TDMS Study 92012-06 Pathology Tables
NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:41:02 27 WEEK SSAC/FINAL#1 MICE Facility: Southern Research Institute Chemical CAS #: 693-98-1 Lock Date: 10/16/01 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:41:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0PPM 625 PPM 1250 PPM 2500 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 60 60 Scheduled Sacrifice 10 10 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 (10%) Infiltration Cellular, Mixed Cell 6 (60%) 7 (70%) 3 (30%) 5 (50%) Necrosis, Focal 1 (10%) Hepatocyte, Vacuolization Cytoplasmic 1 (10%) 2 (20%) 4 (40%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Accessory Adrenal Cortical Nodule 2 (20%) 1 (10%) Thyroid Gland (8) (10) (10) (10) Follicular Cell, Hypertrophy 8 (80%) 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (10) (10) (10) Cyst 1 (10%) 1 (10%) Uterus (10) (10) (10) (10) Hyperplasia, Cystic 3 (30%) 1 (10%) 4 (40%) 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:41:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0PPM 625 PPM 1250 PPM 2500 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (10) (10) (10) (10) Pigmentation 2 (20%) 1 (10%) 2 (20%) Spleen (10) (10) (10) (10) Hematopoietic Cell Proliferation 2 (20%) 5 (50%) 6 (60%) 10 (100%) Pigmentation 1 (10%) 3 (30%) 7 (70%) 10 (100%) Lymphoid Follicle, Atrophy 4 (40%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (10) (10) (10) (10) Inflammation, Chronic 1 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Hyperplasia, Lymphoid 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Nephropathy 1 (10%) 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:41:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0PPM 625 PPM 1250 PPM 2500 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 60 60 Scheduled Sacrifice 10 10 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 (10%) Infiltration Cellular, Mixed Cell 2 (20%) 3 (30%) 6 (60%) 2 (20%) Necrosis, Focal 1 (10%) Hepatocyte, Karyomegaly 5 (50%) Hepatocyte, Vacuolization Cytoplasmic 4 (40%) Mesentery (1) Fat, Necrosis 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) (10) Valve, Hypertrophy 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Accessory Adrenal Cortical Nodule 2 (20%) 1 (10%) Hyperplasia, Focal 1 (10%) Hypertrophy, Focal 1 (10%) Thyroid Gland (10) (10) (10) (10) Follicle, Cyst 1 (10%) Follicular Cell, Hypertrophy 5 (50%) 9 (90%) 10 (100%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:41:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0PPM 625 PPM 1250 PPM 2500 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) (10) (10) Cyst 1 (10%) Inflammation, Chronic 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (10) (10) (10) (10) Hyperplasia 1 (10%) 2 (20%) 5 (50%) Spleen (10) (10) (10) (10) Hematopoietic Cell Proliferation 5 (50%) 10 (100%) 10 (100%) Pigmentation 1 (10%) 10 (100%) 10 (100%) Lymphoid Follicle, Atrophy 5 (50%) 10 (100%) Lymphoid Follicle, Hyperplasia 1 (10%) Thymus (10) (10) (10) (10) Atrophy 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Hemorrhage 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03 Route: DOSED FEED Time: 14:41:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0PPM 625 PPM 1250 PPM 2500 PPM ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Cyst 1 (10%) Hydronephrosis 1 (10%) 1 (10%) Nephropathy 1 (10%) 1 (10%) 2 (20%) Renal Tubule, Pigmentation 1 (10%) 10 (100%) Urinary Bladder (10) (10) (10) (10) Transitional Epithelium, Hyperplasia 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 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