Nonneoplastic Lesions By Individual Animal
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 93-83-4
Lock Date: 01/02/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 5| 6| 6| 5| 4| 5| 7| 7| 6| 7| 4| 7| 4| 7| 6| 5| 7| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 9| 2| 2| 6| 5| 8| 3| 7| 2| 2| 9| 2| 9| 2| 6| 2| 9| 1| 2| 4| 2| 2| 2|
| 1| 8| 8| 3| 4| 8| 3| 6| 7| 9| 8| 8| 6| 8| 7| 8| 2| 8| 2| 3| 8| 7| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + A + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | A + + A A A + + A + + + A + A + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | A + + A A A + A A + + + A + A + + + A A + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A A A + A A + + + + + A + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A A A + + A + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X|
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 3 |
Inflammation, Chronic Active | 3 1 1 1 1 1|
Mixed Cell Focus | X |
Necrosis | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 2 2 1 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 2 2 2 2 2 2 2|
Degeneration | |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Vacuolization Cytoplasmic | 2 1 1|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 5| 6| 6| 5| 4| 5| 7| 7| 6| 7| 4| 7| 4| 7| 6| 5| 7| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 9| 2| 2| 6| 5| 8| 3| 7| 2| 2| 9| 2| 9| 2| 6| 2| 9| 1| 2| 4| 2| 2| 2|
| 1| 8| 8| 3| 4| 8| 3| 6| 7| 9| 8| 8| 6| 8| 7| 8| 2| 8| 2| 3| 8| 7| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + M + + + + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Cyst | 2 2 3 2 3 2 |
Pars Distalis, Angiectasis | 3 3 3 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ultimobranchial Cyst | 2 2 |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic Active | 1 1 3 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | 4 4 |
__________________________________________________________________________|
Oviduct | + |
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Vagina | |
Hypertrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 5| 6| 6| 5| 4| 5| 7| 7| 6| 7| 4| 7| 4| 7| 6| 5| 7| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 9| 2| 2| 6| 5| 8| 3| 7| 2| 2| 9| 2| 9| 2| 6| 2| 9| 1| 2| 4| 2| 2| 2|
| 1| 8| 8| 3| 4| 8| 3| 6| 7| 9| 8| 8| 6| 8| 7| 8| 2| 8| 2| 3| 8| 7| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Dilatation | 3 2 2 2|
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 2 |
Skin, Site of Application, | |
Hyperkeratosis | 1 |
Skin, Site of Application, | |
Hyperplasia | 2 1 1 |
Skin, Site of Application, | |
Inflammation, Chronic Active | 2 2 |
Skin, Site of Application, | |
Parakeratosis | 2 2 |
Skin, Site of Application, Ulcer | 1 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosclerosis | 3 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Mineralization | 1 |
Retina, Degeneration | 3 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | |
Cyst | 3 |
Mineralization | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 |
Pigmentation, Hemosiderin | 1 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 5| 6| 6| 5| 4| 5| 7| 7| 6| 7| 4| 7| 4| 7| 6| 5| 7| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 9| 2| 2| 6| 5| 8| 3| 7| 2| 2| 9| 2| 9| 2| 6| 2| 9| 1| 2| 4| 2| 2| 2|
| 1| 8| 8| 3| 4| 8| 3| 6| 7| 9| 8| 8| 6| 8| 7| 8| 2| 8| 2| 3| 8| 7| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 5| 7| 6| 6| 7| 7| 7| 6| 6| 6| 6| 6| 2| 4| 5| 6| 7| 6| 7| |
DAY ON TEST | 2| 7| 2| 6| 6| 3| 4| 0| 3| 1| 2| 2| 2| 4| 9| 0| 9| 7| 9| 2| 7| 1| 2| 3| 1| |
| 8| 6| 9| 0| 2| 5| 5| 6| 5| 0| 8| 8| 8| 1| 5| 2| 4| 9| 6| 9| 1| 4| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Foreign Body | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A A A + + A + + + + + + + + + + + + + A + + + +| 38 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A A A + + A + + + + + + A A A + A A + A + + + +| 29 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + A + + A + A + + + +| 36 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A A + + + + + A + + + + A + + + A + A + + + +| 36 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X| 18 |
Hepatodiaphragmatic Nodule | X X X X X | 7 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 | 13 1.2|
Mixed Cell Focus | | 1 |
Necrosis | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 3 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Inflammation, Chronic Active | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 2| 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 3| 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 2 1 2 2| 18 1.3|
Thrombosis | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 5| 7| 6| 6| 7| 7| 7| 6| 6| 6| 6| 6| 2| 4| 5| 6| 7| 6| 7| |
DAY ON TEST | 2| 7| 2| 6| 6| 3| 4| 0| 3| 1| 2| 2| 2| 4| 9| 0| 9| 7| 9| 2| 7| 1| 2| 3| 1| |
| 8| 6| 9| 0| 2| 5| 5| 6| 5| 0| 8| 8| 8| 1| 5| 2| 4| 9| 6| 9| 1| 4| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | 1 2 2 2 2 1 2 2 2 2 2 3 2 2| 25 1.9|
Degeneration | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 3 1 2 | 7 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + + + + M + + M + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 3 3.0|
Cyst | 2 4 | 8 2.5|
Pars Distalis, Angiectasis | 3 3 2 4 4 | 8 3.1|
Pars Distalis, Hyperplasia | 3 2 3 | 4 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Ultimobranchial Cyst | | 2 2.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 2 3.5|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1| 46 1.2|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Periovarian Tissue, Cyst | 3 | 3 3.7|
__________________________________________________________________________|____________|
Oviduct | | 1 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Hypertrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 5| 7| 6| 6| 7| 7| 7| 6| 6| 6| 6| 6| 2| 4| 5| 6| 7| 6| 7| |
DAY ON TEST | 2| 7| 2| 6| 6| 3| 4| 0| 3| 1| 2| 2| 2| 4| 9| 0| 9| 7| 9| 2| 7| 1| 2| 3| 1| |
| 8| 6| 9| 0| 2| 5| 5| 6| 5| 0| 8| 8| 8| 1| 5| 2| 4| 9| 6| 9| 1| 4| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 2 | 3 2.3|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + M M + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 2 1 1 1 1 | 9 1.7|
