TDMS Study 92012-06 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39 LAB: Southern Research Inst 2-METHYLIMIDAZOLE DATE: 02/24/03 EXPERIMENT: 92012 TEST: 06 TIME: 14:00:58 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C92012B ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39 LAB: SOUTHERN RESEARCH INSTITUTE 2-METHYLIMIDAZOLE DATE: 02/24/03 EXPERIMENT: 92012 TEST: 06 TIME: 14:21:33 TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: 92012B CONT: N01-ES-85420 CAS: 693-98-1 FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE ================================================================================================================================== 0PPM 625 PPM 1250 PPM 2500 PPM ---------------- --------------------------------- --------------------------------- --------------------------------- DOSE/ DOSE/ DOSE/ GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) ================================================================================================================================== 4 4.5 23.1 4.8 23.0 1.07 129 4.7 23.0 1.04 255 4.8 23.2 1.07 515 8 3.9 26.6 4.1 26.1 1.05 98 3.8 24.9 0.97 192 4.0 25.2 1.03 400 12 4.2 31.4 4.6 30.2 1.10 96 4.4 29.7 1.05 184 4.4 29.0 1.05 376 16 4.4 33.4 4.3 32.9 0.98 81 4.3 32.0 0.98 168 4.2 31.2 0.95 338 20 4.5 35.9 4.7 34.4 1.04 85 4.5 33.3 1.00 168 4.3 32.9 0.96 325 24 4.4 38.0 4.5 36.7 1.02 77 4.5 35.1 1.02 159 4.5 34.1 1.02 328 28 4.4 40.2 4.3 39.1 0.98 69 4.5 37.9 1.02 150 4.4 37.2 1.00 298 32 4.7 41.9 4.6 40.7 0.98 71 4.5 39.7 0.96 143 4.6 38.3 0.98 297 36 4.3 43.5 4.6 42.4 1.07 68 4.8 41.4 1.12 145 4.6 40.0 1.07 288 40 4.3 44.5 4.4 43.7 1.02 63 4.4 42.6 1.02 129 4.5 40.8 1.05 273 44 4.8 44.5 4.8 43.4 1.00 69 4.7 42.4 0.98 139 4.8 40.4 1.00 297 48 4.8 44.7 4.6 44.2 0.96 66 4.6 43.0 0.96 134 4.8 40.7 1.00 294 52 4.8 44.8 4.8 44.8 1.00 67 4.7 43.8 0.98 135 4.6 41.1 0.96 281 56 5.3 45.5 5.3 44.3 1.00 74 5.2 43.8 0.98 148 5.0 40.8 0.94 308 60 5.0 45.2 4.9 44.5 0.98 69 4.9 43.8 0.98 141 4.9 39.9 0.98 310 64 5.1 45.9 5.1 45.0 1.00 71 5.0 43.7 0.98 145 4.9 40.1 0.96 306 68 5.2 46.2 5.1 45.4 0.98 70 5.2 44.4 1.00 146 5.1 40.9 0.98 312 72 5.1 46.8 4.9 46.1 0.96 67 5.0 44.9 0.98 139 4.8 41.3 0.94 290 76 4.8 46.4 4.8 45.6 1.00 66 4.7 44.0 0.98 134 4.6 41.0 0.96 279 80 4.3 46.6 4.3 45.5 1.00 59 4.4 43.8 1.02 124 4.1 41.0 0.95 251 84 5.0 45.7 5.1 45.0 1.02 71 5.3 43.1 1.06 152 4.7 40.1 0.94 295 88 4.7 45.7 4.6 45.5 0.98 64 4.7 42.9 1.00 138 4.6 40.3 0.98 285 92 4.7 44.9 5.0 45.1 1.06 69 5.0 42.2 1.06 149 4.6 40.1 0.98 285 96 5.3 44.7 5.2 44.6 0.98 73 5.3 42.9 1.00 153 5.2 39.1 0.98 334 100 5.3 45.2 5.0 44.0 0.94 72 5.1 42.2 0.96 152 4.9 39.2 0.92 312 104 4.9 42.5 5.1 42.2 1.04 76 4.8 40.8 0.98 148 4.8 37.3 0.98 322 1 TO 13 WEEKS ---------------- MEAN 4.2 27.0 4.5 26.4 1.07 108 4.3 25.9 1.02 210 4.4 25.8 1.05 431 SD(D) 0.3 0.4 0.02 19 0.4 0.04 39 0.4 0.02 74 CV(E) 6.7 7.9 2.1 17.5 10.3 4.1 18.4 8.4 2.0 17.3 14 TO 52 WEEKS ---------------- MEAN 4.5 41.1 4.6 40.2 1.01 72 4.6 39.1 1.00 147 4.5 37.7 1.00 302 SD(D) 0.2 0.2 0.03 7 0.2 0.05 14 0.2 0.04 21 CV(E) 4.6 4.2 3.5 