 10 |
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M + M M M M M M M M M M M M M M M M M| 2 |
Ectasia | | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 0| 1| 2| 3| 3| 3| 0| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 7| |
| 7| 2| 8| 0| 1| 2| 9| 2| 0| 2| 3| 1| 0| 1| 1| 1| 1| 6| 1| 6| 1| 1| 2| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + M + + + M + + + + + + + + + + + + + +| 45 |
Angiectasis | 4 | 1 4.0|
Fibrosis | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 4 4 4 2 | 4 3.5|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 4.0|
Hyperkeratosis | | 1 1.0|
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + +| 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 X X X | 8 3.0|
Hemorrhage | 4 4 4 3 | 6 3.8|
Medulla, Gliosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 0| 1| 2| 3| 3| 3| 0| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 7| |
| 7| 2| 8| 0| 1| 2| 9| 2| 0| 2| 3| 1| 0| 1| 1| 1| 1| 6| 1| 6| 1| 1| 2| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
Epiglottis, Metaplasia, Squamous | | 1 2.0|
Respiratory Epithelium, Epiglottis, | | |
Degeneration | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 3 1 | 7 1.4|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 2 2 | 5 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 2 1 3 1 1 1 1 2 | 13 1.5|
Alveolus, Proteinosis | 1 | 3 1.0|
Interstitium, Fibrosis | 3 | 4 2.3|
Mediastinum, Inflammation, | | |
Granulomatous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 | 2 3.0|
Inflammation, Suppurative | 3 3 2 3 | 5 2.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 | 4 2.8|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 3 4 1 3 4 3 1 4 1 3 1 1 3 4 4 1 3 2 1 4 4 2| 48 2.3|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 2 2 1 3 1 1 2 | 11 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 0| 1| 2| 3| 3| 3| 0| 3| 1| 3| 9| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 7| |
| 7| 2| 8| 0| 1| 2| 9| 2| 0| 2| 3| 1| 0| 1| 1| 1| 1| 6| 1| 6| 1| 1| 2| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 | 2 4.0|
Phthisis Bulbi | X | 1 |
Anterior Chamber, Sclera, | | |
Inflammation, Suppurative | 4 | 1 4.0|
Cornea, Inflammation, Chronic | 1 | 1 1.0|
Lens, Cataract | 3 4 3 | 3 3.3|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + M + + + + + + + + + + + + M + M + + + + + + + +| 43 |
Cyst | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 1 1 4 2 1 1 2 1 1 2 1 1 1 3 2 2 3 1 2 3 | 45 1.7|
Cortex, Renal Tubule, Hyperplasia | 4 | 1 4.0|
Pelvis, Mineralization | 1 1 1 | 7 1.0|
Renal Tubule, Mineralization | 2| 2 2.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2| 1 2.0|
Ulcer | | 1 3.0|
Transitional Epithelium, | | |
Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 8| 3|
| 2| 1| 1| 9| 1| 2| 1| 2| 6| 1| 2| 2| 1| 1| 0| 2| 2| 2| 2| 0| 7| 5| 0| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + A +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + A +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | 2 X X X X X X X X X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | 4 4 4 |
Inflammation, Granulomatous | 1 |
Necrosis | 4 |
Thrombosis | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + +|
Necrosis | 2 3 3 2 3 2 3 3 3 2 2 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Erosion | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 8| 3|
| 2| 1| 1| 9| 1| 2| 1| 2| 6| 1| 2| 2| 1| 1| 0| 2| 2| 2| 2| 0| 7| 5| 0| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Tongue | + |
Epithelium, Hyperkeratosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 |
Hyperplasia | |
Vacuolization Cytoplasmic | 1 1 4 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | 4 |
Cyst | |
Hyperplasia | 3 3 4 |
Pars Intermedia, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 8| 3|
| 2| 1| 1| 9| 1| 2| 1| 2| 6| 1| 2| 2| 1| 1| 0| 2| 2| 2| 2| 0| 7| 5| 0| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Cyst | 4 4 4 4|
Hyperplasia | |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 4 1 1|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Endometrium, Hyperplasia | 3 3 |
Endometrium, Ulcer | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M M M M M + M M M M + M M M M M M|
Angiectasis | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + M + + M + + M +|
Angiectasis | 4 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 4 |
Hematopoietic Cell Proliferation | 4 |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 8| 3|
| 2| 1| 1| 9| 1| 2| 1| 2| 6| 1| 2| 2| 1| 1| 0| 2| 2| 2| 2| 0| 7| 5| 0| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Galactocele | 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | |
Subcutaneous Tissue, Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metatarsal, Fracture | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Epiglottis, Metaplasia, Squamous | 1 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Hemorrhage | |
Inflammation, Chronic | 1 2 2|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 1 1 2 2 1 2 3|
Alveolus, Proteinosis | 1 1 |
Interstitium, Fibrosis | 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 1 2 1 2 |
Goblet Cell, Hyperplasia | 1 2 |
Nasolacrimal Duct, Inflammation, | |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 8| 3|
| 2| 1| 1| 9| 1| 2| 1| 2| 6| 1| 2| 2| 1| 1| 0| 2| 2| 2| 2| 0| 7| 5| 0| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Suppurative | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 4 4 4 4 3 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 2 4 3 3|
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1 1 2 1 1 2 1 1 3|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Edema | |
Cornea, Inflammation, Chronic | |
Cornea, Mineralization | 1 1 1 2 2 |
Cornea, Necrosis | |
Lens, Cataract | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + + |
|__________________________________________________________________________|
Zymbal's Gland | + + M + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 1 1 1 3 2 3 2 1 1 2 3 3 1 1 1 3 3 2 1 4 3 4 3|
Cortex, Infarct | |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 4 |
Cortex, Renal Tubule, Hyperplasia | 1 |
Pelvis, Mineralization | 1 1 1 |
|__________________________________________________________________________|
Urethra | + |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 8| 3|