Galactocele | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | | 2 2.0|
Skin, Site of Application, | | |
Hyperkeratosis | | 1 1.0|
Skin, Site of Application, | | |
Hyperplasia | | 3 1.3|
Skin, Site of Application, | | |
Inflammation, Chronic Active | | 2 2.0|
Skin, Site of Application, | | |
Parakeratosis | | 2 2.0|
Skin, Site of Application, Ulcer | | 3 1.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosclerosis | 3 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 2| 5 1.4|
Pigmentation, Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 5| 7| 6| 6| 7| 7| 7| 6| 6| 6| 6| 6| 2| 4| 5| 6| 7| 6| 7| |
DAY ON TEST | 2| 7| 2| 6| 6| 3| 4| 0| 3| 1| 2| 2| 2| 4| 9| 0| 9| 7| 9| 2| 7| 1| 2| 3| 1| |
| 8| 6| 9| 0| 2| 5| 5| 6| 5| 0| 8| 8| 8| 1| 5| 2| 4| 9| 6| 9| 1| 4| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Mineralization | | 1 1.0|
Retina, Degeneration | | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 2 | 1 2.0|
Cyst | | 1 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
Nephropathy | 1 3 1 | 9 1.2|
Pigmentation, Hemosiderin | 1 1 | 4 1.5|
Renal Tubule, Hyperplasia | 1 1 | 2 1.0|
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 6| 7| 5| 5| 5| 7| 6| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| 3| 6| 5|
DAY ON TEST | 8| 9| 2| 2| 2| 2| 4| 4| 2| 2| 8| 3| 7| 2| 2| 2| 2| 6| 9| 2| 2| 7| 7| 3| 4|
| 9| 7| 8| 2| 2| 8| 1| 7| 8| 8| 5| 0| 4| 8| 8| 8| 8| 2| 3| 8| 8| 9| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | A A + + A + + + A + + + A + + + + + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + A + + + + + + + + A + + + + + + +|
Inflammation, Chronic Active | 4 |
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Dilatation | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 1 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 1 |
Ulcer | 3 3 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 6| 7| 5| 5| 5| 7| 6| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| 3| 6| 5|
DAY ON TEST | 8| 9| 2| 2| 2| 2| 4| 4| 2| 2| 8| 3| 7| 2| 2| 2| 2| 6| 9| 2| 2| 7| 7| 3| 4|
| 9| 7| 8| 2| 2| 8| 1| 7| 8| 8| 5| 0| 4| 8| 8| 8| 8| 2| 3| 8| 8| 9| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 1 2 2 2 2 1 2|
Fibrosis | |
Hemorrhage | 2 |
Mineralization | |
Vacuolization Cytoplasmic | 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 1 2 2 |
Hemorrhage | |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + M + + + + + + +|
Cyst | 2 2|
Hyperplasia | 4 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Pigmentation, Lipofuscin | 2 |
Follicle, Cyst | |
Periovarian Tissue, Cyst | 3 4 4 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
Pigmentation, Hemosiderin | |
Pigmentation, Lipofuscin | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 6| 7| 5| 5| 5| 7| 6| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| 3| 6| 5|
DAY ON TEST | 8| 9| 2| 2| 2| 2| 4| 4| 2| 2| 8| 3| 7| 2| 2| 2| 2| 6| 9| 2| 2| 7| 7| 3| 4|
| 9| 7| 8| 2| 2| 8| 1| 7| 8| 8| 5| 0| 4| 8| 8| 8| 8| 2| 3| 8| 8| 9| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + M M + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Dilatation | 2 1 2 1 1 1 2 3 |
Galactocele | |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 3 3 3 2 2 3 1 3 2 2 3 1 2 2 2 3 3 3 3 3 1 2 3 3|
Skin, Site of Application, | |
Hyperkeratosis | 1 1 1 2 1 1 2 1 2 1 2 2 1 2 1 1 1 1 2 2 3|
Skin, Site of Application, | |
Hyperplasia | 3 3 2 1 2 1 2 2 3 2 2 1 1 1 3 2 2 3 2 2 2 2 2 3 3|
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 2 2 1 1 2 1 1 3 2 1 3 2 1 2 1 2 2 2 1 1 2 2|
Skin, Site of Application, | |
Parakeratosis | 2 2 1 2 2 2 2 3 2 2 3 1 2 3 |
Skin, Site of Application, Ulcer | 2 1 2 2 2 2 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Chronic Active | 1 |
Necrosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 6| 7| 5| 5| 5| 7| 6| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| 3| 6| 5|
DAY ON TEST | 8| 9| 2| 2| 2| 2| 4| 4| 2| 2| 8| 3| 7| 2| 2| 2| 2| 6| 9| 2| 2| 7| 7| 3| 4|
| 9| 7| 8| 2| 2| 8| 1| 7| 8| 8| 5| 0| 4| 8| 8| 8| 8| 2| 3| 8| 8| 9| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Mineralization | 2 |
Retinal Detachment | 4 |
Lens, Mineralization | 1 |
Retina, Degeneration | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 |
Pigmentation, Hemosiderin | 3 |
Renal Tubule, Degeneration | 3 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 2| 2| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 4| 2| 5| 6| |
DAY ON TEST | 6| 2| 6| 0| 2| 4| 7| 0| 2| 1| 4| 2| 2| 4| 4| 8| 2| 2| 5| 2| 2| 2| 8| 2| 2| |
| 7| 8| 7| 8| 8| 4| 0| 2| 8| 9| 5| 8| 8| 6| 4| 5| 8| 8| 8| 8| 8| 9| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + A + A A + + A A + + A A A + + + + + A + A A| 31 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + A + + A A A + + + + + A A + A| 38 |
Inflammation, Chronic Active | | 1 4.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + A A + + + + + + + + A A| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X | 15 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 3 |
Hepatodiaphragmatic Nodule | X X X X X X X X X| 14 |
Inflammation, Chronic Active | 1 | 7 1.0|
Mixed Cell Focus | X | 2 |
Vacuolization Cytoplasmic | 1 3| 3 1.7|
Bile Duct, Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Inflammation, Chronic Active | 2 | 3 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 | 5 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Suppurative | | 1 1.0|
Ulcer | 2 2 1 | 5 2.2|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 2| 2| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 4| 2| 5| 6| |
DAY ON TEST | 6| 2| 6| 0| 2| 4| 7| 0| 2| 1| 4| 2| 2| 4| 4| 8| 2| 2| 5| 2| 2| 2| 8| 2| 2| |
| 7| 8| 7| 8| 8| 4| 0| 2| 8| 9| 5| 8| 8| 6| 4| 5| 8| 8| 8| 8| 8| 9| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 2 2| 20 1.2|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2 2 2 2 1 2 | 19 1.6|
Fibrosis | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
Mineralization | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 1 2 3 2| 7 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + + + + + + + + + + + M M + M + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 3.0|
Cyst | 2 2 2| 6 1.8|
Hemorrhage | 2 | 1 2.0|
