TDMS Study 92012-05 Pathology Tables
NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 FINAL#1; REVISION#1 Facility: Southern Research Institute Chemical CAS #: 693-98-1 Lock Date: 10/16/01 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6| DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5| | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + A A| |__________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| Hemorrhage | 2 | Hepatodiaphragmatic Nodule | X X | Infiltration Cellular, Mixed Cell | 1 1 2 1 1 1 2 2 2 2 2 2 2 2 2 1 2 1 2 2| Inflammation, Granulomatous | 1 2 2 2 2 1 1 1 2 2| Mixed Cell Focus | X X X X | Bile Duct, Cyst | X | Bile Duct, Hyperplasia | 1 2 3 1 1 1 2 1 1 | Hepatocyte, Vacuolization | | Cytoplasmic, Focal | 1 1 1 | Hepatocyte, Centrilobular, | | Vacuolization Cytoplasmic | | |__________________________________________________________________________| Mesentery | + + + + + | Fat, Necrosis, Focal | 2 2 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Diffuse | 3 | Acinus, Atrophy, Focal | 2 1 1 2 1 4 1 1 1 | Duct, Cyst, Focal | | Duct, Cyst, Focal, Multiple | 1 2 2 2 2 2 | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6| DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5| | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Epithelium, Hyperplasia | 1 1| |__________________________________________________________________________| Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | Epithelium, Hyperplasia, Focal | 2 | Glands, Ectasia, Focal | | |__________________________________________________________________________| Tongue | + + | Epithelium, Hyperplasia, Focal | 1 | |__________________________________________________________________________| Tooth | | Peridontal Tissue, Inflammation, | | Chronic | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 | Angiectasis | 2 | Cytoplasmic Alteration, Focal | 2 2 1| Vacuolization Cytoplasmic, Focal | 2 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + I + + + + +| Hyperplasia, Focal | 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6| DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5| | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 | Pars Distalis, Cyst | | Pars Distalis, Cytoplasmic | | Alteration, Focal | 1 2 | Pars Distalis, Degeneration, Cystic, | | Focal | 2 3 2 2 | Pars Distalis, Degeneration, Cystic | 2 | Pars Distalis, Hemorrhage, Focal | | Pars Distalis, Hyperplasia, Focal | | Rathke's Cleft, Cyst | 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| C-Cell, Hyperplasia | 2 1 2 2 2 2 2 3 3 2 1 2 2 3 2 1 1 2 2 2 2 2 2 | Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 3 3 | Hyperplasia, Cystic | | Inflammation, Chronic | 3 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Cyst | 1 2 3 | Periovarian Tissue, Cyst | 3 | Periovarian Tissue, Cyst, Multiple | 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6| DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5| | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 2 | |__________________________________________________________________________| Vagina | + | Epithelium, Cyst | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Myeloid Cell, Hyperplasia | 3 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + | Mediastinal, Angiectasis | | Mediastinal, Ectasia | 2 3 | Mediastinal, Hemorrhage | 2 | Mediastinal, Hyperplasia, Histiocytic| 3 3 3 3 3 | Mediastinal, Pigmentation | 2 | Pancreatic, Ectasia | 3 | Pancreatic, Hemorrhage | 2 2 3 | Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 | Pancreatic, Hyperplasia, Plasma Cell | 3 | Pancreatic, Pigmentation | 3 3 2 3 | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M + M M M + + M M M M M M M M M| Ectasia | 3 | |__________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | Hemorrhage | 2 | Hyperplasia, Histiocytic | 3 | Pigmentation | 3 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 | Inflammation, Granulomatous | 2 4 | Pigmentation, Focal | 2| |__________________________________________________________________________| Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6| DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5| | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 2 2 3 2 2 2 4 3 4 2 3 3 3 2 | Ectasia | 3 4| Hyperplasia, Cystic | | Hyperplasia | 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression, Focal | 4 3 4| Hemorrhage, Focal | 3 | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | Hemorrhage, Focal | | Necrosis, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 1 | Hemorrhage, Focal | 2 | Hemorrhage | 1 | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 6| 6| DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 5| 0| 3| 3| 3| 3| 7| 5| | 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 4| 8| 4| 4| 4| 5| 8| 8| 5| 5| 5| 5| 5| 1| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Hyperplasia, Histiocytic | 2 1 1 1 2| Inflammation, Chronic, Focal | | Inflammation, Focal, Granulomatous | 1 | Pigmentation, Focal | 2 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 2 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Nasolacrimal Duct, Inflammation | 3 3 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Cataract | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic, Focal | 2 | Hyperplasia, Focal, Histiocytic | | Hyperplasia, Focal | 1 | |__________________________________________________________________________| Lacrimal Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Accumulation, Hyaline | | Droplet | 2 2 2 2 3 | Renal Tubule, Pigmentation | 2 1 1 1 2| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 7 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3| | | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis, Focal | 2 | 2 2.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 42 | Hemorrhage | 2 | 2 2.0| Hepatodiaphragmatic Nodule | X X X X | 6 | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 1 1 2 2 1 2 1 1 2 2 1 2| 42 1.7| Inflammation, Granulomatous | 3 1 2 2 1 2 1 1 | 18 1.6| Mixed Cell Focus | X X X X X X X X X X X | 15 | Bile Duct, Cyst | X | 2 | Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 1 2 1| 20 1.3| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 2 2 1 3 1 | 9 1.4| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 4 | 1 4.0| |__________________________________________________________________________|____________| Mesentery | + + + | 8 | Fat, Necrosis, Focal | 2 2 | 5 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3| | | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Acinus, Atrophy, Diffuse | | 1 3.0| Acinus, Atrophy, Focal | 1 2 2 2 | 13 1.6| Duct, Cyst, Focal | 2 | 1 2.0| Duct, Cyst, Focal, Multiple | 1 2 2 | 9 1.8| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | 2 | 1 2.0| Epithelium, Hyperplasia | 2 | 3 1.3| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ulcer | | 1 2.0| Epithelium, Hyperplasia, Focal | | 1 2.0| Glands, Ectasia, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Tongue | + | 3 | Epithelium, Hyperplasia, Focal | | 1 1.0| |__________________________________________________________________________|____________| Tooth | + | 1 | Peridontal Tissue, Inflammation, | | | Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | | 5 1.4| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 | 2 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3| | | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Angiectasis | | 1 2.0| Cytoplasmic Alteration, Focal | | 3 1.7| Vacuolization Cytoplasmic, Focal | 2 1 2 1 2 | 8 1.8| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | | 1 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 4 3 2 | 5 2.8| Pars Distalis, Cyst | 3 | 1 3.0| Pars Distalis, Cytoplasmic | | | Alteration, Focal | 1 2 | 4 1.5| Pars Distalis, Degeneration, Cystic, | | | Focal | 2 2 2 3 2 | 9 2.2| Pars Distalis, Degeneration, Cystic | | 1 2.0| Pars Distalis, Hemorrhage, Focal | 1 | 1 1.0| Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0| Rathke's Cleft, Cyst | | 1 3.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 2 2 3 3 3 3 3 3 2 3 1 2 3 3 2 3 2 2 2 2 2 2 2 2 2| 48 2.2| Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 3 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3| | | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Degeneration, Cystic | 2 3 2 | 6 2.5| Hyperplasia, Cystic | 2 | 1 2.0| Inflammation, Chronic | 3 | 2 3.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Cyst | 2 2 | 5 2.0| Periovarian Tissue, Cyst | 3 4 3 | 4 3.3| Periovarian Tissue, Cyst, Multiple | | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 3 2.7| Endometrium, Hyperplasia, Cystic | 2 2 1 2 | 10 1.7| |__________________________________________________________________________|____________| Vagina | + | 2 | Epithelium, Cyst | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| Myeloid Cell, Hyperplasia | 3 | 2 3.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + | 32 | Mediastinal, Angiectasis | 3 | 1 3.0| Mediastinal, Ectasia | 3 3 3 | 5 2.8| Mediastinal, Hemorrhage | 2 | 2 2.0| Mediastinal, Hyperplasia, Histiocytic| 3 3 2 | 8 2.9| Mediastinal, Pigmentation | | 1 2.0| Pancreatic, Ectasia | 1 | 2 2.0| Pancreatic, Hemorrhage | 3 3 | 5 2.6| Pancreatic, Hyperplasia, Histiocytic | 3 3 2 2 3 2 3 3 3 3 2 | 16 2.8| Pancreatic, Hyperplasia, Plasma Cell | | 1 3.0| Pancreatic, Pigmentation | | 4 2.8| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3| | | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M + M M M M + M M M M M M M M| 5 | Ectasia | | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ectasia | | 1 3.0| Hemorrhage | | 1 2.0| Hyperplasia, Histiocytic | 3 | 2 3.0| Pigmentation | | 2 2.5| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3 2 2 | 6 2.2| Inflammation, Granulomatous | 4 | 3 3.3| Pigmentation, Focal | | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + I + + + + +| 48 | Hyperplasia, Lymphoid | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 1 2 2 3 2 4 2 2 2 2 2 2 2 3 2 2 2 2| 33 2.4| Ectasia | | 2 3.5| Hyperplasia, Cystic | 3 | 1 3.0| Hyperplasia | 2 3 | 3 2.3| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3| | | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression, Focal | 2 3 2 3 1 3 4 | 10 2.9| Hemorrhage, Focal | 2 | 2 2.5| |__________________________________________________________________________|____________| Peripheral Nerve | + | 2 | |__________________________________________________________________________|____________| Spinal Cord | + + | 3 | Hemorrhage, Focal | 2 | 1 2.0| Necrosis, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + | 2 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 2 1.5| Hemorrhage, Focal | | 1 2.0| Hemorrhage | | 1 1.0| Hyperplasia, Histiocytic | 1 | 6 1.3| Inflammation, Chronic, Focal | 1 | 1 1.0| Inflammation, Focal, Granulomatous | | 1 1.0| Pigmentation, Focal | | 1 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 1 2 | 7 1.6| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 1 2.0| Nasolacrimal Duct, Inflammation | 3 2 | 4 2.8| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 0| 3| 3| | | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 4| 6| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Cataract | 3 | 1 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic, Focal | | 1 2.0| Hyperplasia, Focal, Histiocytic | 2 | 1 2.0| Hyperplasia, Focal | 1 | 2 1.0| |__________________________________________________________________________|____________| Lacrimal Gland | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 | 38 1.0| Renal Tubule, Accumulation, Hyaline | | | Droplet | 2 2 2 2 2 3 | 11 2.2| Renal Tubule, Pigmentation | 2 1 3 | 8 1.6| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + I + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| Degeneration, Cystic, Focal | 2 | Fatty Change | 3 | Hepatodiaphragmatic Nodule | X X | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| Inflammation, Granulomatous | 4 2 2 2 2 2 2 2 2 2 2 2 2| Mixed Cell Focus | X X X X X | Necrosis, Focal | 2 | Bile Duct, Hyperplasia | 1 2 1 1 2 1 1 1 1 1 2 2 2 1 | Hepatocyte, Vacuolization | | Cytoplasmic, Focal | 2 1 1 1 1 | |__________________________________________________________________________| Mesentery | + + + + + + | Fibrosis | 1 | Inflammation, Chronic | 2 | Fat, Necrosis, Focal | 3 2 3 3 2 3 | Fat, Necrosis | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Diffuse, | | Mixed Cell | | __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Acinus, Atrophy, Diffuse | | Acinus, Atrophy, Focal | 1 1 1 1 1 1 1 1 | Duct, Cyst, Focal, Multiple | 2 2 1 2 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Inflammation, Chronic | 3 | Ulcer | 3 2 | Epithelium, Hyperplasia | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 2 2 2 | Infiltration Cellular, Mixed Cell | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 1 | Angiectasis | | Hematopoietic Cell Proliferation | 2 | Hemorrhage, Focal | | Hemorrhage | | Vacuolization Cytoplasmic, Focal | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 2 2 | Cyst | | Hemorrhage | | Pars Distalis, Cyst | 2 2 | Pars Distalis, Cyst, Multiple | 2 3 | Pars Distalis, Cytoplasmic | | Alteration, Focal | 2 | Pars Distalis, Degeneration, Cystic, | | Focal | 2 3 2 2 3 2 2 2 | Pars Distalis, Hemorrhage, Focal | 3 | Pars Distalis, Hyperplasia, Focal | 2 | Pars Intermedia, Pars Nervosa, | | Atypia Cellular, Focal | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Vacuolization Cytoplasmic, Focal | | C-Cell, Hyperplasia | 3 2 2 2 3 3 2 3 2 2 2 3 3 2 2 2 2 3 2 2 2 2 2 1| Follicle, Cyst | 2 | Follicle, Mineralization, Focal | 3 2 1 1 1 2 1 1 1 1 2 2 3 1 1 2 3 3 3 1 1 1 2 2 2| Follicular Cell, Hyperplasia | 1 2 2 1 1 1 2 1 2 1 2 1 1 2 2 2 2 1 2 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | | Fibrosis, Focal | 2 | Hyperplasia, Cystic | 2 3 | Inflammation, Chronic | 2 3 2 3 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | | __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Cyst | 4 2 3 | Periovarian Tissue, Cyst | 3 4 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic | 1 3 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Histiocytic | 2 | Myeloid Cell, Hyperplasia | 3 | Myeloid Cell, Erythroid Cell, | | Hyperplasia | 3 2 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + +| Mediastinal, Ectasia | 2 3 | Mediastinal, Hemorrhage | | Mediastinal, Hyperplasia, Histiocytic| 3 3 3 3 3 3 2 | Mediastinal, Hyperplasia, Lymphoid | 3 | Mediastinal, Hyperplasia | | Pancreatic, Atrophy | | Pancreatic, Ectasia | 3 | Pancreatic, Hemorrhage | 3 3 | Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 1 3 3 3 3 2 3 3 3 3| Pancreatic, Pigmentation | 2| |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M + M M + M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Histiocytic | 3 | Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | 1 | Angiectasis, Focal | | Congestion | 3 | Fibrosis, Focal | | Hematopoietic Cell Proliferation | 3 2 2 3 2 | __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Inflammation, Granulomatous | 3 | Pigmentation, Focal | 3| Pigmentation | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| Hyperplasia, Lymphoid | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 2 2 2 4 4 2 3 2 2 2 3 2 3 3 1 4 2 2 2 | Ectasia | 3| Fibrosis | 3 | Hyperplasia | 3 2 3 | Inflammation, Focal | 3 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression, Focal | 3 4 3 3 3| Hemorrhage, Focal | | |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 6| 6| 6| 3| 6| 7| 7| 7| 0| 2| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 2 | Hyperplasia, Histiocytic | 1 2| Infiltration Cellular, Mixed Cell | 2 2 | Inflammation, Chronic, Focal | | Alveolar Epithelium, Hyperplasia, | | Focal | 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 2 | Inflammation, Suppurative | 2 | Nasolacrimal Duct, Inflammation | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Cataract | 3 3 | Retina, Degeneration | 3 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Histiocytic | 2 1 | Epithelium, Hyperplasia, Focal | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Accumulation, Hyaline | | Droplet | 2 4 1 1 3| Renal Tubule, Pigmentation | 2| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 20 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| | | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + + + A + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + A + + + + + + A + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + A + + + + + + A + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + A + + + + + + A + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Liver | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Angiectasis, Focal | | 1 2.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 44 | Degeneration, Cystic, Focal | | 1 2.0| Fatty Change | 3 | 2 3.0| Hepatodiaphragmatic Nodule | X X X X X X X X X| 11 | Infiltration Cellular, Mixed Cell | 2 1 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 1| 44 2.0| Inflammation, Granulomatous | 2 2 2 1 1 2 2 3 1 2 | 23 2.0| Mixed Cell Focus | X X X X X X X X X | 14 | Necrosis, Focal | | 1 2.0| Bile Duct, Hyperplasia | 2 2 1 2 1 2 3 2 2 1 1 1 1 1 1| 29 1.4| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 2 2 1 2 | 10 1.4| |__________________________________________________________________________|____________| Mesentery | + + + + | 10 | Fibrosis | | 1 1.0| Inflammation, Chronic | | 1 2.0| Fat, Necrosis, Focal | 3 | 7 2.7| Fat, Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| | | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Diffuse, | | | Mixed Cell | 2 | 1 2.0| Acinus, Atrophy, Diffuse | 4 | 1 4.0| Acinus, Atrophy, Focal | 2 1 2 1 2 1| 14 1.2| Duct, Cyst, Focal, Multiple | 3 2 2 3 2 2 1 | 12 1.9| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | 2 | 1 2.0| Inflammation, Chronic | | 1 3.0| Ulcer | | 2 2.5| Epithelium, Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Erosion | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 3 | |__________________________________________________________________________|____________| Heart | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Cardiomyopathy | 2 2 2 | 8 1.9| Infiltration Cellular, Mixed Cell | 2 1 2 | 4 1.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Accessory Adrenal Cortical Nodule | | 2 1.0| Angiectasis | 3 | 1 3.0| Hematopoietic Cell Proliferation | | 1 2.0| Hemorrhage, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| | | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hemorrhage | 2 | 1 2.0| Vacuolization Cytoplasmic, Focal | 3 1 2 | 3 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | | 1 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + + + + + + A + + + + + + + + + + +| 48 | Angiectasis | 3 2 3 3 2 2 | 9 2.6| Cyst | 3 | 1 3.0| Hemorrhage | 3 | 1 3.0| Pars Distalis, Cyst | 3 | 3 2.3| Pars Distalis, Cyst, Multiple | | 2 2.5| Pars Distalis, Cytoplasmic | | | Alteration, Focal | 1 1 2 | 4 1.5| Pars Distalis, Degeneration, Cystic, | | | Focal | 2 1 2 2 3 1 | 14 2.1| Pars Distalis, Hemorrhage, Focal | 2 3 | 3 2.7| Pars Distalis, Hyperplasia, Focal | | 1 2.0| Pars Intermedia, Pars Nervosa, | | | Atypia Cellular, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + M + + + + + + A + + + + + + + + + + +| 48 | Vacuolization Cytoplasmic, Focal | 1 | 1 1.0| C-Cell, Hyperplasia | 2 2 3 2 2 1 2 3 3 3 2 1 2 2 1 3 3 1 3 2 2 2| 46 2.2| Follicle, Cyst | X | 2 2.0| Follicle, Mineralization, Focal | 1 2 2 3 2 1 1 2 2 2 1 1 2 2 2 1 2 1 1 2 2 2| 47 1.7| Follicular Cell, Hyperplasia | 1 2 1 3 1 1 1 1 1 1 2 2 2 1 1 2 1 2 3 1| 41 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| | | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Cystic | 3 3 4 2 | 4 3.0| Fibrosis, Focal | | 1 2.0| Hyperplasia, Cystic | 3 3 | 4 2.8| Inflammation, Chronic | 1 | 5 2.2| |__________________________________________________________________________|____________| Ovary | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 | 1 2.0| Atrophy | 3 | 1 3.0| Cyst | 3 2 | 5 2.8| Periovarian Tissue, Cyst | 3 3 3 | 5 3.2| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 1 2 1 1 2 | 14 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal, Histiocytic | | 1 2.0| Myeloid Cell, Hyperplasia | 3 2 | 3 2.7| Myeloid Cell, Erythroid Cell, | | | Hyperplasia | | 2 2.5| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + +| 31 | Mediastinal, Ectasia | 3 | 3 2.7| Mediastinal, Hemorrhage | 3 3 3 | 3 3.0| Mediastinal, Hyperplasia, Histiocytic| 3| 8 2.9| Mediastinal, Hyperplasia, Lymphoid | | 1 3.0| Mediastinal, Hyperplasia | 3 | 1 3.0| Pancreatic, Atrophy | 3 | 1 3.0| Pancreatic, Ectasia | 3 | 2 3.0| Pancreatic, Hemorrhage | 3 | 3 3.0| Pancreatic, Hyperplasia, Histiocytic | 1 3 3 3 3 3 3 3 3| 24 2.8| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| | | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Pancreatic, Pigmentation | 3 | 2 2.5| |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M + + M M M M M| 4 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Histiocytic | | 1 3.0| Hyperplasia, Lymphoid | | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Accessory Spleen | | 1 1.0| Angiectasis, Focal | 2 | 1 2.0| Congestion | | 1 3.0| Fibrosis, Focal | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 3 2 | 8 2.4| Inflammation, Granulomatous | 3 | 2 3.0| Pigmentation, Focal | | 1 3.0| Pigmentation | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + M + + + + M + + + + + I + + + M + + + + + + + +| 45 | Hyperplasia, Lymphoid | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 4 2 2 3 2 3 2 3 3 2 2 2 3 3| 35 2.5| Ectasia | 2 2 | 3 2.3| Fibrosis | | 1 3.0| Hyperplasia | 3 2 | 5 2.6| Inflammation, Focal | | 1 3.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| | | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Compression, Focal | 2 3 3 | 8 3.0| Hemorrhage, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Peripheral Nerve | + | 1 | |__________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | | 2 | |__________________________________________________________________________|____________| Lung | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Congestion | 3 2 | 4 2.3| Hyperplasia, Histiocytic | 1 1 1 1 | 6 1.2| Infiltration Cellular, Mixed Cell | 2 | 3 2.0| Inflammation, Chronic, Focal | 1 1 | 2 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 2 2 2 | 5 1.8| |__________________________________________________________________________|____________| Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Foreign Body | | 1 2.0| Inflammation, Suppurative | | 1 2.0| Nasolacrimal Duct, Inflammation | 2 | 2 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 4| 7| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| | | 6| 8| 6| 6| 5| 6| 8| 6| 8| 6| 5| 5| 5| 0| 5| 7| 7| 7| 7| 7| 3| 4| 4| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | |__________________________________________________________________________|____________| Eye | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 3 | 1 3.0| Cataract | | 2 3.0| Retina, Degeneration | | 2 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal, Histiocytic | | 2 1.5| Epithelium, Hyperplasia, Focal | 1 | 2 1.5| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + A + + + + + + A + + + + + + + + + + +| 48 | Atrophy, Focal | 2 2 | 2 2.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 40 1.0| Renal Tubule, Accumulation, Hyaline | | | Droplet | 2 1 | 7 2.0| Renal Tubule, Pigmentation | 1 1 2 | 4 1.5| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5| DAY ON TEST | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + A + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 4 3 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | Congestion, Focal | | Congestion | 2 | Eosinophilic Focus | X | Fatty Change | 2| Hepatodiaphragmatic Nodule | X X X X X X X | Hyperplasia, Focal, Lymphoid | | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | Inflammation, Granulomatous | 2 3 2 1 1 1 2 1 1 1 2 1 1| Mixed Cell Focus | X X X X X X X X | Bile Duct, Cholangiofibrosis, Focal | | Bile Duct, Cyst, Multiple | X | Bile Duct, Hyperplasia | 1 2 2 3 1 1 1 1 | Hepatocyte, Necrosis, Focal | | Hepatocyte, Vacuolization | | Cytoplasmic, Focal | 1 1 2 1 | Hepatocyte, Periportal, | | Vacuolization Cytoplasmic | 2 | Hepatocyte, Centrilobular, Necrosis | 3 | Hepatocyte, Centrilobular, | | Vacuolization Cytoplasmic | 3 | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5| DAY ON TEST | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Mesentery | + + + + | Infiltration Cellular, Mixed Cell | | Fat, Necrosis, Focal | 3 3 | Fat, Necrosis | 3 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Focal | 1 1 2 1 2 | Duct, Cyst, Focal, Multiple | 2 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Inflammation, Chronic | 3| Inflammation, Focal | | Ulcer | 2| Epithelium, Hyperplasia | 3 1 3| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| Erosion | 2 | Inflammation, Chronic | 2| Necrosis, Focal | | Glands, Degeneration, Cystic, Focal | | |__________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 | Infiltration Cellular, Mixed Cell | 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5| DAY ON TEST | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Accessory Adrenal Cortical Nodule | 1 1 | Angiectasis | | Cytoplasmic Alteration, Focal | 1 | Vacuolization Cytoplasmic, Focal | 1 3 3 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 2 2 | Metaplasia, Focal, Lipocyte | | Pars Distalis, Cyst | 2 | Pars Distalis, Cytoplasmic | | Alteration, Focal | 2 | Pars Distalis, Degeneration, Cystic, | | Focal | 2 3 2 3 | Pars Distalis, Hemorrhage, Focal | 4| Pars Distalis, Hyperplasia, Focal | 3 | Pars Distalis, Pigmentation, Focal | | Pars Intermedia, Cyst | | Rathke's Cleft, Cyst | | |__________________________________________________________________________| Thyroid Gland | + + A + + + A + + A + + + + + + + + + A + + + + +| C-Cell, Hyperplasia | 2 3 2 2 1 2 2 1 2 3 2 2 2 2 2 2 1 3 2 2| Follicle, Cyst | X | Follicle, Mineralization, Focal | 3 2 1 2 3 1 1 1 3 2 3 3 3 3 3 1 2 3 3 2| Follicular Cell, Hyperplasia | 2 3 2 2 1 2 2 1 3 2 1 2 1 2 1 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + | Mediastinum, Infiltration Cellular, | | Mixed Cell | | Thoracic, Infiltration Cellular, | | __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5| DAY ON TEST | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | Focal, Mixed Cell | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 | Hyperplasia, Cystic | 3 3 | Inflammation, Chronic | 3 1 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Cyst | | Bilateral, Cyst, Multiple | | Periovarian Tissue, Cyst | 3 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hemorrhage | 2 | Inflammation, Chronic | 3 | Cervix, Hyperplasia | 3 | Endometrium, Hyperplasia, Cystic | 1 2 1 2 1 2 | |__________________________________________________________________________| Vagina | + +| Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | 3 2 3 | Myeloid Cell, Erythroid Cell, | | Hyperplasia | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + | Mediastinal, Congestion | | Mediastinal, Ectasia | 3 | Mediastinal, Hemorrhage | 2 | Mediastinal, Hyperplasia, Histiocytic| 3 3 3 | Mediastinal, Hyperplasia, Lymphoid | 3 | __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5| DAY ON TEST | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Mediastinal, Hyperplasia | 3 | Mediastinal, Pigmentation | 3 | Pancreatic, Hemorrhage | 2 | Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 3 3 3 3 | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M + M M M M M M M + M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +| Angiectasis | 3 | Hemorrhage | 3 | Hyperplasia, Histiocytic | 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| Accessory Spleen | 2 | Fibrosis, Focal | | Hematopoietic Cell Proliferation | 2 | Hemorrhage | 2 | Inflammation, Granulomatous | 3 1 | Pigmentation, Focal | 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 2 4 3 2 2 2 4 2 3 | Ectasia | 4 3 1 2| Hyperplasia, Cystic | 3 2 | Hyperplasia | 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 32 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5| DAY ON TEST | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression, Focal | 3 3 3 3 3 2 3 4| Hemorrhage, Focal | 3 | Necrosis, Focal | 3 | Pigmentation, Focal | | Cerebellum, Developmental | | Malformation | | |__________________________________________________________________________| Peripheral Nerve | + +| |__________________________________________________________________________| Spinal Cord | + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Emphysema | | Hyperplasia, Focal, Histiocytic | | Hyperplasia, Histiocytic | 1 1 1 1| Infiltration Cellular, Mixed Cell | | Inflammation, Chronic, Focal | | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | Interstitium, Edema | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation | 2 3 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + A + + + + + + + + + + + + + + +| Atrophy | | __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 2| 6| 7| 5| 7| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 7| 5| DAY ON TEST | 6| 3| 0| 4| 0| 1| 4| 3| 8| 8| 4| 3| 3| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| | 8| 4| 1| 4| 5| 0| 8| 4| 0| 0| 6| 5| 5| 5| 5| 8| 6| 6| 6| 6| 5| 8| 5| 5| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Cataract | 2 | Iris, Synechia | 3 | Retina, Degeneration | 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Histiocytic | | Hyperplasia, Focal | | Inflammation, Chronic, Focal | 1 2 | Inflammation, Focal, Granulomatous | 1 | Epithelium, Hyperplasia, Focal | 2 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| Atrophy, Focal | | Congestion | 3 | Infarct | | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Pelvis, Inflammation | | Renal Tubule, Accumulation, Hyaline | | Droplet | 1 | Renal Tubule, Pigmentation | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 34 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3| | | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + A A + A + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + A A + A + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + A A + A + + + +| 44 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis, Focal | | 2 3.5| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 43 | Congestion, Focal | 2 | 1 2.0| Congestion | 3 | 2 2.5| Eosinophilic Focus | | 1 | Fatty Change | | 1 2.0| Hepatodiaphragmatic Nodule | X X X X X X X | 14 | Hyperplasia, Focal, Lymphoid | 3 | 1 3.0| Infiltration Cellular, Mixed Cell | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2| 34 1.9| Inflammation, Granulomatous | 1 2 2 2 1 2 1 2 2 | 22 1.5| Mixed Cell Focus | X X X | 11 | Bile Duct, Cholangiofibrosis, Focal | 2 | 1 2.0| Bile Duct, Cyst, Multiple | | 1 | Bile Duct, Hyperplasia | 1 1 2 2 2 1 1 1 2 2 2 1 | 20 1.5| Hepatocyte, Necrosis, Focal | 2 | 1 2.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 1 1 1 1 1 2| 11 1.2| Hepatocyte, Periportal, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3| | | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Vacuolization Cytoplasmic | | 1 2.0| Hepatocyte, Centrilobular, Necrosis | | 1 3.0| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 3 2 4 | 4 3.0| |__________________________________________________________________________|____________| Mesentery | + + + + + + + + | 12 | Infiltration Cellular, Mixed Cell | 2 | 1 2.0| Fat, Necrosis, Focal | 2 3 3 3 | 6 2.8| Fat, Necrosis | 2 | 2 2.5| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Acinus, Atrophy, Focal | 1 1 2 3 2 2 2 2 | 13 1.7| Duct, Cyst, Focal, Multiple | 2 2 | 4 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 2 | 1 2.0| Inflammation, Chronic | | 1 3.0| Inflammation, Focal | 2 | 1 2.0| Ulcer | | 1 2.0| Epithelium, Hyperplasia | 3 | 4 2.5| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Erosion | | 1 2.0| Inflammation, Chronic | | 1 2.0| Necrosis, Focal | 2 | 1 2.0| Glands, Degeneration, Cystic, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3| | | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 1 2 | 7 1.6| Infiltration Cellular, Mixed Cell | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 1 2 | 5 1.2| Angiectasis | 2 | 1 2.0| Cytoplasmic Alteration, Focal | | 1 1.0| Vacuolization Cytoplasmic, Focal | 1 3 1 1 | 7 1.9| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 3 2 3 | 7 2.7| Metaplasia, Focal, Lipocyte | 2 | 1 2.0| Pars Distalis, Cyst | 2 | 2 2.0| Pars Distalis, Cytoplasmic | | | Alteration, Focal | | 1 2.0| Pars Distalis, Degeneration, Cystic, | | | Focal | 2 2 3 2 | 8 2.4| Pars Distalis, Hemorrhage, Focal | 3 2 3 | 4 3.0| Pars Distalis, Hyperplasia, Focal | | 1 3.0| Pars Distalis, Pigmentation, Focal | 2 | 1 2.0| Pars Intermedia, Cyst | 2 | 1 2.0| Rathke's Cleft, Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3| | | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Thyroid Gland | + + + + + + + + + A + + + + + + + A A + A + + + +| 42 | C-Cell, Hyperplasia | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 40 2.0| Follicle, Cyst | | 1 | Follicle, Mineralization, Focal | 3 3 3 1 3 3 3 3 3 3 3 3 3 1 1 1 3 3 3 3 3| 41 2.4| Follicular Cell, Hyperplasia | 2 2 2 2 2 2 1 1 2 2 1 1 1 1 1 2 2| 34 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + + | 4 | Mediastinum, Infiltration Cellular, | | | Mixed Cell | 3 | 1 3.0| Thoracic, Infiltration Cellular, | | | Focal, Mixed Cell | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | | 1 2.0| Hyperplasia, Cystic | 3 | 3 3.0| Inflammation, Chronic | 2 3 | 4 2.3| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Cyst | 2 | 1 2.0| Bilateral, Cyst, Multiple | 4 | 1 4.0| Periovarian Tissue, Cyst | 3 4 | 4 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Hemorrhage | 2 | 2 2.0| Inflammation, Chronic | | 1 3.0| Cervix, Hyperplasia | | 1 3.0| Endometrium, Hyperplasia, Cystic | 2 1 2 2 1 2 2 2 1| 15 1.6| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3| | | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Vagina | | 2 | Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | 3 2| 5 2.6| Myeloid Cell, Erythroid Cell, | | | Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + +| 34 | Mediastinal, Congestion | 3 | 1 3.0| Mediastinal, Ectasia | 3 | 2 3.0| Mediastinal, Hemorrhage | 3 3 3 2 3 3 3 3| 9 2.8| Mediastinal, Hyperplasia, Histiocytic| 3 3| 5 3.0| Mediastinal, Hyperplasia, Lymphoid | | 1 3.0| Mediastinal, Hyperplasia | 3 | 2 3.0| Mediastinal, Pigmentation | 3 | 2 3.0| Pancreatic, Hemorrhage | 3 | 2 2.5| Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 3 3 3| 17 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M M M M M M M M M M M M M M M M M M M M M + M +| 5 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 3.0| Hemorrhage | 3 | 2 3.0| Hyperplasia, Histiocytic | 3 | 2 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Accessory Spleen | | 1 2.0| Fibrosis, Focal | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 3 3 3 | 5 2.6| Hemorrhage | | 1 2.0| Inflammation, Granulomatous | 4 2 | 4 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3| | | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Pigmentation, Focal | | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3 3 2 2 3 2 2 3 4 3 2 3 | 22 2.6| Ectasia | 2 2 2 | 7 2.3| Hyperplasia, Cystic | | 2 2.5| Hyperplasia | 1 3 2| 4 2.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression, Focal | 3 3 3 2| 12 2.9| Hemorrhage, Focal | 3 | 2 3.0| Necrosis, Focal | 3 | 2 3.0| Pigmentation, Focal | 2 | 1 2.0| Cerebellum, Developmental | | | Malformation | 3 | 1 3.0| |__________________________________________________________________________|____________| Peripheral Nerve | + + | 4 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3| | | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Spinal Cord | + + | 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 2 | 2 2.0| Emphysema | 3 | 1 3.0| Hyperplasia, Focal, Histiocytic | 1 | 1 1.0| Hyperplasia, Histiocytic | 1 1 1 | 7 1.0| Infiltration Cellular, Mixed Cell | 3 | 1 3.0| Inflammation, Chronic, Focal | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 2 | 3 1.7| Interstitium, Edema | 3 | 1 3.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nasolacrimal Duct, Inflammation | 2 2 | 4 2.3| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 3 | 1 3.0| Cataract | 1 | 2 1.5| Iris, Synechia | | 1 3.0| Retina, Degeneration | | 1 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal, Histiocytic | 2 | 1 2.0| Hyperplasia, Focal | 2 | 1 2.0| Inflammation, Chronic, Focal | 1 | 3 1.3| Inflammation, Focal, Granulomatous | | 1 1.0| Epithelium, Hyperplasia, Focal | | 2 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 0| 4| 3| 3| 3| 6| 4| 3| 4| 3| 3| 3| 3| | | 5| 5| 5| 6| 5| 8| 6| 6| 6| 2| 4| 4| 2| 8| 2| 6| 6| 5| 8| 6| 1| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + A A + + + + + +| 47 | Atrophy, Focal | 2| 1 2.0| Congestion | 3 | 2 3.0| Infarct | 2 | 1 2.0| Nephropathy | 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 38 1.1| Pelvis, Inflammation | 2| 1 2.0| Renal Tubule, Accumulation, Hyaline | | | Droplet | 3 3 | 3 2.3| Renal Tubule, Pigmentation | 2 3 2 3 | 5 2.2| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Focal | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| Cholangiofibrosis | 2 | Congestion | 4 | Degeneration, Cystic, Focal | | Hemorrhage | | Hepatodiaphragmatic Nodule | X X X X X X X | Hyperplasia, Focal, Lymphoid | 2 | Infarct | X | Infiltration Cellular, Mixed Cell | 2 2 2 2 3 2 2 2 1 2 2 2 2 2 2 2 2 2 2| Inflammation, Granulomatous | 1 4 3 1 2 2 2 2 3 2 2 2 2 1 2 2 3 3 2 3 2 2 2| Mixed Cell Focus | X X X X X X X X X X X X | Necrosis, Focal | | Bile Duct, Cyst, Multiple | X | Bile Duct, Hyperplasia | 2 3 2 2 1 2 2 1 1 2 2 4 1 1 3 2 2 1| Hepatocyte, Necrosis, Focal | 2 | Hepatocyte, Vacuolization | | Cytoplasmic, Focal | 2 1 2 2 2 | Hepatocyte, Centrilobular, Necrosis | 3 | Hepatocyte, Centrilobular, | | Vacuolization Cytoplasmic | 2 | __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Mesentery | + + + +| Hemorrhage, Focal | | Artery, Inflammation, Chronic, Focal | | Fat, Necrosis, Focal | 2 2| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Diffuse | 2 | Acinus, Atrophy, Focal | 3 1 1 1 2 1 | Duct, Cyst, Focal | | Duct, Cyst, Focal, Multiple | 2 2 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Duct, Mineralization, Focal | 3 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | 1 | Edema | 3 | Ulcer | 2 | Epithelium, Hyperplasia | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Glands, Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 | Infiltration Cellular, Mixed Cell | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 1 | Angiectasis | 2 | Cytoplasmic Alteration, Focal | 1 1 1 2 2 | __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Vacuolization Cytoplasmic, Focal | 1 2 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + M M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 | Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | | Pars Distalis, Cytoplasmic | | Alteration, Focal | 2 1 | Pars Distalis, Degeneration, Cystic, | | Focal | 2 2 | Pars Distalis, Hemorrhage, Focal | 2 2 3 | Pars Distalis, Hyperplasia, Focal | | Pars Intermedia, Cyst | 2 2 2 | Pars Intermedia, Degeneration, | | Cystic, Focal | 2 | Pars Intermedia, Hemorrhage | 2 | Rathke's Cleft, Hemorrhage | 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 1 1 1 | Follicle, Mineralization, Focal | 2 3 3 3 2 3 3 3 3 2 3 2 3 2 2 3 3 3 3 3 3 3 3 3 3| Follicular Cell, Hyperplasia | 3 3 2 2 2 3 2 3 3 3 3 3 2 2 2 2 2 2 2 3 2 3 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Pelvic, Hemorrhage, Focal | 3 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Degeneration, Cystic | | Hyperplasia, Cystic | 3 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Periovarian Tissue, Cyst | 4 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Endometrium, Hyperplasia, Cystic | 1 1 2 2 1 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperplasia, Focal, Histiocytic | 2 3 2 2 | Myelofibrosis | 3 | Necrosis | 2 | Myeloid Cell, Hyperplasia | 3 3 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Hemorrhage | | Mediastinal, Ectasia | 3 2 3 4 2 | Mediastinal, Hemorrhage | 3 3 3 | Mediastinal, Hyperplasia, Histiocytic| 3 3 3 3 3 3 3 | Mediastinal, Hyperplasia, Lymphoid | 3 | Pancreatic, Ectasia | 3 3 3 3 3 3 2 | Pancreatic, Hemorrhage | 3 3 3 3 3 3 | Pancreatic, Hyperplasia, Histiocytic | 3 4 3 4 4 3 3 3 3 2 3| Pancreatic, Infiltration Cellular, | | Mixed Cell | 3 | Pancreatic, Pigmentation | | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M + M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 3 | Hemorrhage | 3 3 | Hyperplasia, Histiocytic | | __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Infarct | | Inflammation, Granulomatous | 4 2 3 4 4 3 3 2 4 4 3 3 4 4 3 3 4 4| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 3 2 2 2 2 2 3 | Hyperplasia | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis, Focal | 4 3 | Ulcer | | Subcutaneous Tissue, Angiectasis, | | Focal | | Subcutaneous Tissue, Hemorrhage, | | Focal | | Subcutaneous Tissue, Inflammation, | | Focal, Suppurative | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 1 2 | __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Hemorrhage, Focal | 2 | Hyperplasia, Focal, Histiocytic | | Hyperplasia, Histiocytic | 2 | Infiltration Cellular, Focal, Mixed | | Cell | 2 | Infiltration Cellular, Mixed Cell | 2 2 2 | Inflammation, Focal, Granulomatous | 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | Alveolus, Inflammation, Focal, | | Granulomatous | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Inflammation, Suppurative | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 3 | Retina, Degeneration | 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Histiocytic | 2 1 | Hyperplasia, Focal | 1 | Inflammation, Chronic, Focal | 3 | Epithelium, Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1| Glomerulus, Amyloid Deposition, | | Diffuse | | Renal Tubule, Accumulation, Hyaline | | __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 3| 3| 3| 3| 3| | 6| 6| 6| 6| 6| 6| 9| 6| 6| 6| 8| 5| 5| 5| 5| 9| 9| 9| 5| 9| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Droplet | 2 3 | |__________________________________________________________________________| Urethra | + + | Transitional Epithelium, Hyperplasia,| | Diffuse | 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | 4 2| __________________________________________|__________________________________________________________________________ Page 49 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3 | 1 3.