| 2| 1| 1| 9| 1| 2| 1| 2| 6| 1| 2| 2| 1| 1| 0| 2| 2| 2| 2| 0| 7| 5| 0| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Transitional Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 42
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 4| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| |
| 1| 1| 2| 6| 2| 0| 4| 2| 0| 5| 2| 2| 1| 2| 4| 0| 2| 1| 2| 2| 2| 9| 0| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 40 |
Clear Cell Focus | X X X X X X X X X X X X X| 27 2.0|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | 4 4 4 4 | 7 4.0|
Inflammation, Granulomatous | 2 | 2 1.5|
Necrosis | 2 | 2 3.0|
Thrombosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 17 |
Necrosis | 1 3 3 2 2 | 17 2.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 4| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| |
| 1| 1| 2| 6| 2| 0| 4| 2| 0| 5| 2| 2| 1| 2| 4| 0| 2| 1| 2| 2| 2| 9| 0| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperkeratosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 5 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 3 4 | 4 3.3|
Cyst | 4 | 1 4.0|
Hyperplasia | | 3 3.3|
Pars Intermedia, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 4| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| |
| 1| 1| 2| 6| 2| 0| 4| 2| 0| 5| 2| 2| 1| 2| 4| 0| 2| 1| 2| 2| 2| 9| 0| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
C-Cell, Hyperplasia | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 4 4.0|
Hyperplasia | 3 4 | 2 3.5|
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 4 | 8 3.3|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Endometrium, Hyperplasia | | 2 3.0|
Endometrium, Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M + M M M M M + M M M M M M M M M M M M + M| 5 |
Angiectasis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + M + + + + M + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 4| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| |
| 1| 1| 2| 6| 2| 0| 4| 2| 0| 5| 2| 2| 1| 2| 4| 0| 2| 1| 2| 2| 2| 9| 0| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Angiectasis | 3 | 2 3.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 2 3.5|
Hematopoietic Cell Proliferation | | 1 4.0|
Necrosis | 4 4 3 | 3 3.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Ulcer | 4 | 1 4.0|
Subcutaneous Tissue, Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metatarsal, Fracture | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 | 4 2.8|
Hemorrhage | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 4| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| |
| 1| 1| 2| 6| 2| 0| 4| 2| 0| 5| 2| 2| 1| 2| 4| 0| 2| 1| 2| 2| 2| 9| 0| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Epiglottis, Metaplasia, Squamous | | 2 1.5|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 3.0|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 2 2 1 | 6 1.7|
Alveolar Epithelium, Hyperplasia | 1 4 2 | 4 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 1 1 1 2 2 2 2 2 1| 20 1.6|
Alveolus, Proteinosis | | 2 1.0|
Interstitium, Fibrosis | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Dilatation | | 4 1.5|
Goblet Cell, Hyperplasia | 2 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 3 3 3 3 4 2 3 4 4 2 3 4 2 4 3 3 4 4 3 4 4 4 4 4 4| 50 3.6|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 1 2 1 | 17 1.4|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cornea, Edema | 3 | 1 3.0|
Cornea, Inflammation, Chronic | 2 | 1 2.0|
Cornea, Mineralization | 2 1 2 1 2 | 10 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 4| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| |
| 1| 1| 2| 6| 2| 0| 4| 2| 0| 5| 2| 2| 1| 2| 4| 0| 2| 1| 2| 2| 2| 9| 0| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Cornea, Necrosis | 2 | 1 2.0|
Lens, Cataract | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 2 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + M + + + + + + + + + + + + + + + + + + + + M + +| 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 4 1 1 3 3 1 3 3 1 X 1 1 3 3 3 2 1 1 2 3 1 2 2 4| 49 2.1|
Cortex, Infarct | 4 | 1 4.0|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | | 1 4.0|
Cortex, Renal Tubule, Hyperplasia | | 1 1.0|
Pelvis, Mineralization | | 3 1.0|
|__________________________________________________________________________|____________|
Urethra | | 1 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 6| 7| 7| 4| 2| 7| 6| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 2| 2| 0| 1| 2| 2| 5| 0| 4| 4| 2| 2| 5| 9| 3| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 0| 9| 9| 9| 8| 9| 9| 5| 4| 2| 6| 9| 9| 8| 6| 0| 4| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X |
Degeneration, Cystic | |
Fatty Change | 2 2 |
Hepatodiaphragmatic Nodule | |
Thrombosis | |
Vacuolization Cytoplasmic | |
Bile Duct, Cyst | |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Necrosis | 2 2 2 2 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation, Suppurative | |
Ulcer | 4 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 6| 7| 7| 4| 2| 7| 6| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 2| 2| 0| 1| 2| 2| 5| 0| 4| 4| 2| 2| 5| 9| 3| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 0| 9| 9| 9| 8| 9| 9| 5| 4| 2| 6| 9| 9| 8| 6| 0| 4| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
|__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 2 3 2 |
Atrium, Thrombosis | |
Myocardium, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Vacuolization Cytoplasmic | 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Hyperplasia | 2 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 6| 7| 7| 4| 2| 7| 6| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 2| 2| 0| 1| 2| 2| 5| 0| 4| 4| 2| 2| 5| 9| 3| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 0| 9| 9| 9| 8| 9| 9| 5| 4| 2| 6| 9| 9| 8| 6| 0| 4| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
C-Cell, Hyperplasia | 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 1 1 3 2 2 2 2 1 1 1 2 1 2 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 3 2 3 1 4 3 3 3 3|
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Deep Cervical, Hyperplasia, Lymphoid | 3 |
