TDMS Study 90004-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest PROPYLENE GLYCOL MONO-T-BUTYL ETHER DATE: 11/14/01
EXPERIMENT: 90004 TEST: 07 TIME: 10:00:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C90004
PATHOLOGIST: RENNE, ROGER CAS: 57018-52-7
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest PROPYLENE GLYCOL MONO-T-BUTYL ETHER DATE: 11/14/01
EXPERIMENT: 90004 TEST: 07 TIME: 10:00:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C90004
PATHOLOGIST: RENNE, ROGER CAS: 57018-52-7
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 296 409 458 465 539 604 625 630 631 639 |
| 642 642 646 655 655 656 668 681 684 712 |
| 712 718 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 464 509 509 513 569 591 621 642 642 642 |
| 648 656 666 675 689 697 705 709 713 719 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 9 361 431 509 509 537 550 550 561 565 |
| 565 590 593 605 611 619 621 634 642 646 |
| 646 652 656 656 670 681 684 690 696 697 |
| 709 716 718 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 254 509 518 537 550 582 598 612 616 631 |
| 635 635 639 648 648 655 656 662 663 666 |
| 681 683 684 696 698 716 724 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 96.0 92.0 90.0 88.0 68.0 54.0 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 88.0 76.0 58.0 |
| | |
| | |
|300 PPM | 98.0 98.0 98.0 96.0 96.0 94.0 88.0 72.0 52.0 32.0 |
| | |
| | |
|1200 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 92.0 86.0 62.0 44.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 75 PPM 300 PPM 1200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.0% 58.0% 32.0% 44.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.358 P=0.727N P=0.031 P=0.435 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 612.6 633.6 597.1 625.8 |
|NATURAL DEATHS (C) | (22.6) (17.2) (22.8) (17.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 675.5 688.9 639.3 671.2 |
|(STANDARD ERROR) | (13.2) ( 9.8) (17.7) (12.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 171 284 380 415 537 558 587 593 625 642 |
| 670 684 687 702 708 715 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 410 621 642 642 656 656 660 676 681 683 |
| 684 708 722 725 726 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 471 507 509 523 528 559 576 593 610 617 |
| 634 637 646 646 670 682 692 698 698 709 |
| 712 712 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 283 519 550 555 586 617 642 669 675 684 |
| 684 717 722 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 96.0 92.0 92.0 90.0 84.0 80.0 66.0 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 100.0 98.0 98.0 98.0 98.0 86.0 68.0 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 90.0 84.0 72.0 56.0 |
| | |
| | |
|1200 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 90.0 86.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 75 PPM 300 PPM 1200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 68.0% 56.0% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.515N P=0.801N P=0.419 P=0.602N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 569.2 663.6 619.5 616.4 |
|NATURAL DEATHS (C) | (39.6) (18.9) (16.3) (31.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 675.3 708.8 681.4 698.2 |
|(STANDARD ERROR) | (17.1) ( 7.4) (10.5) (11.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
75 PPM = 2
300 PPM = 3
1200 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 4 1 2
| 3 4 1 3 1 2 2
| 3 1 3 11 22 4
| 1 2 1 4 2
90 + 3 1 4 2 4 2 1
| 3 3 4 241 21
P | 3 3 4 42112
E | 4 11
R 80 + 22
C | 3 3 22
E | 3 3 4111 22
N | 33 2 2
T 70 + 33 44 22
| 1 1 22
S | 3 33 4 41 1 22
U | 33 44 1 12
R 60 + 4 4 22
V | 33 112 2
I | 4 4 11 1
V | 3 3
A 50 + 3 3 4 4
L | 44
| 333 4 4
|
40 + 3 3
| 33
| 33
| 3 3
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 23 obs hidden.
PROPYLENE GLYCOL MONO-T-BUTYL ETHER
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
75 PPM = 2
300 PPM = 3
1200 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 2 3
|
| 1 1 2 3 3 4 2
| 1 1 4 4 2 2
95 +
| 1 1 3 3 44
| 1 331 4 4 2 2
|
90 + 31 1 4 4
|
P | 1 31 4 4 2 2
E | 31 1 4 242
R 85 +
C | 1 3 1 422
E | 331 1 44
N |
T 80 + 3 31 1
|
S | 1 1 24
U | 3 3 11 242
R 75 +
V | 1 1
I | 3 3 11 4 4
V |
A 70 + 3 3 11
L |
| 33 2 2
| 33 1 1
65 +
|
| 3 3
|
60 +
|
|
| 3 3
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.