TDMS Study 92012-05 Pathology Tables

NTP Experiment-Test: 92012-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03
Route: DOSED FEED                                                                                                 Time: 14:09:20
                                                          27 WEEK SSAC
       Facility:  Southern Research Institute
       Chemical CAS #:  693-98-1
       Lock Date:  10/16/01
       Cage Range:  All
       Reasons For Removal:    25017 Scheduled Sacrifice
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 92012-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03  
Route: DOSED FEED                                                                                                 Time: 14:09:20  
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         FISCHER 344 RATS FEMALE                   0PPM         1000 PPM     2500 PPM     5000 PPM                                  
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
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 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicular Cell, Adenoma                                                                2 (20%)                               
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
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                                                             Page   2                                                               
NTP Experiment-Test: 92012-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03  
Route: DOSED FEED                                                                                                 Time: 14:09:20  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0PPM         1000 PPM     2500 PPM     5000 PPM                                  
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   3                                                               
NTP Experiment-Test: 92012-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03  
Route: DOSED FEED                                                                                                 Time: 14:09:20  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0PPM         1000 PPM     2500 PPM     5000 PPM                                  
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)                                                 2                                       
     Total Primary Neoplasms                                                                2                                       
   Total Animals with Benign Neoplasms                                                      2                                       
     Total Benign Neoplasms                                                                 2                                       
   Total Animals with Malignant Neoplasms                                                                                           
     Total Malignant Neoplasms                                                                                                      
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   4                                                               
NTP Experiment-Test: 92012-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03  
Route: DOSED FEED                                                                                                 Time: 14:09:20  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0PPM         300 PPM      1000 PPM     3000 PPM                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 92012-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03  
Route: DOSED FEED                                                                                                 Time: 14:09:20  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0PPM         300 PPM      1000 PPM     3000 PPM                                  
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
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