Statistical Analysis Of Survival Data
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus OLEIC ACID DIETHANOLAMINE CONDENSATE DATE: 09/23/97
EXPERIMENT: 91014 TEST: 04 TIME: 09:48:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-15314 ROUTE: SKIN APPLICATION NTP C#: C91014
PATHOLOGIST: SELLS, D. CAS: 93-83-4
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC
REASONS FOR REMOVAL: 25022 Accidently Killed
25023 Missing
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 MG/KG
INCLUDE 002 0 MG/KG
INCLUDE 003 15 MG/KG
INCLUDE 004 15 MG/KG
INCLUDE 005 30 MG/KG
INCLUDE 006 30 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus OLEIC ACID DIETHANOLAMINE CONDENSATE DATE: 09/23/97
EXPERIMENT: 91014 TEST: 04 TIME: 09:48:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-15314 ROUTE: SKIN APPLICATION NTP C#: C91014
PATHOLOGIST: SELLS, D. CAS: 93-83-4
OLEIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 1 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 452 456 485 561 667 691 695 699 |
| CENSORED DEATHS |
| 38 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 176 425 547 567 621 624 628 628 660 686 |
| 697 708 709 712 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 356 416 468 488 537 549 572 577 606 638 |
| 638 642 660 676 691 705 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OLEIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 93.9 93.9 91.8 91.8 83.7 |
| | |
| | |
|15 MG/KG | 100.0 98.0 98.0 98.0 96.0 96.0 96.0 92.0 82.0 70.0 |
| | |
| | |
|30 MG/KG | 100.0 100.0 100.0 98.0 96.0 94.0 90.0 84.0 74.0 68.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 15 MG/KG 30 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 83.7% 70.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.086 P=0.182 P=0.102 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 588.3 607.2 576.2 |
|NATURAL DEATHS (C) | (39.6) (37.0) (25.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 692.7 692.5 680.1 |
|(STANDARD ERROR) | (16.4) (13.4) (12.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OLEIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 150 435 471 562 562 578 603 615 621 654 |
| 660 675 682 683 719 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 15 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 240 445 501 584 585 604 616 624 639 641 |
| 646 659 659 662 677 682 682 704 704 711 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 1 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 386 478 524 527 552 604 605 637 659 669 |
| 673 692 721 723 |
| CENSORED DEATHS |
| 369 |
| |
==================================================================================
OLEIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 98.0 98.0 98.0 98.0 94.0 94.0 86.0 78.0 68.0 |
| | |
| | |
|15 MG/KG | 100.0 100.0 98.0 98.0 98.0 96.0 94.0 88.0 72.0 60.0 |
| | |
| | |
|30 MG/KG | 100.0 100.0 100.0 100.0 98.0 95.9 91.8 85.7 81.6 71.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 15 MG/KG 30 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 60.0% 71.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.780N P=0.561 P=0.847N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 586.9 613.3 603.6 |
|NATURAL DEATHS (C) | (35.5) (24.6) (26.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 684.2 683.3 687.4 |
|(STANDARD ERROR) | (14.6) (12.7) (12.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OLEIC ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
15 MG/KG = 2
30 MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 3 32 11
|
96 + 32 13 1 2
|
| 3 1 2 1
|
P 92 + 3 3 1 2 1
E |
R | 3 3 22 1 1
C |
E 88 + 3 3 11
N |
T | 33
|
S 84 + 3 3 2 2 1 1
U |
R | 3 3 2 2
V |
I 80 + 2 2
V |
A | 2 2
L |
76 + 3 3
|
| 3 3
|
72 + 3 3 22
|
| 3 3 2 2
|
68 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
OLEIC ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
15 MG/KG = 2
30 MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
|
| 1 2 3 12 3
| 12 13 2 3
95 +
| 1 2 33 1 2
|
| 3 3
P 90 + 3 1 12 2
E |
R | 1 12
C | 11 23
E 85 +
N | 11232 3
T | 1 1
| 33
S 80 + 221 133
U |
R | 2 1 1 3
V | 11
I 75 + 3 3
V | 33
A | 2 21 1
L | 3 3
70 + 22
|
| 1 1
| 2 2
65 +
|
| 22
|
60 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.