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Necrosis, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 39 | Cholangiofibrosis | | 1 2.0| Congestion | | 1 4.0| Degeneration, Cystic, Focal | 2 2 | 2 2.0| Hemorrhage | 2 2 | 2 2.0| Hepatodiaphragmatic Nodule | X X X X X X | 13 | Hyperplasia, Focal, Lymphoid | | 1 2.0| Infarct | X | 2 | Infiltration Cellular, Mixed Cell | 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2| 38 1.9| Inflammation, Granulomatous | 2 2 2 2 2 4 2 2 2 2 2 2 2 2 3 2 2 2 1 | 42 2.1| Mixed Cell Focus | X X X X X X X X X X X X X X| 26 | Necrosis, Focal | 2 | 1 2.0| Bile Duct, Cyst, Multiple | | 1 | Bile Duct, Hyperplasia | 3 2 2 2 2 3 2 1 2 2 1 1 1 2 1 2 2 2 1 2 2 2| 40 1.9| Hepatocyte, Necrosis, Focal | 2 | 2 2.0| Hepatocyte, Vacuolization | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Cytoplasmic, Focal | 2 1 2 2 | 9 1.8| Hepatocyte, Centrilobular, Necrosis | | 1 3.0| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | | 1 2.0| |__________________________________________________________________________|____________| Mesentery | + + + + + | 9 | Hemorrhage, Focal | 2 | 1 2.0| Artery, Inflammation, Chronic, Focal | 3 | 1 3.0| Fat, Necrosis, Focal | 2 | 3 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy, Diffuse | | 1 2.0| Acinus, Atrophy, Focal | 3 2 2 3 2 | 11 1.9| Duct, Cyst, Focal | 2| 1 2.0| Duct, Cyst, Focal, Multiple | 2 1 | 5 1.8| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Duct, Mineralization, Focal | 2 | 2 2.5| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | 2 | 2 1.5| Edema | | 1 3.0| Ulcer | | 1 2.0| Epithelium, Hyperplasia | 2| 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glands, Hyperplasia, Focal | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 4 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 2 2 | 6 1.7| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Infiltration Cellular, Mixed Cell | 1 | 2 1.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 1 1| 5 1.0| Angiectasis | 2 | 2 2.0| Cytoplasmic Alteration, Focal | | 5 1.4| Vacuolization Cytoplasmic, Focal | 2 1 2 1 1 1 1 3 | 12 1.6| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 3.0| Pars Distalis, Angiectasis | | 1 2.0| Pars Distalis, Cyst | 2 | 1 2.0| Pars Distalis, Cytoplasmic | | | Alteration, Focal | 2 | 3 1.7| Pars Distalis, Degeneration, Cystic, | | | Focal | 2 3 2 | 5 2.2| Pars Distalis, Hemorrhage, Focal | 3 3 3 | 6 2.7| Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0| Pars Intermedia, Cyst | | 3 2.0| Pars Intermedia, Degeneration, | | | Cystic, Focal | | 1 2.0| Pars Intermedia, Hemorrhage | | 1 2.0| Rathke's Cleft, Hemorrhage | 3 | 2 3.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + A + + + + + + A + + + + + +| 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | C-Cell, Hyperplasia | 2 2 2 2 2 2 1 2 1 1 2 2 2| 25 1.7| Follicle, Mineralization, Focal | 3 3 1 3 2 3 3 3 3 2 2 2 3 2 2 3 3 2 3 3 3 3 3| 48 2.7| Follicular Cell, Hyperplasia | 2 2 1 2 3 3 2 1 2 1 1 2 2 1 2 2 1 2 2 2 3 3 2| 46 2.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 2 | Pelvic, Hemorrhage, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 3 | 1 3.0| Hyperplasia, Cystic | | 1 3.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Periovarian Tissue, Cyst | 3 3 3 2 3 | 6 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 1 2.0| Endometrium, Hyperplasia, Cystic | 3 1 2 1 2 2 1 1 2| 15 1.6| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 1 3.0| Hyperplasia, Focal, Histiocytic | | 4 2.3| Myelofibrosis | | 1 3.0| Necrosis | | 1 2.0| Myeloid Cell, Hyperplasia | | 2 3.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 41 | Deep Cervical, Hemorrhage | 3 3 | 2 3.0| Mediastinal, Ectasia | 3 3 | 7 2.9| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Mediastinal, Hemorrhage | 3 3 3 3 2 | 8 2.9| Mediastinal, Hyperplasia, Histiocytic| 3 3 3 3 3 | 12 3.0| Mediastinal, Hyperplasia, Lymphoid | | 1 3.0| Pancreatic, Ectasia | 3 2 3 2 | 11 2.7| Pancreatic, Hemorrhage | 3 3 3 | 9 3.0| Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 3 3 | 18 3.1| Pancreatic, Infiltration Cellular, | | | Mixed Cell | | 1 3.0| Pancreatic, Pigmentation | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 3 | 5 3.0| Hemorrhage | | 2 3.0| Hyperplasia, Histiocytic | 3 3| 2 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 2 2| 4 2.0| Infarct | 3 | 1 3.0| Inflammation, Granulomatous | 4 3 4 2 2 3 4 3 3 | 27 3.3| |__________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Lymphoid | | 2 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 2 3 2 2 2 2 3 2 2 4| 19 2.3| Hyperplasia | 2 2 2| 3 2.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis, Focal | 3 3 | 4 3.3| Ulcer | 4 | 1 4.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Subcutaneous Tissue, Angiectasis, | | | Focal | 2 | 1 2.0| Subcutaneous Tissue, Hemorrhage, | | | Focal | 3 | 1 3.0| Subcutaneous Tissue, Inflammation, | | | Focal, Suppurative | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression, Focal | 4 3 3 2 | 4 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 2 1.5| Hemorrhage, Focal | 3 | 2 2.5| Hyperplasia, Focal, Histiocytic | 3 | 1 3.0| Hyperplasia, Histiocytic | | 1 2.0| Infiltration Cellular, Focal, Mixed | | | Cell | | 1 2.0| Infiltration Cellular, Mixed Cell | 2 2 2| 6 2.0| Inflammation, Focal, Granulomatous | | 1 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 2 2 | 3 2.0| Alveolus, Inflammation, Focal, | | | Granulomatous | 2 | 1 2.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 9| 2| 2| 2| 2| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 6| 2| 9| 9| 9| 6| 6| 6| 6| 4| 2| 4| 5| 5| 5| 7| 7| 7| 5| 7| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Inflammation, Suppurative | 3 | 2 2.5| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cataract | | 1 3.0| Retina, Degeneration | | 1 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal, Histiocytic | 2 1 | 4 1.5| Hyperplasia, Focal | | 1 1.0| Inflammation, Chronic, Focal | | 1 3.0| Epithelium, Hyperplasia, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Nephropathy | 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.1| Glomerulus, Amyloid Deposition, | | | Diffuse | 3 | 1 3.0| Renal Tubule, Accumulation, Hyaline | | | Droplet | 2 3 | 4 2.5| |__________________________________________________________________________|____________| Urethra | | 2 | Transitional Epithelium, Hyperplasia,| | | Diffuse | | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| DAY ON TEST | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3| | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0PPM | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X | Cholangiofibrosis | | Degeneration, Cystic, Focal | 2 2 1 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Hyperplasia, Focal, Lymphoid | | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 3 2 2 2 2 2| Inflammation, Granulomatous | 1 1 2 1 1 1 | Mixed Cell Focus | X X X X X X | Necrosis, Focal | 2 3 | Bile Duct, Hyperplasia | 3 1 3 3 2 3 3 2 2 2 3 4 3 3 3 3 3 3 3 2 3 3 3 3| Hepatocyte, Necrosis, Focal | | Hepatocyte, Vacuolization | | Cytoplasmic, Focal | 2 2 2 2 2 2 2 2 1 2 2| Hepatocyte, Centrilobular, | | Vacuolization Cytoplasmic | 3 3 | Hepatocyte, Midzonal, Vacuolization | | Cytoplasmic | 2 | |__________________________________________________________________________| Mesentery | + + + + + + | Fat, Necrosis, Focal | 3 3 | Fat, Necrosis | 2 | __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| DAY ON TEST | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3| | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0PPM | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Focal | 2 3 1 2 2 2 4 3 2 | Duct, Cyst, Focal, Multiple | 3 3 2| Duct, Cyst | 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Edema | | Inflammation, Focal | 2 | Ulcer | 1 | Epithelium, Hyperplasia | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion, Focal | 2 | Erosion | 2 2 2 | Inflammation, Focal | 2 | Ulcer | 1 1 | Glands, Hyperplasia, Focal | | |__________________________________________________________________________| Tongue | + | |__________________________________________________________________________| Tooth | + | Peridontal Tissue, Inflammation | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 | Thrombosis | 3 | Endocardium, Myocardium, Fibrosis, | | Focal | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| DAY ON TEST | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3| | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0PPM | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Cytoplasmic Alteration, Focal | 2 | Hemorrhage | 2 1 | Vacuolization Cytoplasmic, Focal | 2 2 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 1 | Hyperplasia | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Hyperplasia, Focal | 2 | Bilateral, Hyperplasia, Focal | 2 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1| Pars Distalis, Angiectasis | 3 | Pars Distalis, Cyst | | Pars Distalis, Cytoplasmic | | Alteration, Focal | 1 | Pars Distalis, Degeneration, Cystic, | | Focal | | Pars Distalis, Hyperplasia, Focal | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 2 2 2 2 2 1 2 2 2 1 1 1 1 1 1 1| Follicle, Cyst | | Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Follicular Cell, Atrophy, Focal | | Follicular Cell, Hyperplasia, Cystic,| | Focal | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| DAY ON TEST | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3| | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0PPM | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | |__________________________________________________________________________| Tissue NOS | + + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Penis | + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia, Cystic | | Hyperplasia, Focal | | Inflammation, Chronic | 2 3 | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Inflammation, Chronic | 3 2 3 3 1 | Epithelium, Degeneration, Focal, | | Mucoid | 2 | Epithelium, Hyperplasia, Focal | 2 1 | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 | Mineralization, Focal | | Bilateral, Atrophy | | Germinal Epithelium, Atrophy | 3 | Interstitial Cell, Hyperplasia, Focal| | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + +| Mediastinal, Ectasia | | Mediastinal, Hemorrhage | 3 | __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| DAY ON TEST | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3| | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0PPM | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Mediastinal, Hyperplasia, Histiocytic| | Mediastinal, Hyperplasia, Lymphoid | | Pancreatic, Angiectasis | 3 | Pancreatic, Ectasia | | Pancreatic, Hemorrhage | 3 | Pancreatic, Hyperplasia, Focal, | | Histiocytic | 3 | Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 2 3 3 2| Pancreatic, Pigmentation | | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| Hyperplasia, Histiocytic | | Hyperplasia, Lymphoid | 3| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 3 | Fibrosis, Focal | 3 2 | Hematopoietic Cell Proliferation | 3 3 | Infarct | X | Necrosis, Focal | 4 | Capsule, Fibrosis, Focal | 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + I + + + + + +| Atrophy | 3 | Cyst, Multiple | 4 | Hemorrhage | 3 | Hyperplasia, Lymphoid | 3 3 | Epithelial Cell, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + M + + + + + + + + + M + + + + + + + +| Dilatation | 2 | Hyperplasia | 2 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| DAY ON TEST | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3| | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0PPM | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Fibrosis, Focal | 3 | Hemorrhage, Focal | 2 | Inflammation, Chronic, Focal | 2 | Pinna, Necrosis, Focal | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression, Focal | 3 | Hemorrhage, Focal | 3 | Necrosis, Focal | 3 | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hemorrhage, Focal | 2 | Hyperplasia, Focal, Histiocytic | 2 2 2 | Hyperplasia, Histiocytic | 1 2 1 | Infiltration Cellular, Mixed Cell | 3 | Alveolar Epithelium, Hyperplasia, | | Focal | 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 2 | Inflammation, Suppurative | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 62 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 6| 3| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| DAY ON TEST | 3| 6| 3| 3| 7| 4| 1| 2| 2| 3| 3| 3| 5| 2| 2| 3| 3| 3| 9| 3| 3| 3| 8| 3| 3| | 1| 8| 1| 4| 2| 3| 5| 9| 9| 0| 0| 0| 1| 9| 9| 0| 0| 0| 4| 8| 1| 0| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0PPM | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | | Iris, Hyperplasia | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | 1| Epithelium, Hyperplasia, Focal | 2 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | 3 | Congestion | 2 | Inflammation | 2 | Nephropathy | 1 1 1 3 1 1 1 1 2 1 1 1 1 1 1 1 3 2 1 1 1 1| Renal Tubule, Accumulation, Hyaline | | Droplet | 3 | Renal Tubule, Necrosis, Focal | 2 | Renal Tubule, Pigmentation | 2 3 3 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 63 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2| | | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + M| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + M + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X| 23 | Cholangiofibrosis | 4 | 1 4.0| Degeneration, Cystic, Focal | 2 | 4 1.8| Eosinophilic Focus | X X | 3 | Hepatodiaphragmatic Nodule | X X X X| 6 | Hyperplasia, Focal, Lymphoid | 2 | 1 2.0| Infiltration Cellular, Mixed Cell | 1 2 1 2 2 2 2 2 2 2 2 2 2| 25 2.0| Inflammation, Granulomatous | 1 2 1 1 2 1 | 12 1.3| Mixed Cell Focus | X X X X X X X X | 14 | Necrosis, Focal | | 2 2.5| Bile Duct, Hyperplasia | 3 3 4 1 3 2 2 3 3 2 3 2 3 3 3 4 3 3 2 2 3 2 2 3 3| 49 2.7| Hepatocyte, Necrosis, Focal | 4 | 1 4.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 2 1 2 2 1 1 1 2 2 2 2 2| 23 1.8| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 3 3 2 | 5 2.8| Hepatocyte, Midzonal, Vacuolization | | | Cytoplasmic | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2| | | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + +| 26 | Fat, Necrosis, Focal | 3 3 3 2 3 3 | 8 2.9| Fat, Necrosis | | 1 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy, Focal | 3 2 2 1 2 1 2 1 1 1 1 1 3 | 22 1.9| Duct, Cyst, Focal, Multiple | 2 4 2 | 6 2.7| Duct, Cyst | | 1 1.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | 1 | 1 1.0| Edema | 3 | 1 3.0| Inflammation, Focal | | 1 2.0| Ulcer | 2 | 2 1.5| Epithelium, Hyperplasia | 2 | 2 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion, Focal | | 1 2.0| Erosion | 1 | 4 1.8| Inflammation, Focal | | 1 2.0| Ulcer | | 2 1.0| Glands, Hyperplasia, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Tongue | | 1 | |__________________________________________________________________________|____________| Tooth | | 1 | Peridontal Tissue, Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + +| 16 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2| | | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 | 3 1.7| Thrombosis | | 1 3.0| Endocardium, Myocardium, Fibrosis, | | | Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 2.0| Cytoplasmic Alteration, Focal | 2 | 2 2.0| Hemorrhage | | 2 1.5| Vacuolization Cytoplasmic, Focal | 2 1 1 | 6 1.5| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 1 2 1 | 7 1.3| Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + M + + + + +| 47 | Hyperplasia, Focal | | 1 2.0| Bilateral, Hyperplasia, Focal | | 1 2.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 1.5| Pars Distalis, Angiectasis | 2 2 | 3 2.3| Pars Distalis, Cyst | 2 | 1 2.0| Pars Distalis, Cytoplasmic | | | Alteration, Focal | | 1 1.0| Pars Distalis, Degeneration, Cystic, | | | Focal | 2 | 1 2.0| Pars Distalis, Hyperplasia, Focal | 1 | 2 1.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 66 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2| | | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | C-Cell, Hyperplasia | 2 1 2 2 1 2 2 1 1 3 2 2 2 2 2 2 2 2 2 2 2 2| 41 1.7| Follicle, Cyst | X | 1 | Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0| Follicular Cell, Atrophy, Focal | 1 | 1 1.0| Follicular Cell, Hyperplasia, Cystic,| | | Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | | 1 | |__________________________________________________________________________|____________| Tissue NOS | + + + + | 7 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Penis | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Hyperplasia, Cystic | 3 3 | 2 3.0| Hyperplasia, Focal | 2 | 1 2.0| Inflammation, Chronic | 2 1 | 4 2.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Inflammation, Chronic | 3 1 1 2 1 1 1 1 2 2 | 15 1.8| Epithelium, Degeneration, Focal, | | | Mucoid | | 1 2.0| Epithelium, Hyperplasia, Focal | 1 1 | 4 1.3| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 67 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2| | | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 4 | 5 3.2| Mineralization, Focal | 1 | 1 1.0| Bilateral, Atrophy | 4 3 | 2 3.5| Germinal Epithelium, Atrophy | 2 | 2 2.5| Interstitial Cell, Hyperplasia, Focal| 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +| 39 | Mediastinal, Ectasia | 3 | 1 3.0| Mediastinal, Hemorrhage | | 1 3.0| Mediastinal, Hyperplasia, Histiocytic| 2 3 | 2 2.5| Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0| Pancreatic, Angiectasis | | 1 3.0| Pancreatic, Ectasia | 3 | 1 3.0| Pancreatic, Hemorrhage | | 1 3.0| Pancreatic, Hyperplasia, Focal, | | | Histiocytic | | 1 3.0| Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 | 13 2.8| Pancreatic, Pigmentation | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M + M M M M M M + M M M M| 2 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + M + + + +| 47 | Hyperplasia, Histiocytic | 3 | 1 3.0| Hyperplasia, Lymphoid | 3 | 2 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Angiectasis, Focal | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 68 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2| | | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Fibrosis, Focal | | 2 2.5| Hematopoietic Cell Proliferation | 2 2 | 4 2.5| Infarct | | 1 | Necrosis, Focal | | 1 4.0| Capsule, Fibrosis, Focal | | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Atrophy | | 1 3.0| Cyst, Multiple | | 1 4.0| Hemorrhage | | 1 3.0| Hyperplasia, Lymphoid | | 2 3.0| Epithelial Cell, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Dilatation | 2 2 2 2 3 2 | 7 2.1| Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis, Focal | | 1 3.0| Hemorrhage, Focal | | 1 2.0| Inflammation, Chronic, Focal | | 1 2.0| Pinna, Necrosis, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 69 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2| | | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Compression, Focal | 3 3 3 | 4 3.0| Hemorrhage, Focal | 2 | 2 2.5| Necrosis, Focal | | 1 3.0| |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Hemorrhage, Focal | | 1 2.0| Hyperplasia, Focal, Histiocytic | 3 | 4 2.3| Hyperplasia, Histiocytic | | 3 1.3| Infiltration Cellular, Mixed Cell | 2 | 2 2.5| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 | 2 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 2.0| Inflammation, Suppurative | 2 | 2 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Cataract | 3 | 1 3.0| Iris, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic, Focal | | 1 1.0| Epithelium, Hyperplasia, Focal | 1 | 3 1.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 70 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 8| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 3| 3| 9| 2| 2| 2| 3| 3| 9| 2| 1| 2| | | 4| 4| 9| 0| 0| 3| 0| 0| 1| 6| 2| 9| 9| 4| 4| 6| 9| 9| 9| 1| 4| 4| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Accumulation, Hyaline Droplet | | 1 3.0| Congestion | | 1 2.0| Inflammation | | 1 2.0| Nephropathy | 1 1 1 1 2 2 1 1 3 1 1 1 2 2 2 1 1 1 2 2 1| 43 1.3| Renal Tubule, Accumulation, Hyaline | | | Droplet | | 1 3.0| Renal Tubule, Necrosis, Focal | | 1 2.0| Renal Tubule, Pigmentation | 3 | 5 2.8| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 71 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X| Degeneration, Cystic, Focal | 1 | Hepatodiaphragmatic Nodule | X X X | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| Inflammation, Granulomatous | 2 1 1 2 | Mixed Cell Focus | X X X X X X X X| Bile Duct, Hyperplasia | 3 3 3 2 3 2 3 3 2 3 3 2 2 3 3 3 2 1 3 3 3 2 2 3 3| Hepatocyte, Necrosis, Focal | 1 | Hepatocyte, Vacuolization | | Cytoplasmic, Diffuse | 2 | Hepatocyte, Vacuolization | | Cytoplasmic, Focal | 2 1 2 1 2 2 2 1 2 2 2 2 2 2 2 2| Hepatocyte, Centrilobular, Necrosis | 2 | Hepatocyte, Centrilobular, | | Vacuolization Cytoplasmic | 3 | Hepatocyte, Midzonal, Vacuolization | | Cytoplasmic | | Serosa, Fibrosis, Focal | 2 3| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +| Fat, Necrosis, Focal | 3 3 2 1 | Fat, Necrosis | | __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| Acinus, Atrophy, Diffuse | 4 | Acinus, Atrophy, Focal | 2 1 3 3 2 1 3 1 1 1 3 2 3 2 1 1| Duct, Cyst, Focal | | Duct, Cyst, Focal, Multiple | | Duct, Hyperplasia, Cystic, Focal | 2 2 | Duct, Hyperplasia, Cystic | 2| Duct, Hyperplasia, Focal | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Erosion | 2 | Ulcer | | Epithelium, Hyperplasia | 3 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Glands, Hyperplasia, Cystic, Focal | | |__________________________________________________________________________| Tongue | | |__________________________________________________________________________| Tooth | | Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 | Infiltration Cellular, Mixed Cell | | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 | Cytoplasmic Alteration, Focal | | Vacuolization Cytoplasmic, Focal | 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hyperplasia, Focal | 2 3 2 2 2 | Hyperplasia | | Infiltration Cellular, Lymphoid | 2 | Vacuolization Cytoplasmic, Focal | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| Atrophy | 3 | Hyperplasia, Focal | 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Cyst | 3 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 3 | Pars Distalis, Cyst | 2 | Pars Distalis, Cytoplasmic | | Alteration, Focal | 2 1 | Pars Distalis, Degeneration, Cystic, | | Focal | | Pars Distalis, Hyperplasia, Focal | | Pars Distalis, Pars Intermedia, | | Angiectasis | 3 | Pars Intermedia, Cyst | 1 | Pars Intermedia, Hyperplasia, Focal | 1 | |__________________________________________________________________________| Thyroid Gland | + A + + + + + + + + + A + + + + + + + + + + + + +| Cyst | X | C-Cell, Hyperplasia | 2 2 2 1 1 2 2 1 2 2 1 1 1 2 2 2 3 2 2 2 2 2 2| Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 | __________________________________________|__________________________________________________________________________| Page 74 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | |__________________________________________________________________________| Tissue NOS | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Granuloma Sperm | | Inflammation, Chronic | | |__________________________________________________________________________| Penis | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | Inflammation, Chronic | 2 1 1 1 2 1 2 | Inflammation, Suppurative | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Inflammation, Chronic | 1 2 1 3 2 | Epithelium, Hyperplasia, Focal | 2 1 | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 4 | Bilateral, Atrophy | 3 4 | Germinal Epithelium, Atrophy | 3 | Interstitial Cell, Hyperplasia, Focal| 1 2 1 | Interstitial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hyperplasia, Focal, Histiocytic | 3 | Hyperplasia | 3 | Myeloid Cell, Hyperplasia | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Angiectasis | 3 | Mediastinal, Hemorrhage | 3 | Mediastinal, Hyperplasia, Histiocytic| | Mediastinal, Hyperplasia, Lymphoid | 1 | Mediastinal, Pigmentation | | Pancreatic, Ectasia | 3 | Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 3 3 3| |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 3 | Hyperplasia, Histiocytic | 3 | Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +| Cyst | X | Hematopoietic Cell Proliferation | 2 | Hyperplasia, Lymphoid | 2 | Infarct | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + I + + + + + +| Atrophy | | Hyperplasia, Lymphoid | | Epithelial Cell, Cyst, Multiple | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Dilatation | | Epithelium, Pigmentation | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Angiectasis, Focal | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression, Focal | 2 | Hemorrhage, Focal | | Necrosis, Focal | | |__________________________________________________________________________| Peripheral Nerve | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Histiocytic | 2 | Hyperplasia, Histiocytic | 2 | Infiltration Cellular, Mixed Cell | 2 | Metaplasia, Focal, Osseous | 1 2 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 1 1 2 2| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation, | | Chronic | 2 | Nasolacrimal Duct, Inflammation | 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 2 3 | Sinus, Foreign Body | | Sinus, Inflammation, Suppurative | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 2| 3| 3| 3| 3| 2| 2| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | 5| 9| 1| 0| 0| 0| 9| 9| 9| 4| 4| 8| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 300 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Cornea, Inflammation, Focal | | Cornea, Necrosis, Focal | | Lens, Cataract | | Retrobulbar, Inflammation, Focal | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +| Congestion | | Cyst | 2 | Infarct | 3 | Nephropathy | 2 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Accumulation, Hyaline | | Droplet | 1 | Renal Tubule, Pigmentation | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 78 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| | DAY ON TEST | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3| | | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 300 PPM | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + A + + + + A + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + A + + + + A + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + A + + + + A + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X| 23 | Degeneration, Cystic, Focal | 1 2| 3 1.3| Hepatodiaphragmatic Nodule | X X | 5 | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 1 2 1 | 30 1.9| Inflammation, Granulomatous | 1 1 1 1 1 1 1 | 11 1.2| Mixed Cell Focus | X X X X X X X X | 16 | Bile Duct, Hyperplasia | 3 1 3 4 3 3 3 2 2 1 3 2 3 3 3 3 3 2 3 1 3 3 3 3| 49 2.6| Hepatocyte, Necrosis, Focal | | 1 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Diffuse | | 1 2.