Pars Distalis, Angiectasis | 3 | 2 3.5|
Pars Distalis, Hyperplasia | 2 1 1 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Cyst | | 2 2.0|
Hyperplasia | | 1 4.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 44 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Cyst | 2 3 3| 3 2.7|
Pigmentation, Lipofuscin | | 1 2.0|
Follicle, Cyst | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 2| 2| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 4| 2| 5| 6| |
DAY ON TEST | 6| 2| 6| 0| 2| 4| 7| 0| 2| 1| 4| 2| 2| 4| 4| 8| 2| 2| 5| 2| 2| 2| 8| 2| 2| |
| 7| 8| 7| 8| 8| 4| 0| 2| 8| 9| 5| 8| 8| 6| 4| 5| 8| 8| 8| 8| 8| 9| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Periovarian Tissue, Cyst | 3 4 2 3 | 8 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 4 2 | 4 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 1| 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Pigmentation, Hemosiderin | 2 | 1 2.0|
Pigmentation, Lipofuscin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 | 1 1.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 1 1 1 | 11 1.5|
Galactocele | 4 2 | 2 3.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 1 3 2 2 2 1 2 3 3 2 3 2 2 3 3 1 1 2 3 2 2 3 3 2 | 48 2.3|
Skin, Site of Application, | | |
Hyperkeratosis | 1 3 2 1 1 1 1 1 2 1 1 2 2 1 2 1 2| 38 1.5|
Skin, Site of Application, | | |
Hyperplasia | 2 3 3 3 2 1 2 2 2 2 3 3 3 3 3 2 2 3 2 3 3 2 3 2 2| 50 2.3|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 3 2 1 1 1 2 1 1 2 1 1 2 1 1 1 2 2 1 1 1 1| 44 1.5|
Skin, Site of Application, | | |
Parakeratosis | 1 3 2 3 2 2 2 1 2 3 2 3 2 | 27 2.1|
Skin, Site of Application, Ulcer | 2 1 2 1 2 3 1 1 1 | 20 1.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 2| 2| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 7| 6| 7| 7| 4| 2| 5| 6| |
DAY ON TEST | 6| 2| 6| 0| 2| 4| 7| 0| 2| 1| 4| 2| 2| 4| 4| 8| 2| 2| 5| 2| 2| 2| 8| 2| 2| |
| 7| 8| 7| 8| 8| 4| 0| 2| 8| 9| 5| 8| 8| 6| 4| 5| 8| 8| 8| 8| 8| 9| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.0|
Inflammation, Chronic Active | 2 1 | 3 1.3|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Mineralization | | 1 2.0|
Retinal Detachment | | 1 4.0|
Lens, Mineralization | | 1 1.0|
Retina, Degeneration | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.0|
Nephropathy | 1 1 1 1 1 1 | 8 1.0|
Pigmentation, Hemosiderin | 1 1| 3 1.7|
Renal Tubule, Degeneration | | 1 3.0|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Regeneration | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Inflammation, Chronic Active | | 1 1.0|
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 5| 3| 4| 5| 6| 5| 7| 5| 7| 3| 7| 7| 5| 5| 3| 7| 5| 7| 6| 1| 5| 7| 6| 3|
DAY ON TEST | 2| 9| 5| 6| 4| 9| 6| 0| 1| 2| 0| 2| 2| 7| 3| 3| 2| 6| 2| 4| 7| 3| 2| 8| 5|
| 8| 5| 5| 3| 9| 2| 8| 9| 8| 8| 2| 8| 8| 4| 5| 1| 8| 0| 8| 4| 0| 5| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + A|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + A A A A + + + A + A + + + + + + A + + A A + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + A + + + + A + + + + + A A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + A + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Chronic Active | 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 3 |
Ulcer | 3 2 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 |
Angiectasis | 2 2 1 1 2 1 1 2 2 1 2 2 1|
Degeneration | 3 |
Hemorrhage | 2 2 |
Pigmentation, Lipofuscin | 2 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + M + + + + + M + + +|
Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 5| 3| 4| 5| 6| 5| 7| 5| 7| 3| 7| 7| 5| 5| 3| 7| 5| 7| 6| 1| 5| 7| 6| 3|
DAY ON TEST | 2| 9| 5| 6| 4| 9| 6| 0| 1| 2| 0| 2| 2| 7| 3| 3| 2| 6| 2| 4| 7| 3| 2| 8| 5|
| 8| 5| 5| 3| 9| 2| 8| 9| 8| 8| 2| 8| 8| 4| 5| 1| 8| 0| 8| 4| 0| 5| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Cyst | 2 3 2 2 |
Hemorrhage | |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 2 2 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Periovarian Tissue, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 |
Galactocele | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 3 3 2 3 2 2 3 3 2 4 3 2 3 4 3 3 3 3 3 2 2 3 2 2 2|
Skin, Site of Application, | |
Hyperkeratosis | 2 1 1 2 2 2 2 1 1 2 2 2 2 1 1|
Skin, Site of Application, | |
Hyperplasia | 3 2 2 2 3 2 3 3 2 2 3 1 2 3 3 3 3 2 3 2 2 3 3 3 2|
Skin, Site of Application, | |
Inflammation, Chronic Active | 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 5| 3| 4| 5| 6| 5| 7| 5| 7| 3| 7| 7| 5| 5| 3| 7| 5| 7| 6| 1| 5| 7| 6| 3|
DAY ON TEST | 2| 9| 5| 6| 4| 9| 6| 0| 1| 2| 0| 2| 2| 7| 3| 3| 2| 6| 2| 4| 7| 3| 2| 8| 5|
| 8| 5| 5| 3| 9| 2| 8| 9| 8| 8| 2| 8| 8| 4| 5| 1| 8| 0| 8| 4| 0| 5| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Skin, Site of Application, | |
Parakeratosis | 2 2 3 3 2 3 2 2 3 3 1 3 3 3 3 2 3 2 3 2 3 2|
Skin, Site of Application, Ulcer | 2 2 1 1 2 2 2 2 3 3 2 2 1 2 4 2 2 3 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Osteosclerosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema | |
Inflammation, Chronic Active | |
Mineralization | 1 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Mineralization | 2 |
Lens, Cataract | |
Lens, Mineralization | 3 3 |
Retina, Degeneration | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1|
Nephropathy | 4 |
Renal Tubule, Regeneration | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic Active | 1 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 5| 6| 5| 6| 3| 6| 7| 3| 1| 7| 4| 7| 4| 3| 7| 5| 5| 7| 6| 5| |
DAY ON TEST | 5| 2| 2| 2| 2| 6| 7| 1| 9| 0| 2| 2| 9| 6| 2| 1| 2| 3| 1| 2| 0| 1| 2| 3| 6| |
| 9| 8| 6| 8| 8| 3| 3| 9| 5| 5| 1| 8| 4| 9| 8| 9| 8| 4| 3| 8| 1| 8| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + A + + +| 46 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + A + A + A A + A + + A + A A + + A + A +| 28 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A A + A + + + + + + A A + + A + + +| 38 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + A + A + + + + + A + A A + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X | 11 |
Hepatodiaphragmatic Nodule | X X X X X| 11 |
Inflammation, Chronic Active | 1 1 1 1 1 | 9 1.0|