Pancreatic, Ectasia | 4 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + M + M M + + M + + M M M M M M M M M M|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 6| 7| 7| 4| 2| 7| 6| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 2| 2| 0| 1| 2| 2| 5| 0| 4| 4| 2| 2| 5| 9| 3| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 0| 9| 9| 9| 8| 9| 9| 5| 4| 2| 6| 9| 9| 8| 6| 0| 4| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M M M M + M M M + + + + + M M + + + + + +|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 2 3 |
Hemorrhage | 4 |
Necrosis | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + M M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | 3 |
Ulcer | |
Sebaceous Gland, Hyperplasia, | |
Squamous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3|
Hemorrhage | 4 |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 6| 7| 7| 4| 2| 7| 6| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 2| 2| 0| 1| 2| 2| 5| 0| 4| 4| 2| 2| 5| 9| 3| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 0| 9| 9| 9| 8| 9| 9| 5| 4| 2| 6| 9| 9| 8| 6| 0| 4| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 2 1 1 1|
Necrosis, Focal | |
Alveolar Epithelium, Hyperplasia | 1 1|
Alveolar Epithelium, Metaplasia, | |
Squamous | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1 1 1 2|
Interstitium, Fibrosis | 1 2 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 3|
Inflammation, Suppurative | 2 1 2|
Glands, Dilatation | |
Goblet Cell, Hyperplasia | 1|
Respiratory Epithelium, Hyperplasia | 2 2|
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + + |
|__________________________________________________________________________|
Zymbal's Gland | + + M + M M + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 6| 7| 7| 4| 2| 7| 6| 7| 6| 6|
DAY ON TEST | 3| 2| 2| 2| 2| 3| 2| 2| 0| 1| 2| 2| 5| 0| 4| 4| 2| 2| 5| 9| 3| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 0| 9| 9| 9| 8| 9| 9| 5| 4| 2| 6| 9| 9| 8| 6| 0| 4| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 3 1 1 2 2 2 1 2 2 2 2 1 1 2 1 2 1 3 1 2|
Cortex, Infarct | 3 3 |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | |
Pelvis, Dilatation | 4 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Mineralization | 3 |
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Urethra | + |
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Necrosis | |
Ulcer | |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 54
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 3| 8| 2| 1| 2| 3| 2| 2| 2| 6| 6| 2| 5| 2| 1| 3| 5| 4| 2| 2| 3| |
| 5| 9| 0| 0| 0| 1| 9| 2| 9| 0| 9| 9| 9| 5| 8| 9| 6| 3| 2| 0| 5| 2| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X | 6 |
Clear Cell Focus | X X X | 8 |
Degeneration, Cystic | 3 | 1 3.0|
Fatty Change | 2 | 3 2.0|
Hepatodiaphragmatic Nodule | 4 | 1 4.0|
Thrombosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 3 3 3 | 3 3.0|
Bile Duct, Cyst | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 13 |
Necrosis | 4 2 3 3 2 3 2 | 13 2.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 3| 8| 2| 1| 2| 3| 2| 2| 2| 6| 6| 2| 5| 2| 1| 3| 5| 4| 2| 2| 3| |
| 5| 9| 0| 0| 0| 1| 9| 2| 9| 0| 9| 9| 9| 5| 8| 9| 6| 3| 2| 0| 5| 2| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hyperplasia, Squamous | 3 | 2 2.5|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 4 | 3 3.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Tongue | + + | 2 |
Epithelium, Hyperplasia | 3 4 | 2 3.5|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 | 7 2.1|
Atrium, Thrombosis | 4 | 1 4.0|
Myocardium, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 2 2 3 | 6 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 6 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 3| 8| 2| 1| 2| 3| 2| 2| 2| 6| 6| 2| 5| 2| 1| 3| 5| 4| 2| 2| 3| |
| 5| 9| 0| 0| 0| 1| 9| 2| 9| 0| 9| 9| 9| 5| 8| 9| 6| 3| 2| 0| 5| 2| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hemorrhage | 4| 1 4.0|
Hyperplasia | 4 3 | 5 2.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 3 1 | 8 1.4|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + | 3 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 2 3.5|
Inflammation, Suppurative | 2 4 4 | 4 3.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 1 1 2 2 2 2 2 1 1 2 2 2 3 1 1 2 3| 31 1.7|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 1 2 1 3 2 2 2 1 3 4 3 | 20 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 3| 8| 2| 1| 2| 3| 2| 2| 2| 6| 6| 2| 5| 2| 1| 3| 5| 4| 2| 2| 3| |
| 5| 9| 0| 0| 0| 1| 9| 2| 9| 0| 9| 9| 9| 5| 8| 9| 6| 3| 2| 0| 5| 2| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Interstitial Cell, Hyperplasia | 3 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + | 12 |
Deep Cervical, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Ectasia | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + M + + + M M + M M + + + M + + M + M M| 24 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M + M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + + M + + + + + + + + + + + + +| 38 |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X X | 2 |
Fibrosis | 1 3 3 | 5 2.4|
Hemorrhage | | 1 4.0|
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 4 | 3 3.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 3| 8| 2| 1| 2| 3| 2| 2| 2| 6| 6| 2| 5| 2| 1| 3| 5| 4| 2| 2| 3| |
| 5| 9| 0| 0| 0| 1| 9| 2| 9| 0| 9| 9| 9| 5| 8| 9| 6| 3| 2| 0| 5| 2| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperkeratosis | 4 3 | 3 3.3|
Ulcer | 2 | 1 2.0|
Sebaceous Gland, Hyperplasia, | | |
Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 4 3 X | 7 3.0|
Hemorrhage | 2 4 4| 4 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 1 | 5 1.2|
Necrosis, Focal | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 1 3 1 1 | 6 1.3|
Alveolar Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 2 2 2 | 11 1.8|
Interstitium, Fibrosis | 2 | 5 1.6|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 3| 8| 2| 1| 2| 3| 2| 2| 2| 6| 6| 2| 5| 2| 1| 3| 5| 4| 2| 2| 3| |
| 5| 9| 0| 0| 0| 1| 9| 2| 9| 0| 9| 9| 9| 5| 8| 9| 6| 3| 2| 0| 5| 2| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Foreign Body | 3 3 3| 6 3.0|
Inflammation, Suppurative | 1 2 2| 6 1.7|
Glands, Dilatation | 2 | 1 2.0|
Goblet Cell, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 2 | 6 1.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 2 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + M + + + + + + M + + + M + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 4 1 1 2 2 2 2 2 3 3 2 3 2 4 1 2 1 2 4 1 2 3 1| 46 1.9|