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 2 2 2 2 2 2 1 2 2 2 2 1 2 2 | 30 1.8| Hepatocyte, Centrilobular, Necrosis | 3 | 2 2.5| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 3 3 2 | 4 2.8| Hepatocyte, Midzonal, Vacuolization | | | Cytoplasmic | 2 | 1 2.0| Serosa, Fibrosis, Focal | | 2 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 79 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| | DAY ON TEST | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3| | | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 300 PPM | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + + +| 46 | Fat, Necrosis, Focal | 3 3 3 3 3 3| 10 2.7| Fat, Necrosis | 3 | 1 3.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy, Diffuse | | 1 4.0| Acinus, Atrophy, Focal | 2 3 1 2 1 2 2 1 1 2 3| 27 1.9| Duct, Cyst, Focal | 4 | 1 4.0| Duct, Cyst, Focal, Multiple | 2 2 | 2 2.0| Duct, Hyperplasia, Cystic, Focal | | 2 2.0| Duct, Hyperplasia, Cystic | | 1 2.0| Duct, Hyperplasia, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | 1 | 1 1.0| Erosion | | 1 2.0| Ulcer | 2 | 1 2.0| Epithelium, Hyperplasia | 3 | 3 2.7| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 | 1 1.0| Glands, Hyperplasia, Cystic, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Tongue | + + | 2 | |__________________________________________________________________________|____________| Tooth | + | 1 | Malformation | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + +| 40 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| | DAY ON TEST | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3| | | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 300 PPM | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 2 2 | 5 1.6| Infiltration Cellular, Mixed Cell | 2 | 1 2.0| Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 1 1 | 4 1.3| Cytoplasmic Alteration, Focal | 1 | 1 1.0| Vacuolization Cytoplasmic, Focal | 1 1 1 2 1 1 2 | 9 1.4| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Hyperplasia, Focal | | 5 2.2| Hyperplasia | 1 | 1 1.0| Infiltration Cellular, Lymphoid | | 1 2.0| Vacuolization Cytoplasmic, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| Hyperplasia, Focal | 2 | 2 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 1 3.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | | 2 2.5| Pars Distalis, Cyst | 1 1 1 | 4 1.3| Pars Distalis, Cytoplasmic | | | Alteration, Focal | 2 2 | 4 1.8| Pars Distalis, Degeneration, Cystic, | | | Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| | DAY ON TEST | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3| | | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 300 PPM | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0| Pars Distalis, Pars Intermedia, | | | Angiectasis | | 1 3.0| Pars Intermedia, Cyst | 2 | 2 1.5| Pars Intermedia, Hyperplasia, Focal | | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + A + + + + + + A + + + + + + + + + + + + + +| 46 | Cyst | | 1 | C-Cell, Hyperplasia | 1 2 3 2 2 1 2 1 2 1 2 2 2 1 1 1 2 2 2 1| 43 1.7| Follicle, Mineralization, Focal | 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0| Follicular Cell, Hyperplasia | 1 1 1 1 2 1 1| 17 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + | 3 | |__________________________________________________________________________|____________| Tissue NOS | | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Granuloma Sperm | 2 | 1 2.0| Inflammation, Chronic | 3 | 1 3.0| |__________________________________________________________________________|____________| Penis | + | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic, Focal | 1 | 1 1.0| Inflammation, Chronic | 1 3 2 | 10 1.6| Inflammation, Suppurative | 3 | 1 3.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| | DAY ON TEST | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3| | | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 300 PPM | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 | 1 1.0| Inflammation, Chronic | 3 1 2 2 2 | 10 1.9| Epithelium, Hyperplasia, Focal | | 2 1.5| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 4| 4 3.8| Bilateral, Atrophy | 3 | 3 3.3| Germinal Epithelium, Atrophy | 3 4 | 3 3.3| Interstitial Cell, Hyperplasia, Focal| 2 | 4 1.5| Interstitial Cell, Hyperplasia | 1 2 | 2 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal, Histiocytic | | 1 3.0| Hyperplasia | | 1 3.0| Myeloid Cell, Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mediastinal, Angiectasis | | 1 3.0| Mediastinal, Hemorrhage | | 1 3.0| Mediastinal, Hyperplasia, Histiocytic| 3 | 1 3.0| Mediastinal, Hyperplasia, Lymphoid | | 1 1.0| Mediastinal, Pigmentation | 3 | 1 3.0| Pancreatic, Ectasia | 3 3 | 3 3.0| Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 | 12 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M + M M M M| 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 2 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| | DAY ON TEST | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3| | | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 300 PPM | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hyperplasia, Histiocytic | 3 | 2 3.0| Hyperplasia, Lymphoid | | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 1 | Hematopoietic Cell Proliferation | 2 3 3 | 4 2.5| Hyperplasia, Lymphoid | | 1 2.0| Infarct | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Atrophy | 3 | 1 3.0| Hyperplasia, Lymphoid | 3 | 1 3.0| Epithelial Cell, Cyst, Multiple | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M + + + + + + + + + + + + + + + + + + + + + + +| 47 | Dilatation | 2 | 1 2.0| Epithelium, Pigmentation | 2 | 1 2.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis, Focal | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression, Focal | 3 | 2 2.5| Hemorrhage, Focal | 3 4 3 | 3 3.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 84 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| | DAY ON TEST | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3| | | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 300 PPM | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Necrosis, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Peripheral Nerve | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal, Histiocytic | | 1 2.0| Hyperplasia, Histiocytic | 1 2 | 3 1.7| Infiltration Cellular, Mixed Cell | | 1 2.0| Metaplasia, Focal, Osseous | | 2 1.5| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 2 2 1| 9 1.6| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nasolacrimal Duct, Inflammation, | | | Chronic | | 1 2.0| Nasolacrimal Duct, Inflammation | 2 | 2 2.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | | 3 2.3| Sinus, Foreign Body | 3 | 1 3.0| Sinus, Inflammation, Suppurative | 3 | 1 3.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Cornea, Inflammation, Focal | 2 | 1 2.0| Cornea, Necrosis, Focal | 1 | 1 1.0| Lens, Cataract | 2 | 1 2.0| Retrobulbar, Inflammation, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 85 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| | DAY ON TEST | 2| 0| 2| 7| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 3| 6| 3| | | 9| 7| 9| 2| 4| 4| 4| 0| 0| 0| 1| 8| 0| 1| 1| 3| 0| 0| 0| 4| 8| 4| 1| 0| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 300 PPM | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L | | 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 1.0| |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Congestion | 3 | 1 3.0| Cyst | 3 | 2 2.5| Infarct | | 1 3.0| Nephropathy | 1 3 1 2 1 1 1 1 2 1 2 1 2 1 2 1 3 1 1 2 1| 43 1.3| Renal Tubule, Accumulation, Hyaline | | | Droplet | | 1 1.0| Renal Tubule, Pigmentation | 2 3 | 3 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 86 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + A + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 3 | Basophilic Focus | X X X X X | Congestion | | Degeneration, Cystic, Focal | 2 | Eosinophilic Focus | X X X X | Fibrosis, Focal | 3 | Hepatodiaphragmatic Nodule | X X| Hyperplasia, Focal, Lymphoid | | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 1 2 2 2 2 2 2| Inflammation, Granulomatous | 2 1 2 | Mixed Cell Focus | X X X X X X X X X X X| Necrosis, Focal | 3 2 | Pigmentation, Focal | 3 2 | Bile Duct, Hyperplasia | 3 3 2 3 3 2 3 3 3 3 2 2 3 3 3 2 4 3 3 2 3 2 2 3| Centrilobular, Congestion | | Hepatocyte, Necrosis, Focal | 2 2 | Hepatocyte, Vacuolization | | Cytoplasmic, Focal | 2 3 2 2 2 2 1 2 1 1 2 1 1 2| Hepatocyte, Centrilobular, Necrosis | | Hepatocyte, Midzonal, Vacuolization | | Cytoplasmic | 3 | __________________________________________|__________________________________________________________________________| Page 87 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + +| Fat, Necrosis, Focal | 2 2 3 3 3 3 4 2 3 | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Diffuse | | Atrophy, Focal | 2 | Acinus, Atrophy, Focal | 2 2 2 2 1 1 4 1 2 | Acinus, Hyperplasia, Focal | 3 | Duct, Cyst, Focal, Multiple | 2 | Duct, Hyperplasia, Cystic, Focal | 2 2 2 | Duct, Hyperplasia, Cystic | 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | 1 | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion, Focal | 3 | Erosion | | |__________________________________________________________________________| Tooth | + | Peridontal Tissue, Inflammation, | | Focal, Suppurative | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Focal | | Cardiomyopathy | 2 2 2 | Congestion | 3 | __________________________________________|__________________________________________________________________________| Page 88 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 1 1 1 | Cytoplasmic Alteration, Focal | | Degeneration, Cystic, Focal | | Vacuolization Cytoplasmic, Focal | 1 1 1 2 2 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Hyperplasia, Focal | 3 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | 3 2 | Pars Distalis, Cytoplasmic | | Alteration, Focal | 1 | Pars Distalis, Degeneration, Cystic, | | Focal | | Pars Distalis, Inflammation, Chronic,| | Focal, Granulomatous | 2 | Pars Intermedia, Hemorrhage | | Pars Nervosa, Infiltration Cellular, | | Focal, Mixed Cell | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + A + + + + + + + + A + + A + +| C-Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 2 1 2 1 2 1 1 2 3 1 1| Follicle, Mineralization, Focal | 1 1 1 1 1 1 3 1 1 3 3 3 3 1 2 3 1 2 2 1 2 3| Follicular Cell, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + + | __________________________________________|__________________________________________________________________________| Page 89 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | Inflammation, Chronic | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 3 | Hyperplasia | | Inflammation, Chronic | 2 2 2 1 2 2 | Inflammation, Suppurative | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 1 1 1 1 2 | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 | Bilateral, Atrophy | 3 | Germinal Epithelium, Atrophy | | Interstitial Cell, Hyperplasia, Focal| 2 2 | Interstitial Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + A + +| Fibrosis | | Hyperplasia, Focal, Histiocytic | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Mediastinal, Congestion | | Mediastinal, Ectasia | 3 | Mediastinal, Hemorrhage | 3 3 | Mediastinal, Hyperplasia, Lymphoid | 3 | Pancreatic, Ectasia | 3 | __________________________________________|__________________________________________________________________________| Page 90 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Pancreatic, Hemorrhage | 2 | Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 3 3 3| Pancreatic, Hyperplasia, Lymphoid | | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| Hyperplasia, Plasma Cell | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Histiocytic | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Fibrosis, Focal | 2 | Hematopoietic Cell Proliferation | | Hemorrhage | | Hyperplasia, Lymphoid | 3 | Inflammation, Granulomatous | 3 | Necrosis, Focal | 2 | Pigmentation | | |__________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + M + + + + + +| Hyperplasia, Lymphoid | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + I + + + + + M M + + +| Dilatation | 2 | Ectasia | 3 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Inflammation, Chronic, Focal | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 91 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression, Focal | 2 | Hemorrhage, Focal | 3 | |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | Hemorrhage, Focal | | Mineralization, Focal | | Necrosis, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage, Focal | | Hyperplasia, Histiocytic | 1 | Infiltration Cellular, Mixed Cell | | Metaplasia, Focal, Osseous | 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 1 1 | Interstitium, Edema | 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | Nasolacrimal Duct, Inflammation | 3 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + A + + A + +| __________________________________________|__________________________________________________________________________| Page 92 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 3| 1| 1| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Cataract | | Synechia | | Retina, Degeneration | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Histiocytic | 2 | Inflammation, Chronic, Focal | 1 | |__________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 2 2 1 1| Pelvis, Inflammation, Chronic | 3 | Pelvis, Transitional Epithelium, | | Hyperplasia | 3 | Renal Tubule, Accumulation, Hyaline | | Droplet | 3 | Renal Tubule, Pigmentation | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________|__________________________________________________________________________ Page 93 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | Angiectasis, Focal | | 1 2.0| |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A A + + + + + + + + + A + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A A + + A + + + + + + A + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A A + + + + + + + + + A + + + + + + +| 45 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis, Focal | | 1 3.0| Basophilic Focus | X X X | 8 | Congestion | 3 3 | 2 3.0| Degeneration, Cystic, Focal | 2 | 2 2.0| Eosinophilic Focus | X X | 6 | Fibrosis, Focal | | 1 3.0| Hepatodiaphragmatic Nodule | X X | 4 | Hyperplasia, Focal, Lymphoid | 2 2 | 2 2.0| Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 | 27 1.9| Inflammation, Granulomatous | 2 | 4 1.8| Mixed Cell Focus | X X X X X X X X X X X X | 23 | Necrosis, Focal | | 2 2.5| Pigmentation, Focal | | 2 2.5| Bile Duct, Hyperplasia | 2 3 3 3 3 3 2 3 4 3 2 1 3 3 1 3 3 2 3 3 3 3 2| 47 2.7| Centrilobular, Congestion | 3 | 1 3.0| Hepatocyte, Necrosis, Focal | 2| 3 2.0| Hepatocyte, Vacuolization | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 94 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Cytoplasmic, Focal | 1 1 2 2 2 2 1 2 2 2 2 2 | 26 1.7| Hepatocyte, Centrilobular, Necrosis | 2 3 | 2 2.5| Hepatocyte, Midzonal, Vacuolization | | | Cytoplasmic | 2 | 2 2.5| |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + +| 35 | Fat, Necrosis, Focal | 3 2 3 2 3 3 3 | 16 2.8| Fat, Necrosis | 2 3| 2 2.5| |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Diffuse | 3 | 1 3.0| Atrophy, Focal | | 1 2.0| Acinus, Atrophy, Focal | 1 2 2 3 2 2 3 3 3 1 1 | 20 2.0| Acinus, Hyperplasia, Focal | | 1 3.0| Duct, Cyst, Focal, Multiple | 2 2 2 2 | 5 2.0| Duct, Hyperplasia, Cystic, Focal | | 3 2.0| Duct, Hyperplasia, Cystic | | 1 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | 2 | 2 1.5| Ulcer | 2 | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion, Focal | | 1 3.0| Erosion | 2| 1 2.0| |__________________________________________________________________________|____________| Tooth | | 1 | Peridontal Tissue, Inflammation, | | | Focal, Suppurative | | 1 3.0| _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 95 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + | 20 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Focal | 2 2 | 2 2.0| Cardiomyopathy | 2 2 2 2 2 2 2 | 10 2.0| Congestion | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 1 1 1 2 | 9 1.1| Cytoplasmic Alteration, Focal | 1 | 1 1.0| Degeneration, Cystic, Focal | 2 | 1 2.0| Vacuolization Cytoplasmic, Focal | 2 1 1 | 10 1.3| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 1 | 3 1.3| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 3.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Hyperplasia, Focal | | 1 3.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 4 | 3 2.7| Pars Distalis, Angiectasis | 2 | 2 2.0| Pars Distalis, Cyst | | 2 2.5| Pars Distalis, Cytoplasmic | | | Alteration, Focal | 2 | 2 1.5| Pars Distalis, Degeneration, Cystic, | | | Focal | 2 | 1 2.0| Pars Distalis, Inflammation, Chronic,| | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 96 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Focal, Granulomatous | | 1 2.0| Pars Intermedia, Hemorrhage | 2 | 1 2.0| Pars Nervosa, Infiltration Cellular, | | | Focal, Mixed Cell | | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + A A + + A + + + + + + A + + + + + + +| 43 | C-Cell, Hyperplasia | 1 2 1 1 2 1 1 3 2 2 1 2 2 2 2 2 2 2| 38 1.5| Follicle, Mineralization, Focal | 1 3 1 3 1 1 1 3 1 3 2 3 1 2 3 3 1 1 3 2 1| 43 1.9| Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 | 37 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + + + | 6 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 4 | 1 4.0| Inflammation, Chronic | 2 | 1 2.0| |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 3 | 2 3.0| Hyperplasia | 2 | 1 2.0| Inflammation, Chronic | 2 1 1 2 | 10 1.7| Inflammation, Suppurative | 3 | 1 3.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 1 2 2 2 1 2 2 2 2 1 | 17 1.6| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 97 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Atrophy | 3 4 3 3 3 3 | 13 3.1| Bilateral, Atrophy | 3 | 2 3.0| Germinal Epithelium, Atrophy | 3 | 1 3.0| Interstitial Cell, Hyperplasia, Focal| 1 1| 4 1.5| Interstitial Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 | Fibrosis | 3 | 1 3.0| Hyperplasia, Focal, Histiocytic | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 42 | Hyperplasia, Lymphoid | 3 | 1 3.0| Mediastinal, Congestion | 4 | 1 4.0| Mediastinal, Ectasia | 3 3 | 3 3.0| Mediastinal, Hemorrhage | 3 3 3| 5 3.0| Mediastinal, Hyperplasia, Lymphoid | | 1 3.0| Pancreatic, Ectasia | 3 2 | 3 2.7| Pancreatic, Hemorrhage | | 1 2.0| Pancreatic, Hyperplasia, Histiocytic | 3 3 2 3 3 2 3 | 15 2.9| Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M + M M M M M M M M M + M M| 2 | Hyperplasia, Plasma Cell | 4 | 1 4.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3| 1 3.0| Hyperplasia, Histiocytic | 3 | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis, Focal | | 1 2.0| Fibrosis, Focal | 3 | 2 2.5| Hematopoietic Cell Proliferation | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 98 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hemorrhage | 3 | 1 3.0| Hyperplasia, Lymphoid | 2 | 2 2.5| Inflammation, Granulomatous | 3 | 2 3.0| Necrosis, Focal | | 1 2.0| Pigmentation | 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + A + + + + + + + M I + + + + + + + M| 44 | Hyperplasia, Lymphoid | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + M| 45 | Dilatation | 3 2 | 3 2.3| Ectasia | | 1 3.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | Inflammation, Chronic, Focal | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression, Focal | 3 4 3 | 4 3.0| Hemorrhage, Focal | 3| 2 3.0| |__________________________________________________________________________|____________| Peripheral Nerve | +| 1 | |__________________________________________________________________________|____________| Spinal Cord | +| 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 99 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Hemorrhage, Focal | 3| 1 3.0| Mineralization, Focal | 2| 1 2.0| Necrosis, Focal | 3| 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + | 1 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Hemorrhage, Focal | 3| 1 3.0| Hyperplasia, Histiocytic | 1 | 2 1.0| Infiltration Cellular, Mixed Cell | 3 | 1 3.0| Metaplasia, Focal, Osseous | | 1 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 2 2 2 2 | 6 1.7| Interstitium, Edema | | 1 2.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 2.0| Nasolacrimal Duct, Inflammation | | 1 3.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + A + + + + + + A + + + + + + +| 46 | Cataract | 2 | 1 2.0| Synechia | 3 | 1 3.0| Retina, Degeneration | 3 | 1 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Hyperplasia, Histiocytic | | 1 2.0| Inflammation, Chronic, Focal | 1 | 2 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 100 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 3| 4| 5| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 9| 9| 3| 3| 3| 7| 6| 2| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 4| 0| 0| 2| 9| 8| 0| 7| 6| 4| 0| 0| 0| 1| 8| 9| 4| 4| 4| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | |__________________________________________________________________________|____________| Zymbal's Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Nephropathy | 1 2 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 2| 41 1.2| Pelvis, Inflammation, Chronic | | 1 3.0| Pelvis, Transitional Epithelium, | | | Hyperplasia | | 1 3.0| Renal Tubule, Accumulation, Hyaline | | | Droplet | 2 4 | 3 3.0| Renal Tubule, Pigmentation | 2 | 2 2.5| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Hemorrhage | 3| 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 101 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3| | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3000 PPM | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Cholangiofibrosis | 2 | Congestion | 3 | Degeneration, Cystic, Focal | 1 2 2 2 2 | Eosinophilic Focus | X | Hematopoietic Cell Proliferation | 1 | Hepatodiaphragmatic Nodule | X X X X | Hyperplasia, Focal, Lymphoid | 3 | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2| Inflammation, Granulomatous | 1 1 1 3 1 1 | Mixed Cell Focus | X X X X X X X X X X X| Necrosis, Focal | | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 3 2 2 2 3 3 3 3 3 3 3 3 4 2 3 3 3 2 3 3 3 3 3 3 3| Hepatocyte, Necrosis, Focal | 2 | Hepatocyte, Vacuolization | | Cytoplasmic, Diffuse | | Hepatocyte, Vacuolization | | Cytoplasmic, Focal | 1 2 2 2 2 1 1 1 2 1 2| Hepatocyte, Centrilobular, | | Vacuolization Cytoplasmic | 2 3 | Oval Cell, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________| Page 102 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3| | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3000 PPM | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + +| Fibrosis, Focal | 3| Hemorrhage | 3| Necrosis, Focal | 3| Artery, Inflammation, Chronic | 3 | Fat, Necrosis, Focal | 3 2 3 3 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | 2 | Fibrosis, Focal | | Acinus, Atrophy, Diffuse | | Acinus, Atrophy, Focal | 2 2 3 2 1 1 3 1 2 1 2 3 2 1 2 1 2 2 1 | Duct, Cyst, Focal, Multiple | 2 2 2 2 2 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | | Inflammation, Chronic | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +| Diverticulum | | Erosion | 1 | Inflammation, Focal | | Ulcer | 2 | Epithelium, Hyperplasia, Focal | | Epithelium, Hyperplasia | 3 2 | Serosa, Foreign Body | 1 | Serosa, Inflammation, Chronic, Focal | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +| Epithelium, Necrosis, Focal | | |__________________________________________________________________________| Tongue | | Epithelium, Hyperplasia, Focal | | |__________________________________________________________________________| Tooth | + | Peridontal Tissue, Inflammation, | | Chronic | | __________________________________________|__________________________________________________________________________| Page 103 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3| | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3000 PPM | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Focal | | Cardiomyopathy | 1 2 | Fibrosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 1 2 | Cytoplasmic Alteration, Focal | 1 | Vacuolization Cytoplasmic, Focal | 1 1 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 2 1 | Hyperplasia | 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Hyperplasia | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | 1 2 | Pars Distalis, Cytoplasmic | | Alteration, Focal | 1 1 1 | Pars Distalis, Degeneration, Cystic, | | Focal | | Pars Distalis, Hyperplasia, Focal | 2 | Pars Intermedia, Cyst | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 2 2 2 2 2 2 1 2 3 2 2| Follicle, Cyst | X | __________________________________________|__________________________________________________________________________| Page 104 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3| | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3000 PPM | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Follicle, Mineralization, Focal | 3 3 3 3 3 3 3 3 3 2 3 3 3 2 2 3 2 2 3 3 3 3 3 3 3| Follicular Cell, Hyperplasia, Cystic,| | Focal | 2 | Follicular Cell, Hyperplasia | 1 1 2 2 2 3 2 2 3 2 