9.9 3.3 4.7 9.5 4.3 3.9 7.1 > 52 WEEKS ---------------- MEAN 5.0 45.5 5.0 44.8 1.00 69 5.0 43.3 1.00 144 4.8 40.1 0.96 299 SD(D) 0.3 0.3 0.03 4 0.3 0.03 8 0.3 0.02 22 CV(E) 5.9 5.1 3.2 6.4 5.2 3.2 5.8 6.0 2.1 7.2 ================================================================================================================================== (A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY. (B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS. (C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT. (D) STANDARD DEVIATION OF WEEKLY MEAN. (E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100. FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE ================================================================================================================================== 0PPM 625 PPM 1250 PPM 2500 PPM ---------------- --------------------------------- --------------------------------- --------------------------------- DOSE/ DOSE/ DOSE/ GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) ================================================================================================================================== 4 2.7 20.3 3.3 20.1 1.22 102 2.9 20.0 1.07 180 2.9 20.2 1.07 364 8 3.6 23.1 3.7 23.6 1.03 98 3.4 23.2 0.94 182 3.6 22.9 1.00 389 12 3.4 25.0 3.5 24.5 1.03 89 3.5 24.2 1.03 181 3.5 24.1 1.03 365 16 3.3 25.8 3.3 25.9 1.00 81 3.5 25.4 1.06 170 3.4 24.7 1.03 345 20 3.1 27.7 3.4 27.6 1.10 77 3.2 26.8 1.03 151 3.3 26.7 1.06 308 24 3.6 28.7 3.4 29.2 0.94 74 3.6 28.6 1.00 159 3.7 27.9 1.03 336 28 3.7 30.5 4.1 31.6 1.11 81 3.9 30.7 1.05 157 4.0 29.7 1.08 333 32 3.6 31.0 3.7 31.9 1.03 72 3.6 31.4 1.00 143 3.6 29.6 1.00 306 36 3.8 30.3 3.7 32.3 0.97 73 4.0 32.0 1.05 157 3.7 29.8 0.97 314 40 3.8 32.9 4.0 34.0 1.05 73 3.8 34.6 1.00 136 3.8 32.1 1.00 298 44 4.0 32.6 4.5 33.4 1.13 84 4.3 33.5 1.08 159 4.4 31.2 1.10 352 48 3.6 32.4 3.7 33.4 1.03 70 3.8 33.7 1.06 141 3.9 31.7 1.08 308 52 4.0 32.5 3.9 34.7 0.98 70 3.8 34.6 0.95 137 3.5 32.2 0.88 275 56 4.3 33.6 4.5 34.5 1.05 82 4.5 34.1 1.05 164 4.4 31.5 1.02 350 60 4.1 34.2 4.2 35.1 1.02 75 4.2 34.5 1.02 151 4.0 31.1 0.98 321 64 4.0 34.3 4.0 35.3 1.00 71 4.0 34.7 1.00 144 3.9 32.0 0.98 306 68 4.5 34.8 4.6 35.5 1.02 81 4.6 35.2 1.02 164 4.4 32.5 0.98 339 72 4.2 35.0 4.3 36.9 1.02 72 4.4 35.4 1.05 157 4.8 31.8 1.14 373 76 3.2 34.7 3.4 35.7 1.06 59 3.3 35.3 1.03 117 3.2 31.3 1.00 257 80 4.1 37.0 4.1 37.5 1.00 69 4.0 36.6 0.98 135 4.0 33.0 0.98 300 84 4.4 38.8 4.8 36.5 1.09 82 4.9 38.1 1.11 159 4.6 34.3 1.05 338 88 4.2 38.5 4.2 38.4 1.00 68 4.3 38.7 1.02 137 4.1 33.8 0.98 302 92 3.8 38.2 3.8 38.0 1.00 63 3.9 37.9 1.03 128 3.8 33.5 1.00 281 96 4.3 38.2 4.4 38.2 1.02 72 4.2 38.0 0.98 138 4.1 34.4 0.95 297 100 4.8 38.2 4.2 38.8 0.88 68 4.2 38.6 0.88 137 4.1 34.1 0.85 303 104 4.5 37.8 5.1 38.2 1.13 84 4.6 38.0 1.02 153 4.5 33.6 1.00 336 1 TO 13 WEEKS ---------------- MEAN 3.3 22.8 3.5 22.8 1.09 96 3.3 22.5 1.02 181 3.3 22.4 1.03 373 SD(D) 0.5 0.2 0.11 7 0.3 0.07 1 0.3 0.04 14 CV(E) 14.2 5.6 10.2 6.8 10.0 6.5 0.7 10.3 3.6 3.8 14 TO 52 WEEKS ---------------- MEAN 3.6 30.5 3.8 