Vacuolization Cytoplasmic | | 2 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Acinus, Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Ulcer | | 2 2.5|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 2 1 1 1 | 14 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 2 1.5|
Angiectasis | 1 1 1 1 2 2 2 2 2 1 1 2 2| 26 1.5|
Degeneration | | 1 3.0|
Hemorrhage | | 2 2.0|
Pigmentation, Lipofuscin | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 5| 6| 5| 6| 3| 6| 7| 3| 1| 7| 4| 7| 4| 3| 7| 5| 5| 7| 6| 5| |
DAY ON TEST | 5| 2| 2| 2| 2| 6| 7| 1| 9| 0| 2| 2| 9| 6| 2| 1| 2| 3| 1| 2| 0| 1| 2| 3| 6| |
| 9| 8| 6| 8| 8| 3| 3| 9| 5| 5| 1| 8| 4| 9| 8| 9| 8| 4| 3| 8| 1| 8| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | 1 2 2 | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + M M + M + + + + + + + + + + + M +| 42 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 3 | 4 2.3|
Cyst | 2 | 5 2.2|
Hemorrhage | 2 | 1 2.0|
Pars Distalis, Angiectasis | 3 1 4 | 4 3.0|
Pars Distalis, Hyperplasia | 2 2 3 2 2 | 9 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 43 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Periovarian Tissue, Cyst | 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 1 2 | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 5| 6| 5| 6| 3| 6| 7| 3| 1| 7| 4| 7| 4| 3| 7| 5| 5| 7| 6| 5| |
DAY ON TEST | 5| 2| 2| 2| 2| 6| 7| 1| 9| 0| 2| 2| 9| 6| 2| 1| 2| 3| 1| 2| 0| 1| 2| 3| 6| |
| 9| 8| 6| 8| 8| 3| 3| 9| 5| 5| 1| 8| 4| 9| 8| 9| 8| 4| 3| 8| 1| 8| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 2 4 4 3 4 3 3 3 4 4 3 3 3 3 3 3 2 2 3 4 3 3 3| 49 2.9|
Skin, Site of Application, | | |
Hyperkeratosis | 1 2 2 2 1 1 2 1 1 2 1 1 2 1 2 1| 31 1.5|
Skin, Site of Application, | | |
Hyperplasia | 3 2 2 2 2 2 2 2 2 2 3 3 2 1 3 2 2 3 2 2 2 2 3 2 3| 50 2.4|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 2 3 2 2 2 2 2 1 1 1 2 2 2 3 2 2 1 2 2 1 3 2 2| 48 1.9|
Skin, Site of Application, | | |
Parakeratosis | 1 3 2 1 2 3 2 3 3 1 2 4 2 1 2 3 1 2 2 2 3| 43 2.3|
Skin, Site of Application, Ulcer | 1 2 1 1 2 3 2 3 3 2 1 3 2 3 2 2 1| 36 2.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
Osteosclerosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2| 2 2.0|
Edema | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 | 4 1.0|
Mineralization | | 1 1.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Mineralization | | 1 2.0|
Lens, Cataract | 2 | 1 2.0|
Lens, Mineralization | 1 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 5| 6| 5| 6| 3| 6| 7| 3| 1| 7| 4| 7| 4| 3| 7| 5| 5| 7| 6| 5| |
DAY ON TEST | 5| 2| 2| 2| 2| 6| 7| 1| 9| 0| 2| 2| 9| 6| 2| 1| 2| 3| 1| 2| 0| 1| 2| 3| 6| |
| 9| 8| 6| 8| 8| 3| 3| 9| 5| 5| 1| 8| 4| 9| 8| 9| 8| 4| 3| 8| 1| 8| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Retina, Degeneration | 3 4 | 4 3.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 37 1.1|
Nephropathy | 1 1 1 1 | 5 1.6|
Renal Tubule, Regeneration | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 6| 4| 4| 7| 6| 6| 7| 6| 6| 6| 7| 5| 5| 5| 4| 5| 7| 6| 7| 7| 7| 7| 4| 7| 6|
DAY ON TEST | 5| 7| 6| 2| 0| 1| 2| 7| 3| 5| 0| 9| 1| 3| 9| 4| 1| 3| 2| 2| 0| 2| 4| 2| 3|
| 3| 3| 9| 8| 3| 3| 8| 8| 7| 4| 0| 8| 7| 0| 5| 2| 2| 8| 8| 8| 7| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + A A + + A + + + + + A + A A + A + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A + + + + A A + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + A + + A + + A + A A + A + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X |
Congestion | 2 |
Degeneration | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | |
Mixed Cell Focus | X X |
Necrosis | |
Vacuolization Cytoplasmic | 3 1 2 |
Bile Duct, Hyperplasia | 3 3 |
__________________________________________________________________________|
Mesentery | |
Mineralization | |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 3 3|
Hyperkeratosis | 1 2 2 2 2 2 2|
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active | 2 2 1 3 3|
Inflammation, Suppurative | 2 3 |
Mineralization | |
Perforation | 2 3 2 3|
Ulcer | 2 2 2 |
Epithelium, Hyperplasia | 2 2 2 1 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 3 2 2 2 2|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 6| 4| 4| 7| 6| 6| 7| 6| 6| 6| 7| 5| 5| 5| 4| 5| 7| 6| 7| 7| 7| 7| 4| 7| 6|
DAY ON TEST | 5| 7| 6| 2| 0| 1| 2| 7| 3| 5| 0| 9| 1| 3| 9| 4| 1| 3| 2| 2| 0| 2| 4| 2| 3|
| 3| 3| 9| 8| 3| 3| 8| 8| 7| 4| 0| 8| 7| 0| 5| 2| 2| 8| 8| 8| 7| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 3 3 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 2 2 2 2 3 2 2 2 2 1 2 2 2 1 2 1|
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia | 2 |
Vacuolization Cytoplasmic | 2 2 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 1 3 3 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Hemorrhage | 4 |
Mineralization | 2 |
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
Hyperplasia | 3|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 |
Inflammation | |
Mineralization | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 6| 4| 4| 7| 6| 6| 7| 6| 6| 6| 7| 5| 5| 5| 4| 5| 7| 6| 7| 7| 7| 7| 4| 7| 6|
DAY ON TEST | 5| 7| 6| 2| 0| 1| 2| 7| 3| 5| 0| 9| 1| 3| 9| 4| 1| 3| 2| 2| 0| 2| 4| 2| 3|
| 3| 3| 9| 8| 3| 3| 8| 8| 7| 4| 0| 8| 7| 0| 5| 2| 2| 8| 8| 8| 7| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Chronic Active | 1 2 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 2 2 2 2 3|
Mineralization | 2 2 |
Necrosis | |
Interstitial Cell, Hyperplasia | 2 2 1 1 1 2 1 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Dilatation | 3 1 2 2 |
Galactocele | 2 3 3 |
Hyperplasia | |
Mineralization | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 2 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 6| 4| 4| 7| 6| 6| 7| 6| 6| 6| 7| 5| 5| 5| 4| 5| 7| 6| 7| 7| 7| 7| 4| 7| 6|
DAY ON TEST | 5| 7| 6| 2| 0| 1| 2| 7| 3| 5| 0| 9| 1| 3| 9| 4| 1| 3| 2| 2| 0| 2| 4| 2| 3|
| 3| 3| 9| 8| 3| 3| 8| 8| 7| 4| 0| 8| 7| 0| 5| 2| 2| 8| 8| 8| 7| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Mineralization | 2 |
Mediastinum, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
Cornea, Edema | |
Lens, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2|
Inflammation, Chronic Active | 1 |
Mineralization | 2 1 3 |
Necrosis | |
