TDMS Study 92012-06 Pathology Tables
NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:41:02
27 WEEK SSAC/FINAL#1 MICE
Facility: Southern Research Institute
Chemical CAS #: 693-98-1
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:41:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 625 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Infiltration Cellular, Mixed Cell 6 (60%) 7 (70%) 3 (30%) 5 (50%)
Necrosis, Focal 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 1 (10%) 2 (20%) 4 (40%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 2 (20%) 1 (10%)
Thyroid Gland (8) (10) (10) (10)
Follicular Cell, Hypertrophy 8 (80%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Cyst 1 (10%) 1 (10%)
Uterus (10) (10) (10) (10)
Hyperplasia, Cystic 3 (30%) 1 (10%) 4 (40%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:41:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 625 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Pigmentation 2 (20%) 1 (10%) 2 (20%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (20%) 5 (50%) 6 (60%) 10 (100%)
Pigmentation 1 (10%) 3 (30%) 7 (70%) 10 (100%)
Lymphoid Follicle, Atrophy 4 (40%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Inflammation, Chronic 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Nephropathy 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:41:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 625 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Infiltration Cellular, Mixed Cell 2 (20%) 3 (30%) 6 (60%) 2 (20%)
Necrosis, Focal 1 (10%)
Hepatocyte, Karyomegaly 5 (50%)
Hepatocyte, Vacuolization Cytoplasmic 4 (40%)
Mesentery (1)
Fat, Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10)
Valve, Hypertrophy 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 2 (20%) 1 (10%)
Hyperplasia, Focal 1 (10%)
Hypertrophy, Focal 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Follicle, Cyst 1 (10%)
Follicular Cell, Hypertrophy 5 (50%) 9 (90%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:41:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 625 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10) (10) (10)
Cyst 1 (10%)
Inflammation, Chronic 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10)
Hyperplasia 1 (10%) 2 (20%) 5 (50%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 5 (50%) 10 (100%) 10 (100%)
Pigmentation 1 (10%) 10 (100%) 10 (100%)
Lymphoid Follicle, Atrophy 5 (50%) 10 (100%)
Lymphoid Follicle, Hyperplasia 1 (10%)
Thymus (10) (10) (10) (10)
Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 92012-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-METHYLIMIDAZOLE Date: 02/24/03
Route: DOSED FEED Time: 14:41:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 625 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Cyst 1 (10%)
Hydronephrosis 1 (10%) 1 (10%)
Nephropathy 1 (10%) 1 (10%) 2 (20%)
Renal Tubule, Pigmentation 1 (10%) 10 (100%)
Urinary Bladder (10) (10) (10) (10)
Transitional Epithelium, Hyperplasia 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
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