TDMS Study 92012-05 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst 2-METHYLIMIDAZOLE DATE: 02/24/03
EXPERIMENT: 92012 TEST: 05 TIME: 13:42:55
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C92012B
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE 2-METHYLIMIDAZOLE DATE: 02/24/03
EXPERIMENT: 92012 TEST: 05 TIME: 13:56:15
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: 92012B
CONT: N01-ES-85420 CAS: 693-98-1
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE
==================================================================================================================================
0PPM 300 PPM 1000 PPM 3000 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 18.7 212.8 18.5 207.2 0.99 27 18.1 209.0 0.97 87 15.8 193.3 0.84 246
8 18.0 284.1 16.9 279.9 0.94 18 18.0 280.4 1.00 64 16.2 256.9 0.90 189
12 16.6 320.1 16.8 314.9 1.01 16 16.1 314.8 0.97 51 15.2 288.6 0.92 158
16 16.9 347.8 16.9 343.6 1.00 15 17.0 341.3 1.01 50 15.6 318.1 0.92 147
20 16.6 366.6 16.5 359.8 0.99 14 16.6 359.6 1.00 46 15.1 334.0 0.91 136
24 16.6 378.4 16.0 371.0 0.96 13 15.8 369.4 0.95 43 15.5 347.0 0.93 134
28 15.5 385.8 15.9 382.0 1.03 12 15.7 376.6 1.01 42 14.1 361.5 0.91 117
32 16.5 401.4 16.6 395.1 1.01 13 16.3 391.9 0.99 42 16.7 376.7 1.01 133
36 16.6 414.6 16.7 405.3 1.01 12 15.8 402.6 0.95 39 16.3 387.5 0.98 126
40 16.8 422.1 16.9 418.7 1.01 12 16.8 414.3 1.00 41 15.7 399.5 0.93 118
44 16.2 428.6 17.0 423.4 1.05 12 16.9 420.7 1.04 40 16.3 405.7 1.01 121
48 16.3 436.0 15.7 428.2 0.96 11 15.9 425.9 0.98 37 15.4 410.5 0.94 112
52 15.7 437.4 16.2 434.9 1.03 11 16.1 431.6 1.03 37 15.3 414.2 0.97 111
56 16.6 444.0 16.8 437.1 1.01 11 16.2 432.3 0.98 37 16.1 416.7 0.97 116
60 16.9 445.6 17.3 438.4 1.02 12 16.8 435.2 0.99 39 16.4 419.7 0.97 117
64 16.3 444.0 16.2 439.8 0.99 11 16.2 433.0 0.99 37 15.2 413.4 0.93 110
72 15.8 446.9 16.4 439.2 1.04 11 15.6 436.5 0.99 36 14.9 422.1 0.94 106
76 15.9 443.1 15.7 442.7 0.99 11 15.3 434.8 0.96 35 14.6 419.9 0.92 104
80 15.7 439.5 15.9 432.5 1.01 11 15.6 429.7 0.99 36 15.3 409.8 0.97 112
84 15.0 435.9 15.1 431.1 1.01 11 15.2 425.2 1.01 36 15.1 406.5 1.01 111
88 14.3 431.4 15.3 428.8 1.07 11 15.2 421.5 1.06 36 14.8 400.1 1.03 111
92 13.4 421.5 14.1 425.1 1.05 10 14.2 415.8 1.06 34 14.1 400.0 1.05 105
96 14.7 421.2 14.8 419.6 1.01 11 15.0 412.4 1.02 36 14.8 397.3 1.01 112
100 14.9 419.3 16.3 421.1 1.09 12 14.2 407.8 0.95 35 14.1 390.3 0.95 108
104 15.1 415.4 15.6 414.0 1.03 11 15.2 406.7 1.01 37 13.1 375.2 0.87 104
1 TO 13 WEEKS
----------------
MEAN 17.8 272.3 17.4 267.3 0.98 20 17.4 268.1 0.98 67 15.7 246.3 0.89 197
SD(D) 1.1 0.9 0.04 6 1.1 0.02 18 0.5 0.04 45
