TDMS Study 92012-05 Pathology Tables
NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 27 WEEK SSAC Facility: Southern Research Institute Chemical CAS #: 693-98-1 Lock Date: 10/16/01 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to days on test Page 1 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node | + + + | 3 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1000 PPM | 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1000 PPM | 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 4 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1000 PPM | 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1000 PPM | 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A | 2500 PPM | 6| 6| 6| 6| 7| 0| 0| 0| 0| 1| | L | | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A | 2500 PPM | 6| 6| 6| 6| 7| 0| 0| 0| 0| 1| | L | | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M M + + + + + + | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A | 2500 PPM | 6| 6| 6| 6| 7| 0| 0| 0| 0| 1| | L | | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A | 2500 PPM | 6| 6| 6| 6| 7| 0| 0| 0| 0| 1| | L | | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + + | 9 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicular Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + + | 9 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node | + + + | 3 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0PPM | 0| 0| 0| 3| 3| 3| 4| 5| 5| 5| | L | | 4| 5| 6| 7| 8| 9| 0| 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + M | 9 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0PPM | 0| 0| 0| 3| 3| 3| 4| 5| 5| 5| | L | | 4| 5| 6| 7| 8| 9| 0| 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + | 9 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0PPM | 0| 0| 0| 3| 3| 3| 4| 5| 5| 5| | L | | 4| 5| 6| 7| 8| 9| 0| 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0PPM | 0| 0| 0| 3| 3| 3| 4| 5| 5| 5| | L | | 4| 5| 6| 7| 8| 9| 0| 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 300 PPM | 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| | L | | 2| 4| 5| 6| 2| 3| 4| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 300 PPM | 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| | L | | 2| 4| 5| 6| 2| 3| 4| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M + M M M M | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 300 PPM | 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| | L | | 2| 4| 5| 6| 2| 3| 4| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + M M + M + + M M | 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 300 PPM | 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| | L | | 2| 4| 5| 6| 2| 3| 4| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1000 PPM | 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 6| 7| 8| 9| 0| 1| 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Mesentery | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1000 PPM | 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 6| 7| 8| 9| 0| 1| 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + | 9 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1000 PPM | 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 6| 7| 8| 9| 0| 1| 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1000 PPM | 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 6| 7| 8| 9| 0| 1| 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A | 3000 PPM | 8| 8| 8| 9| 9| 9| 2| 3| 3| 3| | L | | 7| 8| 9| 3| 4| 5| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A | 3000 PPM | 8| 8| 8| 9| 9| 9| 2| 3| 3| 3| | L | | 7| 8| 9| 3| 4| 5| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M + M M M M M | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A | 3000 PPM | 8| 8| 8| 9| 9| 9| 2| 3| 3| 3| | L | | 7| 8| 9| 3| 4| 5| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + I I + M M M | 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 92012-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:17:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A | 3000 PPM | 8| 8| 8| 9| 9| 9| 2| 3| 3| 3| | L | | 7| 8| 9| 3| 4| 5| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------