TDMS Study 92012-05 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Southern Research Inst 2-METHYLIMIDAZOLE DATE: 02/24/03
EXPERIMENT: 92012 TEST: 05 TIME: 13:43:01
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C92012B
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: SOUTHERN RESEARCH INSTITUTE 2-METHYLIMIDAZOLE DATE: 02/24/03
EXPERIMENT: 92012 TEST: 05 TIME: 13:54:02
SPECIES: RATS, FISCHER 344
TEST TYPE: TWO YEAR ROUTE: DOSED FEED NTP: 92012B
CONT: N01-ES-85420 CAS: 693-98-1
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
TWO YEAR DOSED FEED STUDY OF 2-METHYLIMIDAZOLE
==========================================================================================================
WEEK 0PPM 300 PPM 1000 PPM 3000 PPM
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 114.4 60 112.7 98.5 60 113.5 99.2 60 113.2 99.0 60
1 114.4 60 112.7 98.5 60 113.5 99.2 60 113.2 99.0 60
4 212.8 60 207.2 97.4 60 209.0 98.2 60 193.3 90.8 60
8 284.1 60 279.9 98.5 60 280.4 98.7 60 256.9 90.4 60
12 320.1 60 314.9 98.4 60 314.8 98.3 60 288.6 90.2 60
16 347.8 60 343.6 98.8 60 341.3 98.1 60 318.1 91.5 60
20 366.6 60 359.8 98.1 60 359.6 98.1 60 334.0 91.1 60
24 378.4 60 371.0 98.0 60 369.4 97.6 60 347.0 91.7 60
28 385.8 50 (I) 382.0 99.0 50 (I) 376.6 97.6 50 (I) 361.5 93.7 50 (I)
32 401.4 50 395.1 98.4 50 391.9 97.6 50 376.7 93.8 50
36 414.6 50 405.3 97.8 50 402.6 97.1 50 387.5 93.5 50
40 422.1 50 418.7 99.2 50 414.3 98.2 50 399.5 94.6 49
44 428.6 50 423.4 98.8 50 420.7 98.2 50 405.7 94.7 49
48 436.0 49 428.2 98.2 50 425.9 97.7 50 410.5 94.2 49
52 437.4 49 434.9 99.4 50 431.6 98.7 50 414.2 94.7 49
56 444.0 49 437.1 98.4 50 432.3 97.4 50 416.7 93.9 49
60 445.6 49 438.4 98.4 50 435.2 97.7 49 419.7 94.2 48
64 444.0 49 439.8 99.1 50 433.0 97.5 48 413.4 93.1 48
68 442.5 49 437.5 98.9 50 429.4 97.0 48 417.1 94.3 48
72 446.9 49 439.2 98.3 50 436.5 97.7 47 422.1 94.5 47
76 443.1 49 442.7 99.9 48 434.8 98.1 47 419.9 94.8 47
80 439.5 49 432.5 98.4 47 429.7 97.8 45 409.8 93.2 47
84 435.9 48 431.1 98.9 46 425.2 97.5 44 406.5 93.3 45
88 431.4 47 428.8 99.4 44 421.5 97.7 44 400.1 92.7 42
92 421.5 46 425.1 100.9 44 415.8 98.6 44 400.0 94.9 41
96 421.2 44 419.6 99.6 43 412.4 97.9 42 397.3 94.3 41
100 419.3 39 421.1 100.4 40 407.8 97.3 39 390.3 93.1 35*
104 415.4 36 414.0 99.7 40 406.7 97.9 36 375.2 90.3 35
TERM. SAC. 35 40 36 35
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR DOSED FEED STUDY OF 2-METHYLIMIDAZOLE
==========================================================================================================
WEEK 0PPM 1000 PPM 2500 PPM 5000 PPM
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 98.5 60 99.2 100.7 60 98.2 99.7 60 97.7 99.2 60
1 98.5 60 99.2 100.7 60 98.2 99.7 60 97.7 99.2 60
4 148.0 60 148.1 100.1 60 141.7 95.7 60 133.3 90.1 60
8 173.0 60 175.4 101.4 60 167.6 96.9 60 154.0 89.0 60
12 183.7 60 183.5 99.9 60 176.9 96.3 60 160.2 87.2 60
16 192.9 60 191.1 99.1 60 183.6 95.2 60 166.4 86.3 60
20 197.8 60 197.1 99.6 60 190.9 96.5 60 170.7 86.3 60
24 204.4 60 203.4 99.5 60 196.6 96.2 60 177.7 86.9 60
28 210.2 50 (I) 208.4 99.1 50 (I) 202.4 96.3 50 (I) 185.1 88.1 50 (I)
32 217.0 50 214.8 99.0 50 207.7 95.7 50 192.7 88.8 50
36 224.1 50 220.2 98.3 50 213.7 95.4 49 196.5 87.7 50
40 230.7 50 228.1 98.9 50 220.7 95.7 49 203.7 88.3 50
44 238.1 50 235.2 98.8 50 225.3 94.6 49 205.9 86.5 50
48 241.7 49 240.1 99.3 50 229.6 95.0 49 211.3 87.4 50
52 245.9 49 247.2 100.5 50 234.7 95.4 48 211.1 85.8 50
56 256.6 49 256.9 100.1 50 239.6 93.4 48 216.9 84.5 50
60 268.4 49 266.0 99.1 50 249.3 92.9 48 219.9 81.9 50
64 274.5 49 273.4 99.6 49 253.8 92.5 48 222.8 81.2 49
68 281.6 49 281.1 99.8 49 259.5 92.2 48 226.0 80.3 49
72 290.8 49 287.9 99.0 47 264.1 90.8 47 228.3 78.5 49
76 296.9 49 291.2 98.1 47 269.2 90.7 46 229.6 77.3 49
80 297.2 49 293.4 98.7 45 272.7 91.8 42 229.8 77.3 49
84 299.6 48 295.3 98.6 45 274.9 91.8 41 232.4 77.6 49
88 304.2 45 299.1 98.3 44 278.5 91.6 39 234.2 77.0 49
92 312.3 44 304.4 97.5 42 282.9 90.6 37 232.1 74.3 48
96 313.9 42 305.5 97.3 42 285.0 90.8 33 232.7 74.1 47
100 318.5 41 308.4 96.8 40 284.6 89.4 32 230.7 72.4 45
104 320.6 40 308.5 96.2 39 283.1 88.3 28 227.5 71.0 42
TERM. SAC. 40 39 28 42
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.