31.4 1.03 75 3.7 31.1 1.03 151 3.7 29.6 1.02 317 SD(D) 0.3 0.3 0.06 5 0.3 0.04 11 0.3 0.07 24 CV(E) 7.8 9.2 6.0 6.5 7.7 3.8 7.5 8.3 6.5 7.5 > 52 WEEKS ---------------- MEAN 4.2 36.4 4.3 36.8 1.02 73 4.2 36.5 1.01 145 4.1 32.8 0.99 316 SD(D) 0.4 0.4 0.06 8 0.4 0.05 14 0.4 0.06 31 CV(E) 9.4 10.3 5.8 10.7 9.5 5.3 10.0 9.8 6.4 9.9 ================================================================================================================================== (A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY. (B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS. (C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT. (D) STANDARD DEVIATION OF WEEKLY MEAN. (E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100. DIAGNOSTIC TRAILER REPORT FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE ========================================================================================================= 0PPM 625 PPM 1250 PPM 2500 PPM ---------------------- ---------------------- ---------------------- ---------------------- DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS ========================================================================================================== B 21.0 60 21.0 60 21.1 60 20.8 60 1 21.0 60 21.0 60 21.1 60 20.8 60 3 5.2 876 4 4.5 9123 23.1 59 4.8 9870 23.0 60 4.7 8970 23.0 53 4.8 9131 23.2 56 8 3.9 9840 26.6 59 4.1 9758 26.1 59 3.8 9012 24.9 55 4.0 9124 25.2 56 12 4.2 10020 31.4 59 4.6 10017 30.2 59 4.4 9320 29.7 55 4.4 9390 29.0 56 16 4.4 9950 33.4 59 4.3 9823 32.9 59 4.3 9137 32.0 55 4.2 9126 31.2 56 20 4.5 9668 35.9 59 4.7 9813 34.4 59 4.5 9044 33.3 55 4.3 9187 32.9 56 24 4.4 9956 38.0 59 4.5 9824 36.7 59 4.5 8800 35.1 55 4.5 9184 34.1 56 28 4.4 8189 40.2 49 4.3 8167 39.1 49 4.5 7228 37.9 45 4.4 7536 37.2 46 32 4.7 8229 41.9 49 4.6 8180 40.7 49 4.5 7497 39.7 45 4.6 7471 38.3 46 36 4.3 8217 43.5 49 4.6 8186 42.4 49 4.8 6973 41.4 45 4.6 7596 40.0 46 40 4.3 8085 44.5 49 4.4 8032 43.7 49 4.4 7345 42.6 45 4.5 7484 40.8 46 44 4.8 8096 44.5 49 4.8 8062 43.4 49 4.7 7312 42.4 45 4.8 7447 40.4 46 48 4.8 8184 44.7 49 4.6 8183 44.2 49 4.6 7478 43.0 45 4.8 7548 40.7 46 52 4.8 8231 44.8 49 4.8 8219 44.8 49 4.7 7352 43.8 45 4.6 7671 41.1 46 56 5.3 8126 45.5 49 5.3 8094 44.3 49 5.2 7382 43.8 45 5.0 7474 40.8 46 60 5.0 8254 45.2 49 4.9 8241 44.5 49 4.9 7295 43.8 44 4.9 7442 39.9 46 64 5.1 8286 45.9 49 5.1 8218 45.0 49 5.0 7349 43.7 44 4.9 7568 40.1 46 68 5.2 8063 46.2 49 5.1 8023 45.4 49 5.2 7184 44.4 44 5.1 7488 40.9 46 72 5.1 8084 46.8 49 4.9 8030 46.1 49 5.0 7153 44.9 44 4.8 7457 41.3 46 76 4.8 8111 46.4 49 4.8 8050 45.6 49 4.7 6859 44.0 43 4.6 7332 41.0 46 80 4.3 8012 46.6 49 4.3 8212 45.5 49 4.4 6953 43.8 42 4.1 7418 41.0 45 84 5.0 8188 45.7 49 5.1 8072 45.0 49 5.3 6896 43.1 42 4.7 7365 40.1 45 88 4.7 8151 45.7 49 4.6 8261 45.5 49 4.7 6904 42.9 42 4.6 7541 40.3 45 92 4.7 8118 44.9 48 5.0 8271 45.1 49 5.0 6575 42.2 40 4.6 7571 40.1 45 96 5.3 7266 44.7 46 5.2 7902 44.6 48 5.3 6225 42.9 38 5.2 6881 39.1 43 100 5.3 6966 45.2 44 5.0 7772 44.0 48 5.1 6302 42.2 38 4.9 6706 39.2 42 104 4.9 7232 42.5 43 5.1 7580 