2 1 1 2 2 1 1 3 2 1 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Mediastinum, Hemorrhage | | Thoracic, Hemorrhage | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Granuloma Sperm | 2 | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 | Hyperplasia, Cystic | 4 | Inflammation, Chronic | 2 3 2 3 2 | Inflammation, Suppurative | 4 | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 3 1 1 1 3 1| Epithelium, Hyperplasia, Focal | 1 1 | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 4 3 3 3 3 3 3 | Bilateral, Interstitial Cell, | | Hyperplasia, Focal | 1 | Germinal Epithelium, Atrophy | | Interstitial Cell, Hyperplasia, Focal| 1 1 2 1 | Interstitial Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | __________________________________________|__________________________________________________________________________| Page 105 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3| | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3000 PPM | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | 3 3 3 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Mediastinal, Ectasia | | Mediastinal, Hemorrhage | 3 | Mediastinal, Hyperplasia, Histiocytic| 2 3 3 | Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Pigmentation | 3 | Pancreatic, Angiectasis | 3 | Pancreatic, Ectasia | 3 | Pancreatic, Hemorrhage | 3 | Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 3 3 3 2 3 3| Pancreatic, Hyperplasia, Lymphoid | 2 | Pancreatic, Pigmentation | | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 | Hemorrhage | | Hyperplasia, Histiocytic | 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Fibrosis, Focal | | Hematopoietic Cell Proliferation | 3 3 2 | Hemorrhage, Focal | | Inflammation, Granulomatous | 2 | Necrosis, Focal | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 106 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3| | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3000 PPM | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Mammary Gland | + M + + + M + + + + + M + + + + + + + + + + + + +| Dilatation | 2 3 | Hyperplasia, Cystic | 3 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | 3| Hemorrhage, Focal | | Inflammation, Chronic, Focal | | Necrosis, Focal | | Subcutaneous Tissue, Angiectasis, | | Focal | 2 | Subcutaneous Tissue, Cyst | 2 | Subcutaneous Tissue, Foreign Body | 3 | Subcutaneous Tissue, Hemorrhage, | | Focal | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Fibrosis, Focal | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression, Focal | 2 | Hemorrhage, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | | Glands, Hyperplasia, Focal | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage, Focal | 2 | Hyperplasia, Histiocytic | 1 | __________________________________________|__________________________________________________________________________| Page 107 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3| | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3000 PPM | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Infiltration Cellular, Focal, Mixed | | Cell | | Inflammation, Focal | | Metaplasia, Focal, Osseous | 1 1 | Metaplasia, Osseous | 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 1 2 2| Alveolus, Foreign Body, Focal | | Interstitium, Edema | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Histiocytic | 1 | Hyperplasia, Focal | | Inflammation, Chronic, Focal | 3 | Inflammation, Focal, Granulomatous | 1 | Epithelium, Hyperplasia, Focal | 3 | |__________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | 2 | Cyst | 3 1 | Fibrosis, Focal | 2 | Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1| Renal Tubule, Accumulation, Hyaline | | Droplet | 3 | Renal Tubule, Pigmentation | 3 | __________________________________________|__________________________________________________________________________| Page 108 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 8| 3| 3| 3| 3| 3| 3| 2| 2| 2| 8| 2| 2| 8| 9| 6| 0| 2| 2| 3| 3| 3| 3| | 6| 1| 7| 0| 0| 0| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 2| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3000 PPM | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| | 1| 2| 3| 4| 5| 6| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 109 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2| | | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 3000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L | | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + M + A + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + M + A + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X | 2 | Cholangiofibrosis | | 1 2.0| Congestion | | 1 3.0| Degeneration, Cystic, Focal | 1 2| 7 1.7| Eosinophilic Focus | | 1 | Hematopoietic Cell Proliferation | 1 | 2 1.0| Hepatodiaphragmatic Nodule | X X X X X | 9 | Hyperplasia, Focal, Lymphoid | | 1 3.0| Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 | 36 1.9| Inflammation, Granulomatous | 1 1 2 1 2 | 11 1.4| Mixed Cell Focus | X X X X X X X X X X X X X X X | 26 | Necrosis, Focal | 2 | 1 2.0| Bile Duct, Cyst | X | 1 | Bile Duct, Hyperplasia | 3 3 2 3 3 3 3 1 2 2 3 2 3 2 3 3 3 1 3 3 3 3 3 4| 49 2.8| Hepatocyte, Necrosis, Focal | 1 | 2 1.5| Hepatocyte, Vacuolization | | | Cytoplasmic, Diffuse | 2 | 1 2.0| Hepatocyte, Vacuolization | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 110 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2| | | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 3000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L | | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Cytoplasmic, Focal | 2 2 2 2 1 1 2 2 2 1 2 1 | 23 1.6| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 2 | 3 2.3| Oval Cell, Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Mesentery | + + + + + + + +| 20 | Fibrosis, Focal | | 1 3.0| Hemorrhage | 4 | 2 3.5| Necrosis, Focal | | 1 3.0| Artery, Inflammation, Chronic | | 1 3.0| Fat, Necrosis, Focal | 3 3 3 3 2 2| 10 2.7| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Focal | | 1 2.0| Fibrosis, Focal | 3 | 1 3.0| Acinus, Atrophy, Diffuse | 3 | 1 3.0| Acinus, Atrophy, Focal | 3 3 1 2 1 2 2 2 3 2 3 1 2 3 3 3 2| 36 2.0| Duct, Cyst, Focal, Multiple | 2 2 2 1 3 1 | 12 1.9| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Focal | 1 | 1 1.0| Inflammation, Chronic | 2 | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Diverticulum | 2 | 1 2.0| Erosion | | 1 1.0| Inflammation, Focal | 2 | 1 2.0| Ulcer | 2 2 2 | 4 2.0| Epithelium, Hyperplasia, Focal | 2 | 1 2.0| Epithelium, Hyperplasia | 2 2 2 1 | 6 2.0| Serosa, Foreign Body | | 1 1.0| Serosa, Inflammation, Chronic, Focal | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 111 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2| | | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 3000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L | | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Epithelium, Necrosis, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Tongue | + | 1 | Epithelium, Hyperplasia, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Tooth | + | 2 | Peridontal Tissue, Inflammation, | | | Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + | 9 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Focal | 2 | 1 2.0| Cardiomyopathy | 2 2 3 | 5 2.0| Fibrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 1 | 5 1.6| Cytoplasmic Alteration, Focal | 2 1 | 3 1.3| Vacuolization Cytoplasmic, Focal | 2 2 2 2 1 1 | 10 1.4| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 2 1 | 7 1.4| Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 112 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2| | | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 3000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L | | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | | 1 2.0| Pars Distalis, Cyst | 3 | 3 2.0| Pars Distalis, Cytoplasmic | | | Alteration, Focal | 1 1 | 5 1.0| Pars Distalis, Degeneration, Cystic, | | | Focal | 1 | 1 1.0| Pars Distalis, Hyperplasia, Focal | 1 | 2 1.5| Pars Intermedia, Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 2 2 1 2 2 2 1 2 2 1 1 2 2 2 1 2 2 1 2| 34 1.7| Follicle, Cyst | | 1 | Follicle, Mineralization, Focal | 3 3 3 3 3 3 3 1 1 1 3 1 3 1 2 3 3 3 3 3 3 3 3 3| 49 2.7| Follicular Cell, Hyperplasia, Cystic,| | | Focal | | 1 2.0| Follicular Cell, Hyperplasia | 1 1 1 2 2 1 3 2 2 3 1 2 3 2 2 2 2 1 2 1 | 43 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + + +| 4 | Mediastinum, Hemorrhage | 3 | 1 3.0| Thoracic, Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| Granuloma Sperm | | 1 2.0| |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 3 | 2 2.5| Hyperplasia, Cystic | | 1 4.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 113 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2| | | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 3000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L | | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Inflammation, Chronic | 2 1 1 3 1 2 | 11 2.0| Inflammation, Suppurative | 3 | 2 3.5| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 2 2 1 1 1 2 1 3 1 2 | 19 1.5| Epithelium, Hyperplasia, Focal | 1 2 1 | 5 1.2| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 3 3 4 | 13 3.2| Bilateral, Interstitial Cell, | | | Hyperplasia, Focal | 2 | 2 1.5| Germinal Epithelium, Atrophy | 3 | 1 3.0| Interstitial Cell, Hyperplasia, Focal| 1 2 2 2 2 | 9 1.6| Interstitial Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | 3 3 | 5 3.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + +| 38 | Hemorrhage | 2 | 1 2.0| Mediastinal, Ectasia | 3 | 1 3.0| Mediastinal, Hemorrhage | | 1 3.0| Mediastinal, Hyperplasia, Histiocytic| 3 | 4 2.8| Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0| Mediastinal, Pigmentation | | 1 3.0| Pancreatic, Angiectasis | | 1 3.0| Pancreatic, Ectasia | 3 | 2 3.0| Pancreatic, Hemorrhage | 2 3 3 | 4 2.8| Pancreatic, Hyperplasia, Histiocytic | 3 3 3 2 3 3 3 3 | 19 2.9| Pancreatic, Hyperplasia, Lymphoid | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 114 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2| | | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 3000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L | | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Pancreatic, Pigmentation | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M + M M M + M M| 2 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 2 3.0| Hemorrhage | 3 | 1 3.0| Hyperplasia, Histiocytic | 3 2 3 | 4 2.8| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Fibrosis, Focal | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 3 2 | 6 2.5| Hemorrhage, Focal | 3 | 1 3.0| Inflammation, Granulomatous | 1 2 | 3 1.7| Necrosis, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Hemorrhage | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + M + + + + + + + + + + + + M + + M M I + + + + +| 42 | Dilatation | | 2 2.5| Hyperplasia, Cystic | | 1 3.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 3.0| Hemorrhage, Focal | 2 | 1 2.0| Inflammation, Chronic, Focal | 2 | 1 2.0| Necrosis, Focal | 2 | 1 2.0| Subcutaneous Tissue, Angiectasis, | | | Focal | | 1 2.0| Subcutaneous Tissue, Cyst | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 115 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2| | | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 3000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L | | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Subcutaneous Tissue, Foreign Body | | 1 3.0| Subcutaneous Tissue, Hemorrhage, | | | Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + | 4 | Fibrosis, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression, Focal | | 1 2.0| Hemorrhage, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + | 1 | Glands, Hyperplasia, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 1 2.0| Hemorrhage, Focal | | 1 2.0| Hyperplasia, Histiocytic | 1 | 2 1.0| Infiltration Cellular, Focal, Mixed | | | Cell | 3 | 1 3.0| Inflammation, Focal | 3 | 1 3.0| Metaplasia, Focal, Osseous | | 2 1.0| Metaplasia, Osseous | | 2 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 2 2 | 5 1.8| Alveolus, Foreign Body, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 116 NTP Experiment-Test: 92012-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 03/14/03 Route: DOSED FEED Time: 10:39:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 3| 4| 2| 6| 7| 5| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 9| 9| 4| 0| 3| 9| 3| 8| 2| 2| 1| 7| 2| 2| 2| 2| 2| 2| | | 0| 0| 0| 0| 0| 0| 0| 5| 1| 9| 5| 1| 8| 1| 9| 9| 9| 8| 4| 9| 9| 9| 9| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 3000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L | | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Interstitium, Edema | 2 | 1 2.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nasolacrimal Duct, Inflammation | 3 3 | 2 3.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal, Histiocytic | | 1 1.0| Hyperplasia, Focal | 1 1 | 2 1.0| Inflammation, Chronic, Focal | 1 1 | 3 1.7| Inflammation, Focal, Granulomatous | | 1 1.0| Epithelium, Hyperplasia, Focal | | 1 3.0| |__________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Focal | | 1 2.0| Cyst | | 2 2.0| Fibrosis, Focal | | 1 2.0| Nephropathy | 1 1 1 1 1 1 2 2 1 2 2 1 1 1 3 1 1 3 1 1 1 1 1 1| 46 1.2| Renal Tubule, Accumulation, Hyaline | | | Droplet | 3 | 2 3.0| Renal Tubule, Pigmentation | 2 2 | 3 2.3| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 117 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------