Cortex, Infarct | 4 3 | 4 3.3|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 3 | 1 3.0|
Pelvis, Dilatation | | 1 4.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 1 | 2 1.0|
Renal Tubule, Mineralization | | 1 3.0|
Renal Tubule, Pigmentation | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 2| 2| 3| 3| 3| 8| 2| 1| 2| 3| 2| 2| 2| 6| 6| 2| 5| 2| 1| 3| 5| 4| 2| 2| 3| |
| 5| 9| 0| 0| 0| 1| 9| 2| 9| 0| 9| 9| 9| 5| 8| 9| 6| 3| 2| 0| 5| 2| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Urethra | | 1 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 2 2 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 3| 2| 2| 6| 3| 3| 1| 3| 2| 3| 3| 0| 1| 2| 9| 4| 2| 2| 0| 0| 2|
| 0| 6| 7| 9| 0| 9| 9| 4| 0| 0| 3| 0| 9| 0| 0| 9| 3| 9| 1| 2| 9| 9| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A A +|
Necrosis | 4 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X X X X X X X|
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | 4 4 |
Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Mesentery | + + + + + |
Necrosis | 4 2 2 2 3 |
Fat, Hemorrhage | |
|__________________________________________________________________________|
Oral Mucosa | |
Ulcer | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 3| 2| 2| 6| 3| 3| 1| 3| 2| 3| 3| 0| 1| 2| 9| 4| 2| 2| 0| 0| 2|
| 0| 6| 7| 9| 0| 9| 9| 4| 0| 0| 3| 0| 9| 0| 0| 9| 3| 9| 1| 2| 9| 9| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + |
Malformation | |
Peridontal Tissue, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 |
Myocardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | 3 4 2 1 2 2 2 1 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3|
Cyst | 4 |
Hemorrhage | |
Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 3| 2| 2| 6| 3| 3| 1| 3| 2| 3| 3| 0| 1| 2| 9| 4| 2| 2| 0| 0| 2|
| 0| 6| 7| 9| 0| 9| 9| 4| 0| 0| 3| 0| 9| 0| 0| 9| 3| 9| 1| 2| 9| 9| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
|__________________________________________________________________________|
Peritoneum | +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 1 1 2 2 1 2 1 2 2 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 1 1 4 2 2 3 4 1 1 1 4 2 2|
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Deep Cervical, Ectasia | 3 |
Deep Cervical, Inflammation | |
Pancreatic, Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M + M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 3| 2| 2| 6| 3| 3| 1| 3| 2| 3| 3| 0| 1| 2| 9| 4| 2| 2| 0| 0| 2|
| 0| 6| 7| 9| 0| 9| 9| 4| 0| 0| 3| 0| 9| 0| 0| 9| 3| 9| 1| 2| 9| 9| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + M + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X |
Fibrosis | |
Necrosis | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
Metaplasia, Squamous | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 3 1 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 4 |
Epiglottis, Hyperplasia | |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 3| 2| 2| 6| 3| 3| 1| 3| 2| 3| 3| 0| 1| 2| 9| 4| 2| 2| 0| 0| 2|
| 0| 6| 7| 9| 0| 9| 9| 4| 0| 0| 3| 0| 9| 0| 0| 9| 3| 9| 1| 2| 9| 9| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 2 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 |
Alveolus, Proteinosis | 2 |
Interstitium, Fibrosis | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 |
Inflammation, Suppurative | 1 3 2 |
Glands, Dilatation | |
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 1 2 1 3 2 1 2 2 2 |
Respiratory Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
Cyst | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + M + + + M + + + + + + + + + + + + + M M|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 3| 2| 2| 6| 3| 3| 1| 3| 2| 3| 3| 0| 1| 2| 9| 4| 2| 2| 0| 0| 2|
| 0| 6| 7| 9| 0| 9| 9| 4| 0| 0| 3| 0| 9| 0| 0| 9| 3| 9| 1| 2| 9| 9| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Nephropathy, Chronic | 3 4 1 2 2 3 2 1 3 2 1 3 2 3 2 3 3 1 3 2 2 2 2 4 3|
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 2 |
Cortex, Renal Tubule, Hyperplasia | |
Papilla, Mineralization | 1 1 1 1 1 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 67
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 1| 3| 7| 6| 2| 2| 2| 2| 5| 2| 2| 3| 4| 8| 4| 2| 2| 4| 0| 3| 2| 2| 2| |
| 6| 9| 9| 0| 5| 9| 9| 9| 9| 9| 6| 9| 9| 0| 2| 9| 8| 9| 1| 2| 9| 0| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X| 18 |
Clear Cell Focus | X X X X | 11 |
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | 4 4 4 4 | 6 4.0|
Vacuolization Cytoplasmic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Necrosis | 3 2 2 2 | 9 2.4|
Fat, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 1| 3| 7| 6| 2| 2| 2| 2| 5| 2| 2| 3| 4| 8| 4| 2| 2| 4| 0| 3| 2| 2| 2| |
| 6| 9| 9| 0| 5| 9| 9| 9| 9| 9| 6| 9| 9| 0| 2| 9| 8| 9| 1| 2| 9| 0| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Malformation | 4 | 1 4.0|
Peridontal Tissue, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 | 6 1.8|
Myocardium, Fibrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 1 1 2 1 | 14 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 3.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 4| 3 3.7|
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 1| 3| 7| 6| 2| 2| 2| 2| 5| 2| 2| 3| 4| 8| 4| 2| 2| 4| 0| 3| 2| 2| 2| |
| 6| 9| 9| 0| 5| 9| 9| 9| 9| 9| 6| 9| 9| 0| 2| 9| 8| 9| 1| 2| 9| 0| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 | 4 1.5|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 3 3.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 3 1 2 2 2 2 2 2 2 2 3 1 2| 24 1.8|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 3 2 4 2 2 4 | 19 2.4|
Interstitial Cell, Hyperplasia | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 1| 3| 7| 6| 2| 2| 2| 2| 5| 2| 2| 3| 4| 8| 4| 2| 2| 4| 0| 3| 2| 2| 2| |
| 6| 9| 9| 0| 5| 9| 9| 9| 9| 9| 6| 9| 9| 0| 2| 9| 8| 9| 1| 2| 9| 0| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Deep Cervical, Ectasia | | 1 3.0|
Deep Cervical, Inflammation | 4 | 1 4.0|
Pancreatic, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + M M M M M M M + + M M + + M M M M M M M| 7 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M M M M M M M M M M M M M M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + M + + M M M M| 41 |
Angiectasis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 3 |
Fibrosis | 2 | 1 2.0|