Nephropathy | 1 1 2 2 4 2 3 4 3 2 1 2 3 1 4 3 4 2 1 4 4|
Pigmentation, Hemosiderin | 1 |
Renal Tubule, Degeneration | 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
Fibrosis | |
Hemorrhage | 3 2 |
Inflammation, Chronic Active | 2 |
Mineralization | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 6| 5| 4| 6| 5| 5| 2| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 1| 5| 0| 1| 5| 9| 4| 7| 2| 2| 0| 5| 0| 4| 2| 7| 7| 9| 4| 8| 3| 3| 9| 5| 0| |
| 8| 4| 8| 4| 4| 9| 9| 4| 8| 8| 6| 9| 6| 0| 3| 1| 4| 3| 7| 0| 8| 4| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A A + + + + + + + + + + + + A + + + + A + + +| 38 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + A + + + + A + + A| 42 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + A + + + + + + + +| 41 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 3 | 2 2.0|
Basophilic Focus | X X X | 7 |
Congestion | | 1 2.0|
Degeneration | 1 | 2 1.5|
Hepatodiaphragmatic Nodule | X X X | 4 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
Mixed Cell Focus | X | 3 |
Necrosis | 2 2 | 2 2.0|
Vacuolization Cytoplasmic | 2 1 3 1 1 3 3| 10 2.0|
Bile Duct, Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 5 |
Mineralization | 2 | 1 2.0|
Fat, Inflammation, Chronic Active | 2 2 2 2| 4 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 | 3 2.3|
Duct, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 5 2.6|
Hyperkeratosis | 2 2 3 2 2 2 2 | 14 2.0|
Hyperplasia, Basal Cell | 2 1 | 2 1.5|
Inflammation, Chronic Active | 3 4 3 2 2 2 2 | 12 2.4|
Inflammation, Suppurative | 2 | 3 2.3|
Mineralization | 1 4| 2 2.5|
Perforation | | 4 2.5|
Ulcer | 2 3 2 2 2 2 2 | 10 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 6| 5| 4| 6| 5| 5| 2| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 1| 5| 0| 1| 5| 9| 4| 7| 2| 2| 0| 5| 0| 4| 2| 7| 7| 9| 4| 8| 3| 3| 9| 5| 0| |
| 8| 4| 8| 4| 4| 9| 9| 4| 8| 8| 6| 9| 6| 0| 3| 1| 4| 3| 7| 0| 8| 4| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 2 2 3 2 2 2 2 | 14 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | 3 2 2 2 3 3 4 3| 13 2.5|
Ulcer | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 1 2 3 4 2 3| 12 2.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 2 2 1 2 2 1 2 2 | 35 1.8|
Mineralization | 3 2 2 3 2 3 3| 7 2.6|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Hyperplasia | 2 2 2 | 4 2.0|
Vacuolization Cytoplasmic | 1 2 2 1 3 1 | 11 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + M + + +| 45 |
Hyperplasia | 3 1 3 2 2 1 4 4 3| 17 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Fibrosis | 2 | 1 2.0|
Hemorrhage | 4| 2 4.0|
Mineralization | | 1 2.0|
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 6| 5| 4| 6| 5| 5| 2| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 1| 5| 0| 1| 5| 9| 4| 7| 2| 2| 0| 5| 0| 4| 2| 7| 7| 9| 4| 8| 3| 3| 9| 5| 0| |
| 8| 4| 8| 4| 4| 9| 9| 4| 8| 8| 6| 9| 6| 0| 3| 1| 4| 3| 7| 0| 8| 4| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2 4 2| 8 2.8|
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 1 3 3 1 1 1 1 1 1 1 1 1 1 2 1 1 1 | 32 1.2|
Inflammation | 1 | 1 1.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 4 1 4 2 3 1 3 | 10 2.4|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 2 2 2 2 3 2 4 3 1 2| 16 2.2|
Mineralization | 2 2 | 4 2.0|
Necrosis | 4 | 1 4.0|
Interstitial Cell, Hyperplasia | 2 1 1 3 1 2 3 1 2 2 1 2 1 3 2 3 | 28 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Congestion | 2 | 1 2.0|
Ectasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 3 2 2 | 6 2.2|
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M M + + + + + + + + + + + + + + M| 45 |
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 6| 5| 4| 6| 5| 5| 2| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 1| 5| 0| 1| 5| 9| 4| 7| 2| 2| 0| 5| 0| 4| 2| 7| 7| 9| 4| 8| 3| 3| 9| 5| 0| |
| 8| 4| 8| 4| 4| 9| 9| 4| 8| 8| 6| 9| 6| 0| 3| 1| 4| 3| 7| 0| 8| 4| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Dilatation | 2 2 2 2 2 | 9 2.0|
Galactocele | 2 2 4| 6 2.7|
Hyperplasia | 4 | 1 4.0|
Mineralization | 1| 2 1.5|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 4 2 2 3 4| 9 2.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 1 | 5 1.4|
Mineralization | 1 1 2 1| 5 1.4|
Mediastinum, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Degeneration | 3 | 1 3.0|
Cornea, Edema | 2 | 1 2.0|
Lens, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 5 2.2|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | 2 1 1 2 2 2 2| 10 1.8|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 6| 5| 4| 6| 5| 5| 2| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 1| 5| 0| 1| 5| 9| 4| 7| 2| 2| 0| 5| 0| 4| 2| 7| 7| 9| 4| 8| 3| 3| 9| 5| 0| |
| 8| 4| 8| 4| 4| 9| 9| 4| 8| 8| 6| 9| 6| 0| 3| 1| 4| 3| 7| 0| 8| 4| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 4 3 4 3 4 4 3 3 3 3 4 1 3 2 1 4 4 3 4| 40 2.8|
Pigmentation, Hemosiderin | 1 1 1 2 | 5 1.2|
Renal Tubule, Degeneration | 3 | 2 2.5|
Renal Tubule, Hyperplasia | 3 | 1 3.0|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 1| 1 1.0|
Hemorrhage | 3 | 3 2.7|
Inflammation, Chronic Active | 1 | 2 1.5|
Mineralization | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 2| 6| 6| 6| 7| 7| 5| 6| 6| 6| 5| 5| 5| 4| 7| 4| 6| 5|
DAY ON TEST | 0| 2| 5| 1| 5| 8| 0| 2| 1| 1| 0| 2| 2| 8| 3| 6| 0| 6| 9| 8| 8| 2| 9| 1| 2|
| 7| 8| 9| 1| 3| 0| 6| 4| 2| 5| 7| 8| 8| 0| 6| 8| 3| 7| 1| 0| 3| 8| 7| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + A + + + + + + + A + + + + M + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 1 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 1 |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + A + + + + M + +|
Ulcer | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X |
Clear Cell Focus | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic Active | 1 1 1 |
Mixed Cell Focus | X |
Vacuolization Cytoplasmic | 1 2 1 1 3 2 |
Bile Duct, Hyperplasia | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Chronic Active | 2 3 |
Fat, Mineralization | 2 2 |
Fat, Necrosis | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2|
Acinus, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 1 2 2 |
Hyperkeratosis | 1 2 1 2 2 2 3 2 1 2 2 1 3 1 2 2 1|
Hyperplasia, Basal Cell | 1 |