CV(E) 6.2 5.4 3.8 28.0 6.3 1.8 26.7 3.4 4.2 22.6
14 TO 52 WEEKS
----------------
MEAN 16.4 401.9 16.4 396.2 1.00 13 16.3 393.4 1.00 42 15.6 375.5 0.95 125
SD(D) 0.5 0.5 0.03 1 0.5 0.03 4 0.7 0.04 12
CV(E) 2.8 2.8 2.7 8.8 3.0 3.0 9.2 4.6 4.0 9.3
> 52 WEEKS
----------------
MEAN 15.4 434.0 15.8 430.8 1.03 11 15.4 424.2 1.00 36 14.9 405.9 0.97 110
SD(D) 1.0 0.9 0.03 1 0.8 0.03 1 0.9 0.05 4
CV(E) 6.5 5.6 3.1 4.9 4.9 3.4 3.4 6.0 5.4 3.9
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE
==================================================================================================================================
0PPM 1000 PPM 2500 PPM 5000 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 13.2 148.0 13.2 148.1 1.00 89 11.5 141.7 0.87 202 10.1 133.3 0.77 381
8 11.4 173.0 11.3 175.4 0.99 65 11.1 167.6 0.97 165 9.6 154.0 0.84 310
12 10.8 183.7 11.1 183.5 1.03 61 10.4 176.9 0.96 147 9.1 160.2 0.84 286
16 10.3 192.9 10.5 191.1 1.02 55 9.8 183.6 0.95 134 8.2 166.4 0.80 245
20 10.2 197.8 10.0 197.1 0.98 51 9.5 190.9 0.93 124 8.3 170.7 0.81 242
24 10.1 204.4 10.4 203.4 1.03 51 9.3 196.6 0.92 119 8.2 177.7 0.81 229
28 9.8 210.2 10.2 208.4 1.04 49 9.8 202.4 1.00 121 8.4 185.1 0.86 226
32 10.5 217.0 10.6 214.8 1.01 49 9.9 207.7 0.94 119 9.2 192.7 0.88 237
36 10.3 224.1 10.7 220.2 1.04 49 10.1 213.7 0.98 118 9.1 196.5 0.88 232
40 10.6 230.7 10.6 228.1 1.00 47 10.1 220.7 0.95 115 9.0 203.7 0.85 220
44 11.1 238.1 11.0 235.2 0.99 47 10.7 225.3 0.96 119 9.2 205.9 0.83 223
48 10.7 241.7 11.0 240.1 1.03 46 10.5 229.6 0.98 114 9.3 211.3 0.87 221
52 10.8 245.9 11.9 247.2 1.10 48 10.9 234.7 1.01 116 9.1 211.1 0.84 215
56 11.9 256.6 11.3 256.9 0.95 44 10.8 239.6 0.91 112 9.6 216.9 0.81 221
60 11.9 268.4 12.2 266.0 1.03 46 11.6 249.3 0.97 117 9.8 219.9 0.82 224
64 11.5 274.5 11.6 273.4 1.01 42 11.2 253.8 0.97 111 9.5 222.8 0.83 214
72 12.3 290.8 11.8 287.9 0.96 41 10.8 264.1 0.88 102 8.6 228.3 0.70 189
76 11.8 296.9 11.6 291.2 0.98 40 11.6 269.2 0.98 108 9.5 229.6 0.81 207
80 12.1 297.2 12.0 293.4 0.99 41 11.8 272.7 0.98 109 9.8 229.8 0.81 214
84 11.2 299.6 11.3 295.3 1.01 38 11.3 274.9 1.01 102 10.0 232.4 0.89 214
88 11.1 304.2 11.8 299.1 1.06 39 11.4 278.5 1.03 102 9.3 234.2 0.84 199
92 11.0 312.3 10.8 304.4 0.98 35 10.4 282.9 0.95 92 9.0 232.1 0.82 194
96 12.3 313.9 12.7 305.5 1.03 41 12.0 285.0 0.98 105 10.0 232.7 0.81 215
100 12.1 318.5 12.0 308.4 0.99 39 11.3 284.6 0.93 99 9.7 230.7 0.80 210
104 12.0 320.6 12.0 308.5 1.00 39 12.0 283.1 1.00 106 10.0 227.5 0.83 219
1 TO 13 WEEKS
----------------
MEAN 11.8 168.2 11.9 169.0 1.01 71 11.0 162.1 0.94 171 9.6 149.1 0.82 325
SD(D) 1.2 1.2 0.02 15 0.5 0.06 28 0.5 0.04 49
CV(E) 10.6 9.7 1.9 21.7 5.0 6.0 16.5 5.2 5.5 15.1