Necrosis | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + M + M + + + + + + M + + + + + + + M + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 2 4.0|
Metaplasia, Squamous | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 4 4 X | 5 4.0|
Hyperkeratosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 1| 3| 7| 6| 2| 2| 2| 2| 5| 2| 2| 3| 4| 8| 4| 2| 2| 4| 0| 3| 2| 2| 2| |
| 6| 9| 9| 0| 5| 9| 9| 9| 9| 9| 6| 9| 9| 0| 2| 9| 8| 9| 1| 2| 9| 0| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 | 4 3.0|
Hemorrhage | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 4 4 | 2 4.0|
Inflammation, Suppurative | 3 | 2 3.5|
Epiglottis, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 3.0|
Inflammation, Chronic | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 4 | 2 3.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 3 2.0|
Alveolus, Proteinosis | | 1 2.0|
Interstitium, Fibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 4 3 3 3 | 6 3.2|
Inflammation, Suppurative | 4 2 1 2 1 4 2 | 10 2.2|
Glands, Dilatation | 1 1 | 2 1.0|
Goblet Cell, Hyperplasia | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 3 3 1 1 2 3 1 3 3 1| 25 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 6| 2| 1| 3| 7| 6| 2| 2| 2| 2| 5| 2| 2| 3| 4| 8| 4| 2| 2| 4| 0| 3| 2| 2| 2| |
| 6| 9| 9| 0| 5| 9| 9| 9| 9| 9| 6| 9| 9| 0| 2| 9| 8| 9| 1| 2| 9| 0| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Respiratory Epithelium, Hyperplasia | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
Cyst | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Eye | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + M M + M + + + + + + + + + M + + + + + + + M| 41 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 4.0|
Nephropathy, Chronic | 2 2 2 2 1 2 4 3 3 1 2 1 4 4 1 1 1 2 3 2 4 3 4 1 3| 50 2.3|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 4 | 2 3.0|
Cortex, Renal Tubule, Hyperplasia | 2 4 1 | 3 2.3|
Papilla, Mineralization | 1 1 | 8 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 5| 6| 5| 5| 6| 0| 6| 5| 7| 5| 7| 5| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 0| 8| 6| 9| 2| 5| 6| 3| 6| 9| 0| 0| 1| 9| 3| 5| 0| 0| 3|
| 0| 6| 9| 9| 0| 9| 9| 4| 5| 0| 9| 6| 1| 4| 5| 0| 5| 9| 1| 3| 0| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hemorrhage | 4 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + A + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + A + + + + A + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Basophilic Focus | X X X X X X|
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 4 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | 4 4 4 4 4 |
Necrosis | 4 4 4 |
Vacuolization Cytoplasmic | |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Regeneration | |
|__________________________________________________________________________|
Mesentery | + + + + + |
Necrosis | 1 2 2 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Acinus, Atrophy | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 5| 6| 5| 5| 6| 0| 6| 5| 7| 5| 7| 5| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 0| 8| 6| 9| 2| 5| 6| 3| 6| 9| 0| 0| 1| 9| 3| 5| 0| 0| 3|
| 0| 6| 9| 9| 0| 9| 9| 4| 5| 0| 9| 6| 1| 4| 5| 0| 5| 9| 1| 3| 0| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Necrosis | |
Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Erosion | 3 3 |
Mineralization | |
Ulcer | |
|__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + A + + + + + + +|
Pulmonary Artery, Degeneration, | |
Mucoid | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cardiomyopathy | 3 3 3 |
Inflammation, Focal, Suppurative | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + A + + + + + + +|
Mineralization | |
Vacuolization Cytoplasmic | 1 3 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 1 4 3 2 2 3 |
Thrombosis | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 5| 6| 5| 5| 6| 0| 6| 5| 7| 5| 7| 5| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 0| 8| 6| 9| 2| 5| 6| 3| 6| 9| 0| 0| 1| 9| 3| 5| 0| 0| 3|
| 0| 6| 9| 9| 0| 9| 9| 4| 5| 0| 9| 6| 1| 4| 5| 0| 5| 9| 1| 3| 0| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Angiectasis | |
Hemorrhage | 4 |
Hyperplasia | 4 4 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Penis | + |
Necrosis | 4 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 4 4 |
Inflammation, Suppurative | 4 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Suppurative | 1 1 2 2 1 1 2 2 2 2 2 3 2 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + A + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 3 |
Germinal Epithelium, Atrophy | 4 4 4 2 4 1 |
Interstitial Cell, Hyperplasia | 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 5| 6| 5| 5| 6| 0| 6| 5| 7| 5| 7| 5| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 0| 8| 6| 9| 2| 5| 6| 3| 6| 9| 0| 0| 1| 9| 3| 5| 0| 0| 3|
| 0| 6| 9| 9| 0| 9| 9| 4| 5| 0| 9| 6| 1| 4| 5| 0| 5| 9| 1| 3| 0| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Pancreatic, Hemorrhage | 4 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M + M M + M M M + M M M + + M M M M M|
Hemorrhage | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M + M M M + M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + A + M + + + + +|
Angiectasis | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Accessory Spleen | X X |
Fibrosis | X 3 3 3 |
Hemorrhage | |
Necrosis | 3 4 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + A + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Galactocele | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | 4 3 3 3 |
Prepuce, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 5| 6| 5| 5| 6| 0| 6| 5| 7| 5| 7| 5| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 0| 8| 6| 9| 2| 5| 6| 3| 6| 9| 0| 0| 1| 9| 3| 5| 0| 0| 3|
| 0| 6| 9| 9| 0| 9| 9| 4| 5| 0| 9| 6| 1| 4| 5| 0| 5| 9| 1| 3| 0| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + A + + + + + + +|
Compression | 2 X X |
Gliosis | 3 |
Hemorrhage | 3 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + A + + + + + + +|
Foreign Body | 4 |
Inflammation, Suppurative | |
Epiglottis, Hyperplasia | |
Epiglottis, Metaplasia, Squamous | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 1 1 |
Inflammation, Suppurative | 4 |
Alveolar Epithelium, Hyperplasia | 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 2|
Artery, Mineralization | |
Artery, Thrombosis | 4 |
Interstitium, Fibrosis | 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +|