Inflammation, Chronic Active | 3 2 3 2 3 3 2 2 3 2 3 3 1 3 2|
Inflammation, Suppurative | 1 |
Mineralization | |
Perforation | 3 3 2 2 2 3 3 |
Ulcer | 4 2 1 2 2 3 3 1 3|
Epithelium, Hyperplasia | 2 2 1 3 3 2 3 2 2 2 2 2 2 2 3 1|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 2| 6| 6| 6| 7| 7| 5| 6| 6| 6| 5| 5| 5| 4| 7| 4| 6| 5|
DAY ON TEST | 0| 2| 5| 1| 5| 8| 0| 2| 1| 1| 0| 2| 2| 8| 3| 6| 0| 6| 9| 8| 8| 2| 9| 1| 2|
| 7| 8| 9| 1| 3| 0| 6| 4| 2| 5| 7| 8| 8| 0| 6| 8| 3| 7| 1| 0| 3| 8| 7| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Erosion | 3 |
Mineralization | 3 3 2 |
Necrosis | 1 |
Perforation | X |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + M + +|
Inflammation, Chronic Active | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 1 2|
Mineralization | 4 4 |
Thrombosis | 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | 1 |
Degeneration | 2 |
Vacuolization Cytoplasmic | 1 2 2 1 1 1 2 3 2 1 3 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Mineralization | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + M + + + + + + + M +|
Hyperplasia | 2 2 3 4 2 4 3 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia | 1 2 |
Mineralization | 2 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 2| 6| 6| 6| 7| 7| 5| 6| 6| 6| 5| 5| 5| 4| 7| 4| 6| 5|
DAY ON TEST | 0| 2| 5| 1| 5| 8| 0| 2| 1| 1| 0| 2| 2| 8| 3| 6| 0| 6| 9| 8| 8| 2| 9| 1| 2|
| 7| 8| 9| 1| 3| 0| 6| 4| 2| 5| 7| 8| 8| 0| 6| 8| 3| 7| 1| 0| 3| 8| 7| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 1 1 2 1 2 1 1 1 1 1 2 1 1 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 3 1 2 2 |
Inflammation, Suppurative | 2 |
Mineralization | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 2 3 1 2 |
Mineralization | 1 1 |
Interstitial Cell, Hyperplasia | 1 1 1 2 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Ectasia | 2 3 2 |
Hemorrhage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Fibrosis | 2 1 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + M M + + + + + + + + + + M + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 1 2 2 |
Galactocele | 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Cyst | 3 |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 1 2 2 3 2 2 2 2 1 1 2 2 2 2 2 2 1 2 1 2 2|
Skin, Site of Application, | |
Hyperkeratosis | 1 1 2 2 2 2 2 2 2 2 1 1 1 2 1 3 3 2 2 1 2 1|
Skin, Site of Application, | |
Hyperplasia | 1 2 2 2 2 2 2 1 1 2 1 2 2 3 2 2 1 3 2 2 2 2 2 2 2|
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 3 1 2 2 2 1 1|
Skin, Site of Application, | |
Parakeratosis | 2 2 1 2 2 2 4 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 2| 6| 6| 6| 7| 7| 5| 6| 6| 6| 5| 5| 5| 4| 7| 4| 6| 5|
DAY ON TEST | 0| 2| 5| 1| 5| 8| 0| 2| 1| 1| 0| 2| 2| 8| 3| 6| 0| 6| 9| 8| 8| 2| 9| 1| 2|
| 7| 8| 9| 1| 3| 0| 6| 4| 2| 5| 7| 8| 8| 0| 6| 8| 3| 7| 1| 0| 3| 8| 7| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Skin, Site of Application, Ulcer | 1 1 4 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + M + +|
Fibrous Osteodystrophy | 4 3 3 1 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Granulomatous | |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | |
Serosa, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2|
Casts | 3 |
Cyst | 2 3 3 2 2 3 2 2 |
Inflammation, Suppurative | 3 |
Mineralization | 3 2 |
Nephropathy | 4 2 3 4 4 4 4 3 1 3 3 2 4 4 1 2 4 1 2 4 4 1|
Pigmentation, Hemosiderin | 3 1 2|
Renal Tubule, Degeneration | 3 |
Renal Tubule, Hyperplasia, Oncocytic | 3 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Hemorrhage | |
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 7| 3| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 4| 5| |
DAY ON TEST | 5| 3| 9| 2| 1| 2| 7| 3| 2| 5| 2| 3| 3| 3| 5| 2| 2| 2| 2| 5| 0| 9| 2| 4| 4| |
| 1| 0| 9| 8| 1| 3| 4| 7| 1| 3| 8| 1| 8| 8| 4| 8| 7| 8| 8| 4| 3| 6| 8| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + A + + + +| 48 |
Mineralization | 2 | 3 1.7|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + + + A + + + A + + + + + + + + A + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A + + + + + + + + A + + + + + + + + A + + + +| 45 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 1.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + + + + + +| 45 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Basophilic Focus | X X X X X X X | 11 |
Clear Cell Focus | X X| 2 |
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X X X | 7 |
Inflammation, Chronic Active | 1 | 4 1.0|
Mixed Cell Focus | X X | 3 |
Vacuolization Cytoplasmic | 4 1 1 3 1 2| 12 1.8|
Bile Duct, Hyperplasia | 3 1 | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Inflammation, Chronic Active | 2 1 2 | 5 2.0|
Fat, Mineralization | | 2 2.0|
Fat, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 1 | 6 1.3|
Acinus, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 3 | 6 2.2|
Hyperkeratosis | 1 3 2 1 1 1 1 1 2| 26 1.7|
Hyperplasia, Basal Cell | | 1 1.0|
Inflammation, Chronic Active | 1 3 3 3 2 1 1 3| 23 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 7| 3| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 4| 5| |
DAY ON TEST | 5| 3| 9| 2| 1| 2| 7| 3| 2| 5| 2| 3| 3| 3| 5| 2| 2| 2| 2| 5| 0| 9| 2| 4| 4| |
| 1| 0| 9| 8| 1| 3| 4| 7| 1| 3| 8| 1| 8| 8| 4| 8| 7| 8| 8| 4| 3| 6| 8| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 3 | 3 1.7|
Mineralization | 1 | 1 1.0|
Perforation | 2 3 3 | 10 2.6|
Ulcer | 4 1 1 2 3| 14 2.3|
Epithelium, Hyperplasia | 1 3 1 1 1 1 1 1 2| 25 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 3.0|
Mineralization | 3 3 3 | 6 2.8|
Necrosis | | 1 1.0|
Perforation | | 1 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 3 2 | 5 3.4|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 2 1 1 2 2 2 2 2 1 1 2 2 1 2 2 1 2 2 1 1 | 38 1.8|
Mineralization | 3 2 | 4 3.3|
Thrombosis | 3 2 | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Angiectasis | 2 | 2 1.5|
Degeneration | | 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 2 2 2 2 1 1 1 2| 23 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.7|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 3 3 2 1 2 3 3 | 18 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 2 1.5|
Hyperplasia | | 2 1.5|
Mineralization | 1 | 2 1.5|