14 TO 52 WEEKS
----------------
MEAN 10.4 220.3 10.7 218.6 1.02 49 10.1 210.5 0.96 120 8.8 192.1 0.84 229
SD(D) 0.4 0.5 0.03 3 0.5 0.03 6 0.5 0.03 10
CV(E) 3.9 4.9 3.3 5.5 5.1 3.0 4.8 5.4 3.5 4.4
> 52 WEEKS
----------------
MEAN 11.8 296.1 11.8 290.8 1.00 41 11.4 269.8 0.97 105 9.6 228.1 0.81 210
SD(D) 0.4 0.5 0.03 3 0.5 0.04 7 0.4 0.04 11
CV(E) 3.8 4.1 3.1 6.7 4.4 4.4 6.2 4.4 5.4 5.2
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE
=========================================================================================================
0PPM 300 PPM 1000 PPM 3000 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
B 114.4 60 112.7 60 113.5 60 113.2 60
1 114.4 60 112.7 60 113.5 60 113.2 60
4 18.7 9780 212.8 60 18.5 9760 207.2 60 18.1 9738 209.0 60 15.8 9980 193.3 60
8 18.0 9783 284.1 60 16.9 9745 279.9 60 18.0 9635 280.4 60 16.2 9610 256.9 60
12 16.6 10165 320.1 60 16.8 10010 314.9 60 16.1 10035 314.8 60 15.2 9975 288.6 60
16 16.9 9939 347.8 60 16.9 9917 343.6 60 17.0 9900 341.3 60 15.6 9740 318.1 60
20 16.6 9991 366.6 60 16.5 9915 359.8 60 16.6 9975 359.6 60 15.1 9878 334.0 60
24 16.6 9895 378.4 60 16.0 9895 371.0 60 15.8 9882 369.4 60 15.5 9740 347.0 60
28 15.5 8388 385.8 50 15.9 8383 382.0 50 15.7 8374 376.6 50 14.1 8267 361.5 50
32 16.5 8221 401.4 50 16.6 8100 395.1 50 16.3 8118 391.9 50 16.7 8072 376.7 50
36 16.6 8114 414.6 50 16.7 8243 405.3 50 15.8 8131 402.6 50 16.3 8033 387.5 50
40 16.8 8290 422.1 50 16.9 8135 418.7 50 16.8 8165 414.3 50 15.7 8077 399.5 49
44 16.2 8258 428.6 50 17.0 8225 423.4 50 16.9 8187 420.7 50 16.3 8181 405.7 49
48 16.3 7938 436.0 49 15.7 8095 428.2 50 15.9 8252 425.9 50 15.4 8056 410.5 49
52 15.7 8150 437.4 49 16.2 8294 434.9 50 16.1 8291 431.6 50 15.3 8095 414.2 49
56 16.6 7911 444.0 49 16.8 8100 437.1 50 16.2 8215 432.3 50 16.1 7947 416.7 49
60 16.9 7917 445.6 49 17.3 8064 438.4 50 16.8 7891 435.2 49 16.4 7706 419.7 48
64 16.3 7926 444.0 49 16.2 8065 439.8 50 16.2 7262 433.0 48 15.2 7728 413.4 48
68 442.5 49 437.5 50 429.4 48 417.1 48
72 15.8 8558 446.9 49 16.4 8734 439.2 50 15.6 8208 436.5 47 14.9 8191 422.1 47
76 15.9 8217 443.1 49 15.7 7985 442.7 48 15.3 7819 434.8 47 14.6 7818 419.9 47
80 15.7 6641 439.5 49 15.9 7683 432.5 47 15.6 7338 429.7 45 15.3 7773 409.8 47
84 15.0 7980 435.9 48 15.1 7644 431.1 46 15.2 7256 425.2 44 15.1 7309 406.5 45
88 14.3 7679 431.4 47 15.3 7171 428.8 44 15.2 7151 421.5 44 14.8 6642 400.1 42
92 13.4 7499 421.5 46 14.1 7599 425.1 44 14.2 7014 415.8 44 14.1 7058 400.0 41
96 14.7 7222 421.2 44 14.8 6944 419.6 43 15.0 6792 412.4 42 14.8 6662 397.3 41
100 14.9 6553 419.3 39 16.3 6702 421.1 40 14.2 6401 407.8 39 14.1 6078 390.3 35