42.2 47 4.8 5927 40.8 36 4.8 6556 37.3 40 MEAN BODY WGT FOR WEEKS 1 TO 13 25.5 25.1 24.7 24.6 14 TO 52 41.1 40.2 39.1 37.7 > 52 45.5 44.8 43.3 40.1 ========================================================================================================= (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT. DIAGNOSTIC TRAILER REPORT FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE CHRONIC DOSED FEED STUDY OF 2-METHYLIMIDAZOLE ========================================================================================================= 0PPM 625 PPM 1250 PPM 2500 PPM ---------------------- ---------------------- ---------------------- ---------------------- DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS ========================================================================================================== B 17.4 60 17.3 60 17.3 60 17.7 60 1 17.4 60 17.3 60 17.3 60 17.7 60 3 3.8 4392 4.3 4354 4.3 4212 4.1 4174 4 2.7 5743 20.3 60 3.3 5569 20.1 59 2.9 5330 20.0 59 2.9 5808 20.2 60 7 3.0 5885 3.0 5674 2.8 5654 3.1 5706 8 3.6 4002 23.1 60 3.7 3924 23.6 59 3.4 3912 23.2 59 3.6 3976 22.9 60 12 3.4 10153 25.0 60 3.5 10013 24.5 59 3.5 9980 24.2 59 3.5 10115 24.1 60 16 3.3 10044 25.8 60 3.3 9750 25.9 59 3.5 9724 25.4 59 3.4 9857 24.7 60 20 3.1 9893 27.7 60 3.4 9683 27.6 59 3.2 9421 26.8 58 3.3 9710 26.7 60 24 3.6 10023 28.7 60 3.4 9744 29.2 59 3.6 9538 28.6 58 3.7 9736 27.9 60 28 3.7 8259 30.5 50 4.1 8057 31.6 49 3.9 7697 30.7 48 4.0 8077 29.7 49 32 3.6 8527 31.0 50 3.7 8296 31.9 49 3.6 8101 31.4 48 3.6 8425 29.6 50 36 3.8 8563 30.3 50 3.7 8275 32.3 49 4.0 8021 32.0 48 3.7 8355 29.8 50 40 3.8 8260 32.9 50 4.0 7979 34.0 49 3.8 7783 34.6 48 3.8 8082 32.1 50 44 4.0 8249 32.6 50 4.5 8047 33.4 49 4.3 7779 33.5 48 4.4 8075 31.2 50 48 3.6 8280 32.4 50 3.7 8086 33.4 49 3.8 7912 33.7 48 3.9 8120 31.7 50 52 4.0 8546 32.5 50 3.9 8354 34.7 49 3.8 8173 34.6 48 3.5 8496 32.2 50 56 4.3 8332 33.6 50 4.5 8074 34.5 49 4.5 7872 34.1 48 4.4 8107 31.5 50 60 4.1 8357 34.2 49 4.2 8181 35.1 48 4.2 8049 34.5 48 4.0 7888 31.1 50 64 4.0 8151 34.3 49 4.0 7959 35.3 48 4.0 7916 34.7 48 3.9 8097 32.0 50 68 4.5 7967 34.8 49 4.6 7790 35.5 48 4.6 7768 35.2 48 4.4 7712 32.5 50 72 4.2 8126 35.0 49 4.3 7941 36.9 48 4.4 7840 35.4 48 4.8 8153 31.8 50 76 3.2 7865 34.7 49 3.4 7810 35.7 48 3.3 7767 35.3 48 3.2 7914 31.3 49 80 4.1 7911 37.0 48 4.1 8098 37.5 48 4.0 7946 36.6 48 4.0 8143 33.0 49 84 4.4 8057 38.8 48 4.8 8049 36.5 48 4.9 7779 38.1 47 4.6 8060 34.3 49 88 4.2 8279 38.5 48 4.2 8040 38.4 47 4.3 8019 38.7 47 4.1 8166 33.8 48 92 3.8 8088 38.2 48 3.8 7643 38.0 46 3.9 7712 37.9 46 3.8 8040 33.5 48 96 4.3 7617 38.2 47 4.4 7270 38.2 45 4.2 7253 38.0 45 4.1 7551 34.4 47 100 4.8 6762 38.2 47 4.2 7449 38.8 44 4.2 7381 38.6 44 4.1 7696 34.1 47 104 4.5 7764 37.8 46 5.1 7041 38.2 43 4.6 7023 38.0 43 4.5 7485 33.6 46 MEAN BODY WGT FOR WEEKS 1 TO 13 21.5 21.4 21.2 21.2 14 TO 52 30.5 31.4 31.1 29.6 > 52 36.4 36.8 36.5 32.8 ========================================================================================================= (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.