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 7| 3| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 4| 5| |
DAY ON TEST | 5| 3| 9| 2| 1| 2| 7| 3| 2| 5| 2| 3| 3| 3| 5| 2| 2| 2| 2| 5| 0| 9| 2| 4| 4| |
| 1| 0| 9| 8| 1| 3| 4| 7| 1| 3| 8| 1| 8| 8| 4| 8| 7| 8| 8| 4| 3| 6| 8| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ultimobranchial Cyst | | 1 1.0|
Follicle, Cyst | 2 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 2 3.5|
Inflammation, Chronic Active | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1| 35 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 3 4 1 | 10 2.5|
Inflammation, Suppurative | 3 3 | 3 2.7|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 2 2 3 3 2 2 3 3 3 | 14 2.4|
Mineralization | 4 2 2 1| 6 1.8|
Interstitial Cell, Hyperplasia | 1 1 1 3 1 2 1 2 1 1 1 3 | 23 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | 3 3 | 5 2.6|
Hemorrhage | 4 | 1 4.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | | 1 3.0|
Fibrosis | 1 2 4 | 6 2.0|
Hematopoietic Cell Proliferation | 4 | 6 2.3|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M M + + + + + + + + + + + + M + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 7| 3| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 4| 5| |
DAY ON TEST | 5| 3| 9| 2| 1| 2| 7| 3| 2| 5| 2| 3| 3| 3| 5| 2| 2| 2| 2| 5| 0| 9| 2| 4| 4| |
| 1| 0| 9| 8| 1| 3| 4| 7| 1| 3| 8| 1| 8| 8| 4| 8| 7| 8| 8| 4| 3| 6| 8| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 2 3 3 2 3 2 2 2 2 2| 16 2.3|
Galactocele | 4 4 4 2 3 3| 8 3.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Cyst | | 1 3.0|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 2 2 2 3 1 3 2 2 3 2 2 2 3 2 2 1 2 3 2 2 2 3 2| 45 2.0|
Skin, Site of Application, | | |
Hyperkeratosis | 1 2 2 1 3 2 1 2 3 2 1 1 1 2 2 1 2 1 1 1 2 2| 44 1.7|
Skin, Site of Application, | | |
Hyperplasia | 3 3 2 1 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2| 49 2.0|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 2 1 2 1 1 2 1 1 2 1 1 2 1 1 1 2 2 1 2 1 2 2| 48 1.4|
Skin, Site of Application, | | |
Parakeratosis | 3 3 1| 10 2.2|
Skin, Site of Application, Ulcer | 2 3 1 | 7 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 2 3 2 2 3 | 11 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Granulomatous | 3 | 1 3.0|
Mineralization | 2 1 | 3 1.7|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Serosa, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 7| 3| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 4| 5| |
DAY ON TEST | 5| 3| 9| 2| 1| 2| 7| 3| 2| 5| 2| 3| 3| 3| 5| 2| 2| 2| 2| 5| 0| 9| 2| 4| 4| |
| 1| 0| 9| 8| 1| 3| 4| 7| 1| 3| 8| 1| 8| 8| 4| 8| 7| 8| 8| 4| 3| 6| 8| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 2.0|
Casts | | 1 3.0|
Cyst | 2 2 2 3 | 12 2.3|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 2 1 2 | 5 2.0|
Nephropathy | 4 4 2 4 3 1 4 2 4 4 4 3 4 3 3 1 1 3 4 3| 42 3.0|
Pigmentation, Hemosiderin | 1 1 | 5 1.6|
Renal Tubule, Degeneration | | 1 3.0|
Renal Tubule, Hyperplasia, Oncocytic | | 1 3.0|
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X | 1 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 7| 4| 7| 4| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 1| 4| 8| 7| 7| 2| 9| 2| 8| 2| 2| 9| 2| 2| 4| 3| 2| 2| 2| 2| 0| 2| 3| 3| 7|
| 3| 7| 0| 6| 6| 3| 7| 8| 2| 8| 8| 1| 8| 8| 9| 2| 7| 8| 9| 8| 3| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Mineralization | 2|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Mineralization | 3|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + A A + A + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X |
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic Active | 1 1 |
Mixed Cell Focus | X X |
Necrosis | |
Vacuolization Cytoplasmic | 2 1 3 1 1 1 |
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Hyperkeratosis | 2 1 2 2 3 |
Hyperplasia, Basal Cell | 1 |
Inflammation, Chronic Active | 1 2 2 1 2 |
Inflammation, Suppurative | |
Mineralization | 1 4|
Necrosis | 2 |
Perforation | |
Ulcer | 3 2 |
Epithelium, Hyperplasia | 1 2 2 3 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 3 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 7| 4| 7| 4| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 1| 4| 8| 7| 7| 2| 9| 2| 8| 2| 2| 9| 2| 2| 4| 3| 2| 2| 2| 2| 0| 2| 3| 3| 7|
| 3| 7| 0| 6| 6| 3| 7| 8| 2| 8| 8| 1| 8| 8| 9| 2| 7| 8| 9| 8| 3| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 2 2 4|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 2 2 1 2 1 2 2 2 2 2 1 1 2 2 |
Mineralization | 2 2 2 2 4|
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hemorrhage | 3 |
Hyperplasia | |
Vacuolization Cytoplasmic | 1 2 2 1 2 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 1 3 2 2 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | 4 2 |
Hyperplasia | |
Mineralization | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation, Chronic Active | 3 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 4|
Mineralization | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation, Chronic Active | 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 7| 4| 7| 4| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 1| 4| 8| 7| 7| 2| 9| 2| 8| 2| 2| 9| 2| 2| 4| 3| 2| 2| 2| 2| 0| 2| 3| 3| 7|
| 3| 7| 0| 6| 6| 3| 7| 8| 2| 8| 8| 1| 8| 8| 9| 2| 7| 8| 9| 8| 3| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Degeneration | 2 2 2 2 4 3 2 |
Mineralization | 2 2 |
Interstitial Cell, Hyperplasia | 2 1 1 2 2 2 3 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + M + + M M|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 |
Galactocele | 2 2 4 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 1 2 3 1 2 2 3 3 4 1 2 2 1 2 1 1 1 2 1 2 2 1|
Skin, Site of Application, Fibrosis | 4 |
Skin, Site of Application, | |
Hyperkeratosis | 1 2 2 2 2 3 2 2 1 1 2 1 2 1 1 1 1 1 2 2 1|
Skin, Site of Application, | |
Hyperplasia | 1 2 3 2 1 2 2 2 4 3 1 2 2 1 3 3 1 2 2 2 1 2 2 3|
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1 1 2 1 1|
Skin, Site of Application, | |
Mineralization | 3 |
Skin, Site of Application, | |
Parakeratosis | 2 2 2 2 1 |
Skin, Site of Application, Ulcer | 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 3 3|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 7| 4| 7| 4| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 1| 4| 8| 7| 7| 2| 9| 2| 8| 2| 2| 9| 2| 2| 4| 3| 2| 2| 2| 2| 0| 2| 3| 3| 7|