104 15.1 5965 415.4 36 15.6 6568 414.0 40 15.2 5870 406.7 36 13.1 5690 375.2 35
MEAN BODY WGT FOR WEEKS
1 TO 13 232.8 228.7 229.5 213.0
14 TO 52 401.9 396.2 393.4 375.5
> 52 434.6 431.3 424.6 406.8
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE
=========================================================================================================
0PPM 1000 PPM 2500 PPM 5000 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
B 98.5 60 99.2 60 98.2 60 97.7 60
1 98.5 60 99.2 60 98.2 60 97.7 60
4 13.2 9838 148.0 60 13.2 9768 148.1 60 11.5 9726 141.7 60 10.1 9970 133.3 60
8 11.4 9582 173.0 60 11.3 9653 175.4 60 11.1 9624 167.6 60 9.6 9564 154.0 60
12 10.8 10128 183.7 60 11.1 10019 183.5 60 10.4 9990 176.9 60 9.1 10032 160.2 60
16 10.3 9904 192.9 60 10.5 9884 191.1 60 9.8 9900 183.6 60 8.2 9858 166.4 60
20 10.2 10026 197.8 60 10.0 9989 197.1 60 9.5 9924 190.9 60 8.3 9820 170.7 60
24 10.1 9888 204.4 60 10.4 9882 203.4 60 9.3 9864 196.6 60 8.2 9860 177.7 60
28 9.8 8390 210.2 50 10.2 8360 208.4 50 9.8 8310 202.4 50 8.4 8260 185.1 50
32 10.5 8220 217.0 50 10.6 8135 214.8 50 9.9 8106 207.7 50 9.2 8065 192.7 50
36 10.3 8110 224.1 50 10.7 8154 220.2 50 10.1 7932 213.7 49 9.1 8076 196.5 50
40 10.6 8263 230.7 50 10.6 8230 228.1 50 10.1 8114 220.7 49 9.0 8260 203.7 50
44 11.1 8292 238.1 50 11.0 8175 235.2 50 10.7 8052 225.3 49 9.2 8256 205.9 50
48 10.7 7940 241.7 49 11.0 8250 240.1 50 10.5 7997 229.6 49 9.3 8119 211.3 50
52 10.8 8145 245.9 49 11.9 8265 247.2 50 10.9 7909 234.7 48 9.1 8247 211.1 50
56 11.9 7897 256.6 49 11.3 8237 256.9 50 10.8 7009 239.6 48 9.6 8117 216.9 50
60 11.9 7906 268.4 49 12.2 8055 266.0 50 11.6 7735 249.3 48 9.8 8021 219.9 50
64 11.5 7934 274.5 49 11.6 7901 273.4 49 11.2 7737 253.8 48 9.5 7878 222.8 49
68 281.6 49 281.1 49 259.5 48 226.0 49
72 12.3 8565 290.8 49 11.8 8215 287.9 47 10.8 8228 264.1 47 8.6 8565 228.3 49
76 11.8 8144 296.9 49 11.6 7812 291.2 47 11.6 7700 269.2 46 9.5 8144 229.6 49
80 12.1 5647 297.2 49 12.0 7344 293.4 45 11.8 6963 272.7 42 9.8 8110 229.8 49
84 11.2 8049 299.6 48 11.3 7410 295.3 45 11.3 6728 274.9 41 10.0 7944 232.4 49
88 11.1 7329 304.2 45 11.8 7149 299.1 44 11.4 6330 278.5 39 9.3 7938 234.2 49
92 11.0 7624 312.3 44 10.8 7348 304.4 42 10.4 6433 282.9 37 9.0 8310 232.1 48
96 12.3 6935 313.9 42 12.7 6863 305.5 42 12.0 5569 285.0 33 10.0 7755 232.7 47
100 12.1 6842 318.5 41 12.0 6594 308.4 40 11.3 5259 284.6 32 9.7 7437 230.7 45
104 12.0 6592 320.6 40 12.0 6364 308.5 39 12.0 4566 283.1 28 10.0 6917 227.5 42
MEAN BODY WGT FOR WEEKS
1 TO 13 150.8 151.6 146.1 136.3
14 TO 52 220.3 218.6 210.5 192.1
> 52 295.0 290.1 269.0 227.9
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.