Foreign Body | 3 3 |
Inflammation, Suppurative | 3 3 3 2 2 2 1|
Glands, Dilatation | 1 2 2 |
Goblet Cell, Hyperplasia | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 3 2 2 3 4 4 3 3 3 4 4 2 2 1 3 3 1 3 2 2 3 4 3|
Respiratory Epithelium, Hyperplasia | 3 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | 1 1 |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 5| 6| 5| 5| 6| 0| 6| 5| 7| 5| 7| 5| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 0| 8| 6| 9| 2| 5| 6| 3| 6| 9| 0| 0| 1| 9| 3| 5| 0| 0| 3|
| 0| 6| 9| 9| 0| 9| 9| 4| 5| 0| 9| 6| 1| 4| 5| 0| 5| 9| 1| 3| 0| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +|
Glands, Cyst | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + A + + + + + + +|
Anterior Chamber, Inflammation, | |
Suppurative | |
Cornea, Inflammation, Suppurative | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + M M + + + M + + + + + + + + + M A + M + M + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Nephropathy, Chronic | 4 2 4 3 3 3 1 4 3 3 4 2 3 3 3 3 3 2 2 3 2 3 3 2|
Pigmentation | 2 |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 2 4 4 4 3 3 2|
Cortex, Renal Tubule, Hyperplasia | 2 2 |
Cortex, Renal Tubule, Necrosis | 3 |
Papilla, Mineralization | 2 2 2 2 1 1 1 1 2 2 1 1 2 2 2 1 2 |
Pelvis, Inflammation, Suppurative | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 1 |
Renal Tubule, Pigmentation | 4 4|
|__________________________________________________________________________|
Urethra | |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 2 |
__________________________________________|__________________________________________________________________________
Page 79
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 6| 7| 3| 6| 6| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 7| 2| 8| 9| 2| 6| 4| 9| 2| 5| 3| 2| 4| 4| 2| 3| 2| 1| 3| 3| 1| 2| |
| 2| 0| 9| 0| 9| 1| 7| 9| 1| 6| 6| 9| 0| 0| 9| 2| 6| 9| 1| 1| 6| 7| 0| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A + + + + + + + A + + + + + + + A + A + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + A + + + + + + + A + A + + + +| 43 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X | 15 |
Clear Cell Focus | X X X X X X | 11 |
Degeneration, Cystic | | 1 4.0|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | 4 4 4 4 4 4 | 11 4.0|
Necrosis | | 3 4.0|
Vacuolization Cytoplasmic | 4 4 | 2 4.0|
Bile Duct, Dilatation | 4| 1 4.0|
Bile Duct, Hyperplasia | | 1 3.0|
Hepatocyte, Regeneration | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 10 |
Necrosis | 3 3 2 2 3 | 10 2.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 6| 7| 3| 6| 6| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 7| 2| 8| 9| 2| 6| 4| 9| 2| 5| 3| 2| 4| 4| 2| 3| 2| 1| 3| 3| 1| 2| |
| 2| 0| 9| 0| 9| 1| 7| 9| 1| 6| 6| 9| 0| 0| 9| 2| 6| 9| 1| 1| 6| 7| 0| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 2 2 | 2 2.0|
Necrosis | 1 | 1 1.0|
Ulcer | 4 4 | 3 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 4| 3 3.3|
Mineralization | 2| 1 2.0|
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Tongue | + + + | 3 |
Epithelium, Hyperplasia | 2 3 4 | 3 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pulmonary Artery, Degeneration, | | |
Mucoid | 4| 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 | 4 2.8|
Inflammation, Focal, Suppurative | 4 | 1 4.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 3| 6 2.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 4 3 3 | 11 2.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 6| 7| 3| 6| 6| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 7| 2| 8| 9| 2| 6| 4| 9| 2| 5| 3| 2| 4| 4| 2| 3| 2| 1| 3| 3| 1| 2| |
| 2| 0| 9| 0| 9| 1| 7| 9| 1| 6| 6| 9| 0| 0| 9| 2| 6| 9| 1| 1| 6| 7| 0| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thrombosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 | 1 1.0|
Hemorrhage | 4 | 2 4.0|
Hyperplasia | 3 | 4 3.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 | 7 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Penis | | 1 |
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 3 3.7|
Inflammation, Suppurative | 4 4 4 | 4 4.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 2 4 3 3 2 2 2 3 2 2 3 4| 27 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 6| 7| 3| 6| 6| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 7| 2| 8| 9| 2| 6| 4| 9| 2| 5| 3| 2| 4| 4| 2| 3| 2| 1| 3| 3| 1| 2| |
| 2| 0| 9| 0| 9| 1| 7| 9| 1| 6| 6| 9| 0| 0| 9| 2| 6| 9| 1| 1| 6| 7| 0| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 1 3.0|
Germinal Epithelium, Atrophy | 2 2 3 3 2 2 4 1 1 4 4 4| 18 2.8|
Interstitial Cell, Hyperplasia | 3 3 3 | 7 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 15 |
Pancreatic, Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M + M M M M + M M M M M M M M M M M M M M| 9 |
Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M + M M M M M M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + + + + M + + +| 46 |
Angiectasis | 4| 1 4.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | X X | 4 |
Fibrosis | 4 3 4| 7 3.3|
Hemorrhage | 4 | 1 4.0|
Necrosis | 4 4 | 5 3.6|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + M + + +| 46 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 6| 7| 3| 6| 6| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 7| 2| 8| 9| 2| 6| 4| 9| 2| 5| 3| 2| 4| 4| 2| 3| 2| 1| 3| 3| 1| 2| |
| 2| 0| 9| 0| 9| 1| 7| 9| 1| 6| 6| 9| 0| 0| 9| 2| 6| 9| 1| 1| 6| 7| 0| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | 4 4 | 3 4.0|
Hyperkeratosis | 3 4 | 6 3.3|
Prepuce, Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | 3 2 | 5 2.3|
Gliosis | | 1 3.0|
Hemorrhage | 2 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Foreign Body | | 1 4.0|
Inflammation, Suppurative | 1 | 1 1.0|
Epiglottis, Hyperplasia | 2 | 1 2.0|
Epiglottis, Metaplasia, Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 2 2 2 | 5 1.6|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 6| 7| 3| 6| 6| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 7| 2| 8| 9| 2| 6| 4| 9| 2| 5| 3| 2| 4| 4| 2| 3| 2| 1| 3| 3| 1| 2| |
| 2| 0| 9| 0| 9| 1| 7| 9| 1| 6| 6| 9| 0| 0| 9| 2| 6| 9| 1| 1| 6| 7| 0| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 | 5 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 3 | 8 2.0|
Artery, Mineralization | 4| 1 4.0|
Artery, Thrombosis | | 1 4.0|