| 3| 7| 0| 6| 6| 3| 7| 8| 2| 8| 8| 1| 8| 8| 9| 2| 7| 8| 9| 8| 3| 8| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Inflammation, Chronic Active | |
Mineralization | 3|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Mineralization | 1 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Mineralization | 2 1 3 1 3|
Nephropathy | 4 2 4 2 2 3 4 3 1 3 1 1 4 2 3 3 1 1 3 4|
Pigmentation, Hemosiderin | 2 1 1 2 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Mineralization | 2|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 6| 6| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 2| 3| 5| 2| 6| 1| 3| 1| 0| 7| 4| 3| 2| 2| 2| 2| 2| 8| 3| 0| 3| 9| 1| 7| 2| |
| 8| 8| 4| 8| 1| 8| 6| 0| 3| 6| 4| 5| 6| 8| 8| 8| 8| 0| 1| 2| 8| 6| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 3 | 2 2.5|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Mineralization | | 1 3.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + + + + + A A A + + + + + + + A + + + + +| 40 |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 2 2.5|
Ulcer | 2 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A + + + + + + A A + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + A + + + + + + A A + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X | 7 |
Clear Cell Focus | | 1 |
Hepatodiaphragmatic Nodule | X X| 5 |
Inflammation, Chronic Active | | 2 1.0|
Mixed Cell Focus | X X X | 5 |
Necrosis | 2 2 | 2 2.0|
Vacuolization Cytoplasmic | 1 1 2 1 2 2 1 1 2| 15 1.5|
Bile Duct, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Inflammation, Chronic Active | 2 | 2 2.0|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 1 | 3 1.7|
Hyperkeratosis | 2 2 2 3 1 1| 11 1.9|
Hyperplasia, Basal Cell | 1 | 2 1.0|
Inflammation, Chronic Active | 2 2 3 3 2 3| 11 2.1|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | 3 | 3 2.7|
Necrosis | 2 | 2 2.0|
Perforation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 6| 6| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 2| 3| 5| 2| 6| 1| 3| 1| 0| 7| 4| 3| 2| 2| 2| 2| 2| 8| 3| 0| 3| 9| 1| 7| 2| |
| 8| 8| 4| 8| 1| 8| 6| 0| 3| 6| 4| 5| 6| 8| 8| 8| 8| 0| 1| 2| 8| 6| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 2 2 2 3 4| 7 2.6|
Epithelium, Hyperplasia | 2 2 2 3 1 1 2| 13 1.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 3 3 | 8 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 1 2 2 2 1 2 3 2 1 2 2 2 1| 33 1.8|
Mineralization | 3 2 | 7 2.4|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 1.0|
Hemorrhage | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 2 2 2 2 1| 13 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Hyperplasia | 2 2 | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 1 2 3 | 12 2.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 2 3.0|
Hyperplasia | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 1 2.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 6| 6| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 2| 3| 5| 2| 6| 1| 3| 1| 0| 7| 4| 3| 2| 2| 2| 2| 2| 8| 3| 0| 3| 9| 1| 7| 2| |
| 8| 8| 4| 8| 1| 8| 6| 0| 3| 6| 4| 5| 6| 8| 8| 8| 8| 0| 1| 2| 8| 6| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 1 4.0|
Inflammation, Chronic Active | 1 2 2 1 2 1 1 2 1 1 1 1 1 1 1 1 4 1| 38 1.3|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Inflammation, Chronic Active | 3 2 4 2 3 | 7 2.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Degeneration | 3 3 3 2 | 11 2.5|
Mineralization | 1 2 2 | 5 1.8|
Interstitial Cell, Hyperplasia | 1 3 3 1 1 1 4 2 1 2| 20 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 | 5 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Fibrosis | 3 2 3 | 5 2.2|
Hematopoietic Cell Proliferation | 3 3 | 3 2.7|
Necrosis | 3 | 1 3.0|
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + M + + + + +| 44 |
Atrophy | 2 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Dilatation | 2 2 2 2 2 2 2 2 2 2| 12 1.8|
Galactocele | 3 4 3 3| 10 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 1 2 1 1 2 2 2 1 2 1 2 2 1 2 2 2 2 3 3 1 3 1 2| 45 1.8|
Skin, Site of Application, Fibrosis | | 1 4.0|
Skin, Site of Application, | | |
Hyperkeratosis | 2 2 2 2 2 2 1 1 3 1 1 1 1 2 2 2 1 2 1 | 40 1.6|
Skin, Site of Application, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 6| 6| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 2| 3| 5| 2| 6| 1| 3| 1| 0| 7| 4| 3| 2| 2| 2| 2| 2| 8| 3| 0| 3| 9| 1| 7| 2| |
| 8| 8| 4| 8| 1| 8| 6| 0| 3| 6| 4| 5| 6| 8| 8| 8| 8| 0| 1| 2| 8| 6| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 2 2 2 2 2 2 1 3 1 3 2 2 2 3 2 1 3 1 3 2 3 2 2| 47 2.1|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 2 1 1 2 2 2 1 1 2 2 2 1 1 1 3 1 2 1 2 1 1| 41 1.4|
Skin, Site of Application, | | |
Mineralization | | 1 3.0|
Skin, Site of Application, | | |
Parakeratosis | 2 1 3 2 4 1 | 11 2.0|
Skin, Site of Application, Ulcer | 1 2 3 | 6 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 2 2.0|
Inflammation, Chronic Active | 1 1 1 1 | 4 1.0|
Mineralization | 3 2 | 3 2.7|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 3 | 2 2.5|
Inflammation, Suppurative | 2 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Mineralization | | 1 1.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 4 2.3|
Mineralization | 3 2 | 7 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 91014-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/25/97
Route: SKIN APPLICATION Time: 07:43:45
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 6| 6| 7| 7| 6| 6| 5| 5| 7| 7| 7| 7| 5| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 2| 3| 5| 2| 6| 1| 3| 1| 0| 7| 4| 3| 2| 2| 2| 2| 2| 8| 3| 0| 3| 9| 1| 7| 2| |
| 8| 8| 4| 8| 1| 8| 6| 0| 3| 6| 4| 5| 6| 8| 8| 8| 8| 0| 1| 2| 8| 6| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 1 1 3 4 1 2 4 1 3 1 4 4 4 2 1 1 1 4 3| 40 2.4|
Pigmentation, Hemosiderin | 2 2 1 1 | 8 1.5|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Regeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
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---------- END OF REPORT ----------
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