TDMS Study 92012-06 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Southern Research Inst 2-METHYLIMIDAZOLE DATE: 02/24/03
EXPERIMENT: 92012 TEST: 06 TIME: 14:00:58
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C92012B
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: SOUTHERN RESEARCH INSTITUTE 2-METHYLIMIDAZOLE DATE: 02/24/03
EXPERIMENT: 92012 TEST: 06 TIME: 14:12:39
SPECIES: MICE, B6C3F1
TEST TYPE: TWO YEAR ROUTE: DOSED FEED NTP: 92012B
CONT: N01-ES-85420 CAS: 693-98-1
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
TWO YEAR DOSED FEED STUDY OF 2-METHYLIMIDAZOLE
==========================================================================================================
WEEK 0PPM 625 PPM 1250 PPM 2500 PPM
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 21.0 60 21.0 100.0 60 21.1 100.5 60 20.8 99.0 60
1 21.0 60 21.0 100.0 60 21.1 100.5 60 20.8 99.0 60
4 23.1 59 23.0 99.6 60 23.0 99.6 53* 23.2 100.4 56
8 26.6 59 26.1 98.1 59 24.9 93.6 55 25.2 94.7 56
12 31.4 59 30.2 96.2 59 29.7 94.6 55 29.0 92.4 56
16 33.4 59 32.9 98.5 59 32.0 95.8 55 31.2 93.4 56
20 35.9 59 34.4 95.8 59 33.3 92.8 55 32.9 91.6 56
24 38.0 59 36.7 96.6 59 35.1 92.4 55 34.1 89.7 56
28 40.2 49 (I) 39.1 97.3 49 (I) 37.9 94.3 45 (I) 37.2 92.5 46 (I)
32 41.9 49 40.7 97.1 49 39.7 94.7 45 38.3 91.4 46
36 43.5 49 42.4 97.5 49 41.4 95.2 45 40.0 92.0 46
40 44.5 49 43.7 98.2 49 42.6 95.7 45 40.8 91.7 46
44 44.5 49 43.4 97.5 49 42.4 95.3 45 40.4 90.8 46
48 44.7 49 44.2 98.9 49 43.0 96.2 45 40.7 91.1 46
52 44.8 49 44.8 100.0 49 43.8 97.8 45 41.1 91.7 46
56 45.5 49 44.3 97.4 49 43.8 96.3 45 40.8 89.7 46
60 45.2 49 44.5 98.5 49 43.8 96.9 44 39.9 88.3 46
64 45.9 49 45.0 98.0 49 43.7 95.2 44 40.1 87.4 46
68 46.2 49 45.4 98.3 49 44.4 96.1 44 40.9 88.5 46
72 46.8 49 46.1 98.5 49 44.9 95.9 44 41.3 88.2 46
76 46.4 49 45.6 98.3 49 44.0 94.8 43 41.0 88.4 46
80 46.6 49 45.5 97.6 49 43.8 94.0 42 41.0 88.0 45
84 45.7 49 45.0 98.5 49 43.1 94.3 42 40.1 87.7 45
88 45.7 49 45.5 99.6 49 42.9 93.9 42 40.3 88.2 45
92 44.9 48 45.1 100.4 49 42.2 94.0 40 40.1 89.3 45
96 44.7 46 44.6 99.8 48 42.9 96.0 38 39.1 87.5 43
100 45.2 44 44.0 97.3 48 42.2 93.4 38 39.2 86.7 42
104 42.5 43 42.2 99.3 47 40.8 96.0 36 37.3 87.8 40
TERM. SAC. 43 46 36 40
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
TWO YEAR DOSED FEED STUDY OF 2-METHYLIMIDAZOLE
==========================================================================================================
WEEK 0PPM 625 PPM 1250 PPM 2500 PPM
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 17.4 60 17.3 99.4 60 17.3 99.4 60 17.7 101.7 60
1 17.4 60 17.3 99.4 60 17.3 99.4 60 17.7 101.7 60
4 20.3 60 20.1 99.0 59 20.0 98.5 59 20.2 99.5 60
8 23.1 60 23.6 102.2 59 23.2 100.4 59 22.9 99.1 60
12 25.0 60 24.5 98.0 59 24.2 96.8 59 24.1 96.4 60
16 25.8 60 25.9 100.4 59 25.4 98.4 59 24.7 95.7 60
20 27.7 60 27.6 99.6 59 26.8 96.8 58 26.7 96.4 60
24 28.7 60 29.2 101.7 59 28.6 99.7 58 27.9 97.2 60
28 30.5 50 (I) 31.6 103.6 49 (I) 30.7 100.7 48 (I) 29.7 97.4 49*(I)
32 31.0 50 31.9 102.9 49 31.4 101.3 48 29.6 95.5 50
36 30.3 50 32.3 106.6 49 32.0 105.6 48 29.8 98.3 50
40 32.9 50 34.0 103.3 49 34.6 105.2 48 32.1 97.6 50
44 32.6 50 33.4 102.5 49 33.5 102.8 48 31.2 95.7 50
48 32.4 50 33.4 103.1 49 33.7 104.0 48 31.7 97.8 50
52 32.5 50 34.7 106.8 49 34.6 106.5 48 32.2 99.1 50
56 33.6 50 34.5 102.7 49 34.1 101.5 48 31.5 93.8 50
60 34.2 49 35.1 102.6 48 34.5 100.9 48 31.1 90.9 50
64 34.3 49 35.3 102.9 48 34.7 101.2 48 32.0 93.3 50
68 34.8 49 35.5 102.0 48 35.2 101.1 48 32.5 93.4 50
72 35.0 49 36.9 105.4 48 35.4 101.1 48 31.8 90.9 50
76 34.7 49 35.7 102.9 48 35.3 101.7 48 31.3 90.2 49
80 37.0 48 37.5 101.4 48 36.6 98.9 48 33.0 89.2 49
84 38.8 48 36.5 94.1 48 38.1 98.2 47 34.3 88.4 49
88 38.5 48 38.4 99.7 47 38.7 100.5 47 33.8 87.8 48
92 38.2 48 38.0 99.5 46 37.9 99.2 46 33.5 87.7 48
96 38.2 47 38.2 100.0 45 38.0 99.5 45 34.4 90.1 47
100 38.2 47 38.8 101.6 44 38.6 101.0 44 34.1 89.3 47
104 37.8 46 38.2 101.1 43 38.0 100.5 43 33.6 88.9 46
TERM. SAC. 46 43 43 45
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.