Interstitium, Fibrosis | 3 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 3 3 | 4 3.0|
Inflammation, Suppurative | 2 3 2 1 | 11 2.2|
Glands, Dilatation | 2 2 2 2| 7 1.9|
Goblet Cell, Hyperplasia | 3 | 2 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 3 3 3 3 4 3 4 3 3 4 4 4 4 2 4 3 2 3 4 4 4| 45 3.0|
Respiratory Epithelium, Hyperplasia | 2 2 | 4 2.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 3 1.3|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Glands, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Anterior Chamber, Inflammation, | | |
Suppurative | 3| 1 3.0|
Cornea, Inflammation, Suppurative | 2| 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Zymbal's Gland | M + + M + + M + M + + + + + + + + + + + + + + + +| 39 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 6| 6| 7| 3| 6| 6| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 7| 2| 8| 9| 2| 6| 4| 9| 2| 5| 3| 2| 4| 4| 2| 3| 2| 1| 3| 3| 1| 2| |
| 2| 0| 9| 0| 9| 1| 7| 9| 1| 6| 6| 9| 0| 0| 9| 2| 6| 9| 1| 1| 6| 7| 0| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
300 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 3 3 1 4 4 3 4 3 3 4 4 3 3 4 3 3 2 3 1 2 4 1 3 4 4| 49 2.9|
Pigmentation | | 1 2.0|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 4 2 | 9 3.1|
Cortex, Renal Tubule, Hyperplasia | 1 3 3 4 4| 7 2.7|
Cortex, Renal Tubule, Necrosis | | 1 3.0|
Papilla, Mineralization | 2 2 2 1 2 2 2 1 1 1 1 | 28 1.6|
Pelvis, Inflammation, Suppurative | 2| 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 1 2 2| 6 1.3|
Renal Tubule, Pigmentation | | 2 4.0|
|__________________________________________________________________________|____________|
Urethra | +| 1 |
Transitional Epithelium, Hyperplasia | 4| 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Transitional Epithelium, Hyperplasia | 4| 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 6| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 4| 6| 5| 3| 9| 3| 5| 3| 8| 3| 2| 2| 3| 5| 3| 3| 2| 8| 4| 2| 3| 2| 9| 3| 0|
| 8| 6| 5| 0| 8| 5| 6| 9| 2| 1| 9| 5| 0| 4| 0| 0| 4| 1| 8| 9| 0| 9| 8| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + A + +|
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + A + +|
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X X X |
Degeneration, Cystic | 4 3 |
Eosinophilic Focus | |
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | 4 4 |
Necrosis | |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | |
|__________________________________________________________________________|
Mesentery | + + + |
Necrosis | 3 3 |
Thrombosis | 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 6| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 4| 6| 5| 3| 9| 3| 5| 3| 8| 3| 2| 2| 3| 5| 3| 3| 2| 8| 4| 2| 3| 2| 9| 3| 0|
| 8| 6| 5| 0| 8| 5| 6| 9| 2| 1| 9| 5| 0| 4| 0| 0| 4| 1| 8| 9| 0| 9| 8| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 4 |
Ulcer | 4 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Vacuolization Cytoplasmic | 4 2 2 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 6| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 4| 6| 5| 3| 9| 3| 5| 3| 8| 3| 2| 2| 3| 5| 3| 3| 2| 8| 4| 2| 3| 2| 9| 3| 0|
| 8| 6| 5| 0| 8| 5| 6| 9| 2| 1| 9| 5| 0| 4| 0| 0| 4| 1| 8| 9| 0| 9| 8| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 1 1 1 2 2 2 1 3 2 2 2 2 1 1 2 2 1|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 3 |
Germinal Epithelium, Atrophy | 4 3 1 4 4 4 4 3 3 4 4 |
Interstitial Cell, Hyperplasia | 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Deep Cervical, Inflammation, | |
Suppurative | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M M M M + + + M + M M M M M M M + + M +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 6| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 4| 6| 5| 3| 9| 3| 5| 3| 8| 3| 2| 2| 3| 5| 3| 3| 2| 8| 4| 2| 3| 2| 9| 3| 0|
| 8| 6| 5| 0| 8| 5| 6| 9| 2| 1| 9| 5| 0| 4| 0| 0| 4| 1| 8| 9| 0| 9| 8| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M + M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M M + M + + + + + + + + + + + + M M +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 2 |
Hemorrhage | 4 4 4 |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + M + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Epithelium, Cyst, Squamous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | 3 |
Inflammation, Granulomatous | 3 3 |
Ulcer | 3 4 |
Subcutaneous Tissue, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hemorrhage | 4 |
|__________________________________________________________________________|
Skeletal Muscle | + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 6| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 4| 6| 5| 3| 9| 3| 5| 3| 8| 3| 2| 2| 3| 5| 3| 3| 2| 8| 4| 2| 3| 2| 9| 3| 0|
| 8| 6| 5| 0| 8| 5| 6| 9| 2| 1| 9| 5| 0| 4| 0| 0| 4| 1| 8| 9| 0| 9| 8| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 |
Epiglottis, Hyperplasia | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 4 4 |
Alveolar Epithelium, Metaplasia, | |
Squamous | 4 3 |
Alveolus, Foreign Body | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 4 |
Interstitium, Fibrosis | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Hemorrhage | 4 |
Inflammation, Chronic | 1 2 |
Inflammation, Suppurative | |
Glands, Dilatation | 1 1 3 1 3 |
Goblet Cell, Hyperplasia | 1 2 3 2 1 3 3 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 2 4 4 4 3 4 3 4 4 3 4 2 3 4 2 4 3 3 4 4 4 4 4|
Olfactory Epithelium, Hyperplasia, | |
Basal Cell | 3 |
Respiratory Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 6| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 4| 6| 5| 3| 9| 3| 5| 3| 8| 3| 2| 2| 3| 5| 3| 3| 2| 8| 4| 2| 3| 2| 9| 3| 0|
| 8| 6| 5| 0| 8| 5| 6| 9| 2| 1| 9| 5| 0| 4| 0| 0| 4| 1| 8| 9| 0| 9| 8| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 |
Mesothelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Anterior Chamber, Cornea, | |
Inflammation | 2 |
Anterior Chamber, Cornea, | |
Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + M + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 4 2 2 3 2 4 3 4 4 4 4 1 4 4 4 4 4 4 4 3 4 4 3|
Cortex, Infarct | |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 3 1 3 3 3 2 2 3 3 3|
Cortex, Renal Tubule, Hyperplasia | 1 4 2 4 3 2 |
Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 2 2 2 2|
