TDMS Study 92012-05 Pathology Tables
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:01:01
27 WEEK SSAC
Facility: Southern Research Institute
Chemical CAS #: 693-98-1
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%) 1 (10%)
Inflammation, Granulomatous 10 (100%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 1 (10%) 2 (20%) 1 (10%)
Pars Distalis, Mitotic Alteration 1 (10%) 2 (20%) 2 (20%) 2 (20%)
Pars Intermedia, Cyst 1 (10%) 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Follicle, Mineralization, Focal 1 (10%) 6 (60%) 10 (100%) 10 (100%)
Follicular Cell, Hyperplasia 5 (50%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 1 (10%) 1 (10%)
Periovarian Tissue, Cyst 1 (10%)
Uterus (10) (10) (10) (10)
Hydrometra 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (3) (4) (1) (3)
Mediastinal, Hemorrhage 1 (33%) 1 (25%) 2 (67%)
Pancreatic, Hemorrhage 2 (50%) 1 (33%)
Pancreatic, Hyperplasia, Lymphoid 2 (67%) 1 (25%) 1 (100%)
Spleen (10) (10) (10) (10)
Accessory Spleen 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Cyst Epithelial Inclusion 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (10) (10) (10) (10)
Retrobulbar, Inflammation, Focal 1 (10%)
Harderian Gland (10) (10) (10) (10)
Hyperplasia, Focal, Lymphoid 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0PPM 1000 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Inflammation, Focal, Granulomatous 1 (10%) 5 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Cyst 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 2 (20%) 1 (10%)
Hyperplasia, Focal, Mast Cell 1 (10%)
Infiltration Cellular, Focal,
Polymorphonuclear 1 (10%)
Inflammation, Granulomatous 9 (90%) 7 (70%) 10 (100%) 10 (100%)
Mesentery (1)
Fat, Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 2 (20%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 1 (10%) 2 (20%) 1 (10%)
Pars Distalis, Mitotic Alteration 1 (10%) 1 (10%)
Pars Distalis, Vacuolization Cytoplasmic,
Focal 1 (10%)
Pars Intermedia, Cyst 2 (20%)
Thyroid Gland (10) (10) (10) (10)
Follicle, Mineralization, Focal 1 (10%) 4 (40%) 9 (90%) 9 (90%)
Follicular Cell, Hyperplasia 7 (70%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1) (1)
Mediastinal, Hemorrhage 1 (100%) 1 (100%)
Pancreatic, Hemorrhage 1 (100%)
Lymph Node, Mesenteric (10) (10) (10) (10)
Hemorrhage 1 (10%)
Spleen (10) (10) (10) (10)
Accessory Spleen 2 (20%)
Thymus (10) (10) (10) (10)
Hemorrhage 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 92012-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0PPM 300 PPM 1000 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Harderian Gland (10) (10) (10) (10)
Inflammation, Focal, Granulomatous 1 (10%)
Necrosis, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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