|__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 3 |
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 6| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 4| 6| 5| 3| 9| 3| 5| 3| 8| 3| 2| 2| 3| 5| 3| 3| 2| 8| 4| 2| 3| 2| 9| 3| 0|
| 8| 6| 5| 0| 8| 5| 6| 9| 2| 1| 9| 5| 0| 4| 0| 0| 4| 1| 8| 9| 0| 9| 8| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 1 2 2 |
__________________________________________|__________________________________________________________________________
Page 93
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 2| 2| 2| 2| 3| 3| 6| 8| 3| 1| 1| 5| 2| 2| 1| 6| 3| 8| 3| 2| 1| 9| |
| 9| 0| 5| 9| 9| 9| 9| 7| 0| 2| 4| 0| 8| 2| 0| 9| 9| 6| 3| 0| 3| 0| 9| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + A + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + A + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + A + + A + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + A + + + + + + +| 47 |
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + A + + + + + + +| 46 |
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + A + + A + + + +| 45 |
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X| 17 |
Clear Cell Focus | X X X X X X| 9 |
Degeneration, Cystic | 2 | 3 3.0|
Eosinophilic Focus | X X | 2 |
Fatty Change | | 1 2.0|
Hepatodiaphragmatic Nodule | 4 4 4 | 5 4.0|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 4 | 1 4.0|
Bile Duct, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Necrosis | 3 3 2 | 5 2.8|
Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 2| 2| 2| 2| 3| 3| 6| 8| 3| 1| 1| 5| 2| 2| 1| 6| 3| 8| 3| 2| 1| 9| |
| 9| 0| 5| 9| 9| 9| 9| 7| 0| 2| 4| 0| 8| 2| 0| 9| 9| 6| 3| 0| 3| 0| 9| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Artery, Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 4 3 | 4 3.5|
Ulcer | 4 4 | 4 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 3 1 | 7 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 3 2.3|
Vacuolization Cytoplasmic | 2 4 2 2| 9 2.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 4 3 2 3 | 9 3.2|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 2| 2| 2| 2| 3| 3| 6| 8| 3| 1| 1| 5| 2| 2| 1| 6| 3| 8| 3| 2| 1| 9| |
| 9| 0| 5| 9| 9| 9| 9| 7| 0| 2| 4| 0| 8| 2| 0| 9| 9| 6| 3| 0| 3| 0| 9| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Hyperplasia | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 2 1 2 2 2 1 2 2 2 2| 27 1.7|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 1 3.0|
Germinal Epithelium, Atrophy | 1 4 4 4 4 1 4 4 3| 20 3.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 2| 2| 2| 2| 3| 3| 6| 8| 3| 1| 1| 5| 2| 2| 1| 6| 3| 8| 3| 2| 1| 9| |
| 9| 0| 5| 9| 9| 9| 9| 7| 0| 2| 4| 0| 8| 2| 0| 9| 9| 6| 3| 0| 3| 0| 9| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Interstitial Cell, Hyperplasia | 3 3 3 | 7 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Deep Cervical, Inflammation, | | |
Suppurative | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + M + M M M M M M + + M M M + M M M + + +| 21 |
Hyperplasia, Lymphoid | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 3 3 3| 4 2.8|
Hemorrhage | | 3 4.0|
Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 1 4.0|
Epithelium, Cyst, Squamous | 4 | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 2| 2| 2| 2| 3| 3| 6| 8| 3| 1| 1| 5| 2| 2| 1| 6| 3| 8| 3| 2| 1| 9| |
| 9| 0| 5| 9| 9| 9| 9| 7| 0| 2| 4| 0| 8| 2| 0| 9| 9| 6| 3| 0| 3| 0| 9| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 | 1 4.0|
Hyperkeratosis | | 1 3.0|
Inflammation, Granulomatous | | 2 3.0|
Ulcer | | 2 3.5|
Subcutaneous Tissue, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 | 3 3.7|
Hemorrhage | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 | 1 4.0|
Inflammation, Chronic | 2 2 | 3 2.0|
Epiglottis, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 3 1 1 | 4 1.5|
Inflammation, Suppurative | 4 3 | 2 3.5|
Alveolar Epithelium, Hyperplasia | 4 1 4 4 | 6 3.5|
Alveolar Epithelium, Metaplasia, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 2| 2| 2| 2| 3| 3| 6| 8| 3| 1| 1| 5| 2| 2| 1| 6| 3| 8| 3| 2| 1| 9| |
| 9| 0| 5| 9| 9| 9| 9| 7| 0| 2| 4| 0| 8| 2| 0| 9| 9| 6| 3| 0| 3| 0| 9| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Squamous | 3 3 | 4 3.3|
Alveolus, Foreign Body | 4 | 2 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 1 1 | 8 1.8|
Interstitium, Fibrosis | 2 3 1 2 | 6 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 3 | 3 3.0|
Hemorrhage | | 1 4.0|
Inflammation, Chronic | 2 1 | 4 1.5|
Inflammation, Suppurative | 2 2 3 3| 4 2.5|
Glands, Dilatation | 1 3 2 2 1 2 2 1 2 2| 15 1.8|
Goblet Cell, Hyperplasia | 2 1 2 2 1 1 3 | 15 1.9|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 4 4 4 3 4 4 4 4 4 3 4 4 3 4 4 3 4 3 3 4 4 4 4 4 4| 50 3.6|
Olfactory Epithelium, Hyperplasia, | | |
Basal Cell | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 1 3 | 3 2.3|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 2 1 | 7 1.3|
Mesothelium, Hyperplasia | 3 | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Anterior Chamber, Cornea, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 90004-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROPYLENE GLYCOL MONO-T-BUTYL ETHER Date: 03/04/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:25:09
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 2| 2| 2| 2| 3| 3| 6| 8| 3| 1| 1| 5| 2| 2| 1| 6| 3| 8| 3| 2| 1| 9| |
| 9| 0| 5| 9| 9| 9| 9| 7| 0| 2| 4| 0| 8| 2| 0| 9| 9| 6| 3| 0| 3| 0| 9| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Inflammation | | 1 2.0|
Anterior Chamber, Cornea, | | |
Inflammation, Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + M + + + + + + M +| 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 4 4 4 3 4 4 4 3 3 4 3 3 3 2 4 3 4 3 3 4 3 4 4 4 4| 50 3.5|
Cortex, Infarct | 3 4 | 2 3.5|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 4 2 3 2 2 1 4| 17 2.6|
Cortex, Renal Tubule, Hyperplasia | 1 1 3 4 2 2 2 1 2 1 4 2 4| 19 2.4|
Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 1 1 1 1 2 2| 15 1.4|
|__________________________________________________________________________|____________|
Urethra | + | 2 |
Inflammation, Suppurative | | 1 3.0|
Transitional Epithelium, Hyperplasia | 4 | 2 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 3 1 | 6 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
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